CN108362674A - A kind of portable blood fluorescence immunity analyzer - Google Patents
A kind of portable blood fluorescence immunity analyzer Download PDFInfo
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- CN108362674A CN108362674A CN201810304921.5A CN201810304921A CN108362674A CN 108362674 A CN108362674 A CN 108362674A CN 201810304921 A CN201810304921 A CN 201810304921A CN 108362674 A CN108362674 A CN 108362674A
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- 238000009434 installation Methods 0.000 claims description 4
- 238000012216 screening Methods 0.000 abstract description 20
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/80—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood groups or blood types or red blood cells
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Abstract
The present invention discloses a kind of portable blood fluorescence immunity analyzer, the analyzer includes testing agency, master control borad, data memory module and the detection Kato disk for transmitting microscope carrier detection card, and the testing agency includes alanine aminotransferase detection module, four detection modules of fluorescence infectious disease, Blood grouping module and hemoglobin detection module.The present invention is directed to the entry detection needed in blood screening joint detection process, coordinates blood screening joint detection card, can be quick, is accurately detected the control of reaction condition and voluntarily completes the interpretation and output of multinomial testing result.
Description
Technical field
The invention belongs to the field of medical instrument technology, and in particular to a kind of portable blood fluorescence immunity analyzer, this is just
It takes formula Blood fluorescence immunity analysis instrument cooperation portable blood detection and analysis card and is used for blood safety screening before the urgent blood transfusion of field operation,
Preoperative blood screening, the preliminary screening of blood safety before the blood sampling of street corner.
Background technology
The safe screening method of blood mainly has fluoroimmunoassay, solid phase percolation, dry chemical performance rate method to do at present
Chemical spotting method etc., but be mostly individual event detection in blood screening detection product on the market, detection reagent is mostly sentenced with naked eyes
It reads, using the product of instrument interpretation more or less there is complicated for operation, instrument is heavy, and detection time is long, can not take with oneself
The shortcomings that band.To cover project few there is also detection for a small number of joint-detection products, cannot meet a card and meet multinomial blood sieve
The requirement looked into, and it is low to there is a situation where that detection accuracy is detected compared with individual event.Major blood screening on the market detects product at present
Such as gold mark readout instrument is separately self-existent with dry type chemical analysis instrument, and carried out for single detection project mostly
Single channel detection, encountering can only be carried out when entry being needed to detect by different detecting instruments, and more people detection when deposit
In serious efficiency.Therefore need to provide a kind of portable blood detection and analysis card suitable for entry detection, just
Take formula Blood fluorescence immunity analysis instrument and the safe screening fluoroimmunoassay system of portable blood.
Invention content
Blood screening detection product on the market is mostly individual event detection at present, and there is detections to contain for a small number of joint-detection products
Lid project is not complete, cumbersome, cannot meet the requirement that a card meets multinomial blood screening, there are higher using artificial interpretation
Error possibility, it is low that multinomial joint-detection has that accuracy of detection is detected compared with individual event.It is an object of the invention to be directed to
Upper technical problem provides a kind of portable blood fluorescence immunity analyzer.
The purpose of the present invention can be achieved through the following technical solutions：
A kind of portable blood fluorescence immunity analyzer, the analyzer include testing agency, master control borad, data memory module
With for transmit microscope carrier detection card detection Kato disk, the testing agency include alanine aminotransferase detection module,
Four detection modules of fluorescence infectious disease, Blood grouping module and hemoglobin detection module；
The hemoglobin detection module is fixed on the bottom of the detection Kato disk, the lower section of the detection Kato disk
It is also equipped with warm bath module, the detection Kato plate rail is located on bottom plate and drives its disengaging to move by driving device I；
Guide rail is vertically installed on the bottom plate, the alanine aminotransferase detection module passes through structure
Holder is assemblied on the sliding block of the guide rail, and the alanine aminotransferase detection module is driven by driving device II
It moves up and down above the detection Kato disk；
The Blood grouping module is installed on the module installing zone of structural member holder, the backlight of the structural member holder
Fluorescence-exciting radiation of the backlight for four detections of infectious disease is also equipped on plate installing zone, the structural member holder is fixed
It is installed on the lower section of fixed plate, described four detection modules of fluorescence infectious disease are fixedly installed in the top of the fixed plate, institute
The master control board stacking stated is fixed on the top of four detection modules of fluorescence infectious disease；
The fixed plate is fixed on by stud on the bottom plate；
Data memory module, the warm bath module and each module of the testing agency is connected by FPC lines
Connect the master control borad.
