CN109673736A - A kind of preparation method of ellagic acid-PVP food fresh keeping solid dispersions - Google Patents
A kind of preparation method of ellagic acid-PVP food fresh keeping solid dispersions Download PDFInfo
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- CN109673736A CN109673736A CN201910064270.1A CN201910064270A CN109673736A CN 109673736 A CN109673736 A CN 109673736A CN 201910064270 A CN201910064270 A CN 201910064270A CN 109673736 A CN109673736 A CN 109673736A
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- Prior art keywords
- ellagic acid
- pvp
- solid dispersions
- preparation
- fresh keeping
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- 239000007962 solid dispersion Substances 0.000 title claims abstract description 34
- 235000013305 food Nutrition 0.000 title claims abstract description 14
- 238000002360 preparation method Methods 0.000 title claims abstract description 11
- AFSDNFLWKVMVRB-UHFFFAOYSA-N Ellagic acid Chemical compound OC1=C(O)C(OC2=O)=C3C4=C2C=C(O)C(O)=C4OC(=O)C3=C1 AFSDNFLWKVMVRB-UHFFFAOYSA-N 0.000 claims abstract description 42
- ATJXMQHAMYVHRX-CPCISQLKSA-N Ellagic acid Natural products OC1=C(O)[C@H]2OC(=O)c3cc(O)c(O)c4OC(=O)C(=C1)[C@H]2c34 ATJXMQHAMYVHRX-CPCISQLKSA-N 0.000 claims abstract description 42
- 229920002079 Ellagic acid Polymers 0.000 claims abstract description 42
- 235000004132 ellagic acid Nutrition 0.000 claims abstract description 42
- 229960002852 ellagic acid Drugs 0.000 claims abstract description 42
- FAARLWTXUUQFSN-UHFFFAOYSA-N methylellagic acid Natural products O1C(=O)C2=CC(O)=C(O)C3=C2C2=C1C(OC)=C(O)C=C2C(=O)O3 FAARLWTXUUQFSN-UHFFFAOYSA-N 0.000 claims abstract description 42
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 17
- 238000002390 rotary evaporation Methods 0.000 claims abstract description 7
- 238000009210 therapy by ultrasound Methods 0.000 claims abstract description 5
- 239000007787 solid Substances 0.000 claims description 10
- 229960000935 dehydrated alcohol Drugs 0.000 claims description 6
- 229960004756 ethanol Drugs 0.000 claims description 4
- 239000004570 mortar (masonry) Substances 0.000 claims description 4
- 239000000843 powder Substances 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 2
- 238000004321 preservation Methods 0.000 abstract description 10
- 239000013078 crystal Substances 0.000 abstract description 8
- 238000012545 processing Methods 0.000 abstract description 4
- 229920000036 polyvinylpyrrolidone Polymers 0.000 abstract 7
- 239000001267 polyvinylpyrrolidone Substances 0.000 abstract 4
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 abstract 4
- 238000009825 accumulation Methods 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 230000006641 stabilisation Effects 0.000 abstract 1
- 238000011105 stabilization Methods 0.000 abstract 1
- 238000002525 ultrasonication Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 238000004220 aggregation Methods 0.000 description 3
- 230000002776 aggregation Effects 0.000 description 3
- 230000003078 antioxidant effect Effects 0.000 description 3
- 238000001878 scanning electron micrograph Methods 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- 238000004566 IR spectroscopy Methods 0.000 description 2
- 239000011149 active material Substances 0.000 description 2
- 239000003963 antioxidant agent Substances 0.000 description 2
- 235000006708 antioxidants Nutrition 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000002211 ultraviolet spectrum Methods 0.000 description 2
- 241000251468 Actinopterygii Species 0.000 description 1
- 235000011201 Ginkgo Nutrition 0.000 description 1
- 244000194101 Ginkgo biloba Species 0.000 description 1
- 235000008100 Ginkgo biloba Nutrition 0.000 description 1
- 241000725303 Human immunodeficiency virus Species 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 241001596950 Larimichthys crocea Species 0.000 description 1
- 241000899834 Obovaria olivaria Species 0.000 description 1
- 244000294611 Punica granatum Species 0.000 description 1
- 235000014360 Punica granatum Nutrition 0.000 description 1
- 240000007651 Rubus glaucus Species 0.000 description 1
- 235000011034 Rubus glaucus Nutrition 0.000 description 1
- 235000009122 Rubus idaeus Nutrition 0.000 description 1
- 241001125843 Trichiuridae Species 0.000 description 1
- 240000000851 Vaccinium corymbosum Species 0.000 description 1
- 235000003095 Vaccinium corymbosum Nutrition 0.000 description 1
- 235000017537 Vaccinium myrtillus Nutrition 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 235000009754 Vitis X bourquina Nutrition 0.000 description 1
- 235000012333 Vitis X labruscana Nutrition 0.000 description 1
- 240000006365 Vitis vinifera Species 0.000 description 1
- 235000014787 Vitis vinifera Nutrition 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 235000021014 blueberries Nutrition 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000000975 co-precipitation Methods 0.000 description 1
- 238000004320 controlled atmosphere Methods 0.000 description 1
- 238000006471 dimerization reaction Methods 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000009920 food preservation Methods 0.000 description 1
