CN204569936U - A kind of small-sized fermentation tank group system - Google Patents

A kind of small-sized fermentation tank group system Download PDF

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Publication number
CN204569936U
CN204569936U CN201520258376.2U CN201520258376U CN204569936U CN 204569936 U CN204569936 U CN 204569936U CN 201520258376 U CN201520258376 U CN 201520258376U CN 204569936 U CN204569936 U CN 204569936U
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China
Prior art keywords
tank
valve
seeding
chuck
control
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Expired - Fee Related
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CN201520258376.2U
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Chinese (zh)
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潘丰
廖诗来
汪谦
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Jiangnan University
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Jiangnan University
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Abstract

The utility model relates to biological fermentation equipment, is specifically related to a kind of small-sized fermentation tank group system.Comprise the seeding tank, fermentor tank and the constant temperature water tank that are connected in series by pipeline successively, pipeline is provided with cooling water intake and water outlet, steam-in and chuck sewage draining exit, clean compressed air inlet mouth and tail gas venting port; The inlet pipe of seeding tank and fermentor tank arranges strainer and air flow controller, and vapor pipe arranges strainer and ratio adjusting valve; In constant temperature water tank, set temperature sensor, liquid level sensor, electric heating tube, be connected to control device, and constant temperature water tank filling pipe arranges pneumatic on-off valve; Control device comprises the PLC of electrical connection, touch-screen, sensor, pneumatic on-off valve group and ratio adjusting valve, sensing member is arranged on seeding tank, fermentor tank and constant temperature water tank, pneumatic on-off valve group is arranged on pipeline, and control device controls fermenting process to carry out with basis.The utility model can realize biological fermentation process efficiently to carry out.

