CN106580939A - Chlorhexidine gluconate disinfectant - Google Patents
Chlorhexidine gluconate disinfectant Download PDFInfo
- Publication number
- CN106580939A CN106580939A CN201611160969.0A CN201611160969A CN106580939A CN 106580939 A CN106580939 A CN 106580939A CN 201611160969 A CN201611160969 A CN 201611160969A CN 106580939 A CN106580939 A CN 106580939A
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- CN
- China
- Prior art keywords
- chlorhexidine gluconate
- final concentration
- disinfectant solution
- medical
- weighed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/20—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/204—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
- A61L2300/206—Biguanides, e.g. chlorohexidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Materials Engineering (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention discloses a chlorhexidine gluconate disinfectant. The chlorhexidine gluconate disinfectant is prepared from a chlorhexidine gluconate solution, propylene glycol and polyethylene glycol nonylphenyl ether, or a chlorhexidine gluconate solution, propylene glycol polyethylene glycol nonylphenyl ether and ethyl alcohol. The chlorhexidine gluconate disinfectant is high in stability, resistant to high temperature, wide in spectrum, long-acting, free of irritating smell, safe, free of toxins and free of human body allergies, can be widely applied to hospitals, hotels, the service industry, public places, homes and the like, and has good market prospects.
Description
Technical field
The invention belongs to medicine and hygiene fieldses, be related to chlorhexidine gluconate disinfectant solution and its be prepared from it is medical wet
A kind of towel, and in particular to chlorhexidine gluconate sterilized for pre-surgical skin disinfection and cleaning wound and guard against cross infection
Disinfectant solution and its medical wet tissue being prepared from.
Background technology
Chlorhexidine gluconate medicinal liquid is colourless aqueous solution, and odorlessness, bitter in the mouth are stable in properties, shelf-stable, bactericidal effect
It is good, stimulate low, anaphylactic reaction seldom occur.Meanwhile, chlorhexidine gluconate is disinfection preservative, and its bacteriostasis and sterilization effect is wide
And it is strong, it is stronger than the antibacterial action of negative bacterium to gram positive bacteria, it is better than quaternary cationic surfactant bactericidal effect,
It is also effective to funguses.In the presence of having serum, blood still effectively, it is nonirritant to organizing, it is mainly used in skin degerming.
Chlorhexidine gluconate disinfectant solution currently used in the market, single varieties, specific aim be not strong, disinfection effect
Fruit is limited, it is difficult to meets existing diversification composite disinfecting sterilization and requires.Meanwhile, prepare degree of accuracy and cannot be guaranteed, and product
In pathogenic bacteria and microorganism effectively cannot control.Very big potential safety hazard is brought to patient or end user.With society
Development, the raising of people's health care consciousness, the also more and more higher of the requirement to sterile products.
The content of the invention
In order to solve problems of the prior art, an object of the present invention is that a kind of glucose pickling of offer must
The chlorhexidine gluconate disinfectant solution of the present invention is named as art Aminoplasmal Hepa-10 by safe disinfectant solution.The disinfectant solution stability is high, high temperature resistant,
Wide spectrum, long-acting, non-stimulated nature and flavor, safety non-toxic, human body is without allergy.
The second object of the present invention is to provide a kind of medical wet tissue, gluconic acid of the medical wet tissue comprising the present invention
Hibitane disinfectant solution.
To achieve these goals, present invention employs following technical scheme：
The invention provides a kind of chlorhexidine gluconate disinfectant solution, the chlorhexidine gluconate disinfectant solution includes following
Component：Final concentration of 2% chlorhexidine gluconate solution, final concentration of 9.9% Propylene Glycol, final concentration of 0.495%
Polyethylene glycol nonylphenyl ether, final concentration of 30% ethanol.
The invention provides a kind of chlorhexidine gluconate disinfectant solution, the chlorhexidine gluconate disinfectant solution includes group
Point：Final concentration of 4% chlorhexidine gluconate solution, final concentration of 9.9% Propylene Glycol, final concentration of 0.495% it is poly-
Ethylene glycol nonylplenyl ether.
