CN1084194C - Method for preparing ultramicro infant essence - Google Patents

Method for preparing ultramicro infant essence Download PDF

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Publication number
CN1084194C
CN1084194C CN98111876A CN98111876A CN1084194C CN 1084194 C CN1084194 C CN 1084194C CN 98111876 A CN98111876 A CN 98111876A CN 98111876 A CN98111876 A CN 98111876A CN 1084194 C CN1084194 C CN 1084194C
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CN
China
Prior art keywords
mixing
micronizing
granulate
dried particles
amount
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CN98111876A
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Chinese (zh)
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CN1227748A (en
Inventor
徐祖砚
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chongqing Yuyi Pharmaceutic Industry Co ltd
Sunflower Medicine Industry Group Chongqing Co ltd
Original Assignee
Three Nine Zitonggong Pharmaceutical Co ltd Sichuan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Three Nine Zitonggong Pharmaceutical Co ltd Sichuan filed Critical Three Nine Zitonggong Pharmaceutical Co ltd Sichuan
Priority to CN98111876A priority Critical patent/CN1084194C/en
Publication of CN1227748A publication Critical patent/CN1227748A/en
Application granted granted Critical
Publication of CN1084194C publication Critical patent/CN1084194C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The invention discloses a new method for preparing ultramicro infant essence, which mainly comprises the steps of ultramicro pulverization (the grain diameter of the traditional Chinese medicine is below 10 um), remixing, granulation, drying and split charging.

Description

A kind of method for preparing ultra micro baby element
The present invention relates to the pharmaceutical technology field, particularly relate to a kind of new method for preparing ultra micro baby element.
Traditional baby that preparation method obtained is plain to be unfavorable for the absorption of active ingredient in baby's element only with about raw material pulverizing to 100 order, and its bioavailability is low; Mouthfeel is poor, is unsuitable for infant taking; Sanitary index is difficult to control, and is difficult for storing, and higher, production efficiency is low.
The objective of the invention is to be intended to overcome above-mentioned shortcoming, provide a kind of preparation have bioavailability height, mouthfeel good, be easy to active ingredient and absorb, improve the new method of baby's element of advantage such as sanitary index.
The object of the present invention is achieved like this: the present invention includes following steps: micronizing, mixing, granulation, dried particles, packing, warehouse-in;
Micronizing: after will cleaning the Semen Lablab Album, Rhizoma Dioscoreae, Endothelium Corneum Gigeriae Galli, the Rhizoma Atractylodis Macrocephalae, Bulbus Fritillariae Cirrhosae, the Radix Aucklandiae that are up to the standards and using the pulverizer coarse pulverization respectively, be ground into superfine powder and the abundant mixing for standby use of other supplementary material with the broken machine of ultra micro respectively again;
Mix: other gets the NaHCO of recipe quantity 3, Calculus Bovis, sucrose and micropowder are mixed together evenly,
Dried particles: add an amount of moistening temperature agent and go into to stir into soft material in the mixture, granulate with the sieve of 500 μ m, 80 ℃ of oven dry add an amount of aromatic (edible essence) and mix barrelling behind the granulate;
Packing: through the fine grained that is up to the standards granule racking machine, with the subpackage of 1g/ bag.With capsule of 12 packings, with 200 box-packed one big cartons, promptly wrap 1=12 bags * 200 boxes=2400;
Warehouse-in: through the product inspection warehousing after passing;
The present invention has following advantage:
1. ultra micro: Chinese medicine micronization (particle diameter is below 10 μ m) is helped the stripping and the absorption of active ingredient, bioavailability height;
2. owing to increase correctives and aromatic, mouthfeel is better than former baby's element, more is applicable to infant taking.
3. granule is tiny, and moisture content is more easy to control, is beneficial to storage;
4. aspect sanitary index, be greatly improved than former baby's element;
5. good effect, cost is low;
The invention will be further described below in conjunction with embodiment:
The present invention includes following steps: micronizing, mixing, granulation, dried particles, packing, warehouse-in;
Micronizing: after will cleaning the Semen Lablab Album, Rhizoma Dioscoreae, Endothelium Corneum Gigeriae Galli, the Rhizoma Atractylodis Macrocephalae, Bulbus Fritillariae Cirrhosae, the Radix Aucklandiae that are up to the standards and using the pulverizer coarse pulverization respectively, be ground into micropowder with the broken machine of ultra micro respectively again,
Mix: other gets the NaHCO of recipe quantity 3, Calculus Bovis, sucrose and micropowder are mixed together evenly,
Dried particles: add an amount of moistening temperature agent and go into to stir into soft material in the mixture, granulate with the sieve of 500 μ m, 80 ℃ of oven dry add an amount of aromatic (edible essence) and mix barrelling behind the granulate;
Packing: through the fine grained that is up to the standards granule racking machine, with the subpackage of 1g/ bag.With capsule of 12 packings, with 200 box-packed one big cartons, promptly wrap 1=12 bags * 200 boxes=2400;
Warehouse-in: through the product inspection warehousing after passing;
The present invention absorbs Chinese medicine micronization (particle diameter is below 10 μ m) soon by ultra micro, and the active ingredient stripping is many, the bioavailability height; Because increase correctives and aromatic, mouthfeel is better than former baby's element, more is applicable to infant taking.Granule is tiny, easier storage; Aspect sanitary index, have raising greatly than former baby; Good effect.

