CN108404015B

CN108404015B - Stable slow-release sachet with effects of removing dirt and refreshing mind and preparation method thereof

Info

Publication number: CN108404015B
Application number: CN201810453670.7A
Authority: CN
Inventors: 陈飞芳; 潘嬿
Original assignee: Hangzhou Huqingyutang Natural Food Co ltd
Current assignee: Hangzhou Huqingyutang Natural Food Co ltd
Priority date: 2018-05-14
Filing date: 2018-05-14
Publication date: 2021-05-14
Anticipated expiration: 2038-05-14
Also published as: CN108404015A

Abstract

The invention discloses a slow-release sachet with the functions of removing dirt and refreshing mind and a preparation method thereof, and the slow-release sachet comprises the following components: the preparation method comprises the steps of selecting, detecting, drying and crushing mint, angelica dahurica, rhizoma nardostachyos, clove, sandalwood, elsholtzia, folium artemisiae argyi and cinnamon, powdering the mint, the angelica dahurica, the rhizoma nardostachyos, the clove, the rhizoma kaempferiae, the sandalwood, the elsholtzia, the folium artemisiae argyi and the cinnamon according to corresponding proportion, controlling fine powder to be 60-80 meshes, controlling particle diameter to be 0.18-0.25mm, preparing pills, checking, packaging and the like.

Description

Stable slow-release sachet with effects of removing dirt and refreshing mind and preparation method thereof

Technical Field

The invention relates to a slow-release sachet with the functions of removing dirt and refreshing mind and a preparation method thereof. In particular to a formula compatibility, a production process and a quality control of a slow-release (pill) sachet containing Chinese medicinal materials such as clove, mint, angelica dahurica, nardostachys root, rhizoma kaempferiae, sandalwood, elsholtzia, folium artemisiae argyi, cinnamon and the like.

Background

The perfume bag is an ornament for traditional perfume holding in China, and is particularly suitable for people wearing the perfume bag during the morning hours, so that the perfume bag is helpful for preventing insects, deodorizing, inducing resuscitation and restoring consciousness. In particular, in recent years, various sub-health states are often induced due to air pollution, a short pace of life, and an increase in work pressure. Resistance is reduced due to sub-health, so that people are easily attacked by various viruses, and the people become susceptible people during frequent influenza. Therefore, the application of the sachet is a stock article which is used in the morning and afternoon in short time and is prolonged to spring, fragrant and autumn, and the sachet can be carried about and can also be hung in a relatively closed environment such as indoors and in a car. The common sachet in the current market exists: random compatibility, bagging of coarse powder, short-term distribution, over-strong new bag, and non-lasting for a long time. Therefore, the invention combines the basic theory of traditional Chinese medicine, the nature and taste effects of traditional Chinese medicine, the technology of preparing pills of traditional Chinese medicine and the like, optimizes the formula compatibility of the sachet, improves the original process and ensures that the effective components are uniformly dispersed and have long effect. Namely, the invention provides a stable slow-release sachet with the functions of avoiding dirt and refreshing mind.

Disclosure of Invention

The purpose of the invention is: further, the stable slow release efficiency of the sachet is ensured by optimizing the formula of the sachet and improving the pelleting process, the slow release performance is verified, and the sachet produced by the new process can meet the effective concentration of 9 months.

The specific technical scheme of the invention is as follows:

the invention discloses a stable slow-release sachet with the functions of avoiding dirty and refreshing, which comprises the following components: mint, angelica dahurica, nardostachys chinensis bunge, clove, rhizoma kaempferiae, sandalwood, elsholtzia, folium artemisiae argyi and cinnamon.

As a further improvement, the sachet comprises the following components in parts by weight:

2-8 parts of mint

2-8 parts of angelica dahurica

1-7 parts of nardostachys chinensis bunge

1-5 parts of clove

1-8 parts of rhizoma kaempferiae

3-8 parts of sandalwood

1-6 parts of Chinese mosla herb

1-8 parts of folium artemisiae argyi

1-5 parts of cinnamon.

