CN108315251A - A kind of strain fermentation control system - Google Patents
A kind of strain fermentation control system Download PDFInfo
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- CN108315251A CN108315251A CN201810240035.0A CN201810240035A CN108315251A CN 108315251 A CN108315251 A CN 108315251A CN 201810240035 A CN201810240035 A CN 201810240035A CN 108315251 A CN108315251 A CN 108315251A
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- 238000000855 fermentation Methods 0.000 title claims abstract description 251
- 230000004151 fermentation Effects 0.000 title claims abstract description 251
- 238000012544 monitoring process Methods 0.000 claims description 111
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 80
- 229910052760 oxygen Inorganic materials 0.000 claims description 80
- 239000001301 oxygen Substances 0.000 claims description 80
- 230000002572 peristaltic effect Effects 0.000 claims description 41
- 238000002156 mixing Methods 0.000 claims description 38
- 239000000523 sample Substances 0.000 claims description 38
- 239000006260 foam Substances 0.000 claims description 36
- 239000006052 feed supplement Substances 0.000 claims description 31
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 28
- 239000002518 antifoaming agent Substances 0.000 claims description 22
- 238000003756 stirring Methods 0.000 claims description 21
- 239000002253 acid Substances 0.000 claims description 18
- 239000003513 alkali Substances 0.000 claims description 18
- 230000008859 change Effects 0.000 claims description 18
- 238000004891 communication Methods 0.000 claims description 17
- 239000000654 additive Substances 0.000 claims description 14
- 230000000996 additive effect Effects 0.000 claims description 14
- 239000002994 raw material Substances 0.000 claims description 14
- 238000010438 heat treatment Methods 0.000 claims description 10
- 238000009530 blood pressure measurement Methods 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 6
- 238000003860 storage Methods 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 230000000694 effects Effects 0.000 description 3
- JEGUKCSWCFPDGT-UHFFFAOYSA-N h2o hydrate Chemical compound O.O JEGUKCSWCFPDGT-UHFFFAOYSA-N 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 230000009471 action Effects 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 238000009529 body temperature measurement Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000005304 joining Methods 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 210000003739 neck Anatomy 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
- C12M27/02—Stirrer or mobile mixing elements
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/02—Means for regulation, monitoring, measurement or control, e.g. flow regulation of foam
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- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
- C12M41/18—Heat exchange systems, e.g. heat jackets or outer envelopes
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- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/26—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pH
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- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
- C12M41/32—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of substances in solution
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- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
- C12M41/34—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of gas
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- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
- C12M41/36—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of biomass, e.g. colony counters or by turbidity measurements
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- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/40—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pressure
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- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/42—Means for regulation, monitoring, measurement or control, e.g. flow regulation of agitation speed
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- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/48—Automatic or computerized control
Abstract
The invention discloses a kind of strain fermentation control systems, it is related to technical field of biological fermentation, the present invention includes fermentation tank, controller and multiple fermentation parameter feedback control modules, the present invention is when in use, each fermentation parameter feedback control module will be acquired the parameters in fermentation tank and feed back to controller, controller is adjusted the parameters in fermentation tank to control fermentation parameter feedback control module according to obtained parameter, present invention flexible adjustment in application, each parameter feedback are independent and rapid.
Description
Technical field
The present invention relates to technical field of biological fermentation, specially a kind of strain fermentation control system.
Background technology
The level of microbial fermentation production depends primarily on the heredity and condition of culture of strain itself.In some fermentation necks
Domain, such as strain fermentation, to ensure the speed of growth and quality of strain, how optimum culture condition accurately controls fermentation parameter
System is the emphasis and hot spot of a research.Present automation fermentation control system mostly uses computer or PLC is controlled.When
When computerizeing control, because the stability of existing operating system there is a problem of certain, computer corruption is often encountered
Situation can influence the progress of fermenting experiment, and fermentation failure is directly resulted in when serious.When being controlled with PLC, each fermentation parameter
The inaccurate independence of control, PLC is programmed and requires high, and system complex.
Invention content
Present invention aims at above-mentioned problems are solved, the present invention provides a kind of strain fermentation control systems；It is answered
Used time can complete on-line data acquisition in time, and on line real time control is carried out according to the data acquired.
The purpose of the present invention is achieved through the following technical solutions：
A kind of strain fermentation control system, including fermentation tank further include controller and multiple fermentation parameter monitoring modules, institute
Controller is stated for controlling multiple fermentation parameter monitoring modules to adjust the fermentation parameter in fermentation tank.
