CN108324912A - 一种用于治疗口腔溃疡的复合膜剂及其制备方法 - Google Patents

一种用于治疗口腔溃疡的复合膜剂及其制备方法 Download PDF

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CN108324912A
CN108324912A CN201810353808.6A CN201810353808A CN108324912A CN 108324912 A CN108324912 A CN 108324912A CN 201810353808 A CN201810353808 A CN 201810353808A CN 108324912 A CN108324912 A CN 108324912A
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essential oil
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谢海青
谢君毅
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Foshan University
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Abstract

本发明公开了一种用于治疗口腔溃疡的复合膜剂，其由复方中草药膜层和位于该复方中草药膜层上层的精油膜层复合而成。本发明采用中草药膜层与精油膜层复合，使该膜剂对口腔溃疡局部兼具前期治疗和后期修复的功效。本发明还公开了该复合膜剂的制备方法，其工艺简单，有利于大规模工业化生产。

Description

一种用于治疗口腔溃疡的复合膜剂及其制备方法
技术领域
本发明涉及口腔医学领域，特别涉及一种复合膜剂。
背景技术
对于口腔溃疡现有的治疗方法分为局部用药和内服药，其中局部用药的产品具有多样化，包括喷雾、贴膜、粉剂等，其中口腔贴膜因其具有药效作用时间较长、口腔不适感较低、用药部位较精准等优点而越来越受到患者的青睐。然而，现有的口腔贴膜治疗药效仍有待提高，且其药效较单一，没有较好的后期修复作用。
发明内容
本发明的目的在于针对上述现有技术的不足，提供一种用于治疗口腔溃疡的复合膜剂，同时提供该复合膜剂的制备方法。
本发明所采取的技术方案是：一种用于治疗口腔溃疡的复合膜剂，其由复方中草药膜层和位于该复方中草药膜层上层的精油膜层复合而成。
作为上述方案的进一步改进，所述复方中草药膜层按原料重量份计包括壳聚糖50～80份、维生素1～3份和中草药复合物10～30份。
具体地，本发明用壳聚糖作为复方中草药膜层的成膜物质，其对维生素和中草药复合物具有优异的分散性能，同时可提高维生素和中草药复合物的被吸收能力。
作为上述方案的进一步改进，所述中草药复合物由白芨、黄柏、干姜、田七、芦荟按原料重量份比为1:1:1:1:1组成。具体地，本发明该中草药复合物针对口腔溃疡具有药效显著、低毒性、易吸收的特点。
作为上述方案的进一步改进，所述精油膜层按原料重量份计包括鱼鳔胶15～20份、薄荷脑1～3份、绿茶粉0.2～0.5份和复方精油5～8份。
具体地，本发明用鱼鳔胶作为精油膜层的成膜物质，其亦是复方精油优良的载体，且其本身具有解毒敛疮、促进溃疡愈合之功效，使得该复合膜剂具有显著的后期修复功效。
作为上述方案的进一步改进，所述复方精油为花香类精油与叶片类精油按原料重量份比为5:1组成。具体地，花香类精油具有较为显著的修护功效，而叶片类精油则消炎杀毒功效显著，两者按一定比例复合，相辅相成，进一步提高其对口腔溃疡的后期修复作用。
作为上述方案的进一步改进，所述花香类精油选自洋甘菊精油、玫瑰精油、茉莉精油、橙花精油、金银花精油、薰衣草精油、紫罗兰精油中的至少一种。
作为上述方案的进一步改进，所述叶片类精油选自茶树精油、留兰香精油、广藿香精油、薄荷精油、松针精油中的至少一种。
一种如上所述的用于治疗口腔溃疡的复合膜剂的制备方法，其包括如下工艺步骤：
1)按原料重量份计将中草药复合物各组分研磨成粉后混合均匀，加水煎煮提取2次，合并两次滤液，浓缩至10～15g/ml，备用；
2)将复方中草药膜层的各原料组分溶于浓度为1％的冰醋酸水溶液中，待溶胀后，得混合胶浆，备用；
3)按原料重量份计将精油膜层各原料组分与有机酸水溶液混合，在室温下进行磁力搅拌溶解，得混合溶液，备用；
