AU2017222472B2 - Multifocal lens having reduced visual disturbances - Google Patents

Multifocal lens having reduced visual disturbances Download PDF

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Publication number
AU2017222472B2
AU2017222472B2 AU2017222472A AU2017222472A AU2017222472B2 AU 2017222472 B2 AU2017222472 B2 AU 2017222472B2 AU 2017222472 A AU2017222472 A AU 2017222472A AU 2017222472 A AU2017222472 A AU 2017222472A AU 2017222472 B2 AU2017222472 B2 AU 2017222472B2
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AU
Australia
Prior art keywords
focus
spherical aberration
lens
ophthalmic lens
intensity peak
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Application number
AU2017222472A
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English (en)
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AU2017222472A1 (en
Inventor
Myoung-Taek Choi
Xin Hong
Yueai Liu
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Alcon Inc
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Alcon Inc
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Publication date
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Publication of AU2017222472A1 publication Critical patent/AU2017222472A1/en
Assigned to ALCON INC. reassignment ALCON INC. Request for Assignment Assignors: NOVARTIS AG
Application granted granted Critical
Publication of AU2017222472B2 publication Critical patent/AU2017222472B2/en
Priority to AU2022203187A priority Critical patent/AU2022203187B2/en
Priority to AU2024227040A priority patent/AU2024227040A1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/14Eye parts, e.g. lenses or corneal implants; Artificial eyes
    • A61F2/16Intraocular lenses
    • A61F2/1613Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
    • A61F2/1637Correcting aberrations caused by inhomogeneities; correcting intrinsic aberrations, e.g. of the cornea, of the surface of the natural lens, aspheric, cylindrical, toric lenses
    • A61F2/164Aspheric lenses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/14Eye parts, e.g. lenses or corneal implants; Artificial eyes
    • A61F2/16Intraocular lenses
    • A61F2/1613Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
    • A61F2/1616Pseudo-accommodative, e.g. multifocal or enabling monovision
    • A61F2/1618Multifocal lenses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/14Eye parts, e.g. lenses or corneal implants; Artificial eyes
    • A61F2/16Intraocular lenses
    • A61F2/1613Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
    • A61F2/1637Correcting aberrations caused by inhomogeneities; correcting intrinsic aberrations, e.g. of the cornea, of the surface of the natural lens, aspheric, cylindrical, toric lenses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/14Eye parts, e.g. lenses or corneal implants; Artificial eyes
    • A61F2/16Intraocular lenses
    • A61F2/1613Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
    • A61F2/1654Diffractive lenses
    • GPHYSICS
    • G02OPTICS
    • G02CSPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
    • G02C7/00Optical parts
    • G02C7/02Lenses; Lens systems ; Methods of designing lenses
    • G02C7/04Contact lenses for the eyes
    • G02C7/041Contact lenses for the eyes bifocal; multifocal
    • GPHYSICS
    • G02OPTICS
    • G02CSPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
    • G02C7/00Optical parts
    • G02C7/02Lenses; Lens systems ; Methods of designing lenses
    • G02C7/04Contact lenses for the eyes
    • G02C7/041Contact lenses for the eyes bifocal; multifocal
    • G02C7/042Simultaneous type
    • GPHYSICS
    • G02OPTICS
    • G02CSPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
    • G02C7/00Optical parts
    • G02C7/02Lenses; Lens systems ; Methods of designing lenses
    • G02C7/04Contact lenses for the eyes
    • G02C7/049Contact lenses having special fitting or structural features achieved by special materials or material structures
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/14Eye parts, e.g. lenses or corneal implants; Artificial eyes
    • A61F2/16Intraocular lenses
    • A61F2/1613Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/14Eye parts, e.g. lenses or corneal implants; Artificial eyes
    • A61F2/16Intraocular lenses
    • A61F2002/1681Intraocular lenses having supporting structure for lens, e.g. haptics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/14Eye parts, e.g. lenses or corneal implants; Artificial eyes
    • A61F2/16Intraocular lenses
    • A61F2002/1681Intraocular lenses having supporting structure for lens, e.g. haptics
    • A61F2002/1683Intraocular lenses having supporting structure for lens, e.g. haptics having filiform haptics
    • GPHYSICS
    • G02OPTICS
    • G02CSPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
    • G02C2202/00Generic optical aspects applicable to one or more of the subgroups of G02C7/00
    • G02C2202/20Diffractive and Fresnel lenses or lens portions

Landscapes

  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Prostheses (AREA)
  • Eyeglasses (AREA)
  • Diffracting Gratings Or Hologram Optical Elements (AREA)
AU2017222472A 2016-02-24 2017-02-15 Multifocal lens having reduced visual disturbances Active AU2017222472B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2022203187A AU2022203187B2 (en) 2016-02-24 2022-05-12 Multifocal lens having reduced visual disturbances
AU2024227040A AU2024227040A1 (en) 2016-02-24 2024-10-02 Multifocal lens having reduced visual disturbances