Description

A kind of small-sized fermentation tank group system
Technical field
The utility model relates to biological fermentation equipment and production process controls, and is specifically related to a kind of small-sized fermentation tank group system.
Background technology
Biological fermentation can be produced many mankind and cannot be obtained by other approach or very unobtainable synthetic.Along with the carrying out of fermentation, the concentration, cell concentration, production concentration etc. of fermented liquid mesostroma all can change, after a series of katabolism and anabolism, also can there is great variety in the volume etc. of the temperature of fermented liquid, potential of hydrogen, dissolved oxygen, fermented liquid.In fermenting process, microorganism is very responsive to its grown cultures environment, and any one factor such as temperature, dissolved oxygen, pH value, pressure, air flow quantity all may affect accretion rate, life cycle, the leavened prod Quality and yield of microbial cells.Therefore Comprehensive Control to be carried out to biological fermentation process each side factor, to ensure the speed of growth and the product qualities of thalline.
The overall automatization level of domestic existing biological fermentation process is not high, and in fermentative production, operator only realize nutrition material by rule of thumb and add or the adjustment of fermentation processes parameter.Not only troublesome poeration, and control accuracy is poor, directly affects training quality and the effect of thalline.In addition, more existing fermenting process control systems are single variable control systems, can not realize carrying out total tune control to each side factor of fermentor tank, if notification number is a kind of strain fermentation temperature controlling system disclosed in CN 203825500 U patent, control to carry out Control System Design mainly for temperature, and for example notification number is high cell density fermentation process dissolved oxygen Controlling System disclosed in CN 202201904 U patent, is only concerned about fermenting process dissolved oxygen control problem.
Current pharmaceutical industry generally comes with fermentative Production human body animal vaccine, Bian small-sized fermentation tank group (if 50L seeding tank, 500L fermentor tank are a set of production unit) is produced, in the urgent need to a kind of rational in infrastructure, small-sized fermentation tank group system that level of automation is high.
Utility model content
In order to improve the level of biological fermentation equipment, the utility model provides a kind of small-sized fermentation tank group system.
The technical scheme that the utility model adopts is: comprise the seeding tank, fermentor tank and the constant temperature water tank that are connected in series by pipeline successively, and pipeline is provided with cooling water intake and water outlet, steam-in and chuck sewage draining exit, clean compressed air inlet mouth and tail gas venting port; The tank body external mounting chuck of seeding tank and fermentor tank, suitable for reading and the end opening of seeding tank chuck and fermentor tank chuck is by pipe connecting UNICOM cooling water intake and water outlet, simultaneously the suitable for reading and end opening of chuck is by pipe connecting UNICOM steam-in and chuck sewage draining exit, and constant temperature water tank outlet at bottom and top entry distinguish the end opening of UNICOM's seed fermenter chuck and fermentor tank chuck and suitable for reading by pipe connecting; Seeding tank is connected clean compressed air inlet mouth with fermentor tank side by inlet pipe, and top is by vapor pipe UNICOM tail gas venting port; Seeding tank outlet at bottom is by pipe connecting UNICOM fermentor tank top seed entrance.
Wherein preferred version is:
Seeding tank and fermentor tank assembling top agitator motor, be connected with stirring rake by stir shaft, motor is by Frequency Converter Control rotating speed.The inlet pipe of seeding tank and fermentor tank arrange strainer and and air flow controller, air flow controller is made up of flow sensor and ratio adjusting valve; Vapor pipe arranges strainer and ratio adjusting valve.Seeding tank and fermentor tank fitting temperature sensor, PH sensor, dissolved oxygen sensor, pressure transmitter and foam sensor respectively, is connected to control device.Seeding tank and fermentor tank by connecting hose UNICOM peristaltic pump group, control device controls that peristaltic pump start and stop are carried out suitable acid adding, added alkali, feed supplement, froth breaking operation.
In constant temperature water tank, set temperature sensor, liquid level sensor, electric heating tube, be connected to control device, and constant temperature water tank filling pipe arranges pneumatic on-off valve.
Control device comprises the PLC of electrical connection, touch-screen, sensor, pneumatic on-off valve group and ratio adjusting valve, sensing member is arranged on seeding tank, fermentor tank and constant temperature water tank, pneumatic on-off valve group is arranged on pipeline, comprises pneumavalve, unidirectional stop valve and manual valve.
