CN108402036A - A kind of pharmaceutical preparation and its preparation process of prevention acarid - Google Patents
A kind of pharmaceutical preparation and its preparation process of prevention acarid Download PDFInfo
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- CN108402036A CN108402036A CN201810121647.8A CN201810121647A CN108402036A CN 108402036 A CN108402036 A CN 108402036A CN 201810121647 A CN201810121647 A CN 201810121647A CN 108402036 A CN108402036 A CN 108402036A
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/08—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing solids as carriers or diluents
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/22—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing ingredients stabilising the active ingredients
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/02—Saturated carboxylic acids or thio analogues thereof; Derivatives thereof
- A01N37/04—Saturated carboxylic acids or thio analogues thereof; Derivatives thereof polybasic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/26—Phosphorus; Compounds thereof
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- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Dentistry (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Toxicology (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention relates to technical field of pest control, and in particular to a kind of pharmaceutical preparation of prevention acarid, the pharmaceutical preparation include：Binary acid dialkyl, zeolite, aluminum phosphate, methylcellulose, calcium stearate, dimethylbenzene, white oil.The preparation method of the pharmaceutical preparation includes the following steps：（1）Zeolite is put into dimethylbenzene and is stirred, centrifuges, dry；（2）Methylcellulose is configured to 6% solution, then the zeolite input after above-mentioned drying process is wherein stirred, centrifuges, dry；（3）It crushes, is sieved after binary acid dialkyl, aluminum phosphate, calcium stearate are mixed；（4）Add white oil to be added in dispersion machine the material after pulverizing and sieving to be uniformly mixed；（5）Add zeolite to be placed in mixing machine the material after dispersion to be uniformly mixed.The present invention is controlled by screening to raw material and dosage, and drive acarid effect, stability and the slow release of obtained pharmaceutical preparation significantly improve, and show excellent drive acarid.
Description
Technical field
The present invention relates to technical field of pest control, and in particular to a kind of pharmaceutical preparation and its preparation work of prevention acarid
Skill.
Background technology
Nowadays, by harmful organism, the especially disease of the propagation such as bite pest such as acarid class, from the point of view of world wide
There are many quantity, and from the point of view of Distribution Breadth, illness rate, lethality etc., it is believed that are dangerous high diseases.Therefore having must
A kind of pharmaceutical preparation of prevention acarid is provided.
It is miscellaneous for as the mite of pest there is the medicament of anthelminthic effect to have, such as application No. is
The patent of CN201210356762.6 discloses a kind of anti-mite finishing agent, the anti-mite method for sorting of fabric and anti-mite and knits
Object, it is safe and effective, fabric made from final finishing is impregnated or padded using anti-mite finishing agent of the present invention, is had to acarid good
Walk quickly and keep away performance, and fabric and skin surface Long Term Contact, it is safe and non-stimulating the advantages that.Applicant have discovered that the anti-mite is whole
Manage agent it is volatile or it is heated it is easy decomposition and anthelminthic effect decline the problem of.
For another example application No. is the patents of CN200710055353.1 to disclose a kind of external application for treating disease caused by acarids
Pharmaceutical preparation, it is convenient, applied widely and without any side effects with good effect, medication, still, the slow release of pharmaceutical
Property is relatively poor, and the duration of drug effect is short.
Therefore select the weight percent of suitable raw material and each constituent of control compare pharmaceutical preparation drive acarid effect,
Stability and slow release are vital.
The present invention is controlled, obtained pharmaceutical preparation by screening to raw material and dosage by a large amount of experimental study
Drive acarid effect, stability and slow release significantly improve, the binary acid dialkyl used can effectively inhibit the life of acarid
Long breeding, until killing acarid, and makes binary acid dialkyl enter in the pore of zeolite by the cooperation with porous zeolite,
So that become larger to the medicament ratio of the useful effect of acarid, to have preferable drive acarid effect, meanwhile, it ensure that medicine
The slow release of object preparation, low is released from inorganic porous zeolite and it drives acarid lasts, existing to overcome
In technology prevent acarid pharmaceutical preparation there are the problem of.
