CN1069044C - Injection for AIDs and preparation thereof - Google Patents
Injection for AIDs and preparation thereof Download PDFInfo
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- CN1069044C CN1069044C CN 97119121 CN97119121A CN1069044C CN 1069044 C CN1069044 C CN 1069044C CN 97119121 CN97119121 CN 97119121 CN 97119121 A CN97119121 A CN 97119121A CN 1069044 C CN1069044 C CN 1069044C
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- aids
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Abstract
The present invention relates to an injection and a preparation method for treating AIDS, which adopts a unique cause removing principle of treatment for warming the channel, cooling blood, removing filth, eliminating turbidity and expelling toxin for disengaging from pleurodiaphragmatic in terspace; effective components of traditional Chinese medicine are analyzed after good curative effect are obtained according to scientific point of view of modern medicine; various goals which can enter are proposed according to different stages of AIDS virus replicative cycles; a specific formula is selected from natural plants, etc., effective components which can directly enter blood circulation systems to treat AIDS are extracted, and the injection is prepared. The present invention has significant curative effect on clinic AIDS of each period.
Description
The present invention relates to a kind of treatment pre-AIDS (Pre-AIDS), chronic lymphatic is tied disease syndrome (Chronic Lymphadenopathy Syndrome, CLS), AIDS related complex (AIDS-related complex, ARC), the injection of " perfect form " acquired immune deficiency syndrome (AIDS) acquired immune deficiency syndrome (AIDS) such as (Fullblown acquired Immuodeficiency Syndrome), specifically main is the injection of feedstock production with the natural plants, the invention still further relates to the preparation method of this medicine.
At present, also not at the ideal treatment method of HIV (human immunodeficiency virus), existing medicine is many because of aspect reasons such as toxic and side effects are too big, virus drug resistance increases day by day, medical expense is high, can not satisfy social needs.The active ingredient of seeking high-efficiency low-toxicity from natural plants has been trend of the times, and fully discovery and arrangement traditional medicine treasure-house, screen the related drugs footpath effectively on foot of can yet be regarded as according to the theory of its uniqueness.
At present the Chinese medicine acquired immune deficiency syndrome (AIDS) many according to patients clinical dialectical and adopt respectively set upright get rid of evils, heavy dose of heat-clearing and toxic substances removing, nourishing YIN and clearing away heat and air making-up and spleen enlivening, blood circulation promoting and blood stasis dispelling, clearing away heat from YING and blood systems, waking up the patient from unconsciousness by dissipating phlegm etc. are executed the Therapeutic Principle who controls with card, though certain curative effect is arranged, square medicine is various, difficult branch primary and secondary, use inconvenience, the curative effect repeatability is relatively poor.
The object of the present invention is to provide a kind of injection of the high-efficiency low-toxicity that from materials such as natural plants, extracts, be used for the treatment of acquired immune deficiency syndrome (AIDS).
The present invention is from traditional medical theory, it is because YIN YANG toxin syndrome (HIV (human immunodeficiency virus)) epidemic pathogenic factor is overstepped the authority into pleurodiaphragmatic in terspace (immune system) that system proposes acquired immune deficiency syndrome (AIDS), watch the machine of human body loss dissipation, the cloudy passages through which vital energy circulates that coagulates, poison consumes vital essence and causes the heating of the expectorant stasis of blood, consumption impairment of YIN Tianjin, the absurd row of forcing blood, the many deteriorated cases of unconsciousness and collapse etc. " incubative pathogen nine passes ", it is " YIN YANG interdislocation syndrome " disease of typical " at first feeling frustrated; blood trouble then; hinder meat; muscle and tendon injury; the injury of the bone ", adopt unique warming the meridian removing heat from blood, it is turbid to ward off dirtyization, the removing because of the rule of treatment of " fast from pleurodiaphragmatic in terspace " heals, select traditional medicine in view of the above for use, after 3 aids patients are obtained better therapeutic effect, again according to modern medicine science viewpoint, effective ingredient in the analysis conventional medicine prescription, different phase at the HIV (human immunodeficiency virus) replicative cycle, the all types of target that antiviral agent can be got involved is proposed, comprise and stop combining of virus and cd4 cell, the fusion of blocking virus and target cell membrane, suppress viral RNA and be transcribed into DNA, stop the integration of DNA and the expression of viral gene, suppress the generation and the assembling of virus protein, the blastogenesis of viral interference etc. may have different functional groups, from materials such as natural plants, choose special formulation, adopt merceration, distinct methods such as alcohol extraction extract a kind of active princlple that can directly enter blood circulation treatment acquired immune deficiency syndrome (AIDS) respectively.In Shenyang, the clinical research on ground such as Beijing, Sichuan, Bangkok shows, and is remarkable to (plant, type) AIDS curative effect of clinical each phase, and do not see obvious toxic-side effects, easy to use, repeatable higher, performance is better than other anti-AIDS drug commonly used.
