CN101711904B - Disposable precision filter infusion set for children - Google Patents
Disposable precision filter infusion set for children Download PDFInfo
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- CN101711904B CN101711904B CN2009102464457A CN200910246445A CN101711904B CN 101711904 B CN101711904 B CN 101711904B CN 2009102464457 A CN2009102464457 A CN 2009102464457A CN 200910246445 A CN200910246445 A CN 200910246445A CN 101711904 B CN101711904 B CN 101711904B
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- 238000001802 infusion Methods 0.000 title claims abstract description 27
- 238000001914 filtration Methods 0.000 claims abstract description 51
- 238000002347 injection Methods 0.000 claims abstract description 8
- 239000007924 injection Substances 0.000 claims abstract description 8
- 239000007788 liquid Substances 0.000 claims description 64
- 239000003814 drug Substances 0.000 claims description 41
- 239000000463 material Substances 0.000 claims description 20
- 239000011148 porous material Substances 0.000 claims description 17
- 239000012528 membrane Substances 0.000 claims description 15
- 239000012530 fluid Substances 0.000 claims description 13
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 12
- 238000001179 sorption measurement Methods 0.000 claims description 6
- 229950000845 politef Drugs 0.000 claims description 5
- XECAHXYUAAWDEL-UHFFFAOYSA-N acrylonitrile butadiene styrene Chemical compound C=CC=C.C=CC#N.C=CC1=CC=CC=C1 XECAHXYUAAWDEL-UHFFFAOYSA-N 0.000 claims description 4
- 229920000122 acrylonitrile butadiene styrene Polymers 0.000 claims description 4
- 239000004676 acrylonitrile butadiene styrene Substances 0.000 claims description 4
- 238000001990 intravenous administration Methods 0.000 claims description 4
- 229920002725 thermoplastic elastomer Polymers 0.000 claims description 4
- 239000004695 Polyether sulfone Substances 0.000 claims description 3
- 229920006393 polyether sulfone Polymers 0.000 claims description 3
- 229920002379 silicone rubber Polymers 0.000 claims description 3
- 239000004945 silicone rubber Substances 0.000 claims description 3
- 229920000098 polyolefin Polymers 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 9
- 230000008901 benefit Effects 0.000 abstract description 2
- 210000003462 vein Anatomy 0.000 abstract description 2
- 241001411320 Eriogonum inflatum Species 0.000 abstract 2
- 231100000956 nontoxicity Toxicity 0.000 abstract 1
- 238000000034 method Methods 0.000 description 8
- 230000008569 process Effects 0.000 description 8
- 239000007789 gas Substances 0.000 description 7
- 238000009825 accumulation Methods 0.000 description 3
- 210000004204 blood vessel Anatomy 0.000 description 3
- 239000004531 microgranule Substances 0.000 description 3
- 208000005189 Embolism Diseases 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- JHIVVAPYMSGYDF-UHFFFAOYSA-N cyclohexanone Chemical group O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 description 2
- 238000007872 degassing Methods 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
- 230000003000 nontoxic effect Effects 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 2
- 239000004810 polytetrafluoroethylene Substances 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 238000009423 ventilation Methods 0.000 description 2
- 206010001526 Air embolism Diseases 0.000 description 1
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- 208000031729 Bacteremia Diseases 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 229920002943 EPDM rubber Polymers 0.000 description 1
- 244000286663 Ficus elastica Species 0.000 description 1
- 206010018691 Granuloma Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 230000036783 anaphylactic response Effects 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 238000009455 aseptic packaging Methods 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
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- 230000004054 inflammatory process Effects 0.000 description 1
- 238000001746 injection moulding Methods 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 238000005374 membrane filtration Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000013618 particulate matter Substances 0.000 description 1
- 208000001297 phlebitis Diseases 0.000 description 1
- -1 polytetrafluoroethylene Polymers 0.000 description 1
- 210000001147 pulmonary artery Anatomy 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 210000005245 right atrium Anatomy 0.000 description 1
- 210000005241 right ventricle Anatomy 0.000 description 1
- 229920000260 silastic Polymers 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 206010043554 thrombocytopenia Diseases 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
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- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The invention provides a disposable precision filter infusion set for children, which is characterized by comprising a bottle stopper puncture outfit, a drip bucket, an injection part, a liquor filter, a flow regulator, a conical joint and a deep vein trocar which are successively connected by pipelines, wherein the bottom part of the bottle stopper puncture outfit is connected with an air filter with a filtering aperture of 0.2mu m; and the filtering aperture of the liquor filter is 0.2-2mu m. The invention has the advantages of no toxicity or harm and good liquor filtering effect, and is suitable for infants and children to use.
