CN108472303A - 用于治疗白内障的组合物 - Google Patents

用于治疗白内障的组合物 Download PDF

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Publication number
CN108472303A
CN108472303A CN201680055951.6A CN201680055951A CN108472303A CN 108472303 A CN108472303 A CN 108472303A CN 201680055951 A CN201680055951 A CN 201680055951A CN 108472303 A CN108472303 A CN 108472303A
Authority
CN
China
Prior art keywords
composition
cholestene
alcohol
steroids
cholesteric
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201680055951.6A
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English (en)
Chinese (zh)
Inventor
萨姆·L·恩固因
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Concores Co
Original Assignee
Concores Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Concores Co filed Critical Concores Co
Publication of CN108472303A publication Critical patent/CN108472303A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts or implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Inorganic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201680055951.6A 2015-07-27 2016-07-27 用于治疗白内障的组合物 Pending CN108472303A (zh)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201562197477P 2015-07-27 2015-07-27
US62/197,477 2015-07-27
US201562202518P 2015-08-07 2015-08-07
US62/202,518 2015-08-07
US201562252120P 2015-11-06 2015-11-06
US62/252,120 2015-11-06
US201662295267P 2016-02-15 2016-02-15
US62/295,267 2016-02-15
PCT/US2016/044337 WO2017019808A1 (en) 2015-07-27 2016-07-27 Compositions for the treatment of cataracts

Publications (1)

Publication Number Publication Date
CN108472303A true CN108472303A (zh) 2018-08-31

Family

ID=56616065

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201680055951.6A Pending CN108472303A (zh) 2015-07-27 2016-07-27 用于治疗白内障的组合物

Country Status (7)

Country Link
US (2) US10398709B2 (https=)
EP (1) EP3328389A1 (https=)
JP (1) JP2018522070A (https=)
CN (1) CN108472303A (https=)
AU (1) AU2016298951B2 (https=)
CA (1) CA2993196A1 (https=)
WO (1) WO2017019808A1 (https=)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023020536A1 (zh) * 2021-08-18 2023-02-23 广州润尔眼科生物科技有限公司 一种药物组合物及其制备方法和应用
WO2023020535A1 (zh) * 2021-08-18 2023-02-23 广州润尔眼科生物科技有限公司 甾体化合物在制备预防和/或治疗飞蚊症的药物中的应用
WO2023030430A1 (zh) 2021-09-03 2023-03-09 成都瑞沐生物医药科技有限公司 一种滴眼给药预防和/或治疗白内障的眼用制剂
CN118354765A (zh) * 2021-08-06 2024-07-16 福德维卡股份制公司 用于治疗视觉障碍的眼用组合物
TWI922733B (zh) 2021-08-18 2026-04-21 大陸商潤爾眼科藥物（廣州）有限公司 甾體化合物在製備治療飛蚊症的藥物中的用途

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WO2006047022A1 (en) 2004-10-25 2006-05-04 Virginia Commonwealth University Nuclear sulfated oxysterol, potent regulator of cholesterol homeostasis, for therapy of hypercholesterolemia, hyperlipidemia, and atherosclerosis
PL3639828T3 (pl) 2013-12-24 2022-05-02 Virginia Commonwealth University Zastosowanie utlenowanych siarczanów cholesterolu (ocs) w leczeniu ostrej niewydolności wątroby
US20180250313A1 (en) * 2015-09-08 2018-09-06 Viewpoint Therapeutics, Inc. Compounds and formulations for treating ophthalmic diseases
EP3494125B1 (en) 2016-08-02 2022-06-22 Virginia Commonwealth University Compositions comprising 5-cholesten-3, 25-diol, 3-sulfate (25hc3s) or pharmaceutically acceptable salt thereof and at least one cyclic oligosaccharide
WO2019097434A1 (en) * 2017-11-17 2019-05-23 Mahmood Piraee Combinations of lanosterol or 25-hydroxycholesterol including derivatives thereof useful in the treatment of lens disorders
EP3813794A4 (en) * 2018-06-27 2022-07-13 Cellix Bio Private Limited COMPOSITIONS AND METHODS OF TREATMENT EYE DISEASES
EP3955916A4 (en) * 2019-04-19 2023-01-25 Buck Institute for Research on Aging 25-HYDROXYCHOLESTEROL (25HC), A CRYAB AGGREGATION INHIBITOR, IS A NEW SENOLYTIC
KR20240134913A (ko) 2022-01-21 2024-09-10 센주 유에스에이, 인코포레이티드 수성 액제
KR20250134186A (ko) * 2022-12-23 2025-09-09 듀렉트 코퍼레이션 25-히드록시-콜레스트-5-엔-3-술페이트 콜린, 이의 제형 및 이의 제조 방법, 및 의학적 용도