As a kind of optimal technical scheme, shell is provided with outside the Portable fluorescence immunity analysis instrument, described is outer
Shell is divided into upper shell and lower housing.The bottom plate is fixedly mounted on the lower housing, and the data memory module is solid
It is scheduled on the panel-mounted position of the upper shell.
It is further preferred that the analyzer further includes printer, display screen, key panel, power interface, PS2 scanners
At least one of interface and USB interface component.
The printer is installed on the printer assembly position of the upper shell and is connected to interface board by FPC lines,
The interface board is installed on the lower housing；The display screen is installed on the display window in the upper shell centre position
In mouthful, and master control borad is connected to by FPC lines；The key panel is installed on the button installation position of the upper shell and leads to
It crosses FPC lines and is connected to master control borad.
The power interface is inputted for working power and reserve battery charging, the reserve battery are assemblied in lower casing
In the battery settling groove of body.
Still more preferably, the driving device I includes direct current generator and screw rod, and the direct current generator passes through spiral shell
The bar connection detection Kato disk, the direct current generator drive the disengaging campaign of the detection Kato disk.
The detection Kato disk is located at by two support brackets being set up in parallel on bottom plate, the both ends of the support shaft
It is separately fixed on the bottom plate.
The driving device II is stepper motor, and the stepper motor is fixedly mounted on the vertical of the fixed plate and connects
On fishplate bar.
In the instrument, the detection Kato disk is used to detect the transmission microscope carrier of card.The printer is preferably that temperature-sensitive is beaten
Print machine is as data-printing output equipment.
The display screen is as presentation of information, indicating equipment.
The human-computer interaction device that the key panel sets or selects as function.
The PS2 scanner interfaces are as bar code scanner input equipment.
The USB interface is as USB principal and subordinate links equipment, it can be achieved that data storage, data-transformation facility.
The power interface charges for power work power input and reserve battery.
The data memory module is preferably the input that RFID module is used to detect the information such as card batch, parameter, and its
The preservation of detection data after test.
Up and down motion of the guide rail for alanine aminotransferase detection module is oriented to.The stepper motor is for driving
Dynamic alanine aminotransferase detection module moves up and down.
The master control borad coordinates the normal work of each electric component of instrument internal for Comprehensive Control.
According to the reaction principle of blood screening joint survey card, instrument of the invention uses detection end-point method, detection speed
Rate method, the integrated use of Machine Vision Recognition method.Detect end-point method and detection rates method on biochemical analyzer all at
Ripe utilization；Machine Vision Recognition method, currently on the market with the present invention is closest gold mark readout instrument, dry type chemical analysis instrument.
Compared with other detecting instruments, this patent portable blood fluorescence immunity analyzer is using semi-automatic detection mould
Formula, it is small, it is light-weight, it is easy to carry, and shock resistance is strong, and it can be quick, it is accurately detected the control of reaction temperature and time,
And analysis interpretation voluntarily is carried out to testing result, testing result output is completed in ten minutes.
Key Term is explained：
A) portable：It is mainly characterized by it is easy to carry, it is light and have stronger shock-resistance features, be suitble to field situation make
With.
B) blood safety screening：Different general individual event screening, the blood safety screening mentioned in this patent are comprehensive
Entry screening, usual blood screening include that blood group ABO is detected with blood group RhD sizings according to national regulation, and alanine amino turns
Move enzyme detection, hemoglobin detection, infectious disease four (hepatitis B surface antibody, AIDS, syphilis, hepatitis) detection；Preoperative blood sieve
It looks into.
C) fluorescence immunoassay：Use fluorescence immunoassay label that cross-linking method is immunized with antigen-antibody in this patent.
D) analysis system：It is tested and analyzed comprising portable blood fluorescence immunity analyzer and portable blood in this patent
Card, is collectively referred to as the safe screening fluoroimmunoassay system of portable blood.
