CN108444801A - A kind of reaction capsule with reducing row's bubble structure - Google Patents
A kind of reaction capsule with reducing row's bubble structure Download PDFInfo
- Publication number
- CN108444801A CN108444801A CN201810449563.7A CN201810449563A CN108444801A CN 108444801 A CN108444801 A CN 108444801A CN 201810449563 A CN201810449563 A CN 201810449563A CN 108444801 A CN108444801 A CN 108444801A
- Authority
- CN
- China
- Prior art keywords
- reaction chamber
- rotating disk
- reaction
- bubble structure
- capsule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000006243 chemical reaction Methods 0.000 title claims abstract description 55
- 239000002775 capsule Substances 0.000 title claims abstract description 13
- 238000001514 detection method Methods 0.000 claims abstract description 18
- 210000002381 plasma Anatomy 0.000 claims description 20
- 239000003153 chemical reaction reagent Substances 0.000 claims description 5
- 230000007704 transition Effects 0.000 claims description 4
- 239000007788 liquid Substances 0.000 abstract description 7
- 210000004369 blood Anatomy 0.000 description 16
- 239000008280 blood Substances 0.000 description 16
- 210000004204 blood vessel Anatomy 0.000 description 11
- 210000003743 erythrocyte Anatomy 0.000 description 9
- 238000004321 preservation Methods 0.000 description 5
- 238000005452 bending Methods 0.000 description 4
- 230000007246 mechanism Effects 0.000 description 4
- 230000009471 action Effects 0.000 description 3
- 230000003287 optical effect Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 2
- 230000035484 reaction time Effects 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 238000009825 accumulation Methods 0.000 description 1
- 238000003759 clinical diagnosis Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000010183 spectrum analysis Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/38—Diluting, dispersing or mixing samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
Abstract
The present invention relates to a kind of reaction capsules for arranging bubble structure with reducing, it includes rotating disk, setting reaction chamber on the rotating pan and the more than two feeding pipes being connected with reaction chamber, it is communicated with exhaust pipe on the reaction chamber, exhaust storehouse is provided on the exhaust pipe；The reaction chamber setting of the present invention generates centrifugal force on the rotating pan, by the rotation of rotating disk and mixes the liquid in reaction chamber, and the exhaust storehouse on exhaust pipe can accelerate gas discharge effectively to avoid retaining bubble in reaction chamber, prevents from having an impact detection.
Description
Technical field
The present invention relates to detection instrument fields, and in particular to a kind of reaction capsule with reducing row's bubble structure.
Background technology
Blood testing is most commonly used pattern detection in biomedicine, clinical diagnosis, health quarantine diagnosis, but red thin
To the spectrum analysis in blood testing, there are prodigious interference for the presence of born of the same parents, therefore how quickly and easily to be isolated from whole blood
Serum is always the hot spot and difficulties of blood testing research.
Overwhelming majority hospital and laboratory still use super-magnum centrifuge separation serum and haemocyte at present, after whole blood separation
It is independent again to carry out mixing, and mixing needs individually complicated mixing machinery or by manually carrying out mixing, so not
It is difficult to ensure mixture homogeneity when can only increase the job costs of detection and artificial mixing and there may be bubble, to inspection
It surveys result and there is certain influence.
Invention content
Technical problem to be solved by the invention is to provide a kind of simple in structure and it is possible to prevente effectively from retain bubble
The reaction capsule of bubble structure is arranged with reducing.
The technical solution adopted in the present invention is：A kind of reaction capsule with reducing row's bubble structure comprising rotating disk is set
The more than two feeding pipes set reaction chamber on the rotating pan and be connected with reaction chamber, are communicated on the reaction chamber
Exhaust pipe is provided with exhaust storehouse on the exhaust pipe.
The inner wall of reaction chamber of the present invention is in arc transition.
Reaction chamber horizontal cross-section of the present invention is more than length radially along the length of rotating disk circumferential direction.
