CN108404108A - 一种复合玉米低聚肽胶囊及其制备方法 - Google Patents
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Abstract
本发明属于低聚肽粉加工技术领域，具体地说是一种复合玉米低聚肽胶囊及其制备方法。其原料组成成分及其重量份数比为：玉米低聚肽粉30~40份、甜橙粉15~20份、木糖醇15~18份、茶多酚12~16份、茶氨酸13~15份、壳寡糖12~15份、维生素E3~6份、柑橘油12~16份、蔗糖酯10~12份、玉竹提取物8~12份、鱼腥草提取物6~8份、酢浆草提取物6~8份、茜草提取物6~8份、纯水适量。制备方法为：从原料中分别制备玉竹提取物、鱼腥草提取物、酢浆草提取物、茜草提取物，再将原料制备成微乳液，最后将微乳液制备成胶囊即可。本发明制备得到的复合玉米低聚肽胶囊内服或者外用，作用效果好，有利于人体健康。
Description
技术领域
本发明属于低聚肽粉加工技术领域，具体地说是一种复合玉米低聚肽胶囊及其制备方法。
背景技术
低聚肽又称寡肽，一般由2~6个氨基酸组成。研究表明，低聚肽可以被小肠直接吸收。低聚肽在动物体内与蛋白质、氨基酸相比更容易被吸收，而且低聚肽具有独特的生理功能和理化性能，这是原蛋白质或组成氨基酸所不具备的。目前，人们对低聚肽的研究主要为大豆、鱼皮、畜骨等原料中。按原料来源可将低聚肽分为动物源低聚肽、植物源低聚肽和微生物源低聚肽，制备得到的低聚肽可应用于医药、化妆品、保健品等领域中。
玉米低聚肽粉是以玉米蛋白粉为原料，经过调浆、蛋白酶解、分离、过滤、喷雾干燥等工艺生产而成的。玉米多聚肽粉是一种新资源产品，富含丙氨酸、亮氨酸、谷氨酸和脯氨酸等，其特殊的氨基酸组成和连接方式赋予了玉米低聚肽多种生物活性。玉米低聚肽可促进乙醇代谢具有醒酒护肝作用，玉米低聚肽具有抑制血管紧张素转换酶(ACE)作用可应用于降血压，此外，玉米低聚肽还具有生理功能，如增强增强免疫及增强运动能力、抗过敏和抗氧化性等。玉米低聚肽含有丰富的保健功能和优良的加工性能，作为一种新功能食品原料而备受业界关注，应用前景广阔。
中国专利申请号：CN201210557156.0，专利名称：一种玉米低聚肽粉含片及其制备方法。该专利公开了一种玉米低聚肽粉含片及其制备方法，含片按重量份计包括以下组分：玉米低聚肽粉 25~35、枳椇提取物10~20、葛根提取物5~15、陈皮提取物0.5~5、砂仁提取物0.5~5、生姜提取物0.5~5、茯苓提取物0.5~5、食品添加剂0.1~0.5、薄荷提取物1.5~2.5、白砂糖35~45、抗结剂0.1~1；其制备方法包括原料粉碎、制软料、湿法制粒、干燥、过筛整粒、添加抗结剂、压片、包装。该发明营养保健功能全面，兼具护肝解酒、健脾和胃、降压降血脂之营养保健功效，适口性好，安全无毒，该发明制备方法简单易行，成本低廉。
中国专利申请号：CN201510422658.6，专利名称：一种玉米低聚肽粉和中药复合解酒饮料的制备方法。该产品以玉米低聚肽粉为主要原料，辅以葛根、葛花、佛手、陈皮、枳椇子、茯苓六种药食同源的食材，并添加牛磺酸、维生素C、蜂蜜等，配置成口味甘甜、清爽的解酒饮料。该发明所述的解酒饮料能够显著促进体内酒精代谢，且能够快速有效地醒酒，并缓解醉酒后肠胃不适、头晕头疼等症状，效果显著优于现有市售解酒饮料。
对于内服和外用的药物，中国专利申请号：201610542478.6，专利名称公开了一种天然细胞修复剂及其制备方法。该专利采用的原料组分包括粉剂，所述粉剂包括：羊胎素1-8重量份、深海鱼皮胶原蛋白肽1-8重量份、蜂蜜粉1-7重量份、蛋清粉0.7-6重量份、苹果多酚0.5-5重量份、谷胱甘肽0.2-1重量份、辅酶Q10 0.2-1重量份和卵磷脂1-8重量份。所述天然细胞修复剂的制备方法为，将以上各原料组分干燥、粉碎、均匀混合，分装，即可。所述天然细胞修复剂采用具有高生物活性的天然原料组分，外用时能够增加细胞活性，改善皮肤弹性，均匀肤色，防止黑色素生成，延缓皱纹产生，美白除皱；内服时能够强壮心血管系统，清除自由基，具有延缓衰老以及提高免疫力的作用。但是该发明制备得到的细胞修复剂在使用过程中各成分之间并未能相互很好得溶解，人体吸收效果较差。
将玉米低聚肽粉与其他原料复配，可以提高玉米低聚肽粉的稳定性和生物活性，拓宽玉米低聚肽的应用范围。将玉米低聚肽做成内服和外用的产品鲜有报道。
发明内容
本发明提供一种复合玉米低聚肽胶囊及其制备方法，该复合玉米低聚肽胶囊营养价值高、稳定性好、溶解性强，易于被人体吸收，能够内服和外用。外用时能够有效改善肤质，增强皮肤性能，具有美白肌肤，延缓肌肤衰老，淡化斑痕的效果；内服时能够有效清除人体自由基，延缓衰老作用，同时还能够有助于抗高血压、解酒护肝、增强人体免疫力。