Beneficial effects of the present invention：
The present invention is directed to the entry detection needed in blood screening joint detection process, cooperation portable blood detection point
Analysis card, can be quick, is accurately detected the control of reaction condition and voluntarily completes the interpretation and output of multinomial testing result.
Description of the drawings
Fig. 1 is the functional block diagram of Portable fluorescence immunity analysis instrument.
Fig. 2 is the workflow of Portable fluorescence immunity analysis instrument.
Fig. 3 is the appearance shape figure of Portable fluorescence immunity analysis instrument.
Fig. 4 is the internal structure chart of Portable fluorescence immunity analysis instrument.
Fig. 5 is that (A is the back side stereochemical structure of upper shell for the shape and structure figure of Portable fluorescence immunity analysis instrument upper shell
Figure, B are the front three-dimensional structure diagram of upper shell).
Fig. 6 is the shape and structure figure of the structural member holder and backlight of Portable fluorescence immunity analysis instrument.
Fig. 7 is the shape and structure figure of the fixed plate of Portable fluorescence immunity analysis instrument.
Fig. 8 is the shape and structure figure of the bottom plate of Portable fluorescence immunity analysis instrument.
Fig. 9 be the detection Kato disk of Portable fluorescence immunity analysis instrument shape and structure figure (A be detect Kato disk the back side
Three-dimensional structure diagram, B are the front three-dimensional structure diagram for detecting Kato disk).
Figure 10 is that (A is the three-dimensional knot in front of lower housing for the shape and structure figure of the lower housing of Portable fluorescence immunity analysis instrument
Composition, B are the back side three-dimensional structure diagram of lower housing).
Figure 11 is the upper section structural shape graph of warm bath module point.
Figure 12 is that warm bath module divides lower part structural member shape graph.
Figure 13：Portable blood tests and analyzes card structure figure (multinomial comprehensive detection reagent mode card).
Figure 14：Portable blood tests and analyzes card structure figure (individual event detection reagent mode card).
Figure 15：Blood grouping reagent card structural schematic diagram.
Figure 16：Blood grouping strip structural schematic diagram.
Figure 17：Four detection reagent card structure schematic diagrames of infectious disease.
Figure 18：Four detection strip structural schematic diagrams of infectious disease.
Figure 19：ALT detection reagent card structure schematic diagrames.
Figure 20：Hemoglobin detection reagent card structure schematic diagram.
Figure 21：Portable blood tests and analyzes card back structures schematic diagram.
Specific implementation mode
The Portable fluorescence immunity analysis instrument of the present invention is described in detail with reference to specific embodiment：
As shown in the analytical instrument functional block diagram of Fig. 1, the present invention includes alanine aminotransferase detection module 817, blood
Lactoferrin detection module 806, Blood grouping module 812, four detection modules 811 of fluorescence infectious disease, display screen 800, centre
Reason device (i.e. master control borad 818), motion, printer 803, data memory module 810, PS2 scanner interfaces 808 and USB connect
Several parts compositions such as mouth 807.Wherein hemoglobin detection module 806, alanine aminotransferase detection module 817, blood group inspection
Survey concentration of the module 812 using spectrophotometry measured matter；Four detection modules 811 of fluorescence infectious disease are anti-using photoelectricity
Penetrate photometry principle detection measured object concentration.
As shown in Fig. 3~10, the portable blood fluorescence immunity analyzer that the present invention designs, including testing agency, master control
Plate 818, data memory module 810 and the detection Kato disk 804 for transmitting microscope carrier portable blood detection and analysis card 805, institute
The testing agency stated includes alanine aminotransferase detection module 817, four detection modules 811 of fluorescence infectious disease, blood group inspection
Survey module 812 and hemoglobin detection module 806；
The hemoglobin detection module 806 is fixed on the bottom of the detection Kato disk 804, the detection Kato disk
804 lower section is also equipped with warm bath module 825, and the detection Kato disk 804 is erected on bottom plate 823 and passes through driving device
Its disengaging movement of I driving；The driving device I includes direct current generator 822 and screw rod, and the direct current generator 822 passes through spiral shell
The bar connection detection Kato disk 804, the direct current generator 822 drive the disengaging campaign of the detection Kato disk 804.Institute
The detection Kato disk 804 stated is erected at by two support shafts 824 being set up in parallel on bottom plate 823, and the two of the support shaft 824
End is separately fixed on the bottom plate 823.
