CN108495663A - Blood filtration component, device and method - Google Patents
Blood filtration component, device and method Download PDFInfo
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- CN108495663A CN108495663A CN201680077422.6A CN201680077422A CN108495663A CN 108495663 A CN108495663 A CN 108495663A CN 201680077422 A CN201680077422 A CN 201680077422A CN 108495663 A CN108495663 A CN 108495663A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3627—Degassing devices; Buffer reservoirs; Drip chambers; Blood filters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/02—Blood transfusion apparatus
- A61M1/0281—Apparatus for treatment of blood or blood constituents prior to transfusion, e.g. washing, filtering or thawing
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- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- External Artificial Organs (AREA)
- Prostheses (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
Abstract
A kind of equipment includes：Hollow body；Entrance, the entrance are fluidly connected to the hollow body；Piston, the piston are slidably engaged in the hollow body；And filter module, the filter module are arranged between the entrance and piston in the hollow body.During the distal piston translation from first position to the second position, the piston and hollow body collaboratively generate negative pressure relative to environment in the hollow body, will be in the fluid extraction of such as blood to the hollow body from there through the filter module.During the piston translation from the second position to the first position, the piston and hollow body collaboratively generate positive pressure relative to environment in the hollow body, so that filtered fluid is flowed out from the hollow body.The filter medium that the filter module may include filter housing, be placed in the shell, and be configured to seal the valve body of the opening distal face of the filter housing.
Description
Cross reference to related applications
This application claims entitled " blood filtration component, the device and method (Blood that submit on January 8th, 2016
Filtering Component, Apparatus, and Method) " U.S. Provisional Application No.62/276,817 and 2016
Year submit within 8 days 2 months it is entitled " blood filtration component, device and method (Blood Filtering Component,
Apparatus, and Method) " U. S. application No.15/018,880 priority, each in the application is with it
The mode being cited in full text is incorporated herein.
Technical field
The disclosure relates generally to the field of medical treatment device, and more particularly, to for filtering blood or other fluids
Component, device and method.
Background technology
Autotransfusion is that the blood of patient itself is discharged from body as needed during medical procedure, is then fed back
To the process of patient's body.In developing country, due to can be used the quantity of donated blood few and of high cost, usually using self defeated
Blood technology.These autotransfusions usually manually execute.Currently, manual autotransfusion is related to from open wound or collects in surface
Collect blood；Manually remove big clot；By pad of cotion filtering blood to remove smaller clot and biological particle；And it will
Filtered blood is introduced into storage bag, and before patient needs blood, blood is mixed with anti-freezing liquid in the storage bag
And it is stored.This process is very laborious, takes material and takes, and is usually directed to the coordination of three or more professionals.This
Outside, this process can encounter sterility problems.Therefore, improved transfusion set and method are global needs.
Invention content
The disclosure provides filtering blood and the new and useful component of other fluids, devices, systems, and methods.It is specific next
It says, each embodiment provided herein provides component, devices, systems, and methods for executing manual autotransfusion.It carries herein
The each embodiment supplied overcomes one or more in the shortcomings that previous manual auto transfusion apparatus and technology.
An aspect of this disclosure is related to a kind of detachable filter module for haemofiltration apparatus.Filter module
Including filter housing, the filter housing is formed by one or more side walls and close with partially or completely opening
Side and distal face.Filter module further comprises：The filter medium being placed in filter housing, and it is located at filter
Valve body in the distal end of shell.Valve body moves between opening configuration and closed configuration.In the closed configuration, main
Body valve seals the distal face of filter housing.When forming negative pressure in haemofiltration apparatus, valve body can be opened, and work as
When pressure returns to environmental pressure or positive pressure, valve body can be closed.
In some embodiments, filter module can be sized and be configured to be fixedly fitted to blood mistake
It filters in equipment, and liquid-tight seal is formed with the inner wall of haemofiltration apparatus.This filter module can also include from filtering
One or more side walls sealing surfaces outstanding of device shell, the sealing surfaces are configured to be pressed against haemofiltration apparatus
Inner wall.Filter housing and sealing surfaces can be whole (monolithic)；Alternatively, filter housing, sealing surfaces and
Valve body respectively can be individually formed and be attached during manufacturing process.
In some embodiments, filter medium can be pleated.Filter housing can be cylindrical.Valve body can be by
Fin (flap) formation.Filter housing can be transparent.
Another aspect of the present disclosure is related to a kind of filter module.Filter module includes：By what is folded with circular pattern
The filter medium that the grid (pleated mesh) that is pleated is formed；The elastic housing being disposed at least partially in around filter medium；With
And it is configured to mechanically seal the mechanical body valve of filter module.
In some embodiments, pleating grid can form gore, and filter medium can be located at around inner prop
Circle in.The grid that is pleated can have multiple holes, the multiple hole to be sized logical to prevent hemostasis block and big biological particle
The hole is crossed, while haemocyte being allowed to pass through hole.When by negative pressure, mechanical body valve can be opened to allow fluid to flow through
Filter medium, and be closed in environmental pressure or direct draught.Mechanical body valve can be formed by fin, and the fin applies in external pressure
It is closed when on to filter module, and when pressure in filter module increases opens.
Another aspect of the present disclosure is related to a kind of haemofiltration apparatus.Haemofiltration apparatus includes the stream for having fluid passage
Any embodiment of body absorption plant and filter module above or described elsewhere herein.In various embodiments,
Filter module can be located in the access of fluid absorbent means.
Description of the drawings
Fig. 1 illustrates the side view of one embodiment of haemofiltration apparatus.
Fig. 2 illustrates the side view of one embodiment of haemofiltration apparatus.
Fig. 3 A to 3B illustrate one embodiment of the haemofiltration apparatus moved between dummy status and full state respectively
Side view.
Fig. 4 illustrates the side view of one embodiment of haemofiltration apparatus.
Fig. 5 A to 5B illustrate the one embodiment for moving through the haemofiltration apparatus of induction stroke and compression stroke respectively
Side view.
Fig. 6 illustrates the side view of one embodiment of haemofiltration apparatus.
Fig. 7 illustrates the side view of one embodiment of haemofiltration apparatus.
Fig. 8 A to 8C illustrate one embodiment of the filter module in each embodiment for haemofiltration apparatus
Perspective view.
Fig. 9 A to 9B illustrate to form one embodiment of the filter housing of a part for the filter module of Fig. 8 A to 8C
Perspective view.
Figure 10 A to 10B illustrate an implementation of the valve body fin to form a part for the filter module of Fig. 8 A to 8C
The perspective view of example.
Figure 11 illustrates to form the perspective view of one embodiment of the inner prop of a part for the filter module of Fig. 8 A to 8C.
Figure 12 illustrates to form the perspective view of one embodiment of the filter of a part for the filter module of Fig. 8 A to 8C.
The exploded view of the filter module embodiment of Figure 13 definition graphs 8A to 8C.
Figure 14 A illustrate the perspective view of one embodiment of the filter module for the valve body for having in an open position.
