JP3521969B2 - Powder of propolis extract and method for producing the same - Google Patents
Powder of propolis extract and method for producing the sameInfo
- Publication number
- JP3521969B2 JP3521969B2 JP21292794A JP21292794A JP3521969B2 JP 3521969 B2 JP3521969 B2 JP 3521969B2 JP 21292794 A JP21292794 A JP 21292794A JP 21292794 A JP21292794 A JP 21292794A JP 3521969 B2 JP3521969 B2 JP 3521969B2
- Authority
- JP
- Japan
- Prior art keywords
- propolis
- powder
- propolis extract
- extract
- starch hydrolyzate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 241000241413 Propolis Species 0.000 title claims description 79
- 229940069949 propolis Drugs 0.000 title claims description 79
- 239000000843 powder Substances 0.000 title claims description 38
- 238000004519 manufacturing process Methods 0.000 title claims description 22
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 48
- 229920002472 Starch Polymers 0.000 claims description 34
- 239000008107 starch Substances 0.000 claims description 34
- 235000019698 starch Nutrition 0.000 claims description 34
- 238000000034 method Methods 0.000 claims description 22
- 239000000203 mixture Substances 0.000 claims description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 12
- 239000008101 lactose Substances 0.000 claims description 11
- 238000002036 drum drying Methods 0.000 claims description 10
- 238000003756 stirring Methods 0.000 claims description 10
- 239000002775 capsule Substances 0.000 description 12
- 238000001035 drying Methods 0.000 description 12
- 239000000546 pharmaceutical excipient Substances 0.000 description 8
- 239000004480 active ingredient Substances 0.000 description 6
- 239000008187 granular material Substances 0.000 description 5
- 239000003814 drug Substances 0.000 description 4
- 239000002994 raw material Substances 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- 238000001179 sorption measurement Methods 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 235000008331 Pinus X rigitaeda Nutrition 0.000 description 3
- 235000011613 Pinus brutia Nutrition 0.000 description 3
- 241000018646 Pinus brutia Species 0.000 description 3
- 235000009508 confectionery Nutrition 0.000 description 3
- 238000005429 filling process Methods 0.000 description 3
- 235000013402 health food Nutrition 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 239000000543 intermediate Substances 0.000 description 3
- 230000000704 physical effect Effects 0.000 description 3
- 229920001353 Dextrin Polymers 0.000 description 2
- 239000004375 Dextrin Substances 0.000 description 2
- 241000257303 Hymenoptera Species 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- 235000019425 dextrin Nutrition 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 229930003935 flavonoid Natural products 0.000 description 2
- 150000002215 flavonoids Chemical class 0.000 description 2
- 235000017173 flavonoids Nutrition 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 150000007524 organic acids Chemical class 0.000 description 2
- 235000005985 organic acids Nutrition 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 229940124597 therapeutic agent Drugs 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 description 1
- WBYWAXJHAXSJNI-SREVYHEPSA-N Cinnamic acid Chemical compound OC(=O)\C=C/C1=CC=CC=C1 WBYWAXJHAXSJNI-SREVYHEPSA-N 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 102220547770 Inducible T-cell costimulator_A23L_mutation Human genes 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 229930016911 cinnamic acid Natural products 0.000 description 1
- 235000013985 cinnamic acid Nutrition 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 235000012907 honey Nutrition 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000011344 liquid material Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 239000012261 resinous substance Substances 0.000 description 1
- 102220214412 rs886288172 Human genes 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
Landscapes
- Jellies, Jams, And Syrups (AREA)
- Formation And Processing Of Food Products (AREA)
Description
【発明の詳細な説明】Detailed Description of the Invention
【０００１】[0001]
【産業上の利用分野】この発明は、健康食品、医薬品及
び化粧品などとして利用されるプロポリス抽出物の粉末
及びその製造方法に関するものである。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a powder of propolis extract used for health foods, pharmaceuticals, cosmetics and the like, and a method for producing the same.