Guide rail 816, the alanine aminotransferase detection module are vertically installed on the bottom plate 823
817 are assemblied in by structure stand 813 on the sliding block of the guide rail 816, and the alanine is driven by driving device II
Aminopherase detection module 817 moves up and down in the top of the detection Kato disk 804；The driving device II is step
Stepper motor 815, the stepper motor 815 are fixedly mounted on the vertical connecting plate 820-1 of the fixed plate 820.The instrument
In, transmission microscope carrier of the detection Kato disk 804 for portable blood detection and analysis card 805.
The Blood grouping module 812 is installed on the module installing zone 819-2 of structural member holder 819, the structure
The fluorescence excitation that backlight 821 is also equipped on the backlight installing zone 819-1 of part holder 819 for four detections of infectious disease shines
It penetrates, the structural member holder 819 is fixedly installed in lower section (the Blood grouping module 812 and the backlight of fixed plate 820
821 between structural member holder 819 and fixed plate 820), described four detection modules 811 of fluorescence infectious disease are fixedly mounted
In the top of the fixed plate 820, four detection modules 811 of the fluorescence infectious disease are fixed in the master control borad 818 stacking
Top；
The fixed plate 820 is fixed on by stud 826 on the bottom plate 823；
Data memory module 810, the warm bath module 825 and each module of the testing agency passes through
The FPC lines connection master control borad 818.
As a kind of optimal technical scheme, it is provided with shell 802 outside the Portable fluorescence immunity analysis instrument, it is described
Shell 802 divides for upper shell 802-2 and lower housing 802-8.The bottom plate 823 is fixedly mounted on the lower housing 802-8
On, the data memory module 810 is fixed on the panel-mounted position 802-5 of the upper shell 802-2.The analyzer also wraps
Include printer 803, display screen 800, key panel 801, power interface 809, PS2 scanner interfaces 808 and USB interface 807.Institute
The printer 803 stated is installed on the printer assembly position of the upper shell 802-2 and is connected to interface board 814 by FPC lines,
The interface board 814 is installed on the lower housing；The display screen 800 is installed among the upper shell 802-2
In the display window of position, and master control borad 818 is connected to by FPC lines；The key panel 801 is installed on the upper shell
The button installation position of 802-2 is simultaneously connected to master control borad 818 by FPC lines.
The power interface 809 is inputted for working power and reserve battery charging, the reserve battery are assemblied in
In the battery settling groove of lower housing 802-8.
The printer 803 is preferably thermal printer as data-printing output equipment.800 conduct of the display screen
Presentation of information, indicating equipment.The human-computer interaction device that the key panel 801 sets or selects as function.The PS2 scannings
Instrument interface 808 is used as bar code scanner input equipment.The USB interface 807 is as USB principal and subordinate links equipment, it can be achieved that data
Storage, data-transformation facility.The power interface 809 charges for power work power input and reserve battery.The number
It is preferably input of the RFID module for detecting the information such as card batch, parameter, and its detection data after test according to memory module 810
Preservation.Up and down motion of the guide rail 816 for alanine aminotransferase detection module 817 is oriented to.The stepper motor
815 for driving alanine aminotransferase detection module 817 to move up and down.The master control borad 818 is assisted for Comprehensive Control
The normal work of each electric component inside demodulating apparatus.
The compact arrangement for the portable blood fluorescence immunity analyzer that the present invention designs has splendid shock resistance effect, letter
Appearance about and key arrangement, also allow operation more succinctly with intuitively.Modules group as structure can be in related market
Upper directly to purchase, assembly material facilitates acquisition.
Each component assembling process of Portable fluorescence immunity analysis instrument of the present invention is as described below：
The built-in printer 803 is fixed by 4 screws, is installed on the printer assembly of 802 upper shell 802-2 of shell
Position 802-3 is connected to interface board 814 by FPC lines.Liquid crystal display 800 is fixed by two screws, is installed on shell
802-1 in the display window in 802 centre positions upper shell 802-2, master control borad 818 is connected to by FPC lines.Key panel 801
It is affixed on key panel by 3M gluings and assembles position 802-4, master control borad 818 is connected to by FPC lines.Data memory module
(RFID module) 810 is affixed on the memory module panel-mounted position 802-5 of upper shell 802-2 by 3M gluings, is connected by FPC lines
It is connected to master control borad 818.