Advantageous Effects of the present utility model is: the whole process of control device to fermentation controls automatically, controls fermenting process and carries out with basis.The mixing speed of control device collection and monitor seeding tank and fermentor tank, air flow quantity, tank body pressure, pot temperature, PH, dissolved oxygen, foam real time data, control above variable reach target set point and meet accuracy requirement, automatic start-stop peristaltic pump, carry out acid adding, add alkali, feed supplement, froth breaking etc.By touch-screen, complete and comprise start and stop, parameter setting, data store, curve browses, the sequence of maneuvers such as report output.
Accompanying drawing explanation
Fig. 1 is the structural representation of small-sized fermentation tank group system.
Fig. 2 is the assembling schematic diagram of small-sized fermentation tank group system.
Numbering 1 in accompanying drawing 2, 11 is PH sensors, 2, 12, 18 is temperature sensors, 3, 13 is dissolved oxygen sensors, 4, 14 is pressure transmitters, 5, 15 is mass flow controllers, 6, 16 is froth breaking electrodes, 7, 17 is chucks, 8 is seeding tanks, 9 is constant temperature water tanks, 10 is fermentor tanks, 19 is electric heating tubes, 20 is fermentor tank product exit, 21 is entrance of cooling water, 22 is cooling water outlets, 23 is venting ports, 24 is chuck sewage draining exits, 25 is steam-ins, 26 is uncontaminated air entrances after filtering, 27, 28 is peristaltic pump groups, 29, 30 is water pumps, 31, 32 is agitator motors, 33 is automatic exhaust steam valves, 34 is liquid level sensors, 35 is seeding tank discharge filters, 36 is fermentor tank discharge filters, V1 is ratio adjusting valve group, V2 is sanitation-grade diaphragm valve group, V3 is check valve group, V4 is pneumavalve group, V5 is sanitary grade ball valve group.
Embodiment
Below in conjunction with accompanying drawing 2, embodiment of the present utility model is described further:
Embodiment 1:
As shown in Figure 1, seeding tank 8, constant temperature water tank 9 and fermentor tank 10 is connected by multiple-way duct.Seeding tank 8, constant temperature water tank 9 and fermentor tank 10 adopt stainless steel plate to be welded, and machinery and electrochemical etching are taked, smooth surface in surface simultaneously, are unfavorable for growing and enrichment of bacterium.Seeding tank chuck 7 and fermentor tank chuck 17 suitable for reading respectively by ball valve V5-1 and V5-11 UNICOM steam-in 25, the end opening of seeding tank chuck 7 is by ball valve V5-5 and drain valve V5-4 UNICOM chuck sewage draining exit 24, the end opening of fermentor tank chuck 17 passes through ball valve V5-14 and drain valve V5-15 UNICOM chuck sewage draining exit 24, the steam sterilizing before starting for fermenting.
Seeding tank outlet at bottom is by hand valve V2-5 and V2-6 and pipe connecting UNICOM fermentor tank top seed entrance.
Seeding tank chuck 7 end opening is connected with cooling water inlet 21 with bypass ball valve V5-3 by pneumavalve V4-2, is connected with check valve V3-3 by pneumavalve V4-4 with water pump 29 and constant temperature water tank 9 water outlet.Seeding tank chuck 7 is suitable for reading to be connected with cooling water outlet 22 with bypass ball valve V5-2 by pneumavalve V4-1, is connected with pneumavalve V4-3 by check valve V3-2 with constant temperature water tank 9 water return outlet.Tank body is connected with uncontaminated air entrance 26 by hand valve V2-4, check valve V3-1, uncontaminated air control valve group (V2-1, V2-2, V2-3, wherein V2-1 is by-pass valve, V2-2 with V2-3 is stopping valve) and mass flow controller 5.Seeding tank 8 top is connected with venting port 23 by hand valve V2-7, discharge filter 35, ratio adjusting valve V1-1 and by-pass valve V5-6.Agitator motor 31 is equipped with at seeding tank 8 top, pressure transmitter 4, foam electrode 6, peristaltic pump group 27, PH sensor 1, temperature sensor 2, dissolved oxygen sensor 3 are installed on tank wall and go deep in fermented liquid.
Fermentor tank chuck 17 end opening is connected with cooling water inlet 21 with bypass ball valve V5-13 by pneumavalve V4-12, is connected with check valve V3-13 by pneumavalve V4-14 with water pump 30 and constant temperature water tank 9 water outlet.Fermentor tank chuck 17 is suitable for reading to be connected with cooling water outlet 22 with bypass ball valve V5-12 by pneumavalve V4-11, is connected with pneumavalve V4-13 by check valve V3-12 with constant temperature water tank 9 water return outlet.Tank body is connected with uncontaminated air entrance 26 by hand valve V2-14, check valve V3-11, uncontaminated air control valve group (V2-11, V2-12, V2-13, wherein V2-11 is by-pass valve, V2-12 with V2-13 is stopping valve) and mass flow controller 15.Fermentor tank 10 top is connected with venting port 23 by hand valve V2-17, discharge filter 36, ratio adjusting valve V1-2 and by-pass valve V5-16.Agitator motor 32 is equipped with at fermentor tank 10 top, pressure transmitter 14, foam electrode 16, peristaltic pump group 28, PH sensor 11, temperature sensor 12, dissolved oxygen sensor 13 are installed on tank wall and go deep in fermented liquid.
