CN108452194A - It is a kind of that there is the antipyretic beverage for improving respiratory tract bacterial infection effect - Google Patents
It is a kind of that there is the antipyretic beverage for improving respiratory tract bacterial infection effect Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A23F3/00—Tea; Tea substitutes; Preparations thereof
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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Abstract
It is a kind of that there is the antipyretic beverage for improving respiratory tract bacterial infection effect, the active constituent of the antipyretic beverage to be made of elscholtiza, dried orange peel, strophanthus divaricatus, lophatherum gracile and Radix Glycyrrhizae.On the basis of oral antibiotic, add and drinks antipyretic beverage of the present invention, fever, nausea and vomiting, sore-throat, cough, body temperature symptom between 36.5 DEG C 39 DEG C can be improved, the course for the treatment of for shortening treatment, has the clinical symptoms of above-mentioned bacterial upper respiratory tract infection caused by air conditioner disease improved function.
Description
Technical field
The present invention relates to a kind of antipyretic beverages for having and improving respiratory tract bacterial infection effect.Belong to functional beverage technology
Field.
Background technology
The people of long-time work and study under air conditioner surroundings, because space is relatively closed, atmosphere draught-free, pathogenic microorganisms holds
It easily grows, and indoor/outdoor temperature-difference is larger, organism adaptation is bad, and initial stage will appear nasal obstruction, giddy, sneezing, as environment does not have
Change, repeated cold, when most of patient assessment, by Symptomatic medicine, but as environment does not change, patient is easy doctor
Repeated cold, later stage will appear fever, nausea and vomiting, sore-throat, cough, yellow viscous phlegm and body temperature and rise, laboratory leucocyte
Rise, bacterium infection sign occur, the later stage usually needs to use antibiotic therapy.Special medicine or health products there is no to use at present
In the symptom for improving above-mentioned air conditioner disease, also no pertinent literature is reported and the products such as antipyretic beverage can improve above-mentioned air conditioner disease
Symptom.
Invention content
The object of the invention is intended to provide a kind of antipyretic beverage for having and improving respiratory tract bacterial infection effect, the herbal tea drink
The active constituent of material is made by the raw medicinal materials such as elscholtiza, dried orange peel, strophanthus divaricatus, lophatherum gracile and Radix Glycyrrhizae.In oral antibiotic
On the basis of, add and drink antipyretic beverage of the present invention, fever, nausea and vomiting, sore-throat, cough, body temperature can be improved 36.5
Symptom between DEG C -39 DEG C, shortens the course for the treatment of of treatment, for the clinical condition of above-mentioned bacterial upper respiratory tract infection caused by air conditioner disease
Shape has improved function.
Technical solution of the present invention is as follows：
The present invention provides a kind of antipyretic beverages for having and improving respiratory tract bacterial infection effect, which is characterized in that described
The active constituent of antipyretic beverage is made of elscholtiza, dried orange peel, strophanthus divaricatus, lophatherum gracile and Radix Glycyrrhizae.
Antipyretic beverage described above is made of specific Chinese medicine by special formulation, wherein preferably, elscholtiza 1
~4 parts by weight, preferably 1~2 parts by weight；Dried orange peel is 1~4 parts by weight, preferably 1~2 parts by weight；Strophanthus divaricatus is 5~10 weights
Measure part, preferably 6~8 parts by weight；2~6 parts by weight of lophatherum gracile, preferably 2~4 parts by weight；Radix Glycyrrhizae is 0.5~2 parts by weight, excellent
It is selected as 0.5~1 parts by weight.
As one of specific embodiment of the invention, present invention antipyretic beverage described above, wherein elscholtiza is 1~2 weight
Part is measured, dried orange peel is 1~2 parts by weight, and strophanthus divaricatus is 6~8 parts by weight, and lophatherum gracile is 2~4 parts by weight, and Radix Glycyrrhizae is 0.5~1 weight
Part；It is highly preferred that the antipyretic beverage, which is characterized in that elscholtiza is 0.75 parts by weight, and dried orange peel is 0.75 parts by weight, paniculata
Leaf is 3.75 parts by weight, and lophatherum gracile is 1.5 parts by weight, and Radix Glycyrrhizae is 0.5 parts by weight.