The range of the components in the first scheme is wide, samples prepared in the range are fresh in fragrance as well, the effect of avoiding filth and refreshing mind is achieved, but the partial materials are too abrupt in weight and do not form atmosphere when the amount is small, for example, 2-8 parts of radix angelicae are taken for testing, and the whole sachet is not fragrant enough; and 8 parts of the test is too strong, and the formula according to the scheme has corresponding difference in the acceptance of different crowds in practical application like the use amount and the slightly larger span of other flavors, but the technical effect of the invention can also be realized.

2-6 parts of mint

2-6 parts of angelica dahurica

1-5 parts of nard

1-4 parts of clove

1-6 parts of rhizoma kaempferiae

3-7 parts of sandalwood

1-5 parts of Chinese mosla herb

2-6 parts of folium artemisiae argyi

1-3 parts of cinnamon.

Based on the first scheme, it is further preferable that too much or too little formula is excluded according to the ingredient test result.

4 portions of mint

4 portions of angelica dahurica

3 portions of nard

2 portions of clove

Kaempferia galanga 2 parts

4 portions of sandalwood

Herba Moslae 2 parts

2 parts of folium artemisiae argyi

1 part of cinnamon.

And on the basis of the second scheme, performing blind smelling, namely, on the basis of not informing the formula, enabling the common people to perform smelling and scoring, wherein the acceptance degree is highest, the score is highest, and finally the optimized technical scheme is obtained.

The invention also discloses a method for preparing the stable slow-release sachet with the functions of removing dirt and refreshing mind, the preparation method comprises the steps of material selection and detection, drying and crushing, pelleting, inspection and packaging, and the specific preparation steps are as follows:

1) selecting and detecting: detecting the new medicinal materials in the same year by adopting genuine detection, controlling the volatile oil of the raw materials by taking the effective components as the aromatic volatile oil, purchasing at fixed points, cleaning the fresh-goods production place, and drying at low temperature to obtain dry products for later use;

2) drying and crushing: pulverizing herba Menthae, radix Angelicae Dahuricae, rhizoma Nardostachyos, flos Caryophylli, rhizoma Kaempferiae, lignum Santali albi, herba Moslae, folium Artemisiae Argyi and cortex Cinnamomi at a ratio of 60-80 mesh, and particle diameter of 0.18-0.25 mm;

3) pelleting: collecting fine powder 1/20, making mold with purified water, sieving to remove fine powder, and making into pill;

4) and (4) checking: after production, sampling detection is carried out, and the technical requirements are as follows: appearance, diameter, water content, disintegration time limit, volatile oil content and hygiene data;

5) and packaging: and packaging the qualified products, namely packaging the qualified products in heat-sealed filter paper bags containing the material pills, wrapping the folded products with clean elastic wadding, filling the folded products into a sachet, and boxing and warehousing the sachet.

As a further improvement, in step 1) of the present invention, the raw material volatile oil: more than 0.40 percent of volatile oil in mint, more than 0.080 percent of imperatorin in angelica dahurica, more than 2.0 percent of volatile oil in nardostachys root, more than 4.5 percent of volatile oil in kaempferia galanga, more than 3.0 percent of volatile oil in sandalwood, more than 0.16 percent of thymol in elsholtzia and carvacrol in total, more than 0.050 percent of eucalyptol in folium artemisiae argyi, more than 11.0 percent of eugenol in clove and more than 1.5 percent of cinnamaldehyde in cinnamon; the low temperature of the low-temperature drying is less than or equal to 60 ℃.

As a further improvement, in step 2) of the present invention, the powdering sequence is: pulverizing radix Angelicae Dahuricae and lignum Santali albi with heavy weight, adding herba Menthae and folium Artemisiae Argyi, soaking, and mixing with herba Moslae, rhizoma Kaempferiae, rhizoma Nardostachyos, flos Caryophylli and cortex Cinnamomi, pulverizing, and homogenizing.

As a further improvement, the specific preparation steps of the step 3) are as follows: taking 1/20 fine powder, using purified water to take a mould, screening out the fine powder, carrying out pelleting, wherein the air blast volume of a pelleting machine is 20Hz, the temperature is 30-45 ℃, the rotating speed is 20-30 r/min, the feeding powder is 1/3-1/2 of the weight of the mould each time, the purified water is in a fine mist shape, the atomizing pressure is 0.8-1.0Bar, the liquid spraying speed is 5-8ml/min, and the diameter of the pellets is 5-6 mm; keeping the temperature at 40-60 ℃, drying and rounding at the rotating speed of 30-45 r/min, and making pills in a hundred thousand grade purification area.