Further, the controller is communicated by RS485 buses and fermentation parameter monitoring module to control in fermentation tank
Fermentation parameter, the fermentation parameter monitoring module include temperature monitoring module, PH monitoring modules, dissolved oxygen monitoring module, stirring
Speed monitoring module, Anti Foam Control module, control of additive raw material module, air mass flow monitoring module and tank press monitoring module；
The temperature monitoring module is for acquiring the temperature data in fermentation tank and feeding back to controller, while monitoring temperature
Module can control the temperature in fermentation tank；It is required if temperature data meets fermentation, controller is not given instruction；If temperature data
It does not meet fermentation to require, then controller controls temperature monitoring module to change the temperature in fermentation tank；
The PH monitoring modules are for acquiring the pH value in fermentation tank and feeding back to controller, while PH monitoring modules can
Control the pH value in fermentation tank；It is required if pH value meets fermentation, controller is not given instruction；If pH value does not meet fermentation and requires,
Then controller controls PH monitoring modules to change the pH value in fermentation tank；
The dissolved oxygen monitoring module is for acquiring the oxygen dissolving value in fermentation tank and feeding back to controller, while dissolved oxygen monitors mould
Block can control the oxygen dissolving value in fermentation tank；It is required if oxygen dissolving value meets fermentation, controller is not given instruction；If oxygen dissolving value is not inconsistent
It closes fermentation to require, then controller controls dissolved oxygen monitoring module to change the oxygen dissolving value in fermentation tank；
The mixing speed monitoring module is for acquiring the mixing speed data in fermentation tank and feeding back to controller, simultaneously
Mixing speed monitoring module can control the mixing speed in fermentation tank；If the fermentation of mixing speed data fit requires, control
Device is not given instruction；If mixing speed data do not meet fermentation and require, controller controls mixing speed monitoring module to change hair
Mixing speed in fermentation tank；
The Anti Foam Control module is for acquiring the foam volume in fermentation tank and feeding back to controller, while Anti Foam Control mould
Block can control the foam volume in fermentation tank；It is required if foam volume meets fermentation, controller is not given instruction；If foam volume is not inconsistent
It closes fermentation to require, then controller controls Anti Foam Control module to change the foam volume in fermentation tank；
The control of additive raw material module is used for carry out feed supplement in fermentation tank, and controller control control of additive raw material module is come to fermentation
Feed supplement in tank；
The air mass flow monitoring module is for the air mass flow during monitor fermentation and feeds back to controller, can
Control the dissolved oxygen amount of fermentation tank；
The tank pressure monitoring module is for acquiring the pressure values in fermentation tank and feeding back to controller, while tank pressure monitoring mould
Block can control the pressure values in fermentation tank；It is required if pressure values meet fermentation, controller is not given instruction；If pressure values are not inconsistent
It closes fermentation to require, then controller control tank presses monitoring module to change the pressure values in fermentation tank.
Further, the temperature monitoring module includes temp probe, boiler, cold water storage cistern, electrically heated rod and two temperature
Water pump is controlled, electrically heated rod is located in boiler, and hot water is generated for heating；The both ends of one temperature control water pump respectively with boiler and
Fermentation tank connects, and the both ends of another temperature control water pump are connect with cold water storage cistern and fermentation tank respectively；The temp probe stretches into fermentation
For acquiring the temperature data in fermentation tank in tank, temperature data is sent to controller, the control by RS485 bus communications
Device controls the start and stop of two temperature control water pumps to control the temperature in fermentation tank according to temperature data.
Further, the PH monitoring modules include PH probes, alkali liquid tank, acid solution tank, acid adding peristaltic pump and alkali are added to wriggle
Pump, wherein the both ends of alkali peristaltic pump is added to be connect respectively with alkali liquid tank and fermentation tank, the both ends of acid adding peristaltic pump respectively with acid solution tank
It is connected with fermentation tank, the PH probes are stretched into for acquiring the pH value in fermentation tank in fermentation tank, and pH value is logical by RS485 buses
News are sent to controller, and the controller controls the start and stop of acid adding plus alkali peristaltic pump to control according to the pH value received
PH value in fermentation tank.
