CN108310258A - A kind of Medicated Leaven composition and preparation method thereof - Google Patents
A kind of Medicated Leaven composition and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to a kind of preparation methods of Medicated Leaven, and the Medicated Leaven being prepared using this method.Preparation method of the present invention is using specific raw material proportioning and specific fermentation step and condition, alpha amylase, malto-oligosaccharide enzyme and proteinase activity are above existing Medicated Leaven in the Medicated Leaven being prepared, with better quality, and the large-scale production of prepared slices of Chinese crude drugs factory can be applied to.
Description
Technical field
The present invention relates to a kind of preparation methods of Medicated Leaven, and the Medicated Leaven being prepared using this method.
Background technology
Medicated Leaven also known as Divine Comedy, be one kind by flour, wheat bran, rde bean, semen armeniacae amarae, sweet wormwood, Siberian cocklebur grass, polygonum flaccidum by certain
Conventional Chinese medicine medicine materical crude slice made of ratio fermentation.Medicated Leaven primary efficacy is strengthening the spleen and stomach, in the tune that helps digestion, main retention of food and drink；Digestion
It is bad；Abdominal fullness and distention；Loss of appetite；Vomiting dysentery etc..Medicated Leaven is in the prescribed preparation that national standard is recorded using most
Fermentation class Chinese medicine.
Medicated Leaven is although widely used, but uncharged in going through edition Chinese Pharmacopoeia, only in ministry standard and each place
It is recorded in concocted specification, but prescription disunity, concocting method are rough.The existing method for preparing Medicated Leaven uses a variety of differences
Raw material proportioning, Medicated Leaven product quality obtained is irregular, inventor by further investigation find, using the present invention it is specific
Raw material proportioning can obtain optimal synergistic function, by raw material carry out particular procedure, and to zymotechnique carry out
It improves, more conducively wherein the fermentation of dominant bacteria and conversion, alpha-amylase, malto-oligosaccharide enzyme and egg in Medicated Leaven obtained
White enzymatic activity is above commercially available Medicated Leaven, has better quality, and can apply to the large-scale production of prepared slices of Chinese crude drugs factory.
Invention content
It is an object of the invention to provide a kind of preparation methods of improved Medicated Leaven to have better quality and drug effect to obtain
Medicated Leaven composition.
The purpose of the present invention is what is be achieved through the following technical solutions.
The present invention provides a kind of preparation method of Medicated Leaven, it is characterised in that includes the following steps：By following parts by weight
Than weighing following raw material medicaments：3 parts of rde bean, 3 parts of semen armeniacae amarae, 16 parts of sweet wormwood, 16 parts of polygonum flaccidum, 16 parts of Siberian cocklebur grass, 120 parts of flour,
120 parts of wheat bran；Decocting liquid is filtered to obtain by being added water to cook after sweet wormwood, polygonum flaccidum, the chopping of Siberian cocklebur seedling；Rde bean, semen armeniacae amarae are crushed, with wheat
Bran and flour mixing are added the decocting liquid mixing fermentation, product are obtained after dry.Wherein sweet wormwood, polygonum flaccidum and Siberian cocklebur grass are dry product.This
Involved sweet wormwood, polygonum flaccidum and Siberian cocklebur grass, are dry product unless otherwise specified in text.
Preparation in accordance with the present invention, it is preferable that the preparation method further includes the steps that rde bean first ferments, system
Obtain Semen Phaseoli fermented product；It by Semen Phaseoli fermented product, the semen armeniacae amarae of crushing, is mixed with wheat bran and flour, the decocting liquid mixing is added
Fermentation obtains product after dry.
Preparation in accordance with the present invention, it is preferable that the preparation method further includes the steps that crushing wheat bran：By wheat bran
It is ground into 10 mesh powder below；It by Semen Phaseoli fermented product, the semen armeniacae amarae of crushing, is mixed with wheat bran powder and flour, institute is added
The fermentation of decocting liquid mixing is stated, product is obtained after dry.