Base stock of the present invention and prescription are:
1, the perennial machaka Paeonia suffruticosa of Ranunculaceae of excavating the 3-5 that grown autumn
Paeonia Suffruticosa Andr rhizome is removed fibrous root and stem Seedling, cleans earth,
Cut open and get root bark, dry.Take by weighing 100-200g (Tongling, Anhui Paeonia ostii is the best in quality);
2, divide summer and autumn and pluck 2 years blue Isatis of this plant of SHENGCAO pine of Cruciferae for 2-3 time
The Folium Isatidis of Indigotica Fort is removed impurity, dries.Take by weighing 100-200g;
3, Papaveraceae of gathering summer and autumn 1 year or biennial short and small herbaceous plant Herba corydalis edulis (Bu Shi Herba corydalis edulis)
The herb of Corydalis Bungeana Turcz..Or Violaceae herbaceos perennial purple
The whole herb with root of flower Herba Violae Viola Yedoensis Makino is cleaned and is dried.Take by weighing
200-300g；
4, pluck Berberidaceae herbaceos perennial Herba Epimedii E.Koreanum. summer and autumn
The aerial parts of Nakai dries, and removes thick stalk and impurity.Take by weighing 100-200g;
5, spring Compositae herbaceos perennial BINHAO Artemisia Scoparia Waldst.et
During the high 6-10cm of the seedling of Kit, pluck its aerial parts, dry, remove old
Stem, root and impurity.Take by weighing 50-150g;
6, pluck the cephaloid of feverfew Herba Dendranthematis indici Chtysanthemum Indicum L. autumn
Preface is dried.Take by weighing 100-200g
7, pluck Dryopteridaceae plant dryopteris crassirhizoma (dryopteris crassirhizoma) Droyoptevis autumn
The band petiole base rhizome of Crassirhizoma Nakai, the petiole of pruning, root hair shine
Do.Take by weighing 100-200g
8, summer is when Labiatae herbaceos perennial Spica Prunellae Prunella Vulgaris L. band
The fruit ear of flower is brownish red half to be adopted down when withered, and well sifted spare and impurity dry.Take by weighing 100-
200g
9, spring and autumn is excavated Stemonaceae plant Radix Stemonae Stemona Sessilifolia (Mig.)
The tuber of Franch.et.Sav is removed root hair, cleans, and puts boiling water and slightly scalds or steam to not having white
The heart takes out, and dries.Take by weighing 100-200g
10, winter and spring is when Palmae aiphyllium plant Semen Arecae Areca Cathecu L. fruit
Pluck when ripe, peel off peel, dry, section.Take by weighing 50-150g
11, summer, labiate Herba Leonuri Leonurus Heterophyllus Sweet stem and leaf was luxuriant
Contain, Hua Weikai or tap aerial parts when just opening dries.Take by weighing 200-300g
12,5% glucose injection Glucose (Dextrose) 2500ml.
