BR112018003107A2 - aparelho para estimular atividade neural em um nervo vago, método para tratar broncoconstrição, broncodilatador, forma de onda elétrica neuromodulatória, uso de um dispositivo de neuromodulação, e, sistema de neuromodulação - Google Patents

aparelho para estimular atividade neural em um nervo vago, método para tratar broncoconstrição, broncodilatador, forma de onda elétrica neuromodulatória, uso de um dispositivo de neuromodulação, e, sistema de neuromodulação

Info

Publication number
BR112018003107A2
BR112018003107A2 BR112018003107A BR112018003107A BR112018003107A2 BR 112018003107 A2 BR112018003107 A2 BR 112018003107A2 BR 112018003107 A BR112018003107 A BR 112018003107A BR 112018003107 A BR112018003107 A BR 112018003107A BR 112018003107 A2 BR112018003107 A2 BR 112018003107A2
Authority
BR
Brazil
Prior art keywords
vagus nerve
neural activity
neuromodulation
bronchodilator
electrical waveform
Prior art date
Application number
BR112018003107A
Other languages
English (en)
Inventor
E Hunsberger Gerald
K Kwong Kevin
John Carr Michael
Original Assignee
Galvani Bioelectronics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galvani Bioelectronics Ltd filed Critical Galvani Bioelectronics Ltd
Publication of BR112018003107A2 publication Critical patent/BR112018003107A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/205—Applying electric currents by contact electrodes continuous direct currents for promoting a biological process
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36053—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for vagal stimulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
    • A61B5/0816—Measuring devices for examining respiratory frequency
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
    • A61B5/087—Measuring breath flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
    • A61B5/091—Measuring volume of inspired or expired gases, e.g. to determine lung capacity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14542—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring blood gases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316—Modalities, i.e. specific diagnostic methods
    • A61B5/388—Nerve conduction study, e.g. detecting action potential of peripheral nerves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/40—Detecting, measuring or recording for evaluating the nervous system
    • A61B5/4029—Detecting, measuring or recording for evaluating the nervous system for evaluating the peripheral nervous systems
    • A61B5/4035—Evaluating the autonomic nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36057—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for stimulating afferent nerves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/3611—Respiration control
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36135—Control systems using physiological parameters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36146—Control systems specified by the stimulation parameters
    • A61N1/36167—Timing, e.g. stimulation onset
    • A61N1/36171—Frequency

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Pulmonology (AREA)
  • Physiology (AREA)
  • Optics & Photonics (AREA)
  • Electrotherapy Devices (AREA)

Abstract

a presente invenção provê dispositivos e métodos que podem prevenir ou melhorar broncoconstrição estimulando atividade neural, em contraste àquelas técnicas baseadas em desnervação, ablação ou bloqueio da atividade neural. métodos e dispositivos de acordo com a invenção podem atuar responsivamente ou sob demanda, podem preservar estrutura e função neuronal e serão associados com efeitos secundários colaterais mínimos. em particular, a invenção provê dispositivos e métodos nos quais um sinal é distribuído para o nervo vago, por exemplo o nervo vago cervical ou o ramo pulmonar do nervo vago, a fim de estimular atividade neural no nervo vago.
BR112018003107A 2015-08-21 2016-08-18 aparelho para estimular atividade neural em um nervo vago, método para tratar broncoconstrição, broncodilatador, forma de onda elétrica neuromodulatória, uso de um dispositivo de neuromodulação, e, sistema de neuromodulação BR112018003107A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562208057P 2015-08-21 2015-08-21
PCT/IB2016/054957 WO2017033101A1 (en) 2015-08-21 2016-08-18 Neuromodulation device

Publications (1)

Publication Number Publication Date
BR112018003107A2 true BR112018003107A2 (pt) 2018-09-25

Family

ID=56853696

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018003107A BR112018003107A2 (pt) 2015-08-21 2016-08-18 aparelho para estimular atividade neural em um nervo vago, método para tratar broncoconstrição, broncodilatador, forma de onda elétrica neuromodulatória, uso de um dispositivo de neuromodulação, e, sistema de neuromodulação

Country Status (11)

Country Link
US (2) US11878160B2 (pt)
EP (2) EP4052756B1 (pt)
JP (1) JP2018523542A (pt)
KR (1) KR20180044941A (pt)
CN (1) CN108367151A (pt)
AU (1) AU2016310626A1 (pt)
BR (1) BR112018003107A2 (pt)
CA (1) CA2996252A1 (pt)
ES (1) ES2914685T3 (pt)
RU (1) RU2018105336A (pt)
WO (1) WO2017033101A1 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018087330A1 (en) 2016-11-11 2018-05-17 Galvani Bioelectronics Limited Treatment of diseases mediated by thyroid and parathyroid hormones
CN109045468B (zh) * 2018-08-09 2022-05-24 西安科悦医疗技术有限公司 一种耳部迷走神经刺激系统及其装置

