CN108420930A - Chinese medicine composition and its preparation method and application for treating rheumatism - Google Patents

Chinese medicine composition and its preparation method and application for treating rheumatism Download PDF

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Publication number
CN108420930A
CN108420930A CN201810456438.9A CN201810456438A CN108420930A CN 108420930 A CN108420930 A CN 108420930A CN 201810456438 A CN201810456438 A CN 201810456438A CN 108420930 A CN108420930 A CN 108420930A
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parts
chinese medicine
medicine composition
chinese
rheumatism
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幸永明
潘胜果
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Chongqing Yuelong Biological Pharmaceutical Co Ltd
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Chongqing Yuelong Biological Pharmaceutical Co Ltd
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/258—Panax (ginseng)
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    • A61K33/00—Medicinal preparations containing inorganic active ingredients
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Abstract

The present invention relates to a kind of Chinese medicine compositions and its preparation method and application for treating rheumatism, and the composition includes the following raw material：Radix Notoginseng, Radix Angelicae Pubescentis, arisacma consanguineum schott, rhizoma dioscoreae nipponicae, Cortex Eucommiae, long-nosed pit viper, safflower, cortex acanthopanacis, radix cyathulae, clerodendron trichotomum, Chinese ephedra, Herba Epimedii, berba aristolochiae mollissimae, rhizoma atractylodis, full worm, sweet wormwood fruit, the root of Chinese clematis, turpentine, dragon's blood, water orchid leaf, datura flower, native copper, Herba Achilleae and raw two crow.The present invention for treating the Chinese medicine composition of rheumatism, each bulk pharmaceutical chemicals synergistic effect play it is clearing heat and detoxicating, expel endogenous wind to relieve convulsion, relieve pain, have the effect of promoting blood circulation and removing blood stasis, row network of promoting blood circulation, its good effect, quick, treating both manifestation and root cause of disease, it has no toxic side effect, there is good commercial promise.

