CN108524602A - A kind of Toutong mixture and preparation method thereof - Google Patents
A kind of Toutong mixture and preparation method thereof Download PDFInfo
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Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/237—Notopterygium
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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- Pharmacology & Pharmacy (AREA)
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Abstract
The invention discloses Toutong mixtures, include the raw material of following parts by weight：Rhizoma Chuanxiong 30；The root of Dahurain angelica 20；Rhizoma Et Radix Notopterygii 15；Chrysanthemum 15；Radix Angelicae Sinensis 15；Ligusticum sinense oliver 10；Radix Salviae Miltiorrhizae 20；The beneficial effects of the invention are as follows：The Toutong mixture combines the pharmacological property of the several kinds of Chinese medicinal materials such as Rhizoma Chuanxiong, the root of Dahurain angelica, Rhizoma Et Radix Notopterygii, chrysanthemum, Radix Angelicae Sinensis, ligusticum sinense oliver, pass through a variety of methods such as clearing liver-fire, calming the liver, strengthening the spleen and reducing phlegm, invigorating QI and blood, enriching kidney essence, promoting blood circulation and removing blood stasis, it is dispelling wind and eliminating dampness, soothing the liver, promoting blood circulation and removing obstruction in channels, various headaches are cured mainly, it is especially dialectical for the headache of diseases caused by external factors ailment said due to cold or exposure and the liver-yang headache.
Description
Technical field
The present invention relates to tcm field, specifically a kind of Toutong mixture and preparation method thereof.
Background technology
Migraine is a kind of common clinical, frequently-occurring disease, shows as head side or bilateral pulsation moderate and severe pain, is sent out
Make that there is incidence height, recurrent exerbation, the touching feature of the course of disease with symptoms such as Nausea and vomiting, photophobia and phonophobias often.Closely
The incidence of Nian Lai, migraine have severely impacted work, the studying and living quality of patient in ascendant trend year by year, to trouble
Person brings great pain.Since modern medicine not yet illustrates the pathogenesis of migraine completely, lack affirming, complete
The therapy of complete or thorough radical cure, can only often do anti symptom treatment.
This disease is attributed to " to have a headache " by motherland's medicine, " intermittent headache ", " migraine ", the scopes such as " migraine ".Drug in doctor trained in Western medicine
The analgesic drug product for the treatment of includes：Non-steroidal anti-inflammatory anodyne, central anodyne and narcotic-based painkillers.Non-steroidal anti-inflammatory relieves pain
Medical instrument is effective in cure definite, is the most-often used anodyne of headache, this kind of drug includes aspirin, cloth without additive advantage
Ibuprofen, indocin, paracetamol, phenylbutazone, rofecoxib, celecoxib etc..It is to represent central anodyne with C16H25NO2, belongs to
It is non-narcotic analgesic in two class psychotropic substances, analgesic effect is eager to excel than general antipyretic analgesic medicine, in being mainly used for, again
The headache of degree degree and various postoperative and cancerous lesion pain etc..It is to represent narcoticness analgesic with the opiates medicine such as morphine, Sauteralgyl
Medicine, analgesic effect is most strong, but being used for a long time can habituation.This kind of drug is only used for patients with advanced cancer.Except this, also part Chinese medicine
Compound headache analgesic medicine, this kind of drug have certain help for alleviating and preventing headache.
Currently, traditional Chinese medicine shows great potential in treating migraine, diagnosis and treatment is carried out using theory of traditional Chinese medical science, is had
Unique treatment advantage, often obtains notable curative effect.The cause of disease of migraine nothing more than diseases caused by external factors and internal injury two major classes, wind, fire,
Phlegm, the stasis of blood, void are its main pathogenics.The sick position of migraine is closely related with three dirty functional disturbance of liver,spleen,kidney in brain network.It will
Migraine is divided into exogenous headache, irascibility headache, the liver-yang headache, phlegm evil headache, headache due to deficiency of vital energy, headache due to deficiency of blood, headache due to the kidney insufficiency, hemostasis
Eight basic card types of headache.Exogenous headache mostly empirical is treated mostly based on evacuation；Beadache with internal injury has void to have reality or actual situation folder
Miscellaneous, treatment is to control in a variety of methods such as clearing liver-fire, calming the liver, strengthening the spleen and reducing phlegm, invigorating QI and blood, enriching kidney essence, promoting blood circulation and removing blood stasis
Then.