The horizontal cross-section of reaction chamber of the present invention is oval.
The rotation center that the short axle of reaction chamber of the present invention passes through rotating disk.
Feeding pipe of the present invention is two, respectively blood plasma delivery pipe and detection reagent delivery pipe.
Rotating disk of the present invention is circle, and the center of circle of rotating disk is rotation center.
The positive effect of the present invention is：The reaction chamber setting of the present invention on the rotating pan, is generated by the rotation of rotating disk
Centrifugal force mixes the liquid in reaction chamber, is located at the internal diameter that the exhaust storehouse internal diameter on exhaust pipe is more than exhaust pipe, increases
It is vented area of section, gas discharge can be accelerated effectively to avoid retaining bubble in reaction chamber, prevents from having an impact detection.
The arc transition inner wall of reaction chamber, which can effectively prevent liquid to carry out accumulation in corner, influences mixed effect, and mixing is more
Add and uniformly ensures accuracy in detection.The present invention is detected suitable for optical path, using optical path to reaction chamber in rotating disk rotary course
It is detected, increases reaction chamber in the length of rotating disk direction of rotation, the detection reaction time of sensor can be effectively increased, disappeared
Except detection error, testing result is more accurate.
Description of the drawings
Fig. 1 is schematic structural view of the invention；
Fig. 2 is reaction chamber sectional view of the present invention；
Fig. 3 is plasma separating unit structural schematic diagram of the present invention.
In the accompanying drawings, 1- rotating disks, 2- are into blood vessel, 3- whole blood chambers, 4- adding holes, 5- disengagement chambers, 501- Erythrocyte preservations
Portion, 502- blood plasma reservoir, 6- go out blood vessel, 7- center lines, 8- bending parts, 9- reaction chambers, 10- exhaust pipes, 11- feeding pipes, 12-
It is vented storehouse.
Specific implementation mode
As shown in attached drawing 1,2, the present invention includes rotating disk 1, the reaction chamber 9 that is arranged in rotating disk 1 and with reaction chamber 9
The inner wall of the more than two feeding pipes 11 being connected, reaction chamber 9 is in arc transition.Rotating disk 1 is mounted on rotating mechanism,
Rotating disk is driven to be rotated under the action of rotating mechanism, it is preferred that rotating disk 1 is using circle, and the center of circle of rotating disk 1 is
Axle center is rotated.Under the action of the centrifugal force that the different liquids entered in reaction chamber 9 generate in 1 rotary course of rotating disk
It is mixed, structure is very simple, and can ensure degree of mixedness.In the top of reaction chamber 9 of the present invention, setting optical path detects
Mechanism can directly be detected the liquid after mixing, realize integration detection, avoid occurring sample damage in transfer process
It becomes estranged pollution.
The rotating mechanism that driving tray type structure is rotated has had extensive application in the prior art, no longer carries out herein
It repeats.
Simultaneous reactions chamber 9 is also communicated with exhaust pipe 10, and the exhaust pipe 10 is connected with air, and is leaned in exhaust pipe 10
There are exhaust storehouse 12, the area of section in exhaust storehouse 12 to be more than the radial cross-sectional area of exhaust pipe 10 on one end of proximal response chamber 9, it can be with
The bubble discharge in reaction chamber 9 is accelerated to realize quick mixing.It can ensure that liquid can smoothly enter into reaction when in use in this way
In chamber 9, testing result will not be influenced because retaining bubble in reaction chamber 9, detection is more accurate.
9 horizontal cross-section of the reaction chamber is more than length radially along the length of 1 circumferential direction of rotating disk, preferably
, the horizontal cross-section of the reaction chamber 9 is oval, and its short axle passes through the rotation center of rotating disk 1.Increase reaction chamber to exist
The length of rotating disk direction of rotation can be effectively increased the detection reaction time of sensor, eliminate detection error, testing result is more
It is accurate to add.
