CN108498626A - Defaecation or composition, preparation method, purposes and its preparation for adjusting intestinal flora - Google Patents
Defaecation or composition, preparation method, purposes and its preparation for adjusting intestinal flora Download PDFInfo
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- CN108498626A CN108498626A CN201810385989.0A CN201810385989A CN108498626A CN 108498626 A CN108498626 A CN 108498626A CN 201810385989 A CN201810385989 A CN 201810385989A CN 108498626 A CN108498626 A CN 108498626A
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- KXGCNMMJRFDFNR-WDRJZQOASA-N linaclotide Chemical class C([C@H](NC(=O)[C@@H]1CSSC[C@H]2C(=O)N[C@H]3CSSC[C@H](N)C(=O)N[C@H](C(N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N2)=O)CSSC[C@H](NC(=O)[C@H](C)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(N)=O)NC3=O)C(=O)N[C@H](C(NCC(=O)N1)=O)[C@H](O)C)C(O)=O)C1=CC=C(O)C=C1 KXGCNMMJRFDFNR-WDRJZQOASA-N 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 235000011477 liquorice Nutrition 0.000 description 1
- 229960000345 lubiprostone Drugs 0.000 description 1
- WGFOBBZOWHGYQH-MXHNKVEKSA-N lubiprostone Chemical compound O1[C@](C(F)(F)CCCC)(O)CC[C@@H]2[C@@H](CCCCCCC(O)=O)C(=O)C[C@H]21 WGFOBBZOWHGYQH-MXHNKVEKSA-N 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 238000004949 mass spectrometry Methods 0.000 description 1
- 238000001819 mass spectrum Methods 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 239000010446 mirabilite Substances 0.000 description 1
- 239000003595 mist Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 239000006199 nebulizer Substances 0.000 description 1
- XKLJHFLUAHKGGU-UHFFFAOYSA-N nitrous amide Chemical compound ON=N XKLJHFLUAHKGGU-UHFFFAOYSA-N 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 230000008855 peristalsis Effects 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229910052573 porcelain Inorganic materials 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 229940069328 povidone Drugs 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000001543 purgative effect Effects 0.000 description 1
- 230000009103 reabsorption Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 208000020615 rectal carcinoma Diseases 0.000 description 1
- 201000010727 rectal prolapse Diseases 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 229940080313 sodium starch Drugs 0.000 description 1
- 238000010025 steaming Methods 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 229910021642 ultra pure water Inorganic materials 0.000 description 1
- 239000012498 ultrapure water Substances 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 238000002137 ultrasound extraction Methods 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 238000003809 water extraction Methods 0.000 description 1
- 235000015099 wheat brans Nutrition 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/733—Fructosans, e.g. inulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/46—Eucommiaceae (Eucommia family), e.g. hardy rubber tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
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- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
The invention discloses a kind of defaecation or composition, preparation method, purposes and its preparations of adjusting intestinal flora.Defaecation provided by the invention or the composition for adjusting intestinal flora include following components：5 parts~25 parts of 15 parts~55 parts of Radix Rehmanniae water extract, 5 parts~25 parts of folium cortex eucommiae water extract, 5 parts~25 parts of angelica root water extract and Mulberry fruit water extract.The composition is free of anthraquinone component, safe without toxic side effect and reasonable price, can reach the excellent effect for relaxing bowel and adjusting intestinal flora effect.
Description
Technical field
The present invention provides a kind of defaecation or composition, preparation method, purposes and its preparations of adjusting intestinal flora.
Background technology
Currently, epidemiological survey data is shown, China chronic constipation crowd is widely present in each kind of groups, for example,
In children, university student and old man group；And the constipation probability of women is 1.22~4.56 times of male.
Also, studies have shown that constipation crowd and healthy population compare, Bifidobacterium in constipation group crowd's excrement, bacteroid,
The beneficial bacteriums such as Bacillus acidi lactici substantially reduce, and harmful bacterias, the conditioned pathogen such as corrupt Fusobacterium, clostridium, enterobacteria
Significantly increase.
There is serious enteric flora disturbance, nitrosamine, phenols, the Ammonia of a large amount of harmful bacterias generations in prolonged constipation patient
Or the carcinogens such as azobenzene, it cannot excrete in time, breast cancer is induced into human blood by intestinal absorption, it is long-term directly
The toxin that contact various bacteria generates can cause intestinal mucosa inflammation, canceration to be colon and rectum carcinoma.Long-term chronic constipation leads to intestines
Road flora imbalance, some vitamin synthesis is insufficient, causes immunity degradation, neurasthenia, depression etc..Long-term chronic constipation also may be used
It can cause halitosis, skin splash, have blood in stool, cause hemorrhoid, anal fissure, rectal prolapse, apoplexy etc..
Gastrointestinal tissue of world constipation guide proposes the prevention and treatment to chronic constipation within 2010, mainly there is five major class medicines
Object：Including such as psyllium seed, wheat bran, the bulk-forming drug of methylcellulose class；Such as polyethylene glycol, lactulose (oligomeric disaccharides), sulphur
Sour magnesium, the penetrating pharmaceuticals such as saltcake；Such as phenolphthalein, castor oil, Bisacody, Anthraquinones dripping of irritant drugs；Highly selective 5- hydroxyls
4 receptor stimulating agent Pu Luka Billy's class motivator drugs of tryptamines；And Lubiprostone 1 and Linaclotide class promote intestinal fluid secretion medicine
Object.
