CN1084752A

CN1084752A - A kind of strong pain stop paste and preparation method thereof

Info

Publication number: CN1084752A
Application number: CN93101613A
Authority: CN
Inventors: 何天佐
Original assignee: Individual
Current assignee: Individual
Priority date: 1993-02-18
Filing date: 1993-02-18
Publication date: 1994-04-06
Anticipated expiration: 2013-02-18
Also published as: CN1044564C

Abstract

The invention discloses a kind of strong pain stop paste, it contains Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Aconiti Kusnezoffii, Olibanum, Myrrha, Herba Asari, broken Serpentis.Be applied on the carrier after making extractum.

Description

A kind of strong pain stop paste and preparation method thereof

The present invention relates to the novel externally applied ointment He Shi of a kind of orthopaedics strong pain stop paste and preparation method thereof.

Current, in the middle of the medicine for external use of orthopaedics therapy medicine, based on liniment, lotion, plaster, but these medicines have its limitation in the different demands of using central due to illness kind and patient.Especially present externally applied ointment, be affixed on the affected part after permeability poor, cause skin allergy easily, and since at present the carrier of externally applied ointment lack flexibility, skin-tightening discomfort during use, the long-time use of patient is difficult to accept, and directly has influence on the curative effect of medicine.How aponeurosis damnify in the middle of the orthopaedics disease, neuralgia, deep soft tissue's damage at present clinically lacks effective strong pain-relieving medicine for external use based on pain symptom.

The present invention then is the defective that exists in the above-mentioned prior art, has developed that a kind of to join the master with Chinese medicine be efficacy component, with the externally applied ointment that novel carriers is made, has the advantage that permeability is good, pain relieving power is strong.

The used prescription of ointment of the present invention is the secret recipe handed down in the family of He Shi orthopaedics successor He Tianzuo.He Shi orthopaedics is one of Sichuan, modern China traditional Chinese medical science orthopaedics three big famous schools, exhales you to found by the spy of Meng ethnic group, with going into another name for Sichuan Province clearly.He Shi orthopaedics melt illiteracy, full, Han nationality's medicine and pharmacology and modern age the doctor trained in Western medicine orthopaedics and tranmstology and biomechanics be one, its reason, method, side, medicine promptly have the Chinese medicine and pharmacy characteristic, establish one's own system again.With " Gu damage one card is from blood opinion, more heavily gas ", unique theoretical its signs that is such as " control bone and control meat earlier ".

The present invention had both met Chinese medicine cooperative effect principle and existing pharmacopeia standard with medicine, had special dose proportioning again; Manufacture method keep natural drug originality original flavor and ancient times secret proved recipe curative effect; Pharmaceutical carrier novelties etc. are the major technology feature.

The present invention realizes like this.

At first prepare ointment: fill a prescription following (consumption is a weight ratio)

Rhizoma Et Radix Notopterygii 10-20 Radix Angelicae Pubescentis 10-20 Radix Angelicae Sinensis 8-15 Rhizoma Chuanxiong 8-15

Radix Aconiti Kusnezoffii 5-10 Olibanum 8-15 Myrrha 8-15 Herba Asari 5-10

Broken Serpentis 5-10

Processing technique is

The crude drug crushed after being dried of above-mentioned prescription is become powder in the compound recipe; By medicated powder: the ratio (volume ratio) of wine or water=1: 2-5 is with pure highgrain wine, common drinkable water (50 ℃) dipping three times (each 10-30 minute) of heating respectively, and leaching also divides and contains impregnation liquid; The wine impregnation liquid mixes with water retting liquid after alkali presses the way of distillation to reclaim ethanol, is concentrated into proportion 1.5.

In the above-mentioned concentrated thick paste in the thick paste gross weight, in transferring cream, add benzoic acid 1%, 5% glycerol and Borneolum Syntheticum each 5%, 85%-90% ethanol 0.6%-1%.

The carrier of preparation plaster of the present invention.

Plaster carrier of the present invention is made up of two parts: the one, and tensoplast 2(such as commercially available Bandaid adhesive plaster), moreover be medical poisonless sponge 1, the two is combined into together according to shown in Figure 1, medical sponge 1 is attached on the tensoplast 2, as the carrier that absorbs the drug.

The preparation plaster:

Dosage by every obedient 5g, 7g, 9g ointment is applied to 4 * 6,8 * 10 respectively with ointment, 12 * 18(sponge area cm ²) on the carrier of specification, stick nontoxic lid lining paper, continuous at once 4 hours ultraviolet radiation, the sampling antibacterial culturing detect qualified after, be the non-toxic plastic bag of tinfoil paper with the medicine card internal layer of packing into, the bag mouth heat seal.Promptly get He Shi strong pain stop paste finished product.

