CN108498538A - A kind of calcium polysulfide soluble powder and its application - Google Patents
A kind of calcium polysulfide soluble powder and its application Download PDFInfo
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- CN108498538A CN108498538A CN201810496856.0A CN201810496856A CN108498538A CN 108498538 A CN108498538 A CN 108498538A CN 201810496856 A CN201810496856 A CN 201810496856A CN 108498538 A CN108498538 A CN 108498538A
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- calcium polysulfide
- soluble powder
- calcium
- drug
- sticker
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
Abstract
The invention discloses a kind of calcium polysulfide soluble powder and its applications.Calcium polysulfide is added wetting agent, bleeding agent, sticker and carrier and makes soluble powder by the present invention, it can not only penetrate hair and touch skin, and can adhere to drug on skin and hair, and drug residual effect is stronger.The present invention is milk cow, milch goat and birds using object.Main function is all kinds of acarids killed in livestock and poultry body surface and environment, such as itch mite, itch mite, thorn mite etc..The present invention can be used without the off-drug period with lactation period, without abandoning milk, to person poultry harmless, belong to environmental type product.
Description
Technical field
The invention belongs to field of veterinary, in particular to a kind of external application insecticide of veterinary drug.
Background technology
Acarid belongs to Arthropoda, Arachnoidea, and the small animal of a kind of build of Acari, body size is generally all
At 0.5 millimeter or so, some small to 0.1 millimeter, most of types are less than 1 millimeter.In the world it has been found that acarid has more than 50000
Kind, many types are related with medicine.The healthy relationship of discovered in recent years acarid and people are very close, such as gamasid, itch mite, scabies
Mite, compacted mite, flour mite, dust mite and Pu mite etc..The acarid often sent out on livestock and poultry has the itch mite of pig, the itch mite of cattle and sheep, the peronium of birds
Mite (thorn mite) etc..Acarid is very big to the harm of livestock and poultry, and the inflammatory reaction of skin, itch is mainly caused to be oozed out, and incrustation is fallen
The symptoms such as hair, seriously affect the production performance of livestock and poultry, also result in the death of livestock and poultry sometimes.
The drug for being presently used for controlling and killing livestock and poultry acarid mainly has：Organophosphorus insecticides, pyrethroid kill
Worm agent and Amitraz, ivermectin class etc..It is all fine that organic phosphates drug and Amitraz kill acarid effect, but this two
Class drug withdrawal is used in milk cow in lactation period or milch goat.Although ivermectin class is driven, mite effect is also fine, it can be with
Milk is metabolized, and remains in milk very high, and the U.S. and European Union have forbidden using it for lactation cattle and sheep.Fenvalerate toxicity is relatively low,
It can be used for the acarid prevention of birds, but chrysanthemum esters medicine easily generates drug resistance.Milk cow or milch goat in lactation period, once
Acarid is infected, can only discarding milk or goat milk using the above drug, (basudin abandons the milk phase 72 hours, and it is small that Amitraz abandons the milk phase 48
When, ivermectin abandons the milk phase 20).So prodigious economic loss is caused to farm or raiser.In addition the above
Pharmaceutical manufacturing process is all more complicated, and seriously polluted, expensive.
Finding a kind of milk cow and the except mite drug of milch goat lactation period of can be used for becomes the emphasis studied instantly.Lime sulfur is
Drive mite drug of the currently the only approval in the U.S. for milk cow in lactation period and milch goat, no off-drug period, without abandoning milk.Early stage stone sulphur closes
Agent adds water to boil, method is more complicated, time-consuming and laborious, and can only for livestock and poultry prevention acarid disease using quick lime and sulphur
It is current now to endure, it cannot preserve.Japan is the country for developing calcium polysulfide crystal earliest, and China has also followed by synthesized more sulphur
Change calcium crystal.This technology changes obtained the present situation of lime sulfur by tanning in the past.Currently, calcium polysulfide crystal is all to use
Make pesticide, the diseases and cotton red spider etc. such as prevention crops, the powdery mildew of fruit tree, rust are also never developed to
Veterinary drug.
