CN108421001A - A kind of Chinese medicine composition and preparation method thereof for treating myocarditis - Google Patents
A kind of Chinese medicine composition and preparation method thereof for treating myocarditis Download PDFInfo
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Abstract
The invention discloses a kind of Chinese medicine compositions and preparation method thereof for treating myocarditis.It is made of the substance of following parts by weight：30 80 parts of Radix Astragali, 40 70 parts of turmeric, 30 80 parts of curcuma zedoary, 20 50 parts of Rhizoma Atractylodis Macrocephalae, 10 30 parts of rhizoma anemarrhenae.The Chinese medicine composition for the treatment of myocarditis prepared by the present invention, there is good drug effect for myocarditis caused by a variety of causes, it has no toxic side effect, extracting method uses diacolation, refluxing extraction, ultrasonic wave extraction are applied in combination, while extracting active constituents of medicine to greatest extent, maintain the activity of active constituent so that drug effect performs to maximum.
Description
Technical field
The invention belongs to Cardiological technical fields, and in particular to a kind of Chinese medicine composition that treating myocarditis and its preparation side
Method.
Background technology
Myocarditis refers to the limitation of myocardium muscle layer or diffused inflammatory lesion caused by the various causes of disease.Inflammatory lesion
Cardiac muscle, interstitial, blood vessel, pericardium or the internal membrane of heart can be involved.Its cause of disease can be various infection, autoimmune response and physics and chemistry because
Element.The course of disease can be acute, subacute and chronic.In China, vital myocarditis is more typical.Clinical manifestation usually with it is impaired
The amount of sad flesh is related.The clinical manifestation of light-duty myocarditis is less, and diagnosis is more difficult, therefore pathological diagnosis is high more than clinical onset rate.
Patent 201010231844.9 discloses the Chinese medicine for the treatment of chronic myocarditis.Its active constituent is by following weight proportion
Raw material composition：3~9 parts of Rhizoma Chuanxiong, 3~9 parts of safflower, 9~15 parts of longan, 5~15 parts of Radix Salviae Miltiorrhizae, 9~15 parts of the seed of Oriental arborvitae, honey-fried licorice root
6~10 parts, 6~15 parts of the stem of noble dendrobium, 6~12 parts of Radix picrorrhizae, 1~3 part of rush, 4~10 parts of cape jasmine, 9~15 parts of Caulis Spatholobi, curcuma zedoary
3~9 parts, 3~9 parts of Radix Polygalae, 6~15 parts of Radix Codonopsis, 10~30 parts of purslane speedwell, 9~15 parts of mulberries, 6~10 parts of paper mulberry fruit.The Chinese medicine
Composition can only treat chronic myocarditis, invalid for acute myocarditis, and therapeutic effect slowly effect.
Patent 200910028883.6 discloses a kind of drug for treating myocarditis.By the raw material of following weight percents
It is made：Radix polygonati officinalis 5~15%, Ramulus euonymi 10~15%, lepidium seed 10~25%, fermented soya bean 5~20%, cornu bubali 5~15%, Radix Curcumae
5~25%, radix bupleuri 5~20%, Rhizoma Chuanxiong 5~20%.The traditional Chinese medicine composition for treating effect is poor, and has certain side reaction.
Patent 201510985345.1 discloses a kind of Chinese medicine for treating myocarditis.The Chinese medicine is by following portions by weight
Medicinal material is made：17-35 parts of honey-fried licorice root, 10-18 parts of the spot insect destructive of the roots of seedlings, 9-24 parts of Longtube Ground Ivy Herb, 10-26 parts of Radix Astragali, 5-17 parts of Wingedtooth Laggera Herb, even
Stick up 10-25 parts, 9-27 parts of Siberian fritillary bulb, 3-8 parts of great burdock achene, 3-9 parts of Lapis Micae Aureus, 11-18 parts of chingma abutilon seed, 6-20 parts of waxgourd peel, stone
11-19 parts of courage grass, 2-12 parts of tabasheer, 5-17 parts of rhizoma alismatis, 6-20 parts of the flower bud of lily magnolia, 12-25 parts of folium panacis japonici cum caule.The pharmaceutical compositions
Complexity has more side effect, preparation to be not easy, and recurrence is easy after healing.