Present invention antipyretic beverage described above, use form are not particularly limited, for example, its can be abstract or
Infusion form.Such as active principle in above-mentioned antipyretic beverage formula can be extracted by extraction separation method conventional in the art
Abstract form, then be configured to herbal tea drink and drink, can also be impregnated as tealeaves, individually or together with tealeaves
It drinks.
As one of embodiment, the antipyretic beverage, which is characterized in that the antipyretic beverage is by the Chinese medicine
Individually extraction after it is extract obtained mixing and be made, or by the Chinese medicine mixing extract after it is extract obtained and obtained.
Preferably, antipyretic beverage described above, wherein the abstract is made through separation, purifying or the step of preparation
The form of oral solution, instant tea, particle or tablet.
Preferably, antipyretic beverage described above, which is characterized in that the antipyretic beverage is individually beaten by the Chinese medicine
It mixes after broken either crushing and is made or is made after being smashed or crushed by Chinese medicine mixing.
Present invention antipyretic beverage described above, if it is desired, it can also contain pharmaceutically or is subjected on food
Auxiliary material, for example, the auxiliary material be selected from corrigent (such as white sugar etc.), preservative (such as Tweens etc.).
As one of embodiment, present invention antipyretic beverage described above, the method system by including the following steps
：(1) water extracts, and medicinal material is extracted with water；(2) alcohol precipitates, and water extract obtained by step (1) is carried out alcohol precipitation with ethyl alcohol；(3)
Water sedimentation adds water to be precipitated after alcohol extract recycling ethyl alcohol obtained by step (2)；(4) step (3) acquired solution is used in ultrafiltration
Ultrafiltration membrance filter collects filtrate.
As the embodiment of the invention, a kind of antipyretic beverage described above is provided, it is characterised in that：
In the extracting in water step：The dosage of water is 8-10 times of medicinal material total weight；Extraction time is 1-3 times, preferably
For twice；Extraction time is 0.5-2h, preferably 1h；
The molecular cut off of the ultrafiltration membrane is preferably 100,000.
More specifically, antipyretic beverage described above, which is characterized in that it is by including that following method is made：Take prescription
The water of medicinal material, the 10 times of amounts and 8 times of amounts that are separately added into medicinal material total weight extracts twice, and each 1h, filtering merges extracting solution, subtracts
Pressure is concentrated into 3-4 times of medicinal material total weight, is cooled to room temperature, and it is 50% that ethyl alcohol to alcohol content, which is added, refrigerates or be stored at room temperature 12-
For 24 hours, it filters, filtrate decompression is concentrated, be cooled to room temperature, aqueous precipitation refrigerates 12h, and centrifugate is by centrifugation through molecular cut off
100000 ultrafiltration membrane ultrafiltration, obtains ultrafiltrate.
Antipyretic beverage described above, if it is desired, corrigent can also be added into ultrafiltrate, add water, sterilize；
Present invention antipyretic beverage described above, can be made suitable form, for example, granule, oral solution, tablet or
Person's infusion form etc..
As another object of the present invention, the application of antipyretic beverage described above is also provided.It provides of the present invention
Application of the antipyretic beverage in preparing the drink for improving respiratory tract bacterial infection effect；Preferably, it is used in Perorally administrable antimicrobial
On the basis of element plus the drink is drunk to improve the clinical symptoms of bacterial upper respiratory tract infection or shorten treatment course；Preferably,
It is used to prepare bacterial upper respiratory tract infection caused by improving air conditioner disease.
Present invention antipyretic beverage described above is directly soaked after can mixing the raw material of above-mentioned antipyretic beverage
It drinks, mixes or first mix after the raw material of above-mentioned antipyretic beverage can also being smashed and smash afterwards, soak and drink, it can also be by upper
State antipyretic beverage made of the extract that either method is prepared.
