CN108403784A - It is a kind of to be used to improve eye sticker of eyesight and preparation method thereof - Google Patents

It is a kind of to be used to improve eye sticker of eyesight and preparation method thereof Download PDF

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Publication number
CN108403784A
CN108403784A CN201810558256.2A CN201810558256A CN108403784A CN 108403784 A CN108403784 A CN 108403784A CN 201810558256 A CN201810558256 A CN 201810558256A CN 108403784 A CN108403784 A CN 108403784A
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parts
eye sticker
borneol
improving eyesight
eye
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CN201810558256.2A
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陈帝江
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Guangzhou Chen Jin Ji Biotechnology Co Ltd
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Guangzhou Chen Jin Ji Biotechnology Co Ltd
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Priority to CN201810558256.2A priority Critical patent/CN108403784A/en
Publication of CN108403784A publication Critical patent/CN108403784A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/35Caprifoliaceae (Honeysuckle family)
    • A61K36/355Lonicera (honeysuckle)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/482Cassia, e.g. golden shower tree
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/63Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A61K36/638Ligustrum, e.g. Chinese privet
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/69Polygalaceae (Milkwort family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/10Ophthalmic agents for accommodation disorders, e.g. myopia

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses a kind of eye sticker for improving eyesight, which is prepared using following component:Cassia seed, borneol, honeysuckle flowers, the fruit of glossy privet, Radix Polygalae, cortex albiziae;The invention also discloses a kind of eye sticker preparation methods for improving eyesight.The eye sticker of the present invention improve significantly for myopia and meanwhile to eye sleepy, photophobia, ache, shed tears, the asthenopias symptom such as foreign body sensation, the dry and astringent, ophthalmospasm of eye has certain alleviation and auxiliary treatment, play the role of eyeshield, while will not eyes be caused with uncomfortable or injury circumference of eyes skin;The preparation method is filtered using drug component after the immersion of borneol essential oil, and technological process is simple, and product safety has no toxic side effect.