Invention content
The purpose of the present invention is to provide a kind of Chinese medicine compositions and preparation method thereof for treating myocarditis.
A kind of Chinese medicine composition for treating myocarditis, is made of the substance of following parts by weight：30-80 parts of Radix Astragali, turmeric
40-70 parts, 30-80 parts of curcuma zedoary, 20-50 parts of Rhizoma Atractylodis Macrocephalae, 10-30 parts of rhizoma anemarrhenae.
The Chinese medicine composition further includes 30-50 parts of Lonicera Japonica passionflower (Passiflora biflora Lam.).
The Chinese medicine composition further includes 40-80 parts of phyllitis japonica.
The preparation method of the Chinese medicine composition of above-mentioned treatment myocarditis, carries out in accordance with the following steps：
(1) 30-80 parts of Radix Astragali is weighed, 40-70 parts of turmeric crushes, and crosses 40-60 mesh sieve, percolator is packed into, using 1-2 times
The ethanol solution of weight is swollen 1-2 hours, then 6-8 times of ethanol solution is added to carry out diacolation, and flow velocity 1-3mL/min obtains diacolation
Liquid；
(2) 30-80 parts of curcuma zedoary is weighed, 20-50 parts of Rhizoma Atractylodis Macrocephalae crushes, and crosses 40-60 mesh sieve, adds the water of 6-10 times of parts by weight
Refluxing extraction 3 times, merging filtrate obtain filtrate A；
(3) 10-30 parts of rhizoma anemarrhenae is weighed, is crushed, 60-80 mesh sieve is crossed, the 60-80% ethyl alcohol that 8-12 times of parts by weight are added is molten
Liquid, ultrasonic wave extraction 30-60min, filtering obtain liquor B；
(4) merge percolate, filtrate A, liquor B depressurizes low temperature and is evaporated the Chinese medicine composition that treatment mastitis is made.
The power of the ultrasonic wave extraction, ultrasonic wave is 200-400W.
The pressure that the decompression low temperature is evaporated is 10-15kPa, and temperature is 4-12 DEG C.
Preferably, 30-50 parts of refluxing extractions of Lonicera Japonica passionflower are additionally added in step (2).
Preferably, 40-80 parts of ultrasonic wave extractions of phyllitis japonica are additionally added in step (3).
Beneficial effects of the present invention：The Chinese medicine composition for the treatment of myocarditis prepared by the present invention, causes a variety of causes
Myocarditis have good drug effect, have no toxic side effect, extracting method use diacolation, refluxing extraction, the combination of ultrasonic wave extraction
It uses, while extracting active constituents of medicine to greatest extent, maintains the activity of active constituent so that drug effect performs to most
Greatly.
Specific implementation mode
With reference to specific embodiment, the present invention will be further described.
Embodiment 1
A kind of Chinese medicine composition for treating myocarditis, is made of the substance of following parts by weight：Radix Astragali 50g, turmeric 50g,
Curcuma zedoary 60g, Rhizoma Atractylodis Macrocephalae 30g, rhizoma anemarrhenae 20g.
The preparation method of the Chinese medicine composition of above-mentioned treatment myocarditis, carries out in accordance with the following steps：
(1) Radix Astragali 50g, turmeric 50g are weighed, is crushed, 50 mesh sieve is crossed, is packed into percolator, the ethyl alcohol using 1.5 times of weight is molten
Liquid is swollen 1.5 hours, then 7 times of ethanol solution is added to carry out diacolation, and flow velocity 2mL/min obtains percolate；
(2) curcuma zedoary 60g, Rhizoma Atractylodis Macrocephalae 30g are weighed, is crushed, 50 mesh sieve is crossed, adds the water refluxing extraction 3 times of 8 times of parts by weight, close
And filtrate, obtain filtrate A；
(3) rhizoma anemarrhenae 20g is weighed, is crushed, 70 mesh sieve is crossed, 70% ethanol solution of 10 times of parts by weight is added, ultrasonic wave carries
50min is taken, the power of ultrasonic wave is 300W, and filtering obtains liquor B；
(4) merge percolate, filtrate A, liquor B depressurizes low temperature and is evaporated the Chinese medicine composition that treatment mastitis is made；It is described
The pressure that decompression low temperature is evaporated is 12kPa, and temperature is 8 DEG C.