Description
Technical field
The invention provides a kind of disposable use precision filter infusion set for children, particularly suitable infant, child's clinical transfusion usefulness belong to the transfusion device technical field.
Background technology
Traditional infusion device: generally be divided into " non-air admission type transfusion device (having separate type air inlet device) " and " air admission type transfusion device " two kinds; As shown in Figure 1; Be traditional non-air admission type transfusion device sketch map; Described non-air admission type transfusion device is made up of the bottle plug puncture unit 11, dropping funnel 13, flow regulator 15, liquid medicine filter 16 and the intravenous needle 17 that connect through pipeline 14 successively, and described dropping funnel 13 is provided with injection member 12.As shown in Figure 2, be traditional air admission type transfusion device sketch map, described air admission type transfusion device is made up of the bottle plug puncture unit 21 and the air filter 23 that connect through pipeline 22.
Be that above-mentioned any transfusion device all has with shortcoming:
1. the transfusion device material generally uses polrvinyl chloride (PVC) material, and bonding with Ketohexamethylene, the PVC material has potential carcinogenecity, and Ketohexamethylene also has certain toxicity and carcinogenecity.
2. poor filtration effect: adult's blood capillary is generally 6～8 μ m; Child particularly infant blood capillary generally reaches 2～3 thinner μ m; General transfusion device is regardless of the adult in infusion process, the child uses, and the aperture of liquid medicine filter is generally greater than 15 μ m, and (greater than 2 μ m) do not have filter effect to small particle in the medicinal liquid; Bigger microgranule can directly cause the local circulation obstacle to cause that the blood vessel embolism severe patient causes local the obstruction and the oxygen supply deficiency, and histanoxia produces edema and inflammation; Less than can directly the causing thrombosis or cause erythrocyte aggregation that volume is increased of this footpath because foreign body is invaded tissue with blood flow, cause granuloma, and because how quantity can cause blood vessel embolism equally; Microgranule in the transfusion also can cause phlebitis, allergy, thrombocytopenia, bacteremia, anaphylaxis or the like simultaneously, and its harm to human body is that hide, secular.
3. liquid medicine filter does not have vent design.Air filter is when clinical transfusion, and medicinal liquid is prone to flow out from air filter, causes the air filter air inlet not smooth, and not even air inlet can't be carried out clinical transfusion, need change the air inlet part again.
Summary of the invention
The purpose of this invention is to provide a kind of nontoxic, medical filtration is effective, be suitable for the disposable use precision filter infusion set for children that infant and child use.
In order to achieve the above object; Technical scheme of the present invention provides a kind of disposable use precision filter infusion set for children; It is characterized in that comprise the bottle plug puncture unit, dropping funnel, injection member, liquid medicine filter, flow regulator, cone joint and the intravenous needle that connect through pipeline successively, the bottom of bottle plug puncture unit connects air filter; The pore size filter of said liquid medicine filter is 0.2～2 μ m, and the pore size filter of said air filter is 0.2 μ m.
The housing of the housing of said bottle plug puncture unit, air filter, injection member, liquid medicine filter, flow regulator and cone joint are all processed by acrylonitrile-butadiene-styrene copolymer (ABS), and dropping funnel and pipeline are all processed by polyolefins thermoplastic elastomer (TPO).
Said air filter comprises the housing of giving vent to anger; The housing of giving vent to anger connects air intake casing; The housing of giving vent to anger is provided with the gas outlet, and air intake casing is provided with air inlet, and the junction of give vent to anger housing and air intake casing and inboard, gas outlet all are provided with the first air filtration film; Be provided with the activated carbon adsorption material between two the first air filtration films, be provided with check valve in the gas outlet.
The material of the said first air filtration film is a politef, and its pore size filter is 0.2 μ m.
Described check valve is the silicone rubber tube that front end is provided with opening.
Described liquid medicine filter comprises the fluid housing; The fluid housing connects the feed liquor housing, and the fluid housing is provided with liquid outlet, and the feed liquor housing is provided with inlet; The feed liquor housing be respectively equipped with first from steam vent and second from steam vent; The junction of fluid housing and feed liquor housing is provided with liquid medicine filtering membrane, and first is provided with the second air filtration film from the steam vent inboard, and second is provided with the 3rd air filtration film from the inboard of steam vent.
