CN108404191A - graphene oxide/lidocaine sponge dressing and preparation method thereof - Google Patents
graphene oxide/lidocaine sponge dressing and preparation method thereof Download PDFInfo
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- CN108404191A CN108404191A CN201810372838.1A CN201810372838A CN108404191A CN 108404191 A CN108404191 A CN 108404191A CN 201810372838 A CN201810372838 A CN 201810372838A CN 108404191 A CN108404191 A CN 108404191A
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- graphene oxide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/20—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/24—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/425—Porous materials, e.g. foams or sponges
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/402—Anaestetics, analgesics, e.g. lidocaine
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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Abstract
The present invention relates to a kind of graphene oxide/lidocaine sponge dressings and preparation method thereof.Sponge dressing includes following raw material components：20~500g polyvinyl alcohol, 1~20mL graphene oxides/lidocaine inclusion compound, 0.01~15g foaming agents, 10~400mL catalyst and 10~400mL crosslinking agents；Wherein, a concentration of 5~20mg/mL of graphene oxide/lidocaine inclusion compound.Compared with prior art, medical sponge dressing of the present invention combines the excellent properties such as graphene oxide, Li Kaduoyin and polyvinyl alcohol, have many advantages, such as that quick imbibition, a large amount of imbibitions, lock moisture big, antibacterial, analgesia, flexibility and elasticity are high, patient can be treated rapidly to be wound skin, mitigate the great pain that the surface of a wound is brought.In addition, medical sponge dressing simple production process of the present invention, cheap, easily realize industrialized production, be with a wide range of applications.
Description
Technical field
The present invention relates to biomedical material technologies, and in particular to a kind of graphene oxide/lidocaine sponge is deposited
Material and preparation method thereof.
Background technology
In recent years, with the fast development of transportation, petrochemical industry, construction industry etc., burn is in work and daily life
Incidence, disability rate and the death rate in work all increase year by year.According to statistics, China is every year because in the death toll of unexpected injury,
Burn arranges the 2nd, is only second to traffic accident injury.Wherein, China's burn Annual occurence rate about 2%, and about 5% burn patient needs
Hospitalization, for burn patient there are about the different degrees of deformity of 10% generation, this is all heavy to sufferers themselves, family and society in hospital
The burden of weight, is relationship happy family life, the significant problem of social stability.Therefore, it should treat, make as early as possible after skin is by wound
Tissue and functional rehabilitation, especially Burn Emergency patient are often patient just injured or that the injury time is short, and mood is eager,
Doctor's processing surface of a wound at once is wished, to mitigate the great pain that the surface of a wound is brought.
For above-mentioned present situation, tradition mostly uses greatly gauze and is used as medical dressing, gauze have protect the surface of a wound, derive from a wealth of sources,
Make the advantages that simple, cheap；But disadvantage is equally prominent：Surface of a wound wetting is cannot keep, histocyte epithelialization, wound are interfered
Face healing delay；Dressing fiber is easy to fall off, causes foreign body reaction, influences to heal；Wound granulation tissue easily grows into the mesh of dressing
In, when dressing, easily causes pain；Haemostatic effect is not good enough, and pathogen easily penetrates；The tissue of easy damaged new life when dressing；Dressing work
Work amount is big.
Based on this, there is an urgent need to invent a kind of quick imbibition, analgesic while having the dressing with slow release long-acting at present.
Invention content
For the defects in the prior art, the present invention is intended to provide a kind of graphene oxide/lidocaine sponge dressing and
Preparation method.It is excellent that medical sponge dressing provided by the invention combines graphene oxide, Li Kaduoyin and polyvinyl alcohol etc.
It is anisotropic can, have many advantages, such as big quick imbibition, a large amount of imbibitions, lock moisture, antibacterial, analgesia, flexibility and elastic high, can be rapid
Treatment patient is wound skin, mitigates the great pain that the surface of a wound is brought.In addition, medical sponge dressing simple production process of the present invention,
It is cheap, it easily realizes industrialized production, is with a wide range of applications.