Raw material of the present invention is easy to get, and method is easy to grasp, and is reliable for effect.Have stronger blood circulation promoting and blood stasis dispelling, the effect of removing obstruction in the collateral to relieve pain, for aponeurosis damnify, neuralgia, deep soft tissue's damage the obvious treatment effect is arranged, concurrent control carries out clinical observation on the therapeutic effect and uses this ointment 418 examples, Chinese medicine matched group 194 examples, western medicine group 78 examples.This ointment effective percentage＞90%, recovery rate＞88% is all apparently higher than matched group.The present invention had both fully extracted the active ingredient of medicine, did not change its physicochemical property again, had kept the originality original flavor of natural drug.Novel carrier, the saturating speed in the time of strengthening medicine with skin absorbs can keep effective wettability of ointment, and is firm with skin-adherent, is easy to coincide with the affected part body, and non-stimulated or sensitization is not subjected to solid plain restriction such as region, temperature, science, practical.

Embodiment

Prescription:

Rhizoma Et Radix Notopterygii 1000 gram Radix Angelicae Pubescentiss 1000 gram Radix Angelicae Sinensis 800 gram Rhizoma Chuanxiongs 800 grams

Radix Aconiti Kusnezoffii 500 gram Olibanums 800 gram Myrrhas 800 gram Herba Asaris 500 grams

Broken Serpentis 500 grams

Above-mentioned prescription drug is cleaned, in baking oven, dried 4-6 hour for 45 ℃, taking-up is put in shady and cool place and cools, and pulverizing is 16 purpose medicated powder, soaks with 52 ℃ of pure grain wines, the volume ratio of wine and medicated powder is 5: 1, temperature＜50 ℃, continuous dipping three times, each 30 minutes, gradation leaching soak is soaked in water in an identical manner again.The wine soak is put in the concentrating under reduced pressure pot, and controlled pressure ℃ exceeds with soak temperature＜60, carries out ethanol and reclaims, till stopping to ooze to ethanol.The soak that reclaims behind the ethanol is mixed with the water soak, put in the interlayer caldron, steam heated ℃ is exceeded with soak temperature＜65, is evaporated to water: the denseness of ointment=1: 1.45 gets final product, and must restrain by ointment 2270.Add benzene and add acid 23 grams, each 112 gram of 5% glycerol and Borneolum Syntheticum, ethanol 25 grams of 84%-90%, making the ointment denseness is 1: 1.Dosage standard by every obedient 9 grams is applied to 12 * 18(sponge area cm with ointment ²) standby carrier, lining, sterilization, detection, encapsulation promptly get 270 obedient He Shi strong pain stop pastes.

Claims

1, a kind of strong pain-relieving ointment is characterized in that it contains: (consumption is a weight ratio)

Radix Aconiti Kusnezoffii 5-10 Olibanum 8-15 Myrrha 8-15 Herba Asari 5-10

Broken Serpentis 5-10

2, according to the ointment of claim 1, it is characterized in that also adding in the above-mentioned ointment benzoic acid 1%, 5% glycerol and Borneolum Syntheticum each 5%, ethanol 0.6%-1%(percentage composition is in the ointment gross weight).

3,, it is characterized in that said concentration of alcohol is 84%-90% according to the ointment of claim 2.

4, a kind of preparation method of strong pain-relieving ointment is characterized in that earlier the medicine of following prescription being made extractum (consumption is a weight ratio):

Radix Aconiti Kusnezoffii 5-10 Olibanum 8-15 Myrrha 8-15 Herba Asari 5-10

Broken Serpentis 5-10

After getting above-mentioned crude drug drying, be ground into powder, by medicated powder: wine or water=1: the ratio 2-5(volume ratio) is with heat respectively dipping three times of brewing grains white spirit, common drinkable water, and leaching also divides and contains impregnation liquid, and the wine impregnation liquid reclaims ethanol through distillation under vacuum, mix with water retting liquid, be concentrated into proportion 1.5, in concentrating thick paste in the thick paste gross weight add benzoic acid 1%, 5% glycerol and Borneolum Syntheticum each 5%, ethanol 0.6%-1% is applied to resulting ointment on the plaster carrier.

5, according to the method for claim 4, temperature＜50 ℃ of wherein heating when soaking, the each 10-30 of soak time minute, adding concentration of ethanol in the thick paste was 84%-90%.

6, according to the method for claim 4, wherein said plaster carrier is made up of tensoplast (2) and medical sponge (1), and medical sponge (1) is attached to the rubberised layer of tensoplast (2), as the absorbed layer of pharmaceutical carrier.