Description

Chinese medicine composition and its preparation method and application for treating rheumatism
Technical field
The invention belongs to technical field of traditional Chinese medicines, more particularly to a kind of Chinese medicine composition and its preparation side for treating rheumatism Method and application.
Background technology
Rheumatism is one group of infringement joint, bone, muscle, blood vessel and in relation to the disease based on soft tissue or connective tissue, Wherein most is autoimmune disease.Morbidity it is much more hidden and slow, be common clinical, frequently-occurring disease, disease cycle compared with Long, clinical symptoms performance is various, and disease is obstinate, and treatment phase is longer；Because such disease cause of disease, the interpretation of the cause, onset and process of an illness are more complicated, clinic is in more Marginality, multidisciplinary performance, the disunity of the limitation of traditional Chinese medicine itself and the understanding to such disease, is debated to clinic in addition Card treats and brings certain difficulty to the clinical research work of such lesion.
Invention content
An object of the present invention is to provide a kind of Chinese medicine compositions for treating rheumatism.
The Chinese medicine composition for treating rheumatism of the present invention, includes the raw material of following parts by weight：Radix Notoginseng 30 parts~45 Part, 20 parts~30 parts of Radix Angelicae Pubescentis, 20 parts~30 parts of arisacma consanguineum schott, 40 parts~60 parts of rhizoma dioscoreae nipponicae, 30 parts~40 parts of Cortex Eucommiae, 20 parts of long-nosed pit viper~ 25 parts, 10 parts~20 parts of safflower, 20 parts~30 parts of cortex acanthopanacis, 30 parts~40 parts of radix cyathulae, 20 parts~30 parts of clerodendron trichotomum, Chinese ephedra 20 Part~40 parts, 25 parts~35 parts of Herba Epimedii, 10 parts~20 parts of berba aristolochiae mollissimae, 20 parts~30 parts of rhizoma atractylodis, 10 parts~20 parts of full worm, sweet wormwood Son 25 parts~30 parts, 15 parts~25 parts of the root of Chinese clematis, 20 parts~30 parts of turpentine, 10 parts~25 parts of dragon's blood, 25 parts~30 parts of water orchid leaf, 10 parts~20 parts of datura flower, 5 parts~10 parts of native copper, 10 parts~20 parts of Herba Achilleae and raw two 20 parts~30 parts of crow.
The Chinese medicine composition for treating rheumatism of the present invention, each bulk pharmaceutical chemicals synergistic effect play clearing heat and detoxicating, wind-dispelling solution Convulsion relieves pain, and has the effect of promoting blood circulation and removing blood stasis, row network of promoting blood circulation, and good effect is quick, and treating both manifestation and root cause of disease has no toxic side effect, With good commercial promise.
In addition, the Chinese medicine composition for treating rheumatism that the present invention is above-mentioned, can also have following additional technology special Sign：
As the preferred embodiment of the present invention, the Chinese medicine composition for treating rheumatism, including following weight The raw material of number：30 parts of Radix Notoginseng, 30 parts of Radix Angelicae Pubescentis, 20 parts of arisacma consanguineum schott, 60 parts of rhizoma dioscoreae nipponicae, 30 parts of Cortex Eucommiae, 25 parts of long-nosed pit viper, safflower 10 Part, 30 parts of cortex acanthopanacis, 30 parts of radix cyathulae, 30 parts of clerodendron trichotomum, 20 parts of Chinese ephedra, 35 parts of Herba Epimedii, 10 parts of berba aristolochiae mollissimae, 30 parts of rhizoma atractylodis, Complete 10 parts of worm, 30 parts of sweet wormwood fruit, 15 parts of the root of Chinese clematis, 30 parts of turpentine, 10 parts of dragon's blood, 25 parts of water orchid leaf, 10 parts of datura flower, native copper 10 parts, 10 parts of Herba Achilleae and raw two 30 parts of crow.
As the preferred embodiment of the present invention, the Chinese medicine composition for treating rheumatism, including following weight The raw material of number：45 parts of Radix Notoginseng, 20 parts of Radix Angelicae Pubescentis, 30 parts of arisacma consanguineum schott, 40 parts of rhizoma dioscoreae nipponicae, 40 parts of Cortex Eucommiae, 20 parts of long-nosed pit viper, safflower 20 Part, 20 parts of cortex acanthopanacis, 40 parts of radix cyathulae, 20 parts of clerodendron trichotomum, 40 parts of Chinese ephedra, 25 parts of Herba Epimedii, 20 parts of berba aristolochiae mollissimae, 20 parts of rhizoma atractylodis, Complete 20 parts of worm, 25 parts of sweet wormwood fruit, 25 parts of the root of Chinese clematis, 20 parts of turpentine, 25 parts of dragon's blood, 30 parts of water orchid leaf, 20 parts of datura flower, native copper 5 parts, 20 parts of Herba Achilleae and raw two 20 parts of crow.
