CN104888267A - Medicinal bleeding-stopping spandex fiber fabric and preparation method thereof - Google Patents
Medicinal bleeding-stopping spandex fiber fabric and preparation method thereof Download PDFInfo
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- CN104888267A CN104888267A CN201510270670.XA CN201510270670A CN104888267A CN 104888267 A CN104888267 A CN 104888267A CN 201510270670 A CN201510270670 A CN 201510270670A CN 104888267 A CN104888267 A CN 104888267A
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- spandex fibre
- bleeding
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Abstract
The invention discloses a medicinal bleeding-stopping spandex fiber fabric and a preparation method thereof. The problem that a bleeding-stopping material in the prior art is poor in bleeding-stopping effect is solved. According to the medicinal bleeding-stopping spandex fiber fabric, spandex fibers are woven into a fabric, and inorganic bleeding-stopping powder and a dispersing agent are added into the spandex fibers. According to the medicinal bleeding-stopping spandex fiber fabric disclosed by the invention, the powder with the bleeding-stopping effect is added into the spandex fibers, and the dispersing agent is added, so that the bleeding-stopping powder is sufficiently and uniformly mixed into the spandex fibers, and the effect of promoting coagulation of the woven fabric is good; the selected bleeding-stopping powder can resist a relatively high spinning temperature, and the spandex has the advantages of being good in elastic recovery and high in elongation at break, so that the prepared bleeding-stopping spandex can be widely applied to the medicinal field.
Description
Technical field
The present invention relates to hemostasis medical material field, refer to a kind of medical hemostatic spandex fibre fabric and preparation method thereof especially.
Background technology
Human or animal is because of wound or injured thus cause hemorrhage, when injured lighter, can stop hemorrhage by the natural hemostatic mechanism of health, in some cases, basic first aid can be used to stop blood flow and assist wound healing, as by wound apply continuous pressure to stop the blood flow in patient, this thrombin can be collected at wound site place and formed condense clot to stop blood flow.And the hemostasis of massive hemorrhage is the difficult problem that people perplex always, the problem often run in massive hemorrhage Ye Shi medical institutions, natural disaster, vehicle accident, accident.The first aid means of massive hemorrhage are all oppressed by physics traditionally, assist again and stop blooding with physical materials such as binder, gauze, rubber strips, these materials are adopt spraying, coating or direct mode of soaking to stick hemorrhage at gauze or fabric mostly, the amount of sticking of hemorrhage is limited, and easily come off, result also in the reduction of coagulant effect and the difficulty of subsequent treatment, reduce haemostatic effect.
Summary of the invention
The present invention proposes a kind of medical hemostatic spandex fibre fabric and preparation method thereof, solves the problem of hemostatic material haemostatic effect difference in prior art.
Technical scheme of the present invention is achieved in that a kind of medical hemostatic spandex fibre fabric, adopts spandex fibre to be woven into fabric, and add inorganic hemostatic powder, dispersant in described spandex fibre.
As preferred technical scheme, the addition of described inorganic hemostatic powder is equivalent to 0.1% ~ 6% of described spandex fibre weight.
As preferred technical scheme, described inorganic hemostatic powder is one or more in kieselguhr, montorillonite clay, zeolite, bio-vitric and halloysite nanotubes.
As preferred technical scheme, the weight ratio of described dispersant and described inorganic hemostatic powder is 1:10 ~ 1:2.
As preferred technical scheme, described dispersant is one or more in fatty acid, soap.
The present invention proposes again a kind of preparation method of medical hemostatic spandex fibre fabric, comprises the following steps:
1) polyurethane-urea stock solution is prepared;
2) described inorganic hemostatic powder, described dispersant are ground in dimethylacetamide solvent, obtain hemostasis serosity;
3) described polyurethane-urea stock solution, described hemostasis serosity are inserted in reaction vessel simultaneously, obtain spandex fibre by dry-spinning process, be finally woven into spandex fibre fabric.
As preferred technical scheme, step 2) in after grinding the particle diameter of described hemostasis powder be less than 10 μm.
The present invention adds the powder with haemostatic effect in spandex fibre, and dispersant in addition, make stop blooding powder full and uniform incorporate in spandex fibre, and then the fabric of braiding is thromboplastic effective, the hemostasis powder selected can resist higher spinning temperature, spandex has the advantage that elastic return is good, elongation at break is high, and so obtained hemostasis spandex can be widely used in medical field.