Present invention also offers the preparation method of foregoing chlorhexidine gluconate disinfectant solution, the preparation method bag
Include following steps：
(1) 20% chlorhexidine gluconate is weighed, Agitation Tank, chlorhexidine gluconate final concentration of 2% is squeezed into；
(2) 99% Propylene Glycol is weighed, squeezes into Agitation Tank, Propylene Glycol final concentration of 9.9%；
(3) 99% polyethylene glycol nonylphenyl ether is weighed, squeezes into Agitation Tank, polyethylene glycol nonylphenyl ether is final concentration of
0.495%；
(4) 75% ethanol is weighed, squeezes into Agitation Tank, ethanol final concentration of 30%；
(5) pure water is weighed, squeezes into Agitation Tank；
(6) stir, obtain chlorhexidine gluconate disinfectant solution.
Or,
The preparation method comprises the steps：
(1) 20% chlorhexidine gluconate is weighed, Agitation Tank, chlorhexidine gluconate final concentration of 4% is squeezed into；
(2) 99% Propylene Glycol is weighed, squeezes into Agitation Tank, Propylene Glycol final concentration of 9.9%；
(3) 99% polyethylene glycol nonylphenyl ether is weighed, squeezes into Agitation Tank, polyethylene glycol nonylphenyl ether is final concentration of
0.495%；
(5) pure water is weighed, squeezes into Agitation Tank；
(6) stir, obtain chlorhexidine gluconate disinfectant solution.
Present invention also offers a kind of medical material, the medical material disappears comprising foregoing chlorhexidine gluconate
Venom.
Further, the medical material includes that medical wet tissue, medical immersion swab stick, medical immersion dressing, medical disinfecting are wiped
Piece.
Further, the medical material is in process of production all through sterilization treatment, so as to fully ensure that the safety of product
Property and stability, can be used directly after these product independent packagings and dress of unpacking, it is to avoid the cross-contamination of intermediate link and
Infection.
Further, the material of the medical wet tissue is non-woven fabrics.
Further, the size of the non-woven fabrics is 18.0cm × 18.0cm, and the weight of the non-woven fabrics is 180g.
The invention provides a kind of preparation method of foregoing medical wet tissue, the preparation method includes following step
Suddenly：
Foregoing chlorhexidine gluconate disinfectant solution is uniformly sprayed onto into non-woven fabrics up to saturation, you can be prepared from
The medical wet tissue of the present invention.
Further, the preparation method of foregoing medical wet tissue comprises the steps：
(1) non-woven fabrics of the size for 18.0cm × 18.0cm are prepared, weight is 180g；
(2) every block of non-woven fabrics are uniformly sprayed to saturation with the foregoing chlorhexidine gluconate disinfectant solution of 500mg, obtain
Medical wet tissue；
(3) the medical wet tissue aseptic packaging that step (2) is obtained.
The advantages of the present invention：
Chlorhexidine gluconate disinfectant solution stability prepared by the present invention is high, high temperature resistant, wide spectrum, long-acting, non-stimulated nature and flavor,
Safety non-toxic, human body can be widely used in hospital, hotel, service occupation, public place, family etc., with good without allergy
Market prospect.
Specific embodiment
With reference to embodiment, the present invention is further detailed explanation.Following examples be merely to illustrate the present invention and
It is not used in restriction the scope of the present invention.
The preparation of 1 chlorhexidine gluconate disinfectant solution of embodiment
As a example by preparing 100 kilograms of disinfectant solution
Concretely comprise the following steps：
(1) 10 kilogram of 20% chlorhexidine gluconate is weighed, squeezes into Agitation Tank；
(2) 10 kilogram of 99% Propylene Glycol is weighed, squeezes into Agitation Tank；
(3) 0.5 kilogram of 99% polyethylene glycol nonylphenyl ether is weighed, squeezes into Agitation Tank；
(4) 40 kilogram of 75% ethanol is weighed, squeezes into Agitation Tank；
(5) 39.5 kilograms of pure water are weighed, squeezes into Agitation Tank；
(6) stir 5 minutes, into chlorhexidine gluconate disinfectant solution.
The preparation of 2 chlorhexidine gluconate disinfectant solution of embodiment
As a example by preparing 100 kilograms of disinfectant solution
Concretely comprise the following steps：
(1) 20 kilogram of 20% chlorhexidine gluconate is weighed, squeezes into Agitation Tank；
(2) 10 kilogram of 99% Propylene Glycol is weighed, squeezes into Agitation Tank；
(3) 0.5 kilogram of 99% polyethylene glycol nonylphenyl ether is weighed, squeezes into Agitation Tank；
(4) 69.5 kilograms of pure water are weighed, squeezes into Agitation Tank；
(6) stir 5 minutes, into chlorhexidine gluconate disinfectant solution.