As the preferred embodiment of the present invention, the Chinese medicine composition for treating rheumatism, including following weight The raw material of number：37 parts of Radix Notoginseng, 25 parts of Radix Angelicae Pubescentis, 25 parts of arisacma consanguineum schott, 50 parts of rhizoma dioscoreae nipponicae, 35 parts of Cortex Eucommiae, 23 parts of long-nosed pit viper, safflower 15 Part, 25 parts of cortex acanthopanacis, 35 parts of radix cyathulae, 25 parts of clerodendron trichotomum, 30 parts of Chinese ephedra, 30 parts of Herba Epimedii, 15 parts of berba aristolochiae mollissimae, 25 parts of rhizoma atractylodis, Complete 15 parts of worm, 27 parts of sweet wormwood fruit, 20 parts of the root of Chinese clematis, 25 parts of turpentine, 17 parts of dragon's blood, 27 parts of water orchid leaf, 15 parts of datura flower, native copper 7 parts, 15 parts of Herba Achilleae and raw two 25 parts of crow.
It is another object of the present invention to the preparation method for proposing the Chinese medicine composition for treating rheumatism, packets Include following steps：By the raw material stoving, disinfection, the water of 2 times~4 times its weight then is added and big fire is heated to boiling, 10min~20min is kept the temperature, 2h~4h is then boiled by slow fire, refilters and collect filtrate, obtain the Chinese medicine group for treating rheumatism Close object.
Further, in filtering, the aperture of the strainer is 1 μm~100 μm.
Further, in drying, drying temperature is 60 DEG C~80 DEG C, and drying time is 30min~60min.
Another object of the present invention is to propose the method in preparing the Chinese medicine composition for treating rheumatism Application.
The additional aspect and advantage of the present invention will be set forth in part in the description, and will partly become from the following description Obviously, or practice through the invention is recognized.
Specific implementation mode
The embodiment of the present invention is described below in detail, the embodiment is exemplary, it is intended to for explaining the present invention, and It is not considered as limiting the invention.
Experimental method in following embodiments is unless otherwise specified conventional method.
Test material as used in the following examples is unless otherwise specified to be commercially available from conventional reagent shop.
Radix Notoginseng as used in the following examples, Radix Angelicae Pubescentis, arisacma consanguineum schott, rhizoma dioscoreae nipponicae, Cortex Eucommiae, long-nosed pit viper, safflower, cortex acanthopanacis, river ox Knee, clerodendron trichotomum, Chinese ephedra, Herba Epimedii, berba aristolochiae mollissimae, rhizoma atractylodis, full worm, sweet wormwood fruit, the root of Chinese clematis, turpentine, dragon's blood, water orchid leaf, datura flower, Native copper, Herba Achilleae and raw two crow meet the pertinent regulations under each medicinal material item of text of Chinese Pharmacopoeia (version in 2015).It throws Before material, by identification, ingredients material object is consistent with title, and quality complies with standard.
Embodiment 1
Embodiment 1 proposes a kind of Chinese medicine composition for treating rheumatism, includes the raw material of following parts by weight：Radix Notoginseng 30 parts, 30 parts of Radix Angelicae Pubescentis, 20 parts of arisacma consanguineum schott, 60 parts of rhizoma dioscoreae nipponicae, 30 parts of Cortex Eucommiae, 25 parts of long-nosed pit viper, 10 parts of safflower, 30 parts of cortex acanthopanacis, river 30 parts of the root of bidentate achyranthes, 30 parts of clerodendron trichotomum, 20 parts of Chinese ephedra, 35 parts of Herba Epimedii, 10 parts of berba aristolochiae mollissimae, 30 parts of rhizoma atractylodis, 10 parts of full worm, sweet wormwood fruit 30 Part, 15 parts of the root of Chinese clematis, 30 parts of turpentine, 10 parts of dragon's blood, 25 parts of water orchid leaf, 10 parts of datura flower, 10 parts of native copper, 10 parts of Herba Achilleae and Raw two 30 parts of crow.
The preparation method of the Chinese medicine composition for treating rheumatism of embodiment 1, includes the following steps：First by the original 60min being dried at a temperature of 60 DEG C after material mixing and being sterilized, the water of 2 times of its weight then is added and big fire is heated to boiling, 10min is kept the temperature, 4h is then boiled by slow fire, refilters and collect filtrate, obtain the Chinese medicine composition for treating rheumatism.Wherein, In filtering, the aperture of the strainer is 1 μm.
Embodiment 2
Embodiment 2 proposes a kind of Chinese medicine composition for treating rheumatism, includes the raw material of following parts by weight：Radix Notoginseng 45 parts, 20 parts of Radix Angelicae Pubescentis, 30 parts of arisacma consanguineum schott, 40 parts of rhizoma dioscoreae nipponicae, 40 parts of Cortex Eucommiae, 20 parts of long-nosed pit viper, 20 parts of safflower, 20 parts of cortex acanthopanacis, river 40 parts of the root of bidentate achyranthes, 20 parts of clerodendron trichotomum, 40 parts of Chinese ephedra, 25 parts of Herba Epimedii, 20 parts of berba aristolochiae mollissimae, 20 parts of rhizoma atractylodis, 20 parts of full worm, sweet wormwood fruit 25 Part, 25 parts of the root of Chinese clematis, 20 parts of turpentine, 25 parts of dragon's blood, 30 parts of water orchid leaf, 20 parts of datura flower, 5 parts of native copper, 20 parts of Herba Achilleae and Raw two 20 parts of crow.
