CN108371542A - A kind of eyeground multi-modal synchronization imaging system - Google Patents
A kind of eyeground multi-modal synchronization imaging system Download PDFInfo
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- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/12—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
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- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/102—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for optical coherence tomography [OCT]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/12—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
- A61B3/1225—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes using coherent radiation
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- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/14—Arrangements specially adapted for eye photography
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/14—Arrangements specially adapted for eye photography
- A61B3/15—Arrangements specially adapted for eye photography with means for aligning, spacing or blocking spurious reflection ; with means for relaxing
- A61B3/152—Arrangements specially adapted for eye photography with means for aligning, spacing or blocking spurious reflection ; with means for relaxing for aligning
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Abstract
Multi-modal synchronization imaging system in eyeground provided by the invention, by the way that line scanning fast imaging techniques and Optical Coherence Tomography Imaging Technology are combined, system hardware is effectively reduced using total light path resonant mirror synchronous scanning imaging method, and the scanning of optical coherence tomography is not influenced while solving lens and corneal reflection speck using hollow slots speculum, it realizes efficiently using for optical coherence tomography and line cofocus scanning speed, achievees the purpose that the imaging of quick face and the fault imaging of eye ground.
Description
Technical field
Belonging to optical imagery and biomedical diagnostic equipment the present invention relates to one kind more particularly to a kind of eyeground is multi-modal same
Walk imaging system.
Background technology
Clinically there is various fundus retina image-forming technology, including fundus camera at present, optical coherence tomography,
Cofocus scanning technology etc. all plays an important role to biological study and medical diagnosis on disease.
Laser cofocus scanning ophthalmoscope filters out the high-resolution imaging mode of veiling glare by numerous studies by being conjugated aperture,
And it is successfully applied to biological study and medical diagnosis, including on ophthalmology is imaged, and laser rays cofocus scanning technology is total in laser
Conjugation aperture conjugation slit is changed on the basis of coke scanning to substantially increase although sacrifice part imaging resolution
Image taking speed may be implemented compared to the fundus camera of strong optical flare exposure to eyeground high speed real time imagery.
Patent application CN104224109A discloses a kind of fundus camera of combination OCT systems, by fundus camera and optics
Coherence tomography techniques are combined, but since fundus camera is using flash exposure, strong light generates prodigious stimulation to eyes,
It cannot continue to be imaged；Patent application CN104684457A disclose using OCT light source and scanning optical device two dimension it is confocal at
The sample light of optical coherence tomography is taken imaging of the part as confocal imaging by picture, but laser cofocus scanning is imaged
It is transversal scanning, optical coherence tomography is longitudinal section scanning, very slow in horizontal direction speed, will largely effect on confocal imaging
Speed.
Invention content
Have in view of that, it is necessary to a kind of eyeground multi-modal synchronization imaging system is provided, by the way that line is scanned fast imaging skill
Art and Optical Coherence Tomography Imaging Technology are combined, and realize effective profit of optical coherence tomography and line cofocus scanning speed
With, achieve the purpose that eye ground quick face imaging and fault imaging.
To achieve the above object, the present invention uses following technical proposals:
On the one hand, multi-modal synchronization imaging system in eyeground provided by the invention, including optical coherence tomography module, slow axis are swept
It retouches module, image-forming module, hollow slots speculum, line scanning confocal lighting module, fast axle scan module and connects mesh object lens, institute
It states optical coherence tomography module and is used to form optical coherent chromatographic imaging sample light, the slow axis scan module includes slow axis scanning
Galvanometer and slow axis condenser lens, the image-forming module include condenser lens, spectroscope and detector, the line scanning confocal illumination
Module includes laser, first collimator and cylindrical mirror, and the fast axle scan module includes fast axle scanning galvanometer and scanning lens；Its
In：
The incident slow axis scanning galvanometer after the optical coherent chromatographic imaging sample light collimator collimation, then through described
The incident spectroscope after slow axis condenser lens, the sample light after spectroscope reflection are saturating after condenser lens focusing
Cross the slit of the hollow slots speculum；
The laser beam of the laser emitting enters after the first collimator, the cylindrical mirror described hollow narrow successively
Stitch speculum, slit of the laser beam after hollow slots speculum reflection with the transmission hollow slots speculum
Optical coherence tomography sample light be combined, formed combine light；
The combination light through the fast axle scanning galvanometer, scanning lens and after connecing mesh object lens to eyeground synchronize illumination at
Picture, the imaging of formation connect mesh object lens, the scanning lens, fast axle scanning described in warp successively after eye ground reflects
Galvanometer, the hollow slots speculum slit after enter the condenser lens, passed through again after condenser lens focusing described
The imaging of spectroscope transmission is simultaneously received and is imaged by the detector, again through the spectroscope after condenser lens focusing
The imaging of reflection is interfered through the slow axis condenser lens, the slow axis scanning galvanometer in the optical coherence tomography module successively
Imaging.