Accompanying drawing explanation
In order to be illustrated more clearly in the embodiment of the present invention or technical scheme of the prior art, be briefly described to the accompanying drawing used required in embodiment or description of the prior art below, apparently, accompanying drawing in the following describes is only some embodiments of the present invention, for those of ordinary skill in the art, under the prerequisite not paying creative work, other accompanying drawing can also be obtained according to these accompanying drawings.
Fig. 1 is process flow diagram of the present invention.
Detailed description of the invention
Below in conjunction with the accompanying drawing in the embodiment of the present invention, be clearly and completely described the technical scheme in the embodiment of the present invention, obviously, described embodiment is only the present invention's part embodiment, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, belong to the scope of protection of the invention.
A kind of medical hemostatic spandex fibre fabric, adopts spandex fibre to be woven into fabric, and add inorganic hemostatic powder, dispersant in described spandex fibre.
As preferred technical scheme, the addition of described inorganic hemostatic powder is equivalent to 0.1% ~ 6% of described spandex fibre weight.
As preferred technical scheme, described inorganic hemostatic powder is one or more in kieselguhr, montorillonite clay, zeolite, bio-vitric and halloysite nanotubes.
As preferred technical scheme, the weight ratio of described dispersant and described inorganic hemostatic powder is 1:10 ~ 1:2.
As preferred technical scheme, described dispersant is one or more in fatty acid, soap.
As shown in Figure 1, the present invention proposes again a kind of preparation method of medical hemostatic spandex fibre fabric, comprises the following steps:
1) polyurethane-urea stock solution is prepared;
2) described inorganic hemostatic powder, described dispersant are ground in dimethylacetamide solvent, obtain hemostasis serosity;
3) described polyurethane-urea stock solution, described hemostasis serosity are inserted in reaction vessel simultaneously, obtain spandex fibre by dry-spinning process, be finally woven into spandex fibre fabric.
As preferred technical scheme, step 2) in after grinding the particle diameter of described hemostasis powder be less than 10 μm.
Embodiment one
A preparation method for medical hemostatic spandex fibre fabric, comprises the following steps:
1) polyurethane-urea stock solution is prepared: get 17Kg PTMG, 72.4Kg diphenyl methane-4,4 ' vulcabond is placed in reactor, 120min is reacted at 86 DEG C, obtain isocyanate-terminated prepolymer, after add 127.86Kg dimethylacetamide solvent, stir, dissolve prepolymer and form solution, add again and be dissolved in by 1.641Kg ethylenediamine, 0.306Kg diethylamine the amine mixed solution formed in 36.984Kg dimethyl acetylamide, carry out chain extending reaction and chain termination reaction, to obtain final product.
2) 91.5g zeolite, 9.15g magnesium stearate are ground in 187g dimethylacetamide solvent, wherein the weight ratio of magnesium stearate and zeolite is 1:10, obtains hemostasis serosity, and after grinding, the particle diameter of zeolite is less than 10 μm;
3) polyurethane-urea stock solution, hemostasis serosity are inserted in reaction vessel simultaneously, 40D spandex fibre is obtained by dry-spinning process, zeolite addition is equivalent to 0.1% of spandex fibre weight, is finally woven into spandex fibre fabric, and circular knitting machine selected by the machine of braiding.
Embodiment two
A preparation method for medical hemostatic spandex fibre fabric, comprises the following steps:
1) polyurethane-urea stock solution is prepared: get 17Kg PTMG, 72.4Kg diphenyl methane-4,4 ' vulcabond is placed in reactor, 120min is reacted at 86 DEG C, obtain isocyanate-terminated prepolymer, after add 127.86Kg dimethylacetamide solvent, stir, dissolve prepolymer and form solution, add again and be dissolved in by 1.641Kg ethylenediamine, 0.306Kg diethylamine the amine mixed solution formed in 36.984Kg dimethyl acetylamide, carry out chain extending reaction and chain termination reaction, to obtain final product.