Seeding tank 8 and fermentor tank 10 respectively by pipe connecting UNICOM peristaltic pump group 27,28, control device controls that peristaltic pump start and stop are carried out suitable acid adding, added alkali, feed supplement, froth breaking operation.
Constant temperature water tank 9 is mainly used in as seeding tank and fermentor tank insulation provide constant-temperature hot water.Constant temperature water tank 9 top fitting temperature sensor 18, gathers water tank temperature signal to control device.Electric heating tube 19 is equipped with in bottom, and control device controls its constant temperature water tank and heats, and bottom is by ball valve V5-6 UNICOM chuck sewage draining exit.Left and right outlet connects water-circulating pump 29,30 respectively, and conveying thermostat(t)ed water is to seeding tank chuck and fermentor tank chuck.Constant temperature water tank 9 top assembling liquid level sensor 34, when liquid level is low, control device starts automatic water compensating valve V4-15 and carries out moisturizing.The automatic exhaust steam valve 33 at constant temperature water tank 9 top is for getting rid of gas in case.
Control device adopts PLC control technology, completes the hand of whole fermenting process, automatically controls.Control device comprises the unit such as PLC, touch-screen, sensor, regulating and controlling valve, frequency transformer and forms.What touch-screen was selected is Delta DOP-B series product, and menu in Chinese formula designs, and makes operative employee be easy to grasp.PLC adopts Delta ES2 series product, and all by-pass valve controls all select German precious Supreme Being's valve.PLC is delivered to control device by each sensor collecting temperature, pressure, flow, PH, dissolved oxygen, foam signal, and control device, through process, outputs control signals to each control valve, completes control task.
Original pipeline, regulating and controlling valve group, saturated steam generator device, water coolant and pneumatic plant in the utility model, and electric heating system, Controlling System are common prior art, it arranges and uses as industry technician is grasped.
Principle of work: (seeding tank is consistent with fermentor tank control mode, hereby only for seeding tank control mode, describes whole control process.)
When constant temperature water tank 9 temperature currency is lower than set(ting)value, electric heating tube 19 electrified regulation, carries out intensification and controls.When currency is higher than set(ting)value, electric heating tube 19 power-off.Experience provides: constant temperature water tank temperature generally controls exceeding 2-3 DEG C than tank body design temperature.
When tank body 8 temperature currency is lower than set(ting)value, water pump 29 and pneumavalve V4-3, V4-4 open, and in constant temperature water tank, thermostat(t)ed water enters chuck 7, carry out intensification and control.When currency is higher than set(ting)value, pneumavalve V4-1, V4-2 open automatically, enter water coolant, carry out cooling and control.
When air flow quantity currency is lower than set(ting)value, air inlet adjustment valve V2-4 ratio aperture increases, and uncontaminated air increases, and flow increases.When currency is lower than set(ting)value, air inlet adjustment valve V2-4 ratio aperture reduces, and uncontaminated air reduces, and flow reduces.
When tank body pressure currency is lower than set(ting)value, ratio adjusting valve V1-1 ratio aperture reduces, tank body pressure increase.When currency is higher than set(ting)value, air inlet adjustment valve V1-1 ratio aperture increases, and tank body pressure reduces.
PH currency is lower than when adding alkali set(ting)value, and the alkali peristaltic pump interval that adds of peristaltic pump group 27 is opened, in fermented liquid, add alkaline material.Currency is higher than acid adding set(ting)value, and the acid adding peristaltic pump interval of peristaltic pump group 27 is opened, in fermented liquid, add acid material.In tank, foam is too much, touches foam electrode, and foam is reported to the police, and the froth breaking peristaltic pump of peristaltic pump group 27, by the start and stop of certain hour scale batch, adds defoamer in fermented liquid.Setting-up time interval start and stop feed supplement pump can be needed to carry out feed operation according to use.
It is more than preferred embodiment of the present utility model, not any pro forma restriction is done to the utility model, every according to technical spirit of the present utility model to any amendment made for any of the above embodiments, equivalent variations and modification, all belong in the scope of utility model technical scheme.