In some preferred embodiment, the optical coherence tomography module is swept-source optical coherence chromatography unit or spectrum
Domain optical coherence chromatography unit.
In some preferred embodiment, in the slow axis condenser lens in the slow axis scan module and the image-forming module
Condenser lens constitutes 4f systems.
In some preferred embodiment, the slow axis scanning galvanometer and the fast axle scanning galvanometer are in conjugate position.
In some preferred embodiment, the optical coherent chromatographic imaging sample light is after slow axis scanning galvanometer scanning
It is identical as slit direction in the scanning track of the hollow slots speculum.
In some preferred embodiment, the spectroscope is light splitting plain film or Amici prism or pellicle.
In some preferred embodiment, the hollow slots speculum is sheet glass or the cutting for being coated with slit reflectance coating
There is the speculum of slit.
In some preferred embodiment, cylindrical mirror non-aggregate direction and the slit direction of the hollow slots speculum are hung down
Directly, and the center of the fast axle scanning galvanometer is located at the focal point of the cylindrical mirror.
In some preferred embodiment, the hollow slots speculum is sheet glass or the cutting for being coated with slit reflectance coating
There is the speculum of slit.
The present invention uses above-mentioned technical proposal, can realize following advantageous effects：
Multi-modal synchronization imaging system in eyeground provided by the invention, the optical coherent chromatographic imaging sample light is through the first standard
The incident slow axis scanning galvanometer after straight device collimation, then the incident spectroscope after the slow axis condenser lens, through described point
Sample light after light microscopic reflection penetrates the slit of the hollow slots speculum after condenser lens focusing；The laser
The laser beam of outgoing enters the hollow slots speculum, the laser beam after the collimator, the cylindrical mirror successively
It is combined with the sample light of the slit through the hollow slots speculum after hollow slots speculum reflection, forms knot
Closing light；The combination light synchronizes illumination imaging through the fast axle scanning galvanometer, scanning lens and to eyeground after connecing mesh object lens,
The imaging of formation after eye ground reflects successively warp described in connect mesh object lens, the scanning lens, the fast axle scanning shake
Mirror, the hollow slots speculum slit after enter the condenser lens, again through described point after condenser lens focusing
The imaging of light microscopic transmission is simultaneously received and is imaged by the detector, anti-through the spectroscope again after condenser lens focusing
The imaging penetrated successively through the slow axis condenser lens, the slow axis scanning galvanometer the optical coherence tomography module interfere at
Picture, multi-modal synchronization imaging system in eyeground provided by the invention, by the way that line is scanned fast imaging techniques and optical coherence tomography
Imaging technique is combined, and effectively reduces system hardware using total light path resonant mirror synchronous scanning imaging method, and using hollow narrow
Seam speculum solves not influencing the scanning of optical coherence tomography while lens and corneal reflection speck, realizes optical coherence tomography
Technology and line cofocus scanning speed efficiently use, and achieve the purpose that the imaging of quick face and the fault imaging of eye ground.
Description of the drawings
Fig. 1 is the structural schematic diagram of multi-modal synchronization imaging system in eyeground provided in this embodiment.
Fig. 2 is the structural schematic diagram for the eyeground multi-modal synchronization imaging system that the embodiment of the present invention 1 provides.
Fig. 3 is the typical hollow slots speculum of two kinds of use that the embodiment of the present invention 1 provides.