Invention content
In view of this, the present invention provides a kind of pharmaceutical preparation of prevention acarid, have drive acarid effect is good, stability is strong,
The advantages of had good sustained release effect, shows excellent drive acarid.
In order to achieve the above object, the present invention is achieved through the following technical solutions：
A kind of pharmaceutical preparation of prevention acarid, the pharmaceutical preparation include：Binary acid dialkyl, zeolite, basic zirconium phosphate, Methyl cellulose
Element, stearic acid aluminium, dimethylbenzene, white oil.
Preferably, in terms of parts by weight, the pharmaceutical preparation includes：25-30 parts of binary acid dialkyl, zeolite 30-35
Part, 22-26 parts of basic zirconium phosphate, 7-9 parts of methylcellulose, 0.1-0.3 parts of stearic acid aluminium, 7-9 parts of dimethylbenzene, 0.2-0.4 parts of white oil.
Preferably, in terms of parts by weight, the pharmaceutical preparation includes：27 parts of binary acid dialkyl, 32.5 parts of zeolite, phosphorus
24 parts of sour zirconium, 8 parts of methylcellulose, 0.2 part of stearic acid aluminium, 8 parts of dimethylbenzene, 0.3 part of white oil.
Preferably, the BET specific surface area of the zeolite is 550-900m2/ g and fine pore are 0.8-15nm.
The present invention also provides a kind of preparation processes of the pharmaceutical preparation of prevention acarid, include the following steps：
（1）Zeolite is put into dimethylbenzene and is stirred, is subsequently placed in centrifuge and realizes that zeolite is detached with dimethylbenzene, finally
It is dried after zeolite is handled with clear water；
（2）Methylcellulose is configured to 4% solution, is then wherein stirred the zeolite input after above-mentioned drying process,
Then it carries out centrifugal treating and realizes that zeolite is detached with methocel solution, processing is finally dried；
（3）It crushes, is sieved after binary acid dialkyl, basic zirconium phosphate, stearic acid aluminium are mixed；
（4）Add white oil to be added in dispersion machine the material after pulverizing and sieving to be uniformly mixed；
（5）Add zeolite to be placed in mixing machine the material after dispersion to be uniformly mixed, obtain mixture, then heat the mixture
It is dry, obtain the pharmaceutical preparation of the prevention acarid.
Preferably, step（1）Described in centrifuge carry out centrifugal treating condition：Rotating speed is controlled in 2500-
3000r/min, centrifugal treating time 4-6min.
Preferably, step（2）The condition of middle centrifugal treating：Rotating speed 4000-5000r/min, centrifugal treating time 12-
14min。
Preferably, step（3）In sieving be sieve with 100 mesh sieve.
Preferably, step（4）The speed control of middle dispersion machine disperses 15-18min in 600-700r/min.
Preferably, step（5）In heat drying condition：The dry 60-70min at 80-90 DEG C.
Compared with prior art, the present invention having following advantageous effect：
（1）The present invention is controlled by screening to raw material and dosage, the drive acarid effect of obtained pharmaceutical preparation, stability and
Slow release significantly improves, and shows excellent drive acarid.
（2）Binary acid dialkyl can effectively inhibit the growth and breeding of acarid, until kill acarid, and by with it is more
The cooperation of the zeolite in hole makes binary acid dialkyl enter in the pore of zeolite, so that the medicament of the useful effect to acarid
Ratio becomes larger, to have preferable drive acarid effect, meanwhile, the slow release of pharmaceutical preparation is ensure that, from inorganic porous boiling
It low is released in stone and it drives acarid lasts.
（3）Before binary acid dialkyl is combined with zeolite, first passes through dimethylbenzene and the pore of zeolite surface and surface is cleared up,
The impurity in zeolite surface and surface pores is cleaned up, is then mixed again with zeolite by being used as the methylcellulose of binder
It closes so that adhere to methylcellulose in the pore on zeolite surface and surface, to increase medicament and zeolite bonding force, in turn
The stability for increasing pharmaceutical preparation, then carries out centrifugal treating again so that zeolite surface and the upper Methyl cellulose of surface pores attachment
Element, which adds binary acid dialkyls and zeolite binding force, and which prevent binary acid dialkyls to fall off, and influence to drive acarid
Effect, to increase the stability of pharmaceutical preparation.