Figure 14 B illustrate the perspective view of the filter module embodiment of Figure 14 A for the valve body for having in the close position.
Figure 15 illustrates the side of one embodiment of the haemofiltration apparatus formed by fluid absorbent means and filter module
View.
Specific implementation mode
The attached drawing and being described below for certain embodiments of the present invention provided is not intended to limit the invention to this
A little embodiments, but provided to enable those skilled in the art to obtain and use the present invention.
Component for filtering fluid, device and method are disclosed herein；In some embodiments provided herein, component,
Device and method are configured for the filtering blood during autotransfusion process.
As shown in fig. 1, in some embodiments, the equipment 100 for filtering blood or other fluids includes：Hollow master
Body 200；It is fluidly connected to the entrance 300 of hollow body 200；The piston 400 being slidably positioned in hollow body 200；
And the filter module 500 between entrance 300 and piston 400.In the illustrated embodiment, entrance 300 is in close
Side end and piston 400 is at the distal end of equipment 100.
Equipment 100 is preferably used for filtering, storage and/or conveying blood.For example, equipment 100 can be used for transfusing blood, wherein
Equipment is for filtering the blood extracted from patient or from collection vessel (such as, bowl or ground).Equipment is preferably from blood
Except clot and capable of in addition filtering carrys out the extraneous particles of autoblood.Equipment is preferably passive and is manually grasped by user
Make, but can be alternatively active and be driven by electronic system.
For example, as seen in Figure 2, equipment 100 can also comprise valve body 220, the valve body controls entrance 300
Fluid flowing between hollow body 200.As described in greater detail below, in some embodiments, valve body forms filtering
A part for device module 500.In such embodiments, valve body is identified as valve body 520.
Additionally or alternatively, equipment 100 may include outlet 240, and the outlet allows filtered fluid from hollow body
200 outflows, without passing back through contaminated filter.
Additionally or alternatively, equipment 100 may include the liquid storage device for fluidly connecting entrance 300 and hollow body 200
320.In some such embodiments, liquid storage device 320 is between entrance 300 and filter module 500.In other embodiments
In, filter module 500 can be located in liquid storage device 320.
Additionally or alternatively, equipment 100 may include entrance bindiny mechanism 340, and the entrance bindiny mechanism is by entrance 300
It is detachably connected to hollow body 200；In some embodiments, entrance bindiny mechanism 340 is by entrance 300 and liquid storage device 320
The two is connected to hollow body 200.
As shown in Figure 3A and 3B, equipment 100 is preferably configured to move induction stroke 30 in distal side by piston 400
And nearside movement compression stroke 40 in movement dummy status (A referring to Fig. 3) with expire state (B referring to Fig. 3) between convertibly
It is mobile.During induction stroke 30, piston head 420 (that is, proximal extremity of piston 400) is from being relatively close to the first of entrance 300
Position 10 moves distally to the second position 20 for being relatively distant from entrance 300.During induction stroke 30, piston 400 and hollow
Main body 200 collaboratively generates negative pressure relative to environment in hollow body 200.In other words, during piston 400 applies suction to
Inside empty main body, the suction draws fluid through entrance 300 and filter module 500 and enters in hollow body 200.
During compression stroke 40, piston head 420 is moved to first piston 10 from second piston 20.During compression stroke 40, piston 400
Positive pressure is collaboratively generated in hollow body 200 relative to environment with hollow body 200.In other words, piston 400 is by expulsion force
It is applied to inside hollow body, fluid is discharged from hollow body 200 for the expulsion force.Hollow body 200,420 and of piston head
Valve body 220/520 preferably collaboratively limits hollow body volume, and the hollow body volume passes through suction in the movement of piston 400
It expands when entering stroke 30 and is shunk when piston 400 is moved through compression stroke 40.Filtered fluid, is more preferably filtered
Blood afterwards preferably occupies hollow body volume after induction stroke 30.
Equipment 100 is preferably configured to minimize caking when blood is drawn into hollow body 200.Equipment is preferred
Ground minimizes caking at least partially by the velocity of blood flow of control access device.The equipment 100 of some embodiments allows
0.5L/min is to the velocity of blood flow between 1.6L/min.However, the equipment 100 of other embodiments promotes higher or lower blood stream
Speed.In one embodiment, equipment is by controlling peak suction (for example, transversal by controlling entrance 300 and hollow body 200
Face ratio) control velocity of blood flow.In one embodiment, equipment is configured so that peak suction does not surpass during the suction stroke
Cross 150mm Hg (being less than environmental pressure/atmospheric pressure).In another embodiment, velocity of blood flow is controlled by 300 shape of entrance.
In another embodiment, velocity of blood flow by control the movement of piston 400 by the speed of hollow body 200 (for example, by control by
Frictional force that piston head 420 applies to 200 wall of hollow body) it controls.However, can include control velocity of blood flow it is any its
Its appropriate device or method.
The piston 400 of equipment is used to generate the pressure change in hollow body 200.As shown in Figure 3B, some embodiments
Piston 400 include piston head 420, shaft 440 and handle 460, wherein handle 460 will preferably be applied by shaft 440
Power is transmitted to piston head 420.Piston head 420 preferably has and cross section substantially similar inside hollow body so that living
420 perimeter of chock plug and formation slidable sealing inside hollow body.The piston head 420 of some embodiments by flexible material (such as
Rubber) it is made, but in other embodiments, the piston head can be substantially gas-tight seal by being formed with hollow body inside
Any suitable material is made.The shaft 440 of some embodiments has cross-like cross-section.In other embodiments, shaft 440 is
Solid hopkinson bar, hollow stem or any other suitable form.The handle 460 of some embodiments is T-handle 460；In other embodiments
In, handle 460 can be knob, bridge or any other suitable handle 460.
In one embodiment of equipment 100, shaft 440 and handle 460 are detachably connected to piston head 420.This energy
So that filtered blood is stored in equipment, is stored for a long time without exiting into blood bag.When removal shaft
440 and when handle 460, the pressure balance between hollow body volume and surrounding air preferably keeps 420 position of piston head, but
The locking mechanism for keeping 420 position of piston head can be also comprised by being equipment 100.In one embodiment of equipment 100, piston
First 420 and shaft 440 it is threaded so that shaft 440 removes shaft 440 from piston head 420 around the rotation of its longitudinal axis.
In such embodiments, 200 inside of hollow body and 420 perimeter of piston head can also comprise complementary threads (for example, substantially
Close to the second position 20), central shaft rod 440 makes the rotation in hollow body 200 of piston head 420 around the rotation of its longitudinal axis
With 420 position of lock piston head.Preferably further rotating and separate shaft 440 and piston head 420 in the same direction.