To achieve the above object, technical solution provided by the invention is：
In a first aspect, the present invention provides a kind of sponge dressing, the raw material components of sponge dressing include graphene oxide/benefit
Cacaine inclusion compound, and a concentration of 5~20mg/mL of graphene oxide/lidocaine inclusion compound.
Preferably, the raw material components of sponge dressing further include polyvinyl alcohol, foaming agent, catalyst and crosslinking agent.
Preferably, the ratio of polyvinyl alcohol, graphene oxide/lidocaine inclusion compound, foaming agent, catalyst and crosslinking agent
It is followed successively by (20~500) g：(1~20) mL：(0.01~15) g：(10~400) mL：(10~400) mL.
Preferably, foaming agent selects OP-10 or TX-100, and catalyst selects sulfuric acid or hydrochloric acid, crosslinking agent select formaldehyde or
Geniposide.
Second aspect, the present invention provide a kind of preparation method of sponge dressing, include the following steps：S101：By polyethylene
Alcohol is added in deionized water, and heating stirring is cooled to room temperature to being completely dissolved, obtains polyvinyl alcohol water solution later；S102：
Graphene oxide/lidocaine inclusion compound is added in polyvinyl alcohol water solution, stirs evenly, obtains graphene oxide/benefit card
Because of alkene polyvinyl alcohol blending liquid；S103：Foaming agent is added in graphene oxide/lidocaine alkene polyvinyl alcohol blending liquid, fills
Divide and stirs evenly；S104：Catalyst is added in the solution that S103 is obtained, preset time is stirred under preset temperature；S105：
The reaction was continued after addition crosslinking agent in the product that S104 is obtained, and by reaction product baking molding, is compressed and washed later to neutrality, obtains sea
Continuous dressing.
Preferably, further include step after S105：Sponge dressing is cut, later with clamping plate by sponge pressure for 1~
2mm, the vacuum compression at 30~50 DEG C.
Preferably, in S101, the addition of deionized water is 5~10 times of polyvinyl alcohol quality, and preferably 7 times；S104
In, preset temperature is 25~30 DEG C, and preset time is 3~5min；In S105, the time that the reaction was continued is 20~25min, baking
Molding temperature is 50~70 DEG C.
Preferably, the preparation method of graphene oxide/lidocaine inclusion compound includes the following steps：S201：Stone will be aoxidized
Black alkene is added in deionized water and is ultrasonically treated, and obtains graphene oxide dispersion；S202：Lidocaine hydrochloride is used into second
Alcohol is dissolved, and graphene oxide dispersion is added later and is ultrasonically treated；S203：The solution that S202 is obtained is continued to stir
It mixes, adjusts pH value later to 6 hereinafter, obtaining graphene oxide/lidocaine inclusion compound.
Preferably, the preparation method of graphene oxide includes the following steps：S301：It uses graphite for raw material, mixing is added
Potassium permanganate is added in acid later, in being reacted under confined conditions；Wherein, mixed acid selects sulfuric acid and phosphoric acid；S302：It will
The reaction product that S301 is obtained is cooled to room temperature, and hydrogen peroxide is added under the conditions of ice-water bath later, until glassy yellow is presented in solution
After carry out centrifugal treating；S303：Solid phase after centrifugal treating is washed, until supernatant liquor pH value reaches neutral, later
It collects solid product and carries out frozen dried, obtain graphene oxide.
Technical solution provided by the invention has following advantageous effect：
(1) applicant has found by many experiments：Medical sponge dressing provided by the invention combines graphene oxide, profit
The excellent properties such as Ka Duoyin and polyvinyl alcohol have quick imbibition, a large amount of imbibitions, lock big moisture, antibacterial, analgesia, flexibility
And elasticity it is high the advantages that, patient can be treated rapidly and be wound skin, the great pain that the surface of a wound is brought is mitigated.In addition, the present invention cures
It is cheap with sponge dressing simple production process, it easily realizes industrialized production, is with a wide range of applications.