（4）The basic zirconium phosphate of the present invention has stronger acidity, can further enhance the effect of the drive acarid of the pharmaceutical preparation.
（5）The thermal stability of the pharmaceutical preparation can be improved in the stearic acid aluminium of the present invention, and white oil improves the effect of mixing dispersion
Fruit, to improve the stability of pharmaceutical preparation and drive acarid.
Specific implementation mode
Form by the following examples is described in further detail the above of the present invention again, but should not be by this
The range for being interpreted as the above-mentioned theme of the present invention is only limitted to following embodiment, all based on the technology realized belonging to the above of the present invention
It all belongs to the scope of the present invention.
Embodiment 1
A kind of pharmaceutical preparation of prevention acarid, the pharmaceutical preparation include：Binary acid dialkyl, zeolite, basic zirconium phosphate, Methyl cellulose
Element, stearic acid aluminium, dimethylbenzene, white oil.
Wherein, in terms of parts by weight, the pharmaceutical preparation includes：27 parts of binary acid dialkyl, 32.5 parts of zeolite, basic zirconium phosphate
24 parts, 8 parts of methylcellulose, 0.2 part of stearic acid aluminium, 8 parts of dimethylbenzene, 0.3 part of white oil.
Wherein, the BET specific surface area of the zeolite is 730m2/ g and fine pore are 1.2nm.
The present invention also provides a kind of preparation processes of the pharmaceutical preparation of prevention acarid, include the following steps：
（1）Zeolite is put into dimethylbenzene and is stirred, is subsequently placed in centrifuge and realizes that zeolite is detached with dimethylbenzene, finally
It is dried after zeolite is handled with clear water；
（2）Methylcellulose is configured to 4% solution, is then wherein stirred the zeolite input after above-mentioned drying process,
Then it carries out centrifugal treating and realizes that zeolite is detached with methocel solution, processing is finally dried；
（3）It crushes, is sieved after binary acid dialkyl, basic zirconium phosphate, stearic acid aluminium are mixed；
（4）Add white oil to be added in dispersion machine the material after pulverizing and sieving to be uniformly mixed；
（5）Add zeolite to be placed in mixing machine the material after dispersion to be uniformly mixed, obtain mixture, then heat the mixture
It is dry, obtain the pharmaceutical preparation of the prevention acarid.
Wherein, step（1）Described in centrifuge carry out centrifugal treating condition：Rotating speed is controlled in 2750r/min, centrifugation
Processing time 5min.
Wherein, step（2）The condition of middle centrifugal treating：Rotating speed 4500r/min, centrifugal treating time 13min.
Wherein, step（3）In sieving be sieve with 100 mesh sieve.
Wherein, step（4）The speed control of middle dispersion machine disperses 16.5min in 650r/min.
Wherein, step（5）In heat drying condition：The dry 65min at 85 DEG C.
Embodiment 2
A kind of pharmaceutical preparation of prevention acarid, the pharmaceutical preparation include：Binary acid dialkyl, zeolite, basic zirconium phosphate, Methyl cellulose
Element, stearic acid aluminium, dimethylbenzene, white oil.
Wherein, in terms of parts by weight, the pharmaceutical preparation includes：25 parts of binary acid dialkyl, 30 parts of zeolite, basic zirconium phosphate 22
Part, 7 parts of methylcellulose, 0.1 part of stearic acid aluminium, 7 parts of dimethylbenzene, 0.2 part of white oil.
Wherein, the BET specific surface area of the zeolite is 550m2/ g and fine pore are 0.8nm.