13, inosine (inosine) Inosine (Hypoxanthosine Riboside HXR)
500ml。
Its preparation flow is:
1, the 1-8 raw material is cleaned, is pulverized, and stirs after the Burdick lamp sterilization, add from
12 liters of sub-pure water, 12 liters of immersions of 95% ethanol, with hydrochloric acid with above-mentioned soak
PH value be transferred to 2, soak at room temperature is more than 25 days.Medicinal residues are filtered, obtain acid pure water
Extract, the reuse sodium hydroxide is transferred to 8 with its pH value, leave standstill 24 hours after, obtain inclined to one side alkali
Property alcohol water extract, filter twice with the middling speed qualitative filter paper again after, send concentration tank to steam the slide method with room temperature
Reclaim ethanol and get concentrated solution standby;
2, the 9-11 raw material is cleaned, is pulverized, and stirs after the Burdick lamp sterilization, adds 3 public affairs
Rise 75% ethanol and mix well, soak more than 25 days.Medicinal residues are filtered, and it is standby to obtain alcohol extract;
3, with the 1st step gained concentrated solution in 40-50 degree temperature Celsius and the technetium alcohol extraction of the 2nd step institute
Medicinal liquid mixes, and adds 12 liter of 95% ethanol simultaneously, leave standstill 24 hours after, again with middling speed
After qualitative filter paper filters twice, send concentration tank thoroughly to reclaim ethanol and also must concentrate with room temperature steaming slide method
Liquid refilters the back bottling, adopts 45 minutes autoclavings of 120 degree then, leaves standstill 35 days
More than, as seen precipitate is arranged, refilter standby;
4, the 3rd step gained medicinal liquid is mixed with the 12-13 raw material mix well after, with sheet frame, G6
After each filtration once of density ultrafilter membrane, be sub-packed in 10 bottles, and adopt conventional intravenous fluid
After method for disinfection and sterilization sterilization, clarity lamp inspection are qualified finished product.
One active ingredient of injection of the present invention detects through the inactivating AIDS poison that China Preventive Medicial Science Institute's acquired immune deficiency syndrome (AIDS) research and inspection center carry out and shows: after the dilution in 1: 10 of its content, HIV-1 type HIV (human immunodeficiency virus) is had deactivation.And MT-4 cell well-grown is without any side effects.This injection through institute for drug control, Liaoning Province, Thailand Ministry of Public Health fragrant plant watt admires that clinical new drug inspection center and detects, safety examinations such as its haemolysis, pyrogen, allergy, acute and chronic toxicity test, teratogenesis, carcinogenic and content of beary metal are qualified fully.In addition through the Mycology Lab check of clinical first hospital of Chinese Medical Sciences University: the contained active ingredient of this injection has funguses such as the common opportunistic infection source of disease of aids patient such as Candida albicans, trichophyton, sporidiole bacterias to be killed and inhibitory action.
Embodiment one: be used for the treatment of pre-AIDS (Pre-AIDS):
1, the perennial machaka Paeonia suffruticosa of Ranunculaceae of excavating the 3-5 that grown autumn
Paeonia Suffruticosa Andr rhizome is removed fibrous root and stem Seedling, cleans earth,
Cut open and get root bark, dry.Take by weighing 120g.(Tongling, Anhui Paeonia ostii is the best in quality)
2, divide summer and autumn and pluck 2 years blue Isatis of this plant of SHENGCAO pine of Cruciferae for 2-3 time
The Folium Isatidis of Indigotica Fort is removed impurity, dries.Take by weighing 150g.
3, Papaveraceae of gathering summer and autumn 1 year or biennial short and small herbaceous plant Herba corydalis edulis (Bu Shi Herba corydalis edulis)
The herb of Corydalis Bungeana Turcz..Or the Violaceae herbaceos perennial is pale reddish brown
The whole herb with root of Herba Violae Viola Yedoensis Makino is cleaned and is dried.Take by weighing 300
g。
4, pluck Berberidaceae herbaceos perennial Herba Epimedii E.Koreanum. summer and autumn
The aerial parts of Nakai dries, and removes thick stalk and impurity.Take by weighing 150g.
5, spring Compositae herbaceos perennial BINHAO Artemisia Scoparia Waldst.et
During the high 6-10cm of the seedling of Kit, pluck its aerial parts, dry, remove old stem,
Root and impurity.Take by weighing 150g.
6, pluck the cephaloid of feverfew Herba Dendranthematis indici Chtysanthemum Indicum L. autumn
Preface is dried.Take by weighing 150g.
7, pluck Dryopteridaceae plant dryopteris crassirhizoma (dryopteris crassirhizoma) Droyoptevis autumn
The band petiole base rhizome of Crassirhizoma Nakai, the petiole of pruning, root hair dry.
