CN108403845A - A kind of Chinese medicine composition of prevention motion sickness - Google Patents
A kind of Chinese medicine composition of prevention motion sickness Download PDFInfo
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Abstract
The invention discloses a kind of Chinese medicine compositions of prevention motion sickness, are made of following raw material medicaments:Ginseng, rhizoma atractylodis, Rhizoma Atractylodis Macrocephalae, wrinkled giant hyssop, peppermint, Radix Salviae Miltiorrhizae, Radix Paeoniae Alba, the dried immature fruit of citron orange, radix rehmanniae recen and root of Aucklandia lappa Decne.The dosage form of Chinese medicine composition of the present invention can be medically acceptable any dosage form.The invention also includes purposes of the Chinese medicine composition in preparing the drug for preventing motion sickness.Chinese medicine composition using the present invention can significantly prevent motion sickness, Chinese medicine composition ascending the clear and descending the turbid of the invention, relieving and eliminating mass, and stomach invigorating is amusing, and people's spirit and QI cleaning, righting is allowed to get rid of evils.Integral formula Yin Yang balancing, without any side effects and any discomfort feeling.Monarch is made a clear distinction between good and evil, and the function for fully taking into account each medicine cures mainly and medication taboo, is the indispensable good medicine for solving people's trip.Chinese medicine composition of the present invention is prepared simply, without toxic side effect, is worth clinically promoting and applying.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicines, the Chinese medicine composition of specifically a kind of prevention motion sickness.
Background technology
Carsickness is medically known as " motion sickness ", and ride public transportation means such as vehicle, ship, aircraft will appear the disease of motion sickness
Shape, different from the disease on ordinary meaning, it is only emergency reaction of the sensitive body to supermaximal stimulus.It with before our inner ears
It is the receptor that inner ear experiences positive and negative rotary acceleration that front yard statoreceptor official, which has direct relation, semicircular canal, when semicircular canal is to thorn
Swash tetchiness or when by strong stimulation, a series of independence functional responses can be caused, by bus when dizzy even vomit.Some
Because sleep is poor, overworked, polyorexia is satiated, suffers from certain ear diseases carsick phenomenon occurs often for people, some normal people take traffic
Soon just feel dizzy after tool, upper abdomen is uncomfortable, nauseous, cold sweat, or even vomiting;Especially when encounter bring to a halt, it is anxious
It is more severe when turning or suddenly starting, it rides public transportation means and finishes, taking a momentary rest gradually to mitigate or restore, serious symptom
People needs to rest for a few days and could restore.
Current treatment means mainly have drug therapy and operative treatment, doctor trained in Western medicine to carry out drug therapy and select antihistamine often
With anti-choline class drug, such as scopolamine hydrobromide, diphenhydramine, Betahistine Hydrochloride, meclozine hydrochloride, these drugs
The side effects such as drowsiness, dry, fatigue are often accompanied by, it is more using contraindication, and be not suitable for taking for a long time;Chinese medicine carries out drug therapy
Chinese medicine it is more, but the drug of certain toxicity is added in many prescriptions, there is also the side effects such as drowsiness fatiguability;Operation is controlled
Less progress is treated, has the risk for generating serious sequelae, patient compliance bad after row neurotomy of vestibular nerve.
Invention content
Technical problem to be solved by the present invention lies in, it is small to provide a kind of toxic side effect, good drug efficacy and it is special long, it is at low cost
For preventing the Chinese medicine composition of motion sickness.
A kind of Chinese medicine composition of prevention motion sickness of the present invention, is made of following raw material medicaments:It is ginseng, rhizoma atractylodis, white
Art, wrinkled giant hyssop, peppermint, Radix Salviae Miltiorrhizae, Radix Paeoniae Alba, the dried immature fruit of citron orange, radix rehmanniae recen and root of Aucklandia lappa Decne.
Preferably, described pharmaceutical composition is made of the bulk pharmaceutical chemicals of following weight parts:5~15 parts of ginseng, rhizoma atractylodis 5~20
Part, 5~15 parts of Rhizoma Atractylodis Macrocephalae, 5~15 parts of wrinkled giant hyssop, 5~15 parts of peppermint, 5~20 parts of Radix Salviae Miltiorrhizae, 5~15 parts of Radix Paeoniae Alba, 5~20 parts of the dried immature fruit of citron orange, life
5~15 parts of 5~20 parts of glutinous rehmannia and root of Aucklandia lappa Decne.