Further, the dissolved oxygen monitoring module includes dissolved oxygen signal transmitting device and dissolved oxygen probe, and the dissolved oxygen probe will
Its signal detected is sent to dissolved oxygen signal transmitting device, and dissolved oxygen signal transmitting device converts the signal that dissolved oxygen probe is sent to can
Oxygen dissolving value is sent to controller, controller root by the practical oxygen dissolving value read, dissolved oxygen signal transmitting device by RS485 bus communications
Control instruction is sent to control in fermentation tank to air mass flow monitoring module and mixing speed monitoring module according to oxygen dissolving value
Oxygen dissolving value.
Further, the mixing speed monitoring module includes frequency converter and stirring motor, on the output end of stirring motor
Equipped with agitating paddle, the agitating paddle of the stirring motor is located inside fermentation tank, and frequency converter is logical by RS485 buses with controller
News, the frequency converter are connect with stirring motor, and the controller sends control instruction to control stirring motor to frequency converter
Mixing speed.
Further, the Anti Foam Control module includes that foam probe, defoaming peristaltic pump and defoaming flow container, the foam are visited
Head is inserted into from the top of fermentation tank in fermentation tank, and the defoaming peristaltic pump both ends are separately connected fermentation tank and defoaming flow container, defoaming
Filled with antifoaming agent in flow container, the signal that the controller is detected according to foam probe defoams the start and stop of peristaltic pump to control；Foam
Controller control defoaming wriggling pump startup when having excess foam in probe detection to fermentation tank, defoaming peristaltic pump will defoam in flow container
Antifoaming agent be pumped into fermentation tank to be defoamed.
Further, the control of additive raw material module includes feed supplement tank and feed supplement peristaltic pump, the both ends difference of feed supplement peristaltic pump
It is connected with fermentation tank in feed supplement tank, the controller requires the start and stop of control feed supplement peristaltic pump to carry out fermentation tank according to fermentation
Feed supplement.
Further, the air mass flow monitoring module includes air flow meter and air intake valve, and air intake valve is located at hair
Outside fermentation tank, the air flow meter both ends are separately connected air intake valve and fermentation tank, and air flow meter passes through RS485 with controller
Bus communication, the controller control air intake valve open degree to which control is passed through the size of air mass flow according to oxygen dissolving value.
Further, the tank pressure monitoring module includes tank pressure measurement sensor and drain tap, and the tank pressure, which measures, to be passed
The end of probe of sensor stretches into fermentation tank, and tank presses measurement sensor with controller by RS485 bus communications, and tank presses measurement sensor
Pressure values in fermentation tank are fed back into controller, the controller controls the opening and closing of drain tap to control according to pressure values
Pressure values in fermentation tank processed.
By using the present invention, following advantageous effect can be generated：The present invention includes fermentation tank, controller and multiple fermentations
Parameter monitoring module, in the use of the present invention, each fermentation parameter monitoring module will supervise the parameters in fermentation tank
Control and feed back to controller, controller according to obtained measured value come to each fermentation parameter monitoring module send out control instruction from
And realize the control to the parameters in fermentation tank.Present invention fermentation parameter in application can be supervised by corresponding fermentation parameter
Control module is flexibly controlled, and each fermentation parameter also feeds back to controller in real time, to realize controller to entire
The monitoring of fermentation process, and then ensure that fermentation process is accurate, reliably completes.
Description of the drawings
Attached drawing described herein is used for providing further understanding the embodiment of the present invention, constitutes one of the application
Point, do not constitute the restriction to the embodiment of the present invention.In the accompanying drawings：
Fig. 1 is the system construction drawing of the present invention.
Specific implementation mode
To make the objectives, technical solutions, and advantages of the present invention clearer, with reference to embodiment and attached drawing, to this
Invention is described in further detail, and exemplary embodiment of the invention and its explanation are only used for explaining the present invention, do not make
For limitation of the invention.
As shown in Figure 1, a kind of strain fermentation control system, including fermentation tank, further include controller and various fermentation parameters
Monitoring module, controller is for controlling fermentation parameter monitoring module to adjust the fermentation parameter in fermentation tank；Preferably, controller
It is connect with each fermentation parameter monitoring module to control the fermentation parameter in fermentation tank by RS485 buses；Communications protocol uses
MODBUS-RTU；Fermentation parameter monitoring module includes temperature monitoring module, PH monitoring modules, dissolved oxygen monitoring module, mixing speed
Monitoring module, Anti Foam Control module, control of additive raw material module, air mass flow monitoring module and tank press monitoring module.