本发明的方案是通过这样实现的：一种复合玉米低聚肽胶囊，其各组成成分及其重量份数比为：玉米低聚肽粉30~40份、甜橙粉15~20份、木糖醇15~18份、茶多酚12~16份、茶氨酸13~15份、壳寡糖12~15份、维生素E3~6份、柑橘油12~16份、蔗糖酯10~12份、玉竹提取物8~12份、鱼腥草提取物6~8份、酢浆草提取物6~8份、茜草提取物6~8份、纯水适量。
一种制备复合玉米低聚肽胶囊的方法，包括以下制备步骤：
(1)玉竹提取物的制备：取玉竹洗净，烘干，粉碎后得到玉竹粉，将玉竹粉与体积分数70％的乙醇溶液按照料液比为1:10(w/v)混合均匀，保持温度在30~40℃，在搅拌条件下浸提4~5h，然后将温度升至50~60℃进行超声提取15~20min得到提取混合物，将提取混合物进行膜过滤得到混合液，再将混合液进行真空减压浓缩至原体积的10~15%，然后进行喷雾干燥得到玉竹提取物；
(2)鱼腥草提取物的制备：取鱼腥草洗净，烘干，粉碎后得到鱼腥草粉，将鱼腥草粉与体积分数70％的乙醇溶液按照料液比为1:10(w/v)混合均匀，保持温度在30~40℃，在搅拌条件下浸提4~5h，然后将温度升至50~60℃进行超声提取15~20min得到提取混合物，将提取混合物进行膜过滤得到混合液，再将混合液进行真空减压浓缩至原体积的10~15%，然后进行喷雾干燥得到鱼腥草提取物；
(3)酢浆草提取物的制备：酢浆草提取物的制备：取酢浆草洗净，烘干，粉碎后得到酢浆草粉，将酢浆草粉与体积分数70％的乙醇溶液按照料液比为1:10(w/v)混合均匀，保持温度在30~40℃，在搅拌条件下浸提4~5h，然后将温度升至50~60℃进行超声提取15~20min得到提取混合物，将提取混合物进行膜过滤得到混合液，再将混合液进行真空减压浓缩至原体积的10~15%，然后进行喷雾干燥得到酢浆草提取物；
(4)茜草提取物的制备：茜草提取物的制备：取茜草洗净，烘干，粉碎后得到茜草粉，将茜草粉与体积分数70％的乙醇溶液按照料液比为1:10(w/v)混合均匀，保持温度在30~40℃，在搅拌条件下浸提4~5h，然后将温度升至50~60℃进行超声提取15~20min得到提取混合物，将提取混合物进行膜过滤得到混合液，再将混合液进行真空减压浓缩至原体积的10~15%，然后进行喷雾干燥得到茜草提取物；
(5)乳液的制备：取玉米低聚肽粉30~40份、甜橙粉15~20份、木糖醇15~18份、茶多酚12~16份、茶氨酸13~15份、壳寡糖12~15份、玉竹提取物8~12份、鱼腥草提取物6~8份、酢浆草提取物6~8份、茜草提取物6~8份加入反应釜中，然后加入纯水50~60份，在转速为80~120r/min下搅拌混合均匀，然后加入维生素E3~6份、柑橘油12~16份、蔗糖酯10~12份，在10000~12000r/min转速下搅拌1min，然后利用高压微射流纳米均质机均质3min，得到乳液；
(6)复合玉米低聚肽胶囊的制备：将海藻酸钠和去离子水(质量比为1:49)在室温下搅拌溶解，得到质量分数为2%的海藻酸钠溶液；将氯化钙溶和去离子水(质量比为1:19)在室温下搅拌溶解，得到质量分数为2%的氯化钙溶液；往海藻酸钠溶液中添加甘油，使得海藻酸钠溶液与甘油质量比为10:3，升温至70℃，然后再加入氯化钙溶液搅拌混合反应1~2h，然后抽真空消去气泡，再进行过滤得到胶囊材料，将胶囊材料置于60℃胶桶中并与软胶囊制粒机相连，将乳液加入料槽中，调节胶盒及喷体温度38~42℃，乳液装量为0.5g/粒，调节胶皮厚度为1.0mm，滚磨转速为2.5r/min进行软胶囊的压制，压制后在25℃、相对湿度25%~30%条件下，干燥10~12h即得复合玉米低聚肽胶囊。
作为本发明的进一步改进，制备得到的复合玉米低聚肽胶囊内服或外用。
本发明实现的技术原理是：
本发明以玉米低聚肽粉为主要原材料与其他材料复配混合来制备。玉米低聚肽粉采用生物工程定向酶切技术提取的小分子肽，溶解性强，稳定性好，易于被人体吸收利用。将原料制备成微乳液，微乳液可以使油水相溶性强，从而增强原料中各组分之间的相溶性，也提高组分之间的稳定性，制备得到的微乳液分子小更能更快地渗入皮肤中被皮肤快速吸收，提高乳液的利用率。将微乳液制备成胶囊，可以避免光、热、水等对微乳液的影响，提高微乳液的贮存稳定性。
