CN108472131B - 具有减小的视觉干扰的多焦点镜片 - Google Patents

具有减小的视觉干扰的多焦点镜片 Download PDF

Info

Publication number
CN108472131B
CN108472131B CN201780007877.5A CN201780007877A CN108472131B CN 108472131 B CN108472131 B CN 108472131B CN 201780007877 A CN201780007877 A CN 201780007877A CN 108472131 B CN108472131 B CN 108472131B
Authority
CN
China
Prior art keywords
spherical aberration
lens
focal length
diffractive structure
focus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201780007877.5A
Other languages
English (en)
Chinese (zh)
Other versions
CN108472131A (zh
Inventor
M-T·崔
刘月爱
洪昕
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alcon Inc
Original Assignee
Novartis AG
Alcon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG, Alcon Inc filed Critical Novartis AG
Priority to CN202011088542.0A priority Critical patent/CN112043460B/zh
Publication of CN108472131A publication Critical patent/CN108472131A/zh
Application granted granted Critical
Publication of CN108472131B publication Critical patent/CN108472131B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses or corneal implants; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
    • A61F2/1616—Pseudo-accommodative, e.g. multifocal or enabling monovision
    • A61F2/1618—Multifocal lenses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses or corneal implants; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
    • A61F2/1637—Correcting aberrations caused by inhomogeneities; correcting intrinsic aberrations, e.g. of the cornea, of the surface of the natural lens, aspheric, cylindrical, toric lenses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses or corneal implants; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
    • A61F2/1637—Correcting aberrations caused by inhomogeneities; correcting intrinsic aberrations, e.g. of the cornea, of the surface of the natural lens, aspheric, cylindrical, toric lenses
    • A61F2/164—Aspheric lenses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses or corneal implants; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
    • A61F2/1654—Diffractive lenses
    • G—PHYSICS
    • G02—OPTICS
    • G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
    • G02C7/00—Optical parts
    • G02C7/02—Lenses; Lens systems ; Methods of designing lenses
    • G02C7/04—Contact lenses for the eyes
    • G02C7/041—Contact lenses for the eyes bifocal; multifocal
    • G—PHYSICS
    • G02—OPTICS
    • G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
    • G02C7/00—Optical parts
    • G02C7/02—Lenses; Lens systems ; Methods of designing lenses
    • G02C7/04—Contact lenses for the eyes
    • G02C7/041—Contact lenses for the eyes bifocal; multifocal
    • G02C7/042—Simultaneous type
    • G—PHYSICS
    • G02—OPTICS
    • G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
    • G02C7/00—Optical parts
    • G02C7/02—Lenses; Lens systems ; Methods of designing lenses
    • G02C7/04—Contact lenses for the eyes
    • G02C7/049—Contact lenses having special fitting or structural features achieved by special materials or material structures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses or corneal implants; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses or corneal implants; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2002/1681—Intraocular lenses having supporting structure for lens, e.g. haptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses or corneal implants; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2002/1681—Intraocular lenses having supporting structure for lens, e.g. haptics
    • A61F2002/1683—Intraocular lenses having supporting structure for lens, e.g. haptics having filiform haptics
    • G—PHYSICS
    • G02—OPTICS
    • G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
    • G02C2202/00—Generic optical aspects applicable to one or more of the subgroups of G02C7/00
    • G02C2202/20—Diffractive and Fresnel lenses or lens portions

Landscapes

  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Prostheses (AREA)
  • Eyeglasses (AREA)
  • Diffracting Gratings Or Hologram Optical Elements (AREA)
CN201780007877.5A 2016-02-24 2017-02-15 具有减小的视觉干扰的多焦点镜片 Active CN108472131B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202011088542.0A CN112043460B (zh) 2016-02-24 2017-02-15 眼科镜片和人工晶状体

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15/051,765 2016-02-24
US15/051,765 US10675146B2 (en) 2016-02-24 2016-02-24 Multifocal lens having reduced visual disturbances
PCT/IB2017/050850 WO2017145014A1 (en) 2016-02-24 2017-02-15 Multifocal lens having reduced visual disturbances

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202011088542.0A Division CN112043460B (zh) 2016-02-24 2017-02-15 眼科镜片和人工晶状体

Publications (2)

Publication Number Publication Date
CN108472131A CN108472131A (zh) 2018-08-31
CN108472131B true CN108472131B (zh) 2020-10-27

Family

ID=58159119

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201780007877.5A Active CN108472131B (zh) 2016-02-24 2017-02-15 具有减小的视觉干扰的多焦点镜片
CN202011088542.0A Active CN112043460B (zh) 2016-02-24 2017-02-15 眼科镜片和人工晶状体