Invention content
In view of the above-mentioned problems, wetting agent, bleeding agent, sticker and carrier, which is added, in calcium polysulfide by the present invention makes solubility
Powder, for killing the acarid in milk cow, milch goat and livestock and poultry body surface and breeding environment, it can not only penetrate hair and touch skin
Skin, and drug can be adhered on skin and hair, drug residual effect is stronger.The calcium polysulfide soluble powder of the present invention is used
In food animal noresidue, belong to environmental type product.In addition, compared with existing acaricide, calcium polysulfide is not present
The problem of drug resistance, and it is free from environmental pollution, it is cheap.
The technical scheme is that：A kind of calcium polysulfide soluble powder, characterized in that its component and weight ratio are：It is more
Calcium sulfide 0.1%-90%, wetting agent 0.1%-5%, bleeding agent 0.1-5%, sticker 0.1-5%, carrier surplus.
The sulfur content of above-mentioned raw materials calcium polysulfide (crystal) is 40%-46%.Sulphur in calcium polysulfide accounts for total solubility
The content of powder is 0.1-40%.
Above-mentioned wetting agent is that the one or both in neopelex and Triton X-100 arbitrarily compares
Example combination.
Above-mentioned bleeding agent is sldium lauryl sulfate.
Above-mentioned sticker is the one or both arbitrary proportion combination in gelatin and polyvinyl alcohol.
Above-mentioned carrier is the one or both arbitrary proportion combination in sodium sulphate or ammonium sulfate.
Optimum ratio：Calcium polysulfide 10%-90%, wetting agent 1%-5%, bleeding agent 1-5%, sticker 0.1-1% are carried
Body surplus.
More preferably proportioning：Calcium polysulfide 10%-90%, neopelex 1%-5%, sldium lauryl sulfate 1-
5%, gelatin 0.1-1%, anhydrous sodium sulfate surplus.
The present invention is compounded with calcium polysulfide, wetting agent, bleeding agent, sticker and carrier, and wherein calcium polysulfide is as effective
Ingredient, no off-drug period, without abandoning milk.Wetting agent is added in calcium polysulfide soluble powder of the present invention, drug can be made in milk cow, milk
The body surface moistening of sheep and birds etc. and expansion；Then bleeding agent and sticker are further used, hair can be not only penetrated and connect
It contacts skin, and drug can be adhered on skin and hair, drug residual effect is stronger, therefore miticidal effect is better than common
Amitraz solution and basudin solution.
The present invention also provides above-mentioned calcium polysulfide soluble powders in the body surface acarid for killing milk cow, milch goat and birds
Application in terms of (itch mite, itch mite, thorn mite etc.).
Application method：Calcium polysulfide soluble powder is dissolved in the solution that water is made into 0.5-2%, is sprayed on milk cow, milch goat and fowl
The body surface of class, or be sprayed on the bedding and padding in poultry house；It can be spaced after 7 days again that medication is primary according to mite effect is driven.Main function
It is all kinds of acarids killed in livestock and poultry body surface and environment, such as itch mite, itch mite, thorn mite etc..
The beneficial effects of the invention are as follows：The present invention is for controlling and killing milk cow, milch goat and birds body surface and breeding environment
In acarid, no off-drug period, without abandoning milk.To person poultry harmless, belong to environmental type product.The present invention is using bleeding agent and glues
Agent, hair can be not only penetrated and touch skin, and drug can be adhered on skin and hair, drug residual effect is more
By force, therefore miticidal effect is better than common Amitraz solution and basudin solution.
Specific implementation mode
The specific implementation mode of the present invention is described in further detail below.Following calcium polysulfide soluble powders contain
Amount each means that the sulphur in calcium polysulfide accounts for the content of total soluble powder.
Embodiment 1
Formula：It is calcium polysulfide (sulfur content 45%) 89kg, neopelex 2kg, sldium lauryl sulfate 2kg, bright
Glue 1kg, anhydrous sodium sulfate 6kg.
Preparation method：It stocks up according to the above formula.It puts into flat mixer, mixes 30 minutes to get content more than 40%
Calcium sulfide soluble powder.