外用时，复合玉米低聚肽胶囊可以为肌肤补充营养，调节肌肤。玉米低聚肽粉可以阻断肌肉与神经之间的传导，使得肌肤皱纹放松，它还具有抗氧化性，能够清除或抑制自由基的产生达到阻止或延缓皮肤的衰老，在防晒、抗皱和美白方面也有一定的作用。甜橙粉是将橙汁与麦芽糊精进行复配使用，甜橙粉中含有丰富的维生素C、麦芽糊精，外用时能够对肌肤起到美白滋润的效果。木糖醇外用时具有甘油相同的保湿和改善皮肤粗糙的效果，且使用时不发粘，甜橙粉与玉米低聚肽粉、木糖醇相互作用，能够有效改善肌肤问题，使肌肤滋润有弹性、抗衰老。茶多酚和茜草抗辐射作用，能有效地阻止放射性物质侵入人体中，同时也具有较强的抗氧化作用，能够清除肌肤自由基的产生，延缓肌肤衰老。茶多酚具有一定的除臭抑菌效果，能够抑制产品中微生物的生长，延缓产品保质期。茶氨酸、玉竹和鱼腥草提取物能够对肌肤起到润滑作用，玉竹、鱼腥草还能够提高细胞活性，有活肤作用，且能够抑制黑色素的生成，达到肌肤美白、淡斑的效果。维生素E具有抗氧化作用，外用时能够具有祛斑、防皱效果，此外维生素E还能够帮助细胞更好地吸收外部护肤品的营养成分，使美容功效加倍。柑橘油具有美白补水保湿效果。酢浆草、茜草具有清热解毒效果，外用使能够消肿解毒，对脸上的痤疮有一定的消除作用，酢浆草和茜草还具有抑菌、杀菌效果，外用时能够清除皮肤表皮的细菌，与茶多酚复合还能够提高产品的保存期。通过原料各个成分的相互作用，本发明的复合玉米低聚肽胶囊外用时对肌肤能够起到美白、润湿、抗衰老、淡化斑痕等效果。
内服时，玉米低聚肽粉富含氢供体，可使具有高度氧化性的自由基还原，而终止自由基链式反应，起到清除或抑制自由基的目的。茶多酚结构中的羟基可提供活泼的氢从而使自由基灭活。玉竹总黄酮与维生素C有相似的体外抗氧化能力。酢浆草含有的黄酮类化合物具有抗氧化活性。茜草提取物也含有抗氧化物质。通过玉米低聚肽粉、茶多酚、玉竹提取物、酢浆草提取物、茜草提取物的相互作用，能够有效清除人体内自由基达到，提高人体的抗氧化作用，延缓人体衰老。玉米低聚肽粉中含有较高比例的Leu、Val、Ala等疏水性氨基酸和Pro、Glu等，特殊的组合使得玉米低聚肽能够抑制血管张素转换酶(ACE)作用，对降血压有一定的作用。茶氨酸在体内可以调节抗氧化酶活力、降低氧化应激水平，在一定程度上能够缓解和预防高血压。茶氨酸可以通过脑中枢神经传达物质的浓度来发挥降血压作用。通过玉米低聚肽粉、茶氨酸对酶的调节以及茶氨酸在神经调节能够有效降低高血压。茶氨酸能够在人体肝脏中分解成乙胺，从而调动T淋巴细胞产生干扰素，形成抵制感染的防线，增强人体免疫力。壳寡糖能够激活T淋巴细胞，从而使巨噬细胞激活因子的释放，进而激活巨噬细胞达到增强免疫力的作用。鱼腥草提取物中的鱼腥草素靠疏水作用于免疫细胞结合，对巨噬细胞的酶系发生激活作用，从而提高免疫力。在玉米低聚肽粉、壳寡糖、鱼腥草的相互作用下，能够有效增强人体免疫力。在抗肿瘤方面，茶多酚可以阻断亚硝酸盐等多种致癌物质在体内的合成，具有直接杀死癌细胞作用，壳寡糖可具有良好的抑制肿瘤细胞生长和抑制肿瘤细胞转移的作用。茜草中的多糖和蒽醌在一定程度上能够诱导肿瘤细胞的凋亡的直接作用和增强免疫力的间接作用具有抗癌抗肿瘤作用，玉竹提取物、酢浆草中的黄酮也具有抑制肿瘤作用，在茶多酚、壳寡糖、玉竹、茜草、酢浆草茜草的作用下，对肿瘤的预防和辅助治疗有一定的作用。
此外，内服时，玉米低聚肽可有效调节人体微环境，玉米低聚肽还能够激活胃黏膜ADH增强乙醇的代谢，促进血液中的酒精分解，增强肝功能、解酒、保肝护肝。甜橙粉和木糖醇可以调节制备得到的复合玉米低聚肽胶囊的适口性，木糖醇还能够提高肠内钙的吸收和体内钙的保留，促进人体对钙的吸收。维生素E在人体内能够有效抵抗自由基，抑制氧化脂质生成，祛除黄褐斑，还能够抑制酪氨酸酶的活性，从而减少黑色素生成，达到祛斑的效果。柑橘油具有多种不饱和脂肪酸能够为人体提供各种不饱和脂肪酸，有效促进人体健康。玉竹、鱼腥草、酢浆草内服时能够起到润燥、清热、生津、止咳等功效，有效调节人体健康。
本发明具备以下良好效果：
1.本发明得到的复合玉米低聚肽胶囊稳定性强易于保存，生物活性高，组份之间相溶性好，易于被人体吸收，利用率高，且适口性好，且原料来源安全，绿色环保。
2.本发明制备得到的复合玉米低聚肽胶囊可内服可外用，外用时能够有效缓解皮肤衰老，淡化斑痕美白的效果，能够改善皮肤；内服时解酒能力强，解酒见效快，还具有抗血压、护肝的作用，够能够有效调节人体内外环境，增强人体免疫力，促进人体健康，应用范围广。
具体实施方式
以下结合表1和实施例描述本发明一种复合玉米低聚肽胶囊及其制备方法，这些描述并不是对本发明内容作进一步的限定。
表1 实施例中的复合玉米低聚肽胶囊原料成分及其重量份数
实施例1
