CN108434129A - 用于联合治疗的药物组合物 - Google Patents
用于联合治疗的药物组合物 Download PDFInfo
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- CN108434129A CN108434129A CN201810575583.9A CN201810575583A CN108434129A CN 108434129 A CN108434129 A CN 108434129A CN 201810575583 A CN201810575583 A CN 201810575583A CN 108434129 A CN108434129 A CN 108434129A
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- suofenxin
- metoprolol
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- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000020830 overeating Nutrition 0.000 description 1
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- VLTRZXGMWDSKGL-UHFFFAOYSA-M perchlorate Inorganic materials [O-]Cl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-M 0.000 description 1
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000000902 placebo Substances 0.000 description 1
- 229940068196 placebo Drugs 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- IENZQIKPVFGBNW-UHFFFAOYSA-N prazosin Chemical compound N=1C(N)=C2C=C(OC)C(OC)=CC2=NC=1N(CC1)CCN1C(=O)C1=CC=CO1 IENZQIKPVFGBNW-UHFFFAOYSA-N 0.000 description 1
- 229960001289 prazosin Drugs 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 108700022737 rat Fat1 Proteins 0.000 description 1
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- 238000011084 recovery Methods 0.000 description 1
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- 229920005989 resin Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 238000012502 risk assessment Methods 0.000 description 1
- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 1
- 229960001860 salicylate Drugs 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 229940076279 serotonin Drugs 0.000 description 1
- 230000000697 serotonin reuptake Effects 0.000 description 1
- 230000036259 sexual stimuli Effects 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 229940075554 sorbate Drugs 0.000 description 1
- 238000012453 sprague-dawley rat model Methods 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 229940114926 stearate Drugs 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229940086735 succinate Drugs 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 230000008093 supporting effect Effects 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 230000002889 sympathetic effect Effects 0.000 description 1
- 230000001975 sympathomimetic effect Effects 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
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- 229940095064 tartrate Drugs 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 229950009970 tesofensine Drugs 0.000 description 1
- 150000004685 tetrahydrates Chemical class 0.000 description 1
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 1
- 108010050939 thrombocytin Chemical group 0.000 description 1
- 230000036962 time dependent Effects 0.000 description 1
- 229950004288 tosilate Drugs 0.000 description 1
- WBYWAXJHAXSJNI-VOTSOKGWSA-M trans-cinnamate Chemical compound [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- 150000004684 trihydrates Chemical class 0.000 description 1
- 239000003174 triple reuptake inhibitor Substances 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261599623P | 2012-02-16 | 2012-02-16 | |
| DKPA201270076 | 2012-02-16 | ||
| US61/599,623 | 2012-02-16 | ||
| DKPA201270076 | 2012-02-16 | ||
| CN201380020405.5A CN104244935A (zh) | 2012-02-16 | 2013-02-14 | 用于联合治疗的药物组合物 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380020405.5A Division CN104244935A (zh) | 2012-02-16 | 2013-02-14 | 用于联合治疗的药物组合物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108434129A true CN108434129A (zh) | 2018-08-24 |
Family
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Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810575583.9A Pending CN108434129A (zh) | 2012-02-16 | 2013-02-14 | 用于联合治疗的药物组合物 |
| CN201810580312.2A Pending CN108853071A (zh) | 2012-02-16 | 2013-02-14 | 用于联合治疗的药物组合物 |
| CN201380020405.5A Pending CN104244935A (zh) | 2012-02-16 | 2013-02-14 | 用于联合治疗的药物组合物 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810580312.2A Pending CN108853071A (zh) | 2012-02-16 | 2013-02-14 | 用于联合治疗的药物组合物 |
| CN201380020405.5A Pending CN104244935A (zh) | 2012-02-16 | 2013-02-14 | 用于联合治疗的药物组合物 |
Country Status (14)
| Country | Link |
|---|---|
| US (5) | US9211271B2 (OSRAM) |
| EP (1) | EP2814473B1 (OSRAM) |
| JP (1) | JP6203760B2 (OSRAM) |
| CN (3) | CN108434129A (OSRAM) |
| AU (1) | AU2013220424B2 (OSRAM) |
| CA (1) | CA2864264C (OSRAM) |
| DK (1) | DK2814473T3 (OSRAM) |
| EA (1) | EA029543B1 (OSRAM) |
| ES (1) | ES2704987T3 (OSRAM) |
| HR (1) | HRP20190050T1 (OSRAM) |
| LT (1) | LT2814473T (OSRAM) |
| PL (1) | PL2814473T3 (OSRAM) |
| SI (1) | SI2814473T1 (OSRAM) |