Fig. 4 is the relation schematic diagram of slow axis scanning light beam track and slit that the embodiment of the present invention 1 provides.
Fig. 5 is the structural schematic diagram for the eyeground multi-modal synchronization imaging system that the embodiment of the present invention 2 provides.
Specific implementation mode
In order to make the purpose , technical scheme and advantage of the present invention be clearer, with reference to the accompanying drawings and embodiments, right
The present invention is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, and
It is not used in the restriction present invention.
Referring to Fig. 1, be multi-modal synchronization imaging system in eyeground provided in an embodiment of the present invention, including：Line scanning confocal
Lighting module 1, slow axis scan module 2, optical coherence tomography module 3, fast axle scan module 4, hollow slots speculum 5, imaging
Module 6 connects mesh object lens 7 and eye ground 8.Wherein：
The optical coherence tomography module 3 is used to form optical coherent chromatographic imaging sample light.The slow axis scan module 2
Including slow axis scanning galvanometer 21 and slow axis condenser lens 22.The image-forming module 6 includes condenser lens 61, spectroscope 62 and detection
Device 63.The line scanning confocal lighting module 1 includes laser 11, first collimator 12 and cylindrical mirror 13.The fast axle scans mould
Block 4 includes fast axle scanning galvanometer 41 and scanning lens 42.
Multi-modal synchronization imaging system in eyeground provided by the invention, working method are as follows：
The incident slow axis scanning galvanometer 21 after the optical coherent chromatographic imaging sample light collimator collimation, then through institute
State the incident spectroscope 62 after slow axis condenser lens 22, the sample light after the reflection of the spectroscope 62 again through it is described focus it is saturating
Mirror 61 penetrates the slit of the hollow slots speculum 5 after focusing；
The laser beam that the laser 11 is emitted enters after the first collimator 12, the cylindrical mirror 13 described successively
Hollow slots speculum 5, the laser beam reflect after the hollow slots speculum 5 reflection with through the hollow slots
The sample light of the slit of mirror 5 is combined, and is formed and is combined light；
The combination light synchronizes eyeground through the fast axle scanning galvanometer 41, scanning lens 42 and after connecing mesh object lens 7
Illumination imaging, the imaging of formation meet mesh object lens 7, the scanning lens 42, institute described in warp successively after the reflection of eye ground 8
Enter the condenser lens 61 after stating the slit of fast axle scanning galvanometer 41, the hollow slots speculum 5, through the condenser lens
61 focus after again through the spectroscope 62 transmit imaging and by the detector 63 receive and be imaged, through the condenser lens
The imaging reflected again through the spectroscope 62 after 61 focusing is successively through the slow axis condenser lens 22, the slow axis scanning galvanometer
21 in 3 interference imaging of optical coherence tomography module.
Multi-modal synchronization imaging system in eyeground provided by the invention is appreciated that, by the way that line is scanned fast imaging techniques
It is combined with Optical Coherence Tomography Imaging Technology, it is hard to effectively reduce system using total light path resonant mirror synchronous scanning imaging method
Part, and use hollow slots speculum solves not influencing the scanning of optical coherence tomography while lens and corneal reflection speck,
It realizes efficiently using for optical coherence tomography and line cofocus scanning speed, reaches the quick face imaging of eye ground and disconnected
The purpose of layer imaging.
Embodiment 1
Referring to Fig. 2, the structural schematic diagram of the eyeground multi-modal synchronization imaging system provided for the embodiment of the present invention 1.
In the present embodiment, optical coherence tomography module 3 is swept-source optical coherence chromatography unit, including：Light source 311,
First coupler 312, the second collimator 313, compensating glass 316, right-angle reflecting prism 317, third collimator 315, second couple
Device 318 and balanced detector 319.
Specifically, the light that the light source 311 of optical coherence tomography is sent out is divided into two parts light after the first coupler 312
Beam, a portion light beam are emitted after compensating glass 316, right-angle reflecting prism 317 by collimator 314 and are collimated device 316
It receives, and the second coupler 318 is reached as with reference to light；Another part light reaches 313 conduct of collimator from the first coupler 312
Optical coherent chromatographic imaging sample light, and the incident slow axis scanning galvanometer 21 after the outgoing of collimator 313, then through the slow axis
The incident spectroscope 62 after condenser lens 22, the sample light after the reflection of the spectroscope 62 are focused through the condenser lens 61
The slit of the hollow slots speculum 5 is penetrated afterwards.
