CN108420997A - 一种治疗羔羊痢疾的中药组合物 - Google Patents
一种治疗羔羊痢疾的中药组合物 Download PDFInfo
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Abstract
本发明涉及一组治疗羔羊痢疾的中药组合物，属于兽医技术领域。本发明涉及一种治疗羔羊痢疾的中药复合物，该中药复合物各组分的重量份数组成为：白头翁6～10份，郁金6～10份，秦皮6～10份，黄连6～10份，黄柏8～12份，贯众8～12份，地榆8～12份，槐花10～15份，苍术6～10份，甘草6～10份。本发明所选择药物白头翁、秦皮、黄连、黄柏、贯众、地榆均具有清热解毒之功效，白头翁、秦皮、黄连、黄柏、苍术均具有燥湿止痢之功效，白头翁、郁金、地榆、槐花均具有凉血止血之功效，复合物各组方药物之间协同作用明显，组合用药后，清热解毒、凉血止血、燥湿止痢、解痉止痛作用更为明显。
Description
技术领域
本发明涉及一种治疗羔羊痢疾的中药组合物，属于兽医技术领域。
背景技术
羔羊痢疾是影响羔羊成活率和生长发育的一种常见病，是由B型魏氏梭菌引起的初生羔羊的一种急性毒血症，以剧烈腹泻、小肠发生溃疡和羔羊发生大批死亡为特征；病羊为主要的传染源，本病主要危害7d以内羔羊，2～3d发病最多，7d以上少发，且纯种细毛羊的发病率和死亡率最高；患羊主要表现为剧烈腹泻、溃疡性肠炎及出血性肠炎等。由于不同条件和因素的影响，发病率和死亡率均较高，对养羊业造成严重的危害。
目前对于羔羊痢疾的预防和治疗，主要采用抗生素进行预防和治疗，如土霉素、痢特灵、磺胺类药物等，长期使用或滥用抗生素，容易引起机体免疫功能下降，破坏胃肠道菌群平衡，损害肠道健康，影响营养的吸收，严重威胁养羊业的可持续发展；导致细菌产生耐药性和羊肉及其制品中的抗生素残留严重超标，影响羊群疫病防控、羊肉制品安全和出口等，人们长期食用有抗生素残留的羊肉制品，易引起人过敏反应、毒性反应等，危害人们的身体健康。所以，越来越多的抗生素禁止用于羊病治疗。综上所述，当前急需一种高效、廉价、易用、无残留、无耐药和抗菌的一种药物预防和治疗羔羊痢疾。
由于中药来源天然，低残留或无残留，不易产生耐药性，具有抗菌抗病毒、清除肠道毒素和消除炎症等作用，对人体无害，引起了人们对中药广泛的研究，致力于将中药用于防治羔羊痢疾，促进无公害养羊。所以迫切需要研制一种疗效显著、稳定，且毒副作用小、价廉实用的中药制剂治疗羔羊痢疾。
目前已有中药治疗羔羊痢疾的文章和中药组合物专利申请，如《用于治疗羔羊痢疾的重要组合物》（公开号CN 105287819 A）、《一种防治羔羊痢疾的组合物及其应用》（公开号CN 104000049 A）、《一种治疗羔羊痢疾的中药组合物及其制备方法》（公开号CN104147190 A）。但是，本专利申请的中药组方与已报道的完全不同，能有效防治羔羊痢疾，具有很好的应用前景。
发明内容
本发明的目的是要提供一种高效、价廉、易用、无残留或低残留、无耐药和无副作用的药物治疗羔羊痢疾，用中药替代抗生素药物治疗羔羊痢疾，保证羔羊肠道健康，促进羔羊快速生长。
一种治疗羔羊痢疾的中药组合物，重量份数组成为：白头翁6～10份，郁金6～10份，秦皮6～10份，黄连6～10份，黄柏8～12份，贯众8～12份，地榆8～12份，槐花10～15份，苍术6～10份，甘草6～10份。