玉竹提取物的制备：取玉竹洗净，烘干，粉碎后得到玉竹粉，将玉竹粉与体积分数70％的乙醇溶液按照料液比为1:10(w/v)混合均匀，保持温度在32℃，在搅拌条件下浸提5h，然后将温度升至58℃进行超声提取15min得到提取混合物，将提取混合物进行膜过滤得到混合液，再将混合液进行真空减压浓缩至原体积的11%，然后进行喷雾干燥得到玉竹提取物；
鱼腥草提取物的制备：取鱼腥草洗净，烘干，粉碎后得到鱼腥草粉，将鱼腥草粉与体积分数70％的乙醇溶液按照料液比为1:10(w/v)混合均匀，保持温度在35℃，在搅拌条件下浸提4.5h，然后将温度升至60℃进行超声提取18min得到提取混合物，将提取混合物进行膜过滤得到混合液，再将混合液进行真空减压浓缩至原体积的12%，然后进行喷雾干燥得到鱼腥草提取物；
酢浆草提取物的制备：酢浆草提取物的制备：取酢浆草洗净，烘干，粉碎后得到酢浆草粉，将酢浆草粉与体积分数70％的乙醇溶液按照料液比为1:10(w/v)混合均匀，保持温度在30℃，在搅拌条件下浸提4.5h，然后将温度升至50℃进行超声提取15min得到提取混合物，将提取混合物进行膜过滤得到混合液，再将混合液进行真空减压浓缩至原体积的10%，然后进行喷雾干燥得到酢浆草提取物；
茜草提取物的制备：茜草提取物的制备：取茜草洗净，烘干，粉碎后得到茜草粉，将茜草粉与体积分数70％的乙醇溶液按照料液比为1:10(w/v)混合均匀，保持温度在30℃，在搅拌条件下浸提4h，然后将温度升至60℃进行超声提取20min得到提取混合物，将提取混合物进行膜过滤得到混合液，再将混合液进行真空减压浓缩至原体积的14%，然后进行喷雾干燥得到茜草提取物；
乳液的制备：取玉米低聚肽粉30份、甜橙粉18份、木糖醇16份、茶多酚14份、茶氨酸15份、壳寡糖13份、玉竹提取物10份、鱼腥草提取物7.5份、酢浆草提取物7份、茜草提取物8份加入反应釜中，然后加入纯水50~60份，在转速为90r/min下搅拌混合均匀，然后加入维生素E6份、柑橘油15份、蔗糖酯10份，在10000r/min转速下搅拌1min，然后利用高压微射流纳米均质机均质3min，得到乳液；
复合玉米低聚肽胶囊的制备：将海藻酸钠和去离子水(质量比为1:49)在室温下搅拌溶解，得到质量分数为2%的海藻酸钠溶液；将氯化钙溶和去离子水(质量比为1:19)在室温下搅拌溶解，得到质量分数为2%的氯化钙溶液；往海藻酸钠溶液中添加甘油，使得海藻酸钠溶液与甘油质量比为10:3，升温至70℃，然后再加入氯化钙溶液搅拌混合反应1h，然后抽真空消去气泡，再进行过滤得到胶囊材料，将胶囊材料置于60℃胶桶中并与软胶囊制粒机相连，将乳液加入料槽中，调节胶盒及喷体温度38℃，乳液装量为0.5g/粒，调节胶皮厚度为1.0mm，滚磨转速为2.5r/min进行软胶囊的压制，压制后在25℃、相对湿度25%条件下，干燥10h即得复合玉米低聚肽胶囊。
实施例2
玉竹提取物的制备：取玉竹洗净，烘干，粉碎后得到玉竹粉，将玉竹粉与体积分数70％的乙醇溶液按照料液比为1:10(w/v)混合均匀，保持温度在30℃，在搅拌条件下浸提4h，然后将温度升至55℃进行超声提取20min得到提取混合物，将提取混合物进行膜过滤得到混合液，再将混合液进行真空减压浓缩至原体积的10%，然后进行喷雾干燥得到玉竹提取物；
鱼腥草提取物的制备：取鱼腥草洗净，烘干，粉碎后得到鱼腥草粉，将鱼腥草粉与体积分数70％的乙醇溶液按照料液比为1:10(w/v)混合均匀，保持温度在30℃，在搅拌条件下浸提4h，然后将温度升至50℃进行超声提取20min得到提取混合物，将提取混合物进行膜过滤得到混合液，再将混合液进行真空减压浓缩至原体积的14%，然后进行喷雾干燥得到鱼腥草提取物；
酢浆草提取物的制备：酢浆草提取物的制备：取酢浆草洗净，烘干，粉碎后得到酢浆草粉，将酢浆草粉与体积分数70％的乙醇溶液按照料液比为1:10(w/v)混合均匀，保持温度在40℃，在搅拌条件下浸提4.8h，然后将温度升至60℃进行超声提取18min得到提取混合物，将提取混合物进行膜过滤得到混合液，再将混合液进行真空减压浓缩至原体积的13%，然后进行喷雾干燥得到酢浆草提取物；
茜草提取物的制备：茜草提取物的制备：取茜草洗净，烘干，粉碎后得到茜草粉，将茜草粉与体积分数70％的乙醇溶液按照料液比为1:10(w/v)混合均匀，保持温度在40℃，在搅拌条件下浸提4.8h，然后将温度升至50℃进行超声提取18min得到提取混合物，将提取混合物进行膜过滤得到混合液，再将混合液进行真空减压浓缩至原体积的13%，然后进行喷雾干燥得到茜草提取物；