The present invention also provides a kind of preparation processes of the pharmaceutical preparation of prevention acarid, include the following steps：
（1）Zeolite is put into dimethylbenzene and is stirred, is subsequently placed in centrifuge and realizes that zeolite is detached with dimethylbenzene, finally
It is dried after zeolite is handled with clear water；
（2）Methylcellulose is configured to 4% solution, is then wherein stirred the zeolite input after above-mentioned drying process,
Then it carries out centrifugal treating and realizes that zeolite is detached with methocel solution, processing is finally dried；
（3）It crushes, is sieved after binary acid dialkyl, basic zirconium phosphate, stearic acid aluminium are mixed；
（4）Add white oil to be added in dispersion machine the material after pulverizing and sieving to be uniformly mixed；
（5）Add zeolite to be placed in mixing machine the material after dispersion to be uniformly mixed, obtain mixture, then heat the mixture
It is dry, obtain the pharmaceutical preparation of the prevention acarid.
Wherein, step（1）Described in centrifuge carry out centrifugal treating condition：Rotating speed is controlled in 2500r/min, centrifugation
Processing time 4min.
Wherein, step（2）The condition of middle centrifugal treating：Rotating speed 4000r/min, centrifugal treating time 12min.
Wherein, step（3）In sieving be sieve with 100 mesh sieve.
Wherein, step（4）The speed control of middle dispersion machine disperses 15min in 600r/min.
Wherein, step（5）In heat drying condition：The dry 60min at 80 DEG C.
Embodiment 3
A kind of pharmaceutical preparation of prevention acarid, the pharmaceutical preparation include：Binary acid dialkyl, zeolite, basic zirconium phosphate, Methyl cellulose
Element, stearic acid aluminium, dimethylbenzene, white oil.
Wherein, in terms of parts by weight, the pharmaceutical preparation includes：30 parts of binary acid dialkyl, 35 parts of zeolite, basic zirconium phosphate 26
Part, 9 parts of methylcellulose, 0.3 part of stearic acid aluminium, 9 parts of dimethylbenzene, 0.4 part of white oil.
Wherein, the BET specific surface area of the zeolite is 900m2/ g and fine pore are 15nm.
The present invention also provides a kind of preparation processes of the pharmaceutical preparation of prevention acarid, include the following steps：
（1）Zeolite is put into dimethylbenzene and is stirred, is subsequently placed in centrifuge and realizes that zeolite is detached with dimethylbenzene, finally
It is dried after zeolite is handled with clear water；
（2）Methylcellulose is configured to 4% solution, is then wherein stirred the zeolite input after above-mentioned drying process,
Then it carries out centrifugal treating and realizes that zeolite is detached with methocel solution, processing is finally dried；
（3）It crushes, is sieved after binary acid dialkyl, basic zirconium phosphate, stearic acid aluminium are mixed；
（4）Add white oil to be added in dispersion machine the material after pulverizing and sieving to be uniformly mixed；
（5）Add zeolite to be placed in mixing machine the material after dispersion to be uniformly mixed, obtain mixture, then heat the mixture
It is dry, obtain the pharmaceutical preparation of the prevention acarid.
Wherein, step（1）Described in centrifuge carry out centrifugal treating condition：Rotating speed is controlled in 3000r/min, centrifugation
Processing time 6min.
Wherein, step（2）The condition of middle centrifugal treating：Rotating speed 5000r/min, centrifugal treating time 14min.
Wherein, step（3）In sieving be sieve with 100 mesh sieve.
Wherein, step（4）The speed control of middle dispersion machine disperses 18min in 700r/min.
Wherein, step（5）In heat drying condition：The dry 70min at 90 DEG C.
Comparative example 1
A kind of pharmaceutical preparation of prevention acarid, it is essentially identical with the method for embodiment 1, the difference is that：
A kind of pharmaceutical preparation of prevention acarid, the pharmaceutical preparation include：Binary acid dialkyl, zeolite, basic zirconium phosphate, Methyl cellulose
Element, stearic acid aluminium, white oil.
Wherein, when with weight percent, the pharmaceutical preparation includes：30 parts of binary acid dialkyl, 35.5 parts of zeolite, phosphoric acid
25 parts of aluminium, 3.2 parts of methylcellulose, 3.5 parts of calcium stearate, 1.8 parts of white oil.