As a further improvement, the prepared ball of the invention comprises the following components: the appearance is brown round granule with diameter of 3-12mm, water content of less than or equal to 10.0%, disintegration time of 10-60 min, and volatile oil content of more than or equal to 2.0%.

As a further improvement, the prepared ball of the invention comprises the following components: diameter of 5-6mm, water content of 5.2%, disintegration time of 18 min, and volatile oil content of 2.7%.

The invention has the following effects and beneficial effects:

a slow-release sachet with the functions of avoiding dirt and refreshing:

monarch:

mint: dispelling wind and heat, clearing head and eyes, relieving sore throat, promoting eruption, dispersing stagnated liver qi, and promoting qi circulation, and contains volatile oil 0.40% or more

Minister:

radix angelicae: relieving exterior syndrome, dispelling cold, dispelling pathogenic wind, relieving pain, dredging nasal orifice, eliminating dampness, stopping leukorrhagia, relieving swelling, and expelling pus. Contains imperatorin more than 0.080%

And (3) rhizoma nardostachyos: regulating qi-flowing, relieving pain, resolving stagnation, activating spleen, removing dampness, relieving swelling, relieving toothache, and relieving swelling and pain of tinea pedis. Contains volatile oil more than 2.0%

The following are assisted and guided:

kaempferia galanga: promoting qi circulation, warming middle energizer, promoting digestion, and relieving pain, and contains volatile oil 4.5% or more

Sandalwood: move qi and warm middle energizer, stimulate appetite and alleviate pain. Contains volatile oil above 3.0%

Herba Moslae: inducing sweat, relieving exterior syndrome, eliminating dampness, regulating stomach, and containing thymol and carvacrol more than 0.16%,

Folium artemisiae argyi: warming channels to stop bleeding, dispelling cold to relieve pain, eliminating dampness and relieving itching for external use, contains eucalyptol more than 0.050%

Clove: containing eugenol over 11.0%, and has effects in warming middle-jiao, lowering adverse qi, invigorating kidney, and supporting yang

Cinnamon: tonifying fire and supporting yang, guiding fire to the origin, dispelling cold and relieving pain, and warming and dredging channels and collaterals contains more than 1.5% of cinnamaldehyde

The formula is compatible and combined according to the traditional Chinese medicine theory, the dirt-removing and refreshing effects of the sachet are guaranteed, the slow-release pill is prepared, 9 components are mutually contradictory in medicine property, the side effects of each other are relieved, the effects of each component are promoted to be enhanced, the treatment effect is improved, the application duration of the sachet is prolonged, and the sachet is suitable for three seasons of spring, summer and autumn.

Drawings

FIG. 1 is a schematic view of a volatile oil measuring apparatus;

in the figure, A is a 1000ml (or 500ml, 2000ml) hard round-bottom flask, B is a volatile oil determinator B, and C is a reflux condenser tube.

Detailed Description

The invention relates to a stable slow-release sachet with the functions of keeping dirty and refreshing mind, which comprises the following preferred raw materials: clove, mint, angelica dahurica, nardostachys root, rhizoma kaempferiae, sandalwood, elsholtzia, folium artemisiae argyi, cinnamon and the like.

The preparation method of the stable slow-release sachet with the functions of removing dirt and inducing resuscitation comprises the steps of material selection and detection, drying and crushing, pelleting and packaging, and the specific preparation steps are as follows:

1) selecting and detecting: detecting with genuine new medicinal materials in the same year, controlling volatile oil of raw materials based on aromatic volatile oil, purchasing at fixed point, cleaning fresh goods production place, and drying at low temperature to obtain dry product.

2) Crushing: pulverizing the raw materials at a certain ratio, adding herba Menthae and folium Artemisiae Argyi into the powder, adding the intermediate materials (such as herba Moslae, rhizoma Kaempferiae, rhizoma Nardostachyos, flos Caryophylli and cortex Cinnamomi), homogenizing, and controlling the fineness of the fine powder to 60-80 mesh (particle diameter of 0.18-0.25 mm).