Take by weighing 100g.
8, summer is when Labiatae herbaceos perennial Spica Prunellae Prunella Vulgaris L. band
The fruit ear of flower is brownish red half to be adopted down when withered, and well sifted spare and impurity dry.Take by weighing 150
g。
9, spring and autumn is excavated Stemonaceae plant Radix Stemonae Stemona Sessilifolia (Mig.)
The tuber of Franch.et.Sav is removed root hair, cleans, and puts boiling water and slightly scalds or steam to not having white
The heart takes out, and dries.Take by weighing 100g.10, winter and spring is when Palmae aiphyllium plant Semen Arecae Areca Cathecu L. fruit
Pluck when ripe, peel off peel, dry, section.Take by weighing 50g.11, summer, labiate Herba Leonuri Leonurus Heterophyllus Sweet stem and leaf was luxuriant
Contain, Hua Weikai or tap aerial parts when just opening dries.Take by weighing 300g.12,5% glucose injection Glucose (Dextrose) 2500ml.13, inosine (inosine) Inosine (Hypoxanthosine Riboside HXR)
500ml。Its preparation flow is:
1, the 1-8 raw material is cleaned, is pulverized, and stirs after the Burdick lamp sterilization, adds pure (going
Ion) water is 12 liters, 12 liters of immersions of 95% ethanol, with hydrochloric acid with above-mentioned soak
PH value be transferred to 2, soak at room temperature is more than 25 days.Medicinal residues are filtered, obtain acid pure water
Extract, the reuse sodium hydroxide is transferred to 8 with its pH value, leave standstill 24 hours after, obtain inclined to one side alkali
Property alcohol water extract, filter twice with the middling speed qualitative filter paper again after, send concentration tank to steam the slide method with room temperature
Reclaim ethanol and get concentrated solution standby.
2, the 9-11 raw material is cleaned, is pulverized, and stirs after the Burdick lamp sterilization, adds 3 public affairs
Rise 75% ethanol and mix well, soak more than 25 days.Medicinal residues are filtered, and it is standby to obtain alcohol extract.
3, with the 1st step gained concentrated solution 40-50 degree temperature Celsius and the 2nd step institute pure medicine
Liquid mixes, and adds 12 liter of 95% ethanol simultaneously, and as seen flocculoreaction is arranged, and leaves standstill 24 little
The time after, filter twice with the middling speed qualitative filter paper again after, send concentration tank to steam the slide method and thoroughly return with room temperature
Receive ethanol and get concentrated solution, refilter the back bottling, adopt 45 minutes high pressure of 120 degree to go out then
Bacterium was left standstill more than 35 days, and as seen precipitate is arranged, and refiltered standby.
4, with the 3rd step gained medicinal liquid mix with the 12-13 raw material mix well after, with sheet frame G6
After each filtration once of density ultrafilter membrane, be sub-packed in 10 bottles, and adopt conventional intravenous fluid
After method for disinfection and sterilization sterilization, clarity lamp inspection are qualified finished product.
This medicine is an intravenous fluid, consumption: one bottle of every day.Embodiment two: (AIDS-related complex, ARC) prescription and preparation method and embodiment are together to be used for the treatment of AIDS related complex.This injection consumption: each once a day two bottles.Embodiment three, be used for the treatment of " perfect form " acquired immune deficiency syndrome (AIDS) (Fullblown acquired Immuode ficiencySyndrome): prescription and preparation method and embodiment are together.This injection consumption: each once a day three bottles.
Claims (2)
1, a kind of injection for the treatment of acquired immune deficiency syndrome (AIDS) is characterized in that it is the perennial machaka Paeonia suffruticosa of injection (1) the Ranunculaceae rhizome of being made by the following weight proportion raw material, 100-200g; (2) 2 years blue Folium Isatidis of this plant of SHENGCAO pine of Cruciferae, 100-200g; (3) the whole herb with root 200-300g of herb of the short and small herbaceous plant Herba corydalis edulis of Papaveraceae and Violaceae herbaceos perennial Herba Violae; (4) the aerial parts 100-200g of Berberidaceae herbaceos perennial Herba Epimedii; (5) the seedling aerial parts 50-150g of Compositae herbaceos perennial BINHAO; (6) the head inflorescence 100-200g of feverfew Herba Dendranthematis indici; (7) the band petiole base rhizome 100-200g of Dryopteridaceae plant dryopteris crassirhizoma; (8) the wounded in the battle fruit ear 100-200g of Labiatae herbaceos perennial Spica Prunellae; (9) the tuber 100-200g of Stemonaceae plant Radix Stemonae; (10) Palmae aiphyllium plant Semen Arecae kernel 50-150g; (11) labiate aerial parts of Herba Leonuri 200-300g; (12) 5% glucose injection 2500ml; (13) inosine 500ml.