Preferably, described pharmaceutical composition is made of the bulk pharmaceutical chemicals of following weight parts:12 parts of ginseng, 15 parts of rhizoma atractylodis, in vain
12 parts of 12 parts of art, 10 parts of wrinkled giant hyssop, 10 parts of peppermint, 15 parts of Radix Salviae Miltiorrhizae, 12 parts of Radix Paeoniae Alba, 15 parts of the dried immature fruit of citron orange, 15 parts of radix rehmanniae recen and root of Aucklandia lappa Decne.
The dosage form of Chinese medicine composition of the present invention can be decoction, tablet, granule, capsule, oral solution, paste or
The medically acceptable dosage form such as pill, their preparation method, supplementary product consumption are carried out by existing common process.
The invention also includes purposes of the Chinese medicine composition in preparing the drug for preventing motion sickness.
Each component raw material effect is as follows in the Chinese medicine composition of the present invention:
1, ginseng:Sweet, slight bitter, tepor;Returns spleen, lung, the heart, kidney channel;It reinforces vital energy, veins takes off admittedly reinforces the spleen to benefit the lung, and promotes the production of body fluid foster
Blood, tranquilize the mind and promote the intelligence;It to be taken off for physically weak, cold weak pulse of limb, spleen eating less, the deficiency syndrome of the lung is breathed with cough, injury thirst, Heat Diabetes, and qi and blood loses
Void, prolonged illness void is thin, insomnia of palpitating with fear, impotence Gong Leng.
2, rhizoma atractylodis:It is pungent, bitter, temperature;Returns spleen, stomach, Liver Channel;Eliminating dampness Jian spleens, expelling wind and clearing away cold, improving eyesight;For damp retention in middle-jiao, gastral cavity abdomen
Turgor, diarrhea, oedema, tinea pedis Wei Cu, arthralgia pain due to rheumatism, anemofrigid cold, yctalopia, eyes dusk are puckery.
3, Rhizoma Atractylodis Macrocephalae:Bitter, sweet, warm;Returns spleen, stomach;Jian spleen QI invigorating, eliminate dampness and have diuretic effect, hidroschesis;For spleen Virtual deficiency of food, abdominal distension is let out
It rushes down, phlegm retention anti-dazzle nervous, oedema, spontaneous perspiration.
4, wrinkled giant hyssop:From the dry aerial parts of labiate wrinkled giant hyssop, have and eliminate dampness with aromatics, whet the appetite preventing or arresting vomiting, delivers
The work(of relieving summer-heat is used for turbi damp obstructing in middle-JIAO, and the vomiting of gastral cavity ruffian, summer-heat and damp burnout is uncomfortable in chest not relax, and cold-dampness closes heat, and abdominal pain is vomited and diarrhoea, nasosinusitis headache.
5, peppermint:It is pungent, it is cool;Return lung, Liver Channel;Dispelling wind and heat from the body, head clearing, relieving sore-throat, promoting eruption, soothing the liver promoting the circulation of qi;For wind-heat
Flu, wind-warm syndrome from the beginning of, headache, hot eyes, larynx numbness, aphtha, rubella, measles, Breast bilges frowsty.
6, Radix Salviae Miltiorrhizae:Hardship is slightly cold;Converge to heart and liver channels;Promoting blood circulation, inducing meastruation to relieve menalgia, relieving restlessness that clears away heart-fire, cool blood to disappear carbuncle.For the obstruction of qi in the chest
It is pained, gastral cavity abdomen hypochondriac pain , lumps in the chest and abdomen, hot numbness pain, dysphoria and insomnia, sore Ulcers swelling and pain.
7, Radix Paeoniae Alba:Bitter, acid, is slightly cold;Return liver, the spleen channel;Nourishing blood for regulating menstruation, astringing YIN to stop sweating, soft liver analgesic, suppressing liver-YANG;For
Blood deficiency chlorosis, irregular menstruation, spontaneous perspiration, night sweat, hypochondriac pain, abdominal pain, four limbs contraction pain, dizziness of having a headache.