Currently, health food, drug in China market for preventing and treating constipation, mainly contain rheum officinale, the fleece-flower root, reed
The raw materials such as luxuriant growth, cassia seed, folium sennae, such raw material contain higher anthraquinone component, by stimulating colonic peristalsis, and reduction
Reabsorption of the large intestine to moisture, and play the effect to relax bowel.Such components long-time high dose uses, and may cause colon
Blacking.
For example, Chinese patent application CN103083459A, a kind of compound Chinese medicinal preparation and preparation method thereof for treating constipation
And application.Used in the invention ochre, Radix Angelicae Sinensis, prepared rehmannia root, the compound of glauber-salt and liquorice, glutinous rehmannia, fiery fiber crops, rheum officinale, peach kernel, safflower, cimicifugae foetidae and
Radix Glycyrrhizae.But rheum officinale is the material of purgatives medicine containing Anthraquinones in the invention, and ochre is used, containing heavy metal component, tool is used for a long time
There is larger security risk.
In addition, Chinese patent application CN106942724A, has the composition and its system for adjusting intestinal microflora effect
Preparation Method and application.The invention uses three taste material combination of glutinous rehmannia, Poria cocos and ginseng, and to constipation, abdomen rises, the intestines problems such as diarrhea
With good adjusting and healthcare function.But the invention uses ginseng raw material, cost is higher, and in addition real heat constipation is suffered from
Person, using effect are poor.
Therefore it develops a without anthraquinone component and of reasonable cost for preventing and treating constipation, and can adjust
The new product of intestinal flora is particularly significant.
Invention content
The technical problem to be solved by the present invention is to prevent and treat constipation in the prior art to overcome, and adjust intestines
Containing the anthraquinone component of side effect or the problem that cost of material is high is also easy to produce in the product of road flora, to provide one kind
Defaecation, composition, preparation method, purposes and its preparation for adjusting intestinal flora.Without anthraquinone component, safety in the composition
It has no toxic side effect and reasonable price, the excellent effect for relaxing bowel and adjusting intestinal flora effect can be reached.
The present invention is to solve above-mentioned technical problem by the following technical programs.
The present invention provides a kind of Chinese medicine compositions, and it includes following components：15 parts~55 parts of Radix Rehmanniae water extract, Cortex Eucommiae
5 parts~25 parts of 5 parts~25 parts of leaf water extract, 5 parts~25 parts of angelica root water extract and Mulberry fruit water extract.
In the present invention, the "comprising" refers to that also may include other activity or non-active ingredient in the Chinese medicine composition；
The use of " activity or the non-active ingredient " should not influence the basic training of the Chinese medicine composition to meet drug matching principle
Effect, and the compatibility relationship for not destroying in the Chinese medicine composition " monarch minister, helps, makes " is basic principle；For example, it is described activity at
It is divided into prebiotics；Such as the non-active ingredient is pharmaceutical carrier.
In the present invention, in the Radix Rehmanniae water extract content of stachyose can be 15%~55% (such as 15%~
50%)；Percentage is the mass percent that stachyose takes up an area xanthorrhiza water extract gross mass.
In the present invention, the content of the chlorogenic acid in the folium cortex eucommiae water extract can be 3%~10% (such as 2%~
12%)；Percentage is the mass percent that chlorogenic acid accounts for folium cortex eucommiae water extract gross mass.
In the present invention, the dosage of the Radix Rehmanniae water extract can be 15 parts~45 parts (such as 30 parts~35 parts).
In the present invention, the dosage of the folium cortex eucommiae water extract can be 5 parts~15 parts (such as 5 parts~10 parts).
In the present invention, the dosage of the angelica root water extract can be 5 parts~15 parts (such as 5 parts~10 parts).
In the present invention, the dosage of the Mulberry fruit water extract can be 5 parts~15 parts (such as 5 parts~10 parts).
In the present invention, the Chinese medicine composition also may include prebiotics.
Wherein, the prebiotics dosage can be 0 part~70 parts, but not be 0；(such as 25 parts~50 parts, then such as 25 parts~
40 parts).
In the present invention, the prebiotics can be prebiotics conventional in the art, such as oligosaccharides prebiotics；It is described low
Glycan class prebiotics can be selected from stachyose, oligofructose, xylo-oligosaccharide, galactooligosaccharide, oligoisomaltose, gossypose and chrysanthemum
It is one or more in powder.
In the present invention, the Radix Rehmanniae water extract, folium cortex eucommiae water extract, angelica root water extract and Mulberry fruit water extract are general
For the Radix Rehmanniae water extract of drying regime, folium cortex eucommiae water extract, angelica root water extract and Mulberry fruit water extract.In this field, institute
Water content in Radix Rehmanniae water extract, folium cortex eucommiae water extract, angelica root water extract or the Mulberry fruit water extract of drying regime is stated to be less than
5%, the percentage is that water accounts for the Radix Rehmanniae water extract, folium cortex eucommiae water extract, angelica root water extract or Mulberry fruit water extract
The percentage of quality.
In the present invention, the Radix Rehmanniae can be the dry of scrophulariaceae rehmannia glutinosa plant Rehmannia glutinosa Libosch
Dry root tuber.
In the present invention, the Radix Rehmanniae can by the way that autumn is excavated, except the new Radix Rehmanniae of removing LU, fibrous root and silt, delay
It is slow to bake to eighty per cant drying.
In the present invention, the preferred Radix Rehmanniae xanthorrhiza of Radix Rehmanniae.
In the present invention, the folium cortex eucommiae can be the dried leaf of Eucommiaceae plant Cortex Eucommiae Eucommia ulmoides Oliv..