乳液的制备：取玉米低聚肽粉33份、甜橙粉20份、木糖醇15份、茶多酚16份、茶氨酸13份、壳寡糖15份、玉竹提取物8份、鱼腥草提取物8份、酢浆草提取物6.5份、茜草提取物7份加入反应釜中，然后加入纯水50~60份，在转速为80r/min下搅拌混合均匀，然后加入维生素E3份、柑橘油16份、蔗糖酯11份，在12000r/min转速下搅拌1min，然后利用高压微射流纳米均质机均质3min，得到乳液；
复合玉米低聚肽胶囊的制备：将海藻酸钠和去离子水(质量比为1:49)在室温下搅拌溶解，得到质量分数为2%的海藻酸钠溶液；将氯化钙溶和去离子水(质量比为1:19)在室温下搅拌溶解，得到质量分数为2%的氯化钙溶液；往海藻酸钠溶液中添加甘油，使得海藻酸钠溶液与甘油质量比为10:3，升温至70℃，然后再加入氯化钙溶液搅拌混合反应2h，然后抽真空消去气泡，再进行过滤得到胶囊材料，将胶囊材料置于60℃胶桶中并与软胶囊制粒机相连，将乳液加入料槽中，调节胶盒及喷体温度42℃，乳液装量为0.5g/粒，调节胶皮厚度为1.0mm，滚磨转速为2.5r/min进行软胶囊的压制，压制后在25℃、相对湿度30%条件下，干燥11h即得复合玉米低聚肽胶囊。
实施例3
玉竹提取物的制备：取玉竹洗净，烘干，粉碎后得到玉竹粉，将玉竹粉与体积分数70％的乙醇溶液按照料液比为1:10(w/v)混合均匀，保持温度在40℃，在搅拌条件下浸提4.2h，然后将温度升至52℃进行超声提取16min得到提取混合物，将提取混合物进行膜过滤得到混合液，再将混合液进行真空减压浓缩至原体积的15%，然后进行喷雾干燥得到玉竹提取物；
鱼腥草提取物的制备：取鱼腥草洗净，烘干，粉碎后得到鱼腥草粉，将鱼腥草粉与体积分数70％的乙醇溶液按照料液比为1:10(w/v)混合均匀，保持温度在40℃，在搅拌条件下浸提5h，然后将温度升至58℃进行超声提取15min得到提取混合物，将提取混合物进行膜过滤得到混合液，再将混合液进行真空减压浓缩至原体积的13%，然后进行喷雾干燥得到鱼腥草提取物；
酢浆草提取物的制备：酢浆草提取物的制备：取酢浆草洗净，烘干，粉碎后得到酢浆草粉，将酢浆草粉与体积分数70％的乙醇溶液按照料液比为1:10(w/v)混合均匀，保持温度在38℃，在搅拌条件下浸提4.2h，然后将温度升至58℃进行超声提取20min得到提取混合物，将提取混合物进行膜过滤得到混合液，再将混合液进行真空减压浓缩至原体积的15%，然后进行喷雾干燥得到酢浆草提取物；
茜草提取物的制备：茜草提取物的制备：取茜草洗净，烘干，粉碎后得到茜草粉，将茜草粉与体积分数70％的乙醇溶液按照料液比为1:10(w/v)混合均匀，保持温度在38℃，在搅拌条件下浸提4.2h，然后将温度升至55℃进行超声提取15min得到提取混合物，将提取混合物进行膜过滤得到混合液，再将混合液进行真空减压浓缩至原体积的10%，然后进行喷雾干燥得到茜草提取物；
乳液的制备：取玉米低聚肽粉35份、甜橙粉16份、木糖醇17份、茶多酚15份、茶氨酸13份、壳寡糖12份、玉竹提取物9份、鱼腥草提取物6份、酢浆草提取物7份、茜草提取物7.5份加入反应釜中，然后加入纯水50~60份，在转速为100r/min下搅拌混合均匀，然后加入维生素E5份、柑橘油14份、蔗糖酯10.5份，在11000r/min转速下搅拌1min，然后利用高压微射流纳米均质机均质3min，得到乳液；
复合玉米低聚肽胶囊的制备：将海藻酸钠和去离子水(质量比为1:49)在室温下搅拌溶解，得到质量分数为2%的海藻酸钠溶液；将氯化钙溶和去离子水(质量比为1:19)在室温下搅拌溶解，得到质量分数为2%的氯化钙溶液；往海藻酸钠溶液中添加甘油，使得海藻酸钠溶液与甘油质量比为10:3，升温至70℃，然后再加入氯化钙溶液搅拌混合反应1.5h，然后抽真空消去气泡，再进行过滤得到胶囊材料，将胶囊材料置于60℃胶桶中并与软胶囊制粒机相连，将乳液加入料槽中，调节胶盒及喷体温度40℃，乳液装量为0.5g/粒，调节胶皮厚度为1.0mm，滚磨转速为2.5r/min进行软胶囊的压制，压制后在25℃、相对湿度28%条件下，干燥10.5h即得复合玉米低聚肽胶囊。
实施例4
玉竹提取物的制备：取玉竹洗净，烘干，粉碎后得到玉竹粉，将玉竹粉与体积分数70％的乙醇溶液按照料液比为1:10(w/v)混合均匀，保持温度在35℃，在搅拌条件下浸提4.8h，然后将温度升至50℃进行超声提取18min得到提取混合物，将提取混合物进行膜过滤得到混合液，再将混合液进行真空减压浓缩至原体积的12%，然后进行喷雾干燥得到玉竹提取物；
鱼腥草提取物的制备：取鱼腥草洗净，烘干，粉碎后得到鱼腥草粉，将鱼腥草粉与体积分数70％的乙醇溶液按照料液比为1:10(w/v)混合均匀，保持温度在38℃，在搅拌条件下浸提4.2h，然后将温度升至52℃进行超声提取16min得到提取混合物，将提取混合物进行膜过滤得到混合液，再将混合液进行真空减压浓缩至原体积的10%，然后进行喷雾干燥得到鱼腥草提取物；