Invention content
The purpose of the present invention is to provide Toutong mixtures, to solve the problems mentioned in the above background technology.
To achieve the above object, the present invention provides the following technical solutions：
Toutong mixture includes the raw material of following parts by weight：
Rhizoma Chuanxiong 30；
The root of Dahurain angelica 20；
Rhizoma Et Radix Notopterygii 15；
Chrysanthemum 15；
Radix Angelicae Sinensis 15；
Ligusticum sinense oliver 10；
Radix Salviae Miltiorrhizae 20.
The preparation method of the Toutong mixture, includes the following steps：
Step 1: after Rhizoma Chuanxiong adds water temperature to soak 30 minutes, decoction is secondary, 2 hours every time, collecting decoction, and filtration, filtrate is concentrated into 70
The clear cream that~80 DEG C of relative densities are 1.20~1.25, being slowly added into ethyl alcohol after cooling makes alcohol content up to 60~80%, fully stirs
It mixes, stands 12 hours, leaching supernatant adjusts pH value with sodium hydroxide solution, and residue adds 75% appropriate amount of ethanol, stirs evenly, and stands 12
Hour, filtration merge ethanol, recycling ethyl alcohol to no alcohol taste, and 5-10 times of addition measures water water and sinks, filtration, filtrate concentration, and decompression is done
It is dry, it is ground into fine powder, obtains Rhizoma Chuanxiong extract.
Step 2: being added water to cook after the root of Dahurain angelica is crushed three times, first and second time 2 hours each, and third time 1 hour merges and decocts
Liquid, filtration, filtrate is concentrated into the clear cream that 70~80 DEG C of relative densities are 1.15~1.25, and addition hydrochloric acid is molten at 70~80 DEG C
Liquid adjusts pH value to 1.0~3.0, keeps the temperature 1 hour, stands 12 hours, and filtration, the water that precipitation add weight is measured than 8~10 times uses hydrogen
Sodium hydroxide solution adjusts pH value to 6.0~8.0, then ethyl alcohol is added to make alcohol content up to 40~60%, is stirred to dissolve, and filters, and filtrate is used
Hydrochloric acid solution adjusts pH value and keeps the temperature 1 hour to 1.0~2.0,50 DEG C, stands 10 hours, filtration, precipitation is washed till pH value with ethyl alcohol and is
6.0~8.0, recycling ethyl alcohol obtains Angelica Dahurica extract.
Step 3: after Rhizoma Et Radix Notopterygii adds water temperature to soak 30 minutes, decocts secondary, 2 hours first times, second 1 hour, merge and decoct
Liquid, filtration, filtrate are concentrated into the clear cream that 70~80 DEG C of relative densities are 1.20~1.25, and being slowly added into ethyl alcohol after cooling makes containing alcohol
Amount is sufficiently stirred up to 60~80%, stands 12 hours, leaching supernatant, adjusts pH value with sodium hydroxide solution, residue adds 75% second
Appropriate alcohol stirs evenly, standing 12 hours, filtration, merges ethanol, recycling ethyl alcohol to no alcohol taste, and 5-10 times of addition measures water water and sinks, filter
It crosses, filtrate concentration is dried under reduced pressure, is ground into fine powder, obtains notopterygium root extract.