2) 924.5g bio-vitric, 154.1g calcium stearate are ground in 2.004Kg dimethylacetamide solvent, wherein the weight ratio of calcium stearate and bio-vitric is 1:6, obtains hemostasis serosity, and the particle diameter of grinding artifact glass is less than 10 μm;
3) polyurethane-urea stock solution, hemostasis serosity are inserted in reaction vessel simultaneously, 40D spandex fibre is obtained by dry-spinning process, bio-vitric addition is equivalent to 1% of spandex fibre weight, is finally woven into spandex fibre fabric, and circular knitting machine selected by the machine of braiding.
Embodiment three
A preparation method for medical hemostatic spandex fibre fabric, comprises the following steps:
1) polyurethane-urea stock solution is prepared: get 17Kg PTMG, 72.4Kg diphenyl methane-4,4 ' vulcabond is placed in reactor, 120min is reacted at 86 DEG C, obtain isocyanate-terminated prepolymer, after add 127.86Kg dimethylacetamide solvent, stir, dissolve prepolymer and form solution, add again and be dissolved in by 1.641Kg ethylenediamine, 0.306Kg diethylamine the amine mixed solution formed in 36.984Kg dimethyl acetylamide, carry out chain extending reaction and chain termination reaction, to obtain final product.
2) 3.8464Kg halloysite nanotubes, 961.6g stearic acid are ground in 8.929Kg dimethylacetamide solvent, wherein the weight ratio of stearic acid and halloysite nanotubes is 1:4, obtains hemostasis serosity, and after grinding, the particle diameter of halloysite nanotubes is less than 10 μm;
3) polyurethane-urea stock solution, hemostasis serosity are inserted in reaction vessel simultaneously, 40D spandex fibre is obtained by dry-spinning process, halloysite nanotubes addition is equivalent to 4% of spandex fibre weight, is finally woven into spandex fibre fabric, and circular knitting machine selected by the machine of braiding.
Embodiment four
A preparation method for medical hemostatic spandex fibre fabric, comprises the following steps:
1) polyurethane-urea stock solution is prepared: get 17Kg PTMG, 72.4Kg diphenyl methane-4,4 ' vulcabond is placed in reactor, 120min is reacted at 86 DEG C, obtain isocyanate-terminated prepolymer, after add 127.86Kg dimethylacetamide solvent, stir, dissolve prepolymer and form solution, add again and be dissolved in by 1.641Kg ethylenediamine, 0.306Kg diethylamine the amine mixed solution formed in 36.984Kg dimethyl acetylamide, carry out chain extending reaction and chain termination reaction, to obtain final product.
2) 6.023Kg zeolite and the mixing hemostasis powder of halloysite nanotubes, the stearic acid of 3.011Kg are ground in 16.778Kg dimethylacetamide solvent, wherein stearic acid is 1:2 with the weight ratio mixing the powder that stops blooding, must be stopped blooding serosity, and after grinding, the particle diameter of mixing hemostasis powder is less than 10 μm;
3) polyurethane-urea stock solution, hemostasis serosity are inserted in reaction vessel simultaneously, 40D spandex fibre is obtained by dry-spinning process, mixing hemostasis powder addition is equivalent to 6% of spandex fibre weight, and be finally woven into spandex fibre fabric, circular knitting machine selected by the machine of braiding.
Hemostasis zoopery
With rabbit ear artery hemostasis for model, design matched group, matched group adopts containing the spandex fabric of inorganic hemostatic powder, dispersant, and the spandex fabric of matched group, embodiment one group, embodiment two groups, embodiment three groups, embodiment four groups is cut into 2.0cm × 2.0cm size, sterilizing, for subsequent use.Test material is sticked in rabbit ear wound surface, to final hemostasis completely, record bleeding stopping period.Experimental result is as following table 1:
Table 1
Can be found out by upper table 1, with the addition of inorganic hemostatic powder, dispersant the bleeding stopping period of embodiment one, two, three, four groups obviously shorter, and haemostatic effect is good.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (7)
1. a medical hemostatic spandex fibre fabric, is characterized in that:
Adopt spandex fibre to be woven into fabric, and add inorganic hemostatic powder, dispersant in described spandex fibre.
2. a kind of medical hemostatic spandex fibre fabric as claimed in claim 1, is characterized in that:
The addition of described inorganic hemostatic powder is equivalent to 0.1% ~ 6% of described spandex fibre weight.