The material of said liquid medicine filtering membrane is a polyether sulfone, and its pore size filter is 0.2～2 μ m.
The material of said second air filtration film and the 3rd air filtration film is a politef, and its pore size filter is all 0.2 μ m.
Principle of the present invention is:
Transfusion device is from the degassing function principle: degassing function is to rely on the steam vent on the liquid medicine filter to realize, from the purpose of vent design: the one, prevent that the air that produces in the infusion process from getting into vena systemica with medicinal liquid; The 2nd, prevent at the inner chamber of liquid medicine filter medicinal liquid not to be had through liquid medicine filter because of producing too much air accumulation in the infusion process, cause transfusion to carry out.
Through selecting the aperture for use is 0.2 μ m～2 μ m hydrophilic liquid medicine filtering membranes, reaches to prevent that air from getting into human body with medicinal liquid.When medicinal liquid gets into the liquid medicine filter inner chamber by liquid feeding end; Liquid medicine filtering membrane is soaked into by medicinal liquid rapidly, and liquid forms tension force on the liquid medicine filtering membrane surface, and it is the pressure that the medical filtration film tension of 0.2 μ m needs 320KPa at least that air will overcome the aperture; The medical filtration film tension that overcomes the aperture and be 2 μ m needs the pressure of 40KPa at least; And clinical transfusion is 1m pressure reduction (being 10KPa), thus air do not have through liquid medicine filtering membrane, so just can't get into human body.
, prevent at the inner chamber of liquid medicine filter medicinal liquid not to be had through liquid medicine filter from steam vent through design on the liquid feeding end housing, cause transfusion to carry out because of producing too much air accumulation in the infusion process.As shown in Figure 4; On steam vent, be covered with the hydrophobic air filter membrane, blocking water of air filtration film pressed greater than 80KPa, and promptly liquid at least could be through the air filtration film under the pressure effect of 80KPa; Clinical transfusion is 1m pressure reduction (being 10KPa); So medicinal liquid does not have through the air filtration film, the air that on infusion process, produces then can be through the air filtration film by discharging from steam vent, so air can not assembled at the liquid medicine filter inner chamber.
Transfusion device air filtering function principle: air filter is placed two air filtration films; The centre is placed with the activated carbon adsorption material; After air gets into air filter by air inlet; After ground floor air filtration film, activated carbon adsorption material, second layer air filtration membrane filtration, absorption, clean relatively air flows out air filter by the gas outlet to air respectively, gets into infusion vessel through bottle plug puncture unit.
Air filter check valve principle: check valve is formed by injection molding by silastic material; It is cut off (like Fig. 6-2) in its top 1/3rd length; Then check valve is packed in the air filter; Air is got into by the air inlet of air filter when the transfusion beginning, and this moment, the top of check valve can be opened under the effect of air-flow; When medicinal liquid is back to air filter, at first can touch unidirectional top, the closure that this moment, the check valve top can be tightly under the effect of fluid pressure; When medicinal liquid when getting back to infusion vessel, the top of check valve can be opened under the effect of air-flow, so medicinal liquid does not reach the filter membrane in the air filter, thereby can keep air filter to continue ventilation.
Advantage of the present invention is:
1, adopts the medical macromolecular materials of non-PVC, to the human non-toxic side effect;
2, the liquid medicine filter pore size filter is little, is 0.2 μ m～2 μ m; Good filtration effect, liquid medicine filtering membrane to the rejection rate of the above particulate matter of 2 μ m in the medicinal liquid greater than 90%; The air filtration film to the rejection rate of the above microgranule of 0.3 μ m in the air greater than 90%;
3, liquid medicine filter has from vent design, and can discharge and in infusion process, produce the air that produces, the one, prevent that the air that produces in the infusion process from getting into body (behind the direct intravasation of air with medicinal liquid; Bring great potential safety hazard can for patient's life and health; It is at first to get into right atrium through vein behind the air admission blood vessel that severe patient can cause air embolism, gets into right ventricle again, blocks the pulmonary artery inlet then; Cause pulmonary's severe depletion of oxygen, it is dead immediately to cause the patient); The 2nd, prevent at the inner chamber of liquid medicine filter medicinal liquid not to be had through liquid medicine filter because of producing too much air accumulation in the infusion process, cause transfusion to carry out.