A kind of preparation method of the pharmaceutical preparation of prevention acarid, includes the following steps：
（1）Methylcellulose is configured to 4% solution, is then wherein stirred the zeolite input after above-mentioned drying process,
Then it carries out centrifugal treating and realizes that zeolite is detached with methocel solution, processing is finally dried；
（2）It crushes, is sieved after binary acid dialkyl, basic zirconium phosphate, stearic acid aluminium are mixed；
（3）Add white oil to be added in dispersion machine the material after pulverizing and sieving to be uniformly mixed；
（4）Add zeolite to be placed in mixing machine the material after dispersion to be uniformly mixed, obtain mixture, then heat the mixture
It is dry, obtain the pharmaceutical preparation of the prevention acarid.
Comparative example 2
A kind of pharmaceutical preparation of prevention acarid, it is essentially identical with the method for embodiment 1, the difference is that：
A kind of pharmaceutical preparation of prevention acarid, the pharmaceutical preparation include：Binary acid dialkyl, zeolite, basic zirconium phosphate, stearic acid
Aluminium, dimethylbenzene.
With weight percentage, the pharmaceutical preparation includes：27 parts of binary acid dialkyl, 32.5 parts of zeolite, 22 parts of basic zirconium phosphate,
0.5 part of stearic acid aluminium, 15 parts of dimethylbenzene, 0.6 part of white oil.
A kind of preparation method of the pharmaceutical preparation of prevention acarid, includes the following steps：
（1）Zeolite is put into dimethylbenzene and is stirred, is subsequently placed in centrifuge and realizes that zeolite is detached with dimethylbenzene, finally
It is dried after zeolite is handled with clear water；
（2）It crushes, is sieved after binary acid dialkyl, basic zirconium phosphate, stearic acid aluminium are mixed；
（3）Add white oil to be added in dispersion machine the material after pulverizing and sieving to be uniformly mixed；
（4）Add zeolite to be placed in mixing machine the material after dispersion to be uniformly mixed, obtain mixture, then heat the mixture
It is dry, obtain the pharmaceutical preparation of the prevention acarid.
Experimental example 1
Zeolite surface in the pharmaceutical preparation prepared below to above-described embodiment 1-3 pharmaceutical preparations prepared and comparative example 1-2 is negative
The pharmaceutical quantities of load are detected, and specific experiment result is as follows：
1 the performance test results of table
As shown in Table 1, comparative example 1, the medicament load capacity of comparative example 2 are respectively less than embodiment 1-3, illustrate by dimethylbenzene, methyl
The medicament load capacity of cellulose treated zeolite is significantly larger than without by dimethylbenzene, methylcellulose treated zeolite,
Meanwhile the medicament that be better than dimethylbenzene treated zeolite by the medicament load capacity of methylcellulose treated zeolite is negative
Carrying capacity.
Experimental example 2
The duration of disinsectization performance：
Specific test method：The cellulose plate of long 110mm × wide 110mm × thickness 1mm is made, uniformly smears upper drug system thereon
Agent, and according to FZ/T 01100-2008《The evaluation of the anti-mite performance of textile》, come judge pharmaceutical preparation expelling parasite duration.
2 the performance test results of table
| Project | Exposure duration（It） | Walk quickly and keep away rate（%） | Exposure duration（It） | Walk quickly and keep away rate（%） | Exposure duration（It） | Walk quickly and keep away rate（%） |
| Embodiment 1 | 5 | 95.5 | 10 | 95.2 | 15 | 93.4 |
| Embodiment 2 | 5 | 93.5 | 10 | 91.2 | 15 | 89.5 |
| Embodiment 3 | 5 | 94.8 | 10 | 92.8 | 15 | 90.7 |
| Comparative example 1 | 5 | 82.5 | 10 | 65.3 | 15 | 48.3 |
| Comparative example 2 | 5 | 75.2 | 10 | 55.2 | 15 | 37.8 |
As shown in Table 2, the expelling parasite duration that the pharmaceutical preparation of inorganic porous substance zeolite is added is significantly larger than inorganic without being added
Porous pharmaceutical preparation, it follows that by by the drug loading of expelling parasite on inorganic porous substance so that drug system obtained
Agent has the slow release of appropriateness, that is, increases the duration of the expelling parasite of pharmaceutical preparation.