In another embodiment, piston head 420 and shaft 440 include pin locking mechanism, wherein can press a part for shaft 440 with from
Piston head 420 discharges shaft 440.Any other suitable bindiny mechanism can be alternatively for connection piston head 420 and shaft
440。
The hollow body 200 of equipment 100 is used to collaboratively generate positive pressure and/or negative pressure with piston 400；The hollow body
It is also a housing for the fluid flowed into.Hollow body 200 can be additionally useful for keeping miscellaneous equipment component (for example, filter module
500) relative position.Hollow body 200 has the cross section of substantial constant preferably along its length, but described hollow
Main body can alternatively have variable cross section.Hollow body 200 preferably has circular cross section, but the hollow master
Body can alternatively have oval, rectangle, polygon or any other suitable cross section.In one embodiment of equipment,
Hollow body 200 is hollow cylinder.Hollow body 200 is preferably essentially rigidity, and preferably by bio-compatible
Material is made.Hollow body 200 can also comprise the coating on hollow body inside, and floating coat is preferably bio-compatible
Coating.In some embodiments, coating is anti-freezing coating.
Hollow body 200 can also comprise piston retaining elements, and the piston retaining elements are for preventing entire piston
It is removed from hollow body.Position of the piston retaining elements in hollow body can be additionally useful for limiting the second position 20.Piston
Holding element preferably along 200 length positioning of hollow body first position 10 distal side.Piston retaining elements preferably exist
Operable between holding pattern and release mode, in the holding pattern, piston head is maintained at hollow by piston retaining elements
In main body, in the release mode, piston retaining elements allow entire piston head to retract from hollow body (for example, to allow
Dismounting and sterilization).In a variant, equipment 100 includes one or more through-holes, and as the one of piston retaining elements
A or more corresponding pin, wherein pin extends through through-hole to prevent piston head from retracting across pin.Pin can removably connect
Through-hole is connected to allow equipment to dismantle.However, can be configured using any other suitable piston retaining elements.
Additionally or alternatively, hollow body 200 may include the piston retainer in 300 distal side of entrance, wherein piston stop
Part preferably limits the maximum distance that piston 400 may be located remotely from the traveling of entrance 300.
Hollow body 200 can include additionally or alternatively filter holding area, and the filter holding area includes
A series of grooves that filter module 500 is located therein.Filter holding area is preferably located in the nearside of hollow body 200
On, in liquid storage device 320, adjacent or close to liquid storage device 320, but the filter holding area can be alternatively positioned at it is any
In suitable position.
The entrance 300 of equipment 100 is for promoting blood to flow into hollow body 200.In addition entrance 300 can filter out greatly
Clot.In various embodiments, entrance 300 is operably connected to the proximal extremity of hollow body 200.Preferably, entrance
300 is concentric with hollow body 200, but the entrance can also be alternatively connected to any desired part of hollow body 200.
Entrance 300 is preferably the nozzle for limiting straight channels；However, nozzle can alternatively limit tapered channel, whirlpool channel or
Any other suitable channel.Nozzle preferably has flat tip, but can alternatively have angled tip, band spiral shell
The tip of line, the tip with barb or any other suitable tip.Alternatively, entrance 300 can be any other suitable fluid
Entrance.Entrance 300 can be otherwise configured to minimize caking during blood flows into.In an example of equipment 100, match
Ratio between posting port 300 and the cross-sectional area of hollow body 200 so that during the suction stroke, in hollow body 200
Peak suction be no more than 150 millimetress of mercury.Entrance 300 is preferably removably attachable to hollow body 200, for example, passing through
Entrance bindiny mechanism 340 is detachably connected.In other embodiments, entrance 300 is formed as whole piece with hollow body 200.
Entrance 300 can also comprise the feature being attached for component, for example, barb or screw thread.The component of entrance 300 can be attached to
Including needle, IV pipes, blood bag or any other suitable component.
For example, as shown in FIG. 4, entrance 300 can also comprise in the channel of entrance 300, or it is located at entrance
Inlet valve 302 between 300 and filter module 500.Inlet valve 302 preferably when hollow body volume is under negative pressure at
In open position, and when hollow body volume is under positive pressure and/or environmental pressure (for example, atmospheric pressure) in closure position
It sets.Inlet valve 302 is preferably passive check valve, but may instead be active valve, changeover valve or any other suitable
Valve.Example inlet valve 302 includes duckbill valve, switch valve, ball valve or any other suitable valve.
For example, as shown in FIG. 4, equipment can also comprise outlet 240, and the outlet is for making blood from hollow master
Body 200 flows out.Outlet 240 is preferably provided for the second fluid path of fluid outflow, and the second fluid path is different from
The path of fluid inflow/filtering flow.When positive pressure is applied to inside hollow body, outlet 240 is preferably in the compression stroke phase
Between allow fluid from hollow body 200 flow out.Length positioning of the outlet 240 preferably along hollow body 200.In some implementations
In example, outlet 240 is in first position 10 between filter module 500 and piston head 420；In other embodiments, go out
Mouth 240 is in the second position 20 between filter module 500 and piston head 420.Therefore, filtered fluid need not flow
Contaminated fluids are crossed to be flowed out from hollow body 200.Outlet 240 preferably includes blood bag, pipe or any other suitable defeated
The outlet barb or screw thread that liquid mechanism is connectable to.Ratio between outlet 240 and the transverse cross-sectional area of hollow body 200 is excellent
Selection of land is configured to maximum positive voltage being restricted to convenient pressure, for example, 150 millimetress of mercury.
Outlet 240 can also comprise the outlet valve 242 between outlet 240 and main body 200.Outlet valve 242 is preferably
Passive check valve, but can be alternatively active valve, changeover valve or any other suitable valve.Example outlet valve 242 wraps
Include duckbill valve, switch valve, ball valve or any other suitable valve.In one embodiment of equipment 100, such as institute in Fig. 5 A
Show, outlet valve 242 is preferably in when hollow body volume is under negative pressure and/or environmental pressure (for example, atmospheric pressure) and closes
Position is closed, and as shown in Figure 5 B, it is in an open position when hollow body volume is in direct draught.
In another embodiment of equipment, outlet valve 242 is in an open position when hollow body volume is under negative pressure,
It is in an open position when hollow body volume is in direct draught, and it is substantially equal to atmospheric pressure in hollow body volume pressure
When it is in the close position.In this embodiment, the blood bag containing anti-freezing liquid is connectable to outlet 240 before induction stroke.
When the movement of piston 400 passes through induction stroke, blood and anti-coagulants are drawn by entrance 300 and outlet 240 simultaneously respectively
In hollow body volume, wherein blood is mixed with anti-coagulants in hollow body volume.The translation that piston 400 passes through compression stroke
It then will be in the transfusion set (for example, blood bag) of anti-coagulants-blood mixture fluid push-in connection.In this embodiment, 240 energy are exported
Microfilter is enough also comprised, the microfilter is used to before flowing into hollow body volume filter from anti-freezing liquid micro-
Biology and/or particle；Microfilter is preferably removed in anti-freezing liquid before the outflow of hollow body 200.In some embodiments
In, by transfusion set (for example, blood bag) be connected to outlet 240 can will outlet 240 from remaining closed position during the suction stroke
It sets to be switched to and stays open position during the suction stroke.