4, be provided with check valve in the air filter, can prevent that medicinal liquid is back in the air filter or the outflow air filter, can guarantee the lasting ventilation of air filter; The centre is placed with virus and the antibacterial that the activated carbon adsorption material is used for absorbed air.
Description of drawings
Fig. 1 is traditional non-air admission type transfusion device sketch map;
Fig. 2 is traditional air admission type transfusion device sketch map;
Fig. 3 is disposable use precision filter infusion set for children sketch map;
Fig. 4 is the liquid medicine filter sketch map;
Fig. 5 is the air filter sketch map;
Fig. 6 is the check valve sketch map.
The specific embodiment
Specify the present invention below in conjunction with embodiment.
Embodiment 1
As shown in Figure 3; Be disposable use precision filter infusion set for children sketch map; Described disposable use non-PVC precision filter infusion set for children comprises bottle plug puncture unit 1, dropping funnel 4, injection member 6, liquid medicine filter 7, flow regulator 8, cone joint 9 and the intravenous needle 10 that connects through pipeline 5 successively; The bottom of bottle plug puncture unit 1 connects air filter 3, and the pore size filter of said air filter 3 and liquid medicine filter 7 is all 1 μ m.Housing, flow regulator 8 and the cone joint 9 of the housing of said bottle plug puncture unit 1, air filter 3, injection member 6, liquid medicine filter 7 are all processed by ABS (757K), and dropping funnel 4 and pipeline 5 are all processed by TPO (EPDM+PP).
As shown in Figure 5, be the air filter sketch map, said air filter 3 comprises the housing 31 of giving vent to anger; The housing 31 of giving vent to anger connects air intake casing 33; The housing 31 of giving vent to anger is provided with gas outlet 35, and air intake casing 33 is provided with air inlet, and the junction and 35 inboards, gas outlet of give vent to anger housing 31 and air intake casing 33 all are provided with the first air filtration film 34; Be provided with activated carbon adsorption material 32 between two the first air filtration films 34, be provided with check valve 35 in the gas outlet 35.The material of the said first air filtration film 34 is a polytetrafluoroethylene (PTFE), and its pore size filter is 0.2 μ m.。As shown in Figure 6, be the check valve sketch map, described check valve 35 is provided with the silicone rubber tube (the big chemical industry company limited rubber plant in east, Shandong produces) of opening 61 for front end.
As shown in Figure 4; Be the liquid medicine filter sketch map, described liquid medicine filter 7 comprises fluid housing 72, and fluid housing 72 connects feed liquor housing 75; Fluid housing 72 is provided with liquid outlet; Feed liquor housing 75 is provided with inlet, feed liquor housing 75 be respectively equipped with first from steam vent 74 and second from steam vent 77, fluid housing 72 is provided with liquid medicine filtering membrane 71 with the junction of feed liquor housing 75; First is provided with the second air filtration film 73, the second from steam vent 74 inboards is provided with the 3rd air filtration film 76 from the inboard of steam vent 77.The material of said liquid medicine filtering membrane 71 is a polyether sulfone, and its pore size filter is 1 μ m.The material of said second air filtration film 73 and the 3rd air filtration film 76 is a politef, and its pore size filter is all 0.2 μ m.
Product of the present invention is disposable use aseptic medical equipment, is opened after the aseptic packaging and is manipulated by the clinical transfusion rule of operation by the professional health care personnel.
Embodiment 2
Be similar to embodiment 1, difference is that the pore size filter of liquid medicine filtering membrane 71 is 0.2 μ m.
Be similar to embodiment 1, difference is that the pore size filter of liquid medicine filtering membrane 71 is all 2 μ m.
Claims (7)
1. disposable use precision filter infusion set for children; It is characterized in that; Comprise the bottle plug puncture unit (1), dropping funnel (4), injection member (6), liquid medicine filter (7), flow regulator (8), cone joint (9) and the intravenous needle (10) that connect through pipeline (5) successively; The bottom of bottle plug puncture unit (1) connects air filter (3), and the pore size filter of said liquid medicine filter (7) is 0.2～2 μ m, and the pore size filter of said air filter (3) is 0.2 μ m; Said air filter (3) comprises the housing of giving vent to anger (31); The housing (31) of giving vent to anger connects air intake casing (33); The housing (31) of giving vent to anger is provided with gas outlet (35), and air intake casing (33) is provided with air inlet, and the housing of giving vent to anger (31) all is provided with the first air filtration film (34) with the junction and the inboard, gas outlet (35) of air intake casing (33); Be provided with activated carbon adsorption material (32) between two the first air filtration films (34), be provided with check valve (35) in gas outlet (35).
