CN108348479A - 靶向甲酰肽受体2/脂氧素a4受体(fpr2/alx)以用于治疗心脏疾病 - Google Patents

靶向甲酰肽受体2/脂氧素a4受体(fpr2/alx)以用于治疗心脏疾病 Download PDF

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Publication number
CN108348479A
CN108348479A CN201680068442.7A CN201680068442A CN108348479A CN 108348479 A CN108348479 A CN 108348479A CN 201680068442 A CN201680068442 A CN 201680068442A CN 108348479 A CN108348479 A CN 108348479A
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CN
China
Prior art keywords
alx
fpr2
treatment
receptor
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201680068442.7A
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English (en)
Chinese (zh)
Inventor
J.奥斯特罗夫斯基
R.加西亚
N.R.维尔茨
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of CN108348479A publication Critical patent/CN108348479A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4152—1,2-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. antipyrine, phenylbutazone, sulfinpyrazone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201680068442.7A 2015-11-24 2016-11-21 靶向甲酰肽受体2/脂氧素a4受体(fpr2/alx)以用于治疗心脏疾病 Pending CN108348479A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562259498P 2015-11-24 2015-11-24
US62/259498 2015-11-24
PCT/US2016/063036 WO2017091496A1 (en) 2015-11-24 2016-11-21 Targeting of the formyl-peptide receptor 2/lipoxin a4 receptor (fpr2/alx) for treatment of heart disease

Publications (1)

Publication Number Publication Date
CN108348479A true CN108348479A (zh) 2018-07-31

Family

ID=57544530

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201680068442.7A Pending CN108348479A (zh) 2015-11-24 2016-11-21 靶向甲酰肽受体2/脂氧素a4受体(fpr2/alx)以用于治疗心脏疾病

Country Status (13)

Country Link
US (1) US20180325869A1 (enExample)
EP (1) EP3380091A1 (enExample)
JP (1) JP2018538367A (enExample)
KR (1) KR20180081528A (enExample)
CN (1) CN108348479A (enExample)
AU (1) AU2016359463A1 (enExample)
BR (1) BR112018010155A8 (enExample)
CA (1) CA3006291A1 (enExample)
EA (1) EA201891007A1 (enExample)
IL (1) IL259468A (enExample)
MX (1) MX2018005756A (enExample)
SG (1) SG11201803816RA (enExample)
WO (1) WO2017091496A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10717708B2 (en) 2015-12-10 2020-07-21 Bristol-Myers Squibb Company Piperidinone formyl peptide 2 receptor and formyl peptide 1 receptor agonists
WO2018227065A1 (en) 2017-06-09 2018-12-13 Bristol-Myers Squibb Company Piperidinone formyl peptide 2 receptor and formyl peptide 1 receptor agonists
ES2869129T3 (es) * 2017-06-09 2021-10-25 Bristol Myers Squibb Co Agonistas de piperidinona del receptor 2 de péptidos formilados
US11180490B2 (en) 2017-06-09 2021-11-23 Bristol-Myers Squibb Company Cyclopropyl urea formyl peptide 2 receptor and formyl peptide 1 receptor agonists
CN110997653B (zh) 2017-06-09 2023-06-06 百时美施贵宝公司 芳基杂环哌啶酮甲酰肽2受体和甲酰肽1受体激动剂
KR102803660B1 (ko) 2018-03-05 2025-05-02 브리스톨-마이어스 스큅 컴퍼니 페닐피롤리디논 포르밀 펩티드 2 수용체 효능제
US12281108B2 (en) 2018-11-26 2025-04-22 Bristol-Myers Squibb Company Pyrrolidinone derivatives as formyl peptide 2 receptor agonists

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103221392A (zh) * 2010-11-17 2013-07-24 埃科特莱茵药品有限公司 桥联螺[2.4]庚酯衍生物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0821115A8 (pt) * 2007-12-18 2017-12-26 Actelion Pharmaceuticals Ltd Composto derivado de aminotriazol, medicamento, composição farmacêutica e uso do composto
US9284288B2 (en) * 2012-05-16 2016-03-15 Actelion Pharmaceuticals Ltd. 1-(p-tolyl) cyclopropyl substituted bridged spiro[2.4]heptane derivatives as ALX receptor agonists
US10717708B2 (en) * 2015-12-10 2020-07-21 Bristol-Myers Squibb Company Piperidinone formyl peptide 2 receptor and formyl peptide 1 receptor agonists
KR102803660B1 (ko) * 2018-03-05 2025-05-02 브리스톨-마이어스 스큅 컴퍼니 페닐피롤리디논 포르밀 펩티드 2 수용체 효능제

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103221392A (zh) * 2010-11-17 2013-07-24 埃科特莱茵药品有限公司 桥联螺[2.4]庚酯衍生物

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
CHENGXUE QIN, ET AL.: "Cardioprotective potential of annexin-A1 mimetics in myocardial infarction", 《PHARMACOLOGY & THERAPEUTICS》 *
HUAMEI FORSMAN, ET AL.: "Stable formyl peptide receptor agonists that activate the neutrophil NADPH-oxidase identified through screening of a compound library", 《BIOCHEMICAL PHARMACOLOGY》 *
JESMOND DALLI, ET AL.: "Proresolving and Tissue-Protective Actions of Annexin A1–Based Cleavage-Resistant Peptides Are Mediated by Formyl Peptide Receptor 2/Lipoxin A4 Receptor", 《THE JOURNAL OF IMMUNOLOGY》 *
MARCELO H. PETRI , ET AL.: "The role of the FPR2/ALX receptor in atherosclerosis development and plaque stability", 《CARDIOVASCULAR RESEARCH》 *
THOMAS GOBBETTI, ET AL.: "Nonredundant protective properties of FPR2/ALX in polymicrobial murine sepsis", 《PNAS》 *
VASUNDHARA KAIN, ET AL.: "Resolvin D1 activates the inflammation resolving response at splenic and ventricular site following myocardial infarction leading to improved ventricular function", 《JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY》 *

Also Published As

Publication number Publication date
EA201891007A1 (ru) 2018-11-30
CA3006291A1 (en) 2017-06-01
EP3380091A1 (en) 2018-10-03
IL259468A (en) 2018-07-31
MX2018005756A (es) 2018-08-01
US20180325869A1 (en) 2018-11-15
AU2016359463A1 (en) 2018-07-12
KR20180081528A (ko) 2018-07-16
BR112018010155A8 (pt) 2019-02-26
SG11201803816RA (en) 2018-06-28
JP2018538367A (ja) 2018-12-27
BR112018010155A2 (pt) 2018-11-21
WO2017091496A1 (en) 2017-06-01

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Application publication date: 20180731