CN108402060B - High-content abamectin water dispersible granule and preparation method thereof - Google Patents
High-content abamectin water dispersible granule and preparation method thereof Download PDFInfo
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- CN108402060B CN108402060B CN201810344155.5A CN201810344155A CN108402060B CN 108402060 B CN108402060 B CN 108402060B CN 201810344155 A CN201810344155 A CN 201810344155A CN 108402060 B CN108402060 B CN 108402060B
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/12—Powders or granules
- A01N25/14—Powders or granules wettable
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- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
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Abstract
The invention relates to the technical field of pesticide preparation, and particularly discloses a high-content abamectin water dispersible granule and a preparation method thereof. The abamectin water dispersible granule comprises the following components in percentage by mass: 30-75% of abamectin, 3-5% of wetting agent, 6-8% of dispersing agent, 2-5% of anti-decomposition embedding agent, 2-4% of cosolvent and the balance of filler. The abamectin water dispersible granule prepared by the invention has high content of effective components, not only has the advantages of good suspension rate and short disintegration time, but also has the advantages of long lasting period and rain wash resistance, and the preparation method is simple to operate and is suitable for large-scale production operation.
Description
Technical Field
The invention relates to the technical field of pesticide preparation, and particularly relates to a high-content abamectin water dispersible granule and a preparation method thereof.
Background
The abamectin is a macrolide disaccharide compound, when the abamectin is used as an insecticide and a bactericide, a raw pesticide and a product obtained after metabolism thereof are easily decomposed, belong to pollution-free biological pesticides, enter China in the nineties of the last century, are rapidly popularized in China after 2000 years, and are mainly used as insecticides for preventing and treating rice stem borers and rice leaf rollers. According to statistics, the yield of China currently accounts for about 80% of the market share of the world, and is the first major producing and consuming country in the world.
The water dispersible granule is a pesticide formulation which is prepared into a dry pesticide formulation without dust, can freely flow and is easy to diffuse in water. Compared with other pesticide formulations, the water dispersible granule conforms to the development trend of pesticide formulation water-based, avoids using a large amount of organic solvents such as toluene and xylene, improves environmental compatibility, is safe for operators, and conforms to the development direction of energy conservation and emission reduction. The water dispersible granule has the advantages of both solid preparations (granules and wettable powder) and liquid preparations (suspending agents and the like), and is considered to be one of the most vital dosage forms in the 21 st century. At present, the research on abamectin water dispersible granules in China is less, the content of active ingredients in the existing abamectin water dispersible granules is low, the main reason is that abamectin is white crystal powder, and is not easy to crush when passing through a jet mill, so that the suspension rate of a product is influenced, and when the content is high, the crushed abamectin can still be rapidly aggregated into macromolecules to be deposited at the bottom of a suspension liquid, so that the pesticide application effect is influenced. The existing abamectin water dispersible granules have another defect that the duration of the drug effect is short after the application, and if the drug effect is lost due to rain erosion after the application, the drug effect is reduced or even ineffective.
Disclosure of Invention
The invention aims to solve the technical problems of low content of effective components, short duration and poor rain erosion resistance of the existing abamectin water dispersible granule.
In order to solve the technical problems, the technical scheme provided by the invention is as follows:
the high-content abamectin water dispersible granule comprises the following components in percentage by mass:
the abamectin water dispersible granule prepared by the invention has high content of effective components, has an obvious function of controlling slow release, can obviously prolong the lasting period of abamectin under the same dosage, reduces the using amount of pesticide, has excellent rain wash resistance and low loss rate, improves the utilization rate of the pesticide, and reduces the pollution of the pesticide to the environment.
Preferably, the abamectin water dispersible granule comprises the following components in percentage by mass: 40-60% of abamectin, 3.5-4.5% of wetting agent, 7.5-8.5% of dispersing agent, 3.5-4.5% of anti-decomposition embedding agent, 3.5-4.5% of cosolvent and the balance of filler.
The invention also provides a preparation method of the high-content abamectin water dispersible granule, which comprises the following steps:
step (a): weighing the components according to the design proportion of the abamectin water dispersible granule, uniformly mixing the weighed abamectin, wetting agent, anti-decomposition embedding agent, cosolvent and filler, and crushing by using an air flow crusher with the air pressure of 1-2 MPa to obtain ultrafine powder with the particle size of less than or equal to 10 microns;
step (b): dissolving the dispersing agent in ethanol, adding deionized water, stirring uniformly, adding into the superfine powder, mixing uniformly, granulating by a swinging granulator, drying for 20-40min at 50-70 ℃, and screening to obtain the abamectin water dispersible granule.