(2) as a kind of superfine medical sponge dressing, raw material selection and proportioning are scientific and reasonable for dressing of the present invention；Its
In, the active oxygen-containing functional group of graphene surface determines it with active charge affinity, and huge specific surface area can be with
Many drugs are loaded, can achieve the effect that release for a long time slow.Lidocaine or its salt use most extensive as current local anaesthesia
Antalgesic, can be used for the surgical anesthesias such as surface anesthesia, infiltration anesthesia, peridural anesthesia, burn etc. the surface of a wound application in profit
More cacaines significantly reduce the feeling of pain of patient.
(3) this nano material of graphene oxide is added in the present invention in PVA sponges, improves the imbibition of PVA sponge materials
Amount, graphene oxide have the two-dimensional sheet material of cellular single layer structure, large specific surface area, excellent physical and chemical performance and good life
Object compatibility.In addition, the addition of stannic oxide/graphene nano material can provide a payload space for lidocaine, in turn
Control the permanent efficient release of lidocaine.
The additional aspect and advantage of the present invention will be set forth in part in the description, and will partly become from the following description
Obviously, or practice through the invention is recognized.
Description of the drawings
Fig. 1 is the flow diagram of medical dressing preparation method in the embodiment of the present invention.
Specific implementation mode
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation describes.The following examples are only intended to illustrate the technical solution of the present invention more clearly, therefore is intended only as example, without
It can be limited the scope of the invention with this.
Experimental method in following embodiments is unless otherwise specified conventional method.Examination as used in the following examples
Material is tested, is to be commercially available from conventional reagent shop unless otherwise specified.Quantitative test in following embodiment, is all provided with
Three repeated experiments are set, data are the average value or mean+SD of three repeated experiments.
The present invention provides a kind of sponge dressing, and raw material components include 20~500g polyvinyl alcohol, 1~20mL graphite oxides
Alkene/lidocaine inclusion compound, 0.01~15g foaming agents, 10~400mL catalyst and 10~400mL crosslinking agents, and graphite oxide
A concentration of 5~20mg/mL of alkene/lidocaine inclusion compound.
In addition, for the sponge dressing of the present invention, applicant specially provides preparation method, as shown in Figure 1, including following
Step：
S101：Polyvinyl alcohol being added in the deionized water of 5~10 times of amounts, gradually stirring is warming up to 90 DEG C and is completely dissolved,
It is cooled to room temperature later, obtains polyvinyl alcohol water solution.
S102：Graphene oxide/lidocaine inclusion compound is added in polyvinyl alcohol water solution, stirs evenly, obtains oxygen
Graphite alkene/lidocaine alkene polyvinyl alcohol blending liquid.
S103：Foaming agent is added in graphene oxide/lidocaine alkene polyvinyl alcohol blending liquid, stirs.
S104：Catalyst is added in the solution that S103 is obtained, 3~5min is stirred at 25~30 DEG C.
S105：The reaction was continued 20~25min after crosslinking agent is added in the product that S104 is obtained, by reaction product in 50~
Baking molding at 70 DEG C compresses and washes later to neutrality, obtains sponge dressing.
S106：Sponge dressing is cut, is later 1~2mm, the vacuum pressure at 30~50 DEG C by sponge pressure with clamping plate
Contracting.
Wherein, the preparation method of graphene oxide/lidocaine inclusion compound includes the following steps：S201：By graphite oxide
Alkene is added in deionized water and is ultrasonically treated, and obtains graphene oxide dispersion；S202：Lidocaine hydrochloride is used into ethyl alcohol
It is dissolved, graphene oxide dispersion is added later and is ultrasonically treated；S203：The solution that S202 is obtained is continued to stir
It mixes, adjusts pH value later to 6 hereinafter, obtaining graphene oxide/lidocaine inclusion compound.