【０００２】[0002]
【従来の技術】プロポリスは蜂蜜や花粉と同じように、
ミツバチが種々の植物から採取してきた樹脂状物質であ
る。このプロポリスは、紀元前４世紀、アリストテレス
の動物誌に「皮膚疾患、切り傷、感染症の治療薬」とし
て記載されているように、消炎効果や抗菌性があり、最
近では癌治療の治療薬としての研究成果が発表されてい
る。従って、プロポリスは今後も新しい効能が発見され
ることが期待されている素材である。プロポリスは多種
多様な有効成分を有しているが、有効成分はフラボノイ
ドのような親油性の成分、有機酸のような親水性の成
分、さらにはこれらの中間成分、その他ビタミン、ミネ
ラルである。そして、これらの有効成分を含水エタノー
ルで抽出したプロポリス抽出物の含水エタノール溶液が
健康食品、医薬品及び化粧品等の原料素材として使われ
ている。[Prior Art] Propolis, like honey and pollen,
Bees are resinous substances collected from various plants. This propolis has anti-inflammatory and antibacterial properties, as recently described in the Aristotle's animal magazine "Therapeutic agents for skin diseases, cuts, and infectious diseases" in the 4th century BC, and recently as a therapeutic agent for cancer treatment. Research results have been announced. Therefore, propolis is a material that is expected to discover new effects in the future. Propolis has a wide variety of active ingredients, and the active ingredients are lipophilic ingredients such as flavonoids, hydrophilic ingredients such as organic acids, and intermediates thereof, and other vitamins and minerals. A water-containing ethanol solution of a propolis extract obtained by extracting these active ingredients with water-containing ethanol is used as a raw material for health foods, pharmaceuticals, cosmetics and the like.
【０００３】一方、錠剤やカプセルの製造に適した物性
を有するプロポリス抽出物の粉末は製造、販売されてい
ない。そのため、通常スプレードライヤー法による澱
粉、デキストリンのような賦形剤に少量のプロポリス抽
出物の含水エタノール溶液を添加し、乾燥した後粉末化
あるいは顆粒化して錠剤やカプセルの製造が行われてい
る。On the other hand, no powder of propolis extract having physical properties suitable for producing tablets or capsules has been produced or sold. For this reason, tablets and capsules are usually produced by spray-drying a method in which a small amount of an aqueous ethanol solution of propolis extract is added to an excipient such as starch and dextrin, dried and then pulverized or granulated.
【０００４】[0004]
【発明が解決しようとする課題】前述のプロポリス抽出
物の含水エタノール溶液は液状であるため取扱いが不便
である上に、容器、器具、皮膚、肌や衣服に付着すると
洗浄除去が極めて困難である。また、そのままでは健康
食品の主要剤形である錠剤やカプセルの製造ができない
という問題があった。The water-containing ethanolic solution of the propolis extract described above is liquid, which makes it inconvenient to handle and is extremely difficult to wash and remove when it adheres to containers, equipment, skin, skin or clothes. . Further, there is a problem in that tablets and capsules, which are the main dosage forms of health foods, cannot be produced as they are.
【０００５】錠剤、カプセルの製造に使用されるプロポ
リスの粉末や顆粒を得る場合、従来用いられている賦形
剤はプロポリス抽出物溶液の吸収が悪いため、製造され
る粉末又は顆粒はプロポリス抽出物の含量が１０重量％
程度が限界である。従って、錠剤やカプセルのような小
型の製品中に、摂取量に見合った量のプロポリス抽出物
を高濃度に含有した粉末や顆粒は得られていない。When obtaining a powder or granules of propolis used for the production of tablets and capsules, the conventionally used excipients have poor absorption of the propolis extract solution, and thus the powder or granules produced are the propolis extract. Content of 10% by weight
The degree is the limit. Therefore, powders or granules containing a high concentration of the propolis extract in an amount commensurate with the intake amount have not been obtained in small products such as tablets and capsules.
【０００６】粉末や顆粒の製造工程においても、乾燥中
にプロポリス抽出物を含有した混合物が飴化して乾燥が
できなくなったり、乾燥品の粉末化が困難となるなどの
問題があった。しかも、出来上がった粉末や顆粒の流動
性が悪く、打錠又はカプセル充填工程に支障を来すなど
の問題もあった。Also in the process of producing powders and granules, there are problems that the mixture containing the propolis extract is candy during drying and cannot be dried, and it becomes difficult to powder the dried product. Moreover, the fluidity of the finished powder or granules is poor, and there is a problem that the tableting or capsule filling process is hindered.
【０００７】この発明は上記のような従来技術の問題に
着目してなされたものである。その目的とするところ
は、プロポリス抽出物を高濃度に含有し、錠剤やカプセ
ルのような小型の製品中に、摂取量に見合った量のプロ
ポリス抽出物を容易に得ることができるプロポリス抽出
物の粉末及びその製造方法を提供することにある。The present invention has been made by paying attention to the problems of the prior art as described above. Its purpose is to contain a high concentration of propolis extract, in a small product such as tablets and capsules, the amount of propolis extract can easily be obtained in an amount commensurate with intake It is intended to provide a powder and a manufacturing method thereof.