Embodiment 2
A kind of Chinese medicine composition for treating myocarditis, is made of the substance of following parts by weight：Radix Astragali 30g, turmeric 40g,
Curcuma zedoary 30g, Rhizoma Atractylodis Macrocephalae 20g, rhizoma anemarrhenae 10g.
The preparation method of the Chinese medicine composition of above-mentioned treatment myocarditis, carries out in accordance with the following steps：
(1) Radix Astragali 30g, turmeric 40g are weighed, is crushed, 40 mesh sieve is crossed, percolator is packed into, using the ethanol solution of 1 times of weight
Swelling 1 hour, then 6 times of ethanol solution is added to carry out diacolation, flow velocity 1mL/min obtains percolate；
(2) curcuma zedoary 30g, Rhizoma Atractylodis Macrocephalae 20g are weighed, is crushed, 40 mesh sieve is crossed, adds the water refluxing extraction 3 times of 6 times of parts by weight, close
And filtrate, obtain filtrate A；
(3) rhizoma anemarrhenae 10g is weighed, is crushed, 60 mesh sieve is crossed, 60% ethanol solution of 8 times of parts by weight, ultrasonic wave extraction is added
The power of 30min, ultrasonic wave are 200W, and filtering obtains liquor B；
(4) merge percolate, filtrate A, liquor B depressurizes low temperature and is evaporated the Chinese medicine composition that treatment mastitis is made；It is described
The pressure that decompression low temperature is evaporated is 10kPa, and temperature is 4 DEG C.
Embodiment 3
A kind of Chinese medicine composition for treating myocarditis, is made of the substance of following parts by weight：Radix Astragali 80g, turmeric 70g,
Curcuma zedoary 80g, Rhizoma Atractylodis Macrocephalae 50g, rhizoma anemarrhenae 30g.
The preparation method of the Chinese medicine composition of above-mentioned treatment myocarditis, carries out in accordance with the following steps：
(1) Radix Astragali 80g, turmeric 70g are weighed, is crushed, 60 mesh sieve is crossed, percolator is packed into, using the ethanol solution of 2 times of weight
Swelling 2 hours, then 8 times of ethanol solution is added to carry out diacolation, flow velocity 3mL/min obtains percolate；
(2) curcuma zedoary 80g, Rhizoma Atractylodis Macrocephalae 50g are weighed, is crushed, 60 mesh sieve is crossed, adds the water refluxing extraction 3 times of 10 times of parts by weight, close
And filtrate, obtain filtrate A；
(3) rhizoma anemarrhenae 30g is weighed, is crushed, 80 mesh sieve is crossed, 80% ethanol solution of 12 times of parts by weight is added, ultrasonic wave carries
60min is taken, the power of ultrasonic wave is 400W, and filtering obtains liquor B；
(4) merge percolate, filtrate A, liquor B depressurizes low temperature and is evaporated the Chinese medicine composition that treatment mastitis is made；It is described
The pressure that decompression low temperature is evaporated is 15kPa, and temperature is 12 DEG C.
Embodiment 4
A kind of Chinese medicine composition for treating myocarditis, is made of the substance of following parts by weight：Radix Astragali 50g, turmeric 50g,
Curcuma zedoary 60g, Rhizoma Atractylodis Macrocephalae 30g, rhizoma anemarrhenae 20g, Lonicera Japonica passionflower 40g.