Step 4: after chrysanthemum with water temperature is soaked 30 minutes, decocts secondary, 2 hours first times, second 1 hour, merge and decoct
Liquid, filtration, filtrate are concentrated into the clear cream that 70~80 DEG C of relative densities are 1.20~1.25, and being slowly added into ethyl alcohol after cooling makes containing alcohol
Amount is sufficiently stirred up to 60~80%, stands 12 hours, leaching supernatant, adjusts pH value with sodium hydroxide solution, residue adds 75% second
Appropriate alcohol stirs evenly, standing 12 hours, filtration, merges ethanol, recycling ethyl alcohol to no alcohol taste, and 5-10 times of addition measures water water and sinks, filter
It crosses, filtrate concentration is dried under reduced pressure, is ground into fine powder, obtains chrysanthemum extract.
Step 5: after Radix Angelicae Sinensis adds water temperature to soak 30 minutes, decocts secondary, 2 hours first times, second 1 hour, merge and decoct
Liquid, filtration, filtrate are concentrated into the clear cream that 70~80 DEG C of relative densities are 1.20~1.25, and being slowly added into ethyl alcohol after cooling makes containing alcohol
Amount is sufficiently stirred up to 60~80%, stands 12 hours, leaching supernatant, adjusts pH value with sodium hydroxide solution, residue adds 75% second
Appropriate alcohol stirs evenly, standing 12 hours, filtration, merges ethanol, recycling ethyl alcohol to no alcohol taste, and 5-10 times of addition measures water water and sinks, filter
It crosses, filtrate concentration is dried under reduced pressure, is ground into fine powder, obtains angelica extract.
Step 6: after ligusticum sinense oliver water temperature is soaked 30 minutes, decoct secondary, 2 hours first times, second 1 hour, collecting decoction,
Filtration, filtrate are concentrated into the clear cream that 70~80 DEG C of relative densities are 1.20~1.25, and being slowly added into ethyl alcohol after cooling makes alcohol content
It up to 60~80%, is sufficiently stirred, stands 12 hours, leaching supernatant adjusts pH value with sodium hydroxide solution, and residue adds 75% ethyl alcohol
In right amount, it stirs evenly, standing 12 hours, filtration, merges ethanol, recycling ethyl alcohol to no alcohol taste, 5-10 times of addition measures water water and sinks, filter
It crosses, filtrate concentration is dried under reduced pressure, is ground into fine powder, obtains ligusticum sinense oliver extract.
Step 7: after Radix Salviae Miltiorrhizae water temperature is soaked 30 minutes, decoct secondary, 2 hours first times, second 1 hour, collecting decoction,
Filtration, filtrate are concentrated into the clear cream that 70~80 DEG C of relative densities are 1.20~1.25, and being slowly added into ethyl alcohol after cooling makes alcohol content
It up to 60~80%, is sufficiently stirred, stands 12 hours, leaching supernatant adjusts pH value with sodium hydroxide solution, and residue adds 75% ethyl alcohol
In right amount, it stirs evenly, standing 12 hours, filtration, merges ethanol, recycling ethyl alcohol to no alcohol taste, 5-10 times of addition measures water water and sinks, filter
It crosses, filtrate concentration is dried under reduced pressure, is ground into fine powder, obtains Salvia root P.E.
Step 8: Rhizoma Chuanxiong extract, Angelica Dahurica extract, notopterygium root extract, chrysanthemum extract, Radix Angelicae Sinensis are extracted by formula ratio
Object, ligusticum sinense oliver extract, Salvia root P.E mixing, add appropriate amount of water, are stirred until homogeneous, and pH value is adjusted to 6.0 with sodium hydroxide solution
~8.0, it stirs evenly, filters, 5% 101- fining agents are added in filtrate, stir evenly, and place after ten minutes, auxiliary agent suspension is added, stirs evenly,
It being filtered after standing 12 hours, filtrate adds 5% 101- fining agents and auxiliary agent suspension, and adding proportion and method are same for the first time,
It is filtered after standing 12 hours, filtrate adds sucrose, is stirred to dissolve, and adjusts pH value to 6.0~8.0 with sodium hydroxide solution, adds water
Dilution, liquid total amount is made, stirs evenly, filter, it is filling, sterilizing to get.