【０００８】他の目的とするところは、プロポリス抽出
物の含水エタノール溶液からプロポリス抽出物の粉末を
効率良く得ることができ、プロポリス抽出物の錠剤又は
カプセル製品への転換を容易にでき、打錠又はカプセル
充填工程におけるトラブルを防止できるプロポリス抽出
物の粉末の製造方法を提供することにある。Another object is to efficiently obtain a powder of the propolis extract from an aqueous ethanol solution of the propolis extract, to easily convert the propolis extract into a tablet or capsule product, and to compress the tablet. Another object of the present invention is to provide a method for producing a powder of a propolis extract which can prevent troubles in the capsule filling process.
【０００９】[0009]
【課題を解決するための手段】上記目的を達成するため
に、請求項１に記載のプロポリス抽出物の粉末の製造方
法の発明では、ドラム乾燥法により製造された薄片状の
澱粉加水分解物を攪拌しながら、これにプロポリス抽出
物の含水エタノール溶液を添加し、得られた混合物を乾
燥した後、粉砕するものである。In order to achieve the above object, a method for producing a powder of propolis extract according to claim 1.
In the method invention, a flaky product produced by the drum drying method is used.
While stirring the starch hydrolyzate, extract it with propolis.
Water-containing ethanol solution, and dry the resulting mixture.
It is dried and then crushed .
【００１０】また、請求項２に記載のプロポリス抽出物
の粉末の製造方法の発明では、ドラム乾燥法により製造
された薄片状の澱粉加水分解物及び乳糖を攪拌しなが
ら、プロポリス抽出物の含水エタノール溶液を添加し、
得られた混合物を乾燥した後、粉砕するものである。さ
らに、請求項３に記載のプロポリス抽出物の粉末の発明
では、請求項１又は請求項２に記載のプロポリス抽出物
の粉末の製造方法によって得られたものである。The propolis extract according to claim 2
In the invention of the method for manufacturing the powder, produced by drum drying method
While stirring the flaky starch hydrolyzate and lactose
, A hydrous ethanolic solution of propolis extract was added,
The obtained mixture is dried and then pulverized . Furthermore, the powder of inventions of propolis extract according to claim 3, propolis extract according to claim 1 or claim 2
It is obtained by the method for producing a powder .
【００１１】[0011]
【００１２】以下に、この発明について詳細に説明す
る。この発明に用いられるプロポリス抽出物の原料とな
るプロポリスは、蜂が集めた黒い塊であって、ブラジル
産プロポリス、中国産プロポリスなどいずれの産地のも
のであってもよい。プロポリスは親油性の成分、親水性
の成分、それらの中間の性質を有する成分及びその他の
成分を含有している。親油性の成分としてはフラボノイ
ドなどがあげられ、親水性の成分としてはケイ皮酸、ク
マール酸などの有機酸があげられる。また、親油性と親
水性の中間の性質を有する成分としてはエステル類があ
げられ、その他の成分としては各種ビタミン、ミネラル
などがあげられる。The present invention will be described in detail below. The propolis used as a raw material for the propolis extract used in the present invention is a black mass collected by bees, and may be of any production source such as Brazilian propolis and Chinese propolis. Propolis contains a lipophilic component, a hydrophilic component, a component having properties intermediate between them, and other components. Examples of lipophilic components include flavonoids, and examples of hydrophilic components include organic acids such as cinnamic acid and coumaric acid. In addition, examples of components having an intermediate property between lipophilicity and hydrophilicity include esters, and examples of other components include various vitamins and minerals.
【００１３】このように、プロポリスは多種類の成分を
含有していることから、エタノール単独や水単独の溶媒
ではプロポリス中の有効成分を効率良く抽出することが
できない。従って、この発明では、水を含有するエタノ
ール溶液により原料プロポリスからプロポリス中の有効
成分を抽出する。この含水エタノール溶液は、エタノー
ル含有量８０重量％程度、従って水の含有量２０重量％
程度のものが原料プロポリスから各種有効成分を抽出す
るのに好適であるが、これに限定されず、エタノールと
水の割合を増減させてもよい。As described above, since propolis contains various kinds of components, it is not possible to efficiently extract the active ingredient in propolis with a solvent containing ethanol alone or water alone. Therefore, in the present invention, the active ingredient in propolis is extracted from the raw material propolis with an ethanol solution containing water. This water-containing ethanol solution has an ethanol content of about 80% by weight, and therefore a water content of 20% by weight.