8, the dried immature fruit of citron orange:It is bitter, pungent, sour, it is slightly cold;Returns spleen, stomach;Relieving stagnant Qi disperse accumulation, resolving sputum dissipate ruffian.For internal stagnation, feeling of fullness is swollen
Bitterly, weight after rush down dysentery, constipation, the resistance of phlegm stagnant gas, the obstruction of qi in the chest, accumulation of pathogens in chest, visceral organ ptosis.
9, radix rehmanniae recen:It is sweet, bitter, it trembles with fear;The thoughts of returning home, liver and kidney channel;The hot cool bloods of Cheongju, nourishing Yin and promoting production of body fluid.For thermal man's ying blood, epidemic heat syndrome hair
Spot, hematemesis and epistaxis, consumption of YIN caused by febrile disease, the deep red polydipsia of tongue, Tianjin hinder constipation, fever due to yin deficiency, hectic fever due to yin labor heat, Heat Diabetes.
10, root of Aucklandia lappa Decne:It is pungent, bitter, temperature;Returns spleen, stomach, large intestine, three burnt, gallbladder channels;Promoting qi circulation and relieving pain, reinforcing spleen to promote digestion;For chest side of body, gastral cavity
Abdominal distention and pain, weight after rush down dysentery, dyspepsia, do not feel like eating;Roasted RADIX AUCKLANDIAE reality intestines antidiarrheal is used for stomachache of having loose bowels.
Compared with prior art, advantages of the present invention and generation good effect are:
The present invention targetedly has chosen Ten Herbs material and carries out reasonable compatibility, has the work(of significantly prevention motion sickness
Effect when motion-sick person being made to take all kinds of vehicles, from the invasion of chill summer-heat and damp, to seasick carsickness, and then is vomitted and is disliked
The heart is more than or big apogee sweating, the card of the physically weak or diarrhea of body weight all discomforts such as incessantly.
The Chinese medicine composition ascending the clear and descending the turbid of the present invention, relieving and eliminating mass, stomach invigorating are amusing, and people's spirit and QI cleaning, righting is allowed to get rid of evils.It is whole
Body balance formula negative and positive, without any side effects and any discomfort feeling.Monarch is made a clear distinction between good and evil, and each medicine is fully taken into account
Function cure mainly and medication taboo, be solve people trip indispensable good medicine.
The Chinese medicine composition of the present invention is prepared simply, and without toxic side effect, good effect, short treating period can help to swoon in time
Dynamic patient is worth clinically promoting and applying.
Specific implementation mode
The technical scheme in the embodiments of the invention will be clearly and completely described below.Based on the reality in the present invention
Example is applied, every other embodiment obtained by those of ordinary skill in the art without making creative efforts all belongs to
In the scope of protection of the invention.
Embodiment
Embodiment 1
Each bulk pharmaceutical chemicals are weighed by following parts by weight:5 parts of ginseng, 5 parts of rhizoma atractylodis, 5 parts of Rhizoma Atractylodis Macrocephalae, 5 parts of wrinkled giant hyssop, 5 parts of peppermint are red
5 parts of 5 parts of ginseng, 5 parts of Radix Paeoniae Alba, 5 parts of the dried immature fruit of citron orange, 5 parts of radix rehmanniae recen and root of Aucklandia lappa Decne.
Above-mentioned each taste bulk pharmaceutical chemicals are mixed and are placed in marmite, five bowls are decocted in water for oral dose, and remove the dregs of a decoction, obtain liquid.
Embodiment 2
Each bulk pharmaceutical chemicals are weighed by following parts by weight:12 parts of ginseng, 15 parts of rhizoma atractylodis, 12 parts of Rhizoma Atractylodis Macrocephalae, 10 parts of wrinkled giant hyssop, peppermint 10
12 parts of part, 15 parts of Radix Salviae Miltiorrhizae, 12 parts of Radix Paeoniae Alba, 15 parts of the dried immature fruit of citron orange, 15 parts of radix rehmanniae recen and root of Aucklandia lappa Decne.
Above-mentioned each taste bulk pharmaceutical chemicals are mixed and are placed in marmite, five bowls are decocted in water for oral dose, and remove the dregs of a decoction, obtain liquid.