Additionally or alternatively, equipment 100 can include a large amount of anti-freezing liquids for example, in hollow body 200, wherein flowing
After entering in hollow body volume, blood can be mixed with anti-freezing liquid.Anti-freezing liquid can include such as heparin or cumarin chemical combination
One or more thrombolytics of one or more antithrombotic agents of object, such as streptokinase or urokinase and/or one or more anti-molten
Suppository.Anti-coagulants in hollow body 200 is preferably less than realized when piston head 420 is in the second position 20 most big-and-middle
Empty main body volume.In some embodiments, anti-coagulants volume is less than the half of maximum hollow body volume.Alternatively, can include
Any suitable anti-freezing liquid volume, wherein being based preferably on the concentration of anti-freezing liquid to determine anti-coagulants volume.
For example, as shown in Fig. 5 A to Fig. 7, equipment can also comprise liquid storage device 320, and the liquid storage device is by entrance 300
It is connected to hollow body 200.Liquid storage device 320 is preferably essentially hollow and limits accumulator volume.Liquid storage device configures
It is preferably minimized clot to be formed, and preferably facilitates laminar flow and/or minimize between entrance 300 and hollow body 200
Turbulent flow.For example, in various embodiments, liquid storage device 320 provides seamlessly transitting between entrance 300 and hollow body 200.Liquid storage
Device 320 can be additionally provide for liquid and extravasated blood/Pei enter the region of equipment 100, and the region, which has, is used for liquid blood
Enough volumes of filter are detached and entered with solid grumeleuse.Liquid storage device 320 is subsequently used as that can not pass through the solidifying of filter
The storage region of block.The liquid storage device 320 of some embodiments (such as embodiment of Fig. 6) is not occupied by miscellaneous equipment component.Herein
In class embodiment, filter module 500 is located at 320 distal side of liquid storage device.The liquid storage of other embodiments (for example, embodiment of Fig. 7)
Device 320 is partially or completely occupied (for example, when filter module 500 is taper) by filter module 500.
In one embodiment of equipment 100, liquid storage device 320 is taper, and entrance 300 is located at taper liquid storage device 320
At tip, and hollow body 200 is connected to the pedestal of taper liquid storage device 320.Liquid storage device 320 can be parabolic cone, elliptic cone,
Frustum, cylinder or any other suitable shape, wherein entrance 300 are preferably located in liquid storage device apex, with liquid storage
Device central axis is concentric, but can be alternatively positioned in any other suitable position.Liquid storage device 320 and entrance 300 are preferred
Ground is fabricated to whole piece, but can alternatively be fabricated to individual piece.
For example, returning to Fig. 2, equipment can also comprise entrance bindiny mechanism 340, and the entrance bindiny mechanism is by entrance
300 are detachably connected to hollow body 200.It is highly preferred that entrance bindiny mechanism 340 is removable by liquid storage device 320 and entrance 302
It is connected to hollow body 200 with unloading.Entrance bindiny mechanism 340 preferably enables a device to removable between opening and closing configure
It is dynamic.In the open configuration, liquid storage device 320 is separated from hollow body 200 at least partly, enabling close to filter module
500.In some embodiments, when equipment 100, which is in, to be opened in configuration, filter module 500 can be removed from equipment.Entering
In the opening configuration of mouth bindiny mechanism 340, valve body 220/520 preferably seals hollow body volume to prevent from polluting.It is closing
It closes in configuration, 320 perimeter of liquid storage device preferably forms fluid-impermeable sealing with 200 perimeter of hollow body.Liquid storage device-is hollow
Main body engagement can also comprise o-ring or washer to promote more preferably Fluid Sealing.By allowing to open equipment 100, entrance
Bindiny mechanism 340 can allow for equipment to dismantle, this can aid in apparatus assembly sterilization (for example, autoclaving), filter
It replaces and equipment reuses.
In one embodiment of equipment, entrance bindiny mechanism 340 includes at least two complementary attachment mechanisms.Bindiny mechanism
Liquid storage device 320 can be surrounded and 200 perimeter of hollow body is evenly distributed.In another embodiment of equipment, entrance connects machine
Structure 340 includes bindiny mechanism and the hinge for being rotatably attached hollow body 200 and liquid storage device 320, wherein when engagement connection knot
When structure, bindiny mechanism and hinge collaboratively seal liquid storage device 320 relative to hollow body 200.Bindiny mechanism can include one
Or more clip, screw, adhesive, latch, clip, bayonet locking component, spring force mechanism (for example, in liquid storage device 320
With the rubber strip stretched between the hollow body 200 in 320 distal side of liquid storage device), complementary threads or any other suitable connection
Mechanism.
The filter module 500 of equipment 100 is for detaching clot with volumetric blood, and wherein blood is during the suction stroke
It is preferably extracted across filter module 500 before into hollow body volume.In some embodiments, filter module
500 are arranged in hollow body 200 and preferably cross over the entire cross section extension of hollow body 200.Filter module 500
It can alternatively be partially or entirely in liquid storage device 320.Filter module 500 can have any suitable shape.Some realities
The filter module 500 for applying example is cylindrical (for example, dish type), and wherein diameter is substantially equal to hollow body inside diameter.
In other embodiments, filter is taper；In one embodiment, conical filter is substantially filled with the volume of liquid storage device 320.
Preferably assembling filter device module 500 so that the filter module and hollow body 200 are concentric, but the filter mould
Block can be assembled in relative to hollow body 200 in any suitable position.The filter module 500 of some embodiments is connected to
Hollow body 200 (for example, in filter module slot).The filter module 500 of other embodiments is connected to liquid storage device 320
(for example, in filter module slot).In some embodiments that liquid storage device 320 is detachably attached to hollow body 200, storage
The removal of liquid device 320 also removes filter module 500 simultaneously.In other embodiments, the removal of liquid storage device 320 exposes filter
Module 500 is to be easily removed hollow body 200.
Filter module 500 preferably includes at least one porous filter.The hole size of filter is preferably sufficiently large
To allow haemocyte (for example, red blood cell) to pass through filter, and it is preferably sufficiently small to filter out grumeleuse.Hole size is preferably
No more than 170 μm (diameter), and in some embodiments, hole size is between 40 μm to 170 μm, but in other embodiments
In, hole is sized to alternatively greater or lesser.It is big can be based on application (for example, the species to originate from according to blood) selecting hole
It is small.The hole size of some embodiments is substantially uniform in entire filter, but in other embodiments, the hole size exists
Uniformly or non-uniformly change in entire filter.The filter of some embodiments has 50% porosity, but in other realities
It applies in example, filter can have any suitable porosity between 0% and 100%.Filter is preferably by biofacies
Capacity materials, for example, nylon or polyester fiber are made, but the filter can alternatively and/or in addition by cloth, paper, ceramics,
Coated polymeric, coating metal or any other suitable material are made.The filter of some embodiments is basically uniform
Whole piece.In other embodiments, filter from the multiple pleated filters radially of the central axis extended by being made.Filter is excellent
Selection of land is disk or block, but can be alternatively film.Filter module 500 can include having any appropriate bore size
Any suitable number of filter, wherein the filter with large hole size is preferably close to the filtering with smaller hole size
Device is arranged.In the equipment variations with multiple filters, filter is preferably adjacent (for example, contacting adjacent filter),
But it can be alternatively with adjacent filter interval to set a distance.
