CN108367151A - 神经调节设备 - Google Patents

神经调节设备 Download PDF

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Publication number
CN108367151A
CN108367151A CN201680061734.8A CN201680061734A CN108367151A CN 108367151 A CN108367151 A CN 108367151A CN 201680061734 A CN201680061734 A CN 201680061734A CN 108367151 A CN108367151 A CN 108367151A
Authority
CN
China
Prior art keywords
signal
optionally
patient
nerve
vagus nerve
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201680061734.8A
Other languages
English (en)
Chinese (zh)
Inventor
M.J.卡尔
G.E.亨伯格
K.K.邝
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlaxoSmithKline Intellectual Property Development Ltd
Original Assignee
GlaxoSmithKline Intellectual Property Development Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GlaxoSmithKline Intellectual Property Development Ltd filed Critical GlaxoSmithKline Intellectual Property Development Ltd
Publication of CN108367151A publication Critical patent/CN108367151A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/205—Applying electric currents by contact electrodes continuous direct currents for promoting a biological process
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36053—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for vagal stimulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Measuring devices for evaluating the respiratory organs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Measuring devices for evaluating the respiratory organs
    • A61B5/0816—Measuring devices for examining respiratory frequency
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Measuring devices for evaluating the respiratory organs
    • A61B5/087—Measuring breath flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Measuring devices for evaluating the respiratory organs
    • A61B5/091—Measuring volume of inspired or expired gases, e.g. to determine lung capacity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14542—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring blood gases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316—Modalities, i.e. specific diagnostic methods
    • A61B5/388—Nerve conduction study, e.g. detecting action potential of peripheral nerves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/40—Detecting, measuring or recording for evaluating the nervous system
    • A61B5/4029—Detecting, measuring or recording for evaluating the nervous system for evaluating the peripheral nervous systems
    • A61B5/4035—Evaluating the autonomic nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36057—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for stimulating afferent nerves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/3611—Respiration control
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36135—Control systems using physiological parameters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36146—Control systems specified by the stimulation parameters
    • A61N1/36167—Timing, e.g. stimulation onset
    • A61N1/36171—Frequency

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Surgery (AREA)
  • Medical Informatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pathology (AREA)
  • Pulmonology (AREA)
  • Physiology (AREA)
  • Optics & Photonics (AREA)
  • Electrotherapy Devices (AREA)
CN201680061734.8A 2015-08-21 2016-08-18 神经调节设备 Pending CN108367151A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562208057P 2015-08-21 2015-08-21
US62/208057 2015-08-21
PCT/IB2016/054957 WO2017033101A1 (en) 2015-08-21 2016-08-18 Neuromodulation device

Publications (1)

Publication Number Publication Date
CN108367151A true CN108367151A (zh) 2018-08-03

Family

ID=56853696

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201680061734.8A Pending CN108367151A (zh) 2015-08-21 2016-08-18 神经调节设备

Country Status (11)

Country Link
US (2) US11878160B2 (enExample)
EP (2) EP3337556B1 (enExample)
JP (1) JP2018523542A (enExample)
KR (1) KR20180044941A (enExample)
CN (1) CN108367151A (enExample)
AU (1) AU2016310626A1 (enExample)
BR (1) BR112018003107A2 (enExample)
CA (1) CA2996252A1 (enExample)
ES (2) ES2914685T3 (enExample)
RU (1) RU2018105336A (enExample)
WO (1) WO2017033101A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109045468A (zh) * 2018-08-09 2018-12-21 西安八水健康科技有限公司 一种耳部迷走神经刺激系统及其装置

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11571574B2 (en) 2016-11-11 2023-02-07 Galvani Bioelectronics Limited Treatment of diseases mediated by thyroid and parathyroid hormones
US20230139790A1 (en) * 2020-01-23 2023-05-04 Saluda Medical Pty Ltd Neuromodulation of Primary and/or Postsynaptic Neurons