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15/051,765 2016-02-24
US15/051,765 US10675146B2 (en) 2016-02-24 2016-02-24 Multifocal lens having reduced visual disturbances
PCT/IB2017/050850 WO2017145014A1 (en) 2016-02-24 2017-02-15 Multifocal lens having reduced visual disturbances

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2022203187A Division AU2022203187B2 (en) 2016-02-24 2022-05-12 Multifocal lens having reduced visual disturbances

Publications (2)

Publication Number Publication Date
AU2017222472A1 AU2017222472A1 (en) 2018-07-05
AU2017222472B2 true AU2017222472B2 (en) 2022-02-24

Family

ID=58159119

Family Applications (3)

Application Number Title Priority Date Filing Date
AU2017222472A Active AU2017222472B2 (en) 2016-02-24 2017-02-15 Multifocal lens having reduced visual disturbances
AU2022203187A Active AU2022203187B2 (en) 2016-02-24 2022-05-12 Multifocal lens having reduced visual disturbances
AU2024227040A Pending AU2024227040A1 (en) 2016-02-24 2024-10-02 Multifocal lens having reduced visual disturbances

Family Applications After (2)

Application Number Title Priority Date Filing Date
AU2022203187A Active AU2022203187B2 (en) 2016-02-24 2022-05-12 Multifocal lens having reduced visual disturbances
AU2024227040A Pending AU2024227040A1 (en) 2016-02-24 2024-10-02 Multifocal lens having reduced visual disturbances

Country Status (8)

Country Link
US (5) US10675146B2 (enExample)
EP (2) EP3419561B1 (enExample)
JP (4) JP6981987B2 (enExample)
CN (2) CN108472131B (enExample)
AU (3) AU2017222472B2 (enExample)
CA (1) CA3008217C (enExample)
ES (1) ES3024658T3 (enExample)
WO (1) WO2017145014A1 (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2890287B1 (en) 2012-08-31 2020-10-14 Amo Groningen B.V. Multi-ring lens, systems and methods for extended depth of focus
US10675146B2 (en) * 2016-02-24 2020-06-09 Alcon Inc. Multifocal lens having reduced visual disturbances
AU2018235011A1 (en) 2017-03-17 2019-10-24 Amo Groningen B.V. Diffractive intraocular lenses for extended range of vision
US11523897B2 (en) 2017-06-23 2022-12-13 Amo Groningen B.V. Intraocular lenses for presbyopia treatment
AU2018292024A1 (en) 2017-06-28 2020-01-02 Amo Groningen B.V. Diffractive lenses and related intraocular lenses for presbyopia treatment
WO2019002390A1 (en) 2017-06-28 2019-01-03 Amo Groningen B.V. EXTENDED BEACH AND ASSOCIATED INTRAOCULAR LENSES FOR THE TREATMENT OF PRESBYOPIA
US11327210B2 (en) 2017-06-30 2022-05-10 Amo Groningen B.V. Non-repeating echelettes and related intraocular lenses for presbyopia treatment
JP7568629B2 (ja) * 2018-09-13 2024-10-16 ハニータ レンズ リミテッド 多焦点眼内レンズ
CA3100676A1 (en) 2018-12-06 2020-06-11 Amo Groningen B.V. Diffractive lenses for presbyopia treatment
EP4085293B1 (en) 2019-12-30 2025-10-29 AMO Groningen B.V. Achromatic lenses with zone order mixing for vision treatment
CA3166089A1 (en) * 2019-12-30 2021-07-08 Amo Groningen B.V. Achromatic lenses for vision treatment
WO2021136617A1 (en) 2019-12-30 2021-07-08 Amo Groningen B.V. Lenses having diffractive profiles with irregular width for vision treatment
AU2021256909A1 (en) 2020-04-16 2022-09-15 Alcon Inc. Ophthalmic lenses having an extended depth of focus for improving intermediate vision
AU2021283398A1 (en) 2020-06-01 2023-01-05 Icares Medicus, Inc. Double-sided aspheric diffractive multifocal lens, manufacture, and uses thereof
EP4305488B1 (en) * 2021-03-09 2025-10-15 Tatvum Llc Intraocular lens providing extended depth of focus
WO2022249128A1 (en) * 2021-05-28 2022-12-01 Alcon Inc. Multifocal diffractive ophthalmic lenses with evenly spaced echelettes
US12379611B2 (en) 2021-06-14 2025-08-05 Alcon Inc. Diffractive contact lenses
US12393054B2 (en) * 2021-08-31 2025-08-19 Alcon Inc. Multifocal ophthalmic lens with extended depth-of-focus
CN120569663A (zh) 2023-02-28 2025-08-29 爱尔康公司 用于嵌入式隐形眼镜的彩色掩模
US20240399686A1 (en) 2023-06-01 2024-12-05 Alcon Inc. Method for making embedded hydrogel contact lenses
US20250164823A1 (en) 2023-11-20 2025-05-22 Alcon Inc. Embedded contact lens with a high refractive index insert therein