Although a suitable amount is suitable for extracting various active ingredients from the raw material propolis, the present invention is not limited to this, and the ratio of ethanol and water may be increased or decreased.
【００１４】抽出されたプロポリスを含む含水エタノー
ル溶液中のプロポリス抽出物濃度に制限はないが、２０
〜７０重量％の範囲が好ましい。この濃度が２０重量％
未満では乾燥時に多量のエタノールや水を蒸発させる必
要があり、７０重量％を超えると含水エタノール溶液の
粘度が高くなり過ぎる。The concentration of the propolis extract in the hydrous ethanol solution containing the extracted propolis is not limited, but 20
The range of ˜70% by weight is preferred. This concentration is 20% by weight
If it is less than 70% by weight, it is necessary to evaporate a large amount of ethanol or water during drying, and if it exceeds 70% by weight, the viscosity of the hydrous ethanol solution becomes too high.
【００１５】次に、賦形剤として用いられる澱粉の加水
分解物は、ドラム乾燥法で製造された薄片状の澱粉加水
分解物が好ましく、具体的には松谷化学工業（株）製の
商品名パインフローがあげられる。ドラム乾燥法は、澱
粉加水分解物の液状物をドラム表面に付着させるととも
に、ドラム内部に蒸気を入れドラム壁を介して加熱し、
ドラムの回転に従って乾燥させる方法である。この方法
により、薄片状となった澱粉の加水分解物が得られる。
この方法によれば、乾燥時間は短く、乾燥速度も速い上
に、連続操作も可能である。Next, the starch hydrolyzate used as an excipient is preferably a flaky starch hydrolyzate produced by a drum drying method. Specifically, it is a trade name of Matsutani Chemical Industry Co., Ltd. Pine flow can be given. In the drum drying method, liquid material of starch hydrolyzate is attached to the surface of the drum, steam is put inside the drum and heated through the drum wall,
It is a method of drying by rotating the drum. By this method, a flaky starch hydrolyzate is obtained.
According to this method, the drying time is short, the drying speed is fast, and continuous operation is possible.
【００１６】この澱粉加水分解物は従来のスプレードラ
イヤー法により得られるものが球状であるのに対し薄片
状である。そのため、極めて大きい嵩密度、すなわち大
きい比表面積、例えば８．５cm3/g を有しており、プロ
ポリス中の各成分を多量に吸着することができる。ま
た、この澱粉加水分解物のＤＥ（ブドウ糖当量）は好ま
しくは１８以下、さらに好ましくは３．５〜１８の範囲
である。この値が１８を超えると、吸湿性が大きくなっ
てプロポリス抽出物の含水エタノール溶液を添加したと
き飴状になり、３．５未満ではほとんど加水分解されて
おらず、物性の良い粉末状の製品を得ることはできな
い。なお、澱粉加水分解物の粒度は例えば３２〜２００
メッシュの範囲である。This starch hydrolyzate is flaky, whereas the one obtained by the conventional spray dryer method is spherical. Therefore, it has an extremely large bulk density, that is, a large specific surface area, for example, 8.5 cm 3 / g, and can adsorb a large amount of each component in propolis. The DE (glucose equivalent) of this starch hydrolyzate is preferably 18 or less, more preferably 3.5 to 18. If this value exceeds 18, the hygroscopicity becomes large and the product becomes candy-like when a hydrous ethanol solution of propolis extract is added, and if it is less than 3.5, it is hardly hydrolyzed and is a powdery product with good physical properties. Can't get The particle size of the starch hydrolyzate is, for example, 32-200.
This is the range of the mesh.
【００１７】この発明では、賦形剤として上記澱粉の加
水分解物の一部を嵩密度の小さい乳糖に代えることがで
き、その場合賦形剤の嵩密度を調整することができると
ともに、プロポリス抽出物の吸着能を調整することがで
きる。この乳糖の使用量は、澱粉の加水分解物と乳糖の
合計量に対し、５０重量％以下が好ましく、１０〜３０
重量％の範囲がさらに好ましい。In the present invention, a part of the starch hydrolyzate can be replaced with lactose having a low bulk density as an excipient, in which case the bulk density of the excipient can be adjusted and the propolis extraction can be performed. The adsorption capacity of the substance can be adjusted. The amount of lactose used is preferably 50% by weight or less, based on the total amount of the starch hydrolyzate and lactose, and is 10 to 30%.