- 239000005452 food preservative Substances 0.000 description 1
- 235000019249 food preservative Nutrition 0.000 description 1
- LNTHITQWFMADLM-UHFFFAOYSA-N gallic acid Chemical class OC(=O)C1=CC(O)=C(O)C(O)=C1 LNTHITQWFMADLM-UHFFFAOYSA-N 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 239000012052 hydrophilic carrier Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000009878 intermolecular interaction Effects 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000013011 mating Effects 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 231100000404 nontoxic agent Toxicity 0.000 description 1
- 230000000505 pernicious effect Effects 0.000 description 1
- 150000008442 polyphenolic compounds Chemical class 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000005057 refrigeration Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23B—PRESERVING, e.g. BY CANNING, MEAT, FISH, EGGS, FRUIT, VEGETABLES, EDIBLE SEEDS; CHEMICAL RIPENING OF FRUIT OR VEGETABLES; THE PRESERVED, RIPENED, OR CANNED PRODUCTS
- A23B4/00—General methods for preserving meat, sausages, fish or fish products
- A23B4/14—Preserving with chemicals not covered by groups A23B4/02 or A23B4/12
- A23B4/18—Preserving with chemicals not covered by groups A23B4/02 or A23B4/12 in the form of liquids or solids
- A23B4/20—Organic compounds; Microorganisms; Enzymes
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
Abstract
The invention discloses a kind of preparation methods of ellagic acid-PVP food fresh keeping solid dispersions, polyvinylpyrrolidone (PVP) is under hot ethanol dissolved state, molecule crimps chain and opens, ellagic acid in the curling chain of grain refinement and entrance PVP, carries out rotary evaporation processing removal solvent again and obtains ellagic acid-PVP solid dispersions under ultrasonication after ultrasonic treatment.The property that ellagic acid-PVP solid dispersions retain ellagic acid prevents the crystal accumulation of ellagic acid to grow up while stabilization, improves the solubility of ellagic acid, has broad application prospects on preservation of fishery.The PVP of different average molecular weight has different caking property, may be used to prepare solid dispersions.
Description
Technical field
The present invention relates to a kind of safety suitable for preservation of fishery, effective ellagic acid-PVP food fresh keeping solids point
The preparation method of granular media, the ellagic acid-PVP solid dispersions being prepared can be used for the fresh-keeping of fish.
Background technique
Preservation of fishery is exactly that the means such as Applied Physics, chemistry and biology handle it, to keep or protect as far as possible
Hold its original freshness.Currently, being applied to the preservation technology of aquatic products has low temperature, chemistry, irradiation, controlled atmosphere and biological preservation
Deng.Wherein, the most universal using antistaling agent and low in cost, it is easy to spread.In recent years, with the raising of people's environmental consciousness
With the development of preservation technology, the safety of fresh chemically gradually causes the worry of people, some biological preservations with Nantural non-toxic
Agent is common concern of the Preservation Treatment technology of raw material progress by people, and starts processing, the storage, fortune applied to aquatic products
In defeated and process of consumption.
Ellagic acid is the dimerization derivative of gallic acid, is a kind of polyphenol dilactone, ellagic acid content in raw-food material
Abundant, the content in the nuts such as the mushy fruits such as raspberry, blueberry and ginkgo, hickory nut is all very high, meanwhile, in the inedible of food
In part, the content such as ellagic acid in granatum, pomegranate seed, grape pip is also very high, the content of ellagic acid in granatum hydrolyzate
It is 12%.Ellagic acid can inhibit " pernicious " hormone secretion related with type II diabetes, and human immunodeficiency virus is inhibited to inhale
Attached, its antioxidant activity is 50 times of vitamin E, but the crystal structure of ellagic acid keeps its solubility in water very low,
Only 0.026mg/ml, the bioavilability that low solubility directly results in ellagic acid is low, and inoxidizability is difficult to play.
Solid dispersions refer to a kind of solid shape for dispersing hydrophilic carrier matrix for the substance of poorly water-soluble and being formed
The decentralized system of formula, the release conditions of active material are determined by polymer in decentralized system.Under dissolved state, polymer molecule
Chain expansion, active material enter the dispersion of formation molecular level in the curling chain of carrier, and intermolecular interaction generates hydrogen
Key or mating reaction inhibitory activity substance nucleus generate and growth is to achieve the purpose that improve solubility.Solid dispersions have
The advantages of production method is simply various, low manufacture cost.