The preparation method of the Chinese medicine composition of above-mentioned treatment myocarditis, carries out in accordance with the following steps：
(1) Radix Astragali 50g, turmeric 50g are weighed, is crushed, 50 mesh sieve is crossed, is packed into percolator, the ethyl alcohol using 1.5 times of weight is molten
Liquid is swollen 1.5 hours, then 7 times of ethanol solution is added to carry out diacolation, and flow velocity 2mL/min obtains percolate；
(2) curcuma zedoary 60g, Rhizoma Atractylodis Macrocephalae 30g, Lonicera Japonica passionflower 40g are weighed, is crushed, 50 mesh sieve is crossed, adds the water of 8 times of parts by weight
Refluxing extraction 3 times, merging filtrate obtain filtrate A；
(3) rhizoma anemarrhenae 20g is weighed, is crushed, 70 mesh sieve is crossed, 70% ethanol solution of 10 times of parts by weight is added, ultrasonic wave carries
50min is taken, the power of ultrasonic wave is 300W, and filtering obtains liquor B；
(4) merge percolate, filtrate A, liquor B depressurizes low temperature and is evaporated the Chinese medicine composition that treatment mastitis is made；It is described
The pressure that decompression low temperature is evaporated is 12kPa, and temperature is 8 DEG C.
Embodiment 5
A kind of Chinese medicine composition for treating myocarditis, is made of the substance of following parts by weight：Radix Astragali 50g, turmeric 50g,
Curcuma zedoary 60g, Rhizoma Atractylodis Macrocephalae 30g, rhizoma anemarrhenae 20g, the moon leaf passionflower (Passiflora altebilobata Hemsl.) 40g.
The preparation method of the Chinese medicine composition of above-mentioned treatment myocarditis, carries out in accordance with the following steps：
(1) Radix Astragali 50g, turmeric 50g are weighed, is crushed, 50 mesh sieve is crossed, is packed into percolator, the ethyl alcohol using 1.5 times of weight is molten
Liquid is swollen 1.5 hours, then 7 times of ethanol solution is added to carry out diacolation, and flow velocity 2mL/min obtains percolate；
(2) curcuma zedoary 60g, Rhizoma Atractylodis Macrocephalae 30g are weighed, is crushed moon leaf passionflower 40g, 50 mesh sieve is crossed, adds the water of 8 times of parts by weight
Refluxing extraction 3 times, merging filtrate obtain filtrate A；
(3) rhizoma anemarrhenae 20g is weighed, is crushed, 70 mesh sieve is crossed, 70% ethanol solution of 10 times of parts by weight is added, ultrasonic wave carries
50min is taken, the power of ultrasonic wave is 300W, and filtering obtains liquor B；
(4) merge percolate, filtrate A, liquor B depressurizes low temperature and is evaporated the Chinese medicine composition that treatment mastitis is made；It is described
The pressure that decompression low temperature is evaporated is 12kPa, and temperature is 8 DEG C.
Embodiment 6
A kind of Chinese medicine composition for treating myocarditis, is made of the substance of following parts by weight：Radix Astragali 50g, turmeric 50g,
Curcuma zedoary 60g, Rhizoma Atractylodis Macrocephalae 30g, rhizoma anemarrhenae 20g, phyllitis japonica 60g.
The preparation method of the Chinese medicine composition of above-mentioned treatment myocarditis, carries out in accordance with the following steps：
(1) Radix Astragali 50g, turmeric 50g, phyllitis japonica 60g are weighed, is crushed, 50 mesh sieve is crossed, percolator is packed into, using 1.5 times of weights
The ethanol solution of amount is swollen 1.5 hours, then the ethanol solution of 7 times of weight is added to carry out diacolation, and flow velocity 2mL/min obtains percolate；
(2) curcuma zedoary 60g, Rhizoma Atractylodis Macrocephalae 30g are weighed, is crushed, 50 mesh sieve is crossed, adds the water refluxing extraction 3 times of 8 times of parts by weight, close
And filtrate, obtain filtrate A；
(3) rhizoma anemarrhenae 20g is weighed, is crushed, 70 mesh sieve is crossed, 70% ethanol solution of 10 times of parts by weight is added, ultrasonic wave carries
50min is taken, the power of ultrasonic wave is 300W, and filtering obtains liquor B；
(4) merge percolate, filtrate A, liquor B depressurizes low temperature and is evaporated the Chinese medicine composition that treatment mastitis is made；It is described
The pressure that decompression low temperature is evaporated is 12kPa, and temperature is 8 DEG C.