The preparation method of graphene oxide includes the following steps：S301：It uses graphite for raw material, mixed acid is added, later
Potassium permanganate is added, in being reacted under confined conditions；Wherein, mixed acid selects sulfuric acid and phosphoric acid；S302：S301 is obtained
Reaction product is cooled to room temperature, and hydrogen peroxide is added under the conditions of ice-water bath later, until solution is centrifuged after glassy yellow is presented
Processing；S303：Solid phase after centrifugal treating is washed, until supernatant liquor pH value reaches neutral, collects solid phase production later
Object simultaneously carries out frozen dried, obtains graphene oxide.
The present invention is further explained in the light of specific embodiments.
Embodiment one
The present embodiment provides a kind of preparation methods of graphene oxide, include the following steps：Graphite is prepared into oxidation stone
Black alkene, the sulfuric acid and phosphoric acid mixed acid that 3g graphite powders are put into 500mL single-necked flasks, 300mL is added later, is slowly added to Gao Meng
Sour potassium is sealed with sealed membrane at 50 DEG C, is stirred to react 15h, uses 400mL ice-water baths after being cooled to room temperature, and in ice-water bath condition
The lower hydrogen peroxide that mass percentage concentration is added and is 30%, by being added soon and slowly until glassy yellow, low-speed centrifugal is presented in solution；It will be from
Heart product moves on in beaker, and salt acid centrifuging is added and washes 2 times, ethyl alcohol centrifuge washing is added 2 times, and secondary deionized water washs 6 times directly
Reach neutral to supernatant liquor pH value, is graphene oxide by product progress frozen dried.
Embodiment two
Based on the graphene oxide that embodiment one is prepared, the present embodiment provides a kind of graphene oxide/lidocaines
The preparation method of inclusion compound, includes the following steps：
It takes 50mg graphene oxides that 25mL deionized waters are added and is ultrasonically treated 30min, graphene oxide solution is shifted
To 100mL round-bottomed flasks, graphene oxide dispersion is obtained.Lidocaine hydrochloride 200mg is weighed, is dissolved in 3mL absolute ethyl alcohols,
Then it is 400W, frequency 40kHz that 7mL graphene oxide dispersions, ultrasonic 30min, and ultrasonic power, which is added,；It stirs overnight later
It mixes, adjusts pH value to 6 hereinafter, graphene oxide/lidocaine inclusion compound of a concentration of 20mg/mL is made；It is subsequently placed in 4 DEG C of ice
It is spare in case.
The graphene oxide that embodiment two is prepared/lidocaine inclusion compound is used for the preparation process of sponge dressing
In, specifically include following embodiment：
Embodiment three
The present embodiment provides a kind of preparation methods of sponge dressing, include the following steps：
S101：30g polyvinyl alcohol is added in 210g deionized waters, gradually stirring is warming up to 90 DEG C and is completely dissolved, then
It is cooled to room temperature, obtains polyvinyl alcohol water solution.
S102：Graphene oxide/lidocaine hydrochloride inclusion of the 20mg/mL of 3mL is added in polyvinyl alcohol water solution
Object stirs evenly, and obtains graphene oxide/lidocaine alkene polyvinyl alcohol blending liquid.
S103：Foaming agent is added in graphene oxide/lidocaine alkene polyvinyl alcohol blending liquid, stirs.
S104：Catalyst is added in the solution that S103 is obtained, uniform stirring 5min keeps temperature to stablize at 30 DEG C.
S105：The reaction was continued 25min after crosslinking agent is added in the product that S104 is obtained, reaction product is poured into grinding tool
Box, 50 DEG C of baking moldings, compresses and washes later to neutrality, obtains sponge dressing.
S106：The sponge dressing that S105 is obtained is cut, is later 2mm by sponge pressure with clamping plate, it is true at 45 DEG C
Pneumatics contracts, and obtains final product compressed sponge dressing.