3) Pelleting: taking fine powder 1/20, and taking a mold by using purified water, wherein the particle size of the mold is as follows: 1mm, sieving to remove fine powder, and performing pill making, wherein the air blowing amount of a pill making machine is 20Hz, the temperature is 30-45 ℃, and the rotating speed is 20-30 r/min: the feeding powder is 1/3-1/2 of the weight of the mold each time, the purified water is in a fine mist shape, the atomization pressure is 1.0Bar, and the liquid spraying speed is 5-8 ml/min; processing the balls to the diameter of 5-6 mm; keeping the temperature at 40-60 deg.C, and drying at 30-45 rpm.

4) And (4) checking: and (5) sampling and detecting after production is finished. The technical requirements are as follows: appearance, diameter, water content, disintegration time, volatile oil content, and hygiene data. And packaging after all the items are qualified, and filling the packaged products into heat-sealed filter paper bags in an automatic packaging machine at the ratio of 6-15 g/bag.

5) And folding the heat-sealed filter paper bag containing the material pills, wrapping the folded heat-sealed filter paper bag with clean elastic wadding, filling the folded heat-sealed filter paper bag into a sachet, boxing and warehousing.

The detection result of the finished product of the slow-release sachet pill needs to be in the following data range:

the technical scheme of the invention is further explained by combining the specific embodiment as follows:

example 1

The invention relates to a slow-release sachet with the functions of removing dirt and refreshing mind, which comprises the following raw materials:

4 portions of mint

4 portions of angelica dahurica

3 portions of nard

2 portions of clove

Kaempferia galanga 2 parts

4 portions of sandalwood

Herba Moslae 2 parts

2 parts of folium artemisiae argyi

1 part of cinnamon

1) Selecting and detecting: detecting by adopting genuine new-year medicinal materials, controlling the raw material volatile oil (the raw material components comprise more than 0.40 percent of mint containing volatile oil, more than 0.080 percent of angelica dahurica containing imperatorin, more than 2.0 percent of nardostachys root containing volatile oil, more than 4.5 percent of kaempferia galanga containing volatile oil, more than 3.0 percent of sandalwood containing volatile oil, more than 0.16 percent of elsholtzia containing thymol and mustachinol, more than 0.050 percent of folium artemisiae argyi containing eucalyptol, more than 11.0 percent of clove containing eugenol and more than 1.5 percent of cinnamon containing cinnamaldehyde) and purchasing at fixed points by taking the effective components as the aromatic volatile oil to ensure the stable quality of the raw materials; in addition, the fresh and good production places of the raw materials are cleaned and then dried into dry products at low temperature (less than or equal to 60 ℃) so as to ensure the cleanliness and the dryness and prevent the loss of effective components of the raw materials.

2) Crushing: pulverizing the raw materials at a certain ratio, adding soaking materials (herba Menthae and folium Artemisiae Argyi) and mixing with middle-grade materials (herba Moslae, rhizoma Kaempferiae, rhizoma Nardostachyos, flos Caryophylli and cortex Cinnamomi), homogenizing, and controlling the fineness of fine powder to 60 mesh (particle diameter of 0.18 mm).

3) Pelleting: taking fine powder 1/20, and taking a mold by using purified water, wherein the particle size of the mold is as follows: 1mm, sieving to remove fine powder, and performing pill making, wherein the air flow of a pill making machine is 20Hz, the temperature is 30-45 ℃, and the rotating speed is 30 r/min: the feeding powder is 1/3-1/2 of the weight of the mold each time, the purified water is in a fine mist shape, the atomization pressure is 1.0Bar, and the liquid spraying speed is 8 ml/min; processing the balls to the diameter of 5 mm; keeping the temperature at 50 ℃ and rotating speed at 30 r/min, drying and rounding. All pelleting environments are required to be carried out in a hundred thousand grade purification area so as to ensure the sanitation and cleanness of the sachet pills.