4)取步骤2)所得混合胶浆流延制得中草药膜层，再采用流延法在中草药膜层上制备得精油膜层，干燥，得成品。
作为上述方案的进一步改进，步骤4)所述中草药膜层的厚度为0.3～0.8mm。
作为上述方案的进一步改进，步骤4)所述精油膜层的厚度为0.1～0.3mm。
本发明的有益效果是：
本发明采用中草药膜层与精油膜层复合，使该膜剂对口腔溃疡局部兼具前期治疗和后期修复的功效。
本发明的制备方法工艺简单，有利于大规模工业化生产。
具体实施方式
下面结合实施例对本发明进行具体描述，以便于所属技术领域的人员对本发明的理解。有必要在此特别指出的是，实施例只是用于对本发明做进一步说明，不能理解为对本发明保护范围的限制，所属领域技术熟练人员，根据上述发明内容对本发明作出的非本质性的改进和调整，应仍属于本发明的保护范围。同时下述所提及的原料未详细说明的，均为市售产品；未详细提及的工艺步骤或制备方法为均为本领域技术人员所知晓的工艺步骤或制备方法。
实施例1
一种用于治疗口腔溃疡的复合膜剂，其由复方中草药膜层和位于该复方中草药膜层上层的精油膜层复合而成。
其中，所述复方中草药膜层按原料重量份计包括壳聚糖50份、维生素3份、白芨2份、黄柏2份、干姜2份、田七2份和芦荟2份。
所述精油膜层按原料重量份计包括鱼鳔胶15份、薄荷脑3份、绿茶粉0.2份和复方精油8份；所述复方精油为花香类精油与叶片类精油按原料重量份比为5:1组成，所述花香类精油为洋甘菊精油、玫瑰精油、茉莉精油和橙花精油的复合物；所述叶片类精油为茶树精油。制备方法：
1)按原料重量份计将中草药复合物各组分研磨成粉后混合均匀，加水煎煮提取2次，合并两次滤液，浓缩至10～15g/ml，备用；
2)将复方中草药膜层的各原料组分溶于浓度为1％的冰醋酸水溶液中，待溶胀后，得混合胶浆，备用；
3)按原料重量份计将精油膜层各原料组分与有机酸水溶液混合，在室温下进行磁力搅拌溶解，得混合溶液，备用；
4)取步骤2)所得混合胶浆流延制得厚度为0.3mm的中草药膜层，再采用流延法在中草药膜层上制备得厚度为0.3mm的精油膜层，干燥，得实施例1成品。
实施例2
一种用于治疗口腔溃疡的复合膜剂，其由复方中草药膜层和位于该复方中草药膜层上层的精油膜层复合而成。
其中，所述复方中草药膜层按原料重量份计包括壳聚糖80份、维生素1份、白芨6份、黄柏6份、干姜6份、田七6份和芦荟6份。
所述精油膜层按原料重量份计包括鱼鳔胶20份、薄荷脑1份、绿茶粉0.5份和复方精油5份；所述复方精油为花香类精油与叶片类精油按原料重量份比为5:1组成；所述花香类精油为紫罗兰精油；所述叶片类精油为留兰香精油、广藿香精油、薄荷精油和松针精油的复合物。
制备方法：
1)按原料重量份计将中草药复合物各组分研磨成粉后混合均匀，加水煎煮提取2次，合并两次滤液，浓缩至10～15g/ml，备用；
2)将复方中草药膜层的各原料组分溶于浓度为1％的冰醋酸水溶液中，待溶胀后，得混合胶浆，备用；
3)按原料重量份计将精油膜层各原料组分与有机酸水溶液混合，在室温下进行磁力搅拌溶解，得混合溶液，备用；
4)取步骤2)所得混合胶浆流延制得厚度为0.8mm的中草药膜层，再采用流延法在中草药膜层上制备得厚度为0.1mm的精油膜层，干燥，得实施例2成品。
实施例3
一种用于治疗口腔溃疡的复合膜剂，其由复方中草药膜层和位于该复方中草药膜层上层的精油膜层复合而成。
其中，所述复方中草药膜层按原料重量份计包括壳聚糖65份、维生素2份、白芨4份、黄柏4份、干姜4份、田七4份和芦荟4份。
所述精油膜层按原料重量份计包括鱼鳔胶18份、薄荷脑2份、绿茶粉0.3份和复方精油6份；所述复方精油为花香类精油与叶片类精油按原料重量份比为5:1组成；所述花香类精油为金银花精油和薰衣草精油的复合物；所述叶片类精油为广藿香精油和松针精油的复合物。
制备方法：
1)按原料重量份计将中草药复合物各组分研磨成粉后混合均匀，加水煎煮提取2次，合并两次滤液，浓缩至10～15g/ml，备用；
2)将复方中草药膜层的各原料组分溶于浓度为1％的冰醋酸水溶液中，待溶胀后，得混合胶浆，备用；
3)按原料重量份计将精油膜层各原料组分与有机酸水溶液混合，在室温下进行磁力搅拌溶解，得混合溶液，备用；
4)取步骤2)所得混合胶浆流延制得厚度为0.5mm的中草药膜层，再采用流延法在中草药膜层上制备得厚度为0.2mm的精油膜层，干燥，得实施例3成品。
上述实施例为本发明的优选实施例，凡与本发明类似的工艺及所作的等效变化，均应属于本发明的保护范畴。