The antipyretic beverage of the present invention, raw material are grouped as by specific group, on the basis of oral antibiotic, add and drink this hair
The bright antipyretic beverage, can improve fever, nausea and vomiting, sore-throat, cough, the body temperature symptom between 36.5 DEG C -39 DEG C, contract
The course for the treatment of of short treatment has the clinical symptoms of above-mentioned bacterial upper respiratory tract infection caused by air conditioner disease improved function, makes
This part sub-health population is restored in normal health crowd, normally life and work.
Description of the drawings
Fig. 1：The HPLC collection of illustrative plates of the final liquid of embodiment 1.
In figure, abscissa is the delivery time, and unit min, ordinate is response, unit mAU.
Specific implementation mode
The specific implementation mode of the present invention is described in detail below.It should be understood that described herein specific
Embodiment is merely to illustrate and explain the present invention, and is not intended to restrict the invention.
Embodiment 1
1.1 reagent：
Elscholtiza, dried orange peel, strophanthus divaricatus, lophatherum gracile and Radix Glycyrrhizae are purchased from Zhuhai Garbo pharmacy of China.
Aurantiamarin reference substance (Zhong Jian institutes, 110721-201316), chromatography methanol (Merck, JB037207), glacial acetic acid are (wide
Chemical Co., Ltd., Factory of Dongguang China, lot number 20100920)；Absolute ethyl alcohol (Guangzhou Chemical Reagent Factory, 20160501-2).
1.2 instrument and equipment：
Shell type thermostat (medical apparatus and instruments factory of Haining City Xinhua, TC-15 types), Rotary Evaporators (love is bright), digital display thermostatted water
Bath (Changzhou Ao Hua Instrument Ltd., HH-6 types), electronic balance (Balance (one hundred human relations this), model：BWS-6-SW),
Electronic balance (plum Teller MS205DU), HPLC (Agilient 1260)；Circulation vacuum pump (Shanghai is sub- flourish, SHZ-III types).
1.3 compositions are as follows：
The preparation of 1.4 antipyretic beverages：It (is respectively twice that medicinal material is total to take the medicinal material of 10 times of dosages of recipe quantity, extracting in water
10 times of amounts, the 8 times of amounts of weight；Each 1h), first time, second of extracting solution are obtained respectively, and filtration merges extracting solution, obtains and close twice
And liquid, it is concentrated under reduced pressure into 3-4 times of medicinal material total amount, obtains merging concentrate, is let cool to room temperature, ethyl alcohol to alcohol content, which is added, is
50%, 12-24h is refrigerated or be stored at room temperature, is filtered, is obtained alcohol precipitation filtered fluid, be concentrated under reduced pressure into no alcohol taste, obtain alcohol precipitation concentrate, put
It is cooled to room temperature, aqueous precipitation refrigerates 12h, obtains the dense refrigeration liquid of water, centrifuges, and collects centrifugate, centrifugate is through ultrafiltration membrane (retention point
Son 10 ten thousand) ultrafiltration of amount, collect ultrafiltrate, add water to be settled to total amount, obtain final liquid, and final liquid is carried out HPLC detections, inspection
Survey method is as described below, and HPLC collection of illustrative plates is shown in Fig. 1 (1 prescription/500ml).(remarks：The non-sugaring flavoring of this experiment, final liquid is not
Make sterilizing to investigate).In figure, the peaks retention time 17.044min or so are aurantiamarin.
The HPLC detection methods of 1.5 aurantiamarins：
HPLC instruments：Agilent 1260, number NE090；C18 columns：Agilent ZORBAX SB-C18 5u250*
4.6mm；Sample size：5ul；Flow velocity：1.0ml/min；Column temperature：30℃；Detector：DAD λ=283nm；Mobile phase：B phases are first
Alcohol, D phases are 2.2% acetic acid water：0-25min:35% (B), 65% (D)；
25.01-30min:35% (B) → 70% (B), 65% (D) → 30% (D)；30-35min:70% (B) → 100%
(B),
30% (D) → 0% (D)；35-45min:100% (B), 0% (D)；After run 12min.