The folium cortex eucommiae can be dried by harvesting in 5 to October folium cortex eucommiae through water-removing.
In the present invention, the angelica root can be that this product is umbelliferae angelica Angelica sinensis (Oliv.)
The dry root of Diels.The angelica root can remove the angelica root of fibrous root and silt, wait for that moisture slightly evaporates by excavating autumn end
Afterwards, it is bundled into wisp, upper canopy, slowly smoke-dried beancurd is made with pyrotechnics.
In the present invention, the Mulberry fruit can be the drying fruit ear of moraceae plants mulberry Morous alba L..The Mulberry fruit
The Mulberry fruit harvested when can be by the way that fruit in 4~June reddens, is dried, or is dried after slightly steaming obtained.
In the present invention, " the Radix Rehmanniae water extract ", " folium cortex eucommiae water extract ", " angelica root water extract " or " Mulberry fruit water
Water extract in extract " can be the product obtained according to conventional water extraction in this field, the preferred following methods of the present invention：20
~100 DEG C, raw material is extracted in water；The raw material is Radix Rehmanniae, folium cortex eucommiae, angelica root or Mulberry fruit；It is described
When raw material is Radix Rehmanniae, extraction obtains the Radix Rehmanniae water extract；When the raw material is folium cortex eucommiae, extraction obtains the folium cortex eucommiae
Water extract；When the raw material is angelica root, extraction obtains the angelica root water extract；When the raw material is Mulberry fruit, extract
To the Mulberry fruit water extract.
When described " extracting in water ", the raw material can be extracted in water respectively, or by two or more
The raw material extracts in water simultaneously.
In a better embodiment of the invention, the raw material is through pulverization process.
In the present invention one more preferably in embodiment, grain size of the raw material after pulverization process is 10~40 mesh, such as 10
~20 mesh.
In an of the invention better embodiment, the temperature of the extraction is 75 DEG C~95 DEG C, such as 80 DEG C~90 DEG C.
In a better embodiment of the invention, the number extracted in the water is 2 times.
In a better embodiment of the invention, when being extracted in the water, the weight ratio of water and the raw material is 8:1~
12:1。
Preferably, the raw material is stirred extraction in water.
In the present invention, the water extract can also pass through post-processing.After the post-processing may include filtering, concentration and drying
One or more processing modes.
Wherein, described to filter the customary filtration methods that this field can be used, for example, by using strainer filtering and/or ceramic membrane mistake
The method of filter.In a better embodiment of the invention, the water extract is first through strainer filtering, and the filtrate being obtained by filtration is again through pottery
Porcelain membrane filtration.
The specification of the strainer can be the mesh of 100 mesh~200.
The ceramic membrane can be tubular ceramic membrane or Multichannel ceramic membrane.
The ceramic membrane can be selected from alumina ceramic membrane, zirconia ceramics film, titanium oxide ceramics film and silicon oxide ceramics film
In one or more, such as zirconia ceramics film.
The membrane aperture of the ceramic membrane can be 0.8~1 μm, such as 1 μm.
Wherein, described to concentrate the Conventional concentration method that this field can be used, such as reduced vacuum concentration and/or the concentration of RO films
Method.In a better embodiment of the invention, first carries out the concentration of RO films and carry out reduced vacuum concentration again.
The RO films can be PA membrane, then such as PA membrane DOW FILMTEC BW30LE-400.
The membrane aperture of the RO films can be 0.1~1nm, such as 0.1nm.
When being concentrated using RO films, thickening temperature can be 20 DEG C~45 DEG C；When using reduced vacuum concentration, concentration
Temperature can be 50~70 DEG C.
The pressure of the reduced vacuum concentration can be -0.054~-0.089MPa.
The concentration time can be judged from the angle for saving energy consumption, such as be sentenced according to the Brix values after concentration
It is disconnected, such as in the preparation process of the Radix Rehmanniae water extract, the Brix after concentration is 20-40%；
In the preparation process of the folium cortex eucommiae water extract, the Brix after concentration is 15-30%；
In the preparation process of the angelica root water extract, the Brix after concentration is 20-30%；
In the preparation process of the Mulberry fruit water extract, the Brix after concentration is 10-20%.
Wherein, the conventional drying methods of this field can be used in the drying, such as are spray-dried.
Include following components in a preferred embodiment of the present invention mode, in the Chinese medicine composition：Radix Rehmanniae water extract
55 parts, 15 parts of folium cortex eucommiae water extract, 15 parts of 15 parts of angelica root water extract and Mulberry fruit water extract；The Radix Rehmanniae water extract, institute
It is defined as described above to state folium cortex eucommiae water extract, the angelica root water extract or the Mulberry fruit water extract.
Include following components in a better embodiment of the invention, in the Chinese medicine composition：Radix Rehmanniae water extract 15
Part, 5 parts of folium cortex eucommiae water extract, 70 parts of 5 parts of angelica root water extract, 5 parts of Mulberry fruit water extract and prebiotics；The Radix Rehmanniae water carries
Object, the folium cortex eucommiae water extract, the angelica root water extract, the Mulberry fruit water extract or prebiotics institute as defined above
It states.
Include following components in a better embodiment of the invention, in the Chinese medicine composition：Radix Rehmanniae water extract 30
Part, 10 parts of folium cortex eucommiae water extract, 40 parts of 10 parts of angelica root water extract, 10 parts of Mulberry fruit water extract and prebiotics；The Radix Rehmanniae
Water extract, the folium cortex eucommiae water extract, the angelica root water extract, the Mulberry fruit water extract or the prebiotics definition such as
It is preceding described.