The alanine aminotransferase detection module 817 by structure stand 813 be assemblied in guide rail 816 sliding block it
On, it is moved up and down by the driving of stepper motor 815.Alanine aminotransferase detection module 817 is connected to by FPC leads
Master control borad 818 is used as data acquisition and control.
The Blood grouping module 812 is installed on the inspection that blood group is used on the module installing zone 819-2 of structural member holder 819
It surveys and data acquires.Backlight 821 is installed on the backlight installing zone 819-1 of structural member holder 819 upper for infectious disease four
Item fluorescence-exciting radiation.
The structural member holder 819 is screwed in 820 lower section of fixed plate.Four detection modules of fluorescence infectious disease
811 are screwed above fixed plate 820.Master control borad 818 is fixed on four detections of fluorescence infectious disease by screw stacking
811 top of module.
The stepper motor 815 is screwed at fixed plate 820-1.
The hemoglobin detection module 806 and warm bath module 825 are screwed on pallet 804.
The pallet 804 is set up in by support shaft 824 on bottom plate 823, and direct current generator 822 passes through screw rod connecting trays
804, direct current generator 822 drives pallet disengaging movement.
The fixed plate 820 is fixed on by stud 826 on bottom plate 823.
The bottom plate 823 is screwed on lower housing 802-8, and interface board 814 is screwed in lower housing
Interface board installation position 802-7 on.
The reserve battery is assemblied in the battery case 802-6 of lower housing, is fixed by battery cover and screw hole.
As shown in Fig. 2, the workflow of the analyzer is：
After instrument booting, self-test is carried out to internal each function module, and carries out 37 DEG C of constant temperature incubation environment constructions, about 2 points
Enter ready state after clock, waits for user's operation.Instrument starts to complete projects test, test after user is put into card to be measured
Each detection project result of automatic printing after the completion.
Detection prepares：
1, combine detection card is put under instrument ready state.
2, the blood sample amount of respective item is added in each sample well of composite card.
3, it respectively assists that appropriate auxiliary liquid is added in liquid well in composite card.
4, after completing above step, confirm, instrument sequentially starts to detect.
Detection ordering：
According to the reaction time demand of projects, instrument be successively read hemoglobin, alanine aminotransferase, blood group,
Infectious disease four.It is 10 minutes to complete the single deck tape-recorder whole item detection time.
Record：
1, instrument is equipped with a record storage area, and test record automatically saves, and user is facilitated to check record at any time.
Whether 2, thermal printer built in instrument, user can be printed with unrestricted choice data.
Portable blood fluorescence immunity analyzer process for using：
Instrument power source is opened, after instrument is ready, detection Kato disk 804 stretches out, and is put into detection card 805, sample is added
And flushing liquor, according to screen prompt, 801 corresponding function button of key panel, detection Kato disk 804 enters instrument internal with card,
Instrument is successively read hemoglobin, alanine aminotransferase, blood group, infectious disease four.When completing single deck tape-recorder whole item detection
Between be 10 minutes.Instrument shows result liquor charging crystal display screen 800 after the completion of detection, and is printed by built-in printer 803 defeated
Go out.Detection Kato disk 804 stretches out again, takes useless card away at this time, is put into new detection card 805 and carries out next round test.
Alanine aminotransferase detection module, hemoglobin used in the portable blood fluorescence immunity analyzer
Detection module, Blood grouping module, four detection modules of fluorescence infectious disease and warm bath module those skilled in the art can lead to
Cross conventional means acquisition.