Preparation in accordance with the present invention, it is preferable that when wheat bran being ground into 10 mesh or less and being more than 40 mesh powder,
It by Semen Phaseoli fermented product, the semen armeniacae amarae of crushing, mixes, is added after softwood is made in the decocting liquid mixing with wheat bran powder and flour,
First be compacted it is blocking ferment, be then cut into small pieces excipient again, it is dry after product.
Preparation in accordance with the present invention, it is preferable that when wheat bran is ground into 40 mesh powder below, sent out by rde bean
Ferment object, crushing semen armeniacae amarae, mixed with wheat bran powder and flour, be added after softwood is made in the decocting liquid mixing, be first cut into fritter
Then excipient ferments again, product is obtained after dry.
Preparation in accordance with the present invention, it is preferable that the actual conditions of the drying steps are to be dried at a temperature of 35 DEG C
It gets product, finished product can be dried 72 hours to obtain at a temperature of 35 DEG C.
Preparation in accordance with the present invention, it is preferable that described the step of preparing sweet wormwood, polygonum flaccidum, Siberian cocklebur seedling decocting liquid, specifically
For：It will be added water to cook after sweet wormwood, polygonum flaccidum, the chopping of Siberian cocklebur seedling, and be filtered after boiling and concentrate filtrate to flour and wheat bran total amount
75% obtains decocting liquid.
Preparation in accordance with the present invention, it is preferable that the fermentation condition of all mixed fermentation steps of raw material is：Fermentation
30~35 DEG C of temperature, humidity 70~80% of fermenting, fermentation time 2~3 days.
Preparation in accordance with the present invention, it is preferable that the rde bean fermentation step includes being processed into rde bean slightly
Powder adds water to cook 2 hours into atherosclerotic, and it is spare that fermentation obtains fermentate in 2 days.
The present invention also provides according to Medicated Leaven composition made from any one above-mentioned preparation method.
In the Medicated Leaven that preparation method of the present invention obtains alpha-amylase, malto-oligosaccharide enzyme and proteinase activity be above with
Medicated Leaven made from existing preparation method has better quality and therapeutic effect, and it is big to apply to prepared slices of Chinese crude drugs factory
Large-scale production.
Description of the drawings
Fig. 1 is product excipient situation when decocting liquid to be concentrated into the 75% of flour plus wheat bran amount of embodiment 1 in table 6.
Fig. 2 is product excipient situation when decocting liquid to be concentrated into the 50% of flour plus wheat bran amount in table 6.
Fig. 3 is product excipient situation when decocting liquid to be concentrated into the 85% of flour plus wheat bran amount in table 6.
Specific implementation mode
With reference to specific embodiment, the present invention is further illustrated, but protection scope of the present invention is not limited to
This.This part carries out general description to the material and test method that are arrived used in present invention experiment.Although to realize
Many materials and operating method used in the object of the invention are it is known in the art that still the present invention still makees as far as possible herein
Detailed description.It will be apparent to those skilled in the art that hereinafter, if not specified, material therefor of the present invention and operating method
It is well known in the art.During the present invention discusses, including in embodiment and comparative example, each taste raw material proportioning for preparing Medicated Leaven is
Quality proportioning.
Inventor is by using spectrophotometry to alpha-amylase in Medicated Leaven sample, malto-oligosaccharide enzyme and protease
Vigor is measured, with alpha-amylase, malto-oligosaccharide enzyme and mmp reaction Medicated Leaven quality, as inspection Medicated Leaven quality
Index.