Above-mentioned calcium polysulfide soluble powder quality standard and inspection result are as follows：
1. character：Yellow or yellow greenish powder；
2. checking
2.1 appearance uniform degree：It takes test sample appropriate, is placed in glossy paper, tile about 5cm2, its surface is flattened, bright
Place's observation, answers uniform color, no decorative pattern and color spot.
2.2 loss on drying：According to《Republic of China Veterinary Pharmacopoeia》One annex 0831 of version in 2015 measures, at 105 DEG C
To constant weight, less loss weight must not cross 10.0% for drying.
2.3 dissolubility：It takes test sample appropriate, sets in nessler colorimetric tube, adding water that the solution of 50ml is made, (a concentration of clinic makes
2 times of used time high dose concentration), it is spun upside down 10 times at 25 DEG C ± 2 DEG C, test sample should all dissolve, and stand 30 minutes, must not
There is muddy or precipitation to generate.
2.4 acid-base value：Take this product 0.2g, add water 20ml, be ultrasonically treated, make uniformly, according to《People's Republic of China's veterinary drug
Allusion quotation》One annex 0631 of version in 2015 measures, and pH value should be 10.0-12.0.
3. assay
In the beaker of known weight, about 2g samples (claiming accurate to 0.0002g) are weighed rapidly, is dissolved in water, is transferred to
In 250mL volumetric flasks, it is diluted to scale with not carbonated water, is shaken up.Accurate 50.00mL sample solutions of drawing are in pre-
First fill 10mL zinc chloride ammonia spirit (50g zinc chloride are dissolved in 500mL water, add 125mL ammonia spirits and 50g ammonium chlorides,
It is diluted with water to 1000mL.) and the conical flask of 25.00mL10% sodium sulfite solutions in, heated at least in boiling water bath
45min, it is primary every 10min shakings, it is used in combination wash bottle to wash inner wall.Reaction finishes, and 30mL10% strontium chloride solutions are added while hot,
After shaking up, 5min is stood, is transferred in 250mL volumetric flasks.It is cooling, it is diluted with water to scale, is shaken up.It is filtered with quantitative filter paper,
Notice that the initial part of filtrate should discard, collects clear filtrate.
It is accurate to draw 50.00mL filtrates in 250mL Erlenmeyer flasks, 10mL formaldehyde is added, shakes up.The instruction of 3mL starch is added
Liquid is dropped to iodine standard solution (0.1mol/L) and blue just occurs, and as terminal, volume are denoted as V1。
Another accurate absorption 50.00mL sample solutions, are placed in and are placed with the 250 of 10mL zinc chloride ammonia spirit and 20mL water in advance
In mL triangular flasks, 45min or more is heated in boiling water bath, it is cooling, it is diluted with water to scale, is shaken up.It is filtered, is noted with quantitative filter paper
The initial part of meaning filtrate should discard, and collect clear filtrate.
It is accurate to draw 50.00mL filtrates in 250mL Erlenmeyer flasks, add two drop methyl reds, is adjusted with tartaric acid solution to being in
Subacidity.3ml starch indicator solutions are added, is dropped to iodine standard solution and blue just occurs, as terminal, volume are denoted as V2。
The mass fraction x (%) of lime sulfur, is calculated as follows：
In formula：
V1--- sample titration consumption iodine standard solution volume, mL；
V2--- the volume of correction titration consumption iodine standard solution, mL；
C --- iodine standard solution concentration, mol/L；
M --- sample mass, g；
0.03207 --- with 1.00mL iodine standard solutions (c (1/2I2)=1.000mol/L) comparable sulphur quality, g；
1.750 --- conversion calcium polysulfide coefficient is (with CaSS3Meter).
4. survey report
1 calcium polysulfide soluble powder survey report of table
As can be seen from Table 1：The character of calcium polysulfide soluble powder, appearance uniform degree, loss on drying, dissolubility, soda acid
Degree and content's index meet the requirements.
Test example：Calcium polysulfide soluble powder kills milk cow, milch goat body surface acarid effect test
1. materials and methods
1.1 material
Drug：12.5% veterinary drug limited liability company of Amitraz solution western Shandong produces, lot number 20170105；60% 2
Veterinary drug limited liability company of Qin Nong solution western Shandong produces, lot number 20170621；Calcium polysulfide soluble powder embodiment 1 carries
For.