A range of weight% is more preferable.
【００１８】但し、乳糖のみでは澱粉の加水分解物が含
水エタノール溶液に溶けて飴になり、賦形剤の機能を果
たさないため好ましくない。通常のデキストリンは吸着
量が少なく、飴にもなり易いので乾燥することもできな
いため、賦形剤として不適当である。さらに、澱粉は吸
着量が少なく、高濃度の製品が得られないため、賦形剤
として好ましくない。However, lactose alone is not preferable because the hydrolyzate of starch dissolves in a water-containing ethanol solution to form candy, which does not function as an excipient. Ordinary dextrin is not suitable as an excipient because it has a small amount of adsorption and easily becomes a candy and cannot be dried. Furthermore, starch is not preferable as an excipient because it has a low adsorption amount and a high-concentration product cannot be obtained.
【００１９】次に、プロポリス抽出物の粉末の製造方法
について説明する。まず、ドラム乾燥法により薄片状の
澱粉加水分解物を製造する。続いて、この澱粉加水分解
物をミキサーなどの容器に入れて攪拌する。攪拌速度は
１００〜３２０rpm の範囲が好ましく、２００rpm 前後
が特に好ましい。そして、この中へプロポリス抽出物の
含水エタノール溶液を徐々に添加する。この添加速度
は、澱粉加水分解物１０kg当たり０．５〜２．５kg／mi
n の範囲が好ましく、１kg／min 前後が最も好ましい。
得られた混合物を熱風乾燥器などで５０℃前後の温度に
て２４時間程度乾燥する。その後、衝撃式粉砕機などで
粉砕し、篩分けすることにより、プロポリス抽出物の粉
末が製造される。Next, a method for producing a powder of propolis extract will be described. First, a flaky starch hydrolyzate is produced by a drum drying method. Then, the starch hydrolyzate is placed in a container such as a mixer and stirred. The stirring speed is preferably in the range of 100 to 320 rpm, particularly preferably around 200 rpm. Then, a hydrous ethanolic solution of the propolis extract is gradually added to this. This addition rate is 0.5 to 2.5 kg / mi per 10 kg of starch hydrolyzate.
The range of n is preferable, and about 1 kg / min is most preferable.
The obtained mixture is dried at a temperature of about 50 ° C. for about 24 hours using a hot air dryer or the like. Then, the powder of the propolis extract is produced by crushing with an impact crusher or the like and sieving.
【００２０】この粉末中のプロポリス濃度は好ましくは
２０〜７０重量％、さらに好ましくは３０〜５０重量％
である。２０重量％未満では、錠剤やカプセルのような
小型の製品中に摂取量に見合ったプロポリス抽出物量を
得ることができず、７０重量％を超えると、製造工程に
おいて生成物の粘性が高くなって製造が困難になる。こ
のような製品中の高いプロポリス濃度は従来法では困難
であった
この方法において、薄片状の澱粉加水分解物の優れた吸
着性、高い嵩密度、良好な粉末物性により、乾燥や粉砕
が容易に行われる。すなわち、薄片状の澱粉加水分解物
は複雑な組成のプロポリス抽出物を吸着し、その状態で
乾燥や粉末化が行われるため、乾燥や粉砕が効果的に行
われる。The concentration of propolis in this powder is preferably 20 to 70% by weight, more preferably 30 to 50% by weight.
Is. If it is less than 20% by weight, the amount of propolis extract commensurate with the intake cannot be obtained in a small product such as a tablet or capsule, and if it exceeds 70% by weight, the viscosity of the product increases in the manufacturing process. Manufacturing becomes difficult. High propolis concentration in such products was difficult with the conventional method, but in this method, excellent adsorption of flaky starch hydrolyzate, high bulk density, and good powder physical properties make it easy to dry and grind. Done. That is, since the flaky starch hydrolyzate adsorbs the propolis extract having a complicated composition and is dried and pulverized in that state, drying and pulverization are effectively performed.