The preparation method of the Chinese medicine composition for treating rheumatism of embodiment 2, includes the following steps：First by the original 30min being dried at a temperature of 80 DEG C after material mixing and being sterilized, the water of 4 times of its weight then is added and big fire is heated to boiling, 20min is kept the temperature, 2h is then boiled by slow fire, refilters and collect filtrate, obtain the Chinese medicine composition for treating rheumatism.Wherein, In filtering, the aperture of the strainer is 100 μm.
Embodiment 3
Embodiment 3 proposes a kind of Chinese medicine composition for treating rheumatism, includes the raw material of following parts by weight：Radix Notoginseng 37 parts, 25 parts of Radix Angelicae Pubescentis, 25 parts of arisacma consanguineum schott, 50 parts of rhizoma dioscoreae nipponicae, 35 parts of Cortex Eucommiae, 23 parts of long-nosed pit viper, 15 parts of safflower, 25 parts of cortex acanthopanacis, river 35 parts of the root of bidentate achyranthes, 25 parts of clerodendron trichotomum, 30 parts of Chinese ephedra, 30 parts of Herba Epimedii, 15 parts of berba aristolochiae mollissimae, 25 parts of rhizoma atractylodis, 15 parts of full worm, sweet wormwood fruit 27 Part, 20 parts of the root of Chinese clematis, 25 parts of turpentine, 17 parts of dragon's blood, 27 parts of water orchid leaf, 15 parts of datura flower, 7 parts of native copper, 15 parts of Herba Achilleae and Raw two 25 parts of crow.
The preparation method of the Chinese medicine composition for treating rheumatism of embodiment 3, includes the following steps：First by the original 45min being dried at a temperature of 70 DEG C after material mixing and being sterilized, the water of 3 times of its weight then is added and big fire is heated to boiling, 15min is kept the temperature, 3h is then boiled by slow fire, refilters and collect filtrate, obtain the Chinese medicine composition for treating rheumatism.Wherein, In filtering, the aperture of the strainer is 50 μm.
Toxicity test
It is 18~22 parts, small white mouse 300 (each 150 of male and female) to select weight, is divided into 3 groups, each 25 of every group of male and female are small White mouse back unhairing exposes exocuticle, and unhairing range 2cm × 2cm smears the embodiment of the present invention 1 to embodiment 3 and is prepared into respectively The Chinese medicine composition arrived, dosage are 0.5 part, successive administration 30 days.When during administration and 1 week after being discontinued, observation white mouse life Long status and activity and diet, identification hematology, blood biochemical analysis, organ tissue structure and routine urinalysis etc..As a result, it has been found that all Small white mouse health existence, it is without any side effects；Blood picture, liver function, each organs and tissues state is dissected and observed, with normal little Bai Mouse compares indifference.It is demonstrated experimentally that Chinese medicine composition provided by the invention is nontoxic, drug safety is reliable.
To sum up, the Chinese medicine composition for treating rheumatism of the invention, each bulk pharmaceutical chemicals synergistic effect play it is clearing heat and detoxicating, dispel Wind spasmolysis relieves pain, and has the effect of promoting blood circulation and removing blood stasis, row network of promoting blood circulation, and good effect is quick, treating both manifestation and root cause of disease, nontoxic secondary work With with good commercial promise.
In the description of this specification, reference term " one embodiment ", " some embodiments ", " example ", " specifically show The description of example " or " some examples " etc. means specific features, structure, material or spy described in conjunction with this embodiment or example Point is included at least one embodiment or example of the invention.In the present specification, schematic expression of the above terms are not It must be directed to identical embodiment or example.Moreover, particular features, structures, materials, or characteristics described can be in office It can be combined in any suitable manner in one or more embodiments or example.In addition, without conflicting with each other, the skill of this field Art personnel can tie the feature of different embodiments or examples described in this specification and different embodiments or examples It closes and combines.
Although the embodiments of the present invention has been shown and described above, it is to be understood that above-described embodiment is example Property, it is not considered as limiting the invention, those skilled in the art within the scope of the invention can be to above-mentioned Embodiment is changed, changes, replacing and modification.