Mixture is obtained in preferred step 8 to be dispensed into medicine bottle, packing specification is 100ml/ bottles.
Instructions of taking：20ml, three times a day.
Compared with prior art, the beneficial effects of the invention are as follows：The Toutong mixture combines Rhizoma Chuanxiong, the root of Dahurain angelica, Rhizoma Et Radix Notopterygii, chrysanthemum
The pharmacological property of the several kinds of Chinese medicinal materials such as flower, Radix Angelicae Sinensis, ligusticum sinense oliver is filled out by clearing liver-fire, calming the liver, strengthening the spleen and reducing phlegm, invigorating QI and blood, kidney-nourishing
A variety of methods such as smart, promoting blood circulation and removing blood stasis, it is dispelling wind and eliminating dampness, soothing the liver, promoting blood circulation and removing obstruction in channels, various headaches are cured mainly, especially dialectical is diseases caused by external factors ailment said due to cold or exposure
Headache and the liver-yang headache.
Specific implementation mode
The technical solution of this patent is described in more detail With reference to embodiment.
Toutong mixture includes the raw material of following parts by weight：
Rhizoma Chuanxiong 30；
The root of Dahurain angelica 20；
Rhizoma Et Radix Notopterygii 15；
Chrysanthemum 15；
Radix Angelicae Sinensis 15；
Ligusticum sinense oliver 10；
Radix Salviae Miltiorrhizae 20.
The pharmaceutical characteristic of each bulk pharmaceutical chemicals of the present invention is as follows:
Rhizoma Chuanxiong is usually used in blood-activating and qi-promoting, and wind-expelling pain-stopping, Rhizoma Chuanxiong pungent-warm perfume (or spice) is dry, walks without keeping, can go it is scattered, uplink up to mountain peak push up；
Enter blood system again, downlink is up to the sea of blood.Promoting blood circulation effect is extensive, suitable for the various illnesss of stagnation of blood stasis；Wind-expelling pain-stopping, effectiveness is very
It is good, the diseases such as head wind headache, arthralgia pain due to rheumatism can be controlled.Former times people call Rhizoma Chuanxiong be blood in gas medicine, nearly say its reside it is pungent dissipate, Xie Yu, it is sensible, only
The functions such as pain.
The root of Dahurain angelica is used as medicine with root, the functions such as the dehumidifying that gets rid of illness, apocenosis myogenic, promoting blood circulation and stopping pain.Cure mainly anemofrigid cold, headache, nose
Scorching, toothache.The diseases such as leukorrhea with reddish discharge, pain furuncle poison.
Its is warm-natured for Rhizoma Et Radix Notopterygii, relieving exterior syndrome and dispelling cold, dispellieg cold and dampness, for catching cold, headache and adiapneustia, cold-dampness numbness, upper limb rheumatalgia pain.
Chrysanthemum bitter, sweet, cold nature have relieve heat heat-clearing, flat liver improving eyesight, clearing heat and detoxicating effect.
Radix Angelicae Sinensis has replenishing and activating blood, menstruction regulating and pain relieving, the effect of relaxing bowel.It is usually used in blood deficiency chlorosis, dizziness palpitaition, menstruation
It is uncomfortable, closed dysmenorrhea, asthenia cold abdominalgia, arthralgia pain due to rheumatism, injury from falling down, ulcer sores, dry constipation of intestines.Prepared RADIX ANGELICAE SINENSIS with yellow rice wine invigorate blood circulation.With
In closed dysmenorrhea, arthralgia pain due to rheumatism, injury from falling down.
Ligusticum sinense oliver is used for anemofrigid cold, top of the head pain.Ligusticum sinense oliver pungent-warm perfume (or spice) is dry, and nature and flavor all rise, and medicine gesture is magnificent, Starch 1500 mountain peak top, with
Diverging Taiyang channel wind-cold damp pathogen is good at, therefore with sun chill is controlled, it follows through upper criminal, symptoms include headache, nasal obstruction, parietal headache are notably, such as god
Art dissipates；If catching cold damp evil, all over the body to the greatest extent bitterly, and often it is equal with windproof, Radix Angelicae Pubescentis, the root of Chinese clematis, rhizoma atractylodis and uses, with expelling wind and clearing away cold, remove
Wet analgesic.