The Oral toxicity test of 3 chlorhexidine gluconate disinfectant solution of embodiment
Method：Take white mice body weight 15-20 gram 30 (male and female half and half), by body weight by dosage for 6g/Kg disinfectant solution from
Observation seven days is administered, as a result without death.Median lethal dose(LD 50) of the chlorhexidine gluconate disinfectant solution of the present invention to white mice
(LD50) more than 6g/Kg, as a result show：The chlorhexidine gluconate disinfectant solution of the present invention belongs to nontoxic level.
The irritation test of 4 chlorhexidine gluconate disinfectant solution of embodiment
Rabbit four is taken, the hair of back spinal column both sides is respectively cut into 3*3cm, take the chlorhexidine gluconate sterilization of the present invention
Liquid 0.5ml, drops on four layers of gauze of 2.5*2.5cm sizes, and gauze is spread on side skin, and opposite side applies drop normal saline
Gauze compare, then gauze is fixed with adhesive plaster and binder, apply four hours after, wash away left drug with warm water, as a result see
Examine 1,24,48,72 it is little smear position dermoreaction, occur without erythema and edema, as a result show：The glucose pickling of the present invention must
Safe disinfectant solution is to no skin irritation.
The bactericidal effect of 5 chlorhexidine gluconate disinfectant solution of embodiment
Method：By the chlorhexidine gluconate disinfectant solution of the present invention according to version in 2002《Disinfection technology standard》Related rule
Surely its killing action to microorganism is studied, is as a result shown：Disinfectant solution acts on 0.5min, to colibacillary average killing logarithm
Value>5.00, the average killing logarithm value to staphylococcus aureuses>5.00, the average killing logarithm value to Candida albicans>
4.00, the average killing logarithm value to Pseudomonas aeruginosa>5.00.As a result show：The chlorhexidine gluconate sterilization of the present invention
Liquid has efficient sterilization.
The stability of 6 chlorhexidine gluconate disinfectant solution of embodiment
In 37 DEG C ± 2 DEG C of temperature, place 12 months under conditions of relative humidity 75% ± 5%, the gluconic acid of the present invention
Every quality index of hibitane disinfectant solution is without significant change.As a result show：The chlorhexidine gluconate disinfectant solution tool of the present invention
There is good stability.
The preparation of 7 sterilizing wet tissue of embodiment
(1) non-woven fabrics of the size for 18.0cm × 18.0cm are prepared, weight is 180g；
(2) every block of non-woven fabrics are uniformly sprayed to saturation with the chlorhexidine gluconate disinfectant solution of the 500mg present invention, are cured
Use wet tissue；
(3) the medical wet tissue aseptic packaging that step (2) is obtained.
100 kilograms of chlorhexidine gluconate disinfectant solution prepared by embodiment 1 or embodiment 2 can be used for 200,000 pieces of preparation and kill
The medical wet tissue of bacterium sterilization.
The explanation of above-described embodiment is only intended to understand the method for the present invention and its core concept.It should be pointed out that for this
For the those of ordinary skill in field, under the premise without departing from the principles of the invention, some improvement can also be carried out to the present invention
And modification, these improve and modification will be also fallen in the protection domain of the claims in the present invention.
Claims (10)
1. a kind of chlorhexidine gluconate disinfectant solution, it is characterised in that the chlorhexidine gluconate disinfectant solution includes component：Eventually
Concentration be 4% chlorhexidine gluconate solution, final concentration of 9.9% Propylene Glycol, final concentration of 0.495% Polyethylene Glycol
Nonylplenyl ether.
2. a kind of chlorhexidine gluconate disinfectant solution, it is characterised in that the chlorhexidine gluconate disinfectant solution is included with the following group
Point：Final concentration of 2% chlorhexidine gluconate solution, final concentration of 9.9% Propylene Glycol, final concentration of 0.495% it is poly-
Ethylene glycol nonylplenyl ether, final concentration of 30% ethanol.
3. the preparation method of the chlorhexidine gluconate disinfectant solution described in claim 1, it is characterised in that the preparation method bag
Include following steps：
(1) 20% chlorhexidine gluconate is weighed, Agitation Tank, chlorhexidine gluconate final concentration of 4% is squeezed into；
(2) 99% Propylene Glycol is weighed, squeezes into Agitation Tank, Propylene Glycol final concentration of 9.9%；
(3) 99% polyethylene glycol nonylphenyl ether is weighed, squeezes into Agitation Tank, polyethylene glycol nonylphenyl ether is final concentration of
0.495%；
(4) pure water is weighed, squeezes into Agitation Tank；
(6) stir, obtain chlorhexidine gluconate disinfectant solution.