The feeding pipe 11 is two, respectively blood plasma delivery pipe and detection reagent delivery pipe, while can be according to detection
The quantity of reagent increases the quantity of feeding pipe 11.In an embodiment of the present invention, feeding pipe is 3, including 1 blood plasma delivery pipe
And 2 detection reagent delivery pipes.
As shown in Fig. 3, the blood plasma delivery pipe of reaction chamber 9 of the present invention is connected to plasma separating unit, is detached by blood plasma
The blood plasma that device is isolated enters in reaction chamber 9.Shown plasma separating unit includes the disengagement chamber 5 being arranged in rotating disk 1
And what is be connected respectively with disengagement chamber 5 goes out blood vessel 6 into blood vessel 2 and for convey blood plasma for convey whole blood, blood plasma is defeated
Pipe is sent to be connected with blood vessel 6 is gone out.
The other end into blood vessel 2 is connected with whole blood chamber 3, is useful for that the adding hole of whole blood is added on whole blood chamber 3
4, the whole blood chamber 3 is less than the minimum range of disengagement chamber 5 and axis of rotation with the maximum distance of axis of rotation.Whole blood is added to
In whole blood chamber 3, under the action of rotating disk 1 rotates, whole blood is centrifuged through being entered in disengagement chamber 5 into blood vessel 2.Phase
For disengagement chamber 5, whole blood chamber 3 is apart from axis of rotation closer to whole blood can be effectively ensured in this way and can smoothly enter into disengagement chamber 5
It is interior.The disengagement chamber 5 passes through rotation along the center line 7 that the radial setting of rotating disk 1 is disengagement chamber 5 in the upright projection of rotating disk 1
The rotation center of disk 1, helps to ensure that centrifugal effect.
Since blood plasma is lighter, red blood cell is heavier, under the influence of centrifugal force, Erythrocyte preservation portion is formed in disengagement chamber
501 and blood plasma reservoir 502, Erythrocyte preservation portion is located at the outside of blood plasma reservoir, Erythrocyte preservation portion 501 in rotation
The distance of the heart is more than blood plasma reservoir 502 at a distance from rotation center.Since red blood cell accounts for about the 40% of whole blood, red blood cell is limited
The volumetric ratio of reservoir and blood plasma reservoir is 2:3, be connected into blood vessel 2 with Erythrocyte preservation portion, it is described go out blood vessel 6 and blood plasma
Reservoir is connected, and it is blood plasma that can be effectively ensured from the discharge of blood vessel 6 is gone out, and will not adulterate red blood cell, ensure accuracy in detection.
It is described go out blood vessel 6 on be provided with bending part 8, the bending part 8 is less than disengagement chamber 5 at a distance from the rotation center of rotating disk 1
With the minimum range of rotation center.Bending part 8 is closer apart from rotation center, and liquid needs the pressure of bigger just can be curved by this
Folding part 8 is then into feeding pipe 11.
The above embodiments are merely illustrative of the technical solutions of the present invention, rather than its limitations；Although with reference to the foregoing embodiments
Invention is explained in detail, it will be understood by those of ordinary skill in the art that：It still can be to previous embodiment
Recorded technical solution is modified or equivalent replacement of some of the technical features；And these are changed or replace
It changes, the spirit and scope for technical solution of the embodiment of the present invention that it does not separate the essence of the corresponding technical solution.
Claims (7)
1. a kind of reaction capsule with reducing row's bubble structure, it is characterised in that it includes rotating disk（1）, be arranged in rotating disk（1）
On reaction chamber（9）And and reaction chamber（9）The more than two feeding pipes being connected（11）, in the reaction chamber（9）Upper company
It is connected with exhaust pipe（10）, in the exhaust pipe（10）On be provided with exhaust storehouse（12）.
2. a kind of reaction capsule with reducing row's bubble structure according to claim 1, it is characterised in that the reaction chamber（9）
Inner wall be in arc transition.