Summary of the invention
It is an object of the invention to strong ellagic acid inoxidizability aiming at the problem that poorly water-soluble, a kind of ellagic acid-is proposed
The preparation method of PVP solid dispersions food preservative inhibits the aggregation and growth of ellagic acid crystal, makes ellagic acid in aqueous solution
In be easier to scatter, increase the solubility of ellagic acid, expand application of the ellagic acid as antistaling agent in food, especially exist
Application in the high aquatic products of surface moisture content, pushes the development of field of food preservation.
The purpose of the present invention is achieved through the following technical solutions: a kind of ellagic acid-PVP food fresh keeping solid dispersion
The preparation method of body, includes the following steps:
(1) by mass ratio be 1:(3~5) ellagic acid and PVP be completely dissolved in 60 DEG C of dehydrated alcohol；
(2) ultrasound treatment step (1) 0.5~1h of acquired solution；
(3) rotary evaporation removes vehicle of ethanol, scrapes the solid of revolving bottle inner wall, is put into baking oven and balances drying；
(4) pale yellow powder obtained is ellagic acid-PVP solid dispersions.
Further, ellagic acid is first crossed into 80~100 meshes before being dissolved in 60 DEG C of dehydrated alcohol in the step (1).
Further, in the step (3), the revolving speed of the rotary evaporation is 50~80r/min, and temperature is 50~70
Degree.
Further, balancing the dry time is 8~12h.
Further, balance is dry uses mortar milled solids, after 80~100 meshes.
Compared with prior art, the beneficial effects of the present invention are: the present invention uses water-solubility carrier PVP in conjunction with ellagic acid
The method for preparing solid dispersions prevents the aggregation and growth of ellagic acid crystal, remains the inoxidizability of ellagic acid, improve
The water solubility of ellagic acid can rest on food surface for more time, can effectively extend Food Shelf-life, suitable for aquatic products
Preservation Treatment.
Detailed description of the invention
Figure 1A is that the SEM of ellagic acid crystal schemes；Figure 1B is the ellagic acid-PVP solid dispersions that embodiment 1 is prepared
SEM figure.
Specific embodiment mode
Present invention will be further explained below with reference to specific examples.
Embodiment 1:
1, ellagic acid crosses 80 mesh 3-5 times, accurately weighs 1g ellagic acid and 3g PVPk30, it is completely dissolved under stirring
The hot dehydrated alcohol of 80mL60 DEG C of water bath processing.
2, ultrasound treatment step (1) acquired solution 0.5h.
3, rotary evaporation removes vehicle of ethanol, scrapes the solid of revolving bottle inner wall, is put into baking oven and balances dry 12h.
4,80 meshes are crossed after mortar milled solids, obtained pale yellow powder is ellagic acid-PVP solid dispersions, dry
It saves.
Ellagic acid therein can be extracted from granatum.
Identify that ellagic acid and PVP are complexed successfully through infrared spectroscopy, ultraviolet spectra.The dissolution of ellagic acid in solid dispersions
Degree is increased to 0.4129mg/mL, the experiment proved that, anti-oxidant being enhanced of ellagic acid-PVP solid dispersions.Using 0.3g/
100mL ellagic acid-PVP solid dispersions handle refrigeration hairtail, compared to conventional preservation method, can extend Larimichthys crocea
2~3d of shelf life.A is the SEM image of ellagic acid in Fig. 1, and B is the SEM image of solid dispersions, as seen from the figure ellagic acid
Entirely different with the surface texture of solid dispersions, ellagic acid exists with crystal form, and solid dispersions are deposited with unformed state
There are many irregular holes not of uniform size, when being that coprecipitation prepares solid dispersions, second on, the surface of solid dispersions
Caused by the evaporation of alcohol, the presence of hole increases the surface area of solid dispersions, so that ellagic acid is easier to dissolve out, ellagic acid
Crystal is dispersed in water-solubility carrier, and the presence of water-solubility carrier inhibits the aggregation and growth of ellagic acid crystal, and SEM image is aobvious
Show that the crystallinity of ellagic acid reduces.
Wherein k30 is more common in PVP, and the PVP of different average molecular weight has different caking property, may be used to prepare
Solid dispersions.
Embodiment 2:
1, ellagic acid sieves with 100 mesh sieve 3-5 times, accurately weighs 1g ellagic acid and 5g PVPk30, completely molten under stirring
In the hot dehydrated alcohol of 60 DEG C of water bath processings of 120mL.
2, ultrasound treatment step (1) acquired solution 1h.