Embodiment 3
Each bulk pharmaceutical chemicals are weighed by following parts by weight:15 parts of ginseng, 20 parts of rhizoma atractylodis, 15 parts of Rhizoma Atractylodis Macrocephalae, 15 parts of wrinkled giant hyssop, peppermint 15
15 parts of part, 20 parts of Radix Salviae Miltiorrhizae, 15 parts of Radix Paeoniae Alba, 20 parts of the dried immature fruit of citron orange, 20 parts of radix rehmanniae recen and root of Aucklandia lappa Decne.
Above-mentioned each taste bulk pharmaceutical chemicals are mixed and are placed in marmite, five bowls are decocted in water for oral dose, and remove the dregs of a decoction, obtain liquid.
Animal toxicology is tested
1, animal acute toxicity test
1. drug:Decoction is boiled according to Chinese prescription of the present invention, is then placed into refrigerator and saves backup, by Hunan Province
Hospital provides.
2. experimental animal:Small white mouse, weight are provided in 30~50g, male and female random selection by institute of traditional Chinese medicine of Hunan Province.
3. method and result:Small white mouse 50 is taken, is divided into 5 groups, every group 10, starvation 15 hours or so is each by every
20ml feeds drug, the 1st, 2,3,4,5 group fed in 24 hours respectively drug 1,2,3,4,5 times, observe 5 days, small white mouse lives
It is dynamic normal, non-toxic reaction, no death.Wherein, small white mouse dosage presses kg body weight medicine calculation, shows oral solution without acute
Toxicity, clinical medicine dose safety.
2, long-term toxicity test for animals
1. drug:Decoction is boiled according to Chinese prescription of the present invention, is then placed into refrigerator and saves backup, by Hunan Province
Hospital provides.
2. experimental animal:Big white mouse, weight all select male white rat, are carried by institute of traditional Chinese medicine of Hunan Province in 120~130g
For.
3. method and result:Big white mouse 50 is taken, is divided into 5 groups, every group 10, wherein the 1st, 2,3,4 group is used as administration group,
Every group feeds drug 15ml, 20ml, 30ml, 40ml respectively, and the 5th group of diet is as a control group, once a day, continuous to fill
It feeds 90 days, surveys weight, 24 hours sacrificed by decapitation after last time is administered, survey blood, routine urinalysis, liver function, renal function, coring,
The effect of dosage, observation diet, movable variation, experiments have shown that administration group are observed in the internal organ such as kidney, the variation of tissues observed form
Compared with the control group without significant changes, it is seen that calculated by kg body weight non-toxic anti-relative to clinical 50~200 times of dosage
It answers, is a kind of safe drugs.
Observation on Clinical Application is reported
One, basic document (in July, 2014~2017 year July)
In order to verify clinical efficacy, by randomly selecting the Patients with 300 Cases with cinetosis medical history, in the present embodiment 1~3
Traditional Chinese herbal decoction tried out, wherein 18~65 years old age, average 32 years old, male 168 people, 132 people of female, without gasoline allergies.
Two, instructions of taking
1 dose every time, the ten minutes prosopyles that ride public transportation means take 30 milliliters.
Avoid item:Food frying greasy, solid hard cold and stodgy food etc., diabetic should be lacked during medication
It removes brown sugar to use, child is cut down according to the circumstance, and pregnant woman uses with caution.
Three, criterion of therapeutical effect
It is effective:Cinetosis symptom does not occur for patient;Effectively:Patient feels that cinetosis symptom mitigates;In vain:Patient's cinetosis symptom is not
Mitigate.