4) And (4) checking: and (5) sampling and detecting after production is finished. The technical requirements are as follows: appearance, diameter, water content, disintegration time limit, net content, volatile oil content, and hygiene data. And packaging the qualified products in bags, and putting the products into heat-sealed filter paper bags in an automatic packaging machine at a ratio of 12 g/bag. The packaging environment of the sachet pills is required to be carried out in a hundred thousand grade purification area.

5) And (3) thermally sealing the paper bag containing the pills with the filter paper, wrapping the paper bag with clean elastic wadding after folding, filling the paper bag into a sachet, and boxing and warehousing.

The detection result of the sustained-release sachet pill prepared in this example is as follows:

example 2

mint 2 parts

2 portions of angelica dahurica

1 part of nard

Clove 5 parts

Kaempferia galanga 8 parts

3 portions of sandalwood

Herba Moslae 1 part

6 parts of folium artemisiae argyi

4 portions of cinnamon

3) Pelleting: taking fine powder 1/20, and taking a mold by using purified water, wherein the particle size of the mold is as follows: 1mm, fine powder is sieved out, and pelleting is carried out, wherein the air blowing amount of a pelleting machine is 20Hz, the temperature is 40 ℃, and the rotating speed is 30 revolutions per minute: the feeding powder is 1/3-1/2 of the weight of the mold each time, the purified water is in a fine mist shape, the atomization pressure is 0.9Bar, and the liquid spraying speed is 8 ml/min; processing the balls to the diameter of 5-6 mm; keeping the temperature at 60 ℃ and rotating at 40 r/min for drying and rounding. All pelleting environments are required to be carried out in a hundred thousand grade purification area so as to ensure the sanitation and cleanness of the sachet pills.

example 3

mint 8 parts

6 portions of angelica dahurica

Rhizoma Nardostachyos 6 parts

1 part of clove

Kaempferia galanga 4 parts

1 part of sandalwood

Herba Moslae 6 parts

Folium Artemisiae Argyi 4 parts

2 portions of cinnamon

2) Crushing: pulverizing the raw materials at a certain ratio, adding soaking materials (herba Menthae and folium Artemisiae Argyi) and mixing with middle-grade materials (herba Moslae, rhizoma Kaempferiae, rhizoma Nardostachyos, flos Caryophylli and cortex Cinnamomi), homogenizing, and controlling the fineness of fine powder to 80 mesh (particle diameter of 0.25 mm).

3) Pelleting: taking fine powder 1/20, and taking a mold by using purified water, wherein the particle size of the mold is as follows: 1mm, fine powder is sieved out, and pelleting is carried out, wherein the air blowing amount of a pelleting machine is 20Hz, the temperature is 45 ℃, and the rotating speed is 30 revolutions per minute: the feeding powder is 1/3-1/2 of the weight of the mold each time, the purified water is in a fine mist shape, the atomization pressure is 1.0Bar, and the liquid spraying speed is 5 ml/min; processing the balls to 6mm in diameter; keeping the temperature at 40 ℃ and rotating at 30 r/min for drying and rounding. All pelleting environments are required to be carried out in a hundred thousand grade purification area so as to ensure the sanitation and cleanness of the sachet pills.

the following experiments and investigations prove that the invention has the advantages of the effects:

experiment A

In order to verify the efficacy and effect of the slow-release pellet sachet, the inventor researches the use population of the slow-release pellet sachet, and concretely comprises the following steps:

the method comprises the following steps:

the slow-release sachet 1600 is freely issued, the use opinions are informed to be fed back through the modes of telephone, WeChat, QQ, short message and the like, and the user can carefully and timely feed back the opinions, so that one newly-made product in the next year can be freely received.

Information feedback and statistics table:

name (I)

Sex

Age (age)

Application method

Effect of removing filth

Refreshing effect

Durability

(II) summarizing, analyzing and concluding the reports of the use of the crowd:

in order to determine the using effect of the slow-release sachet, the slow-release sachet 1600 is freely released in 2017.5-2018.2, the main objects of the slow-release sachet are women, children and the old, and 1278 feedback information is received by 2018.3.24. Wherein

1) And the slow-release sachet using population: 933 female, 345 male, 73% female; 362 children (less than or equal to 18 years old), 718 middle-aged people (19-60 years old), and 198 old people (more than or equal to 61 years old); the use method comprises the following steps: the portable bag is mainly worn by children (juvenile schoolbag and adult handbag), placed on a vehicle, placed in an office and placed at home, and the portable bag is generally worn for 1-3 months, and the rest is placed for more than 9 months.