One embodiment of filter module 500 is shown in Fig. 8 A to Fig. 8 C.Illustrated filter module can be formed
A part for Autotransfusion device.For example, filter module 500 can form the equipment 100 described elsewhere herein
A part for any embodiment.In various embodiments, filter module 500 includes both filter and valve body, and mistake
Strainer modules are configured to filtering fluid and control fluid flow through filter.Such embodiment of filter module is by filter screen
540 (also known as filter mediums), filter housing 510 and the formation of valve body fin 520.Embodiment can also comprise inner prop
530.The example of some individual elements of filter module is shown in Fig. 9 A to Figure 12.Specifically, Fig. 9 A to Fig. 9 B are provided
One embodiment of filter housing 510, one embodiment of Figure 10 A to Figure 10 B provider's valves fin 520, Figure 11 are provided
One embodiment of inner prop 530, and Figure 12 provides one embodiment of filter screen 540.
In the filter module embodiment of Fig. 8 A to Fig. 8 C, filter screen 540 is placed in filter housing 510.Filtering
Device shell 510 is formed by side wall and with the proximal side and distal face partially or completely opened.In some embodiments, it filters
Device shell 510 is formed by cylindrical side wall.In some embodiments, filter housing includes on (one or more) side wall
One or more protrusions or other structures feature, for example, to promote the filter module and adjacent part of haemofiltration apparatus
Between Fluid Sealing.For example, as shown in Fig. 9 A to 9B, in some embodiments, filter housing 510 include side wall 512,
One or more outwardly extending raised 514 at first end, and one or more at second end inwardly prolong
The protrusion 516 stretched.In some embodiments, outwardly extending raised 514 are used as sealing surfaces, to compression filter module
The interior perimeter of 500 components (for example, hollow body 200 or liquid storage device 320) positioned, so as in filter module 500 and week
Formation seals between enclosing the interior perimeter of component.This sealing prevents fluid from bypassing filter medium.In some embodiments, it extends internally
Protrusion 516 be used as sealing surfaces, between filter housing 510 and valve body fin 520 formed sealing.Sealing surfaces
516 and valve body fin 520 form temporary sealing together across the surface of filter module 500, to prevent fluid in mistake
The upward out filter module in side.
In various embodiments, valve body fin 520 is positioned across the distal side of filter housing 510 or proximal side.One
In a little embodiments, valve body fin 520 and filter housing 510 are such as matched shown in Fig. 9 A to 10B including interlock feature
Close hole 518 and protrusion 522.Additionally or alternatively, adhesive can be used for valve body fin 520 being fixed to filter housing
510。
In some embodiments, valve body fin and/or one or more sealing surfaces are (for example, outwardly extending prominent
Play 514 and the protrusion that extends internally 516) with the one of (one or more) side wall of filter housing 510 512/entirety landform
At.In some embodiments, (one or more) sealing surfaces 514,516 and/or valve body fin 520 are individually formed simultaneously
And it could attach to filter housing.In some embodiments, the chemically or mechanically combination/bonding of valve body fin 520
(bond) part or sealing surfaces 516 of the side wall 512 of filter housing 510 are arrived.
The sealing surfaces of some embodiments are by thermoplastic elastomer (TPE), and such as, GLS Versaflex CL2242 are made.It is other
The sealing surfaces of embodiment are made of any number of common elastomer well known by persons skilled in the art.Exemplary materials include
But it is not limited to:Nitrile rubber (buna-N), ethylene propylene diene rubber (EPDM), fluorine silicone rubber, neoprene, polyurethane, silicon and fluorine
Rubber.As shown, for example, in Figure 14 A to Figure 14 B, in some embodiments, entire filter module 500, or in addition to mistake
Entire filter module 500 except strainer 540 is made of clear material to allow the visual inspection of clot.
By grid protocol, the grid is configured to remove not the filter 540 of each embodiment of filter module 500
It is suitble to any biological particle of autotransfusion.In illustrated embodiment, there are two layers of filter screens.First layer has gross porosity big
It is small, for example, its mesoporous is in 800 μm to 1mm of range.The second layer has pore size, for example, in 100 μm to 170 μm of model
In enclosing；This size allows haemocyte to pass through filter screen, while preventing larger component (such as, clot and bone particle pass through.At some
In embodiment, one layer of grid is provided, and in further embodiments, three layers or more layer grid are included in filter module
It is interior.In each embodiment of at least two filters of different sizes with hole, fine filtrator, which preferably has, is less than 170 μ
M, and the hole size more preferably between 40 μm and 170 μm.Coarse filter preferably has big more than the hole of fine filtrator
It is small, and preferably positioned closer to entrance 300 than fine filtrator, thus it is used as prefilter.By can in larger grumeleuse
Larger grumeleuse is removed before being engaged with the smaller hole of fine filtrator, coarse filter can be by preventing fine filtrator by larger grumeleuse
Block to increase the service life of initial filter.The coarse filter of some embodiments have no more than 170 μm hole size (for example,
80 μm, 100 μm, 150 μm etc.), but in other embodiments, coarse filter has larger hole size (for example, 200 μm, 600 μ
M, 0.1mm etc.).The coarse filter of some embodiments is abutted with fine filtrator, and the coarse filter can be alternatively far from thin mistake
Filter keeps a certain distance.In one embodiment, both coarse filter and fine filtrator have substantially the same diameter
Disk.In another embodiment, coarse filter is taper, and fine filtrator is substantially frustoconical, wherein coarse filter bottom
Seat tool has the diameter that the diameter with the relatively small footprint of fine filtrator is essentially equal, and the filter module 500 combined assembles
In the internal capacity of liquid storage device 320.
In one embodiment, filter module 500 is in the form of filter cylinder, during the filter cylinder may be removably coupled to
Empty main body 200 or liquid storage device 320.In some embodiments, hollow body 200 includes filter cylinder slot, and filter module 500 is configured
At being assemblied in the filter cylinder slot.Filter module 500 can be positioned in filter cylinder slot or be removed from filter cylinder slot.Filter module
500 and filter cylinder slot preferably therebetween formed sealing so that blood substantially flows through filter, and does not pass through filter mould
The perimeter of block 500 leaks.It is fully close to promote that equipment can also comprise the o-ring between filter module 500 and filter cylinder slot
Envelope.