Specifically, controller communicates to control the fermentation in fermentation tank by RS485 buses and fermentation parameter monitoring module
Parameter；
Temperature monitoring module is for acquiring the temperature data in fermentation tank and feeding back to controller, while temperature monitoring module
The temperature in fermentation tank can be controlled；It is required if temperature data meets fermentation, controller is not given instruction；If temperature data is not inconsistent
It closes fermentation to require, then controller controls temperature monitoring module to change the temperature in fermentation tank；Correspondingly, temperature monitoring module packet
Temp probe, boiler, cold water storage cistern, electrically heated rod and two temperature control water pumps are included, electrically heated rod is located in boiler, for heating
Generate hot water；The both ends of one temperature control water pump are connect with boiler and fermentation tank respectively, the both ends difference of another temperature control water pump
It is connect with cold water storage cistern and fermentation tank；Temp probe stretches into fermentation tank for acquiring the temperature data in fermentation tank, temperature data
Be sent to controller by RS485 bus communications, controller according to temperature data come control the start and stop of two temperature control water pumps to
Control the temperature in fermentation tank.
PH monitoring modules are for acquiring the pH value in fermentation tank and feeding back to controller, while PH monitoring modules can control
PH value in fermentation tank；It is required if pH value meets fermentation, controller is not given instruction；If pH value does not meet fermentation and requires, control
Device processed controls PH monitoring modules to change the pH value in fermentation tank；Wherein, PH monitoring modules include PH probes, alkali liquid tank, acid solution
Tank, acid adding peristaltic pump and add alkali peristaltic pump, wherein add alkali peristaltic pump both ends connect respectively with alkali liquid tank and fermentation tank, acid adding is compacted
The both ends of dynamic pump are connect with acid solution tank and fermentation tank respectively, and PH probes are stretched into for acquiring the pH value in fermentation tank in fermentation tank,
PH probes use INPRO3030/120, PH probes that pH value is sent to PH signal transmitting devices again, and PH signal transmitting devices use
PH2050e transmitters；PH value is sent to controller by PH signal transmitting devices by RS485 bus communications, and controller is according to reception
To pH value come control acid adding, plus alkali peristaltic pump start and stop to control the pH value in fermentation tank.
Dissolved oxygen monitoring module is for acquiring the oxygen dissolving value in fermentation tank and feeding back to controller, while dissolved oxygen monitoring module energy
Enough control the oxygen dissolving value in fermentation tank；It is required if oxygen dissolving value meets fermentation, controller is not given instruction；If oxygen dissolving value does not meet hair
Ferment requires, then controller controls dissolved oxygen monitoring module to change the oxygen dissolving value in fermentation tank；Dissolved oxygen monitoring module includes dissolved oxygen letter
Number transmitter and dissolved oxygen probe, the signal that dissolved oxygen probe is detected are sent to dissolved oxygen signal transmitting device, dissolved oxygen signal transmitting
Device converts the signal that dissolved oxygen probe is sent to the practical oxygen dissolving value that can be read, and dissolved oxygen signal transmitting device is logical by RS485 buses
Oxygen dissolving value is sent to controller by news, and controller is according to oxygen dissolving value come to air mass flow monitoring module and mixing speed monitoring module
Control instruction is sent to control the oxygen dissolving value in fermentation tank；Specifically, dissolved oxygen probe uses INPRO6800/120 here, it is molten
Oxygen signal transmitter uses DO4050e transmitters
Mixing speed monitoring module stirs simultaneously for acquiring the mixing speed data in fermentation tank and feeding back to controller
Speed monitoring module can control the mixing speed in fermentation tank；If the fermentation of mixing speed data fit requires, controller is not
It gives instruction；If mixing speed data do not meet fermentation and require, controller controls mixing speed monitoring module to change fermentation tank
In mixing speed；Mixing speed monitoring module includes frequency converter and stirring motor, and frequency converter is using tricyclic SH-HVF II here
10K/600 types；The output end of stirring motor is equipped with agitating paddle, and the agitating paddle of stirring motor is located inside fermentation tank, frequency converter
With controller by RS485 bus communications, frequency converter is connect with stirring motor, controller to frequency converter send control instruction to
Control the mixing speed of stirring motor.