Description

It is a kind of to be used to improve eye sticker of eyesight and preparation method thereof
Technical field
The present invention relates to a kind of tcm field more particularly to a kind of eye stickers and preparation method thereof for improving eyesight.
Background technology
Near-sighted common cause is excess eye-using, body consumptive disease, eating and drinking without temperance, and vital organs of the human body vital essence is insufficient, can not support eye Portion.Its pathogenic factors is also related with heredity, development, environmental factor, is at present group of people at high risk with teenager, mostly by adolescents with learning Or longevity of service, caused by asthenopia or congenital heredity.The harm performance that myopia generates can be weighed gently, and less serious case shows as regarding object Phenomena such as fuzzy, eyes are dry and astringent to ache, spirit is difficult to concentrate, even dizzy, influences to learn and live, severe one causes retinopathy Become, the severe complications such as retinal detachment, glaucoma, vitreum deformation can be caused, even result in blindness, and can entail next Generation.
The method of the myopia of China's treatment at present has local atropine drug therapy, laser surgery treatment, extract oral to control It treats, four kinds of point massage therapy.Atropine treatment major defect is to have the side effects such as pupil expansion, photophobia, adjusting force reduction, easily The complication such as allergic conjunctivitis occur, affect promoting the use of for it;Low concentration solution few side effects, but curative effect is also poor. Laser therapy is not suitable for teenager, there is sequelae.Oral traditional Chinese medicine treatment cycle is long, unstable, and effect is relatively poor.Point massage Though effect is preferable in a short time, easily rebound, it cannot be lasting.Therefore seek to be when business to near-sighted drug effective and that side effect is less It is anxious.
Many natural drugs have a protective effect to human eye, however traditional administering mode, usually will directly apply In eye, or dropping liquid is made etc. and is administered, can eyes be caused with uncomfortable or injury since medicinal property is in direct contact eye Circumference of eyes skin.
Invention content
For overcome the deficiencies in the prior art, one of the objects of the present invention is to provide a kind of eyes for improving eyesight Patch, which improves significantly for myopia and meanwhile, photophobia sleepy to eye, ache, shed tears, foreign body sensation, eye are dry and astringent, The asthenopias symptom such as ophthalmospasm has certain alleviation and auxiliary treatment, plays the role of eyeshield, while will not cause discomfort to eyes Or injury circumference of eyes skin.
The second object of the present invention is to provide a kind of preparation method of Chinese medicine that treating hand-foot-and-mouth disease.
The purpose of the present invention adopts the following technical scheme that realization:
A kind of eye sticker for improving eyesight is prepared using each component as follows by weight:Cassia seed 5~15 Part, 5~15 parts of borneol, 7~15 parts of honeysuckle flowers, 7~15 parts of the fruit of glossy privet, 7~15 parts of Radix Polygalae, 7~15 parts of cortex albiziae.
Further, it is prepared using each component as follows by weight:8~13 parts of cassia seed, borneol 8~13 Part, 10~15 parts of honeysuckle flowers, 10~15 parts of the fruit of glossy privet, 10~15 parts of Radix Polygalae, 10~15 parts of cortex albiziae.
Further, it is prepared using each component as follows by weight:10~13 parts of cassia seed, borneol 10~13 Part, 12~15 parts of honeysuckle flowers, 12~15 parts of the fruit of glossy privet, 12~15 parts of Radix Polygalae, 12~15 parts of cortex albiziae.
Further, it is prepared using each component as follows by weight:10 parts of cassia seed, 10 parts of borneol, honeysuckle Spend 12 parts, 12 parts of the fruit of glossy privet, 12 parts of Radix Polygalae, 12 parts of cortex albiziae.
A kind of preparation method for improving the eye sticker of eyesight will be mixed to form mixture after the material slice in formula, Container of the mixture input equipped with borneol essential oil impregnates, the input ratio of the mixture and borneol essential oil for 0.5~ 1.5:30~45, temperature is 18~25 DEG C, and soaking time is 15~25 days, is then separated by solid-liquid separation, and removes solid, and it is former to obtain eye sticker Eye sticker raw material is penetrated into and obtains the eye sticker for improving eyesight in eye sticker carrier by material.
Further, the soaking time is 18 days.
Further, the input ratio of the mixture and borneol essential oil is 1:40.
Further, the separation of solid and liquid process is filtering-centrifugation, and centrifugation rotating speed is 1000r/min.
Compared with prior art, the beneficial effects of the present invention are:
The present invention is using cassia seed, borneol, honeysuckle flowers, the fruit of glossy privet, Radix Polygalae, cortex albiziae as raw material, by being optimized to subassembly And dosage, eye sticker is prepared, which has certain improvement result for myopia, asthenopia, the symptoms such as ache, and is often covered with and is conducive to Eyeshield, while stimulation will not be caused to injure to circumference of eyes skin, facilitates simple and direct, while the eye sticker preparation method is simple, raw material It is easy to get.
Specific implementation mode
In the following, in conjunction with specific implementation mode, the present invention is described further, it should be noted that is do not collided Under the premise of, new embodiment can be formed between various embodiments described below or between each technical characteristic in any combination.
A kind of eye sticker for improving eyesight is prepared using each component as follows by weight:Cassia seed 5~15 Part, 5~15 parts of borneol, 7~15 parts of honeysuckle flowers, 7~15 parts of the fruit of glossy privet, 7~15 parts of Radix Polygalae, 7~15 parts of cortex albiziae.In the proportioning Under, eye sticker provided by the invention can effective eyeshield, improve myopia symptoms.
As mode is further carried out, it is prepared using each component as follows by weight:Cassia seed 8~13 Part, 8~13 parts of borneol, 10~15 parts of honeysuckle flowers, 10~15 parts of the fruit of glossy privet, 10~15 parts of Radix Polygalae, 10~15 parts of cortex albiziae.