3, rotary evaporation removes vehicle of ethanol, scrapes the solid of revolving bottle inner wall, is put into baking oven and balances dry 8h.
4, it is sieved with 100 mesh sieve after mortar milled solids, obtained pale yellow powder is ellagic acid-PVP solid dispersions, dry
It saves.
Ellagic acid therein can be extracted from granatum.
Identify that ellagic acid and PVP are complexed successfully through infrared spectroscopy, ultraviolet spectra.The dissolution of ellagic acid in solid dispersions
Degree is increased to 0.4245mg/mL, the experiment proved that, anti-oxidant being enhanced of ellagic acid-PVP solid dispersions.
Claims (5)
1. a kind of preparation method of ellagic acid-PVP food fresh keeping solid dispersions, which comprises the steps of:
(1) by mass ratio be 1:(3~5) ellagic acid and PVP be completely dissolved in 60 DEG C of dehydrated alcohol.
(2) ultrasound treatment step (1) 0.5~1h of acquired solution.
(3) rotary evaporation removes vehicle of ethanol, scrapes the solid of revolving bottle inner wall, is put into baking oven and balances drying.
(4) pale yellow powder obtained is ellagic acid-PVP solid dispersions.
2. a kind of preparation method of ellagic acid-PVP food fresh keeping solid dispersions according to claim 1, feature exist
In ellagic acid is first crossed 80~100 meshes before being dissolved in 60 DEG C of dehydrated alcohol in the step (1).
3. a kind of preparation method of ellagic acid-PVP food fresh keeping solid dispersions according to claim 2, feature exist
In in the step (3), the revolving speed of the rotary evaporation is 50~80r/min, and temperature is 50~70 degree.
4. a kind of preparation method of ellagic acid-PVP food fresh keeping solid dispersions according to claim 3, feature exist
In balancing the dry time is 8~12h.
5. a kind of preparation method of ellagic acid-PVP food fresh keeping solid dispersions according to claim 4, feature exist
In balance is dry to use mortar milled solids, after 80~100 meshes.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910064270.1A CN109673736A (en) | 2019-01-23 | 2019-01-23 | A kind of preparation method of ellagic acid-PVP food fresh keeping solid dispersions |
| ZA2020/00201A ZA202000201B (en) | 2019-01-23 | 2020-01-13 | Preparation method of solid dispersion of ellagic acid-pvp for food preservation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910064270.1A CN109673736A (en) | 2019-01-23 | 2019-01-23 | A kind of preparation method of ellagic acid-PVP food fresh keeping solid dispersions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109673736A true CN109673736A (en) | 2019-04-26 |
Family
ID=66194363
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910064270.1A Pending CN109673736A (en) | 2019-01-23 | 2019-01-23 | A kind of preparation method of ellagic acid-PVP food fresh keeping solid dispersions |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN109673736A (en) |
| ZA (1) | ZA202000201B (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110292582A (en) * | 2019-08-08 | 2019-10-01 | 枣庄学院 | A kind of ellagic acid-montmorillonite effervescent agent and preparation method thereof |
| CN111228516A (en) * | 2020-01-20 | 2020-06-05 | 复旦大学附属肿瘤医院 | T1-MRI and photoacoustic bimodal imaging contrast agent and preparation method thereof |
| CN112106817A (en) * | 2020-10-19 | 2020-12-22 | 福建农林大学 | Pseudosciaena crocea preservative and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102871950A (en) * | 2011-07-15 | 2013-01-16 | 上海睿智化学研究有限公司 | Ursolic acid solid dispersion and preparation method thereof |
-
2019
- 2019-01-23 CN CN201910064270.1A patent/CN109673736A/en active Pending
-
2020
- 2020-01-13 ZA ZA2020/00201A patent/ZA202000201B/en unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102871950A (en) * | 2011-07-15 | 2013-01-16 | 上海睿智化学研究有限公司 | Ursolic acid solid dispersion and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| BIN LI等: "Stability and solubility enhancement of ellagic acid in cellulose ester solid dispersions", 《CARBOHYDRATE POLYMERS》 * |
| 鄢海燕等: "《药剂学 第2版》", 31 January 2018, 江苏凤凰科学技术出版社 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110292582A (en) * | 2019-08-08 | 2019-10-01 | 枣庄学院 | A kind of ellagic acid-montmorillonite effervescent agent and preparation method thereof |
| CN111228516A (en) * | 2020-01-20 | 2020-06-05 | 复旦大学附属肿瘤医院 | T1-MRI and photoacoustic bimodal imaging contrast agent and preparation method thereof |
| CN112106817A (en) * | 2020-10-19 | 2020-12-22 | 福建农林大学 | Pseudosciaena crocea preservative and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| ZA202000201B (en) | 2020-12-23 |
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