The laser beam that the laser 11 is emitted enters after the first collimator 12, the cylindrical mirror 13 described successively
Hollow slots speculum 5, the laser beam reflect after the hollow slots speculum 5 reflection with through the hollow slots
The sample light of the slit of mirror 5 is combined, and is formed and is combined light；
The combination light synchronizes eyeground through the fast axle scanning galvanometer 41, scanning lens 42 and after connecing mesh object lens 7
Illumination imaging, the imaging of formation meet mesh object lens 7, the scanning lens 42, institute described in warp successively after the reflection of eye ground 8
Enter the condenser lens 61 after stating the slit of fast axle scanning galvanometer 41, the hollow slots speculum 5, through the condenser lens
61 focus after again through the spectroscope 62 transmit imaging and by the detector 63 receive and be imaged.
It is appreciated that the imaging reflected through the spectroscope 62 after the focusing of the condenser lens 61 is successively through described slow
Axis condenser lens 22, the slow axis scanning galvanometer 21 are collimated the reception of device 313, using the coupling of the first coupler 312, wherein
Most of light enters the second coupler 318, and imaging is interfered with reference light, is finally balanced detector 319 and receives and be imaged.
In some preferred embodiments, the swept light source model of the swept-source optical coherence chromatography unit
Santec-HSL-10, sweep velocity 100kHz, centre wavelength 1060nm.It is appreciated that the swept-source optical coherence layer
Swept light source model, sweep velocity and the centre wavelength of analysis unit do not limit to above-mentioned setting, in practice can be according to reality
Situation adjusts.
It is appreciated that the light that swept light source 311 is sent out is after 322 first coupler 312 of coupler, wherein 80% light
It is received again by third collimator 315 after the second collimator 313, compensating glass 316, right-angle reflecting prism 317, in addition 20%
Light reach collimator 313 be used as sample light.
In some preferred embodiments, the sweep speed of the fast axle scanning galvanometer is 200Hz, minute surface size
10mmX15mm.It is appreciated that in practice, the sweep speed and minute surface size of the fast axle scanning galvanometer can be according to reality
Situation adjusts.
For the sweep speed that the slow axis scanning galvanometer is set as 0.5Hz, model is identical with fast axle scanning galvanometer model, is
Cambridge 6220H, scanning axis direction are mutually perpendicular to.It is appreciated that the model of the slow axis scanning galvanometer is not limited to
Model is stated, can also be adjusted in practice according to actual conditions.
In some preferred embodiments, the slow axis condenser lens 22 and condenser lens 61 constitute 4f systems, and slow axis is swept
It retouches galvanometer and fast axle scanning galvanometer is respectively positioned on the lens focus position of the 4f systems.
In some preferred embodiments, the laser 11 of line scanning confocal lighting module 1 sends out the light of 650nm, passes through
Become the parallel hot spot that size is a diameter of 20mm after collimator 142, and line is pooled by the cylindrical mirror 13 that focal length is 40mm again
Light beam, light beam convergence direction is parallel with slit direction, and the light on optical axis direction has penetrated slit, the wide part on non-optical axis
It is reflected by hollow slots speculum.
Referring to Fig. 3, hollow slots speculum 5 is to be coated with the sheet glass (left side diagram) of slit reflectance coating or be cut into
The speculum (the right diagram) of slit, it is preferable that hollow slots speculum uses and is coated with the sheet glass with slit reflectance coating.
Referring to Fig. 4, the sample light of optical coherence tomography is after the scanning of slow axis scanning galvanometer 21, it is anti-by hollow slots
The slit of mirror 5 is penetrated, scanning direction is consistent with slit direction.
In some preferred embodiments, the spectroscope 62 is light splitting plain film or Amici prism or pellicle.It is preferred that
Ground, spectroscope model thorlabsDMSP805, short-pass, by wavelength be 805nm.