3. a kind of reaction capsule with reducing row's bubble structure according to claim 1, it is characterised in that the reaction chamber（9）
Horizontal cross-section is along rotating disk（1）The length of circumferential direction is more than length radially.
4. a kind of reaction capsule with reducing row's bubble structure according to claim 3, it is characterised in that the reaction chamber（9）
Horizontal cross-section it is oval.
5. a kind of reaction capsule with reducing row's bubble structure according to claim 4, it is characterised in that the reaction chamber（9）
Short axle extended line pass through rotating disk（1）Rotation center.
6. a kind of reaction capsule with reducing row's bubble structure according to claim 1, it is characterised in that the feeding pipe
（11）It is two, respectively blood plasma delivery pipe and detection reagent delivery pipe.
7. a kind of reaction capsule with reducing row's bubble structure according to claim 1, it is characterised in that the rotating disk（1）
For circle, rotating disk（1）The center of circle be rotation center.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810449563.7A CN108444801A (en) | 2018-05-11 | 2018-05-11 | A kind of reaction capsule with reducing row's bubble structure |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810449563.7A CN108444801A (en) | 2018-05-11 | 2018-05-11 | A kind of reaction capsule with reducing row's bubble structure |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108444801A true CN108444801A (en) | 2018-08-24 |
Family
ID=63203570
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810449563.7A Pending CN108444801A (en) | 2018-05-11 | 2018-05-11 | A kind of reaction capsule with reducing row's bubble structure |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108444801A (en) |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4038151A (en) * | 1976-07-29 | 1977-07-26 | Mcdonnell Douglas Corporation | Card for use in an automated microbial detection system |
| US4756884A (en) * | 1985-08-05 | 1988-07-12 | Biotrack, Inc. | Capillary flow device |
| US4847205A (en) * | 1987-04-08 | 1989-07-11 | Martin Marietta Energy Systems, Inc. | Device and method for automated separation of a sample of whole blood into aliquots |
| WO1990013016A1 (en) * | 1989-04-26 | 1990-11-01 | Migrata Uk Ltd | Cuvette |
| JP2009150733A (en) * | 2007-12-20 | 2009-07-09 | Panasonic Corp | Living body analyzing device, and blood separation method using it |
| JP2011196849A (en) * | 2010-03-19 | 2011-10-06 | Rohm Co Ltd | Rotating analysis chip and measurement system using the same |
| CN103168226A (en) * | 2010-11-23 | 2013-06-19 | 生物梅里埃有限公司 | Improved sample test cards |
| CN208270311U (en) * | 2018-05-11 | 2018-12-21 | 石家庄禾柏生物技术股份有限公司 | A kind of reaction capsule with variable diameter row's bubble structure |
-
2018
- 2018-05-11 CN CN201810449563.7A patent/CN108444801A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4038151A (en) * | 1976-07-29 | 1977-07-26 | Mcdonnell Douglas Corporation | Card for use in an automated microbial detection system |
| US4756884A (en) * | 1985-08-05 | 1988-07-12 | Biotrack, Inc. | Capillary flow device |
| US4847205A (en) * | 1987-04-08 | 1989-07-11 | Martin Marietta Energy Systems, Inc. | Device and method for automated separation of a sample of whole blood into aliquots |
| WO1990013016A1 (en) * | 1989-04-26 | 1990-11-01 | Migrata Uk Ltd | Cuvette |
| JP2009150733A (en) * | 2007-12-20 | 2009-07-09 | Panasonic Corp | Living body analyzing device, and blood separation method using it |
| JP2011196849A (en) * | 2010-03-19 | 2011-10-06 | Rohm Co Ltd | Rotating analysis chip and measurement system using the same |
| CN103168226A (en) * | 2010-11-23 | 2013-06-19 | 生物梅里埃有限公司 | Improved sample test cards |
| CN208270311U (en) * | 2018-05-11 | 2018-12-21 | 石家庄禾柏生物技术股份有限公司 | A kind of reaction capsule with variable diameter row's bubble structure |
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