2) And the using effects of the slow-release sachet are summarized: the effect of avoiding dirt: 73% valid, possibly 18% valid, 11% invalid; refreshing effect: 81% active, possibly 13% active, 6% inactive. More than 70% of people feed back: after experiencing influenza season, plum season and summer high-temperature season, the slow-release sachet still has fragrant smell, no stimulation and obvious refreshing effect.

It can be seen from this that: the slow-release sachet has definite and lasting effect of removing dirt and refreshing mind.

Experiment B

In order to verify the slow release stability of the slow release sachet, the inventor inspects the slow release effect and stability of the slow release pellet sachet, and the slow release effect and stability are as follows:

designing an experimental scheme:

the main components of the main raw materials in the sachet are volatile oil, such as: the stability of the slow release effect is inspected, and the volatile oil is taken as an index, so that the inspection is remarkable and easy; meanwhile, the angelica dahurica contains imperatorin, can be subjected to high performance liquid phase fine measurement, and can be used for proving the slow release effect.

And (3) slow release stability investigation: for drug stability, the test was conducted in a constant temperature and humidity chamber (37 ℃ C., 75% humidity). Samples were taken once a week for 9 consecutive weeks to investigate their sustained release effect and stability.

(I) test materials

1. The slow-release pellet type sachet 120 is manufactured by Hangzhou Huqingyutang Natural food Co.

2. Analytical balance (10)

2. Volatile oil measuring device set

3. One constant temperature and humidity box

4. Pharmacopeia standard sieve set

5. High performance liquid chromatograph

6. Comparison products: imperatorin (Chinese biological products inspection institute)

7. Reagent: xylene (chemical purity), methanol (analytical purity)

(II) Experimental method

1. And (3) volatile oil determination:

and (3) crushing the slow-release sachet pills for determination so that the pills can pass through a No. two to No. three sieve, and uniformly mixing. Taking about 300ml of water and a plurality of glass beads, placing the water and the glass beads in a flask, and connecting with a volatile oil tester. Water was added from the upper end of the measuring device to fill the scale portion and overflowed into the flask, and 1ml of xylene was added by a pipette, followed by connecting a reflux condenser tube. The flask contents were heated to boiling and distillation continued at a rate to maintain the middle of the condenser tube in a cooled state. After 30 minutes, the heating was stopped, and the reaction mixture was left for 15 minutes or more to read the volume of xylene. And weighing about 20g of the sustained-release pill (accurately to 0.01g), putting the sustained-release pill into a flask, adding 300-500 ml (or a proper amount) of water and a plurality of glass beads, shaking and mixing, and connecting a volatile oil tester and a reflux condenser tube. Adding water from the upper end of the condensation tube to fill the graduated part of the volatile oil detector and overflow into the flask. Placing in an electric heating jacket or slowly heating to boil by other suitable methods, maintaining slightly boiling for about 5 hr until the oil amount in the detector is not increased, stopping heating, placing for a moment, starting a piston at the lower end of the detector, and slowly discharging water until the upper end of the oil layer reaches 5mm above the 0 line of the scale. Standing for more than 1 hr, opening the piston to lower the oil layer to the level with the scale 0, reading the volatile oil amount, subtracting the xylene amount from the oil layer to obtain the volatile oil amount, and calculating the volatile oil content (%).

FIG. 1 is a schematic view of a volatile oil measuring apparatus; FIG. A shows a 1000ml (or 500ml, 2000ml) rigid round-bottom flask, which is connected with a volatile oil tester B, and the upper end of the tester B is connected with a reflux condenser C. All the parts are connected by a glass ground. The meter B should have a scale of 0.1 ml. All instruments should be thoroughly cleaned and the joints checked for tightness to prevent escape of volatile oil.