The preparation method has the advantages of no complex process, no need of special equipment, simple method, suitability for industrial production, simple formula, low auxiliary material cost and cost saving.
By selecting a proper formula and a proper preparation process, the abamectin dispersible granule provided by the invention has the advantages of short disintegration time, good suspension property and long lasting period.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
The high-content abamectin water dispersible granule comprises the following components in percentage by mass:
the abamectin water dispersible granule provided by the invention has the advantages of high content of effective components, short disintegration time, good suspension rate, rain wash resistance, long lasting period, low auxiliary material cost, simple processing and convenient use. Meanwhile, the water-based dosage form avoids the use of organic solvents, and has better environmental compatibility.
Preferably, the wetting agent is sodium diisopropyl naphthalene sulfonate which is very stable in acidic and alkaline environments and is a biodegradable green and environment-friendly product.
Preferably, the dispersing agent is alkylphenol polyoxyethylene ether phosphate ester, the alkylphenol polyoxyethylene ether phosphate ester is a comb-shaped polymer and has a large number of branched chains, and the branched chains can effectively prevent the pulverized abamectin ultrafine powder from aggregating into macromolecules.
Preferably, the anti-decomposition embedding agent is agar powder, the agar powder forms colloid embedding abamectin after meeting water, the agar melts at high temperature, the abamectin is slowly released, and the duration time of the pesticide effect is prolonged; the formed colloid can also prevent the problem of pesticide effect reduction caused by decomposition of abamectin after long-time exposure to ultraviolet light after pesticide application; the colloid formed by the agar powder in water also has stronger hydrophobicity, and can effectively prevent the rain from washing the medicine if meeting rainy weather after the medicine is applied.
Preferably, the cosolvent is povidone K30, the main active ingredient is 1-vinyl-2-pyrrolidone homopolymer, povidone K30 is selected as the cosolvent, the disintegration of the medicine cannot be delayed, and the solubility of the abamectin in water can be obviously improved after the solid povidone K30 is dissolved in the water, so that the suspension rate of the product is increased.
Preferably, the filler is one or more of starch, ammonium sulfate, lactose and white carbon black.
More preferably, the starch is corn starch, and the corn starch is low in price, stable in property and free of any pollution to the environment.
The prepared abamectin water dispersible granule has the advantages of short disintegration time, high suspension rate, high content of effective components, long duration and rain wash resistance due to the mutual synergy and comprehensive action of the components.
The embodiment of the invention also provides a preparation method of the high-content abamectin water dispersible granule, which comprises the following steps:
step (a): weighing the components according to the design proportion of the abamectin water dispersible granule, uniformly mixing the weighed abamectin, wetting agent, anti-decomposition embedding agent, cosolvent and filler, and crushing by using an air flow crusher with the air pressure of 1-2 MPa to obtain ultrafine powder with the particle size of less than or equal to 10 microns;
step (b): dissolving the dispersing agent in ethanol, adding deionized water, stirring uniformly, adding into the superfine powder, mixing uniformly, granulating by a swinging granulator, drying for 20-40min at 50-70 ℃, and screening to obtain the abamectin water dispersible granule.
Preferably, the adding amount of the ethanol in the step (b) is 5-8 wt% of the total amount of the weighed components, and the adding amount of the deionized water is 5-10 wt% of the total amount of the weighed components.
Compared with the existing common extrusion granulation, the swing granulation machine has the advantages of small swing granulation pressure, easy disintegration after drying, small water consumption, short product drying time and production energy consumption reduction.
In order to better illustrate the invention, the following examples are given by way of further illustration.
Example 1
The embodiment of the invention provides a high-content abamectin water dispersible granule, which comprises the following components in percentage by mass:
the preparation steps of the abamectin water dispersible granule are as follows:
weighing abamectin, sodium isopropyl naphthalene sulfonate, agar powder, polyvidone K30 and lactose according to the percentage content, uniformly stirring in a stirring kettle, crushing by a 1.5MPa air pressure jet mill, and uniformly mixing to obtain superfine powder with the particle size of less than or equal to 10 mu m;
dissolving alkylphenol polyoxyethylene ether phosphate with ethanol which accounts for 5 wt% of the total amount of all the materials, adding water which accounts for 10 wt% of the total amount of all the materials, uniformly stirring, uniformly mixing with the ultrafine powder, granulating by a swinging granulator, drying for half an hour at 60 ℃, and screening to obtain the abamectin water dispersible granule.