Anti Foam Control module is for acquiring the foam volume in fermentation tank and feeding back to controller, while Anti Foam Control module energy
Enough control the foam volume in fermentation tank；It is required if foam volume meets fermentation, controller is not given instruction；If foam volume does not meet hair
Ferment requires, then controller controls Anti Foam Control module to change the foam volume in fermentation tank；Anti Foam Control module includes that foam is visited
Head, defoaming peristaltic pump and defoaming flow container, foam probe are inserted into from the top of fermentation tank in fermentation tank, defoaming peristaltic pump both ends difference
Connect fermentation tank and defoaming flow container, filled with antifoaming agent in defoaming flow container, the signal that controller is detected according to foam probe controls
Defoam the start and stop of peristaltic pump；Foam probe detects in fermentation tank controller control defoaming wriggling pump startup when having excess foam,
The antifoaming agent defoamed in flow container is pumped into fermentation tank to defoam by defoaming peristaltic pump.Controller generally by level signal come
The start and stop of control defoaming peristaltic pump, the general state of the sent out signal of foam probe is if high level signal, when detecting foam
When foam probe level signal be converted into low level, after low level signal is sent to controller, controller will start defoaming it is compacted
Dynamic pump, above-mentioned operation principle and mode are the operation principles built in foam probe.
Control of additive raw material module is used for carry out feed supplement in fermentation tank, and controller control control of additive raw material module is come into fermentation tank
Feed supplement；Control of additive raw material module includes feed supplement tank and feed supplement peristaltic pump, and the both ends of feed supplement peristaltic pump are respectively at feed supplement tank and fermentation tank
Connection, controller require the start and stop of control feed supplement peristaltic pump to carry out feed supplement to fermentation tank according to fermentation.The control of feed supplement before fermentation
Parameter processed needs to set in the controller, and after fermentation starts, controller passes through according to the parameter of setting in the suitable period
Start feed supplement peristaltic pump and feed supplement is carried out to fermentation tank.
Air mass flow monitoring module is for the air mass flow during monitor fermentation and feeds back to controller, can control
The dissolved oxygen amount of fermentation tank；Air mass flow monitoring module includes air flow meter and air intake valve, here air flow controller
Model is D07-7M/ZM (0-6SLM)；Air intake valve is located at outside fermentation tank, air flow meter both ends be separately connected air intake valve and
Fermentation tank, air flow meter with controller by RS485 bus communications, open according to oxygen dissolving value to control air intake valve by controller
Degree is passed through the size of air mass flow to control；The size of air mass flow influences the dissolved oxygen amount in fermentation process, if the survey of dissolved oxygen
Magnitude is less than setting value, and the increase for controlling air mass flow is made the dissolved oxygen in raising zymotic fluid by air mass flow monitoring module
Amount.
Tank pressure monitoring module is for acquiring the pressure values in fermentation tank and feeding back to controller, while tank presses monitoring module energy
Enough control the pressure values in fermentation tank；It is required if pressure values meet fermentation, controller is not given instruction；If pressure values do not meet hair
Ferment requires, then controller control tank presses monitoring module to change the pressure values in fermentation tank；Tank pressure monitoring module includes that tank pressure is surveyed
The end of probe of quantity sensor and drain tap, tank pressure measurement sensor stretches into fermentation tank, and tank presses measurement sensor logical with controller
RS485 bus communications are crossed, the pressure values in fermentation tank are fed back to controller by tank pressure measurement sensor, and tank pressure measures sensing here
The model of device is PMC534-11EE2P6 (T), and controller controls the opening and closing of drain tap to control fermentation according to pressure values
Pressure values in tank.
In an advantageous embodiment：
Further include host computer, the control chip of controller uses STM32, host computer that computer can be selected man-machine to complete
Interaction, the parameters of controller are acquired display by host computer, and the parameter set will be needed to be transmitted to controller by host computer.
In temperature monitoring module, temperature control water pump controls heating-cooling with solenoid valve collective effect, and electrically heated mode is used in boiler
Water body is heated, tank temperature state of a control divides automatic control or manual control, the control mode of tank temperature automatic control be PID setting controls or
PID timing control, tank temperature can directly be heated up manually when manual or the control that cools down.Parameter setting function on computer can be passed through
Item carries out setting value (setting value of control cooling control follows variation automatically), the upper limit deviation report that setting tank temperature (heating) controls
Alert value and upper limit alarm value.When needing tank temperature electrical heating heating control, the setting value that setting tank temperature (heating) controls, by tank Wen Sheng
Warm state of a control is placed in automatic position.When tank temperature measurements be less than tank temperature setting value when, automatically turn on hot-water circulating pump into
The heating of row tank temperature controls.When needing tank temperature drop temperature control, tank temperature drop temperature state of a control is placed in automatic position.When tank temperature is surveyed
When magnitude is more than tank temperature setting value, clearance-type opens solenoid valve and circulating chilled water water pump carry out tank temperature drop temperature control system.Fermentation needs
When being heated up using thermostatted water, the setting value of thermostatted water water temperature should be set as being more than+2 DEG C~+5 DEG C or so of tank temperature setting value.It needs to make
When being heated up with thermostatted water, thermostatted water temperature state of a control is placed in automatic function state.It is set when the measured value of thermostatted water water temperature is less than
Automatically thermostatted water electrical heating heating control action is carried out when definite value.