Claims (10)

1.一种用于治疗口腔溃疡的复合膜剂，其特征在于：由复方中草药膜层和位于该复方中草药膜层上层的精油膜层复合而成。
2.根据权利要求1所述的一种用于治疗口腔溃疡的复合膜剂，其特征在于：所述复方中草药膜层按原料重量份计包括壳聚糖50～80份、维生素1～3份和中草药复合物10～30份。
3.根据权利要求2所述的一种用于治疗口腔溃疡的复合膜剂，其特征在于：所述中草药复合物由白芨、黄柏、干姜、田七、芦荟按原料重量份比为1:1:1:1:1组成。
4.根据权利要求1所述的一种用于治疗口腔溃疡的复合膜剂，其特征在于：所述精油膜层按原料重量份计包括鱼鳔胶15～20份、薄荷脑1～3份、绿茶粉0.2～0.5份和复方精油5～8份。
5.根据权利要求4所述的一种用于治疗口腔溃疡的复合膜剂，其特征在于：所述复方精油为花香类精油与叶片类精油按原料重量份比为5:1组成。
6.根据权利要求5所述的一种用于治疗口腔溃疡的复合膜剂，其特征在于：所述花香类精油选自洋甘菊精油、玫瑰精油、茉莉精油、橙花精油、金银花精油、薰衣草精油、紫罗兰精油中的至少一种。
7.根据权利要求5所述的一种用于治疗口腔溃疡的复合膜剂，其特征在于：所述叶片类精油选自茶树精油、留兰香精油、广藿香精油、薄荷精油、松针精油中的至少一种。
8.一种如权利要求1～7任一项所述的用于治疗口腔溃疡的复合膜剂的制备方法，其特征在于包括如下工艺步骤：
1)按原料重量份计将中草药复合物各组分研磨成粉后混合均匀，加水煎煮提取2次，合并两次滤液，浓缩至10～15g/ml，备用；
2)将复方中草药膜层的各原料组分溶于浓度为1％的冰醋酸水溶液中，待溶胀后，得混合胶浆，备用；
3)按原料重量份计将精油膜层各原料组分与有机酸水溶液混合，在室温下进行磁力搅拌溶解，得混合溶液，备用；
4)取步骤2)所得混合胶浆流延制得中草药膜层，再采用流延法在中草药膜层上制备得精油膜层，干燥，得成品。
9.根据权利要求8所述的一种用于治疗口腔溃疡的复合膜剂的制备方法，其特征在于：步骤4)所述中草药膜层的厚度为0.3～0.8mm。
10.根据权利要求8所述的一种用于治疗口腔溃疡的复合膜剂的制备方法，其特征在于：步骤4)所述精油膜层的厚度为0.1～0.3mm。
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