1.6 experimental records and detection result of calculation such as following table：
Remarks：Total hesperidin content is to convert data after sampling in table.
The appearance character of 1.7 liquids see the table below：
Antipyretic beverage nutritional ingredient made from 1.8 1.4 is detected by China Guangzhou Analysis ＆. Test Center, testing result
It see the table below：
In summary, this technique can retain most main active principle in antipyretic beverage prescription, and technical process is from medicine
The total solid substance total yield of material extracting solution to final liquid is 46.22%, and the rate of transform of each step active principle is good, finished product face
Color is faint yellow, and clarity is high；In terms of nutritional ingredient angle, antipyretic beverage of the invention is the health of the low sodium of low albumen low fat
Herbal tea.In addition, this technique is carried in traditional water, alcohol precipitation process on the basis of, using high speed centrifugation, UF membrane ultrafiltration technology technology,
On the one hand it can retain herbal tea side's main effects material composition, on the other hand the new agent technologies such as ultrafiltration be used to improve the clear and bright of product
Degree improves appearance color, and retention macromolecular substances ensure the stability of product, simple and feasible, are easy to quality control, are suitble to industry
Metaplasia is produced.
Test example 1
To initially having a stuffy nose, dizzy, sneezing flu come medical patient, carry out Sputum culturing first, then controlled to the ill
It treats, after 3 days, the symptom of patient does not have controller, when patient goes to a doctor again after 3 days, selecting bacteria positive, while also complying with down
State selected, exclusion criteria, be randomly divided into 2 groups, one group of exclusive use cefotaxime, one group on the basis of using cefotaxime,
Add the herbal tea for drinking embodiment 1, carries out the comparative analysis of clinical efficacy.
1, research and design
This programme is by perspective, random, single blind, control clinical research methods design.
2, case selection
40 upper respiratory tract bacterial infection patients, meeting inclusion criteria, person is research object, and the wherein age is 22 years old -61
Year, average age are 50.5 years old, and two groups of patients are in the Indexes Comparisons such as age, gender, physical condition there was no significant difference (P ＞
0.05)。
3, standard
The selected standard of 3.1 respiratory tract bacterial infections
(1) symptom mainly shows fever, nausea and vomiting, sore-throat, cough, yellow viscous phlegm；
(2) laboratory leucocyte Indexes Abnormality (laboratory leucocyte：White blood cell count(WBC) (3.5-9.5/L), lymphocyte hundred
Point than (20.0-50.0LY%, neutrophil cell percentage (40.0-75.0NE%) are higher by normal range (NR), a raising in three,
It is defined as laboratory leucocyte Indexes Abnormality；
(3) the bacillary positive；
(4) without medical histories such as severe cardiac, liver, kidney, alimentary canal, nervous system, insanity and metabolic disorders；
(5) subject must be before the test to this experiment informed consent；
(6) subject can carry out good communication with researcher and can provide to complete experiment according to scheme；
3.2 standards excluded
(1) bacillary feminine gender；
(2) mild shower；
(3) body temperature needs antibiotic injection for treating at 39.0 DEG C or more.
3.3 exit standard
(1) course for the treatment of taken is insufficient；
(2) researcher thinks that subject's compliance is poor；
4, grouping and usage
Test group：Cefotaxime capsule (specification：0.25g, every 6 hours are primary, a 0.5g), it is cool made from embodiment 1
Tea (specification：500ml/ bottles, once in the morning and once at night, drink before meals, each 250ml), it has tea the 5th day and pays a return visit；
Control group：Cefotaxime capsule (specification：0.25g, every 6 hours are primary, a 0.5g), drink the water of equivalent.
