CN108450001A - 作为转移性去势抵抗性前列腺癌(mCRPC)患者的治疗选择的生物标志物的雄激素受体变体7 - Google Patents

作为转移性去势抵抗性前列腺癌(mCRPC)患者的治疗选择的生物标志物的雄激素受体变体7 Download PDF

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Publication number
CN108450001A
CN108450001A CN201680068025.2A CN201680068025A CN108450001A CN 108450001 A CN108450001 A CN 108450001A CN 201680068025 A CN201680068025 A CN 201680068025A CN 108450001 A CN108450001 A CN 108450001A
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China
Prior art keywords
ctc
therapy
blood
ctcs
cell
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Pending
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CN201680068025.2A
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English (en)
Chinese (zh)
Inventor
瑞安·迪塔莫尔
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Epic Sciences Inc
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Epic Sciences Inc
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Priority to CN202410551097.9A priority Critical patent/CN118443942A/zh
Priority to CN202410551103.0A priority patent/CN118443943A/zh
Publication of CN108450001A publication Critical patent/CN108450001A/zh
Pending legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57555—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the prostate
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/723—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/60—Complex ways of combining multiple protein biomarkers for diagnosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/70—Mechanisms involved in disease identification
    • G01N2800/7023—(Hyper)proliferation
    • G01N2800/7028—Cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5026—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on cell morphology
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN201680068025.2A 2015-09-25 2016-09-23 作为转移性去势抵抗性前列腺癌(mCRPC)患者的治疗选择的生物标志物的雄激素受体变体7 Pending CN108450001A (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN202410551097.9A CN118443942A (zh) 2015-09-25 2016-09-23 作为转移性去势抵抗性前列腺癌(mCRPC)患者的治疗选择的生物标志物的雄激素受体变体7
CN202410551103.0A CN118443943A (zh) 2015-09-25 2016-09-23 作为转移性去势抵抗性前列腺癌(mCRPC)患者的治疗选择的生物标志物的雄激素受体变体7

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562233206P 2015-09-25 2015-09-25
US62/233,206 2015-09-25
PCT/US2016/053387 WO2017053763A2 (en) 2015-09-25 2016-09-23 ANDROGEN RECEPTOR VARIANT 7 AS A BIOMARKER FOR TREATMENT SELECTION IN PATIENTS WITH METASTATIC CASTRATION RESISTANT PROSTATE CANCER (mCRPC)

Related Child Applications (2)

Application Number Title Priority Date Filing Date
CN202410551103.0A Division CN118443943A (zh) 2015-09-25 2016-09-23 作为转移性去势抵抗性前列腺癌(mCRPC)患者的治疗选择的生物标志物的雄激素受体变体7
CN202410551097.9A Division CN118443942A (zh) 2015-09-25 2016-09-23 作为转移性去势抵抗性前列腺癌(mCRPC)患者的治疗选择的生物标志物的雄激素受体变体7

Publications (1)

Publication Number Publication Date
CN108450001A true CN108450001A (zh) 2018-08-24

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Family Applications (3)

Application Number Title Priority Date Filing Date
CN201680068025.2A Pending CN108450001A (zh) 2015-09-25 2016-09-23 作为转移性去势抵抗性前列腺癌(mCRPC)患者的治疗选择的生物标志物的雄激素受体变体7
CN202410551097.9A Pending CN118443942A (zh) 2015-09-25 2016-09-23 作为转移性去势抵抗性前列腺癌(mCRPC)患者的治疗选择的生物标志物的雄激素受体变体7
CN202410551103.0A Pending CN118443943A (zh) 2015-09-25 2016-09-23 作为转移性去势抵抗性前列腺癌(mCRPC)患者的治疗选择的生物标志物的雄激素受体变体7

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CN202410551097.9A Pending CN118443942A (zh) 2015-09-25 2016-09-23 作为转移性去势抵抗性前列腺癌(mCRPC)患者的治疗选择的生物标志物的雄激素受体变体7
CN202410551103.0A Pending CN118443943A (zh) 2015-09-25 2016-09-23 作为转移性去势抵抗性前列腺癌(mCRPC)患者的治疗选择的生物标志物的雄激素受体变体7

Country Status (9)

Country Link
US (2) US20190285636A1 (https=)
EP (1) EP3353553B1 (https=)
JP (1) JP6936231B2 (https=)
CN (3) CN108450001A (https=)
AU (1) AU2016325617A1 (https=)
CA (1) CA2999911A1 (https=)
EA (1) EA201890816A1 (https=)
IL (1) IL258318A (https=)
WO (1) WO2017053763A2 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101926117B1 (ko) * 2017-08-18 2018-12-06 주식회사 싸이토젠 안드로겐 수용체의 변이체 기반 전립선암환자 스크리닝 방법
US20220184086A1 (en) * 2019-03-28 2022-06-16 Cardiff Oncology, Inc. Plk1 inhibitors and psa levels in prostate cancer
EP4160181A4 (en) * 2020-05-28 2024-08-07 Wang, Daoxiang METHOD FOR PREPARING MULTIPLE STAINING SECTIONS FOR A CYTOPATHOLOGY SAMPLE

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150212089A1 (en) * 2014-01-30 2015-07-30 Epic Sciences, Inc. Circulating tumor cell diagnostics for biomarkers predictive of resistance to androgen receptor (ar) targeted therapies
US20150233927A1 (en) * 2012-09-19 2015-08-20 Cornell University Identifying taxane sensitivity in prostate cancer patients

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160266127A1 (en) * 2013-09-30 2016-09-15 Peter Kuhn Genotypic and Phenotypic Analysis of Circulating Tumor Cells to Monitor Tumor Evolution in Prostate Cancer Patients
EA201691496A1 (ru) * 2014-01-27 2016-12-30 Эпик Сайенсиз, Инк. Диагностика биомаркеров рака предстательной железы с помощью циркулирующих опухолевых клеток

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150233927A1 (en) * 2012-09-19 2015-08-20 Cornell University Identifying taxane sensitivity in prostate cancer patients
US20150212089A1 (en) * 2014-01-30 2015-07-30 Epic Sciences, Inc. Circulating tumor cell diagnostics for biomarkers predictive of resistance to androgen receptor (ar) targeted therapies

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
EMMANUEL S. ANTONARAKIS等: "Androgen Receptor Splice Variant 7 and Efficacy of Taxane Chemotherapy in Patients With Metastatic Castration-Resistant Prostate Cancer", 《JAMA ONCOL.》 *

Also Published As

Publication number Publication date
JP2018535432A (ja) 2018-11-29
JP6936231B2 (ja) 2021-09-15
AU2016325617A1 (en) 2018-04-19
WO2017053763A3 (en) 2017-12-21
EP3353553A4 (en) 2019-04-17
CN118443942A (zh) 2024-08-06
US20190285636A1 (en) 2019-09-19
EP3353553A2 (en) 2018-08-01
CA2999911A1 (en) 2017-03-30
CN118443943A (zh) 2024-08-06
EA201890816A1 (ru) 2018-09-28
US20240036047A1 (en) 2024-02-01
IL258318A (en) 2018-05-31
EP3353553B1 (en) 2021-11-17
WO2017053763A2 (en) 2017-03-30

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Application publication date: 20180824