The effect of Radix Salviae Miltiorrhizae has promoting blood circulation, inducing meastruation to relieve menalgia, relieving restlessness that clears away heart-fire, cool blood to disappear carbuncle.For chest impediment and cardialgia, the gastral cavity abdomen side of body
Bitterly, lump in the abdomen lump in the abdomen is gathered, hot numbness pain, dysphoria and insomnia, irregular menstruation, dysmenorrhoea Amenorrhea, sore swell and ache curative.
Step 1: after Rhizoma Chuanxiong adds water temperature to soak 30 minutes, decoction is secondary, 2 hours every time, collecting decoction, filtration, filtrate concentration
Being slowly added into ethyl alcohol to the clear cream that 70~80 DEG C of relative densities are 1.20~1.25, after cooling makes alcohol content up to 60~80%, fully
Stirring stands 12 hours, leaching supernatant, and pH value is adjusted with sodium hydroxide solution, and residue adds 75% appropriate amount of ethanol, stirs evenly, and stands
12 hours, filtration merged ethanol, recycling ethyl alcohol to no alcohol taste, and 5-10 times of addition measures water water and sinks, filtration, filtrate concentration, decompression
It is dried, crushed into fine powder, obtains Rhizoma Chuanxiong extract.
Step 2: being added water to cook after the root of Dahurain angelica is crushed three times, first and second time 2 hours each, and third time 1 hour merges and decocts
Liquid, filtration, filtrate is concentrated into the clear cream that 70~80 DEG C of relative densities are 1.15~1.25, and addition hydrochloric acid is molten at 70~80 DEG C
Liquid adjusts pH value to 1.0~3.0, keeps the temperature 1 hour, stands 12 hours, and filtration, the water that precipitation add weight is measured than 8~10 times uses hydrogen
Sodium hydroxide solution adjusts pH value to 6.0~8.0, then ethyl alcohol is added to make alcohol content up to 40~60%, is stirred to dissolve, and filters, and filtrate is used
Hydrochloric acid solution adjusts pH value and keeps the temperature 1 hour to 1.0~2.0,50 DEG C, stands 10 hours, filtration, precipitation is washed till pH value with ethyl alcohol and is
6.0~8.0, recycling ethyl alcohol obtains Angelica Dahurica extract.
Step 3: after Rhizoma Et Radix Notopterygii adds water temperature to soak 30 minutes, decocts secondary, 2 hours first times, second 1 hour, merge and decoct
Liquid, filtration, filtrate are concentrated into the clear cream that 70~80 DEG C of relative densities are 1.20~1.25, and being slowly added into ethyl alcohol after cooling makes containing alcohol
Amount is sufficiently stirred up to 60~80%, stands 12 hours, leaching supernatant, adjusts pH value with sodium hydroxide solution, residue adds 75% second
Appropriate alcohol stirs evenly, standing 12 hours, filtration, merges ethanol, recycling ethyl alcohol to no alcohol taste, and 5-10 times of addition measures water water and sinks, filter
It crosses, filtrate concentration is dried under reduced pressure, is ground into fine powder, obtains notopterygium root extract.
Step 4: after chrysanthemum with water temperature is soaked 30 minutes, decocts secondary, 2 hours first times, second 1 hour, merge and decoct
Liquid, filtration, filtrate are concentrated into the clear cream that 70~80 DEG C of relative densities are 1.20~1.25, and being slowly added into ethyl alcohol after cooling makes containing alcohol
Amount is sufficiently stirred up to 60~80%, stands 12 hours, leaching supernatant, adjusts pH value with sodium hydroxide solution, residue adds 75% second
Appropriate alcohol stirs evenly, standing 12 hours, filtration, merges ethanol, recycling ethyl alcohol to no alcohol taste, and 5-10 times of addition measures water water and sinks, filter
It crosses, filtrate concentration is dried under reduced pressure, is ground into fine powder, obtains chrysanthemum extract.