【００２１】なお、この製造工程において、薄片状の澱
粉加水分解物が攪拌されないと、プロポリス抽出物の含
水エタノール溶液が添加されるときに、澱粉加水分解物
が水に溶けやすいため部分的に水飴状態となり、乾燥が
部分的に不完全になる。また、操作をこの発明とは逆に
して、プロポリス抽出物の含水エタノール溶液に薄片状
の澱粉加水分解物を加えると、澱粉加水分解物が含水エ
タノール溶液に溶解して全体が水飴状になるため、不適
当である。In this manufacturing process, if the flaky starch hydrolyzate is not stirred, the starch hydrolyzate easily dissolves in water when the hydrous ethanol solution of the propolis extract is added, so that the starch syrup is partially dissolved. And the drying is partially incomplete. In addition, the procedure is reversed from this invention, and when flaky starch hydrolyzate is added to the hydrous ethanol solution of the propolis extract, the starch hydrolyzate is dissolved in the hydrous ethanol solution and the whole becomes starch syrup-like. Is inappropriate.
【００２２】[0022]
【作用】請求項１に記載のプロポリス抽出物の粉末の製
造方法においては、ドラム乾燥法により製造された薄片
状の澱粉加水分解物が攪拌されつつ、プロポリス抽出物
の含水エタノール溶液が添加される。得られた混合物が
乾燥された後、粉砕されてプロポリス抽出物の粉末が製
造される。この場合、薄片状の澱粉加水分解物の優れた
吸着性、高い嵩密度、良好な粉末物性により、乾燥や粉
砕が容易に行われる。すなわち、薄片状の澱粉加水分解
物はプロポリス抽出物を吸着し、その状態で乾燥や粉末
化が効率良く行われる。 The production of the powder of the propolis extract according to claim 1
In the manufacturing method , flakes produced by the drum drying method
-Like starch hydrolyzate with stirring, propolis extract
Of water containing ethanol solution is added. The resulting mixture is
After being dried, it is crushed to make powder of propolis extract.
Is built. In this case, the flaky starch hydrolyzate was excellent.
Due to its adsorptivity, high bulk density and good powder properties, it can be dried or powdered.
Crushing is easy. That is, flaky starch hydrolysis
The substance adsorbs the propolis extract and is dried or powdered in that state.
Conversion is performed efficiently.
【００２３】請求項２に記載の発明では、ドラム乾燥法
により製造された薄片状の澱粉加水分解物と乳糖が攪拌
された状態で、プロポリス抽出物の含水エタノール溶液
が添加される。以後、請求項１の方法と同様にしてプロ
ポリス抽出物の粉末が製造される。 According to the second aspect of the invention, the drum drying method is used.
The flaky starch hydrolyzate and lactose produced by
Solution of propolis extract in water
Is added. After that, in the same manner as in the method of claim 1,
A powder of police extract is produced.
【００２４】[0024]
【００２５】[0025]
【００２６】[0026]
【実施例】以下に実施例をあげてこの発明をさらに具体
的に説明する。
（実施例１）ドラム乾燥法で製造された薄片状の澱粉加
水分解物（松谷化学工業（株）製の商品名パインフロ
ー）８．０kgをミキサーで２００rpm の攪拌速度にて攪
拌しながら、これにブラジル産のプロポリス抽出物の含
水エタノール溶液（固形分濃度６０重量％）３．４kgを
１kg／min の添加速度で徐々に添加した。EXAMPLES The present invention will be described in more detail with reference to the following examples. (Example 1) 8.0 kg of flaky starch hydrolyzate (trade name Pineflow manufactured by Matsutani Chemical Industry Co., Ltd.) produced by a drum drying method was stirred with a mixer at a stirring speed of 200 rpm. Then, 3.4 kg of a hydrous ethanolic solution of propolis extract from Brazil (solid content concentration 60% by weight) was gradually added at an addition rate of 1 kg / min.