In low whipping speed monitoring module, mixing speed outputs a control signal to frequency converter by STM32 from controller, so
Pass through Frequency Converter Control stirring motor afterwards.Setting for setting mixing speed control can be carried out by parameter setting function items on computer
Definite value, upper limit deviation alarm value and upper limit alarm value.When needing mixing speed to control, the setting of setting mixing speed control
Value, is then turned on this function.Furthermore, it is noted that stirring motor does not fill perhaps frequent start-stop, otherwise it is likely to occur due to electric current excess load
It cannot run well.
In dissolved oxygen monitoring modular, dissolved oxygen control exports control instruction to frequency converter or air inlet by STM32 from controller
Valve is controlled using adjustment mixing speed or charge flow rate.The value that dissolved oxygen setting value is set as needing, is then turned on this work(
Can, mixing speed (or charge flow rate) is adjusted automatically according to the variation of dissolved oxygen at this time.Dissolved oxygen type of alarm is that bound is absolute
Value alarms or does not alarm, and setting value, the upper limit deviation of setting dissolved oxygen control can be carried out by parameter setting function items on computer
Alarming value and the setting of lower limit deviation alarm value.
In PH monitoring modules, PH control by STM32 from controller output a control signal to acid adding, add alkali peristaltic pump into
Row acid adding adds alkali control.Setting value, the upper limit deviation alarm of PH controls can be carried out by parameter setting function items on computer
Value and the setting of lower limit deviation alarm value.PH controls can carry out automatic control or manual control, and the control mode of PH automatic controls is PID setting controls
Or PID timing control.When PH measured values are less than PH setting values, gap adds alkali；When PH measured values are higher than PH setting values, gap adds
Acid.
Control of additive raw material directly outputs a control signal to the completion of feed supplement peristaltic pump by STM32 from controller.Control of additive raw material has
Automatic control or hand control function, control mode is that switching value set time ratio controls or switching value sequential time scale when feed supplement automatic control
Control；It can direct manual ON/OFF feed supplement peristaltic pump when feed supplement manual control.
In Anti Foam Control module, defoaming action directly outputs a control signal to defoaming peristaltic pump from controller by STM32
It completes.Defoaming state of a control has automatic control or hand control function：Control mode controls for switching value set time ratio when defoaming automatic control
Or switching value sequential time scale control；Defoaming can directly manual open and close defoaming peristaltic pump when manual.When having excess foam, it is
System can also provide foam alarm signal.
In air mass flow monitoring module, the control of air mass flow by STM32 from controller output a control signal into
Air valve is completed to adjust the open degree of intake valve.The automatic control mode of air mass flow is analog quantity PID setting controls
Or analog quantity PID timing control, type of alarm are bound deviation alarm or do not alarm.Parameter setting can be by joining on computer
Number set-up function item carries out setting value, upper limit deviation alarm value and the lower limit deviation alarm value of setting flow control.It automatically controls
When：1) shut-off valve of air inlet adjustment valve is opened, and closes bypass valve；2) air mass flow can be automatically controled in setting value after a few minutes
Near.
In tank presses monitoring module, it is analog quantity PID setting controls or analog quantity PID sequential that tank, which presses the control mode of automatic control,
Control, type of alarm are bound deviation alarm or do not alarm.Parameter setting：Can by parameter setting function items on computer into
Setting value, upper limit deviation alarm value and the lower limit deviation alarm value of row setting flow control.When automatically controlling：1) exhaust is opened to adjust
The shut-off valve of valve is saved, and closes bypass valve；2) tank pressure can be automatically controled near setting value after a few minutes.
In the present invention, every fermentation can independently be adjusted by controller at any time to the real-time inspection and control of each module
Parameter so that fermentation process realizes automation.And each key modules can at any time switch under manually and automatically pattern so that
The adjustment of fermentation parameter is more flexible.