2. Imperatorin assay:

measuring by high performance liquid chromatography (general rule of Chinese pharmacopoeia 0512). Octadecylsilane chemically bonded silica is used as a filler in chromatographic conditions and system applicability tests; methanol-water (55: 45) is used as a mobile phase; the detection wavelength was 300 nm. The number of theoretical plates should not be less than 3000 calculated according to imperatorin peak. Preparation of reference solution A proper amount of imperatorin reference is precisely weighed, and methanol is added to obtain a solution containing 10 μ g of imperatorin per 1 ml. Preparation of test solution about 0.4g of the sustained-release pill (passing through a third sieve) is precisely weighed, placed in a 50ml measuring flask, added with 45ml of methanol, ultrasonically treated (power 300W, frequency 50kHz) for 1 hour, taken out, cooled, added with methanol to scale, shaken up, filtered, and a subsequent filtrate is taken, thus obtaining the test solution. The determination method comprises precisely sucking 20 μ l of each of the reference solution and the sample solution, injecting into liquid chromatograph, and determining.

(III) results of the experiment

(IV) conclusion

The slow-release pill stability investigation result is as follows: the volatile oil and imperatorin are stable and durable in diffusion and have the effect of stabilizing efficacy.

The foregoing is illustrative of only a few specific embodiments of the invention. It is obvious that the present invention is not limited to the above embodiments, but many variations are possible, and all variations that can be derived or suggested by a person skilled in the art from the disclosure of the present invention should be considered as the protection scope of the present invention.

Claims

1. A stable slow-release sachet with the functions of removing dirt and refreshing mind is characterized in that the sachet comprises the following raw material medicines: the sachet comprises the following components in parts by weight:

4 portions of mint

4 portions of angelica dahurica

3 portions of nard

2 portions of clove

Kaempferia galanga 2 parts

4 portions of sandalwood

Herba Moslae 2 parts

2 parts of folium artemisiae argyi

1 part of cinnamon;

the preparation method of the sachet comprises the steps of material selection and detection, drying and crushing, pelleting, inspection and packaging, and specifically comprises the following preparation steps:

5) packaging: packaging after all the items are qualified, wrapping the heat-sealed filter paper bag containing the material pills with clean elastic wadding after being folded, filling the bag into a sachet, boxing and warehousing;

in the step 1), the raw material volatile oil is controlled: more than 0.40 percent of volatile oil in mint, more than 0.080 percent of imperatorin in angelica dahurica, more than 2.0 percent of volatile oil in nardostachys root, more than 4.5 percent of volatile oil in kaempferia galanga, more than 3.0 percent of volatile oil in sandalwood, more than 0.16 percent of thymol in elsholtzia and carvacrol in total, more than 0.050 percent of eucalyptol in folium artemisiae argyi, more than 11.0 percent of eugenol in clove and more than 1.5 percent of cinnamaldehyde in cinnamon; the low temperature of the low-temperature drying is less than or equal to 60 ℃;

in the step 2), the powdering sequence is as follows: pulverizing radix Angelicae Dahuricae and lignum Santali albi with heavy weight, adding herba Menthae and folium Artemisiae Argyi, soaking, and mixing with herba Moslae, rhizoma Kaempferiae, rhizoma Nardostachyos, flos Caryophylli and cortex Cinnamomi to obtain powder;

the specific preparation steps of the step 3) are as follows: taking 1/20 fine powder, using purified water to take a mould, screening out the fine powder, carrying out pelleting, wherein the air blast volume of a pelleting machine is 20Hz, the temperature is 30-45 ℃, the rotating speed is 20-30 r/min, the feeding powder is 1/3-1/2 of the weight of the mould each time, the purified water is in a fine mist shape, the atomizing pressure is 0.8-1.0Bar, the liquid spraying speed is 5-8ml/min, and the diameter of the pellets is 5-6 mm; continuously keeping the temperature at 40-60 ℃, drying and rounding at the rotating speed of 30-45 r/min, wherein all pelleting environments are required to be carried out in a hundred thousand grade purification area;

the prepared ball is as follows: brown round pellets in appearance: diameter of 5-6mm, water content of 5.2%, disintegration time of 18 min, and volatile oil content of 2.7%.