2, according to the preparation method of the injection of the described treatment acquired immune deficiency syndrome (AIDS) of claim 1, it is characterized in that: 1. (1)-(8) number raw material is cleaned, pulverized, stir after the Burdick lamp sterilization, add 12 liters of deionization pure water, 12 liters of immersions of 95% ethanol, with hydrochloric acid the pH value of above-mentioned soak is transferred to 2, soak at room temperature is more than 25 days.Medicinal residues are filtered, obtain acid pure water extract, the reuse sodium hydroxide is transferred to 8 with its pH value, leave standstill 24 hours after, obtain meta-alkalescence alcohol water extract, filters twice after, send concentration tank to steam the slide method and reclaim ethanol and get concentrated solution standby with room temperature; 2. (9)-(11) number raw material is cleaned, pulverized, stir after the Burdick lamp sterilization, add 3 liter of 75% ethanol and mix well, soak more than 25 days.Medicinal residues are filtered, and it is standby to obtain alcohol extract; 3. with 1. step gained concentrated solution 40-50 degree temperature Celsius with 2. step gained medicinal liquid mix, add 12 liter of 95% ethanol simultaneously, left standstill 24 hours, after filtering twice with the middling speed qualitative filter paper again, send concentration tank to steam the slide method and thoroughly reclaim ethanol and get concentrated solution, refilter the back bottling with room temperature, adopt 45 minutes autoclavings of 120 degree then, leave standstill more than 35 days, as seen precipitate is arranged, refilter standby; 4. with the 3. step gained medicinal liquid mix with (12)-(13) number raw material and mix well, after each filters once with sheet frame, G6 density ultrafilter membrane, be sub-packed in 10 bottles, and after adopting conventional intravenous fluid method for disinfection and sterilization sterilization, clarity lamp inspection qualified finished product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 97119121 CN1069044C (en) | 1997-10-10 | 1997-10-10 | Injection for AIDs and preparation thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 97119121 CN1069044C (en) | 1997-10-10 | 1997-10-10 | Injection for AIDs and preparation thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1178121A CN1178121A (en) | 1998-04-08 |
| CN1069044C true CN1069044C (en) | 2001-08-01 |
Family
ID=5175205
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 97119121 Expired - Fee Related CN1069044C (en) | 1997-10-10 | 1997-10-10 | Injection for AIDs and preparation thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1069044C (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101411796B (en) * | 2008-12-05 | 2011-09-07 | 中国热带农业科学院热带生物技术研究所 | Novel use of betelnut and extract thereof in preparing anti-AIDS medicament |
| CN105085537B (en) * | 2015-06-19 | 2017-10-27 | 中山职业技术学院 | A kind of isoindoles compound and its preparation method and application |
| CN105708896A (en) * | 2016-04-05 | 2016-06-29 | 黄群德 | Traditional Chinese medicine preparation for treating AIDS (acquired immune deficiency syndrome) |
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1997
- 1997-10-10 CN CN 97119121 patent/CN1069044C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1178121A (en) | 1998-04-08 |
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Owner name: BEIJING LUOMENG CHUANGYE BIOTECHNOLOGY DEVELOPMEN Free format text: FORMER OWNER: LUO MENG Effective date: 20040407 |
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Effective date of registration: 20040407 Address after: 100013 room 16, building 607, seven District, Dongcheng District, Beijing, Hepingli Patentee after: Beijing LuoMeng PioneeFive Ring Biological Technology Development Co., Ltd. Address before: 100054, 3, rose garden, Huandao Island, Fengtai District, Beijing, Yuquanying Patentee before: Luo Meng |
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