Above-described specific implementation mode has carried out further the purpose of the present invention, technical solution and advantageous effect
It is described in detail, it should be understood that the foregoing is merely the specific implementation mode of the present invention, is not intended to limit the present invention
Protection domain, all within the spirits and principles of the present invention, any modification, equivalent substitution, improvement and etc. done should all include
Within protection scope of the present invention.
Claims (10)
1. a kind of strain fermentation control system, including fermentation tank, it is characterised in that：Further include controller and multiple fermentation parameters prison
Module is controlled, the controller is for controlling multiple fermentation parameter monitoring modules to adjust the fermentation parameter in fermentation tank.
2. a kind of strain fermentation control system according to claim 1, it is characterised in that：The controller controls multiple institutes
Belong to the communication of fermentation parameter monitoring module to control the fermentation parameter in fermentation tank, the fermentation parameter monitoring module includes temperature prison
Control module, PH monitoring modules, dissolved oxygen monitoring module, mixing speed monitoring module, Anti Foam Control module, control of additive raw material module, sky
Throughput monitoring module and tank press monitoring module；
The temperature monitoring module is for acquiring the temperature data in fermentation tank and feeding back to controller, while temperature monitoring module
The temperature in fermentation tank can be controlled；It is required if temperature data meets fermentation, controller is not given instruction；If temperature data is not inconsistent
It closes fermentation to require, then controller controls temperature monitoring module to change the temperature in fermentation tank；
The PH monitoring modules are for acquiring the pH value in fermentation tank and feeding back to controller, while PH monitoring modules can control
PH value in fermentation tank；It is required if pH value meets fermentation, controller is not given instruction；If pH value does not meet fermentation and requires, control
Device processed controls PH monitoring modules to change the pH value in fermentation tank；
The dissolved oxygen monitoring module is for acquiring the oxygen dissolving value in fermentation tank and feeding back to controller, while dissolved oxygen monitoring module energy
Enough control the oxygen dissolving value in fermentation tank；It is required if oxygen dissolving value meets fermentation, controller is not given instruction；If oxygen dissolving value does not meet hair
Ferment requires, then controller controls dissolved oxygen monitoring module to change the oxygen dissolving value in fermentation tank；
The mixing speed monitoring module stirs simultaneously for acquiring the mixing speed data in fermentation tank and feeding back to controller
Speed monitoring module can control the mixing speed in fermentation tank；If the fermentation of mixing speed data fit requires, controller is not
It gives instruction；If mixing speed data do not meet fermentation and require, controller controls mixing speed monitoring module to change fermentation tank
In mixing speed；
The Anti Foam Control module is for acquiring the foam volume in fermentation tank and feeding back to controller, while Anti Foam Control module energy
Enough control the foam volume in fermentation tank；It is required if foam volume meets fermentation, controller is not given instruction；If foam volume does not meet hair
Ferment requires, then controller controls Anti Foam Control module to change the foam volume in fermentation tank；
The control of additive raw material module is used for carry out feed supplement in fermentation tank, and controller control control of additive raw material module is come into fermentation tank
Feed supplement；
The air mass flow monitoring module is for the air mass flow during monitor fermentation and feeds back to controller, can control
The dissolved oxygen amount of fermentation tank；
The tank pressure monitoring module is for acquiring the pressure values in fermentation tank and feeding back to controller, while tank presses monitoring module energy
Enough control the pressure values in fermentation tank；It is required if pressure values meet fermentation, controller is not given instruction；If pressure values do not meet hair
Ferment requires, then controller control tank presses monitoring module to change the pressure values in fermentation tank.
3. a kind of strain fermentation control system according to claim 2, it is characterised in that：The temperature monitoring module includes
Temp probe, boiler, cold water storage cistern, electrically heated rod and two temperature control water pumps, electrically heated rod are located in boiler, for heating production
Heat water；The both ends of one temperature control water pump are connect with boiler and fermentation tank respectively, the both ends of another temperature control water pump respectively with
Cold water storage cistern is connected with fermentation tank；The temp probe stretches into fermentation tank for acquiring the temperature data in fermentation tank, temperature number
It is sent to controller according to by RS485 bus communications, the controller controls opening for two temperature control water pumps according to temperature data
Stop controlling the temperature in fermentation tank.