Include following components in a better embodiment of the invention, in the Chinese medicine composition：Radix Rehmanniae water extract 35
Part, 15 parts of folium cortex eucommiae water extract, 25 parts of 10 parts of angelica root water extract, 15 parts of Mulberry fruit water extract and prebiotics；The Radix Rehmanniae
Water extract, the folium cortex eucommiae water extract, the angelica root water extract, the Mulberry fruit water extract or the prebiotics definition such as
It is preceding described.
In the present invention, the Chinese medicine composition can be composed of the following components：15 parts~55 parts of Radix Rehmanniae water extract, folium cortex eucommiae
5 parts~25 parts of water extract, 5 parts~25 parts of angelica root water extract, 5 parts~25 parts of Mulberry fruit water extract, 0~70 part of prebiotics, institute
It is 100 parts to state the sum of Chinese medicine composition each component；The Radix Rehmanniae water extract, folium cortex eucommiae water extract, angelica root water extract or mulberry
Sorosis water extract is defined as described above.
The present invention also provides a kind of preparation methods of the Chinese medicine composition, are selected from following either method：
Method one：It comprises the steps of：By 15 parts~55 parts of Radix Rehmanniae water extract, 5 parts~25 parts of folium cortex eucommiae water extract, when
Return 5 parts~25 parts of root water extract, 5 parts~25 parts of Mulberry fruit water extract to be mixed, obtains the Chinese medicine composition；It is described
Radix Rehmanniae water extract, folium cortex eucommiae water extract, Radix Angelicae Sinensis water extract or Mulberry fruit water extract are defined as described above；
Or method two：It comprises the steps of：At 20~100 DEG C, raw material is extracted in water, is obtained containing glutinous rehmannia
15 parts~55 parts of root water extract, 5 parts~25 parts of folium cortex eucommiae water extract, 5 parts~25 parts of angelica root water extract, Mulberry fruit water extract 5
Part~25 parts of the Chinese medicine composition, you can；The raw material is Radix Rehmanniae, folium cortex eucommiae, angelica root and Mulberry fruit；It is described to carry
Take, the Radix Rehmanniae water extract, folium cortex eucommiae water extract, Radix Angelicae Sinensis water extract or Mulberry fruit water extract it is defined as described above.
It is described to mix the conventional mixing method that can refer to this field in the method one.
The present invention also provides a kind of Chinese medicine compositions in preparing prevention and/or treatment constipation drug or food
Using.
The present invention also provides a kind of Chinese medicine compositions to prepare the application in improving intestinal flora drug or food.
The present invention also provides a kind of Chinese medicinal composition preparations, and it includes in prevention and/or treatment effective dose
Drug composition and pharmaceutical carrier；The preparation is tablet, granule or oral preparation.
In the present invention, the pharmaceutical carrier refers to the pharmaceutical carrier of pharmaceutical field routine, is to solve the molding of preparation
Property, validity, stability, safety conventional pharmaceutical carrier in addition to the active ingredient (s in prescription is added, such as diluent (such as carboxylic first
Sodium starch etc.), adhesive (such as povidone), disintegrant (such as microcrystalline cellulose), lubricant (such as magnesium stearate, micro mist silicon
Glue etc.) and other adjuvants.
In the present invention, " prevention and/or the treatment effective dose " indicates that (i) prevents and/or treat herein described
Disease specific or illness Chinese medicine composition of the present invention amount, (ii) weaken, improve or eliminate specific disease described herein
Disease or illness one or more symptoms Chinese medicine composition of the present invention amount, or (iii) prevent or delay it is described herein
The amount of the Chinese medicine composition of the present invention of the breaking-out of one or more symptoms of disease specific or illness.
Without prejudice to the field on the basis of common sense, above-mentioned each optimum condition can be combined arbitrarily each preferably to get the present invention
Example.
The reagents and materials used in the present invention are commercially available.
The positive effect of the present invention is that：
The present invention is herbaceous material by preferred Radix Rehmanniae, folium cortex eucommiae, angelica root and Mulberry fruit, carries out water and carries, and can
Reasonable compatibility prebiotics, reasonable price is safe and non-toxic, and mouthfeel is excellent, relaxes bowel, and can adjust intestinal flora.
Specific implementation mode
It is further illustrated the present invention below by the mode of embodiment, but does not therefore limit the present invention to the reality
It applies among a range.In the following examples, the experimental methods for specific conditions are not specified, according to conventional methods and conditions, or according to quotient
Product specification selects.
Embodiment 1：Different temperatures radix rehmanniae recen extracts stachyose yield comparative test
Radix Rehmanniae xanthorrhiza raw material (being purchased from Hebei Kang Pai prepared slices of Chinese crude drugs factory, lot number 181126-W) crushes 10~40 mesh, weighs 6 parts
20g Radix Rehmanniae xanthorrhiza powder, is separately added into 400g pure water, a room temperature ultrasonic extraction 90min, remaining 5 parts in 40 DEG C, 60 DEG C, 80
DEG C, 100 DEG C of stirring in water bath extract 90min, take extracting solution, HPLC-MS method (high performance liquid chromatographs：Agilent 1290；Inspection
Survey device：Mass spectrum Agilent6430；Chromatographic column：Agilent H-Plex H Na(10μm,7.7×300mm)；Efficient liquid phase item
Part：Mobile phase uses ultra-pure water；Flow velocity：0.2mL/min；85 DEG C of column temperature；Mass Spectrometry Conditions：Nebulizer pressure 40psi, capillary electricity
Press (holotype 4000)) content of stachyose in Detection and Extraction liquid, calculate stachyose extract yield.Experimental result is as follows：
Table 1：Under different temperatures, content of stachyose and recovery rate in radix rehmanniae recen extracting solution
| Extracting temperature | Content of stachyose in extracting solution | Extract yield |
| Room temperature (ultrasound) | 36.84 | 100% |
| 40℃ | 24.72 | 67.1% |
| 60℃ | 28.86 | 78.3% |
| 80℃ | 33.48 | 90.9% |
| 100℃ | 26.78 | 72.7% |
If experiment shows that radix rehmanniae recen does not use ultrasonic method, 80 DEG C or so of Extracting temperature more suitable.Therefore when large-scale production,
Extracting temperature preferably uses 80 ± 5 DEG C.