Example 2
The embodiment of the invention provides a high-content abamectin water dispersible granule, which comprises the following components in percentage by mass:
the preparation steps of the abamectin water dispersible granule are as follows:
weighing abamectin, sodium isopropyl naphthalene sulfonate, agar powder, polyvidone K30 and corn starch according to the percentage content, uniformly stirring in a stirring kettle, crushing by a 1.5MPa air pressure jet mill, and uniformly mixing to obtain superfine powder with the particle size of less than or equal to 10 mu m;
dissolving alkylphenol polyoxyethylene ether phosphate with ethanol with the weight of 6 wt% of the total amount of each material, adding water with the weight of 8 wt% of the total amount of each material, uniformly stirring, uniformly mixing with the ultrafine powder, granulating by a swinging granulator, drying for half an hour at 60 ℃, and screening to obtain the abamectin water dispersible granule.
Example 3
The embodiment of the invention provides a high-content abamectin water dispersible granule, which comprises the following components in percentage by mass:
the preparation steps of the abamectin water dispersible granule are as follows:
weighing abamectin, sodium isopropyl naphthalene sulfonate, agar powder, polyvidone K30 and ammonium sulfate according to the percentage content, uniformly stirring in a stirring kettle, crushing by a 2.0MPa air pressure jet mill, and uniformly mixing to obtain superfine powder with the particle size of less than or equal to 10 mu m;
dissolving alkylphenol polyoxyethylene ether phosphate with ethanol accounting for 8 wt% of the total amount of the materials, adding water accounting for 5 wt% of the total amount of the materials, uniformly stirring, uniformly mixing with the ultrafine powder, granulating by a swinging granulator, drying for half an hour at 60 ℃, and screening to obtain the abamectin water dispersible granule.
Comparative example 1
The difference from example 2 is that in this example, no decomposition-resistant embedding medium was added, and the contents of other components were the same as in example 2.
Weighing the following components in percentage by mass:
the preparation method of the abamectin water dispersible granule comprises the following steps:
weighing abamectin, sodium isopropyl naphthalene sulfonate, povidone K30 and corn starch as fillers according to the percentage content, uniformly stirring in a stirring kettle, crushing by a 1.5MPa air pressure jet mill, and uniformly mixing to obtain ultrafine powder;
dissolving alkylphenol polyoxyethylene ether phosphate with ethanol with the weight of 6 percent of the total weight of each material, adding water with the weight of 8 percent of the total weight of each material, uniformly stirring, uniformly mixing with the ultrafine powder, granulating by a swinging granulator, drying for half an hour at 60 ℃, and screening to obtain the abamectin water dispersible granule.
Comparative example 2
The proportions of the components are the same as in example 2, except that the swing granulation is changed into extrusion granulation in the preparation process. The preparation process comprises the following steps:
weighing abamectin, sodium isopropylnaphthalene sulfonate, agar powder, povidone K30 and corn starch according to the percentage ratio in the embodiment 2, uniformly stirring in a stirring kettle, crushing by a pneumatic jet mill with the air pressure of 1.5MPa, and uniformly mixing to obtain superfine powder;
dissolving alkylphenol polyoxyethylene ether phosphate with ethanol with the total amount of 8 wt% of the materials, adding water with the total amount of 12 wt% of the materials, uniformly stirring, uniformly mixing with the ultrafine powder, granulating by an extrusion granulator, drying for half an hour at 60 ℃, and screening to obtain the abamectin water dispersible granule.
The abamectin water dispersible granules prepared in the above examples 1-3 and comparative examples 1-2 were subjected to quality inspection, and the results are shown in table 1.
TABLE 1 quality index of Avermectin Water dispersible granule prepared in examples 1-3 and comparative examples 1-2
The abamectin water dispersible granules prepared in the examples 1 to 3 were subjected to a heat storage stability test, and the test results are shown in table 2.
The heat storage stability test conditions were: at 54 ℃ for 14 days
TABLE 2 results of the test of the thermal storage stability of the abamectin water dispersible granules prepared in examples 1 to 3
As can be seen from the results in tables 1 and 2, the abamectin water dispersion agent prepared in each example has short disintegration time, high content of effective components, high suspension rate and good heat storage stability.