酢浆草提取物的制备：酢浆草提取物的制备：取酢浆草洗净，烘干，粉碎后得到酢浆草粉，将酢浆草粉与体积分数70％的乙醇溶液按照料液比为1:10(w/v)混合均匀，保持温度在35℃，在搅拌条件下浸提4h，然后将温度升至55℃进行超声提取16min得到提取混合物，将提取混合物进行膜过滤得到混合液，再将混合液进行真空减压浓缩至原体积的14%，然后进行喷雾干燥得到酢浆草提取物；
茜草提取物的制备：茜草提取物的制备：取茜草洗净，烘干，粉碎后得到茜草粉，将茜草粉与体积分数70％的乙醇溶液按照料液比为1:10(w/v)混合均匀，保持温度在35℃，在搅拌条件下浸提5h，然后将温度升至52℃进行超声提取17min得到提取混合物，将提取混合物进行膜过滤得到混合液，再将混合液进行真空减压浓缩至原体积的15%，然后进行喷雾干燥得到茜草提取物；
乳液的制备：取玉米低聚肽粉37份、甜橙粉15份、木糖醇18份、茶多酚12份、茶氨酸13.5份、壳寡糖14份、玉竹提取物11份、鱼腥草提取物6.5份、酢浆草提取物7.5份、茜草提取物6份加入反应釜中，然后加入纯水50~60份，在转速为110r/min下搅拌混合均匀，然后加入维生素E4份、柑橘油12份、蔗糖酯12份，在10500r/min转速下搅拌1min，然后利用高压微射流纳米均质机均质3min，得到乳液；
复合玉米低聚肽胶囊的制备：将海藻酸钠和去离子水(质量比为1:49)在室温下搅拌溶解，得到质量分数为2%的海藻酸钠溶液；将氯化钙溶和去离子水(质量比为1:19)在室温下搅拌溶解，得到质量分数为2%的氯化钙溶液；往海藻酸钠溶液中添加甘油，使得海藻酸钠溶液与甘油质量比为10:3，升温至70℃，然后再加入氯化钙溶液搅拌混合反应2h，然后抽真空消去气泡，再进行过滤得到胶囊材料，将胶囊材料置于60℃胶桶中并与软胶囊制粒机相连，将乳液加入料槽中，调节胶盒及喷体温度41℃，乳液装量为0.5g/粒，调节胶皮厚度为1.0mm，滚磨转速为2.5r/min进行软胶囊的压制，压制后在25℃、相对湿度27%条件下，干燥11.5h即得复合玉米低聚肽胶囊。
实施例5
玉竹提取物的制备：取玉竹洗净，烘干，粉碎后得到玉竹粉，将玉竹粉与体积分数70％的乙醇溶液按照料液比为1:10(w/v)混合均匀，保持温度在38℃，在搅拌条件下浸提4.5h，然后将温度升至60℃进行超声提取19min得到提取混合物，将提取混合物进行膜过滤得到混合液，再将混合液进行真空减压浓缩至原体积的14%，然后进行喷雾干燥得到玉竹提取物；
鱼腥草提取物的制备：取鱼腥草洗净，烘干，粉碎后得到鱼腥草粉，将鱼腥草粉与体积分数70％的乙醇溶液按照料液比为1:10(w/v)混合均匀，保持温度在32℃，在搅拌条件下浸提4.8h，然后将温度升至55℃进行超声提取17min得到提取混合物，将提取混合物进行膜过滤得到混合液，再将混合液进行真空减压浓缩至原体积的15%，然后进行喷雾干燥得到鱼腥草提取物；
酢浆草提取物的制备：酢浆草提取物的制备：取酢浆草洗净，烘干，粉碎后得到酢浆草粉，将酢浆草粉与体积分数70％的乙醇溶液按照料液比为1:10(w/v)混合均匀，保持温度在32℃，在搅拌条件下浸提5h，然后将温度升至52℃进行超声提取17min得到提取混合物，将提取混合物进行膜过滤得到混合液，再将混合液进行真空减压浓缩至原体积的12%，然后进行喷雾干燥得到酢浆草提取物；
茜草提取物的制备：茜草提取物的制备：取茜草洗净，烘干，粉碎后得到茜草粉，将茜草粉与体积分数70％的乙醇溶液按照料液比为1:10(w/v)混合均匀，保持温度在32℃，在搅拌条件下浸提4.2h，然后将温度升至58℃进行超声提取16min得到提取混合物，将提取混合物进行膜过滤得到混合液，再将混合液进行真空减压浓缩至原体积的11%，然后进行喷雾干燥得到茜草提取物；
乳液的制备：取玉米低聚肽粉40份、甜橙粉17份、木糖醇15份、茶多酚13份、茶氨酸14.5份、壳寡糖13份、玉竹提取物12份、鱼腥草提取物7份、酢浆草提取物6份、茜草提取物6.5份加入反应釜中，然后加入纯水50~60份，在转速为120r/min下搅拌混合均匀，然后加入维生素E4份、柑橘油13份、蔗糖酯11.5份，在11500r/min转速下搅拌1min，然后利用高压微射流纳米均质机均质3min，得到乳液；