Embodiment 2：Plant extracts hybrid combination prepares sample A
Radix Rehmanniae xanthorrhiza raw material (being purchased from Hebei Kang Pai prepared slices of Chinese crude drugs factory, lot number 161126-W) crushes (10~40 mesh), 80 ± 5
Twice, first time ratio of water to material (water weight/raw material weight) is 12 to the extraction of DEG C hot water, stirs extraction time 60min；Second of water material
Than 8, extraction time 30min, extracting solution filters (200 mesh of strainer), after merging filtration extracting solution, ceramic membrane (Hefei wind and cloud film point
From Technology Co., Ltd., 0.1 μm of zirconia ceramics film) secondary filter, filtrate is through RO films (PA membrane DOW FILMTEC
BW30LE-400,0.1nm) it is concentrated at 20~45 DEG C, then depressurized (- 0.089MPa) at 50 DEG C and be concentrated in vacuo to properly
Concentration (Brix (ATAGO PAL-1)：20-40%), after UHT sterilizings, Direct spraying is dry that radix rehmanniae recen water extract, water content are small
In 5% (test method refers to the first methods of GB 5009.3-2016), (15-55% containing stachyose, content of stachyose assay method are same
Test method in embodiment 1), yield is 45 ± 10%.
Cortex Eucommiae leaf raw material (driving product agricultural, lot number 20160901 purchased from Cili, Hunan) crushes (10-20 mesh), 90 ± 5 DEG C of heat
Water extracts twice, and first time ratio of water to material (weight/raw material weight of water) is 12, stirs extraction time 60min；Second of ratio of water to material
8, extraction time 30min, extracting solution strainer (100 mesh) filtering, after merging filtration extracting solution, ceramic membrane (Hefei wind and cloud UF membrane
Technology Co., Ltd., 0.1 μm of zirconia ceramics film) secondary filter, filtrate is through RO films (PA membrane DOW FILMTEC
BW30LE-400 it) is concentrated at 25~40 DEG C, then is depressurized (- 0.081MPa) at 60 DEG C and be concentrated in vacuo to suitable concentration
(Brix：15-30%), UHT sterilizing after, Direct spraying it is dry folium cortex eucommiae water extract (2-12% containing chlorogenic acid content；Water extract
Water content is less than 5%, (test method refers to the first methods of GB 5009.3-2016).Wherein, the determination of chlorogenic acid method
For：High performance liquid chromatograph：Agilent 1290：Detector：DAD, chromatographic column：Agilent Eclipse Plus C18(5μm,
4.6×250mm)；Mobile phase：A acetonitriles, 0.1% aqueous formic acids of B carry out gradient elution, 0min, 5%A；1min, 5%A；
12min, 30%A；16min, 95%A；17min, 95%A；18min, 5%A；Flow velocity：0.3mL/min；Detection wavelength is
320nm；30 DEG C of column temperature), yield is 25 ± 5%.
Angelica root raw material is purchased from Hebei Shen Hao prepared slices of Chinese crude drugs factory, and lot number 20160131 is crushed to 10-20 mesh, 90 ± 5 DEG C of heat
Water extracts twice, and first time ratio of water to material (weight/raw material weight of water) is 12, stirs extraction time 60min；Second of ratio of water to material
8, extraction time 30min, extracting solution strainer (200 mesh) filtering, after merging filtration extracting solution, ceramic membrane (Hefei wind and cloud UF membrane
Technology Co., Ltd., 0.1 μm of zirconia ceramics film) secondary filter, filtrate is through RO films (PA membrane DOW FILMTEC
BW30LE-400), concentrated at 25~40 DEG C, then depressurized (- 0.076MPa) at 65 DEG C and be concentrated in vacuo to suitable concentration
(Brix：20-30%), appropriate (the 15~30% of material quantity) maltodextrin is added, after UHT sterilizings, Direct spraying drying is proper
It is 35 ± 5% to return root water extract, net yield.Radix Angelicae Sinensis water extract water content is less than 5%, and (test method refers to GB 5009.3-2016
First method).
Mulberry fruit raw material (be purchased from Hebei Shen Hao prepared slices of Chinese crude drugs factory, lot number 160202-W) is crushed to 10-20 mesh, 85 ± 5 DEG C
Hot water extracts twice, and first time ratio of water to material (weight/raw material weight of water) is 12, stirs extraction time 60min；Second of water material
Than 8, extraction time 30min, extracting solution strainer (200 mesh) filtering, after merging filtration extracting solution, ceramic membrane (Hefei wind and cloud film point
From Technology Co., Ltd., 0.1 μm of zirconia ceramics film) secondary filter, filtrate is through RO films (PA membrane DOW FILMTEC
BW30LE-400), concentrated at 25~40 DEG C, then depressurized (- 0.070MPa) at 70 DEG C and be concentrated in vacuo to suitable concentration
(Brix：10-20%), add appropriate maltodextrin (the 40~60% of material quantity), after UHT sterilizings, Direct spraying it is dry mulberry
Sorosis water extract, net yield are 50 ± 5%.Mulberry fruit water extract water content is less than 5%, and (test method refers to GB 5009.3-
2016 first methods).