Such as Figure 11~12, the warm bath module is divided into the top part and the bottom part a point composition, and wherein top half and alanine amino turns
It moves enzyme detection module to be integrated in one, by ceramic heating flake (model：P1010, Zhuhai Hui You Electronics Co., Ltd.s), temperature sensing
Device (model IT503F-3950A-L240, Guangdong Ai Sheng Electronic Science and Technology Co., Ltd.s), structural member 827 and PCBA component assembly groups
At；Wherein ceramic heating flake is assemblied in the positions 827-3 of structural member, and PCBA components are assemblied in the regions 827-4, temperature sensor dress
Assigned in the positions 827-2；827-1 is that the optical detection on structural member passes in and out light window.Warm bath sensor lower half portion is by ceramics
Heating plate (model：P1010, Zhuhai Hui You Electronics Co., Ltd.s), temperature sensor (model IT503F-3950A-L240, Guangdong
Ai Sheng Electronic Science and Technology Co., Ltd.s) and structural member 828 form, wherein 828-1 be temperature sensor rigging position, 828-2 be pottery
Porcelain heating plate rigging position.
Hemoglobin detection module is made of shell and PCBA components, and PCBA components are assemblied on detection Kato disk 804,
Again fixation is covered with shell.
Four detection modules of fluorescence infectious disease are by critical piece CMOS line array sensors S12443 (shore pine photon), structure
Part, PCBA detection plates and PCBA backlights composition, CMOS line array sensors S12443 (shore pine photon), which is assemblied on pcb board, to be formed
PCBA detection plates, PCBA detection plates and PCBA backlights are assemblied in composition fluorescence four detection modules of infectious disease on structural member.
Four detection modules of Blood grouping module and fluorescence infectious disease are integrated on structural member, and by independent PCBA optics
Detection plate is composed.The module installing zone 819-2 that PCBA optical detection plates are assemblied in structural member holder 819 constitutes Blood grouping
Module.
2 portable blood of embodiment detection and analysis card
Portable blood detection and analysis card can use conduct after also decomposable asymmetric choice net as multinomial comprehensive detection reagent mode card
Individual event detection reagent mode card uses, the male and female that each single deck tape-recorder of individual event detection reagent mode card is identified by Figure 14 (round frame)
Knot that can be undone by a pull is connected, and the multinomial comprehensive detection reagent mode card of Figure 13 is combined into.
Portable blood detection and analysis card can be analyzed to four independent individual event detection reagent cards：Blood grouping reagent card 1,
Four detection reagent cards 2 of infectious disease, 4 four parts of ALT detection reagents card 3 and hemoglobin detection reagent card.Above-mentioned four
Individual event detection reagent card is secondary successively to be combined splicing by male knot that can be undone by a pull 5 and female knot that can be undone by a pull 6, and the bottom of each reagent card is respectively equipped with plate
Rib 7 is for positioning.
As shown in figure 15, Blood grouping reagent card 1 divides for 103 3 upper cover 101, pedestal 102 and Blood grouping strip portions
Point, upper cover 101 can be closely chimeric at an entirety by plate muscle column with pedestal 102, and the Blood grouping strip 103 is placed
In the card slot of pedestal 102, the upper cover 101 is equipped with location hole 101-1 and blood group well 101-2, the blood group
Well 101-2 corresponds to the blood group sample application zone of Blood grouping strip 103；There is positioning plate rib 7 on the pedestal 102, is used for
Location reagent is stuck in the placement location on portable blood fluorescence immunity analyzer.
The Blood grouping strip 103 is using diafiltration and chromatography compages, and structure is as shown in figure 16, lowest level base
Plate 103-1 is polyester fiber board, and layer is overlapped III 103-2 of blotting paper, II 103-3 of blotting paper, blotting paper I successively as shown on it
103-4, cushion pad 103-5, antibody pad 103-6.Antibody pads 103-6 and cushion pad 103-5 laps constitute blood group sample application zone,
It is corresponding with the blood group well 101-2 of Figure 15.Sample contacts after being added with antibody pad 103-6, and auxiliary liquid is added later and assists sample
This is percolated from top to bottom, and II 103-3 of blotting paper drains the liquid of diafiltration by chromatography scheme, and III 103-2 of blotting paper is then
Further by surplus liquid diafiltration drainage and toward reversed chromatography, liquid accumulator is prevented, reaction is promoted to be normally carried out.