Equipment：Magnifying glass, light microscope, sprayer, blade, culture dish；
Experimental animal：The milk cow 400 of acarid is infected, milch goat 400 is in milk production phase (selection criteria：Microscopy is true
Recognizing cattle and sheep body surface has acarid live body, and shows pruritis).
1.2 test method
A groups：Milk cow 100, milch goat 100,12.5% Amitraz solution do 500 times of dilutions, spray delivery, with handle with water
Subject to fur squirts, medication is primary again after 7 days at interval；
B groups：Milk cow 100, milch goat 100,60% basudin solution do 1000 times of dilutions, spray delivery, with handle with water
Subject to fur squirts, medication is primary again after 7 days at interval；
C groups：Milk cow 100, milch goat 100, calcium polysulfide soluble powder are dissolved in water and are made into 2% solution, spray delivery, with
Subject to fur is squirted, medication is primary again after 7 days at interval, then is spaced 7 days spray third times；
D groups：Milk cow 100, milch goat 100, with water spray, is subject to and fur is squirted, and interval is sprayed primary again after 7 days.
1.3 criterion：It is disappeared with clinical symptoms, decrustation grows virgin wool, and microscopy is standard without acarid live body.
2 test results
Test result is as shown in table 2.
2 each group of table kills acarid effect test result
Amitraz test group (A groups) after first time medication as can be seen from Table 1, basudin test group (B groups) milk cow and milk
The negative conversion rate of goat is above the negative conversion rate of calcium polysulfide test group (C groups) milk cow and milch goat.Reason may be：Amitraz and
Basudin is all the drug being more toxic, and can quickly knock down acarid, and drug effect plays relatively fast.
Amitraz test group (A groups) after secondary medication, basudin test group (B groups) milk cow negative conversion rate is 100%, milk mountain
The negative conversion rate of sheep is respectively 96% and 95%.The negative conversion rate of calcium polysulfide test group (C groups) milk cow and milch goat is 100%.
Reason may be that the hair of milch goat is thicker, and Amitraz and the more difficult hair that penetrates of basudin aqueous solution touch skin.And this
Bleeding agent and sticker are added in invention calcium sulfide soluble powder, hair can be not only penetrated and touch skin, and can be with
Drug is adhered on skin and hair, drug residual effect is stronger, therefore miticidal effect is molten better than Amitraz solution and basudin
Liquid.
Although calcium polysulfide is relatively slow in drug effect speed relative to Amitraz and basudin, final miticidal effect is wanted
Better than Amitraz and basudin.
3. conclusion
From experiment it can be seen that calcium polysulfide soluble powder of the present invention miticidal effect and common acaricide Amitraz and
Basudin compares, and effect is the same on milk cow, but the animal miticidal effect thicker for hair is better than Amitraz and diazine
Agriculture is a kind of good miticide.
Embodiment 2
Formula：Calcium polysulfide (sulfur content 45%) 44.5kg, neopelex 2kg, sldium lauryl sulfate 2kg,
Gelatin 1kg, anhydrous sodium sulfate 50.5kg.
Preparation method：It stocks up, is put into flat mixer according to the above formula, mix 30 minutes to get content more than 20%
Calcium sulfide soluble powder.
Embodiment 3
Formula：Calcium polysulfide (sulfur content 45%) 29.7kg, neopelex 1.5kg, sldium lauryl sulfate
2.0kg, gelatin 0.6kg, anhydrous sodium sulfate supply 100kg.
Preparation method：It stocks up, is put into flat mixer according to the above formula, mix 30 minutes to get content more than 15%
Calcium sulfide soluble powder.
Embodiment 4
Formula：Calcium polysulfide (sulfur content 45%) 59.3kg, Triton X-100 2.5kg, sldium lauryl sulfate
2.5kg, polyvinyl alcohol gelatin 0.8kg, anhydrous slufuric acid ammonium supply 100kg.
Preparation method：It stocks up, is put into flat mixer according to the above formula, mix 30 minutes to get content 30%
Calcium polysulfide soluble powder.