During the assembling of some embodiments, filter screen 540 is placed or is formed in filter housing 510.In some realities
It applies in example, for example, in some embodiments with cylindrical filter module 500, filter screen 540 is pleated simultaneously with alternate folding
And it is wrapped in the circle around inner prop 530.The pleat of some embodiments forms gore.In some such embodiments, filtering
Each pleat of net 540 extends circle by the folding of the top and bottom (that is, proximal side and distal face) at or approximately at side wall 512
The entire height or most of height of cylindrical side wall 512.The side wall 512 and inner prop 530 of filter housing 510 make filter screen 540
Stablize it is in place in and contribute to filter screen to keep its shape.Inner prop 530 can be with the whole landform of filter housing 510
At or inner prop 530 fixedly can adhere to or be otherwise affixed to filter housing 510.In other embodiments, it filters
Device module 500 can be sized with shape to be assemblied in the non-cylindrical tubulose part of haemofiltration apparatus 100.Herein
In class embodiment, filter housing 510 can have different polygonal shapes, such as, but not limited to, rectangle.In such implementation
In example, the filter screen 540 of pleating can have matching or shape complementary in other ways.For example, in some embodiments, mistake
Filter shell 510 and pleating filter screen 540 are rectangles.In such embodiments, inner prop 530 can be not present.In each implementation
In example, filter screen 540 is directed so that the open surface of the open surface directed toward filter shell 510 of each fold is (that is, distal face
And proximal side).
Combined method can be used for filter screen 540 being fixed to filter housing 510.In some embodiments, Loctite
5240 UV solidification glues are used to filter being attached to shell.In other embodiments, other suitable biocompatible adhesives
(for example, UV solidifications, air-dried, vulcanization, two parts) are used alone or in combination.In addition, in some embodiments, filter housing
510 is overmolded to filter 540, thus by the embedded filter housing 510 of a part for filter screen 540 and/or inner prop 530
(if present) in.
Filter screen 540 is by being likely to reduced the material of damage to blood with blood compatibility and when blood passes through filter screen
It is made.In certain embodiments, filter screen 540 is pleated and is presented with circular shape, more to allow compared with flat disc
Flow passes through filter.This maximizes volume flow and reduces the stress on red blood cell to prevent cell rupture.If cell
On pressure rise above pressure 150mmHg, then the possibility damaged dramatically increases.Alternatively, filter screen 540 can be with other
Configuration (such as, flat, bending or conical by its shape) is presented.The shell 510 of some embodiments is made of elastomer to realize blood
Tight seal between filter plant 100 and filter module 500.The inner prop 530 of some embodiments by with filter housing 510
Identical or different elastomer is made.In other embodiments, inner prop 530 is not elastic.In some embodiments, filter
Both shell 510 and inner prop 530 (if present) are attached to filter screen 540 to prevent fluid from bypassing grid 540.
In some embodiments, one in the open surface of filter housing 510 is upper (that is, in proximal extremity or distal side
On end), valve body fin 520 covers entire surface and part is attached to filter housing 510.In a preferred embodiment, main
The distal face of 520 precoat filter shell 510 of body valve fin.As described above, valve body fin 520 can mechanically and/or change
It is attached to a part for filter housing 510 with learning.Fin 520 flexible is opened by being bent along junction so that the wing
The non-attachment part of piece 520 is displaced outwardly far from filter housing 510.It shows to open the example configured in Figure 14 A.Valve fin
520 opening allows blood to flow through filter screen 540 and to another chamber of haemofiltration apparatus 100 (for example, hollow body
200).When closing, such as shown in Figure 14 B, fin 520 leans against on filter housing 510 and crosses over filter housing 510
Entire surface extend, so as to sealing surface and prevent any reflux across filter 540.In various embodiments, when in mistake
When forming enough pressure in strainer modules 500 (for example, such as the piston 400 of haemofiltration apparatus 100 by upwards or to it is export-oriented far
Occur when being drawn away to side filter module 500), valve body fin 520 is opened.When under the pressure in filter module 500
(for example, the piston 400 when haemofiltration apparatus 100 is pushed away to nearside towards filter module 500 when falling below pressure threshold
When dynamic), valve body fin 520 is closed.The fin 520 of each embodiment is flexible material, and the flexible material is configured to most
The pressure needed for fin that smallization bending is opened and the forward traffic that realization passes through filter 540.
In the alternate embodiment of equipment 100, for example, as shown in Fig. 2, Fig. 4, Fig. 5 A and Fig. 5 B, fluid stream is controlled
The valve body entered in hollow body 200 is detached with filter module 500.In such embodiments, valve body 220 is preferably crossed over
The cross section of hollow body 200 extends so that valve body 220 can form basic upper fluid relative to the wall inside hollow body
Impermeable sealing.Valve body 220 is preferably located in hollow body 200, between filter module 500 and piston 400.One
As main body valve position preferably keep substantially fixed relative to filter module 500 by hollow body 200.For example, some
The valve body 220 of embodiment is placed in the groove being defined on the inner wall of hollow body 200.Valve body 220 is preferably nothing
Source check valve, but the valve body can be alternatively active valve (for example, electrically driven (operated)), two-way valve or any other conjunction
Suitable valve.The example of valve body 220 includes switch main body valve, duckbill valve, ball valve or any other suitable valve.
When negative pressure is applied to inside hollow body, the valve body 220/520 of each embodiment is preferably in induction stroke
Period is in an open position.When positive pressure is applied to inside hollow body, or when hollow body internal pressure is substantially equal to week
When the pressure in collarette border (for example, when piston 400 is static relative to hollow body 200), valve body 220/520 is preferably being pressed
It is in the close position during contracting stroke.By remaining closed position during compression stroke, as shown in Figure 5 B, valve body 220/
520 can promote the positive pressure in hollow body volume to generate, and thus promote blood via 240 outflow hollow body 200 of outlet.Or
Person, when positive pressure is applied to inside hollow body, valve body 220/520 can be in an open position during compression stroke,
Blood in middle hollow body 200 is flowed by entrance 300.In another embodiment of equipment 100, valve body 220/520 exists
It is moved between closed state and opening state during induction stroke, and is moved to closes from opening state during compression stroke
Conjunction state.Valve body 220/520 can alternatively have any other suitable configuration.
In some embodiments, the component of equipment 100 can be by that can be subjected to sterilization process, for example, thermal sterilization, radiation kill
The material of bacterium or chemical sterilization is made.Example sterilization process includes autoclaving, ultraviolet light irradiation or bleaching.In addition, equipment
Preferably by one or more biocompatible materials, more preferably bio-inert material is made component.Example materials include Topas
Cyclic olefin copolymer (TCOC),(Bayer Material Science company), makrolon, poly terephthalic acid second two
Ester (PET), polytetrafluoroethylene (PTFE) (PTFE), polyethylene, propylene glycol methyl ether acetate (PMA), bioavailable polymer, bio-compatible
Ceramics and biocompatible metal, for example, titanium, stainless steel.However, apparatus assembly can be made of any suitable material.Equipment
Component can also comprise coating.In a variant of equipment, coating can reduce blood clotting.In the another variant of equipment
In, coating is biocompatible coating；If apparatus assembly is made of biological incompatible material, this can be needed.Coating
Can include silicon, anti-coagulants coating (for example, EDTA, citrate, oxalates etc.) or any other suitable coating.Equipment group
Part preferably carries out injection molding, but can alternatively be sintered, marks or be manufactured using any other suitable method.