As shown in figure 17, four detection reagent cards 2 of the infectious disease divide for upper cover 201, pedestal 202 and infectious disease four
203 3 parts of strip are detected, upper cover 201 can be closely chimeric at an entirety, infectious disease four by plate muscle column with pedestal 202
Item detection strip 203 is arranged in 202 corresponding card slot of the pedestal, and upper cover 201 is equipped with observation window 201-1, label window
Mouth 201-2, sample application hole 201-3, chromatography auxiliary liquid well 201-4, observation window 201-1 correspond to four detections of infectious disease
NC film 203-3, sample application hole 201-3 and chromatography auxiliary liquid well 201-4 in strip 203 correspond to infectious disease four respectively
The sample application zone in strip 203 and chromatography auxiliary liquid sample application zone are detected, has positioning plate rib 7 on pedestal 202, is used for location reagent card
Placement location on portable blood fluorescence immunity analyzer.
The fluorescence immune chromatography method that described four detection strips 203 of infectious disease use, foundation structure is as shown in figure 18, from
Glass pad 203-1, antibody pad 203-2, NC film 203-3 and substrate 203-4 are disposed under above, the glass pads 203-1
One end and one end of antibody pad 203-2 partly overlap, the other end and the NC films 203-3 of antibody pad 203-2
One end partly overlap, the other end of the NC films 203-3 is partially covered with blotting paper 203-5；The sample application zone is located at institute
The top for stating glass pad 203-1 pads the part of 203-2 close to antibody, and chromatography auxiliary liquid sample application zone is located at the sample-adding
Area is down at 4mm.Four detection strips 203 of infectious disease are tied using polyester sheet as substrate 203-4 using the basis of general chromatography
Structure, the albumen of fluorescence signal is marked in coating on antibody pad 203-2, and immune cross-linking reaction, NC are carried out with target detection albumen
Test lines and control lines are coated on film 203-3, as test and quality control index.
As shown in figure 19, the ALT detection reagents card 3 divides for upper cover 301, pedestal 302 and ALT detection strips 303 3
A part, the upper cover 301 and pedestal 302 can closely be fitted into an entirety by plate muscle column, and ALT detects strip 303
It is placed in 302 corresponding card slot of pedestal, there is ALT detection window 301-1 in upper cover 301, for exempting from portable blood fluorescence
Epidemic disease analyzer is used cooperatively, and additions of the ALT wells 301-2 for detecting sample is additionally provided in upper cover 301, is gone back in upper cover 301
Equipped with anchor point 301-3, cooperation detection is stuck in the positioning in portable blood fluorescence immunity analyzer.It opens at the back side of pedestal 302
There are bottoming hole 302-1, cooperation portable blood fluorescence immunity analyzer to detect the heat effect of strip 303 to ALT.
As shown in figure 20, the hemoglobin detection reagent card 4 divides for upper cover 401, pedestal 402 and Hb detection strips
403 3 parts, upper cover 401 and pedestal 402 can closely be fitted into an entirety by plate muscle column, and Hb detections strip 403 is put
It sets in 402 corresponding card slot of pedestal, there is hemoglobin well 401-1, the addition for detecting sample in upper cover 401.Bottom
402 back sides of seat are provided with hemoglobin loophole 402-1, and cooperation portable blood fluorescence immunity analyzer is to hemoglobin detection
Mesh carries out digital independent.
The Blood grouping reagent card 1, four detection reagent cards 2 of infectious disease, ALT detection reagents card 3, hemoglobin inspection
4 tetrameric detection reagent card of test agent card can be combined by male knot that can be undone by a pull 5 and female knot that can be undone by a pull 6, be spliced into
Integrated combine detection reagent card.The tetrameric back side is distributed with positioning plate rib 7, for coordinating detection reagent to be stuck in just
The placement positioning inside formula Blood fluorescence immunity analysis instrument is taken, portable blood tests and analyzes card back structures figure such as Figure 21 institutes
Show.
The detection card of the present invention realizes multinomial blood screening safety detection, can independently select individual event mesh, entry group
Close the portable blood detection and analysis card of comprehensive detection；Portable blood fluorescence immunity analyzer coordinates portable blood detection point
Analysis card use, for controlling detection reaction condition, testing result interpretation processing, Analysis of test results, testing result, which exports, to be preserved,
Portable blood fluorescence immunity analyzer can coordinate the portable blood detection and analysis card of various combinations to be detected.