Claims (10)
1. a kind of calcium polysulfide soluble powder, characterized in that its component and weight ratio are：Calcium polysulfide 0.1%-90%, wetting
Agent 0.1%-5%, bleeding agent 0.1-5%, sticker 0.1-5%, carrier surplus.
2. a kind of calcium polysulfide soluble powder as described in claim 1, characterized in that the sulfur content of the raw material calcium polysulfide
For 40%-46%, the content that the sulphur in calcium polysulfide accounts for total soluble powder is 0.1-40%.
3. a kind of calcium polysulfide soluble powder as claimed in claim 2, characterized in that its component and weight ratio are：More vulcanizations
Calcium 10%-90%, wetting agent 1%-5%, bleeding agent 1-5%, sticker 0.1-1%, carrier surplus.
4. a kind of calcium polysulfide soluble powder as described in any one of claim 1-3, characterized in that the wetting agent is
The arbitrary proportion of one or both in neopelex and Triton X-100 combines.
5. a kind of calcium polysulfide soluble powder as described in any one of claim 1-3, characterized in that the bleeding agent is
Sldium lauryl sulfate.
6. a kind of calcium polysulfide soluble powder as described in any one of claim 1-3, characterized in that the sticker is
One or both arbitrary proportion combination in gelatin and polyvinyl alcohol.
7. a kind of calcium polysulfide soluble powder as described in any one of claim 1-3, characterized in that the carrier is sulphur
One or both arbitrary proportion combination in sour sodium or ammonium sulfate.
8. a kind of calcium polysulfide soluble powder as claimed in claim 3, characterized in that its component and weight ratio are：More vulcanizations
Calcium 10%-90%, neopelex 1%-5%, sldium lauryl sulfate 1-5%, gelatin 0.1-1%, anhydrous sodium sulfate
Surplus.
9. claim 1-3, a kind of calcium polysulfide soluble powder described in any one of 8 are killing milk cow, milch goat and fowl
Application in terms of the acarid of class body surface.
10. the application method of claim 1-3, a kind of calcium polysulfide soluble powder described in any one of 8, characterized in that
Calcium polysulfide soluble powder is dissolved in the solution that water is made into 0.5-2wt%, is sprayed on the body surface of milk cow, milch goat and birds, or spray
On bedding and padding in poultry house.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201810496856.0A CN108498538B (en) | 2018-05-22 | 2018-05-22 | Calcium polysulfide soluble powder and application thereof |
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|---|---|---|---|
| CN201810496856.0A CN108498538B (en) | 2018-05-22 | 2018-05-22 | Calcium polysulfide soluble powder and application thereof |
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| CN108498538B CN108498538B (en) | 2020-09-01 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112618401A (en) * | 2021-01-15 | 2021-04-09 | 刘长德 | Shampoo special for pets and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001022814A1 (en) * | 1999-09-30 | 2001-04-05 | Monsanto Technology Llc | Package-mix agricultural chemical compositions having improved stability |
| CN105794840A (en) * | 2014-12-30 | 2016-07-27 | 王德堂 | Soluble granule for preventing and treating disease and insect damage to Radix Astragali |
-
2018
- 2018-05-22 CN CN201810496856.0A patent/CN108498538B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001022814A1 (en) * | 1999-09-30 | 2001-04-05 | Monsanto Technology Llc | Package-mix agricultural chemical compositions having improved stability |
| CN105794840A (en) * | 2014-12-30 | 2016-07-27 | 王德堂 | Soluble granule for preventing and treating disease and insect damage to Radix Astragali |
Non-Patent Citations (2)
| Title |
|---|
| 沈阳农学院主编: "《蔬菜昆虫学》", 30 April 1990, 农业出版社 * |
| 饶旭文: "石硫合剂治疗畜禽疥螨病药效试验", 《湖北农业科学》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112618401A (en) * | 2021-01-15 | 2021-04-09 | 刘长德 | Shampoo special for pets and preparation method thereof |
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Application publication date: 20180907 Assignee: SHANDONG LUXI ANIMAL MEDICINE SHARE Co.,Ltd. Assignor: Liu Changde|Liu Kai Contract record no.: X2021980009740 Denomination of invention: A soluble calcium polysulfide powder and its application Granted publication date: 20200901 License type: Common License Record date: 20210923 |
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