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6088543A (en) * 1997-06-18 2000-07-11 Nikon Corporation Optical transmission element, and illumination device employing this optical transmission element
AU2015201867A1 (en) * 2009-09-01 2015-04-30 Arthur Bradley Multifocal correction providing improved quality of vision

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0101293D0 (sv) 2001-04-11 2001-04-11 Pharmacia Groningen Bv Technical field of the invention
US7896916B2 (en) * 2002-11-29 2011-03-01 Amo Groningen B.V. Multifocal ophthalmic lens
BRPI0518378A2 (pt) * 2004-10-25 2008-11-18 Advanced Medical Optics Inc lente oftÁlmica com méltiplas placas de fase
US7922326B2 (en) * 2005-10-25 2011-04-12 Abbott Medical Optics Inc. Ophthalmic lens with multiple phase plates
US7969654B1 (en) * 2006-10-24 2011-06-28 Purdue Research Foundation Volume Fresnel zone plates fabricated by laser direct writing
US20090112314A1 (en) * 2007-10-25 2009-04-30 Sarver Edwin J Multi-focal intraocular lens with asymmetric point spread function
JP2008181094A (ja) * 2006-12-27 2008-08-07 Konica Minolta Opto Inc 背面投射装置
US8974526B2 (en) * 2007-08-27 2015-03-10 Amo Groningen B.V. Multizonal lens with extended depth of focus
US8231219B2 (en) * 2008-04-24 2012-07-31 Amo Groningen B.V. Diffractive lens exhibiting enhanced optical performance
JP5342244B2 (ja) 2009-01-06 2013-11-13 株式会社メニコン 無水晶体眼内レンズの製造方法
CA2771825C (en) * 2009-09-01 2018-08-21 Arthur Bradley Multifocal correction providing improved quality of vision
BE1019161A5 (fr) 2010-01-26 2012-04-03 Physiol Lentille intraoculaire.
US8556417B2 (en) 2012-02-02 2013-10-15 Novartis Ag Apodized hybrid diffractive-refractive IOL for pseudo-accommodation
TWI588560B (zh) * 2012-04-05 2017-06-21 布萊恩荷登視覺協會 用於屈光不正之鏡片、裝置、方法及系統
EP2890287B1 (en) * 2012-08-31 2020-10-14 Amo Groningen B.V. Multi-ring lens, systems and methods for extended depth of focus
WO2014059465A1 (en) * 2012-10-17 2014-04-24 Brien Holden Vision Institute Lenses, devices, methods and systems for refractive error
JP6161404B2 (ja) 2013-05-21 2017-07-12 株式会社メニコン 回折型多焦点眼用レンズおよびその製造方法
US10675146B2 (en) * 2016-02-24 2020-06-09 Alcon Inc. Multifocal lens having reduced visual disturbances

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6088543A (en) * 1997-06-18 2000-07-11 Nikon Corporation Optical transmission element, and illumination device employing this optical transmission element
AU2015201867A1 (en) * 2009-09-01 2015-04-30 Arthur Bradley Multifocal correction providing improved quality of vision

Also Published As

Publication number Publication date
AU2022203187A1 (en) 2022-06-02
JP7554329B2 (ja) 2024-09-19
US20200253722A1 (en) 2020-08-13
EP4509905A2 (en) 2025-02-19
CA3008217C (en) 2024-02-20
US10675146B2 (en) 2020-06-09
EP3419561A1 (en) 2019-01-02
CN112043460B (zh) 2023-11-28
CN108472131A (zh) 2018-08-31
EP3419561B1 (en) 2025-03-12
US12161550B2 (en) 2024-12-10
US20240024094A1 (en) 2024-01-25
AU2017222472A1 (en) 2018-07-05
JP2019507624A (ja) 2019-03-22
US11813160B2 (en) 2023-11-14
US20220280284A1 (en) 2022-09-08
EP4509905A3 (en) 2025-05-14
CA3008217A1 (en) 2017-08-31
AU2024227040A1 (en) 2024-10-24
JP7346523B2 (ja) 2023-09-19
CN108472131B (zh) 2020-10-27
JP6981987B2 (ja) 2021-12-17
AU2022203187B2 (en) 2024-07-04
US11364111B2 (en) 2022-06-21
US20250057645A1 (en) 2025-02-20
JP2022036082A (ja) 2022-03-04
CN112043460A (zh) 2020-12-08
JP2024164310A (ja) 2024-11-26
ES3024658T3 (en) 2025-06-05
WO2017145014A1 (en) 2017-08-31
JP2023165744A (ja) 2023-11-17
US20170239038A1 (en) 2017-08-24

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