In alternative embodiments, above-mentioned filter module 500 can be with the haemofiltration apparatus of replacement (such as, Figure 15
Haemofiltration apparatus) it is used together.As illustrated in figure 15, haemofiltration apparatus can be by any fluid absorbent means 600
It being formed, the fluid absorbent means have fluid passage 610 and can form internal negative pressure in fluid passage 610, so as to
Fluid is promoted to absorb.For example, absorption plant 600 can be the eye dropper (that is, pasteur pipet) for having deformable roof.Or
Person, absorption plant 600 can be suction pipe, conduit or pipe.It in such embodiments, can be by the distal side of absorption plant end
It is manually sucked on end or by the way that distal end is connected to pump, vacuum, deformable sphere or other suitable devices come shape
At internal negative pressure.In these alternate embodiments, filter module 500 can be sized to be assemblied in fluid absorbent means
In 600 access 610.
In one embodiment of method, method includes providing a kind of haemofiltration apparatus.Haemofiltration apparatus can have
There is any or all of feature being described elsewhere herein.As a non-limiting example, equipment includes hollow body
200, liquid storage device 320 with the entrance 300 for being connected to 200 end of hollow body is slidably disposed in hollow body 200
Piston 400, and the filter module 500 in hollow body 200 between piston 400 and entrance 300.Filter module
500 include filter 540 and valve body 520.Hollow body 200 further comprises outlet 240 and outlet valve 242, and liquid storage
Device 320 further comprises inlet valve 302.Liquid storage device 320 and hollow body 200 can be by bayonet lock mechanisms or any other
Suitable bindiny mechanism is detachably connected.Piston 400 includes having the diameter substantially the same with the internal diameter of hollow body 200
Piston head 420, be connected to the shaft 440 of piston head 420, and be connected to the handle 460 of shaft 440.
Method further comprises mobile piston 400 by induction stroke, and wherein piston 400 is beaten by the movement of induction stroke
Inlet valve 302 and valve body 520 are opened, and fluid (for example, blood) is drawn by hollow body by entrance and filter 540
In 200.When flowing through filter 540, fluid and the undesirable separation of particles in fluid.For example, blood can enter it is hollow
In main body 200, and filter 540 prevents clot and big biological particle from passing through hollow body.Valve body 520 can be completed to inhale
Enter stroke to be closed later, to prevent fluid from flowing back across filter 540.Method can also comprise mobile piston 400 and pass through
Compression stroke, wherein piston 400 pass through the mobile opening outlet valve 242 of compression stroke and across 240 outflow fluids of outlet.
In some embodiments, blood bag or blood transfusion tube are connected to outlet valve 242 to collect filtered blood before blood outflow.Work as work
When plug 400 does not translate, valve is preferably all closed.
In another embodiment, piston 400 passes through the mobile opening inlet valve 302 of induction stroke, valve body 520 and outlet
Valve 242, while blood and fluid are extracted (for example, anti-freezing from blood source (for example, patient or collecting amount) or the blood bag of connection respectively
Liquid).Piston 400 is by the mobile closure inlet valve 302 and valve body 220 of compression stroke and opens outlet valve 242, to permit
Perhaps blood outflow outlet 240, into blood bag.
In another embodiment, piston 400 is by the mobile opening inlet valve 302 and valve body 520 of induction stroke, and
Blood is drawn into hollow body volume by filter.400 position of piston by hollow body volume and ambient enviroment it
Between be essentially equal try hard to keep and hold.When keeping 400 position of piston, all valves are preferably closed.Liquid storage device 320 with it is hollow
Main body 200 and the filter module 500 removed separate；The valve body 520 of closure preferably keeps hollow master during this process
Body volume is sterile and pressure.Liquid storage device 320 then reconnects to hollow body 200, and piston 400 passes through compression stroke
It is mobile to open valve body 520 and blood is flowed out by entrance 300.Initial liquid storage device 320 can use, new filter module
500 can be mounted or new liquid storage device 320 can be used in blood and go out from hollow body volume flow.This alternative solution can be another
Outer includes separating 400 shaft 440 of piston and handle 460 to keep 400 position of piston with piston head 420.
As used in the specification and in the claims, singulative " one (a/an) " and it is " described " include odd number and plural number
Both reference substances, unless the context clearly indicates otherwise.For example, term " filter " may include and be expected to include multiple mistakes
Filter.Sometimes, claim and disclosure may include such as " multiple ", " one or more " or "at least one"
Term；However, the missing of such term is not intended to mean that, and it is understood not to not consider plural number.
When before number designation or range (for example, for limit length or pressure) in use, term " about " or " big
Cause " indicate the approximation that can change in (+) or (-) 5%, 1% or 0.1%.All numberical range packets provided in this article
Include stated beginning number and end number.Term " generally " instruction is most of (that is, being more than 50%) or essentially all
Device, substance or composition.
As used herein, term " including (comprising) " or " including (comprises) " are intended to indicate that device, are
System and method include described element, and can also comprise any other element.For stated purpose, " substantially
By ... form " should indicate element that devices, systems, and methods include described and exclude it is any other have to combination it is basic
The element of importance.Therefore, the system or method being substantially made of element as defined herein will be not excluded for will not be substantial
Influence other materials, feature or the step of the basic and novel features of the claimed invention." by ... form " answer table
Showing device, system and method include described element and exclude to be more than any of insignificant or inessential element or step
Things.The embodiment limited by each in these transitional terms is in the scope of the present disclosure.
Examples included herein and explanation are by means of illustrating but showing the specific of the theme that can be put into practice without limitation
Embodiment.Other embodiments can use and deviate from it so that can carry out structure and logic substitutes and variation, without de-
From the scope of the present disclosure.If more than one theme is disclosed, such embodiment of inventive subject matter herein can be single
Solely or be referred to as term " invention ", be only for convenience and be not intended to initiatively by scope of the present application be limited to it is any individually
Invention or inventive concepts.Therefore, although described herein and description specific embodiment, in order to realize identical purpose
And calculate any arrangement can substitute shown in specific embodiment.The disclosure is intended to cover any and all of each embodiment
Modification or variation.Those skilled in the art are readily apparent that above example after consulting above description and do not specifically describe herein
Other embodiments combination.
Claims (16)
1. a kind of detachable filter module for haemofiltration apparatus comprising：
Filter housing, the filter housing are formed by one or more side walls, the filter housing have part or
Completely open proximal side and distal face；
Filter medium, the filter medium are placed in the filter housing；And
Valve body, the valve body are located in the distal end of the filter housing, and the valve body is being opened configuration and closed
It closes and is moved between configuring, wherein in the closed configuration, the valve body seals the distal side of the filter housing
Face.
2. detachable filter module according to claim 1, wherein the filter module be sized and by with
It is set to and is fixedly fitted in haemofiltration apparatus, and Fluid Sealing is formed with the inner wall of the haemofiltration apparatus.
3. detachable filter module according to claim 2 further comprises from described in the filter housing
One or more side wall sealing surfaces outstanding, wherein the sealing surfaces are configured to be pressed against the haemofiltration apparatus
The inner wall.
4. detachable filter module according to claim 3, wherein the filter housing and the sealing surfaces are
Whole.
5. detachable filter module according to claim 3, wherein the filter housing, the sealing surfaces and institute
It is whole to state valve body.