Example IV
The present embodiment provides a kind of preparation methods of sponge dressing, include the following steps：
S101：80g polyvinyl alcohol is added in 560g deionized waters, gradually stirring is warming up to 90 DEG C and is completely dissolved, then
It is cooled to room temperature, obtains polyvinyl alcohol water solution.
S102：Graphene oxide/lidocaine hydrochloride inclusion of the 20mg/mL of 12mL is added in polyvinyl alcohol water solution
Object stirs evenly, and obtains graphene oxide/lidocaine alkene polyvinyl alcohol blending liquid.
S103：Foaming agent is added in graphene oxide/lidocaine alkene polyvinyl alcohol blending liquid, stirs.
S104：Catalyst is added in the solution that S103 is obtained, uniform stirring 5min keeps temperature to stablize at 30 DEG C.
S105：The reaction was continued 25min after crosslinking agent is added in the product that S104 is obtained, reaction product is poured into grinding tool
Box, 50 DEG C of baking moldings, compresses and washes later to neutrality, obtains sponge dressing.
S106：The sponge dressing that S105 is obtained is cut, is later 2mm by sponge pressure with clamping plate, it is true at 45 DEG C
Pneumatics contracts, and obtains final product compressed sponge dressing.
Embodiment five
The present embodiment provides a kind of preparation methods of sponge dressing, include the following steps：
S101：300g polyvinyl alcohol is added in 2100g deionized waters, gradually stirring is warming up to 90 DEG C and is completely dissolved, so
Postcooling obtains polyvinyl alcohol water solution to room temperature.
S102：Graphene oxide/lidocaine hydrochloride inclusion of the 20mg/mL of 60mL is added in polyvinyl alcohol water solution
Object stirs evenly, and obtains graphene oxide/lidocaine alkene polyvinyl alcohol blending liquid.
S103：Foaming agent is added in graphene oxide/lidocaine alkene polyvinyl alcohol blending liquid, stirs.
S104：Catalyst is added in the solution that S103 is obtained, uniform stirring 5min keeps temperature to stablize at 30 DEG C.
S105：The reaction was continued 25min after crosslinking agent is added in the product that S104 is obtained, reaction product is poured into grinding tool
Box, 50 DEG C of baking moldings, compresses and washes later to neutrality, obtains sponge dressing.
S106：The sponge dressing that S105 is obtained is cut, is later 2mm by sponge pressure with clamping plate, it is true at 45 DEG C
Pneumatics contracts, and obtains final product compressed sponge dressing.
It should be noted that the case where being enumerated in addition to above-described embodiment one to embodiment five, selects other preparation methods
Parameter is also feasible.
Medical sponge dressing provided by the invention combines the superiority such as graphene oxide, Li Kaduoyin and polyvinyl alcohol
Can, have many advantages, such as quick imbibition, a large amount of imbibitions, lock moisture big, antibacterial, analgesia, flexibility and elastic high, can treat rapidly
Patient is wound skin, mitigates the great pain that the surface of a wound is brought.In addition, medical sponge dressing simple production process of the present invention, price
It is cheap, it easily realizes industrialized production, is with a wide range of applications.
It should be noted that unless otherwise indicated, technical term or scientific terminology used in this application should be this hair
The ordinary meaning that bright one of ordinary skill in the art are understood.Unless specifically stated otherwise, it otherwise illustrates in these embodiments
Component and opposite step, numerical expression and the numerical value of step are not limit the scope of the invention.It is illustrated and described herein
In all examples, unless otherwise prescribed, any occurrence should be construed as merely illustrative, not as limitation, because
This, other examples of exemplary embodiment can have different values.
Finally it should be noted that：The above embodiments are only used to illustrate the technical solution of the present invention., rather than its limitations；To the greatest extent
Present invention has been described in detail with reference to the aforementioned embodiments for pipe, it will be understood by those of ordinary skill in the art that：Its according to
So can with technical scheme described in the above embodiments is modified, either to which part or all technical features into
Row equivalent replacement；And these modifications or replacements, various embodiments of the present invention technology that it does not separate the essence of the corresponding technical solution
The range of scheme should all cover in protection scope of the present invention.