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US4136250A (en) 1977-07-20 1979-01-23 Ciba-Geigy Corporation Polysiloxane hydrogels
US4548990A (en) 1983-08-15 1985-10-22 Ciba-Geigy Corporation Crosslinked, porous polymers for controlled drug delivery
US5192535A (en) 1988-02-08 1993-03-09 Insite Vision Incorporated Ophthalmic suspensions
US20020132758A1 (en) 2001-01-18 2002-09-19 Shell John W. Method for identifying compounds to treat medical pathologies associated with molecular crystallization
JP2005511713A (ja) * 2001-12-07 2005-04-28 ザ・リージェンツ・オブ・ザ・ユニバーシティー・オブ・カリフォルニア 加齢性黄斑変性についての処置
KR20150036578A (ko) 2012-07-17 2015-04-07 더 리젠츠 오브 더 유니버시티 오브 미시간 백내장의 치료를 위한 알파-크리스탈린 응집의 억제제
JP2015526515A (ja) 2012-08-31 2015-09-10 ボシュ・アンド・ロム・インコーポレイテッドＢａｕｓｃｈ ＆ Ｌｏｍｂ Ｉｎｃｏｒｐｏｒａｔｅｄ オメガ３脂肪酸を有する眼用組成物
AU2014360369B2 (en) * 2013-12-05 2019-11-07 University Of Miami Compositions and methods for reducing intraocular pressure
KR20170048426A (ko) 2014-08-22 2017-05-08 광저우 캉루이 바이오로지컬 파마슈티컬 테크놀로지 씨오., 엘티디. 시각 장애를 치료하기 위한 조성물 및 방법
WO2016029197A1 (en) * 2014-08-22 2016-02-25 Kang Zhang Compositions and methods to treat and/or prevent vision disorders of the lens of the eye

Non-Patent Citations (1)

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Title
No relevant documents disclosed *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118354765A (zh) * 2021-08-06 2024-07-16 福德维卡股份制公司 用于治疗视觉障碍的眼用组合物
WO2023020536A1 (zh) * 2021-08-18 2023-02-23 广州润尔眼科生物科技有限公司 一种药物组合物及其制备方法和应用
WO2023020535A1 (zh) * 2021-08-18 2023-02-23 广州润尔眼科生物科技有限公司 甾体化合物在制备预防和/或治疗飞蚊症的药物中的应用
CN117693346A (zh) * 2021-08-18 2024-03-12 广州润尔眼科生物科技有限公司 甾体化合物在制备预防和/或治疗飞蚊症的药物中的应用
CN117693346B (zh) * 2021-08-18 2026-02-10 润尔眼科药物（广州）有限公司 甾体化合物在制备预防和/或治疗飞蚊症的药物中的应用
TWI922733B (zh) 2021-08-18 2026-04-21 大陸商潤爾眼科藥物（廣州）有限公司 甾體化合物在製備治療飛蚊症的藥物中的用途
WO2023030430A1 (zh) 2021-09-03 2023-03-09 成都瑞沐生物医药科技有限公司 一种滴眼给药预防和/或治疗白内障的眼用制剂

Also Published As

Publication number Publication date
US20200016176A1 (en) 2020-01-16
AU2016298951A1 (en) 2018-02-22
US20170027961A1 (en) 2017-02-02
EP3328389A1 (en) 2018-06-06
AU2016298951B2 (en) 2019-07-04
JP2018522070A (ja) 2018-08-09
US10398709B2 (en) 2019-09-03
WO2017019808A1 (en) 2017-02-02
CA2993196A1 (en) 2017-02-02

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Application publication date: 20180831