复合玉米低聚肽胶囊的制备：将海藻酸钠和去离子水(质量比为1:49)在室温下搅拌溶解，得到质量分数为2%的海藻酸钠溶液；将氯化钙溶和去离子水(质量比为1:19)在室温下搅拌溶解，得到质量分数为2%的氯化钙溶液；往海藻酸钠溶液中添加甘油，使得海藻酸钠溶液与甘油质量比为10:3，升温至70℃，然后再加入氯化钙溶液搅拌混合反应1h，然后抽真空消去气泡，再进行过滤得到胶囊材料，将胶囊材料置于60℃胶桶中并与软胶囊制粒机相连，将乳液加入料槽中，调节胶盒及喷体温度39℃，乳液装量为0.5g/粒，调节胶皮厚度为1.0mm，滚磨转速为2.5r/min进行软胶囊的压制，压制后在25℃、相对湿度26%条件下，干燥12h即得复合玉米低聚肽胶囊。
为了验证本发明制备得到的复合玉米低聚肽胶囊的各项性能，将本发明得到的复合玉米低聚肽胶囊用于试验。
1.外用试验。
选取100名年龄在25-65实验者，男女各半，平均分成5组每组10名男性，10名女性，分别使用由实施例1~5制得的复合玉米低聚肽胶囊将胶囊剥开，将乳液均匀涂抹到脸上，在每天洁面后使用，每天一次，连续使用30天，记录每位试验者的使用效果，综合评价打分，取平均分，最高分为5分，表示使用效果显著，4分表示使用效果良好，3分使用效果一般，3分以下为使用效果差。实验结果如下表所示。
表2 复合玉米低聚肽胶囊外用实验效果
具体试验案例如下：
(1)黄某某，女，45岁，使用本产品前皮肤皮肤暗黄松弛，眼角和嘴角有皱纹使用本产品30天后，皮肤滋润柔嫩，脸上皱纹深度变浅，皮肤干净变白。
(2)杨某某，男，30岁，使用本产品前皮肤干燥，粗糙，暗黄，使用本产品30天后，皮肤滋润光滑、洁净。
(3)韦某某，女，28岁，使用本产品前肤色粗糙、油腻，脸上有晒斑，黑头多使用本产品30天后，肤色光滑有弹性，洁净，不油腻，脸上斑痕淡化。
2.内服试验。
(1)解酒试验
试验内容：选取120名年龄为25~35岁的男性，平均年龄为29岁。平均分成6组，每组20人。第1~5组分别试验实施例1~5的产品，第6组设置为对照组，共进行2次试验，参与人员测试一个产品后隔4天再进行下次试验。具体步骤如下：参与人员在午餐正常进餐，实验组人员饮酒前10min吞下实施例制备得到的复合玉米低聚肽胶囊3粒，对照组人员则不服用复合玉米低聚肽胶囊，每人40分钟内喝2两56°红星二锅头。喝酒完毕后采用呼吸式酒精检测仪分别检测4h内饮酒人员不同时间呼气中的酒精含量，结果取平均值。试验结果如下表3所示。
表3 解酒试验结果
(2)护肝试验
取同日龄大鼠60只，雌雄各半，体重220±20g，适应性饲养20天后，将大鼠随机分为6组。第1~5组其每周2次用50％酒精灌胃进行造模，每次50mL，持续6周，其余时间用10％酒精进行灌胃，每天1次；其中，从第3周开始，每隔1天用1粒含实施例1~5所得的复合玉米低聚肽胶囊和10％酒精进行灌胃；第6组为对照组，其每周2次用50％酒精灌胃进行造模，每次50mL，持续6周，其余时间用蒸馏水进行灌胃，每天1次。处理结束后分别采用甘油三酯(TG)试剂盒、血清丙氨酸氨基转移酶(ALT)试剂盒、血清冬氨酸氨基转移酶(AST)试剂盒和丙二醛(MDA)试剂盒进行各项指标检测，其检测结果见表4。
表4 护肝测试结果
(3)调节血压试验
取自发性高血压大鼠60只，雌性，6~8周龄，体重180~200g，动物在实验室适应1周后，根据所测基础血压及体重的大小，按随机区组设计分为6组，第1~5组分别食用本发明实施例制备得到的复合玉米低聚肽胶囊，第6组为对照组，自由进食饮水，实验期共30天。分别测定实验前和试验30天后大鼠的血压。血压的测定方法为：用尾袖法以BP-98A血压记录仪从大鼠尾动脉记录血压，结果取平均值。
表5 复合玉米低聚肽胶囊对大鼠血压的影响
本发明上述实施例方案仅是对本发明的说明而不能限制本发明，权利要求中指出了本发明产品组成成分、成分比例、制备方法参数的范围，而上述的说明并未指出本发明参数的范围，因此，在与本发明的权利要求书相当的含义和范围内的任何改变，都应当认为是包括在权利要求书的范围内。
本发明是经过多位低聚肽粉加工人员长期工作经验积累，并通过创造性劳动创作而出，本发明制备得到的产品各项性能好，可内服可外用，作用效果好，有利于人体健康。
Claims (3)
1.一种复合玉米低聚肽胶囊，其特征是，所述的复合玉米低聚肽胶囊各组成成分及其重量份数比为：玉米低聚肽粉30~40份、甜橙粉15~20份、木糖醇15~18份、茶多酚12~16份、茶氨酸13~15份、壳寡糖12~15份、维生素E3~6份、柑橘油12~16份、蔗糖酯10~12份、玉竹提取物8~12份、鱼腥草提取物6~8份、酢浆草提取物6~8份、茜草提取物6~8份、纯水适量。
2.一种制备如权利要求1所述的复合玉米低聚肽胶囊的方法，其特征是，包括以下制备步骤：