In some preferred embodiments, detector 63 model E2V-EM4,512pixels, maximum sample rate
210kHz。
The eyeground multi-modal synchronization imaging system that the above embodiment of the present invention provides, by the way that line is scanned fast imaging techniques
It is combined with Optical Coherence Tomography Imaging Technology, it is hard to effectively reduce system using total light path resonant mirror synchronous scanning imaging method
Part, and use hollow slots speculum solves not influencing the scanning of optical coherence tomography while lens and corneal reflection speck,
It realizes efficiently using for optical coherence tomography and line cofocus scanning speed, reaches the quick face imaging of eye ground and disconnected
The purpose of layer imaging.
Embodiment 2
Referring to Fig. 5, the structural schematic diagram of the eyeground multi-modal synchronization imaging system provided for the embodiment of the present invention 2.
In the present embodiment, optical coherence tomography module 3 is spectral domain optical coherent tomographic unit, including semiconductor laser
321, coupler 322, collimator 328, compensating glass 325, plane mirror 326, collimator 327, collimating mirror 328, grating 329,
Condenser lens 330 and line-scan digital camera 331.
The light source of the spectral domain optical coherent tomographic unit is semiconductor laser 321, model SLD-351, middle cardiac wave
A length of 830nm, bandwidth 80nm.
It is appreciated that the light that semiconductor laser 321 is sent out after coupler 322, collimates wherein 80% light passes through
Device 324, compensating glass 325, and received again by collimator 324 after being reflected by plane mirror 326；Other 20% light reaches accurate
Straight device 323 is used as sample light, and the incident slow axis scanning galvanometer 21 after the outgoing of collimator 323, then is focused through the slow axis
The incident spectroscope 62 after lens 22, the sample light after the reflection of the spectroscope 62 are saturating after the focusing of the condenser lens 61
Cross the slit of the hollow slots speculum 5.
The laser beam that the laser 11 is emitted enters after the collimator 12, the cylindrical mirror 13 described hollow successively
Slotted mirror 5, the laser beam after the hollow slots speculum 5 reflection with through the hollow slots speculum 5
The sample light of slit be combined, formed and combine light；
The combination light synchronizes eyeground through the fast axle scanning galvanometer 41, scanning lens 42 and after connecing mesh object lens 7
Illumination imaging, the imaging of formation meet mesh object lens 7, the scanning lens 42, institute described in warp successively after the reflection of eye ground 8
Enter the condenser lens 61 after stating the slit of fast axle scanning galvanometer 41, the hollow slots speculum 5, through the condenser lens
61 focus after again through the spectroscope 62 transmit imaging and by the detector 63 receive and be imaged.
It is appreciated that the imaging reflected through the spectroscope 62 after the focusing of the condenser lens 61 is successively through described slow
Axis condenser lens 22, the slow axis scanning galvanometer 21 are collimated the reception of device 323, are interfered into coupler 322 with reference light
Imaging, the light after interference enters collimator 327, and it is collimated light beam to be collimated the collimation of mirror 328, by grating 329 by each frequency spectrum
Light detaches, and after the focusing of condenser lens 330, is finally received by line-scan digital camera 331.
The eyeground multi-modal synchronization imaging system that the above embodiment of the present invention provides, by the way that line is scanned fast imaging techniques
It is combined with Optical Coherence Tomography Imaging Technology, it is hard to effectively reduce system using total light path resonant mirror synchronous scanning imaging method
Part, and use hollow slots speculum solves not influencing the scanning of optical coherence tomography while lens and corneal reflection speck,
It realizes efficiently using for optical coherence tomography and line cofocus scanning speed, reaches the quick face imaging of eye ground and disconnected
The purpose of layer imaging.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all essences in the present invention
All any modification, equivalent and improvement etc., should all be included in the protection scope of the present invention made by within refreshing and principle.