Embodiment 7
A kind of Chinese medicine composition for treating myocarditis, is made of the substance of following parts by weight：Radix Astragali 50g, turmeric 50g,
Curcuma zedoary 60g, Rhizoma Atractylodis Macrocephalae 30g, rhizoma anemarrhenae 20g, umbrella tree 60g.
The preparation method of the Chinese medicine composition of above-mentioned treatment myocarditis, carries out in accordance with the following steps：
(1) Radix Astragali 50g, turmeric 50g, umbrella tree 60g are weighed, is crushed, 50 mesh sieve is crossed, percolator is packed into, using 1.5 times
The ethanol solution of weight is swollen 1.5 hours, then the ethanol solution of 7 times of weight is added to carry out diacolation, and flow velocity 2mL/min obtains diacolation
Liquid；
(2) curcuma zedoary 60g, Rhizoma Atractylodis Macrocephalae 30g are weighed, is crushed, 50 mesh sieve is crossed, adds the water refluxing extraction 3 times of 8 times of parts by weight, close
And filtrate, obtain filtrate A；
(3) rhizoma anemarrhenae 20g is weighed, is crushed, 70 mesh sieve is crossed, 70% ethanol solution of 10 times of parts by weight is added, ultrasonic wave carries
50min is taken, the power of ultrasonic wave is 300W, and filtering obtains liquor B；
(4) merge percolate, filtrate A, liquor B depressurizes low temperature and is evaporated the Chinese medicine composition that treatment mastitis is made；It is described
The pressure that decompression low temperature is evaporated is 12kPa, and temperature is 8 DEG C.
Experimental example：
The BALB/c mouse of the healthy male 4-6 week old of selection provides between average weight reaches 13-15g and meets experimental animal
Use the diet and water source of standard.It uses through being injected intraperitoneally with CVB3Method infecting mouse, build VMC models.Experiment mice
Intraperitoneal injection 0.1mL includes 1X102TCID50CVB3Eagle ' s liquid.The pharmaceutical composition of embodiment 1-7 is fed, 5mg/g is held
Continuous medication 10d, control group feed drinking water, observe the Survival of mouse, and hair color, activity condition and diet are drunk water situation,
The mortality of mouse in the period is recorded, the death rate is counted.
Mortality results are shown in Table 1：
Table 1
Note：* P is represented<0.05；* represents P<0.01.
As can be seen from Table 1, the mouse death rate of embodiment 1-7 is significantly lower than control group, it was demonstrated that medicine group of the invention
Closing object there is good therapeutic effect, embodiment 4, embodiment 6 and embodiment 7 to have reached extremely significant vital myocarditis
Difference (P<0.01), effect is better than embodiment 1, and embodiment 5 is suitable with embodiment 1.
Experimental example 2：
Case 1：Mr. Wang, female 49 years old, suffer from myocarditis more than 2 years, uncomfortable in chest, dizzy, and increased heart rate is will produce when serious, use
Several method treatment is crossed, takes 1 drug therapy of the embodiment of the present invention, daily 3g, after taking 2 months, symptom mitigates, and takes 4
After month, symptom disappears, recovery from illness.
Case 2：Lin, man, 36 years old, uncomfortable in chest, weak, shortness of breath, the symptoms such as spontaneous perspiration.Heart sound is low blunt, and arteries and veins is thin and delicate, and tongue nature is light,
It is diagnosed as myocarditis；The drug of the present invention is taken after 7 days, 4 drug therapy of the embodiment of the present invention, daily 3g, after taking 3 months,
Symptom disappears, recovery from illness.