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070027496A1 (en) * 2005-07-28 2007-02-01 Cyberonics, Inc. Stimulating cranial nerve to treat pulmonary disorder
CN101124012A (zh) * 2004-12-27 2008-02-13 范因斯坦医学研究院 通过电刺激迷走神经治疗炎症性疾病
CN101674862A (zh) * 2005-11-10 2010-03-17 电子核心公司 支气管收缩的电刺激治疗
US20100217347A1 (en) * 2006-12-16 2010-08-26 Greatbatch, Inc. Neurostimulation for the treatment of pulmonary disorders
US8483831B1 (en) * 2008-02-15 2013-07-09 Holaira, Inc. System and method for bronchial dilation
US20130238050A1 (en) * 2009-03-20 2013-09-12 ElectroCore, LLC. Non-invasive vagal nerve stimulation to treat disorders
CN103517732A (zh) * 2011-03-10 2014-01-15 电核有限责任公司 用于无创电容式电刺激的设备和方法以及它们用于对患者颈部的迷走神经刺激的用途
US20150202437A1 (en) * 2014-01-17 2015-07-23 Cardiac Pacemakers, Inc. Systems and methods for delivering pulmonary therapy

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993002744A1 (en) 1991-08-09 1993-02-18 Cyberonics, Inc. Treatment of anxiety disorders by nerve stimulation
US8812112B2 (en) * 2005-11-10 2014-08-19 ElectroCore, LLC Electrical treatment of bronchial constriction
EP2320821B2 (en) * 2008-05-09 2020-12-30 Nuvaira, Inc. Systems for treating a bronchial tree
US20120302909A1 (en) * 2009-11-11 2012-11-29 Mayse Martin L Methods and systems for screening subjects
US9398933B2 (en) 2012-12-27 2016-07-26 Holaira, Inc. Methods for improving drug efficacy including a combination of drug administration and nerve modulation
JP2015008746A (ja) * 2013-06-26 2015-01-19 オリンパス株式会社 神経刺激装置、副作用予測装置および神経刺激装置の作動方法
US9737716B2 (en) * 2014-08-12 2017-08-22 Cyberonics, Inc. Vagus nerve and carotid baroreceptor stimulation system

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101124012A (zh) * 2004-12-27 2008-02-13 范因斯坦医学研究院 通过电刺激迷走神经治疗炎症性疾病
US20070027496A1 (en) * 2005-07-28 2007-02-01 Cyberonics, Inc. Stimulating cranial nerve to treat pulmonary disorder
CN101674862A (zh) * 2005-11-10 2010-03-17 电子核心公司 支气管收缩的电刺激治疗
US20100217347A1 (en) * 2006-12-16 2010-08-26 Greatbatch, Inc. Neurostimulation for the treatment of pulmonary disorders
US8483831B1 (en) * 2008-02-15 2013-07-09 Holaira, Inc. System and method for bronchial dilation
US20130238050A1 (en) * 2009-03-20 2013-09-12 ElectroCore, LLC. Non-invasive vagal nerve stimulation to treat disorders
CN103517732A (zh) * 2011-03-10 2014-01-15 电核有限责任公司 用于无创电容式电刺激的设备和方法以及它们用于对患者颈部的迷走神经刺激的用途
US20150202437A1 (en) * 2014-01-17 2015-07-23 Cardiac Pacemakers, Inc. Systems and methods for delivering pulmonary therapy

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109045468A (zh) * 2018-08-09 2018-12-21 西安八水健康科技有限公司 一种耳部迷走神经刺激系统及其装置

Also Published As

Publication number Publication date
BR112018003107A2 (en) 2018-09-25
EP4052756A1 (en) 2022-09-07
CA2996252A1 (en) 2017-03-02
US20240131327A1 (en) 2024-04-25
ES2914685T3 (es) 2022-06-15
US11878160B2 (en) 2024-01-23
US20180236224A1 (en) 2018-08-23
EP3337556A1 (en) 2018-06-27
JP2018523542A (ja) 2018-08-23
KR20180044941A (ko) 2018-05-03
EP4052756B1 (en) 2024-05-15
EP3337556B1 (en) 2022-05-25
RU2018105336A (ru) 2019-09-23
WO2017033101A1 (en) 2017-03-02
AU2016310626A1 (en) 2018-03-08
ES2982192T3 (es) 2024-10-15

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Legal Events

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WD01 Invention patent application deemed withdrawn after publication
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Application publication date: 20180803