Inventor is by further investigation, by largely testing discoverys, carbon source (wheat bran and flour) and nitrogen source (rde bean and
Almond) ratio, the ratio of carbon source and medicine (sweet wormwood, polygonum flaccidum and Siberian cocklebur grass), wheat bran and flour the different degrees of shadow of ratio regular meeting
Ring the quality of Medicated Leaven, binding Modern microbiological fermentating law, using six god made from specific raw material proportioning of the invention
Song has better quality and drug effect.Inventor, which also found, first crushes raw material wheat bran, is crushed and 10 mesh or less are made
Powder, then carry out mixed fermentation with other raw materials, be especially 10 mesh or less, 40 mesh or more crushing wheat bran
Powder when, after raw material is mixed and made into softwood, first ferment excipient again, and by wheat bran crush be 40 mesh powder below when,
After raw material is mixed and made into softwood, first excipient ferments again, and the Medicated Leaven product being prepared is with more enzymatic activity high and preferably
Quality.Meanwhile inventor is also found in the course of the research by controlling reaction condition, especially controls the drying of product after fermentation
For temperature at 35 DEG C, the Medicated Leaven product being prepared has more enzymatic activity high；And control sweet wormwood, polygonum flaccidum, Siberian cocklebur seedling decocting liquid
It is concentrated into the 75% of the flour plus wheat bran amount excipient for being more conducive to product.
The present invention provides a kind of preparation method of Medicated Leaven, includes the following steps：
Following raw material medicaments are weighed by following weight part ratio：3 parts of rde bean, 3 parts of semen armeniacae amarae, 16 parts of sweet wormwood, 16 parts of polygonum flaccidum,
16 parts of Siberian cocklebur grass, 120 parts of flour, 120 parts of wheat bran, the sweet wormwood, polygonum flaccidum and Siberian cocklebur grass are dry product；
Sweet wormwood, polygonum flaccidum, Siberian cocklebur seedling decocting liquid are prepared, can will specifically add water to cook, boil after sweet wormwood, polygonum flaccidum, the chopping of Siberian cocklebur seedling
It filters afterwards and concentrates filtrate to flour and the 75% of wheat bran total amount and obtain decocting liquid；
Semen armeniacae amarae is crushed spare, it is spare semen armeniacae amarae can be ground into coarse powder；
Rde bean is crushed it is spare, or rde bean first carried out ferment Semen Phaseoli fermented product is spare, specifically can will be red
Red bean is processed into coarse powder, adds water to cook 2 hours into atherosclerotic, it is spare that fermentation obtains fermentate in 2 days；
It is spare that wheat bran is ground into 10 mesh powder below；
It is mixed by the semen armeniacae amarae of crushing, with the rde bean or Semen Phaseoli fermented product that crush and the wheat bran and flour that crush
Close, be added the decocting liquid be uniformly mixed, be made hold it is agglomerating, throw i.e. dissipate softwood；
When wheat bran to be ground into 10 mesh or less and more than 40 mesh powder, it is preferable that raw material is being mixed and made into softwood
Afterwards, be first compacted it is blocking ferment, be then cut into small pieces excipient again, it is dry after product.
When wheat bran is ground into 40 mesh powder below, it is preferable that after raw material is mixed and made into softwood, be first cut into small
Block excipient, then ferments again, and product is obtained after dry.
Wherein, the actual conditions of the drying steps can be to dry 72 hours and get product at a temperature of 35 DEG C.
Wherein, can be by the fermentation condition of the mixed fermentation step of all raw materials：30~35 DEG C of fermentation temperature, fermentation are wet
Degree 70~80%, fermentation time 2~3 days.It can also ferment in fermenting case, preferably be sent out in fermenting case with spontaneous fermentation
Ferment.