It is merely a preferred embodiment of the present invention, is not intended to restrict the invention, although with reference to aforementioned implementation described in upper
Invention is explained in detail for example, for those skilled in the art, still can be to foregoing embodiments
Recorded technical solution is modified or equivalent replacement of some of the technical features.All spirit in the present invention
Within principle, any modification, equivalent replacement, improvement and so on should all be included in the protection scope of the present invention.
Claims (10)
1. a kind of pharmaceutical preparation of prevention acarid, which is characterized in that the pharmaceutical preparation includes：Binary acid dialkyl, zeolite, phosphorus
Sour zirconium, methylcellulose, stearic acid aluminium, dimethylbenzene, white oil.
2. the pharmaceutical preparation of prevention acarid according to claim 1, which is characterized in that in terms of parts by weight, the drug
Preparation includes：25-30 parts of binary acid dialkyl, 30-35 parts of zeolite, 22-26 parts of basic zirconium phosphate, 7-9 parts of methylcellulose, stearic acid
0.1-0.3 parts of aluminium, 7-9 parts of dimethylbenzene, 0.2-0.4 parts of white oil.
3. the pharmaceutical preparation of prevention acarid according to claim 2, which is characterized in that in terms of parts by weight, the drug
Preparation includes：27 parts of binary acid dialkyl, 32.5 parts of zeolite, 24 parts of basic zirconium phosphate, 8 parts of methylcellulose, 0.2 part of stearic acid aluminium,
8 parts of dimethylbenzene, 0.3 part of white oil.
4. the pharmaceutical preparation of prevention acarid according to claim 1, which is characterized in that the BET specific surface area of the zeolite
For 550-900m2/ g and fine pore are 0.8-15nm.
5. a kind of preparation process of the pharmaceutical preparation of prevention acarid, which is characterized in that include the following steps：
（1）Zeolite is put into dimethylbenzene and is stirred, is subsequently placed in centrifuge and realizes that zeolite is detached with dimethylbenzene, finally
It is dried after zeolite is handled with clear water；
（2）Methylcellulose is configured to 4% solution, is then wherein stirred the zeolite input after above-mentioned drying process,
Then it carries out centrifugal treating and realizes that zeolite is detached with methocel solution, processing is finally dried；
（3）It crushes, is sieved after binary acid dialkyl, basic zirconium phosphate, stearic acid aluminium are mixed；
（4）Add white oil to be added in dispersion machine the material after pulverizing and sieving to be uniformly mixed；
（5）Add zeolite to be placed in mixing machine the material after dispersion to be uniformly mixed, obtain mixture, then heat the mixture
It is dry, obtain the pharmaceutical preparation of the prevention acarid.
6. the preparation process of the pharmaceutical preparation of prevention acarid according to claim 5, which is characterized in that step（1）Middle institute
The centrifuge stated carries out the condition of centrifugal treating：Rotating speed is controlled in 2500-3000r/min, centrifugal treating time 4-6min.
7. the preparation process of the pharmaceutical preparation of prevention acarid according to claim 5, which is characterized in that step（2）In from
The condition of heart processing：Rotating speed 4000-5000r/min, centrifugal treating time 12-14min.
8. the preparation process of the pharmaceutical preparation of prevention acarid according to claim 5, which is characterized in that step（3）In
Sieving is to sieve with 100 mesh sieve.
9. the preparation process of the pharmaceutical preparation of prevention acarid according to claim 5, which is characterized in that step（4）In point
The speed control of machine is dissipated in 600-700r/min, disperses 15-18min.
10. the preparation process of the pharmaceutical preparation of prevention acarid according to claim 5, which is characterized in that step（5）In
The condition of heat drying：The dry 60-70min at 80-90 DEG C.
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| CN106455559A (en) * | 2014-06-19 | 2017-02-22 | 东亚合成株式会社 | Mite repellent, and mite-repellent resin composition and mite-repellent product using same |
| CN106365840A (en) * | 2016-08-30 | 2017-02-01 | 广东省生物工程研究所（广州甘蔗糖业研究所） | Ecological regulation agent and preparation method and application thereof |
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