The 4 sections of water extracts prepared by above method, 55 parts of Radix Rehmanniae xanthorrhiza water extract, 15 parts of folium cortex eucommiae water extract, Radix Angelicae Sinensis
15 parts of root water extract, 15 parts of Mulberry fruit water extract are sufficiently mixed uniformly, according to this field conventional formulation technique, be made tablet form,
Bead dosage form or oral liquid formulation food.
Embodiment 3：Low cost vegetable plant water extract compatibility oligofructose prepares sample B
The 4 kinds of water extracts prepared in embodiment 2,15 parts of Radix Rehmanniae xanthorrhiza water extract, 10 parts of folium cortex eucommiae water extract, angelica root water
10 parts of extract, 10 parts of Mulberry fruit water extract, 55 parts of compatibility oligofructose are uniformly mixed, according to this field conventional formulation technique, system
Dosage form, bead dosage form or oral liquid formulation food in blocks.
Embodiment 4：Low cost vegetable plant water extract compatibility inulin prepares sample C
The 4 kinds of water extracts prepared in embodiment 2,25 parts of Radix Rehmanniae xanthorrhiza water extract, 15 parts of folium cortex eucommiae water extract, angelica root water
15 parts of extract, 15 parts of Mulberry fruit water extract, 30 parts of compatibility inulin are uniformly mixed, according to this field conventional formulation technique, piece are made
Dosage form, bead dosage form or oral liquid formulation food.
Embodiment 5：Plant extracts compatibility xylo-oligosaccharide prepares sample D
The 4 kinds of water extracts prepared in embodiment 2,35 parts of radix rehmanniae recen water extract, 15 parts of folium cortex eucommiae water extract, Radix Angelicae Sinensis water extract
10 parts, 15 parts of Mulberry fruit water extract, 25 parts of compatibility xylo-oligosaccharide are uniformly mixed, according to this field conventional formulation technique, piece are made
Dosage form, bead dosage form or oral liquid formulation food.
Embodiment 6：Plant extracts compatibility galactooligosaccharide prepares sample E
The 4 kinds of water extracts prepared in embodiment 2,30 parts of radix rehmanniae recen water extract, 25 parts of folium cortex eucommiae water extract, Radix Angelicae Sinensis water extract
15 parts, 5 parts of Mulberry fruit water extract, 25 parts of compatibility galactooligosaccharide are uniformly mixed, according to this field conventional formulation technique, are made
Tablet form, bead dosage form or oral liquid formulation food.
Embodiment 7：Plant extracts compatibility oligoisomaltose prepares sample F
The 4 kinds of water extracts prepared in embodiment 2,30 parts of radix rehmanniae recen water extract, 15 parts of folium cortex eucommiae water extract, Radix Angelicae Sinensis water extract
25 parts, 5 parts of Mulberry fruit water extract, 25 parts of compatibility oligoisomaltose are uniformly mixed, according to this field conventional formulation technique, system
Dosage form, bead dosage form or oral liquid formulation food in blocks.
Embodiment 8：The oligomeric gossypose of plant extracts compatibility prepares sample G
The 4 kinds of water extracts prepared in embodiment 2,25 parts of radix rehmanniae recen water extract, 15 parts of folium cortex eucommiae water extract, Radix Angelicae Sinensis water extract
10 parts, 25 parts of Mulberry fruit water extract, 25 parts of the oligomeric gossypose of compatibility are uniformly mixed, according to this field conventional formulation technique, are made
Tablet form, bead dosage form or oral liquid formulation food.
Comparative example 1：Plant extracts compatibility oligoisomaltose prepares sample H
The 3 kinds of water extracts prepared in embodiment 2,15 parts of folium cortex eucommiae water extract, 15 parts of angelica root water extract, Mulberry fruit water carry
15 parts of object, 55 parts of compatibility oligoisomaltose are uniformly mixed, according to this field conventional formulation technique, tablet form, granule are made
Type or oral liquid formulation food.
Effect example
Effect example 1：Sample A-H effect of relaxing bowel is tested
It is promulgated according to the Ministry of Public Health《Health food is examined and assessment technique specification》Required standard method in (2003 editions), exhibition
Open the animal confirmatory experiment of effect of relaxing bowel.
The cleaning grade Kunming kind male white mouse 260 for selecting Shanghai Slac Experimental Animal Co., Ltd. to provide.
Mouse feed is provided by the double lion experimental animal feed technology Services Co., Ltd in Suzhou.
120 mouse are chosen, 10 groups is randomly divided into, every group 12, carries out intestinal motility experiment；Other 120, it is randomly divided into 10
Group, carries out defecation time, fecal grains and stool weight determination experiment by every group 12.
Above-mentioned sample A-H is administered, dosage are arranged with 30 times of daily intaking amount of being grown up in dosage, gavage mouse,
Continuous feeding 7d.If Normal group and diphenoxylate Constipation Model control group.