Embodiment 1
Weigh raw material：Flour 3000g, wheat bran 3000g, sweet wormwood 400g, polygonum flaccidum 400g, Siberian cocklebur grass 400g, rde bean 75g,
Semen armeniacae amarae 75g；Rde bean is processed into coarse powder, adds water to cook 2 hours into atherosclerotic, fermentation 2 days is spare；By sweet wormwood, polygonum flaccidum, Siberian cocklebur
Seedling shreds, and the water that 8 times of amounts are added decocts, and is filtered after boiling 15 minutes, and what filtrate was concentrated into flour plus wheat bran amount 75% must decoct
Liquid is spare；Wheat bran is crushed, 10 mesh sieve is crossed；Coarse powder is made in semen armeniacae amarae crushing, with Semen Phaseoli fermented product, wheat bran powder, flour
Mixing, the decocting liquid is added, stir evenly be made hold it is agglomerating, throw i.e. dissipate softwood；Softwood obtained is packed into mould, pressure
It is real blocking, it takes out；It sets in fermenting case, keeps 30 DEG C of temperature, humidity 70%, ferment 2 days, when white mould clothing is born on surface, take out,
It is cut into the cubic block of 6mm, is dried 72 hours at 35 DEG C, obtains Medicated Leaven product A.
Embodiment 2
Weigh raw material：Flour 3000g, wheat bran 3000g, sweet wormwood 400g, polygonum flaccidum 400g, Siberian cocklebur grass 400g, rde bean 75g,
Semen armeniacae amarae 75g；Rde bean is processed into coarse powder, adds water to cook 2 hours into atherosclerotic, fermentation 2 days is spare；By sweet wormwood, polygonum flaccidum, Siberian cocklebur
Seedling shreds, and the water that 8 times of amounts are added decocts, and is filtered after boiling 15 minutes, and what filtrate was concentrated into flour plus wheat bran amount 75% must decoct
Liquid is spare；Wheat bran is crushed, 40 mesh sieve is crossed；Coarse powder is made in semen armeniacae amarae crushing, with Semen Phaseoli fermented product, wheat bran powder, flour
Mixing, the decocting liquid is added, stir evenly be made hold it is agglomerating, throw i.e. dissipate softwood；Softwood obtained is cut into the vertical of 9mm
Square is subsequently placed in fermenting case, keeps 35 DEG C of temperature, humidity 80%, is fermented 3 days, when white mould clothing is born on surface, is taken out,
It is dried 72 hours at 35 DEG C, obtains Medicated Leaven product B.
Embodiment 3
To first be fermented in embodiment 2 after obtained softwood the excipient that is cut into small pieces again, then be dried, other operations and implementation
Example 2 is identical, obtains Medicated Leaven products C.
Comparative example 1
According to《Drug Standard of Ministry of Public Health of the Peoples Republic of China (the 19th)》It is prepared by the concocting method of middle record.It weighs
Raw material：Flour 2500g, wheat bran 5000g, semen armeniacae amarae 100g, rde bean 100g, polygonum flaccidum 500g, sweet wormwood 500g, Siberian cocklebur grass 500g,
Semen armeniacae amarae, red bean powder are broken into coarse powder, with flour, wheat bran mixing, polygonum flaccidum, sweet wormwood, Siberian cocklebur grass are separately taken to add water to cook 1 hour, filter
It crosses, filtrate is condensed into clear cream, is mixed thoroughly while hot with above-mentioned medicinal powder, keeps proper temperature and humidity, spontaneous fermentation to surface is all over raw yellow
White or the mould clothing of canescence take out, and crush, dry, obtain Medicated Leaven product.The product is the prepared slices of Chinese crude drugs, commercially available.From Guangxi and
Sichuan acquires the product 1,2 being prepared using this method respectively.
Comparative example 2
According to《Beijing's prepared slices of Chinese crude drugs concocted specification》It is prepared by the concocting method recorded in (2008 editions).Weigh raw material：Face
Powder 100kg, semen armeniacae amarae 4kg, rde bean 4kg, fresh polygonum flaccidum 7kg (dry product 2.3kg), fresh sweet wormwood 7kg (dry product 2.3kg), fresh Siberian cocklebur
Seedling 7kg (dry product 2.3kg)；It takes rde bean to be processed into coarse powder, adds water to cook 2 hours into atherosclerotic, ferment 2 days, it is spare；Separately take bitter apricot
Benevolence, sweet wormwood, polygonum flaccidum, Siberian cocklebur seedling are respectively crushed into coarse powder, and flour and rde bean congee mixing, and agglomerating, the dissipating of throwing held is made
Softwood.It sets in appropriate vessel, upper cover piemarker leaf, keeps 30 DEG C of temperature, humidity 70%, ferment 2 days, wait for that white mould clothing is born on surface
When, it takes out, removes piemarker leaf；Round or 6mm cubic blocks are cut into rubbing, are dried at 70 times, are obtained Medicated Leaven product.The product is
The prepared slices of Chinese crude drugs, it is commercially available.Acquire the product 3,4 being prepared using this method respectively from Beijing.