Four, therapeutic effect
Embodiment 1:Effective 252, effective 48, invalid example 0, obvious effective rate 84%, effective percentage is 100%.Specific feelings
Condition is as follows:
The vehicles | Experiment number | Effective number | Efficiently individual quantity | Invalid number |
Automobile | 151 | 132 | 22 | 0 |
Train | 67 | 51 | 7 | 0 |
Aircraft | 43 | 39 | 12 | 0 |
Steamer | 39 | 30 | 7 | 0 |
It is total | 300 | 252 | 48 | 0 |
Embodiment 2:Effective 261, effective 39, invalid example 0, obvious effective rate 87%, effective percentage is 100%.Specific feelings
Condition is as follows:
The vehicles | Experiment number | Effective number | Efficiently individual quantity | Invalid number |
Automobile | 148 | 139 | 12 | 0 |
Train | 51 | 43 | 9 | 0 |
Aircraft | 72 | 59 | 10 | 0 |
Steamer | 29 | 20 | 8 | 0 |
It is total | 300 | 261 | 39 | 0 |
Embodiment 3:Effective 258, effective 42, invalid example 0, obvious effective rate 86%, effective percentage is 100%.Specific feelings
Condition is as follows:
The vehicles | Experiment number | Effective number | Efficiently individual quantity | Invalid number |
Automobile | 124 | 119 | 12 | 0 |
Train | 69 | 52 | 10 | 0 |
Aircraft | 32 | 20 | 9 | 0 |
Steamer | 75 | 67 | 11 | 0 |
It is total | 300 | 258 | 42 | 0 |
Model case
Case 1
Mrs Zhao, 21 years old, people from Zhuhai City, Guangdong Province had more serious airsick history, and once taking Betahistine Hydrochloride has seriously
Drowsiness side effect, it is difficult to it is independent to take long distance transportation tool, the liquid prepared by Chinese medicine composition of the present invention is taken before boarding,
Airsick symptom obviously disappears, and has no drowsiness equal adverse reactions.
Case 2
Mrs Tang, 37 years old, Hunan Province from Loudi had more serious carsick history, after riding public transportation means, can continue to vomit,
The liquid prepared by Chinese medicine composition of the present invention is before taken by bus, and carsick symptom obviously disappears, and it is bad anti-to have no vomiting etc.
It answers, gets off after resting 1 hour, have not yet to see any carsick symptom.
Case 3
Model man, 52 years old, people from ChangSha, Hunan Province had more serious seasick history, once took diphenhydramine have it is serious drowsiness
Side effect after riding public transportation means, can also continue to vomit, before take the liquid prepared by Chinese medicine composition of the present invention by bus, swoon
Vehicle symptom obviously disappears, and has no the adverse reactions such as drowsiness, vomiting.
Above-described embodiment is only the more excellent embodiment of the present invention, every according to the technical essence of the invention to implementing above
Any simple modification, modification and the alternate variation that example is made, belong in the range of technical solution of the present invention.
Claims (5)
1. a kind of Chinese medicine composition of prevention motion sickness, which is characterized in that be made of following raw material medicaments:Ginseng, rhizoma atractylodis, Rhizoma Atractylodis Macrocephalae,
Wrinkled giant hyssop, peppermint, Radix Salviae Miltiorrhizae, Radix Paeoniae Alba, the dried immature fruit of citron orange, radix rehmanniae recen and root of Aucklandia lappa Decne.
2. a kind of Chinese medicine composition of prevention motion sickness according to claim 1, which is characterized in that described pharmaceutical composition
It is made of the bulk pharmaceutical chemicals of following weight parts:5~15 parts of ginseng, 5~20 parts of rhizoma atractylodis, 5~15 parts of Rhizoma Atractylodis Macrocephalae, 5~15 parts of wrinkled giant hyssop are thin
5~15 parts of 5~15 parts of lotus, 5~20 parts of Radix Salviae Miltiorrhizae, 5~15 parts of Radix Paeoniae Alba, 5~20 parts of the dried immature fruit of citron orange, 5~20 parts of radix rehmanniae recen and root of Aucklandia lappa Decne.
3. a kind of Chinese medicine composition of prevention motion sickness according to claim 1, which is characterized in that described pharmaceutical composition
It is made of the bulk pharmaceutical chemicals of following weight parts:12 parts of ginseng, 15 parts of rhizoma atractylodis, 12 parts of Rhizoma Atractylodis Macrocephalae, 10 parts of wrinkled giant hyssop, 10 parts of peppermint, Radix Salviae Miltiorrhizae
15 parts, 12 parts of Radix Paeoniae Alba, 15 parts of the dried immature fruit of citron orange, 12 parts of 15 parts of radix rehmanniae recen and root of Aucklandia lappa Decne.
4. such as a kind of Chinese medicine composition of prevention motion sickness of claims 1 to 3 any one of them, which is characterized in that the medicine
Compositions can be any one in decoction, tablet, granule, capsule, oral solution, paste or pill.
5. such as a kind of Chinese medicine composition of prevention motion sickness of claims 1 to 3 any one of them, which is characterized in that in described
Purposes of the drug composition in preparing the drug for preventing motion sickness.
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谭庆佳: "保济丸治疗梅核气19例 ", 《湖北中医杂志》 * |
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