| WO (1) | WO2013120935A1 (OSRAM) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6203760B2 (ja) * | 2012-02-16 | 2017-09-27 | サニオナ・エー／エス | 併用療法のための医薬組成物 |
| EP3087798A4 (en) * | 2013-12-28 | 2017-08-30 | Intel Corporation | System and method for device action and configuration based on user context detection from sensors in peripheral devices |
| LT3265126T (lt) * | 2015-03-03 | 2021-09-10 | Saniona A/S | Tesofensino ir metoprololio derinio kompozicija |
| EP3402473A1 (en) | 2016-01-15 | 2018-11-21 | Saniona A/S | Tesofensine and metoprolol for treatment of hypertension |
| WO2018046599A1 (en) | 2016-09-07 | 2018-03-15 | Saniona A/S | Tesofensine compositions |
| US20220160658A1 (en) | 2019-01-07 | 2022-05-26 | Saniona A/S | Tesofensine for reduction of body weight in prader-willi patients |
| CN110297826B (zh) * | 2019-05-31 | 2020-12-11 | 南京理工大学 | 基于json动态解析卫星遥测数据的方法 |
| WO2021214233A1 (en) | 2020-04-22 | 2021-10-28 | Saniona A/S | Treatment of hypothalamic obesity |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992016197A1 (en) * | 1991-03-18 | 1992-10-01 | Sepracor Inc. | Composition and method containing optically pure (s) metoprolol |
| WO2009080693A2 (en) * | 2007-12-20 | 2009-07-02 | Neurosearch A/S | Pharmaceutical composition comprising tesofensine or its analogue and a beta blocker |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3238414B2 (ja) | 1996-02-22 | 2001-12-17 | ニューロサーチ・アクティーゼルスカブ | トロパン―誘導体、その製造方法及びその使用方法 |
| EP1727547A1 (en) | 2004-01-22 | 2006-12-06 | Neurosearch A/S | Compounds for the sustained reduction of body weight |
| WO2009065845A1 (en) | 2007-11-20 | 2009-05-28 | Neurosearch A/S | A method for treating over-eating disorders |
| EP2237781A2 (en) | 2007-12-20 | 2010-10-13 | NeuroSearch A/S | Pharmaceutical composition comprising tesofensine or its analogue and an anti-obesity |
| WO2011100659A2 (en) | 2010-02-12 | 2011-08-18 | Kitov Pharmaceutical Ltd. | Ameliorating drug-induced elevations in blood pressure by adjunctive use of antihypertensive drugs |
| JP6203760B2 (ja) * | 2012-02-16 | 2017-09-27 | サニオナ・エー／エス | 併用療法のための医薬組成物 |
| LT3265126T (lt) * | 2015-03-03 | 2021-09-10 | Saniona A/S | Tesofensino ir metoprololio derinio kompozicija |
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2013
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- 2013-02-14 WO PCT/EP2013/052941 patent/WO2013120935A1/en not_active Ceased
- 2013-02-14 HR HRP20190050TT patent/HRP20190050T1/hr unknown
- 2013-02-14 SI SI201331313T patent/SI2814473T1/sl unknown
- 2013-02-14 ES ES13703834T patent/ES2704987T3/es active Active
- 2013-02-14 AU AU2013220424A patent/AU2013220424B2/en not_active Ceased
- 2013-02-14 CA CA2864264A patent/CA2864264C/en active Active
- 2013-02-14 CN CN201810580312.2A patent/CN108853071A/zh active Pending
- 2013-02-14 CN CN201380020405.5A patent/CN104244935A/zh active Pending
- 2013-02-14 DK DK13703834.5T patent/DK2814473T3/en active
- 2013-02-14 EP EP13703834.5A patent/EP2814473B1/en active Active
- 2013-02-14 PL PL13703834T patent/PL2814473T3/pl unknown
- 2013-02-14 LT LTEP13703834.5T patent/LT2814473T/lt unknown
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2015
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2016
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2018
- 2018-02-27 US US15/906,350 patent/US20180185304A1/en not_active Abandoned
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2021
- 2021-07-27 US US17/386,098 patent/US20220016055A1/en not_active Abandoned
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992016197A1 (en) * | 1991-03-18 | 1992-10-01 | Sepracor Inc. | Composition and method containing optically pure (s) metoprolol |
| WO2009080693A2 (en) * | 2007-12-20 | 2009-07-02 | Neurosearch A/S | Pharmaceutical composition comprising tesofensine or its analogue and a beta blocker |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2814473A1 (en) | 2014-12-24 |
| US20160074344A1 (en) | 2016-03-17 |
| US20180185304A1 (en) | 2018-07-05 |
| PL2814473T3 (pl) | 2019-06-28 |
| HRP20190050T1 (hr) | 2019-03-08 |
| CN108853071A (zh) | 2018-11-23 |
| SI2814473T1 (sl) | 2019-03-29 |
| DK2814473T3 (en) | 2019-01-28 |
| CA2864264A1 (en) | 2013-08-22 |
| WO2013120935A1 (en) | 2013-08-22 |
| AU2013220424A1 (en) | 2014-09-25 |
| CA2864264C (en) | 2020-05-05 |
| JP6203760B2 (ja) | 2017-09-27 |
| CN104244935A (zh) | 2014-12-24 |
| US20170007557A1 (en) | 2017-01-12 |
| HK1204946A1 (en) | 2015-12-11 |
| AU2013220424B2 (en) | 2017-03-23 |
| US9211271B2 (en) | 2015-12-15 |
| EA201491532A1 (ru) | 2015-01-30 |
| US20150025107A1 (en) | 2015-01-22 |
| US20220016055A1 (en) | 2022-01-20 |
| JP2015508765A (ja) | 2015-03-23 |
| EP2814473B1 (en) | 2018-10-10 |
| EA029543B1 (ru) | 2018-04-30 |
| ES2704987T3 (es) | 2019-03-21 |
| US9387184B2 (en) | 2016-07-12 |
| LT2814473T (lt) | 2019-01-25 |
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