Step 5: after Radix Angelicae Sinensis adds water temperature to soak 30 minutes, decocts secondary, 2 hours first times, second 1 hour, merge and decoct
Liquid, filtration, filtrate are concentrated into the clear cream that 70~80 DEG C of relative densities are 1.20~1.25, and being slowly added into ethyl alcohol after cooling makes containing alcohol
Amount is sufficiently stirred up to 60~80%, stands 12 hours, leaching supernatant, adjusts pH value with sodium hydroxide solution, residue adds 75% second
Appropriate alcohol stirs evenly, standing 12 hours, filtration, merges ethanol, recycling ethyl alcohol to no alcohol taste, and 5-10 times of addition measures water water and sinks, filter
It crosses, filtrate concentration is dried under reduced pressure, is ground into fine powder, obtains angelica extract.
Step 6: after ligusticum sinense oliver water temperature is soaked 30 minutes, decoct secondary, 2 hours first times, second 1 hour, collecting decoction,
Filtration, filtrate are concentrated into the clear cream that 70~80 DEG C of relative densities are 1.20~1.25, and being slowly added into ethyl alcohol after cooling makes alcohol content
It up to 60~80%, is sufficiently stirred, stands 12 hours, leaching supernatant adjusts pH value with sodium hydroxide solution, and residue adds 75% ethyl alcohol
In right amount, it stirs evenly, standing 12 hours, filtration, merges ethanol, recycling ethyl alcohol to no alcohol taste, 5-10 times of addition measures water water and sinks, filter
It crosses, filtrate concentration is dried under reduced pressure, is ground into fine powder, obtains ligusticum sinense oliver extract.
Step 7: after Radix Salviae Miltiorrhizae water temperature is soaked 30 minutes, decoct secondary, 2 hours first times, second 1 hour, collecting decoction,
Filtration, filtrate are concentrated into the clear cream that 70~80 DEG C of relative densities are 1.20~1.25, and being slowly added into ethyl alcohol after cooling makes alcohol content
It up to 60~80%, is sufficiently stirred, stands 12 hours, leaching supernatant adjusts pH value with sodium hydroxide solution, and residue adds 75% ethyl alcohol
In right amount, it stirs evenly, standing 12 hours, filtration, merges ethanol, recycling ethyl alcohol to no alcohol taste, 5-10 times of addition measures water water and sinks, filter
It crosses, filtrate concentration is dried under reduced pressure, is ground into fine powder, obtains Salvia root P.E.
Step 8: Rhizoma Chuanxiong extract, Angelica Dahurica extract, notopterygium root extract, chrysanthemum extract, Radix Angelicae Sinensis are extracted by formula ratio
Object, ligusticum sinense oliver extract, Salvia root P.E mixing, add appropriate amount of water, are stirred until homogeneous, and pH value is adjusted to 6.0 with sodium hydroxide solution
~8.0, it stirs evenly, filters, 5% 101- fining agents are added in filtrate, stir evenly, and place after ten minutes, auxiliary agent suspension is added, stirs evenly,
It being filtered after standing 12 hours, filtrate adds 5% 101- fining agents and auxiliary agent suspension, and adding proportion and method are same for the first time,
It is filtered after standing 12 hours, filtrate adds sucrose, is stirred to dissolve, and adjusts pH value to 6.0~8.0 with sodium hydroxide solution, adds water
Dilution, liquid total amount is made, stirs evenly, filter, it is filling, sterilizing to get.
Mixture is obtained in preferred step 8 to be dispensed into medicine bottle, packing specification is 100ml/ bottles.
Instructions of taking：20ml, three times a day.
The better embodiment of this patent is explained in detail above, but this patent is not limited to above-mentioned embodiment party
Formula, one skilled in the relevant art within the scope of knowledge, can also be under the premise of not departing from this patent objective
It makes a variety of changes.