As mode is further carried out, it is prepared using each component as follows by weight:Cassia seed 10~13 Part, 10~13 parts of borneol, 12~15 parts of honeysuckle flowers, 12~15 parts of the fruit of glossy privet, 12~15 parts of Radix Polygalae, 12~15 parts of cortex albiziae.
As mode is further carried out, it is prepared using each component as follows by weight:10 parts of cassia seed, dragon 10 parts of brain, 12 parts of honeysuckle flowers, 12 parts of the fruit of glossy privet, 12 parts of Radix Polygalae, 12 parts of cortex albiziae.This proportioning is optimal embodiment, using this The proportioning of scheme have the effect of it is best, specifically show as can effectively eyeshield, improve myopia symptoms, while eye can also be alleviated Fatigue is ached, while minimum to circumference of eyes skin irritation.
As mode is further carried out, the eye sticker preparation method for improving eyesight is:By the material slice in formula After be mixed to form mixture, the container of the mixture input equipped with borneol essential oil impregnates, the mixture and borneol essential oil Input ratio is 0.5~1.5:30~45, temperature is 18~25 DEG C, and soaking time is 15~25 days, is then separated by solid-liquid separation, and is removed Solid obtains eye sticker raw material, and eye sticker raw material is penetrated into and obtains the eye sticker for improving eyesight in eye sticker carrier.Wherein borneol essential oil is by planting The distillation of object borneol camphor tree is extracted and is obtained, or manually borneolum syntheticum essential oil substitutes.
As the mode that further carries out, soaking time is 18 days.
As the mode that further carries out, the input ratio of mixture and borneol essential oil is 1:40.
As the mode that further carries out, separation of solid and liquid process is filtering-centrifugation, centrifuges rotating speed and is 1000r/min。
In the preparation method of eye sticker, formula materials slice mixing is impregnated 15~25 days in borneol essential oil, wherein when optimal Between be 18 days, temperature be 18~25 DEG C, material can be made fully to be impregnated in borneol essential oil, while in 18~25 DEG C of mixtures and dragon The volatility of brain essential oil soak is relatively low, wherein the volatility at a temperature of 20 DEG C is minimum, it to the full extent will be in formula materials Inclusion penetrates into borneol essential oil solution, while the input ratio of mixture and borneol essential oil is 0.5~1.5:30~45, wherein Best proportion is 1:40, it can make to match lower eye sticker irritation minimum obtained herein, while eyeshield effect is best;When separation of solid and liquid By the way of first filtering and centrifuging again, double filtration can make solid impurity filtering clean, obtain pure eye sticker raw material, wherein from It is that the separating effect that 1000r/min is obtained is best that the heart, which detaches rotating speed,.
Embodiment 1-5
It is specific embodiment of the present invention below, used raw material, equipment etc. remove special limit in the following embodiments It can be obtained by buying pattern outside fixed.
A kind of eye sticker for improving eyesight, specific component and dosage (parts by weight), then be specifically each parts by weight It is 1g in following embodiment 1-5, see the table below 1.
The eye sticker formula table for improving eyesight of 1 embodiment 1-5 of table
Embodiment 1 Embodiment 2 Embodiment 3 Embodiment 4 Embodiment 5
Cassia seed 10 5 8 13 15
Borneol 10 5 8 13 15
Honeysuckle flowers 12 7 10 15 15
The fruit of glossy privet 12 7 10 15 15
Radix Polygalae 12 7 10 15 15
Cortex albiziae 12 7 10 15 15
Embodiment 6
A kind of eye sticker preparation method for improving eyesight is:It will be mixed to form mixture after material slice in formula, Container of the mixture input equipped with borneol essential oil impregnates, the input ratio of the mixture and borneol essential oil for 0.5~ 1.5:30~45, temperature is 18~25 DEG C, and soaking time is 15~25 days, is then separated by solid-liquid separation, and removes solid, and it is former to obtain eye sticker Eye sticker raw material is penetrated into and obtains the eye sticker for improving eyesight in eye sticker carrier by material.
As the mode that further carries out, the input ratio of the mixture and borneol essential oil is 1:40, temperature is 20 DEG C, Soaking time is 18 days.
Verify embodiment
The present invention counts A nearsighted person 600 altogether, and age bracket is between 15~50 years old, slight myopic (4.70 ± 0.25) 125 people, 253 people of medium myopia (4.40 ± 0.25), 222 people of laser high myopia (4.10 ± 0.25), are classified as 2 groups, pilot scale It tests group to treat by the eye sticker of table one embodiment, 1 group of preparation, another group is control group, and course for the treatment of 60 days, daily night sticks one Patch, is tested eyesight using standard logarithmic visual acuity chart, and optometry is surveyed eyesight and is responsible for by special messenger, to eliminate caused by different gaugers partially It leans on, uncorrected visual acuity measures and registration before docking treated A nearsighted person's row treatment, after treatment;Alleviate simultaneously regarding tired to improving Labor, eye are swollen, eye is puckery, shouting pain etc. is evaluated.
Evaluation criterion is:
Recovery from illness:Symptom disappears or basic disappearance;
Effectively:Symptom makes moderate progress;
In vain:Symptom is not improved, even it aggravates.
The pretherapy and post-treatment eyesight of 2 A nearsighted person of table compares
As a result, it has been found that control group eyesight during experiment is not improved or changes, and test group in application eye sticker It after one course for the treatment of, is shown according to 2 data of table, eyesight returns to normal slight myopic patient after the treatment, while moderate and again Eyesight has clear improvement degree A nearsighted person after the treatment;In the evaluation to visual fatigue, there is 34.62% patient in application one It fully recovers after the course for the treatment of, 65.38% symptom makes moderate progress, and is in vain 0.
The above embodiment is only the preferred embodiment of the present invention, and the scope of protection of the present invention is not limited thereto, The variation and replacement for any unsubstantiality that those skilled in the art is done on the basis of the present invention belong to institute of the present invention Claimed range.