Table 2：Each given the test agent is promoted to mouse small intestine prepared Chinese ink and the influence of defecation experiment
| Test group | Ink progradation P/% | The first just time/point | 6h fecal grains | 6h stool weights/mg |
| Normal group | 60.9±7.6* | 116.2±3.4* | 26.7±2.2* | 275.5±20.2* |
| Model control group | 28.1±5.3 | 138.0±8.9 | 12.2±0.8 | 131.4±9.2 |
| Sample A | 42.9±5.1* | 120.6±6.4* | 19.8±2.4* | 214.6±18.7* |
| Sample B | 53.9±6.2* | 118.8±5.8* | 18.9±2.7* | 205.4±22.3* |
| Sample C | 55.8±6.5* | 117.6±4.9* | 19.6±1.9* | 210.8±20.6* |
| Sample D | 54.6±5.8* | 120.4±6.2* | 20.6±2.2* | 224.6±22.8* |
| Sample E | 52.3±5.6* | 121.3±5.4* | 20.4±2.0* | 222.4±20.8* |
| Sample F | 53.6±5.2* | 122.4±6.0* | 20.2±2.5* | 221.3±18.8* |
| Sample G | 50.8±4.8* | 118.4±6.4* | 20.8±2.1* | 228.6±21.6* |
| Sample H | 38.1±4.8 | 130.2±7.3 | 17.6±1.0 | 170.4±8.2 |
* P is indicated<0.01, significant difference；
Test result shows compared to model control group, in addition to given the test agent H groups, remaining A-G group mouse ink progradation
It obviously increases, and significant difference.6h defecations grain number and weight, it is more than model control group, show compatibility product of the present invention
With significant effect of relaxing bowel.
Effect example 2：Sample A-H adjusts intestinal flora animal efficacy test
It is promulgated according to the Ministry of Public Health《Health food is examined and assessment technique specification》Required standard method in (2003 editions), exhibition
Open the animal confirmatory experiment of effect of relaxing bowel.
The cleaning grade Kunming kind male white mouse 120 for selecting Shanghai Slac Experimental Animal Co., Ltd. to provide.
Mouse feed is provided by the double lion experimental animal feed technology Services Co., Ltd in Suzhou.
108 mouse are chosen, 9 groups is randomly divided into, every group 12, the experiment of intestinal flora functional movement is adjusted；It will be upper
It states sample A-H to be administered, dosage is that dosage, gavage mouse, continuous feeding is arranged with 30 times of daily intaking amount of being grown up
14d.If negative control group (gives distilled water).
Table 3：Influence (lgCFU/g) of each given the test agent to mouse intestinal flora immunoregulation function
* P is indicated<0.01, significant difference；After test result shows feeding 14d, compared to negative control group, except by
Test agent H groups are outer, remaining each given the test agent A-G group, and beneficial bacterium animal bifidobacteria in stool in mice, Lactobacillus animalis obviously increases
Add, and harmful bacteria animal C.perfringens quantity is basically unchanged, and obviously has the function of to adjust intestinal flora to mouse.
Claims (10)
1. a kind of Chinese medicine composition, which is characterized in that include following components：15 parts~55 parts of Radix Rehmanniae water extract, folium cortex eucommiae water
5 parts~25 parts of 5 parts~25 parts of extract, 5 parts~25 parts of angelica root water extract and Mulberry fruit water extract.
2. Chinese medicine composition as described in claim 1, which is characterized in that the content of stachyose is in the Radix Rehmanniae water extract
15%~55%, such as 15%~50%；Percentage is the mass percent that stachyose takes up an area xanthorrhiza water extract gross mass；
And/or the content of the chlorogenic acid in the folium cortex eucommiae water extract is 3%~10%, such as 2%~12%；Percentage is
Chlorogenic acid accounts for the mass percent of folium cortex eucommiae water extract gross mass；
And/or the content of the Radix Rehmanniae water extract is 15 parts~45 parts；Such as 30 parts~35 parts；
And/or the content of the folium cortex eucommiae water extract is 5 parts~15 parts；Such as 5 parts~10 parts；
And/or the content of the angelica root water extract is 5 parts~15 parts；Such as 5 parts~10 parts；
And/or the content of the Mulberry fruit water extract is 5 parts~15 parts；Such as 5 parts~10 parts；
And/or the dried root that the Radix Rehmanniae is scrophulariaceae rehmannia glutinosa plant Rehmannia glutinosa Libosch；
And/or the dried leaf that the folium cortex eucommiae is Eucommiaceae plant Cortex Eucommiae Eucommia ulmoides Oliv.；
And/or the angelica root is the drying that this product is umbelliferae angelica Angelica sinensis (Oliv.) Diels
Root；
And/or the drying fruit ear that the Mulberry fruit is moraceae plants mulberry Morous alba L.；
And/or also comprising probiotics in the Chinese medicine composition.
3. Chinese medicine composition as claimed in claim 2, which is characterized in that the prebiotics content is 0 part~70 parts, but is not
0；Such as 25 parts~50 parts；Such as 25 parts~40 parts again；
And/or the prebiotics are oligosaccharides prebiotics；For example, the oligosaccharides prebiotics are selected from stachyose, oligomeric fruit
It is one or more in sugar, xylo-oligosaccharide, galactooligosaccharide, oligoisomaltose, gossypose and inulin.
4. Chinese medicine composition as described in claim 1, which is characterized in that its is composed of the following components：Radix Rehmanniae water extract 15
Part~55 parts, 5 parts~25 parts of folium cortex eucommiae water extract, 5 parts~25 parts of angelica root water extract, 5 parts~25 parts of Mulberry fruit water extract, benefit
Raw 0~70 part of member, the sum of described Chinese medicine composition each component are 100 parts；The Radix Rehmanniae water extract, folium cortex eucommiae water extract, when
Return the definition of root water extract, Mulberry fruit water extract or prebiotics as described in any one of claim 1-3.