3~comparative example of comparative example 5
Medicated Leaven product is prepared according to the method for embodiment 1, in the case where other operations are constant, is matched using different material
Than preparing Medicated Leaven.Specific material rate is shown in Table 2.
Inventor uses spectrophotometry, measures in the Medicated Leaven and commercially available Medicated Leaven sample that the method for the present invention is prepared
The enzyme activity of alpha-amylase, malto-oligosaccharide enzyme and protease, the results show that the Medicated Leaven being prepared using the method for the present invention
Alpha-amylase, malto-oligosaccharide enzyme and protease the enzyme activity of enzyme activity especially malto-oligosaccharide enzyme be apparently higher than other
Medicated Leaven product (is shown in Table 1).The method of spectrophotometry used by measurement enzyme activity is for the art conventional method and often
Rule technology, in the prior art existing perfect explanation can refer to pertinent literature (such as " different sources Medicated Leaven malto-oligosaccharide enzyme activity
Power Comparative experiments ", contemporary Chinese Chinese medicine, the 7th phase of volume 18 in 2016).
1 Medicated Leaven product of the present invention of table and commercially available Medicated Leaven product enzymatic activity data
Inventor is found through experiments that, for the prescription of Medicated Leaven, carbon source (flour+wheat bran) and nitrogen source (rde bean+
Semen armeniacae amarae) ratio, the ratio of wheat bran and flour and carbon source and medicine (sweet wormwood, polygonum flaccidum, Siberian cocklebur grass) ratio be influence fermentation
As a result with the principal element of enzymatic activity.The ratio of carbon source and nitrogen source is controlled 40:1, flour and the control of wheat bran ratio are 1:1,
Carbon source and the control of medicine ratio are 5:1, Medicated Leaven obtained has better enzymatic activity (being shown in Table 2).
The different prescription ratios of table 2 influence Medicated Leaven product enzymatic activity
Inventor has found that it is that 10 mesh powder below is subsequently used for preparing to smash raw material wheat bran, and Medicated Leaven obtained has
Better enzymatic activity.Inventor during studying influence of the Medicated Leaven preparation method to Product Activity, it has been unexpectedly discovered that,
By raw material wheat bran smash be 40 mesh powder below when, the enzymatic activity of the sequence of follow-up excipient and fermentation to final Medicated Leaven product
It has an impact and (is shown in Table 3).According to the inventor's study, according to the preparation method of the present invention for preparing Medicated Leaven, when by wheat bran
When crushing powder below for 40 mesh, using fritter, the sequence that excipient ferments again is first cut, product obtained has better enzyme activity
Property.
Influence of the 3 wheat bran grinding particle size of table with excipient and fermentation step sequence to Medicated Leaven product enzymatic activity
Inventor is during studying influence of the Medicated Leaven preparation method to Product Activity, by largely studying and trying
Work discovery is tested, controls the drying temperature of final Medicated Leaven product at 35 DEG C, obtained Medicated Leaven has optimal enzyme activity
Property.Prepare Medicated Leaven product according to the method for embodiment 1, other operation it is constant in the case of, control final products not
It is dried under synthermal, Medicated Leaven product obtained has different enzymatic activitys (being shown in Table 4).