Claims (1)

1, a kind of method for preparing ultra micro baby element, may further comprise the steps: micronizing, mixing, granulation, dried particles is characterized in that:
Micronizing: after will cleaning the Semen Lablab Album, Rhizoma Dioscoreae, Endothelium Corneum Gigeriae Galli, the Rhizoma Atractylodis Macrocephalae, Bulbus Fritillariae Cirrhosae, the Radix Aucklandiae that are up to the standards and using the pulverizer coarse pulverization respectively, be ground into the superfine powder of particle diameter below 10 μ m with super micron mill respectively again, and with the abundant mixing for standby use of other supplementary material;
Mix: other gets NaHCO 3, Calculus Bovis, sucrose and micropowder be mixed together evenly;
Dried particles: add an amount of moistening temperature agent and go into to stir into soft material in the mixture, granulate with the sieve of 500 μ m, 80 ℃ of oven dry add an amount of aromatic mixing and get final product behind the granulate.
CN98111876A 1998-03-03 1998-03-03 Method for preparing ultramicro infant essence Expired - Lifetime CN1084194C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN98111876A CN1084194C (en) 1998-03-03 1998-03-03 Method for preparing ultramicro infant essence

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN98111876A CN1084194C (en) 1998-03-03 1998-03-03 Method for preparing ultramicro infant essence

Publications (2)

Publication Number Publication Date
CN1227748A CN1227748A (en) 1999-09-08
CN1084194C true CN1084194C (en) 2002-05-08

Family

ID=5221760

Family Applications (1)

Application Number Title Priority Date Filing Date
CN98111876A Expired - Lifetime CN1084194C (en) 1998-03-03 1998-03-03 Method for preparing ultramicro infant essence

Country Status (1)

Country Link
CN (1) CN1084194C (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101596269B (en) * 2008-06-02 2011-08-17 北京亚东生物制药有限公司 Method for controlling quality of infant spleen tonifyning granules

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109010584A (en) * 2018-08-24 2018-12-18 江西济民可信药业有限公司 A kind of preparation method of tonifying spleen granule for infants

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
《基层中药杂志》1995,9(4) 1995.4.1 吴玲娣，"中药固体制剂与人体吸收的探讨" *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101596269B (en) * 2008-06-02 2011-08-17 北京亚东生物制药有限公司 Method for controlling quality of infant spleen tonifyning granules

Also Published As

Publication number Publication date
CN1227748A (en) 1999-09-08

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Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C41 Transfer of patent application or patent right or utility model
TA01 Transfer of patent application right

Effective date of registration: 20010928

Applicant after: Three Nine Zitonggong Pharmaceutical Co.,Ltd. Sichuan

Applicant before: ZITONGGONG PHARMACEUTICAL Co.,Ltd. SICHUAN

C14 Grant of patent or utility model
GR01 Patent grant
CI01 Publication of corrected invention patent application

Correction item: Patentee

Correct: 39 Sichuan zitonggong Pharmaceutical Co. Ltd.

False: Three-Nine Zitonggong Pharmaceutical Co., Ltd., Sichuan

Number: 19

Page: 221

Volume: 18

CI03 Correction of invention patent

Correction item: Patentee

Correct: 39 Sichuan zitonggong Pharmaceutical Co. Ltd.

False: Three-Nine Zitonggong Pharmaceutical Co., Ltd., Sichuan

Number: 19

Page: The title page

Volume: 18

COR Change of bibliographic data

Free format text: CORRECT: PATENTEE; FROM: SICHUAN PROVINCE PHARMACEUTICAL CO., LTD. TO: SICHUAN PROVINCE GONG PHARMACEUTICAL CO., LTD.

ERR Gazette correction

Free format text: CORRECT: PATENTEE; FROM: SICHUAN PROVINCE PHARMACEUTICAL CO., LTD. TO: SICHUAN PROVINCE GONG PHARMACEUTICAL CO., LTD.

ASS Succession or assignment of patent right

Owner name: CHONGQING SANJIU MEDICINE CO., LTD.

Free format text: FORMER OWNER: SICHUAN PROVINCE GONG PHARMACEUTICAL CO., LTD.

Effective date: 20030725

C41 Transfer of patent application or patent right or utility model
TR01 Transfer of patent right

Effective date of registration: 20030725

Address after: Four 408000 Ring Road, Fuling District, Chongqing

Patentee after: Chongqing Sanjiu Pharmaceutial Co.,Ltd.

Address before: 641006 Huang Jingkan, Shizhong District, Sichuan, Neijiang

Patentee before: 39 Sichuan zitonggong Pharmaceutical Co.,Ltd.

C56 Change in the name or address of the patentee

Owner name: SUNFLOWER PHARMACEUTICAL GROUP(CHONGQING )CO.LTD.

Free format text: FORMER NAME OR ADDRESS: CHONGQING YUYI PHARMACY CO., LTD.

Owner name: CHONGQING YUYI PHARMACY CO., LTD.

Free format text: FORMER NAME OR ADDRESS: CHONGQING SANJIU MEDICINE CO., LTD.

CP01 Change in the name or title of a patent holder

Address after: Four ring road, Fuling District, Chongqing: 408000

Patentee after: Sunflower Medicine Industry Group (Chongqing) Co.,Ltd.

Address before: Four ring road, Fuling District, Chongqing: 408000

Patentee before: CHONGQING YUYI PHARMACEUTIC INDUSTRY Co.,Ltd.

Address after: Four ring road, Fuling District, Chongqing: 408000

Patentee after: CHONGQING YUYI PHARMACEUTIC INDUSTRY Co.,Ltd.

Address before: Four ring road, Fuling District, Chongqing: 408000

Patentee before: Chongqing Sanjiu Pharmaceutial Co.,Ltd.

CX01 Expiry of patent term
CX01 Expiry of patent term

Granted publication date: 20020508