Case 3：Lee, female, 33 years old, patient's myocarditis 3 years had the symptoms such as uncomfortable in chest, weak, shortness of breath, syncope, spontaneous perspiration, hair
44 beats/min of heart rate when sick, heart sound is low blunt, and electrocardio ST-T changes, and arteries and veins is thin and delicate, and tongue nature is light, while there is indentation to add ecchymosis.Take this hair
The drug of bright embodiment 7, daily 3g, after taking 1 month, above-mentioned symptom is clearly better, and continues to take 3 months, above-mentioned symptom disappears
It loses, physical recovery is normal.
Claims (8)
1. a kind of Chinese medicine composition for treating myocarditis, which is characterized in that be made of the substance of following parts by weight：Radix Astragali 30-
80 parts, 40-70 parts of turmeric, 30-80 parts of curcuma zedoary, 20-50 parts of Rhizoma Atractylodis Macrocephalae, 10-30 parts of rhizoma anemarrhenae.
2. a kind of Chinese medicine composition for treating myocarditis according to claim 1, which is characterized in that the Chinese medicine composition is also
Including 30-50 parts of Lonicera Japonica passionflower.
3. a kind of Chinese medicine composition for treating myocarditis according to claim 1, which is characterized in that the Chinese medicine composition is also
Including 40-80 parts of phyllitis japonica.
4. described in claim 1 treat myocarditis Chinese medicine composition preparation method, which is characterized in that in accordance with the following steps into
Row：
(1) 30-80 parts of Radix Astragali is weighed, 40-70 parts of turmeric crushes, and crosses 40-60 mesh sieve, percolator is packed into, using 1-2 times of weight
Ethanol solution be swollen 1-2 hour, then add 6-8 times of ethanol solution progress diacolation, flow velocity 1-3mL/min obtains percolate；
(2) 30-80 parts of curcuma zedoary is weighed, 20-50 parts of Rhizoma Atractylodis Macrocephalae crushes, and crosses 40-60 mesh sieve, adds the water reflux of 6-10 times of parts by weight
Extraction 3 times, merging filtrate obtains filtrate A；
(3) 10-30 parts of rhizoma anemarrhenae is weighed, is crushed, 60-80 mesh sieve is crossed, the 60-80% ethanol solutions of 8-12 times of parts by weight is added,
Ultrasonic wave extraction 30-60min, filtering, obtains liquor B；
(4) merge percolate, filtrate A, liquor B depressurizes low temperature and is evaporated the Chinese medicine composition that treatment mastitis is made.
5. the preparation method of the Chinese medicine composition for the treatment of myocarditis according to claim 1, which is characterized in that the ultrasonic wave
The power of extraction, ultrasonic wave is 200-400W.
6. the preparation method of the Chinese medicine composition for the treatment of myocarditis according to claim 1, which is characterized in that the decompression is low
The pressure that temperature is evaporated is 10-15kPa, and temperature is 4-12 DEG C.
7. the preparation method of the Chinese medicine composition for the treatment of myocarditis according to claim 1, which is characterized in that in step (2)
It is additionally added 30-50 parts of refluxing extractions of Lonicera Japonica passionflower.
8. the preparation method of the Chinese medicine composition for the treatment of myocarditis according to claim 1, which is characterized in that in step (3)
It is additionally added 40-80 parts of ultrasonic wave extractions of phyllitis japonica.
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| CN104127680A (en) * | 2014-08-01 | 2014-11-05 | 范广慈 | Traditional Chinese medicine formula for treating myocarditis |
| CN105362797A (en) * | 2015-12-25 | 2016-03-02 | 赵红 | Traditional Chinese medicine for treating myocarditis |
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| CN105362797A (en) * | 2015-12-25 | 2016-03-02 | 赵红 | Traditional Chinese medicine for treating myocarditis |
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