Claims (8)

1. a kind of Chinese medicine composition for treating rheumatism, which is characterized in that include the raw material of following parts by weight：30 parts of Radix Notoginseng ~45 parts, 20 parts~30 parts of Radix Angelicae Pubescentis, 20 parts~30 parts of arisacma consanguineum schott, 40 parts~60 parts of rhizoma dioscoreae nipponicae, 30 parts~40 parts of Cortex Eucommiae, long-nosed pit viper 20 Part~25 parts, 10 parts~20 parts of safflower, 20 parts~30 parts of cortex acanthopanacis, 30 parts~40 parts of radix cyathulae, 20 parts~30 parts of clerodendron trichotomum, fiber crops Yellow 20 parts~40 parts, 25 parts~35 parts of Herba Epimedii, 10 parts~20 parts of berba aristolochiae mollissimae, 20 parts~30 parts of rhizoma atractylodis, 10 parts~20 parts of full worm, 25 parts~30 parts of sweet wormwood fruit, 15 parts~25 parts of the root of Chinese clematis, 20 parts~30 parts of turpentine, 10 parts~25 parts of dragon's blood, 25 parts of water orchid leaf~ 30 parts, 10 parts~20 parts of datura flower, 5 parts~10 parts of native copper, 10 parts~20 parts of Herba Achilleae and raw two 20 parts~30 parts of crow.
2. the Chinese medicine composition according to claim 1 for treating rheumatism, which is characterized in that including following parts by weight Raw material：30 parts of Radix Notoginseng, 30 parts of Radix Angelicae Pubescentis, 20 parts of arisacma consanguineum schott, 60 parts of rhizoma dioscoreae nipponicae, 30 parts of Cortex Eucommiae, 25 parts of long-nosed pit viper, 10 parts of safflower, five Add 30 parts of skin, 30 parts of radix cyathulae, 30 parts of clerodendron trichotomum, 20 parts of Chinese ephedra, 35 parts of Herba Epimedii, 10 parts of berba aristolochiae mollissimae, 30 parts of rhizoma atractylodis, full worm 10 Part, 30 parts of sweet wormwood fruit, 15 parts of the root of Chinese clematis, 30 parts of turpentine, 10 parts of dragon's blood, 25 parts of water orchid leaf, 10 parts of datura flower, 10 parts of native copper, 10 parts of Herba Achilleae and raw two 30 parts of crow.
3. the Chinese medicine composition according to claim 1 for treating rheumatism, which is characterized in that including following parts by weight Raw material：45 parts of Radix Notoginseng, 20 parts of Radix Angelicae Pubescentis, 30 parts of arisacma consanguineum schott, 40 parts of rhizoma dioscoreae nipponicae, 40 parts of Cortex Eucommiae, 20 parts of long-nosed pit viper, 20 parts of safflower, five Add 20 parts of skin, 40 parts of radix cyathulae, 20 parts of clerodendron trichotomum, 40 parts of Chinese ephedra, 25 parts of Herba Epimedii, 20 parts of berba aristolochiae mollissimae, 20 parts of rhizoma atractylodis, full worm 20 Part, 25 parts of sweet wormwood fruit, 25 parts of the root of Chinese clematis, 20 parts of turpentine, 25 parts of dragon's blood, 30 parts of water orchid leaf, 20 parts of datura flower, 5 parts of native copper, one 20 parts of branch wormwood artemisia and raw two 20 parts of crow.
4. the Chinese medicine composition according to claim 1 for treating rheumatism, which is characterized in that including following parts by weight Raw material：37 parts of Radix Notoginseng, 25 parts of Radix Angelicae Pubescentis, 25 parts of arisacma consanguineum schott, 50 parts of rhizoma dioscoreae nipponicae, 35 parts of Cortex Eucommiae, 23 parts of long-nosed pit viper, 15 parts of safflower, five Add 25 parts of skin, 35 parts of radix cyathulae, 25 parts of clerodendron trichotomum, 30 parts of Chinese ephedra, 30 parts of Herba Epimedii, 15 parts of berba aristolochiae mollissimae, 25 parts of rhizoma atractylodis, full worm 15 Part, 27 parts of sweet wormwood fruit, 20 parts of the root of Chinese clematis, 25 parts of turpentine, 17 parts of dragon's blood, 27 parts of water orchid leaf, 15 parts of datura flower, 7 parts of native copper, one 15 parts of branch wormwood artemisia and raw two 25 parts of crow.
5. preparing the method that claim 1-4 any one of them is used to treat the Chinese medicine composition of rheumatism, which is characterized in that packet Include following steps：By the raw material stoving, disinfection, the water of 2 times~4 times its weight then is added and big fire is heated to boiling, 10min~20min is kept the temperature, 2h~4h is then boiled by slow fire, refilters and collect filtrate, obtain the Chinese medicine group for treating rheumatism Close object.
6. the preparation method according to claim 5 for treating the Chinese medicine composition of rheumatism, which is characterized in that filtering When, the aperture of the strainer is 1 μm~100 μm.
7. the preparation method according to claim 5 for treating the Chinese medicine composition of rheumatism, which is characterized in that drying When, drying temperature is 60 DEG C~80 DEG C, and drying time is 30min~60min.
8. application of the claim 5-7 any one of them method in preparing the Chinese medicine composition for treating rheumatism.
CN201810456438.9A 2018-05-14 2018-05-14 Chinese medicine composition and its preparation method and application for treating rheumatism Pending CN108420930A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1371699A (en) * 2001-02-28 2002-10-02 刘军 Chinese medicine liquid for treating rheumatism and preparation method thereof
CN103948768A (en) * 2014-03-28 2014-07-30 房显增 Traditional Chinese medicine preparation for treating rheumatism and rheumatoid arthritis

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1371699A (en) * 2001-02-28 2002-10-02 刘军 Chinese medicine liquid for treating rheumatism and preparation method thereof
CN103948768A (en) * 2014-03-28 2014-07-30 房显增 Traditional Chinese medicine preparation for treating rheumatism and rheumatoid arthritis

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