Claims (7)
1. a kind of eyeground multi-modal synchronization imaging system eyeground multi-modal synchronization imaging system, which is characterized in that including optics phase
Dried layer analyses module, slow axis scan module, image-forming module, hollow slots speculum, line scanning confocal lighting module, fast axle and scans mould
Block and mesh object lens are connect, the optical coherence tomography module is used to form optical coherent chromatographic imaging sample light, and the slow axis is swept
It includes slow axis scanning galvanometer and slow axis condenser lens to retouch module, and the image-forming module includes condenser lens, spectroscope and detector,
The line scanning confocal lighting module includes laser, first collimator and cylindrical mirror, and the fast axle scan module includes that fast axle is swept
Retouch galvanometer and scanning lens；Wherein：
The incident slow axis scanning galvanometer after the optical coherent chromatographic imaging sample light collimator collimation, then through the slow axis
The incident spectroscope after condenser lens, the sample light after spectroscope reflection penetrate institute after condenser lens focusing
State the slit of hollow slots speculum；
It is anti-that the laser beam of the laser emitting enters the hollow slots after the first collimator, the cylindrical mirror successively
Penetrate mirror, light of the laser beam after hollow slots speculum reflection with the slit through the hollow slots speculum
It learns coherent tomographic sample light to be combined, is formed and combine light；
The combination light synchronizes illumination imaging through the fast axle scanning galvanometer, scanning lens and to eyeground after connecing mesh object lens,
The imaging of formation after eye ground reflects successively warp described in connect mesh object lens, the scanning lens, the fast axle scanning shake
Mirror, the hollow slots speculum slit after enter the condenser lens, again through described point after condenser lens focusing
The imaging of light microscopic transmission is simultaneously received and is imaged by the detector, anti-through the spectroscope again after condenser lens focusing
The imaging penetrated successively through the slow axis condenser lens, the slow axis scanning galvanometer the optical coherence tomography module interfere at
Picture.
2. multi-modal synchronization imaging system in eyeground according to claim 1, which is characterized in that the optical coherence tomography mould
Block is that swept-source optical coherence chromatographs module or spectral domain optical coherent tomographic module.
3. multi-modal synchronization imaging system in eyeground according to claim 1, which is characterized in that in the slow axis scan module
Slow axis condenser lens and the image-forming module in condenser lens constitute 4f systems, slow axis scanning galvanometer and fast axle scanning
Galvanometer is respectively at the focal position of two lens of 4f systems.
4. multi-modal synchronization imaging system in eyeground according to claim 1, which is characterized in that the optical coherence tomography at
Decent product light is identical as slit direction in the scanning track of the hollow slots speculum after slow axis scanning galvanometer scanning.
5. multi-modal synchronization imaging system in eyeground according to claim 1, which is characterized in that the spectroscope is that light splitting is flat
Piece or Amici prism or pellicle.
6. multi-modal synchronization imaging system in eyeground according to claim 1, which is characterized in that the hollow slots speculum
To be coated with the sheet glass of slit reflectance coating or being cut with the speculum of slit.
7. multi-modal synchronization imaging system in eyeground according to claim 1, which is characterized in that cylindrical mirror non-aggregate direction
It is vertical with the slit direction of hollow slots speculum.
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| CN109744997A (en) * | 2019-01-18 | 2019-05-14 | 中国科学院苏州生物医学工程技术研究所 | A kind of retina image-forming method and system |
| CN109924942A (en) * | 2019-04-25 | 2019-06-25 | 南京博视医疗科技有限公司 | A kind of photorefractive crystals method and system based on Line-scanning Image Acquisition System |
| CN110115559A (en) * | 2019-03-07 | 2019-08-13 | 中国科学院苏州生物医学工程技术研究所 | Eyeground multi-modal synchronization imaging system |
| CN110448266A (en) * | 2018-12-29 | 2019-11-15 | 中国科学院宁波工业技术研究院慈溪生物医学工程研究所 | Random Laser is copolymerized focal line and scans three-dimensional ophthalmoscope and imaging method |
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| CN112155512A (en) * | 2020-09-30 | 2021-01-01 | 广东唯仁医疗科技有限公司 | Optical coherence tomography imaging equipment and control method thereof |
| CN112168136A (en) * | 2020-09-27 | 2021-01-05 | 中国科学院光电技术研究所 | Scanning-free three-dimensional optical coherence tomography angiography and tissue structure imaging system and method |
| CN112587302A (en) * | 2021-03-04 | 2021-04-02 | 季华实验室 | Femtosecond laser real-time dynamic positioning focusing system and method |
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