CN108434332A - 烧、烫伤用负离子壳聚糖复合喷剂及其制备方法 - Google Patents

烧、烫伤用负离子壳聚糖复合喷剂及其制备方法 Download PDF

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CN108434332A
CN108434332A CN201810498443.6A CN201810498443A CN108434332A CN 108434332 A CN108434332 A CN 108434332A CN 201810498443 A CN201810498443 A CN 201810498443A CN 108434332 A CN108434332 A CN 108434332A
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chitosan
anion
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陈月爱
赵思涵
马奋东
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Abstract

烧、烫伤用负离子壳聚糖复合喷剂及其制备方法，本发明的特点：1.利用壳聚糖的带阳离子的高分子碱性多糖聚合物特性：天然无毒、无抗原性。壳聚糖(chitosan)是甲壳素经脱乙酰化制得的一种高分子氨基多糖，又名几丁聚糖、甲壳胺，是目前世界上唯一带阳离子的高分子碱性多糖聚合物，天然无毒、无抗原性。分子链上丰富的羟基和氨基使其易发生化学反应而具备多种功能，具有止痛、止血、促进伤口愈合、减小瘢痕、抑菌、良好的生理相容性和生物可降解性等优异的性能。2.利用负离子的还原性可使烧、烫伤面不易被氧化，起到保护作用，并且负离子可增强人体免疫力和抗菌力。使烧、烫伤面更易治愈。3.以及中药白芨、三七、血竭很好的止血、化瘀、抗菌、止痛的作用。

Description

烧、烫伤用负离子壳聚糖复合喷剂及其制备方法
技术领域
烧、烫伤用负离子壳聚糖复合喷剂，属于生活日用品、医药、化学领域。
发明背景
烧、烫伤是一种常见的皮肤创伤。烧、烫伤时，机体血管内的液体渗出，引起组织水肿、组织坏死。大面积烧伤时，血管渗透性异常，丢失大量液体，创面疼痛，还可能引起休克。受损局部的感染、疼痛、创面久治不愈是皮肤烧伤后常见的并发症状。
发明内容
本发明的亮点在于：
1.利用壳聚糖的带阳离子的高分子碱性多糖聚合物特性：天然无毒、无抗原性。壳聚糖(chitosan)是甲壳素经脱乙酰化制得的一种高分子氨基多糖，又名几丁聚糖、甲壳胺，是目前世界上唯一带阳离子的高分子碱性多糖聚合物，天然无毒、无抗原性。分子链上丰富的羟基和氨基使其易发生化学反应而具备多种功能，具有止痛、止血、促进伤口愈合、减小瘢痕、抑菌、良好的生理相容性和生物可降解性等优异的性能。
壳聚糖是一种白色或灰白色半透明的粉状固体，无味、无臭、无毒，略带珍珠光泽。壳聚糖具有可降解性、良好的生物相容性和一定的抗菌性和搞肿瘤性能广泛应用于医药、食品、化工等行业，素有万能多糖的美誉。壳聚糖降解产物对人体无毒副作用，在体内不积蓄，无免疫原性，在生物医学领域得到很好的应用，如人工皮肤的创伤敷料。
2.利用负离子的还原性可使烧、烫伤面不易被氧化，起到保护作用，并且负离子可增强人体免疫力和抗菌力。使烧、烫伤面更易治愈。
3.以及应用中药白芨、三七、血竭很好的止血、化瘀、抗菌、止痛的作用。
(1)白芨是兰科多年生草本植物，性味苦甘涩，微寒，敛气，渗痰，止血。经生物低温提取的白芨提取液，含丰富的白芨胶，葡配甘露多聚糖，具有：收敛止血，消肿生肌，亲水性，无抗原性，无毒副作用。
(2)三七又名田七，金不换，是驰名中外的名贵药材。其根、茎提取液可用于皮肤的烧烫伤的止血化瘀、消肿止痛。
(3)血竭别名麒麟竭，棕榈科植物麒麟竭果实和藤茎中的树脂。血竭油外敷治疗慢性伤口，可达到湿性愈合敷料处理伤口治疗效果。
4.原料易取得，生产工艺安全、易操作，能保证产品性能稳定。
本发明的配方如下：壳聚糖(1.0-30.0)，纳米级的托玛琳粉(0.1-10.0)，古海岩粉(0.1-10.0)，清水石粉(0.1-10.0)，麦饭石粉(0.1-10.0)，水晶石粉(0.1-10.0)，白芨(2.0-18.0)、三七(2.0-18.0)、血竭(2.0-10.0)，去离子水100。
制备方法：
(1)用纳米粉碎技术，将可释放负离子的天然矿石：古海岩、托玛琳、清水石、麦饭石、水晶石进行超微粒化，按配比比例形成负离子混合粉体；
(2)利用超声波细胞粉碎机使超声波能在液体中产生分散效应，从而使液体产生空化的作用，分散稀土和各类无机矿物粉。本发明用去离子水，将上述(1)的负离子混合粉体进行充分分散，取得负离子粉体的液体。超声波粉碎机是加速化学、生物学、物理学的反应速度和加速液体脱气的理想装置。超声波粉碎机能配制近乎微米的百分之一大小的乳胶体；匀化″难混溶″的混合液；
(3)壳聚糖经生化、分离、纯化处理后，加入到负离子液中搅拌10分钟。再加入白芨、三七、血竭提取液，搅拌均匀可得到本发明。

Claims (6)

1.烧、烫伤用负离子壳聚糖复合喷剂及其制备方法，其特征在于，属于生活日用品、医药、化学领域。
2.烧、烫伤用负离子壳聚糖复合喷剂及其制备方法，其特征在于，利用壳聚糖的带阳离子的高分子碱性多糖聚合物特性：天然无毒、无抗原性。分子链上丰富的羟基和氨基使其易发生化学反应而具备多种功能，具有止痛、止血、促进伤口愈合、减小瘢痕、抑菌、良好的生理相容性和生物可降解性等优异的性能。
3.烧、烫伤用负离子壳聚糖复合喷剂及其制备方法，其特征在于，利用负离子的还原性可使烧、烫伤面不易被氧化，起到保护作用，并且负离子可增强人体免疫力和抗菌力。使烧、烫伤面更易治愈。
4.烧、烫伤用负离子壳聚糖复合喷剂及其制备方法，其特征在于，以及应用中药白芨、三七、血竭很好的止血、化瘀、抗菌、止痛的作用。
5.烧、烫伤用负离子壳聚糖复合喷剂及其制备方法，其特征在于，原料易取得，生产工艺安全、易操作，能保证产品性能稳定。
6.烧、烫伤用负离子壳聚糖复合喷剂及其制备方法，其特征在于，首先用纳米粉碎技术，将可释放负离子的天然矿石：古海岩、托玛琳、清水石、麦饭石、水晶石进行超微粒化，按配比比例形成负离子混合粉体；其次利用超声波细胞粉碎机使超声波能在液体中产生分散效应，将负离子混合粉体进行充分分散，取得负离子粉体的液体。再将壳聚糖经生化、分离、纯化处理后，加入到负离子液中搅拌10分钟。最后加入白芨、三七、血竭提取液，搅拌均匀可得到本发明。
CN201810498443.6A 2018-05-23 2018-05-23 烧、烫伤用负离子壳聚糖复合喷剂及其制备方法 Pending CN108434332A (zh)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1382480A (zh) * 2002-05-15 2002-12-04 李高霖 治疗外伤用的无痕贴及其制备方法和用途

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1382480A (zh) * 2002-05-15 2002-12-04 李高霖 治疗外伤用的无痕贴及其制备方法和用途

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