Claims (9)
1. a kind of portable blood fluorescence immunity analyzer, which is characterized in that the analyzer includes testing agency, master control borad
(818), data memory module (810) and the detection Kato disk (804) for transmitting microscope carrier detection card, testing agency packet
Include alanine aminotransferase detection module (817), four detection modules (811) of fluorescence infectious disease, Blood grouping module (812)
With hemoglobin detection module (806)；
The hemoglobin detection module (806) is fixed on the bottom of the detection Kato disk (804), the detection Kato disk
(804) warm bath module (825) is also equipped with below, the detection Kato disk (804) is erected on bottom plate (823) and passes through
Driving device I drives its disengaging movement；
Guide rail (816), the alanine aminotransferase detection module are vertically installed on the bottom plate (823)
(817) it is assemblied on the sliding block of the guide rail (816), is driven by driving device II described by structure stand (813)
Alanine aminotransferase detection module (817) moves up and down above the detection Kato disk (804)；
The Blood grouping module (812) is installed on the module installing zone (819-2) of structural member holder (819), the knot
Backlight (821) is also equipped on the backlight installing zone (819-1) of component holder (819) for the glimmering of four detections of infectious disease
Light exciting irradiation, the structural member holder (819) are fixedly installed in the lower section of fixed plate (820), the fluorescence infectious disease
Four detection modules (811) are fixedly installed in the top of the fixed plate (820), and the master control borad (818) stacking is fixed on
The top of four detection modules (811) of the fluorescence infectious disease；
The fixed plate (820) is fixed on by stud (826) on the bottom plate (823)；
Data memory module (810), the warm bath module (825) and each module of the testing agency passes through
The FPC lines connection master control borad (818).
2. portable blood fluorescence immunity analyzer according to claim 1, which is characterized in that the portable blood
It is provided with shell (802) outside fluorescence immunity analyzer, the shell (802) is divided into upper shell (802-2) and lower housing (802-
8)。
3. portable blood fluorescence immunity analyzer according to claim 2, which is characterized in that the bottom plate (823)
It is fixedly mounted on the lower housing (802-8), the data memory module (810) is fixed on the upper shell (802-
2) panel-mounted position (802-5).
4. portable blood fluorescence immunity analyzer according to claim 1 or 2, which is characterized in that the analyzer also wraps
Include printer (803), display screen (800), key panel (801), power interface (809), PS2 scanner interfaces (808) and USB
At least one of interface (807) component.
5. portable blood fluorescence immunity analyzer according to claim 4, which is characterized in that the printer
(803) it is installed on the printer assembly position of the upper shell (802-2) and interface board (814) is connected to by FPC lines, it is described
Interface board (814) be installed on the lower housing；The display screen (800) is installed in the upper shell (802-2)
Between position display window in, and master control borad (818) is connected to by FPC lines；The key panel (801) is installed on described
The button installation position of upper shell (802-2) is simultaneously connected to master control borad (818) by FPC lines.
6. portable blood fluorescence immunity analyzer according to claim 4, which is characterized in that the power interface
(809) it is used for working power input and reserve battery charging, the reserve battery to be assemblied in the battery peace of lower housing (802-8)
In tankage.
7. the portable blood fluorescence immunity analyzer stated according to claim 1, which is characterized in that the driving device I is wrapped
Direct current generator (822) and screw rod are included, the direct current generator (822) passes through the screw rod connection detection Kato disk (804), institute
The disengaging campaign for direct current generator (822) the driving detection Kato disk (804) stated.
8. the portable blood fluorescence immunity analyzer stated according to claim 1, which is characterized in that the detection Kato disk
(804) it is erected on bottom plate (823) by two support shafts (824) being set up in parallel, the both ends difference of the support shaft (824)
It is fixed on the bottom plate (823).
9. the portable blood fluorescence immunity analyzer stated according to claim 1, which is characterized in that the driving device II is
Stepper motor (815), the stepper motor (815) are fixedly mounted on the vertical connecting plate (820-1) of the fixed plate (820)
On.
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| CN110736845A (en) * | 2019-10-31 | 2020-01-31 | 深圳福能医疗科技有限公司 | detection device for glycosylated hemoglobin and detection method thereof |
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