Claims (4)
1. a kind of Toutong mixture, which is characterized in that include the raw material of following parts by weight：
Rhizoma Chuanxiong 30；
The root of Dahurain angelica 20；
Rhizoma Et Radix Notopterygii 15；
Chrysanthemum 15；
Radix Angelicae Sinensis 15；
Ligusticum sinense oliver 10；
Radix Salviae Miltiorrhizae 20.
2. the preparation method of the Toutong mixture, which is characterized in that include the following steps：
Step 1: after Rhizoma Chuanxiong adds water temperature to soak 30 minutes, decoction is secondary, 2 hours every time, collecting decoction, and filtration, filtrate is concentrated into 70
The clear cream that~80 DEG C of relative densities are 1.20~1.25, being slowly added into ethyl alcohol after cooling makes alcohol content up to 60~80%, fully stirs
It mixes, stands 12 hours, leaching supernatant adjusts pH value with sodium hydroxide solution, and residue adds 75% appropriate amount of ethanol, stirs evenly, and stands 12
Hour, filtration merge ethanol, recycling ethyl alcohol to no alcohol taste, and 5-10 times of addition measures water water and sinks, filtration, filtrate concentration, and decompression is done
It is dry, it is ground into fine powder, obtains Rhizoma Chuanxiong extract；
Step 2: being added water to cook after the root of Dahurain angelica is crushed three times, first and second time 2 hours each, third time 1 hour, collecting decoction, filter
It crosses, filtrate is concentrated into the clear cream that 70~80 DEG C of relative densities are 1.15~1.25, and hydrochloric acid solution tune is added at 70~80 DEG C
PH value is saved to 1.0~3.0,1 hour is kept the temperature, stands 12 hours, filtration, the water that precipitation add weight is measured than 8~10 times uses hydroxide
Sodium solution adjusts pH value to 6.0~8.0, then ethyl alcohol is added to make alcohol content up to 40~60%, is stirred to dissolve, and filters, filtrate hydrochloric acid
Solution adjust pH value to 1.0~2.0,50 DEG C keep the temperature 1 hour, stand 10 hours, filtration, precipitation with ethyl alcohol be washed till pH value be 6.0
~8.0, recycling ethyl alcohol obtains Angelica Dahurica extract；
Step 3: after Rhizoma Et Radix Notopterygii adds water temperature to soak 30 minutes, decoct secondary, 2 hours first times, second 1 hour, collecting decoction, filter
It crosses, filtrate is concentrated into the clear cream that 70~80 DEG C of relative densities are 1.20~1.25, and being slowly added into ethyl alcohol after cooling makes alcohol content reach
60~80%, it is sufficiently stirred, stands 12 hours, leaching supernatant adjusts pH value with sodium hydroxide solution, and residue adds 75% ethyl alcohol suitable
It measures, stirs evenly, standing 12 hours, filtration merges ethanol, recycling ethyl alcohol to no alcohol taste, and 5-10 times of addition measures water water and sinks, filtration,
Filtrate concentrates, and is dried under reduced pressure, is ground into fine powder, obtains notopterygium root extract；
Step 4: after chrysanthemum with water temperature is soaked 30 minutes, decoct secondary, 2 hours first times, second 1 hour, collecting decoction, filter
It crosses, filtrate is concentrated into the clear cream that 70~80 DEG C of relative densities are 1.20~1.25, and being slowly added into ethyl alcohol after cooling makes alcohol content reach
60~80%, it is sufficiently stirred, stands 12 hours, leaching supernatant adjusts pH value with sodium hydroxide solution, and residue adds 75% ethyl alcohol suitable
It measures, stirs evenly, standing 12 hours, filtration merges ethanol, recycling ethyl alcohol to no alcohol taste, and 5-10 times of addition measures water water and sinks, filtration,
Filtrate concentrates, and is dried under reduced pressure, is ground into fine powder, obtains chrysanthemum extract；
Step 5: after Radix Angelicae Sinensis adds water temperature to soak 30 minutes, decoct secondary, 2 hours first times, second 1 hour, collecting decoction, filter