5, observation index and efficacy determination
Symptom：Fever, nausea and vomiting, sore-throat, cough, yellow viscous phlegm and：
Slightly：(+)；Body temperature 36.5 DEG C -37 DEG C, vomiting is primary, cough does not influence sleep, the easy expectoration of yellow viscous phlegm, throat
Pain does not have dysphagia
Moderate：(++)；Body temperature vomits 2-3 times, cough influences sleep, the yellow phlegm that glues is not easy expectoration, throat at 37 DEG C -38 DEG C
Pain has dysphagia
Severe：(+++) body temperature is at 39 DEG C or more, the above exacerbation of symptoms, needs antibiotic, antibechic and Apophlegmatisant note
Penetrate liquid treatment；
Objective indicator：The bacillary positive；Laboratory leucocyte：White blood cell count(WBC) (3.5-9.5/L), cent lymphocytes
(20.0-50.0LY%, neutrophil cell percentage (40.0-75.0NE%) are higher by normal range (NR), and one increases in three, definition
For laboratory leucocyte Indexes Abnormality.
Subjective index：Subjective symptom is evaluated by above-mentioned standard, observes forward and backward 5 days phases of having tea of 2 groups of patients respectively
Clinical efficacy data behind pass, and carry out efficient comparative analysis.
Efficacy determination：Cure rate：For body temperature at 37-38 DEG C, vomiting 2-3 times (++), cough influence sleep (++), yellow viscous phlegm not
Easy expectoration (++), sore-throat have dysphagia (++)：Symptom all disappears after 5 days；
It is efficient：Body temperature is at 37 DEG C -38 DEG C, and vomiting 2-3 times (++), cough influence sleep (++), yellow viscous phlegm is not easy expectoration
(++), sore-throat have dysphagia (++)：Symptom disappearance 75% after 5 days.
6, statistical procedures
It is for statistical analysis with 9.12 softwares of SAS.Descriptive index is usedIt indicates, the comparison before having tea and after having tea
With paired t-test, the comparison variance analysis before two groups of control groups are had tea and after having tea and between test group compares and experiment component
Independent samples t-test is not carried out.Significance level α is 0.05.
As a result
1. the basic condition of the severity Scaling of selected cold patients
To initially having a stuffy nose, dizzy, sneezing flu come medical patient, carry out Sputum culturing first, then controlled to the ill
It treats, after 3 days, the symptom of patient does not have controller, when patient goes to a doctor again after 3 days, according to above-mentioned standard, selecting bacteria positive
40 upper respiratory tract bacterial infection patients, simultaneous selection laboratory leukocyte disorder, meet moderate (++)；Body temperature 37 DEG C-
38 DEG C, vomiting 2-3 time, cough influence that sleep, yellow viscous phlegm is not easy expectoration, sore-throat has dysphagia person, divide 2 groups, every group at random
20, wherein minimal ages 22 years old, max age 61 years old, average age 50.5 years old.
Test group 20, control group 20.The general information of patient is compared with the state of an illness, two groups of there was no significant difference (X2=
1.4323,P〉0.05)。
2. two groups have tea/water before compared with clinical after the 5th day
Compared with clinical after 5 days of test group and control group, two groups of bacterium all turns negative.Other index situations, as a result
It is shown in Table 1.
1. two groups of table is before having tea compared with the clinic after the 5th day (example, %)
Test group is not necessarily to treatment after 5 days, and control group has 10 patients to need then to treat.Experiments have shown that of the invention
Antipyretic beverage has the clinical symptoms of above-mentioned bacterial upper respiratory tract infection caused by air conditioner disease improved function, can shorten
The treatment course of antibiotic reduces the pain of patient.
The preferred embodiment of the present invention has been described above in detail, still, during present invention is not limited to the embodiments described above
Detail can carry out a variety of simple variants to technical scheme of the present invention within the scope of the technical concept of the present invention, this
A little simple variants all belong to the scope of protection of the present invention.
Claims (10)
1. a kind of having the antipyretic beverage for improving respiratory tract bacterial infection effect, which is characterized in that the activity of the antipyretic beverage
Ingredient is made of elscholtiza, dried orange peel, strophanthus divaricatus, lophatherum gracile and Radix Glycyrrhizae.