3. a kind of medical hemostatic spandex fibre fabric as claimed in claim 1, is characterized in that:
Described inorganic hemostatic powder is one or more in kieselguhr, montorillonite clay, zeolite, bio-vitric and halloysite nanotubes.
4. a kind of medical hemostatic spandex fibre fabric as claimed in claim 1, is characterized in that:
The weight ratio of described dispersant and described inorganic hemostatic powder is 1:10 ~ 1:2.
5. a kind of medical hemostatic spandex fibre fabric as claimed in claim 1, is characterized in that:
Described dispersant is one or more in fatty acid, soap.
6. prepare the method for a kind of medical hemostatic spandex fibre fabric as claimed in claim 1, it is characterized in that, comprise the following steps:
1) polyurethane-urea stock solution is prepared;
2) described inorganic hemostatic powder, described dispersant are ground in dimethylacetamide solvent, obtain hemostasis serosity;
3) described polyurethane-urea stock solution, described hemostasis serosity are inserted in reaction vessel simultaneously, obtain spandex fibre by dry-spinning process, be finally woven into spandex fibre fabric.
7. the preparation method of a kind of medical hemostatic spandex fibre fabric as claimed in claim 6, is characterized in that:
Step 2) in after grinding the particle diameter of described inorganic hemostatic powder be less than 10 μm.
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106435816A (en) * | 2016-09-21 | 2017-02-22 | 东华大学 | Preparation method of cellulose/bioglass composite fiber |
| CN108030952A (en) * | 2017-12-25 | 2018-05-15 | 陈益德 | A kind of new bio fiber hemostatic material and preparation method thereof |
| WO2019242390A1 (en) | 2018-06-18 | 2019-12-26 | 浙江大学 | Molecular sieve/fiber composite material and preparation method therefor |
| WO2019242391A1 (en) | 2018-06-18 | 2019-12-26 | 浙江大学 | Hemostatic complex and preparation method therefor |
| CN110621354A (en) * | 2017-07-21 | 2019-12-27 | 矿物快速护理有限公司 | Novel wound dressing for hemostasis |
| WO2020108669A1 (en) | 2018-12-01 | 2020-06-04 | 浙江大学 | Trypsin-containing hemostatic fabric and preparation method therefor |
| CN112755967A (en) * | 2020-12-15 | 2021-05-07 | 武汉大学 | Chitin nano fiber porous composite microsphere blood ammonia adsorbent, preparation method and application thereof |
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| US20070154510A1 (en) * | 2005-12-30 | 2007-07-05 | Wilcher Steve A | Adsorbent-Containing Hemostatic Devices |
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106435816A (en) * | 2016-09-21 | 2017-02-22 | 东华大学 | Preparation method of cellulose/bioglass composite fiber |
| CN106435816B (en) * | 2016-09-21 | 2018-04-17 | 东华大学 | A kind of preparation method of cellulose/bio-vitric composite fibre |
| CN110621354A (en) * | 2017-07-21 | 2019-12-27 | 矿物快速护理有限公司 | Novel wound dressing for hemostasis |
| CN110621354B (en) * | 2017-07-21 | 2023-03-10 | 矿物快速护理有限公司 | Novel wound dressing for hemostasis |
| CN108030952A (en) * | 2017-12-25 | 2018-05-15 | 陈益德 | A kind of new bio fiber hemostatic material and preparation method thereof |
| WO2019242390A1 (en) | 2018-06-18 | 2019-12-26 | 浙江大学 | Molecular sieve/fiber composite material and preparation method therefor |
| WO2019242391A1 (en) | 2018-06-18 | 2019-12-26 | 浙江大学 | Hemostatic complex and preparation method therefor |
| US11154512B2 (en) | 2018-06-18 | 2021-10-26 | Hangzhou Zeo-Innov Life Technology Co., Ltd | Hemostatic compound and preparation method thereof |
| WO2020108669A1 (en) | 2018-12-01 | 2020-06-04 | 浙江大学 | Trypsin-containing hemostatic fabric and preparation method therefor |
| CN112755967A (en) * | 2020-12-15 | 2021-05-07 | 武汉大学 | Chitin nano fiber porous composite microsphere blood ammonia adsorbent, preparation method and application thereof |
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