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2399892A (en) 1991-08-09 1993-03-02 Cyberonics, Inc. Treatment of anxiety disorders by nerve stimulation
DE602005025020D1 (de) * 2004-12-27 2011-01-05 The Feinstein Inst Medical Res Behandlung von entzündlichen erkrankungen durch el
US8660647B2 (en) 2005-07-28 2014-02-25 Cyberonics, Inc. Stimulating cranial nerve to treat pulmonary disorder
US8874227B2 (en) * 2009-03-20 2014-10-28 ElectroCore, LLC Devices and methods for non-invasive capacitive electrical stimulation and their use for vagus nerve stimulation on the neck of a patient
US8812112B2 (en) * 2005-11-10 2014-08-19 ElectroCore, LLC Electrical treatment of bronchial constriction
US7747324B2 (en) * 2005-11-10 2010-06-29 Electrocore Llc Electrical stimulation treatment of bronchial constriction
US20100217347A1 (en) * 2006-12-16 2010-08-26 Greatbatch, Inc. Neurostimulation for the treatment of pulmonary disorders
US8483831B1 (en) 2008-02-15 2013-07-09 Holaira, Inc. System and method for bronchial dilation
EP4166107A1 (en) * 2008-05-09 2023-04-19 Nuvaira, Inc. Systems, assemblies, and methods for treating a bronchial tree
US8843210B2 (en) * 2009-03-20 2014-09-23 ElectroCore, LLC Non-invasive vagal nerve stimulation to treat disorders
US20120302909A1 (en) * 2009-11-11 2012-11-29 Mayse Martin L Methods and systems for screening subjects
US9398933B2 (en) * 2012-12-27 2016-07-26 Holaira, Inc. Methods for improving drug efficacy including a combination of drug administration and nerve modulation
US20150202444A1 (en) 2014-01-17 2015-07-23 Cardiac Pacemakers, Inc. Systems and methods for selective stimulation of nerve fibers in carotid sinus

Also Published As

Publication number Publication date
US20240131327A1 (en) 2024-04-25
RU2018105336A (ru) 2019-09-23
EP3337556B1 (en) 2022-05-25
EP4052756A1 (en) 2022-09-07
JP2018523542A (ja) 2018-08-23
ES2914685T3 (es) 2022-06-15
AU2016310626A1 (en) 2018-03-08
KR20180044941A (ko) 2018-05-03
EP3337556A1 (en) 2018-06-27
WO2017033101A1 (en) 2017-03-02
US11878160B2 (en) 2024-01-23
US20180236224A1 (en) 2018-08-23
CA2996252A1 (en) 2017-03-02
CN108367151A (zh) 2018-08-03
EP4052756B1 (en) 2024-05-15

Similar Documents

Publication Publication Date Title
BR112017004047A2 (pt) sistema e método para bloquear seletivamente a atividade de fibra nervosa
EP3503959A4 (en) SYSTEMS AND METHODS FOR TREATING CARDIAC DYSFUNCTION BY STIMULATION OF PERIPHERAL NERVE
MX364276B (es) Método y sistema para la identificación de fuentes de dolor crónico y su tratamiento.
BR112016025203A8 (pt) Sistema transcutâneo para tratar um paciente que sofre de tremor
IL264116A (en) Systems and methods for stimulating nerves using the same number of electrodes as the number of nerves and improved dry electrodes
BR112018002218A2 (pt) aparelho para modular a atividade neural de fibras aferentes, método para tratamento de disfunção da bexiga, forma de onda elétrica neuromodulatória, uso de um aparelho de neuromodulação, composição farmacêutica, e, sistema de neuromodulação
SG11202005570XA (en) Computer-implemented systems and methods for authorising blockchain transactions with low-entropy passwords
WO2014118782A3 (en) Methods and systems for reducing neural activity in an organ of a subject
EP3352843A4 (en) SYSTEMS AND METHOD FOR PERIPHERAL NERVE STIMULATION IN THE FINGER OR IN THE HAND TO TREAT HAND TREMORES
BR112015017042A8 (pt) Dispositivos e métodos para controlar tremor
BR112017022941A2 (pt) dispositivo de neuromodulação
SG11201911672UA (en) System and method to stimulate the optic nerve
PH12018500187A1 (en) Gamma secretase modulators for the treatment of immune system dysfunction
BR112017013892A2 (pt) métodos e dispositivos para inibir nervos ao ativar o tecido adiposo marrom
BR112017009053A2 (pt) dispositivo para inibição da atividade neural de um nervo do seio carotídeo ou corpo carotídeo, método para tratamento de uma condição, forma de onda elétrica neuromodulatória, e, uso de um dispositivo de neuromodulação para o tratamento de uma condição.
EP3484577A4 (en) METHODS AND SYSTEMS FOR THE TREATMENT OF PELVIC DISORDERS AND PAINFUL CONDITIONS
BR112015030265A2 (pt) método implementado em computador para provisão de um programa de estímulo craniano por eletroterapia para uso em um sistema de estímulo, método implementado em computador de geração de uma forma de onda tpcs, aparelho, gerador de estímulo transcraniano por corrente pulsada, método para provisão de um regime de tratamento por estímulo transcraniano por corrente pulsada, e, método para provisão de um programa de estímulo craniano por eletroterapia caótica para uso em um sistema de estímulo
WO2012075337A3 (en) Agent delivery systems for selective neuromodulation
WO2015187247A3 (en) Biomimetic multichannel neurostimulation
EP3256212A4 (en) Systems and methods for targeted uvb phototherapy for dermatologic disorders and other indications
EP3752243A4 (en) SYSTEMS AND METHODS OF TREATING BRAIN DISEASE USING TARGETED NEUROSTIMULATION
IL280447A (en) A device for controlling brain waves and cell activity and a method based on stimulation with light and a device for improving, preventing or enhancing brain function
MX2019004101A (es) Metodo y sistema para monitorear y tratar una afeccion medica a traves de la estimulacion del nervio tibial posterior.
BR112018005855A2 (pt) tratamento de doenças neurodegenerativas
BR112018003107A2 (pt) aparelho para estimular atividade neural em um nervo vago, método para tratar broncoconstrição, broncodilatador, forma de onda elétrica neuromodulatória, uso de um dispositivo de neuromodulação, e, sistema de neuromodulação

Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]