在一个实施例中，重量份数组成为：白头翁8份，郁金8份，秦皮8份，黄连8份，黄柏10份，贯众10份，地榆10份，槐花12份，苍术8份，甘草8份。
治疗羔羊痢疾的中药组合物的制备方法，包括如下步骤：
将各组分混合后，粉碎，加入各组分总质量10～12倍的水，在冷水中浸泡20～25min；煎至药液为总量十分之一左右；进行过滤，去渣取汁。
治疗羔羊痢疾的中药组合物在制备用于治疗羔羊痢疾药剂中的用途。
所述的药剂，是散剂、丸剂、片剂、草药汤剂、胶囊制剂或口服液制剂。
本发明选择白头翁、郁金、秦皮、黄连、黄柏、贯众、地榆、槐花、苍术、甘草10味中药，利用中草药相生相克的原则，将这些药物进行组合，药物之间产生协同作用，达到清热解毒、凉血止痢、燥湿收敛的功效。其中白头翁味苦，性寒，具有清热解毒、凉血止痢、燥湿杀虫之功效；郁金味辛苦，性寒，具有活血止疼、行气解郁、清心凉血、疏肝利胆的作用，还具有调节免疫力、改善血液循环、抗自由基损伤的功效；秦皮味苦涩，性寒，具有清热燥湿、收涩止痢的功效；黄连性味苦、寒，具有清热泻火、燥湿解毒等功效；黄柏性寒、味苦，具清热燥湿、泻火解毒等功效；贯众性微寒、味苦，具有清热解毒、利水渗湿的功效；地榆性寒、味苦酸，具有凉血止血、清热解毒、消肿敛疮的功效；槐花味苦、性微寒，具有凉血止血、清肝泻火的功效；苍术性温、味辛苦，具有燥湿健脾、祛风除湿的功效，还可降低细菌耐药性的产生；甘草性平、味甘，具有解毒、祛痰、止痛、解痉、抗癌等功效。
本发明所选择药物白头翁、秦皮、黄连、黄柏、贯众、地榆均具有清热解毒之功效，白头翁、秦皮、黄连、黄柏、苍术均具有燥湿止痢之功效，白头翁、郁金、地榆、槐花均具有凉血止血之功效，复合物各组方药物之间协同作用明显，组合用药后，清热解毒、凉血止血、燥湿止痢、解痉止痛作用更为明显。
具体实施方式
实施例1
按重量份，将白头翁8份，郁金8份，秦皮8份，黄连8份，黄柏10份，贯众10份，地榆10份，槐花12份，苍术8份，甘草8份。所述组分按照配比混合均匀后碾碎，每剂中药饮片的长度不超过3.5cm，置于煎药容器，加入原药总质量11倍的水，在冷水中浸泡20min；用猛火煎至沸腾，至药液总量一半左右再以文火煎煮，至药液为总量十分之一左右时灭火；进行过滤，去渣取汁，即得该中药复合物汤剂。
实施例2
按重量份，将白头翁6份，郁金10份，秦皮6份，黄连10份，黄柏8份，贯众12份，地榆8份，槐花15份，苍术6份，甘草10份。所述组分按照配比混合均匀后碾碎，每剂中药饮片的长度不超过3.5cm，置于煎药容器，加入原药总质量10倍的水，在冷水中浸泡25min；用猛火煎至沸腾，至药液总量一半左右再以文火煎煮，至药液为总量十分之一左右时灭火；进行过滤，去渣取汁，即得该中药复合物汤剂。
实施例3
按重量份，将白头翁10份，郁金6份，秦皮10份，黄连6份，黄柏12份，贯众8份，地榆12份，槐花10份，苍术10份，甘草6份。所述组分按照配比混合均匀后碾碎，每剂中药饮片的长度不超过3.5cm，置于煎药容器，加入原药总质量12倍的水，在冷水中浸泡20min；用猛火煎至沸腾，至药液总量一半左右再以文火煎煮，至药液为总量十分之一左右时灭火；进行过滤，去渣取汁，即得该中药复合物汤剂。
对照例1
与实施例1的区别是：未在药物中加入地榆。