4. a kind of strain fermentation control system according to claim 2, it is characterised in that：The PH monitoring modules include PH
Probe, alkali liquid tank, acid solution tank, acid adding peristaltic pump and add alkali peristaltic pump, wherein add alkali peristaltic pump both ends respectively with alkali liquid tank and
Fermentation tank connects, and the both ends of acid adding peristaltic pump are connect with acid solution tank and fermentation tank respectively, and the PH probes, which stretch into fermentation tank, to be used
PH value in acquisition fermentation tank, pH value be sent to controller by RS485 bus communications, and the controller is according to receiving
PH value come control acid adding, plus alkali peristaltic pump start and stop to control the pH value in fermentation tank.
5. a kind of strain fermentation control system according to claim 2, it is characterised in that：The dissolved oxygen monitoring module includes
Dissolved oxygen signal transmitting device and dissolved oxygen probe, the signal that the dissolved oxygen probe is detected is sent to dissolved oxygen signal transmitting device, molten
Oxygen signal transmitter converts the signal that dissolved oxygen probe is sent to the practical oxygen dissolving value that can be read, and dissolved oxygen signal transmitting device passes through
Oxygen dissolving value is sent to controller by RS485 bus communications, and controller is according to oxygen dissolving value come to air mass flow monitoring module and stirring
Speed monitoring module sends control instruction to control the oxygen dissolving value in fermentation tank.
6. a kind of strain fermentation control system according to claim 2, it is characterised in that：The mixing speed monitoring module
Including frequency converter and stirring motor, the output end of stirring motor is equipped with agitating paddle, and the agitating paddle of the stirring motor is located at hair
Inside fermentation tank, frequency converter is with controller by RS485 bus communications, and the frequency converter is connect with stirring motor, the controller
Control instruction is sent to control the mixing speed of stirring motor to frequency converter.
7. a kind of strain fermentation control system according to claim 2, it is characterised in that：The Anti Foam Control module includes
Foam probe, defoaming peristaltic pump and defoaming flow container, the foam probe are inserted into from the top of fermentation tank in fermentation tank, the defoaming
Peristaltic pump both ends are separately connected fermentation tank and defoaming flow container, and defoaming flow container is interior filled with antifoaming agent, and the controller is visited according to foam
The signal that head detects defoams the start and stop of peristaltic pump to control；Foam probe detects in fermentation tank controller control when having excess foam
The antifoaming agent defoamed in flow container is pumped into fermentation tank to defoam by system defoaming wriggling pump startup, defoaming peristaltic pump.
8. a kind of strain fermentation control system according to claim 2, it is characterised in that：The control of additive raw material module includes
The both ends of feed supplement tank and feed supplement peristaltic pump, feed supplement peristaltic pump are connected respectively at feed supplement tank with fermentation tank, and the controller is according to hair
Ferment requires the start and stop of control feed supplement peristaltic pump to carry out feed supplement to fermentation tank.
9. a kind of strain fermentation control system according to claim 2, it is characterised in that：The air mass flow monitoring module
Including air flow meter and air intake valve, air intake valve is located at outside fermentation tank, and the air flow meter both ends are separately connected air inlet
Valve and fermentation tank, air flow meter and controller by RS485 bus communications, the controller according to oxygen dissolving value come control into
Air valve open degree is passed through the size of air mass flow to control.
10. a kind of strain fermentation control system according to claim 2, it is characterised in that：The tank presses monitoring module packet
Tank pressure measurement sensor and drain tap are included, the end of probe of the tank pressure measurement sensor stretches into fermentation tank, and tank pressure measures sensing
For device with controller by RS485 bus communications, the pressure values in fermentation tank are fed back to controller by tank pressure measurement sensor, described
Controller controls the opening and closing of drain tap to control the pressure values in fermentation tank according to pressure values.
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| CN112457986A (en) * | 2021-01-07 | 2021-03-09 | 华润昂德生物药业有限公司 | Bioreactor for human erythropoietin injection CHO cell fermentation |
| CN112877202A (en) * | 2021-01-18 | 2021-06-01 | 刘永昶 | Automatic monitoring control system of edible and medicinal fungus liquid culture fermentation system |
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| CN112877202B (en) * | 2021-01-18 | 2024-04-16 | 天津山珍科技有限公司 | Automatic monitoring control system of edible and medicinal fungus liquid culture fermentation system |
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| CN117229901A (en) * | 2023-11-14 | 2023-12-15 | 广东省农业科学院蚕业与农产品加工研究所 | Intelligent mulberry leaf feed fermentation device |
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