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN202011088542.0A Active CN112043460B (zh) 2016-02-24 2017-02-15 眼科镜片和人工晶状体

Country Status (8)

Country Link
US (5) US10675146B2 (enExample)
EP (2) EP3419561B1 (enExample)
JP (4) JP6981987B2 (enExample)
CN (2) CN108472131B (enExample)
AU (3) AU2017222472B2 (enExample)
CA (1) CA3008217C (enExample)
ES (1) ES3024658T3 (enExample)
WO (1) WO2017145014A1 (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2890287B1 (en) 2012-08-31 2020-10-14 Amo Groningen B.V. Multi-ring lens, systems and methods for extended depth of focus
US10675146B2 (en) * 2016-02-24 2020-06-09 Alcon Inc. Multifocal lens having reduced visual disturbances
AU2018235011A1 (en) 2017-03-17 2019-10-24 Amo Groningen B.V. Diffractive intraocular lenses for extended range of vision
US11523897B2 (en) 2017-06-23 2022-12-13 Amo Groningen B.V. Intraocular lenses for presbyopia treatment
AU2018292024A1 (en) 2017-06-28 2020-01-02 Amo Groningen B.V. Diffractive lenses and related intraocular lenses for presbyopia treatment
WO2019002390A1 (en) 2017-06-28 2019-01-03 Amo Groningen B.V. EXTENDED BEACH AND ASSOCIATED INTRAOCULAR LENSES FOR THE TREATMENT OF PRESBYOPIA
US11327210B2 (en) 2017-06-30 2022-05-10 Amo Groningen B.V. Non-repeating echelettes and related intraocular lenses for presbyopia treatment
JP7568629B2 (ja) * 2018-09-13 2024-10-16 ハニータ レンズ リミテッド 多焦点眼内レンズ
CA3100676A1 (en) 2018-12-06 2020-06-11 Amo Groningen B.V. Diffractive lenses for presbyopia treatment
EP4085293B1 (en) 2019-12-30 2025-10-29 AMO Groningen B.V. Achromatic lenses with zone order mixing for vision treatment
CA3166089A1 (en) * 2019-12-30 2021-07-08 Amo Groningen B.V. Achromatic lenses for vision treatment
WO2021136617A1 (en) 2019-12-30 2021-07-08 Amo Groningen B.V. Lenses having diffractive profiles with irregular width for vision treatment
AU2021256909A1 (en) 2020-04-16 2022-09-15 Alcon Inc. Ophthalmic lenses having an extended depth of focus for improving intermediate vision
AU2021283398A1 (en) 2020-06-01 2023-01-05 Icares Medicus, Inc. Double-sided aspheric diffractive multifocal lens, manufacture, and uses thereof
EP4305488B1 (en) * 2021-03-09 2025-10-15 Tatvum Llc Intraocular lens providing extended depth of focus
WO2022249128A1 (en) * 2021-05-28 2022-12-01 Alcon Inc. Multifocal diffractive ophthalmic lenses with evenly spaced echelettes
US12379611B2 (en) 2021-06-14 2025-08-05 Alcon Inc. Diffractive contact lenses
US12393054B2 (en) * 2021-08-31 2025-08-19 Alcon Inc. Multifocal ophthalmic lens with extended depth-of-focus
CN120569663A (zh) 2023-02-28 2025-08-29 爱尔康公司 用于嵌入式隐形眼镜的彩色掩模
US20240399686A1 (en) 2023-06-01 2024-12-05 Alcon Inc. Method for making embedded hydrogel contact lenses
US20250164823A1 (en) 2023-11-20 2025-05-22 Alcon Inc. Embedded contact lens with a high refractive index insert therein

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6088543A (en) * 1997-06-18 2000-07-11 Nikon Corporation Optical transmission element, and illumination device employing this optical transmission element
AU2015201867A1 (en) * 2009-09-01 2015-04-30 Arthur Bradley Multifocal correction providing improved quality of vision