按重量份，将白头翁8份，郁金8份，秦皮8份，黄连8份，黄柏10份，贯众10份，槐花12份，苍术8份，甘草8份。所述组分按照配比混合均匀后碾碎，每剂中药饮片的长度不超过3.5cm，置于煎药容器，加入原药总质量11倍的水，在冷水中浸泡20min；用猛火煎至沸腾，至药液总量一半左右再以文火煎煮，至药液为总量十分之一左右时灭火；进行过滤，去渣取汁，即得该中药复合物汤剂。
对照例2
与实施例1的区别是：未在药物中加入秦皮。
按重量份，将白头翁8份，郁金8份，黄连8份，黄柏10份，贯众10份，地榆10份，槐花12份，苍术8份，甘草8份。所述组分按照配比混合均匀后碾碎，每剂中药饮片的长度不超过3.5cm，置于煎药容器，加入原药总质量11倍的水，在冷水中浸泡20min；用猛火煎至沸腾，至药液总量一半左右再以文火煎煮，至药液为总量十分之一左右时灭火；进行过滤，去渣取汁，即得该中药复合物汤剂。
对照例3
采用CN 104147190A中实施例3的药物作为对照。
选取360只患有羔羊痢疾的羔羊，采用以上实施例1-3、对照例1-2中的药剂，每日早晚各灌服40mL 1次，连用5日。用药期间不使用其他药物，正常饲养管理。
另外，对照例3采用CN 104147190A中的给药方法，每只羔羊每次5mg,每天2次，2天为1个疗程。
以上各实验组，每组60只羔羊，痢疾疗效判定：治愈：其肛门红肿发热、尾部下痢明显、食欲下降等临床症状完全消失；有效：其临床症状基本消失或明显好转；无效：其临床症状继续恶化。
各组的治愈情况如下表所示：
| 实施例1 | 实施例2 | 实施例3 | 对照例1 | 对照例2 | 对照例3 | |
| 治愈 | 86.67% | 85.00% | 90.00% | 80.00% | 78.33% | 86.67% |
| 有效 | 96.67% | 95.00% | 98.33% | 81.67% | 83.33% | 95.00% |
| 无效 | 3.33% | 5.00% | 1.67% | 18.33% | 16.67% | 5.00% |
从上表中可以看到，本发明提供的药物组合物可以有效地对羔羊痢疾进行治疗，其治疗效果优于现有技术水平的药物。其中，实施例3相对于对照例1来说，由于通过地榆凉血止血之功效与白头翁、秦皮的清热解毒之功效相辅，有效地提高了治愈效果；而实施例3相对于对照例2来说，通过秦皮燥湿止痢之功效，也能够有效地提高治愈率。
Claims (5)
1.一种治疗羔羊痢疾的中药组合物，其特征在于，重量份数组成为：白头翁6～10份，郁金6～10份，秦皮6～10份，黄连6～10份，黄柏8～12份，贯众8～12份，地榆8～12份，槐花10～15份，苍术6～10份，甘草6～10份。
2.根据权利要求1所述的治疗羔羊痢疾的中药组合物，其特征在于，重量份数组成为：白头翁8份，郁金8份，秦皮8份，黄连8份，黄柏10份，贯众10份，地榆10份，槐花12份，苍术8份，甘草8份。
3.权利要求1所述的治疗羔羊痢疾的中药组合物的制备方法，其特征在于，包括如下步骤：将各组分混合后，粉碎，加入各组分总质量10～12倍的水，在冷水中浸泡20～25min；煎至药液为总量十分之一左右；进行过滤，去渣取汁。
4.权利要求1所述的治疗羔羊痢疾的中药组合物在制备用于治疗羔羊痢疾药剂中的用途。
5.根据权利要求4所述的用途，其特征在于，所述的药剂，是散剂、丸剂、片剂、草药汤剂、胶囊制剂或口服液制剂作为药剂形式。
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