5. Chinese medicine composition as described in claim 1, which is characterized in that " the Radix Rehmanniae water extract ", " folium cortex eucommiae water carries
Water extract in object ", " angelica root water extract " or " Mulberry fruit water extract " is prepared by the following method to obtain, including following step
Suddenly：At 20~100 DEG C, raw material is extracted in water；The raw material is Radix Rehmanniae, folium cortex eucommiae, angelica root or mulberry fruit
Fruit；When the raw material is Radix Rehmanniae, extraction obtains the Radix Rehmanniae water extract；When the raw material is folium cortex eucommiae, extraction obtains institute
State folium cortex eucommiae water extract；When the raw material is angelica root, extraction obtains the angelica root water extract；The raw material is Mulberry fruit
When, extraction obtains the Mulberry fruit water extract.
6. Chinese medicine composition as claimed in claim 5, which is characterized in that, can will be described when described " extracting in water "
Raw material extracts in water respectively, or two or more described raw materials are extracted in water simultaneously；
And/or the raw material is through pulverization process, grain size of the raw material after pulverization process is 10~40 mesh, then such as 10~
20 mesh；
And/or the temperature of the extraction is 75 DEG C~95 DEG C, such as 80 DEG C~90 DEG C；
And/or the number extracted in the water is 2 times；
And/or when being extracted in the water, the weight ratio of water and the raw material is 8:1~12:1, such as extraction water and institute for the first time
The weight ratio for stating raw material is 12:1, it is 8 that second, which is extracted water and the weight ratio of the raw material,:1；
And/or the raw material is stirred extraction in water；
And/or the water extract is also by post-processing；The post-processing is comprising one or more after filtering, concentration and drying
Processing mode.
7. Chinese medicine composition as claimed in claim 6, which is characterized in that use strainer filtering and/or ceramics when the filtering
The method of membrane filtration；The method that the concentration is concentrated using reduced vacuum concentration and/or RO films；Preferably, the ceramic membrane choosing
It is one or more in self-alumina ceramic membrane, zirconia ceramics film, titanium oxide ceramics film and silicon oxide ceramics film；The RO films
For PA membrane.
8. the preparation method of Chinese medicine composition as described in claim 1, which is characterized in that it is selected from following either method：
Method one：It comprises the steps of：By 15 parts~55 parts of Radix Rehmanniae water extract, 5 parts~25 parts of folium cortex eucommiae water extract, angelica root
5 parts~25 parts of water extract, 5 parts~25 parts of Mulberry fruit water extract are mixed, and the Chinese medicine composition is obtained；The glutinous rehmannia
Root water extract, folium cortex eucommiae water extract, Radix Angelicae Sinensis water extract or Mulberry fruit water extract any one of definition such as claim 1-5 in institute
It states；
Or method two：It comprises the steps of：At 20~100 DEG C, raw material is extracted in water, is obtained containing Radix Rehmanniae water
5 parts of 15 parts~55 parts of extract, 5 parts~25 parts of folium cortex eucommiae water extract, 5 parts~25 parts of angelica root water extract and Mulberry fruit water extract~
25 parts of the Chinese medicine composition, you can；The raw material is Radix Rehmanniae, folium cortex eucommiae, angelica root and Mulberry fruit；The extraction, institute
State Radix Rehmanniae water extract, folium cortex eucommiae water extract, Radix Angelicae Sinensis water extract or Mulberry fruit water extract definition such as claim 1-5 in it is any
Described in.
9. if claim 1~7 any one of them Chinese medicine composition is in preparing prevention and/or treatment constipation drug or food
Application；Or preparing the application in improving intestinal flora drug or food.
10. a kind of Chinese medicinal composition preparation, it includes prevention and/or any one of the claims 1~7 for the treatment of effective dose
In Chinese medicine composition and pharmaceutical carrier；The preparation is tablet, granule or oral preparation.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110893193A (en) * | 2019-06-27 | 2020-03-20 | 内蒙古伊利实业集团股份有限公司 | Novel application of bifidobacterium lactis BL-99 |
| CN113171408A (en) * | 2021-03-25 | 2021-07-27 | 哈尔滨百世普康生物科技有限公司 | Composition for relaxing bowels or regulating intestinal flora, preparation method, application and preparation thereof |
| CN113750134A (en) * | 2020-06-01 | 2021-12-07 | 深圳市领治医学科技有限公司 | Traditional Chinese medicine microecological preparation for patients with ischemic stroke |
-
2018
- 2018-04-26 CN CN201810385989.0A patent/CN108498626A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110893193A (en) * | 2019-06-27 | 2020-03-20 | 内蒙古伊利实业集团股份有限公司 | Novel application of bifidobacterium lactis BL-99 |
| CN110893193B (en) * | 2019-06-27 | 2023-03-24 | 内蒙古伊利实业集团股份有限公司 | Novel application of bifidobacterium lactis BL-99 |
| CN113750134A (en) * | 2020-06-01 | 2021-12-07 | 深圳市领治医学科技有限公司 | Traditional Chinese medicine microecological preparation for patients with ischemic stroke |
| CN113171408A (en) * | 2021-03-25 | 2021-07-27 | 哈尔滨百世普康生物科技有限公司 | Composition for relaxing bowels or regulating intestinal flora, preparation method, application and preparation thereof |
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Application publication date: 20180907 |