【００２７】全体が均一の混合物となってから、この混
合物を棚式の熱風乾燥器にて５０℃で２４時間乾燥し
た。乾燥物が冷却された後、これを衝撃式粉砕機で粉砕
した。次いで、これを６０メッシュの篩で篩分けしてプ
ロポリス抽出物の２０％含有粉末（乾燥減量１．０％）
１０．１kgを得た。
（実施例２）パインフロー５．０kgと乳糖３．０kgとを
ミキサーで２００rpm の攪拌速度にて攪拌しながら、こ
れにブラジル産のプロポリス抽出物の含水エタノール溶
液（固形分濃度６０重量％）３．４kgを１kg／min の添
加速度で徐々に添加した。After the whole mixture became a uniform mixture, this mixture was dried at 50 ° C. for 24 hours in a tray-type hot air dryer. After the dried product was cooled, it was crushed with an impact crusher. Then, this was sieved with a 60 mesh sieve and powder containing 20% of propolis extract (loss on drying 1.0%)
10.1 kg was obtained. (Example 2) Pine flow (5.0 kg) and lactose (3.0 kg) were stirred with a mixer at a stirring speed of 200 rpm, and a hydrous ethanol solution of a propolis extract from Brazil (solid content concentration 60% by weight) 3 was added thereto. 0.4 kg was gradually added at an addition rate of 1 kg / min.
【００２８】全体が均一の混合物となってから、この混
合物を棚式の熱風乾燥器にて５０℃で２４時間乾燥し
た。乾燥物が冷却された後、これを衝撃式粉砕機で粉砕
した。次いで、これを６０メッシュの篩で篩分けしてプ
ロポリス抽出物の２０％含有粉末（乾燥減量１．２％）
９．８kgを得た。
（実施例３）パインフロー５．０kgをミキサーで２００
rpm の攪拌速度にて攪拌しながら、これにブラジル産の
プロポリス抽出物の含水エタノール溶液（固形分濃度６
０重量％）８．３kgを１kg／min の添加速度で徐々に添
加した。After the whole mixture became a uniform mixture, this mixture was dried at 50 ° C. for 24 hours in a tray-type hot air dryer. After the dried product was cooled, it was crushed with an impact crusher. Then, this was sieved with a 60 mesh sieve and powder containing 20% of propolis extract (loss on drying 1.2%)
9.8 kg was obtained. (Example 3) 200 kg of pine flow was mixed with a mixer.
While stirring at a stirring speed of rpm, a hydrous ethanolic solution of propolis extract from Brazil (solid content 6
8.3 kg (0% by weight) was gradually added at an addition rate of 1 kg / min.
【００２９】全体が均一の混合物となってから、この混
合物を棚式の熱風乾燥器にて５０℃で２４時間乾燥し
た。乾燥物が冷却された後、これを衝撃式粉砕機で粉砕
した。次いで、これを６０メッシュの篩で篩分けしてプ
ロポリス抽出物の５０％含有粉末（乾燥減量１．２％）
９．８kgを得た。After the whole mixture became a uniform mixture, this mixture was dried at 50 ° C. for 24 hours in a tray-type hot air dryer. After the dried product was cooled, it was crushed with an impact crusher. Then, this was sieved with a 60-mesh sieve and powder containing 50% of propolis extract (loss on drying 1.2%)
9.8 kg was obtained.
【００３０】なお、この発明は上記実施例に限定される
ものではなく、例えば以下のように構成を変更して具体
化してもよい。
（ａ）プロポリスとして、成分すなわち産地の異なる２
種以上のものを組合せて用いること。
（ｂ）実施例１〜３において、プロポリス抽出物の含水
エタノール溶液の固形分濃度を変えたり、乾燥温度や乾
燥時間を変えること。また、目的とするプロポリス抽出
物の粉末に応じて、粒度を変えたり、プロポリス抽出物
の含有量を変えたりすること。The present invention is not limited to the above embodiment, and may be embodied by changing the configuration as follows, for example. (A) As propolis, 2 that have different ingredients, that is, different production areas
Use in combination with more than one kind. (B) In Examples 1 to 3, changing the solid content concentration of the hydrous ethanol solution of the propolis extract, or changing the drying temperature or the drying time. In addition, the particle size may be changed or the content of the propolis extract may be changed depending on the target powder of the propolis extract.
【００３１】ちなみに、前記実施態様より把握される請
求項以外の技術的思想について、以下にその効果ととも
に記載する。
（１）プロポリス抽出物の濃度が２０〜７０重量％であ
る含水エタノール溶液を用いた請求項１に記載のプロポ
リス抽出物の粉末の製造方法。この方法によれば、プロ
ポリス抽出物の粉末中のプロポリスの含有量を高めるこ
とができる。
（２）乳糖の濃度を薄片状の澱粉加水分解物と乳糖との
合計量に対し、２０〜４０重量％とした請求項２に記載
のプロポリス抽出物の粉末の製造方法。このようにすれ
ば、澱粉加水分解物と乳糖の混合物の嵩密度を容易に調
整することができる。By the way, technical ideas other than the claims understood from the embodiment will be described below together with their effects. (1) powder The method for producing a propolis extract according to claim 1 in which the concentration of propolis extract with aqueous ethanol solution is a 20 to 70% by weight. According to this method, the content of propolis in the powder of the propolis extract can be increased. (2) The method for producing a powder of a propolis extract according to claim 2, wherein the concentration of lactose is 20 to 40% by weight based on the total amount of flaky starch hydrolyzate and lactose. By doing so, the bulk density of the mixture of starch hydrolyzate and lactose can be easily adjusted.