In order to determine whether the product of the present invention has the effect of prolonging the duration, a field efficacy test was performed, and the test results are shown in table 3.
Test agents: the 50% abamectin water dispersible granule prepared in the example 2 and the 50% abamectin water dispersible granule prepared in the comparative example 1 without adding the anti-decomposition embedding medium.
The test conditions are as follows: test site: guangxi nanning; the concentration of the medicament: 5 g/mu, 3 g/mu and 1 g/mu; the rice leaf roller is a test pest;
in 2017, 4 months, 20 days to 5 months, 30 days, wherein 4 months, 22 days, 8 hours of light rain, 16 hours of medium rain in 23 days, and other times are mainly cloudy; the rainfall was about 60 hours in the 5 months, and cloudy weather in sunny days in other times.
The detection method comprises the following steps: calculating the prevention and treatment effect according to the poisoning rate and the death rate
The prevention efficiency is (number of poisoned insect population + number of dead insect population) ÷ total number of insect population
Effect of abamectin water dispersible granules with concentration of 350% in table on preventing and controlling rice leaf rollers
As can be seen from table 3: the abamectin water dispersible granule added with the anti-decomposition embedding agent still has higher control effect after being applied for 40 days; the abamectin water dispersible granule without the anti-decomposition embedding agent reaches the drug effect peak value when being applied for 2 to 3 days, and the drug effect is obviously reduced in the later period. The abamectin water dispersible granule added with the anti-decomposition embedding agent has the advantages that the pesticide effect is not obviously reduced when the using solubility is lower, but the lasting period is obviously prolonged, the purpose of reducing pesticide application and improving pesticide effect is achieved by the nation, and the social and economic benefits are higher.
In the experimental period, the weather is mostly rainy, the rainfall time is about 90 hours within 40 days of the pesticide application period, and the abamectin water dispersible granule added with the anti-decomposition embedding agent still has higher control effect after 40 days of pesticide application, which shows that the abamectin water dispersible granule prepared by the invention has the effect of rain erosion resistance.
In conclusion, the high-content abamectin water dispersible granule prepared by the invention is an efficient and slow-release green pesticide, has the advantages of high suspension rate, short disintegration time, long lasting period and good control effect, has the effect of rain erosion resistance, achieves the aim of lowering the application rate and improving the effect of the pesticide, and has higher social and economic benefits.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents or improvements made within the spirit and principle of the present invention should be included in the scope of the present invention.
Claims (6)
1. The high-content abamectin water dispersible granule is characterized by comprising the following components in percentage by mass:
wherein the dispersant is alkylphenol polyoxyethylene phosphate, and the anti-decomposition embedding agent is agar powder; the cosolvent is povidone K30.
2. The abamectin water dispersible granule according to claim 1, wherein the wetting agent is sodium diisopropyl naphthalene sulfonate.
3. The abamectin water dispersible granule according to claim 1, wherein the filler is one or more of starch, ammonium sulfate, lactose and white carbon black.
4. The abamectin water dispersible granule according to claim 3, wherein the starch is corn starch.
5. The abamectin water dispersible granule according to any one of claims 1 to 4, wherein the preparation method of the abamectin water dispersible granule comprises the following steps:
step (a): weighing the components according to the design proportion of the abamectin water dispersible granule, uniformly mixing the weighed abamectin, wetting agent, anti-decomposition embedding agent, cosolvent and filler, and crushing by using an air flow crusher with the air pressure of 1-2 MPa to obtain ultrafine powder with the particle size of less than or equal to 10 microns;
step (b): dissolving the dispersing agent in ethanol, adding deionized water, stirring uniformly, adding into the superfine powder, mixing uniformly, granulating by a swinging granulator, drying for 20-40min at 50-70 ℃, and screening to obtain the abamectin water dispersible granule.
6. The abamectin water dispersible granule according to claim 5, wherein the adding amount of the ethanol in the step (b) is 5-8 wt% of the total amount of the weighed components, and the adding amount of the deionized water is 5-10 wt% of the total amount of the weighed components.
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Non-Patent Citations (2)
| Title |
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| 50%阿维菌素水分散粒剂的研究;王同涛 等;《精细与专用化学品》;20051006;第13卷(第19期);第18-20页 * |
| 阿维菌素B2海藻酸钠-壳聚糖包埋颗粒剂的制备及性能研究;王召 等;《农药学学报》;20171215;第19卷(第6期);第744-754页 * |
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