4. the preparation method of the chlorhexidine gluconate disinfectant solution described in claim 2, it is characterised in that the preparation method bag
Include following steps：
(1) 20% chlorhexidine gluconate is weighed, Agitation Tank, chlorhexidine gluconate final concentration of 2% is squeezed into；
(2) 99% Propylene Glycol is weighed, squeezes into Agitation Tank, Propylene Glycol final concentration of 9.9%；
(3) 99% polyethylene glycol nonylphenyl ether is weighed, squeezes into Agitation Tank, polyethylene glycol nonylphenyl ether is final concentration of
0.495%；
(4) 75% ethanol is weighed, squeezes into Agitation Tank, ethanol final concentration of 30%；
(5) pure water is weighed, squeezes into Agitation Tank；
(6) stir, obtain chlorhexidine gluconate disinfectant solution.
5. a kind of medical material, it is characterised in that the medical material must comprising the glucose pickling described in claim 1 or 2
Safe disinfectant solution.
6. medical material according to claim 5, it is characterised in that the medical material includes medical wet tissue, medical leaching
Liquid swab stick, medical immersion dressing, medical disinfecting pad.
7. the medical wet tissue described in claim 6, it is characterised in that the material of the wet tissue is non-woven fabrics.
8. the medical wet tissue described in claim 7, it is characterised in that the size of the non-woven fabrics is 18.0cm × 18.0cm, institute
The weight for stating non-woven fabrics is 180g.
9. the preparation method of the medical wet tissue any one of claim 5-8, it is characterised in that the preparation method includes
Following steps：
Chlorhexidine gluconate disinfectant solution described in claim 1 or 2 is uniformly sprayed onto into non-woven fabrics up to saturation, you can prepare
Form the medical wet tissue of the present invention.
10. preparation method according to claim 9, it is characterised in that the preparation method comprises the steps：
(1) non-woven fabrics of the size for 18.0cm × 18.0cm are prepared, weight is 180g；
(2) every block of non-woven fabrics are uniformly sprayed to saturation with the chlorhexidine gluconate disinfectant solution described in 500mg claim 1 or 2,
Obtain medical wet tissue；
(3) the medical wet tissue aseptic packaging that step (2) is obtained.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611160969.0A CN106580939A (en) | 2016-12-15 | 2016-12-15 | Chlorhexidine gluconate disinfectant |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611160969.0A CN106580939A (en) | 2016-12-15 | 2016-12-15 | Chlorhexidine gluconate disinfectant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106580939A true CN106580939A (en) | 2017-04-26 |
Family
ID=58801589
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611160969.0A Pending CN106580939A (en) | 2016-12-15 | 2016-12-15 | Chlorhexidine gluconate disinfectant |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106580939A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5164107A (en) * | 1991-04-25 | 1992-11-17 | Becton, Dickinson And Company | Chlorhexidine composition useful in a surgical scrub |
| CN1391809A (en) * | 2002-08-12 | 2003-01-22 | 杨生 | Skin sterilizing agent before operation |
| CN104338121A (en) * | 2013-07-31 | 2015-02-11 | 青岛艾华隆生物科技有限公司 | Medical safe sterilization disinfectant |
-
2016
- 2016-12-15 CN CN201611160969.0A patent/CN106580939A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5164107A (en) * | 1991-04-25 | 1992-11-17 | Becton, Dickinson And Company | Chlorhexidine composition useful in a surgical scrub |
| CN1391809A (en) * | 2002-08-12 | 2003-01-22 | 杨生 | Skin sterilizing agent before operation |
| CN104338121A (en) * | 2013-07-31 | 2015-02-11 | 青岛艾华隆生物科技有限公司 | Medical safe sterilization disinfectant |
Non-Patent Citations (4)
| Title |
|---|
| 中国轻工业集团生活用纸技术中心: "《中国生活用纸年鉴 2006-2007》", 31 January 2006, 中国石化出版社 * |
| 张余善: "《英汉日用化学工业词汇》", 31 May 1990, 轻工业出版社 * |
| 戴彦榛: "消毒药物的合理选择与应用", 《中国热带医学》 * |
| 陈海燕 等: "《静脉血管通路护理实践指南》", 30 April 2016, 复旦大学出版社 * |
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Application publication date: 20170426 |
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