2. disposable use precision filter infusion set for children as claimed in claim 1; It is characterized in that; The housing of the housing of said bottle plug puncture unit (1), air filter (3), injection member (6), liquid medicine filter (7), flow regulator (8) and cone joint (9) are all processed by acrylonitrile-butadiene-styrene copolymer, and dropping funnel (4) and pipeline (5) are all processed by polyolefins thermoplastic elastomer.
3. disposable use precision filter infusion set for children as claimed in claim 1 is characterized in that the material of the said first air filtration film (34) is a politef, and its pore size filter is 0.2 μ m.
4. disposable use precision filter infusion set for children as claimed in claim 1 is characterized in that described check valve (35) is provided with the silicone rubber tube of opening (61) for front end.
5. disposable use precision filter infusion set for children as claimed in claim 1; It is characterized in that described liquid medicine filter (7) comprises fluid housing (72), fluid housing (72) connects feed liquor housing (75); Fluid housing (72) is provided with liquid outlet; Feed liquor housing (75) is provided with inlet, feed liquor housing (75) be respectively equipped with first from steam vent (74) and second from steam vent (77), the junction of fluid housing (72) and feed liquor housing (75) is provided with liquid medicine filtering membrane (71); First is provided with the second air filtration film (73) from steam vent (74) inboard, and second is provided with the 3rd air filtration film (76) from the inboard of steam vent (77).
6. disposable use precision filter infusion set for children as claimed in claim 5 is characterized in that the material of said liquid medicine filtering membrane (71) is a polyether sulfone, and its pore size filter is 0.2～2 μ m.
7. disposable use precision filter infusion set for children as claimed in claim 5 is characterized in that, the material of said second air filtration film (73) and the 3rd air filtration film (76) is a politef, and its pore size filter is all 0.2 μ m.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009102464457A CN101711904B (en) | 2009-11-23 | 2009-11-23 | Disposable precision filter infusion set for children |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009102464457A CN101711904B (en) | 2009-11-23 | 2009-11-23 | Disposable precision filter infusion set for children |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101711904A CN101711904A (en) | 2010-05-26 |
| CN101711904B true CN101711904B (en) | 2012-05-23 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009102464457A Active CN101711904B (en) | 2009-11-23 | 2009-11-23 | Disposable precision filter infusion set for children |
Country Status (1)
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| CN (1) | CN101711904B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102389599A (en) * | 2011-11-22 | 2012-03-28 | 济南国瑞医疗器械有限公司 | Disposable precise transfusion device for children |
| CN102526830A (en) * | 2012-01-18 | 2012-07-04 | 山东康力医疗器械科技有限公司 | Precise filter infusion set |
| CN103933637B (en) * | 2014-04-17 | 2015-10-28 | 高宏 | From exhaust gas filter type remaining needle |
| CN106310422A (en) * | 2015-06-23 | 2017-01-11 | 上海振浦医疗设备有限公司 | Disposable precise filtering infusion apparatus for filleting bacterial endotoxin |
| CN108815625A (en) * | 2018-07-17 | 2018-11-16 | 美昕医疗器械(昆山)有限公司 | A kind of infusion apparatus may filter that bubble |
| CN109893707A (en) * | 2019-04-16 | 2019-06-18 | 河南曙光汇知康生物科技股份有限公司 | A kind of bubble-free, full-automatic exhaust infusion set |
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2009
- 2009-11-23 CN CN2009102464457A patent/CN101711904B/en active Active
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| CN101711904A (en) | 2010-05-26 |
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Effective date of registration: 20240606 Address after: 201500 no.2758 Songjin Road, Zhangyan Town, Jinshan District, Shanghai (Zhangyan economic Park) Patentee after: Shanghai Zhenpu Medical Equipment Technology Group Co.,Ltd. Country or region after: China Address before: 200126 No. 24 Yang Xin Dong Road, Shanghai, Pudong New Area Patentee before: SHANGHAI ZHENPU MEDICAL EQUIPMENT CO.,LTD. Country or region before: China |