6. detachable filter module according to claim 1, wherein the filter medium is pleated.
7. detachable filter module according to claim 1, wherein the filter housing is cylindrical.
8. detachable filter module according to claim 2, wherein when forming negative pressure in the haemofiltration apparatus
When, the valve body is opened.
9. detachable filter module according to claim 1, wherein the valve body includes fin.
10. detachable filter module according to claim 1, wherein the filter housing is transparent.
11. a kind of filter module comprising：
Filter medium, the filter medium is by the pleating grid protocol that is folded with circular pattern；
Elastic housing, the elastic housing are disposed at least partially in around the filter medium；And
Mechanical body valve, the mechanical body valve are configured to mechanically seal the filter module.
12. filter module according to claim 11, wherein the pleating network includes gore, and wherein institute
It states in the circle that filter medium is located at around inner prop.
13. filter module according to claim 11, wherein the pleating network has multiple holes, the hole is set
Size passes through the hole at prevention clot and big biological particle, while haemocyte being allowed to pass through the hole.
14. filter module according to claim 11, wherein the mechanical body valve is opened when being subjected to negative pressure, to permit
Perhaps fluid flows through the filter medium, and is closed by environmental pressure or positive pressure.
15. filter module according to claim 11, wherein the mechanical body valve includes fin, the fin is outside
Portion's pressure is closed when being applied on the filter module, and when pressure in the filter module increases opens.
16. a kind of haemofiltration apparatus comprising：
Fluid absorbent means, the fluid absorbent means include fluid passage；And
Filter module according to claim 11, the filter module are placed in the described of the fluid absorbent means
In access.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662276817P | 2016-01-08 | 2016-01-08 | |
| US62/276,817 | 2016-01-08 | ||
| US15/018,800 | 2016-02-08 | ||
| US15/018,800 US10195320B2 (en) | 2012-04-12 | 2016-02-08 | Blood filtering component, apparatus, and method |
| PCT/US2016/035113 WO2017119924A1 (en) | 2016-01-08 | 2016-05-31 | Blood filtering component, apparatus, and method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108495663A true CN108495663A (en) | 2018-09-04 |
Family
ID=59273957
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201680077422.6A Pending CN108495663A (en) | 2016-01-08 | 2016-05-31 | Blood filtration component, device and method |
Country Status (8)
| Country | Link |
|---|---|
| CN (1) | CN108495663A (en) |
| BR (1) | BR112018013935B1 (en) |
| CA (1) | CA3010871A1 (en) |
| MX (1) | MX2018008291A (en) |
| MY (1) | MY189416A (en) |
| SG (1) | SG11201805721PA (en) |
| WO (1) | WO2017119924A1 (en) |
| ZA (1) | ZA201805287B (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109806632A (en) * | 2019-03-01 | 2019-05-28 | 中国科学院武汉物理与数学研究所 | A kind of Whole Blood Filtration device |
| CN111821529A (en) * | 2019-04-18 | 2020-10-27 | 段勇 | Nephrology dept is with novel hemodialysis conversion device |
| CN111821535A (en) * | 2020-07-23 | 2020-10-27 | 中国人民解放军总医院第八医学中心 | Virus filtering tube for blood and virus filtering device for blood |
| CN112263867A (en) * | 2020-09-24 | 2021-01-26 | 谢孟江 | Sewage treatment device |
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| CN1764483A (en) * | 2003-03-24 | 2006-04-26 | 株式会社Jms | Blood filter device and method of producing the same |
| US20100297577A1 (en) * | 2009-05-22 | 2010-11-25 | Howard Cohen | Strainer/filter unit for an aspirating filtration system and method thereof |
| CN103108685A (en) * | 2010-02-18 | 2013-05-15 | 爱康科技系统有限公司 | Filters |
| US20130270161A1 (en) * | 2012-04-12 | 2013-10-17 | Rajen Nirwal Kumar | Fluid filtering device and method |
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| US3661265A (en) * | 1970-07-27 | 1972-05-09 | Contemporary Research And Dev | Serum separator type container |
| DE4132480C2 (en) * | 1991-09-30 | 1996-04-11 | Kabe Labortechnik Gmbh | Blood collection device |
| US8608816B2 (en) * | 2012-01-10 | 2013-12-17 | Buffalo Filter Llc | Fluid filtration device and system |
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- 2016-05-31 SG SG11201805721PA patent/SG11201805721PA/en unknown
- 2016-05-31 BR BR112018013935-1A patent/BR112018013935B1/en active IP Right Grant
- 2016-05-31 CA CA3010871A patent/CA3010871A1/en active Pending
- 2016-05-31 MY MYPI2018702325A patent/MY189416A/en unknown
- 2016-05-31 MX MX2018008291A patent/MX2018008291A/en unknown
- 2016-05-31 WO PCT/US2016/035113 patent/WO2017119924A1/en active Application Filing
- 2016-05-31 CN CN201680077422.6A patent/CN108495663A/en active Pending
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2018
- 2018-08-10 ZA ZA2018/05287A patent/ZA201805287B/en unknown
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6143174A (en) * | 1996-09-05 | 2000-11-07 | Sartorius Ag | Filtration unit with pleated filtering elements |
| CN1764483A (en) * | 2003-03-24 | 2006-04-26 | 株式会社Jms | Blood filter device and method of producing the same |
| US20100297577A1 (en) * | 2009-05-22 | 2010-11-25 | Howard Cohen | Strainer/filter unit for an aspirating filtration system and method thereof |
| CN103108685A (en) * | 2010-02-18 | 2013-05-15 | 爱康科技系统有限公司 | Filters |
| US20130270161A1 (en) * | 2012-04-12 | 2013-10-17 | Rajen Nirwal Kumar | Fluid filtering device and method |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109806632A (en) * | 2019-03-01 | 2019-05-28 | 中国科学院武汉物理与数学研究所 | A kind of Whole Blood Filtration device |
| CN111821529A (en) * | 2019-04-18 | 2020-10-27 | 段勇 | Nephrology dept is with novel hemodialysis conversion device |
| CN111821535A (en) * | 2020-07-23 | 2020-10-27 | 中国人民解放军总医院第八医学中心 | Virus filtering tube for blood and virus filtering device for blood |
| CN111821535B (en) * | 2020-07-23 | 2023-06-02 | 中国人民解放军总医院第八医学中心 | Virus filter tube for blood and virus filter device for blood |
| CN112263867A (en) * | 2020-09-24 | 2021-01-26 | 谢孟江 | Sewage treatment device |
Also Published As
| Publication number | Publication date |
|---|---|
| SG11201805721PA (en) | 2018-07-30 |
| ZA201805287B (en) | 2019-07-31 |
| BR112018013935A2 (en) | 2019-02-19 |
| CA3010871A1 (en) | 2017-07-13 |
| MY189416A (en) | 2022-02-10 |
| MX2018008291A (en) | 2019-05-30 |
| BR112018013935B1 (en) | 2023-12-26 |
| WO2017119924A1 (en) | 2017-07-13 |
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