Claims (8)

1. a kind of eye sticker for improving eyesight, which is characterized in that be prepared using following each component by weight:Certainly 5~15 parts of pine torch, 5~15 parts of borneol, 7~15 parts of honeysuckle flowers, 7~15 parts of the fruit of glossy privet, 7~15 parts of Radix Polygalae, cortex albiziae 7~15 Part.
2. the eye sticker as described in claim 1 for improving eyesight, which is characterized in that using following each group by weight Divide and is prepared:8~13 parts of cassia seed, 8~13 parts of borneol, 10~15 parts of honeysuckle flowers, 10~15 parts of the fruit of glossy privet, Radix Polygalae 10~15 Part, 10~15 parts of cortex albiziae.
3. the eye sticker as described in claim 1 for improving eyesight, which is characterized in that using following each group by weight Divide and is prepared:10~13 parts of cassia seed, 10~13 parts of borneol, 12~15 parts of honeysuckle flowers, 12~15 parts of the fruit of glossy privet, Radix Polygalae 12~ 15 parts, 12~15 parts of cortex albiziae.
4. the eye sticker as described in claim 1 for improving eyesight, which is characterized in that using following each group by weight Divide and is prepared:10 parts of cassia seed, 10 parts of borneol, 12 parts of honeysuckle flowers, 12 parts of the fruit of glossy privet, 12 parts of Radix Polygalae, 12 parts of cortex albiziae.
5. the eye sticker preparation method as described in claim 1 for improving eyesight, which is characterized in that cut the material in formula Mixture is mixed to form after piece, the container of the mixture input equipped with borneol essential oil impregnates, the mixture and borneol essential oil Input ratio be 0.5~1.5:30~45, temperature is 18~25 DEG C, and soaking time is 15~25 days, is then separated by solid-liquid separation, goes Except solid, eye sticker raw material is obtained, eye sticker raw material is penetrated into and obtains the eye sticker for improving eyesight in eye sticker carrier.
6. the eye sticker preparation method as claimed in claim 5 for improving eyesight, which is characterized in that the soaking time is 18 It.
7. the eye sticker preparation method as claimed in claim 5 for improving eyesight, which is characterized in that the mixture and borneol The input ratio of essential oil is 1:40.
8. the eye sticker preparation method as claimed in claim 5 for improving eyesight, which is characterized in that the separation of solid and liquid process For filtering-centrifugation, centrifugation rotating speed is 1000r/min.
CN201810558256.2A 2018-06-01 2018-06-01 It is a kind of to be used to improve eye sticker of eyesight and preparation method thereof Pending CN108403784A (en)

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108771715A (en) * 2018-08-27 2018-11-09 广州西科国际生物科技有限公司 Bright eye spraying of a kind of Chinese medicine and preparation method thereof
CN109620909A (en) * 2018-10-08 2019-04-16 车丽萍 Chinese medicine composition, Chinese medicine eye mask and its preparation and application
CN113332359A (en) * 2021-07-01 2021-09-03 西安陈锦济生物科技有限公司 Medicinal composition for vision correction protection and preparation method thereof
CN114191289A (en) * 2021-09-27 2022-03-18 吉林省中科医药产业集团有限公司 Hard mass incense for relieving eye diseases
CN114236877A (en) * 2021-12-26 2022-03-25 赣州安宏环保科技有限公司 Lens patch with effect of preventing and treating pain and dizziness of eyes watching mobile phone and computer and preparation method thereof

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108771715A (en) * 2018-08-27 2018-11-09 广州西科国际生物科技有限公司 Bright eye spraying of a kind of Chinese medicine and preparation method thereof
CN109620909A (en) * 2018-10-08 2019-04-16 车丽萍 Chinese medicine composition, Chinese medicine eye mask and its preparation and application
CN113332359A (en) * 2021-07-01 2021-09-03 西安陈锦济生物科技有限公司 Medicinal composition for vision correction protection and preparation method thereof
CN114191289A (en) * 2021-09-27 2022-03-18 吉林省中科医药产业集团有限公司 Hard mass incense for relieving eye diseases
CN114236877A (en) * 2021-12-26 2022-03-25 赣州安宏环保科技有限公司 Lens patch with effect of preventing and treating pain and dizziness of eyes watching mobile phone and computer and preparation method thereof

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