2. antipyretic beverage according to claim 1, which is characterized in that elscholtiza is 1~4 parts by weight, preferably 1~2 weight
Part；Dried orange peel is 1~4 parts by weight, preferably 1~2 parts by weight；Strophanthus divaricatus is 5~10 parts by weight, preferably 6~8 parts by weight；It is light
2~6 parts by weight of the leaf of bamboo, preferably 2~4 parts by weight；Radix Glycyrrhizae is 0.5~2 parts by weight, preferably 0.5~1 parts by weight.
3. according to the antipyretic beverage described in claim 1-2, wherein elscholtiza is 1~2 parts by weight, and dried orange peel is 1~2 parts by weight,
Strophanthus divaricatus is 6~8 parts by weight, and lophatherum gracile is 2~4 parts by weight, and Radix Glycyrrhizae is 0.5~1 parts by weight；Preferably, herbal tea drink
Material, which is characterized in that elscholtiza is 0.75 parts by weight, and dried orange peel is 0.75 parts by weight, and strophanthus divaricatus is 3.75 parts by weight, and lophatherum gracile is
1.5 parts by weight, Radix Glycyrrhizae are 0.5 parts by weight.
It is abstract or infusion form 4. according to the antipyretic beverage described in claim 1-3.
5. according to the antipyretic beverage described in claim 1-4, which is characterized in that the antipyretic beverage is by the Chinese medicine list
Solely extraction after it is extract obtained mixing and be made, or by the Chinese medicine mixing extract after it is extract obtained and obtained.
6. according to the antipyretic beverage described in claim 1-5, wherein the step of abstract is through separation, purifying or preparation
The form of oral solution, instant tea, particle or tablet is made.
7. according to the antipyretic beverage described in claim 1-6, which is characterized in that the antipyretic beverage is by the Chinese medicine list
It solely smashes and mixes after either crushing and be made or be made after being smashed or crushed by Chinese medicine mixing.
8. according to the antipyretic beverage described in claim 1-7, if it is desired, it can also contain pharmaceutically or on food can
The auxiliary material of receiving.
9. according to the antipyretic beverage described in claim 1-8, it is made by the method included the following steps：(1) water extracts,
Medicinal material is extracted with water；(2) alcohol precipitates, and water extract obtained by step (1) is carried out alcohol precipitation with ethyl alcohol；(3) water sedimentation, by step
(2) after gained alcohol extract recycling ethyl alcohol, water is added to be precipitated；(4) step (3) acquired solution ultrafiltration membrance filter is received in ultrafiltration
Collect filtrate.
10. claim 1-9 any one of them antipyretic beverage is preparing the drink for improving respiratory tract bacterial infection effect
In application；Preferably, the drink is drunk to improve bacterial upper respiratory tract infection for adding on the basis of oral antibiotic
Clinical symptoms shorten treatment course；Preferably, it is used to prepare bacterial upper respiratory tract infection caused by improving air conditioner disease.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710086053.3A CN108452194A (en) | 2017-02-17 | 2017-02-17 | It is a kind of that there is the antipyretic beverage for improving respiratory tract bacterial infection effect |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710086053.3A CN108452194A (en) | 2017-02-17 | 2017-02-17 | It is a kind of that there is the antipyretic beverage for improving respiratory tract bacterial infection effect |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108452194A true CN108452194A (en) | 2018-08-28 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710086053.3A Withdrawn CN108452194A (en) | 2017-02-17 | 2017-02-17 | It is a kind of that there is the antipyretic beverage for improving respiratory tract bacterial infection effect |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108452194A (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102578331A (en) * | 2012-02-17 | 2012-07-18 | 厦门欧凯科技有限公司 | Plant herbal tea concentrated solution and preparation method thereof |
-
2017
- 2017-02-17 CN CN201710086053.3A patent/CN108452194A/en not_active Withdrawn
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102578331A (en) * | 2012-02-17 | 2012-07-18 | 厦门欧凯科技有限公司 | Plant herbal tea concentrated solution and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 徐峰: "《本草纲目中的养生中药随手查》", 31 January 2015, 上海科学普及出版社 * |
| 范文昌等: "《广东地产清热解毒药物大全》", 31 July 2011, 中医古籍出版社 * |
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Application publication date: 20180828 |