Claims (7)

1. a small-sized fermentation tank group system, comprises the seeding tank, fermentor tank and the constant temperature water tank that are connected in series by pipeline successively, and pipeline is provided with cooling water intake and water outlet, steam-in and chuck sewage draining exit, clean compressed air inlet mouth and tail gas venting port; The tank body external mounting chuck of seeding tank and fermentor tank, suitable for reading and the end opening of seeding tank chuck and fermentor tank chuck is by pipe connecting UNICOM cooling water intake and water outlet, simultaneously the suitable for reading and end opening of chuck is by pipe connecting UNICOM steam-in and chuck sewage draining exit, and constant temperature water tank outlet at bottom and top entry distinguish the end opening of UNICOM's seed fermenter chuck and fermentor tank chuck and suitable for reading by pipe connecting; Seeding tank is connected clean compressed air inlet mouth with fermentor tank side by inlet pipe, and top is by vapor pipe UNICOM tail gas venting port; Seeding tank outlet at bottom is by pipe connecting UNICOM fermentor tank top seed entrance.
2. a kind of small-sized fermentation tank group system according to claim 1, is characterized in that, seeding tank and fermentor tank assembling top agitator motor, be connected with stirring rake by stir shaft, motor passes through Frequency Converter Control rotating speed.
3. a kind of small-sized fermentation tank group system according to claim 1, it is characterized in that, control device comprises the PLC of electrical connection, touch-screen, sensor, pneumatic on-off valve group and ratio adjusting valve, sensing member is arranged on seeding tank, fermentor tank and constant temperature water tank, pneumatic on-off valve group is arranged on pipeline, comprises pneumavalve, unidirectional stop valve and manual valve; Control device controls fermenting process to carry out with basis.
4. a kind of small-sized fermentation tank group system according to claim 1, it is characterized in that, the inlet pipe of seeding tank and fermentor tank arranges air flow controller, and air flow controller is made up of flow sensor and ratio adjusting valve; Vapor pipe arranges strainer and ratio adjusting valve.
5. a kind of small-sized fermentation tank group system according to claim 1, is characterized in that, seeding tank and fermentor tank fitting temperature sensor, PH sensor, dissolved oxygen sensor, pressure transmitter and foam sensor respectively, is connected to control device.
6. a kind of small-sized fermentation tank group system according to claim 1, is characterized in that, seeding tank and fermentor tank by connecting hose UNICOM peristaltic pump group, control device controls that peristaltic pump start and stop are carried out suitable acid adding, added alkali, feed supplement, froth breaking operation.
7. a kind of small-sized fermentation tank group system according to claim 1, it is characterized in that, in constant temperature water tank, set temperature sensor, liquid level sensor, electric heating tube, be connected to control device, and constant temperature water tank filling pipe arranges pneumatic on-off valve.
CN201520258376.2U 2015-04-24 2015-04-24 A kind of small-sized fermentation tank group system Expired - Fee Related CN204569936U (en)

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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105087375A (en) * 2015-09-10 2015-11-25 即墨市第一职业中等专业学校 Strain continuous fermentation device
CN105238640A (en) * 2015-10-31 2016-01-13 庞巧兰 Fruit wine fermentation tank
CN106381267A (en) * 2016-08-31 2017-02-08 西安若翰生物饲料有限公司 Simple efficient solid fermentation device
CN106399084A (en) * 2016-09-14 2017-02-15 冯艳忠 Probiotic culture system
CN107475106A (en) * 2017-09-19 2017-12-15 北京艾吾丁医药科技有限公司 A kind of fully-automatic intelligent fermentation system
CN107557291A (en) * 2017-09-22 2018-01-09 南京律智诚专利技术开发有限公司 A kind of intelligent controlling device of Zymolysis Equipment
CN107646525A (en) * 2017-10-31 2018-02-02 翔天农业开发集团股份有限公司 A kind of liquid spawn fermentation tank pH stable method and its device

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105087375A (en) * 2015-09-10 2015-11-25 即墨市第一职业中等专业学校 Strain continuous fermentation device
CN105238640A (en) * 2015-10-31 2016-01-13 庞巧兰 Fruit wine fermentation tank
CN106381267A (en) * 2016-08-31 2017-02-08 西安若翰生物饲料有限公司 Simple efficient solid fermentation device
CN106399084A (en) * 2016-09-14 2017-02-15 冯艳忠 Probiotic culture system
CN106399084B (en) * 2016-09-14 2019-05-28 冯艳忠 Probiotic's culture system
CN107475106A (en) * 2017-09-19 2017-12-15 北京艾吾丁医药科技有限公司 A kind of fully-automatic intelligent fermentation system
CN107557291A (en) * 2017-09-22 2018-01-09 南京律智诚专利技术开发有限公司 A kind of intelligent controlling device of Zymolysis Equipment
CN107646525A (en) * 2017-10-31 2018-02-02 翔天农业开发集团股份有限公司 A kind of liquid spawn fermentation tank pH stable method and its device

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Granted publication date: 20150819

Termination date: 20160424