It crosses, filtrate is concentrated into the clear cream that 70~80 DEG C of relative densities are 1.20~1.25, and being slowly added into ethyl alcohol after cooling makes alcohol content reach
60~80%, it is sufficiently stirred, stands 12 hours, leaching supernatant adjusts pH value with sodium hydroxide solution, and residue adds 75% ethyl alcohol suitable
It measures, stirs evenly, standing 12 hours, filtration merges ethanol, recycling ethyl alcohol to no alcohol taste, and 5-10 times of addition measures water water and sinks, filtration,
Filtrate concentrates, and is dried under reduced pressure, is ground into fine powder, obtains angelica extract；
Step 6: after ligusticum sinense oliver water temperature is soaked 30 minutes, decoct secondary, 2 hours first times, second 1 hour, collecting decoction, filtration,
Filtrate is concentrated into the clear cream that 70~80 DEG C of relative densities are 1.20~1.25, be slowly added into after cooling ethyl alcohol make alcohol content up to 60~
80%, it is sufficiently stirred, stands 12 hours, leaching supernatant adjusts pH value with sodium hydroxide solution, and residue adds 75% appropriate amount of ethanol,
It stirs evenly, standing 12 hours, filtration, merges ethanol, recycling ethyl alcohol to no alcohol taste, 5-10 times of addition measures water water and sinks, filtration, filtrate
Concentration, is dried under reduced pressure, is ground into fine powder, obtain ligusticum sinense oliver extract；
Step 7: after Radix Salviae Miltiorrhizae water temperature is soaked 30 minutes, decoct secondary, 2 hours first times, second 1 hour, collecting decoction, filtration,
Filtrate is concentrated into the clear cream that 70~80 DEG C of relative densities are 1.20~1.25, be slowly added into after cooling ethyl alcohol make alcohol content up to 60~
80%, it is sufficiently stirred, stands 12 hours, leaching supernatant adjusts pH value with sodium hydroxide solution, and residue adds 75% appropriate amount of ethanol,
It stirs evenly, standing 12 hours, filtration, merges ethanol, recycling ethyl alcohol to no alcohol taste, 5-10 times of addition measures water water and sinks, filtration, filtrate
Concentration, is dried under reduced pressure, is ground into fine powder, obtain Salvia root P.E；
Step 8: by formula ratio by Rhizoma Chuanxiong extract, Angelica Dahurica extract, notopterygium root extract, chrysanthemum extract, angelica extract,
Ligusticum sinense oliver extract, Salvia root P.E mixing, add appropriate amount of water, are stirred until homogeneous, with sodium hydroxide solution adjust pH value to 6.0~
8.0, it stirs evenly, filters, 5% 101- fining agents are added in filtrate, stir evenly, and place after ten minutes, auxiliary agent suspension is added, stirs evenly, quiet
It is filtered after setting 12 hours, filtrate adds 5% 101- fining agents and auxiliary agent suspension, and adding proportion and method are quiet with first time
It is filtered after setting 12 hours, filtrate adds sucrose, is stirred to dissolve, and adjusts pH value to 6.0~8.0 with sodium hydroxide solution, adds water dilute
Release, liquid total amount be made, stirs evenly, filter, it is filling, sterilizing to get.
3. the preparation method of Toutong mixture according to claim 2, which is characterized in that obtain mixture in preferred step 8
It is dispensed into medicine bottle, packing specification is 100ml/ bottles.
4. Toutong mixture according to claim 3, which is characterized in that instructions of taking：20ml, three times a day.
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| CN101357161A (en) * | 2008-08-22 | 2009-02-04 | 江红旗 | External medicine for treating vascular headache and preparation method thereof |
| CN101780131A (en) * | 2010-03-26 | 2010-07-21 | 鲍旭刚 | Drug for treating headache and preparation method thereof |
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Application publication date: 20180914 |