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0101293D0 (sv) 2001-04-11 2001-04-11 Pharmacia Groningen Bv Technical field of the invention
US7896916B2 (en) * 2002-11-29 2011-03-01 Amo Groningen B.V. Multifocal ophthalmic lens
BRPI0518378A2 (pt) * 2004-10-25 2008-11-18 Advanced Medical Optics Inc lente oftÁlmica com méltiplas placas de fase
US7922326B2 (en) * 2005-10-25 2011-04-12 Abbott Medical Optics Inc. Ophthalmic lens with multiple phase plates
US7969654B1 (en) * 2006-10-24 2011-06-28 Purdue Research Foundation Volume Fresnel zone plates fabricated by laser direct writing
US20090112314A1 (en) * 2007-10-25 2009-04-30 Sarver Edwin J Multi-focal intraocular lens with asymmetric point spread function
JP2008181094A (ja) * 2006-12-27 2008-08-07 Konica Minolta Opto Inc 背面投射装置
US8974526B2 (en) * 2007-08-27 2015-03-10 Amo Groningen B.V. Multizonal lens with extended depth of focus
US8231219B2 (en) * 2008-04-24 2012-07-31 Amo Groningen B.V. Diffractive lens exhibiting enhanced optical performance
JP5342244B2 (ja) 2009-01-06 2013-11-13 株式会社メニコン 無水晶体眼内レンズの製造方法
CA2771825C (en) * 2009-09-01 2018-08-21 Arthur Bradley Multifocal correction providing improved quality of vision
BE1019161A5 (fr) 2010-01-26 2012-04-03 Physiol Lentille intraoculaire.
US8556417B2 (en) 2012-02-02 2013-10-15 Novartis Ag Apodized hybrid diffractive-refractive IOL for pseudo-accommodation
TWI588560B (zh) * 2012-04-05 2017-06-21 布萊恩荷登視覺協會 用於屈光不正之鏡片、裝置、方法及系統
EP2890287B1 (en) * 2012-08-31 2020-10-14 Amo Groningen B.V. Multi-ring lens, systems and methods for extended depth of focus
WO2014059465A1 (en) * 2012-10-17 2014-04-24 Brien Holden Vision Institute Lenses, devices, methods and systems for refractive error
JP6161404B2 (ja) 2013-05-21 2017-07-12 株式会社メニコン 回折型多焦点眼用レンズおよびその製造方法
US10675146B2 (en) * 2016-02-24 2020-06-09 Alcon Inc. Multifocal lens having reduced visual disturbances

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6088543A (en) * 1997-06-18 2000-07-11 Nikon Corporation Optical transmission element, and illumination device employing this optical transmission element
AU2015201867A1 (en) * 2009-09-01 2015-04-30 Arthur Bradley Multifocal correction providing improved quality of vision

Also Published As

Publication number Publication date
AU2022203187A1 (en) 2022-06-02
JP7554329B2 (ja) 2024-09-19
US20200253722A1 (en) 2020-08-13
EP4509905A2 (en) 2025-02-19
CA3008217C (en) 2024-02-20
US10675146B2 (en) 2020-06-09
EP3419561A1 (en) 2019-01-02
CN112043460B (zh) 2023-11-28
CN108472131A (zh) 2018-08-31
EP3419561B1 (en) 2025-03-12
US12161550B2 (en) 2024-12-10
AU2017222472B2 (en) 2022-02-24
US20240024094A1 (en) 2024-01-25
AU2017222472A1 (en) 2018-07-05
JP2019507624A (ja) 2019-03-22
US11813160B2 (en) 2023-11-14
US20220280284A1 (en) 2022-09-08
EP4509905A3 (en) 2025-05-14
CA3008217A1 (en) 2017-08-31
AU2024227040A1 (en) 2024-10-24
JP7346523B2 (ja) 2023-09-19
JP6981987B2 (ja) 2021-12-17
AU2022203187B2 (en) 2024-07-04
US11364111B2 (en) 2022-06-21
US20250057645A1 (en) 2025-02-20
JP2022036082A (ja) 2022-03-04
CN112043460A (zh) 2020-12-08
JP2024164310A (ja) 2024-11-26
ES3024658T3 (en) 2025-06-05
WO2017145014A1 (en) 2017-08-31
JP2023165744A (ja) 2023-11-17
US20170239038A1 (en) 2017-08-24

Similar Documents

Publication Publication Date Title
CN108472131B (zh) 具有减小的视觉干扰的多焦点镜片
US11684469B2 (en) Multifocal lens having reduced chromatic aberrations
US20220244440A1 (en) Non-repeating echelettes and related intraocular lenses for presbyopia treatment
US10568734B2 (en) Adjusting the apodization pattern for diffractive IOLs
US11914229B2 (en) Diffractive lenses and related intraocular lenses for presbyopia treatment
US20140172088A1 (en) Method and system for providing an intraocular lens having an improved depth of field

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
TA01 Transfer of patent application right
TA01 Transfer of patent application right

Effective date of registration: 20200415

Address after: Fribourg

Applicant after: ALCON, Inc.

Address before: Texas in the United States

Applicant before: NOVARTIS AG

GR01 Patent grant
GR01 Patent grant