步骤1)玉竹提取物的制备：取玉竹洗净，烘干，粉碎后得到玉竹粉，将玉竹粉与体积分数70％的乙醇溶液按照料液比为1:10(w/v)混合均匀，保持温度在30~40℃，在搅拌条件下浸提4~5h，然后将温度升至50~60℃进行超声提取15~20min得到提取混合物，将提取混合物进行膜过滤得到混合液，再将混合液进行真空减压浓缩至原体积的10~15%，然后进行喷雾干燥得到玉竹提取物；
步骤2)鱼腥草提取物的制备：取鱼腥草洗净，烘干，粉碎后得到鱼腥草粉，将鱼腥草粉与体积分数70％的乙醇溶液按照料液比为1:10(w/v)混合均匀，保持温度在30~40℃，在搅拌条件下浸提4~5h，然后将温度升至50~60℃进行超声提取15~20min得到提取混合物，将提取混合物进行膜过滤得到混合液，再将混合液进行真空减压浓缩至原体积的10~15%，然后进行喷雾干燥得到鱼腥草提取物；
步骤3)酢浆草提取物的制备：酢浆草提取物的制备：取酢浆草洗净，烘干，粉碎后得到酢浆草粉，将酢浆草粉与体积分数70％的乙醇溶液按照料液比为1:10(w/v)混合均匀，保持温度在30~40℃，在搅拌条件下浸提4~5h，然后将温度升至50~60℃进行超声提取15~20min得到提取混合物，将提取混合物进行膜过滤得到混合液，再将混合液进行真空减压浓缩至原体积的10~15%，然后进行喷雾干燥得到酢浆草提取物；
步骤4)茜草提取物的制备：茜草提取物的制备：取茜草洗净，烘干，粉碎后得到茜草粉，将茜草粉与体积分数70％的乙醇溶液按照料液比为1:10(w/v)混合均匀，保持温度在30~40℃，在搅拌条件下浸提4~5h，然后将温度升至50~60℃进行超声提取15~20min得到提取混合物，将提取混合物进行膜过滤得到混合液，再将混合液进行真空减压浓缩至原体积的10~15%，然后进行喷雾干燥得到茜草提取物；
步骤5)乳液的制备：取玉米低聚肽粉30~40份、甜橙粉15~20份、木糖醇15~18份、茶多酚12~16份、茶氨酸13~15份、壳寡糖12~15份、玉竹提取物8~12份、鱼腥草提取物6~8份、酢浆草提取物6~8份、茜草提取物6~8份加入反应釜中，然后加入纯水50~60份，在转速为80~120r/min下搅拌混合均匀，然后加入维生素E3~6份、柑橘油12~16份、蔗糖酯10~12份，在10000~12000r/min转速下搅拌1min，然后利用高压微射流纳米均质机均质3min，得到乳液；
步骤6)复合玉米低聚肽胶囊的制备：将海藻酸钠和去离子水(质量比为1:49)在室温下搅拌溶解，得到质量分数为2%的海藻酸钠溶液；将氯化钙溶和去离子水(质量比为1:19)在室温下搅拌溶解，得到质量分数为2%的氯化钙溶液；往海藻酸钠溶液中添加甘油，使得海藻酸钠溶液与甘油质量比为10:3，升温至70℃，然后再加入氯化钙溶液搅拌混合反应1~2h，然后抽真空消去气泡，再进行过滤得到胶囊材料，将胶囊材料置于60℃胶桶中并与软胶囊制粒机相连，将乳液加入料槽中，调节胶盒及喷体温度38~42℃，乳液装量为0.5g/粒，调节胶皮厚度为1.0mm，滚磨转速为2.5r/min进行软胶囊的压制，压制后在25℃、相对湿度25%~30%条件下，干燥10~12h即得复合玉米低聚肽胶囊。
3.根据权利要求2所述的一种制备复合玉米低聚肽胶囊的方法，其特征是：制备得到的复合玉米低聚肽胶囊内服或者外用。
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| CN110151645A (zh) * | 2019-05-09 | 2019-08-23 | 广州颜尚化妆品有限公司 | 一种植物源皮肤修护霜及其制备方法 |
| CN116508991A (zh) * | 2023-05-17 | 2023-08-01 | 哈尔滨三联药业股份有限公司 | 解酒组合物及其制备方法和应用 |
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| CN110151645A (zh) * | 2019-05-09 | 2019-08-23 | 广州颜尚化妆品有限公司 | 一种植物源皮肤修护霜及其制备方法 |
| CN116508991A (zh) * | 2023-05-17 | 2023-08-01 | 哈尔滨三联药业股份有限公司 | 解酒组合物及其制备方法和应用 |
| CN116508991B (zh) * | 2023-05-17 | 2023-11-24 | 哈尔滨三联药业股份有限公司 | 解酒组合物及其制备方法和应用 |
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