【００３２】[0032]
【発明の効果】以上詳述したように、各請求項に記載の
プロポリス抽出物の粉末の製造方法及びその製造方法に
よって得られたプロポリス抽出物の粉末の発明によれ
ば、プロポリス抽出物のエタノール溶液からプロポリス
抽出物の粉末を効率良く製造することができる。そし
て、錠剤又はカプセル製品への転換を容易にでき、打錠
又はカプセル充填工程のトラブルを防止することができ
る。 As described above in detail, the manufacturing method and the manufacturing method thereof of the powder of propolis extract according to the claim
According to the invention of the powder of the propolis extract thus obtained, from the ethanol solution of the propolis extract
The powder of the extract can be efficiently produced. That
Can be easily converted into tablets or capsules and compressed into tablets.
Or it can prevent troubles in the capsule filling process.
It
【００３３】[0033]
【００３４】[0034]
───────────────────────────────────────────────────── フロントページの続き (72)発明者 半野 敬夫 兵庫県伊丹市荻野３丁目52−401 (56)参考文献 特開 昭60−141269（ＪＰ，Ａ) 特開 平４−262752（ＪＰ，Ａ) 特開 平１−181750（ＪＰ，Ａ) 特開 平５−316968（ＪＰ，Ａ) 特開 平４−316459（ＪＰ，Ａ) (58)調査した分野(Int.Cl.7，ＤＢ名) A23L 1/076 A23P 1/06 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Takao Hanno 3-52-401 Ogino, Itami City, Hyogo Prefecture (56) Reference JP-A-60-141269 (JP, A) JP-A-4-262752 (JP, A) ) JP-A-1-181750 (JP, A) JP-A-5-316968 (JP, A) JP-A-4-316459 (JP, A) (58) Fields investigated (Int.Cl. 7 , DB name) A23L 1/076 A23P 1/06
Claims (3)
澱粉加水分解物を攪拌しながら、これにプロポリス抽出
物の含水エタノール溶液を添加し、得られた混合物を乾
燥した後、粉砕するプロポリス抽出物の粉末の製造方
法。1. A flaky product produced by a drum drying method.
While stirring the starch hydrolyzate, extract it with propolis.
Water-containing ethanol solution, and dry the resulting mixture.
Method for producing powder of propolis extract that is dried and then crushed
Law .
澱粉加水分解物及び乳糖を攪拌しながら、プロポリス抽
出物の含水エタノール溶液を添加し、得られた混合物を
乾燥した後、粉砕するプロポリス抽出物の粉末の製造方
法。2. A flaky product produced by a drum drying method.
While stirring the starch hydrolyzate and lactose, extract the propolis.
Add the water-containing ethanolic solution of the product, and mix the resulting mixture.
How to make a powder of propolis extract that is dried and then crushed
Law .
ス抽出物の粉末の製造方法によって得られたプロポリス
抽出物の粉末。 3. The polypropolyamide according to claim 1 or 2.
Propolis obtained by the method for producing powder of pearl extract
Extract powder.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP21292794A JP3521969B2 (en) | 1994-09-06 | 1994-09-06 | Powder of propolis extract and method for producing the same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP21292794A JP3521969B2 (en) | 1994-09-06 | 1994-09-06 | Powder of propolis extract and method for producing the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH0870797A JPH0870797A (en) | 1996-03-19 |
| JP3521969B2 true JP3521969B2 (en) | 2004-04-26 |
Family
ID=16630599
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP21292794A Expired - Fee Related JP3521969B2 (en) | 1994-09-06 | 1994-09-06 | Powder of propolis extract and method for producing the same |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP3521969B2 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5922324A (en) * | 1995-01-31 | 1999-07-13 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Propolis extract with improved water-solubility |
-
1994
- 1994-09-06 JP JP21292794A patent/JP3521969B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0870797A (en) | 1996-03-19 |
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