Claims (9)
1. a kind of sponge dressing, it is characterised in that：
The raw material components of the sponge dressing include graphene oxide/lidocaine inclusion compound, and the graphene oxide/benefit
A concentration of 5~20mg/mL of cacaine inclusion compound.
2. sponge dressing according to claim 1, it is characterised in that：
The raw material components of the sponge dressing further include polyvinyl alcohol, foaming agent, catalyst and crosslinking agent.
3. sponge dressing according to claim 2, it is characterised in that：
The polyvinyl alcohol, the graphene oxide/lidocaine inclusion compound, the foaming agent, the catalyst and the friendship
The usage ratio of connection agent is followed successively by (20~500) g：(1~20) mL：(0.01~15) g：(10~400) mL：(10~400) mL.
4. sponge dressing according to claim 2 or 3, it is characterised in that：
The catalyst selects sulfuric acid or hydrochloric acid, the crosslinking agent to select formaldehyde or Geniposide.
5. the preparation method of any one of claim 2~4 sponge dressing, which is characterized in that include the following steps：
S101：Polyvinyl alcohol is added in deionized water, heating stirring is cooled to room temperature to being completely dissolved, obtains poly- second later
Enol aqueous solution；
S102：Graphene oxide/lidocaine inclusion compound is added in the polyvinyl alcohol water solution, stirs evenly, obtains oxygen
Graphite alkene/lidocaine alkene polyvinyl alcohol blending liquid；
S103：Foaming agent is added in the graphene oxide/lidocaine alkene polyvinyl alcohol blending liquid, stirs；
S104：Catalyst is added in the solution that the S103 is obtained, preset time is stirred under preset temperature；
S105：The reaction was continued after addition crosslinking agent in the product that the S104 is obtained, and reaction product baking molding is pressed later
It is washed till neutrality, obtains sponge dressing.
6. the preparation method of sponge dressing according to claim 5, it is characterised in that：
Further include step S106 after the S105：Sponge dressing is cut, is later 1~2mm by sponge pressure with clamping plate,
The vacuum compression at 30~50 DEG C.
7. the preparation method of sponge dressing according to claim 5, it is characterised in that：
In the S101, the addition of the deionized water is 5~10 times of the polyvinyl alcohol quality, and preferably 7 times；
In the S104, the preset temperature is 25~30 DEG C, and the preset time is 3~5min；
In the S105, the time that the reaction was continued is 20~25min, and the temperature of the baking molding is 50~70 DEG C.
8. the preparation method of sponge dressing according to claim 5, it is characterised in that：
The preparation method of the graphene oxide/lidocaine inclusion compound includes the following steps：
S201：It adds graphene oxide into deionized water and is ultrasonically treated, obtain graphene oxide dispersion；
S202：Lidocaine hydrochloride is dissolved using ethyl alcohol, the graphene oxide dispersion is added later and is surpassed
Sonication；
S203：The obtained solution of the S202 is continued to stir, adjusts pH value later to 6 hereinafter, obtaining graphene oxide/benefit
Cacaine inclusion compound.
9. the preparation method of sponge dressing according to claim 8, it is characterised in that：
The preparation method of the graphene oxide includes the following steps：
S301：It uses graphite for raw material, mixed acid is added, potassium permanganate is added later, in being reacted under confined conditions；Its
In, the mixed acid selects sulfuric acid and phosphoric acid；
S302：The obtained reaction products of the S301 are cooled to room temperature, hydrogen peroxide is added under the conditions of ice-water bath later, until
Solution carries out centrifugal treating after glassy yellow is presented；
S303：Solid phase after the centrifugal treating is washed, until supernatant liquor pH value reaches neutral, collects solid phase later
Product simultaneously carries out frozen dried, obtains graphene oxide.
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