Influence of 4 drying temperature of table to Medicated Leaven product enzymatic activity
Rde bean is processed into coarse powder by inventor's discovery, is added water to cook 2 hours into atherosclerotic, is used to prepare after first fermenting 2 days,
Medicated Leaven obtained has better enzymatic activity.Medicated Leaven product is prepared according to the method for embodiment 1, is operated at other constant
In the case of, it by rde bean therein without first fermentation process, is changed to crush rde bean, then carry out the preparation of other steps,
Medicated Leaven obtained has different enzymatic activitys (being shown in Table 5).
5 rde bean co-fermentation of table and rde bean first ferment comparative experiments result
Inventor is during studying influence of the Medicated Leaven preparation method to Product Activity, by largely studying and trying
Work discovery is tested, sweet wormwood, polygonum flaccidum, Siberian cocklebur seedling decocting liquid enrichment factor have an impact Medicated Leaven molding.When by sweet wormwood, polygonum flaccidum, Siberian cocklebur seedling
When decocting liquid is concentrated into the 75% of flour plus wheat bran amount, obtained Medicated Leaven raw material can be preferably molded, and be square fritter.
Medicated Leaven product is prepared according to the method for embodiment 1, in the case where other operations are constant, change sweet wormwood, polygonum flaccidum, Siberian cocklebur seedling and decocts
Liquid concentration ratio, be concentrated into the 50% and 85% of flour plus wheat bran amount respectively, to Medicated Leaven excipient generate Different Effects (see
Table 6).
The influence of 6 sweet wormwood of table, polygonum flaccidum, Siberian cocklebur seedling decocting liquid enrichment factor to Medicated Leaven excipient
Present invention is not limited to the embodiments described above, without departing from the essence of the present invention, this field skill
Any deformation, improvement, the replacement that art personnel are contemplated that are within the scope of the present invention.
Claims (10)
1. a kind of preparation method of Medicated Leaven, which is characterized in that include the following steps：Following originals are weighed by following weight part ratio
Expect medicine：3 parts of rde bean, 3 parts of semen armeniacae amarae, 16 parts of sweet wormwood, 16 parts of polygonum flaccidum, 16 parts of Siberian cocklebur grass, 120 parts of flour, 120 parts of wheat bran；It will
It is added water to cook after sweet wormwood, polygonum flaccidum, the chopping of Siberian cocklebur seedling and filters to obtain decocting liquid；Rde bean, semen armeniacae amarae are crushed, it is mixed with wheat bran and flour
It closes, the decocting liquid mixing fermentation is added, product is obtained after dry.
2. preparation method according to claim 1, which is characterized in that the preparation method further includes the step that rde bean first ferments
Suddenly, Semen Phaseoli fermented product is made；It by Semen Phaseoli fermented product, the semen armeniacae amarae of crushing, is mixed with wheat bran and flour, the decocting liquid is added
Mixing is fermented, and product is obtained after dry.
3. preparation method according to claim 2, which is characterized in that the preparation method further includes the steps that crushing wheat bran：
Wheat bran is ground into 10 mesh powder below；By Semen Phaseoli fermented product, the semen armeniacae amarae of crushing, mixed with wheat bran powder and flour,
The decocting liquid mixing fermentation is added, product is obtained after dry.
4. preparation method according to claim 3, which is characterized in that wheat bran is ground into 10 mesh or less and is more than 40 mesh powders
When, by the semen armeniacae amarae of Semen Phaseoli fermented product, crushing, mixed with wheat bran powder and flour, be added the decocting liquid mixing be made it is soft
After material, be first compacted it is blocking ferment, be then cut into small pieces excipient again, it is dry after product.
5. preparation method according to claim 3, which is characterized in that when wheat bran is ground into 40 mesh powder below, will be red
Red bean fermentate, crushing semen armeniacae amarae, mixed with wheat bran powder and flour, be added after softwood is made in the decocting liquid mixing, first cut
It at fritter excipient, then ferments again, product is obtained after dry.
6. preparation method according to claim 4 or 5, which is characterized in that the actual conditions of the drying steps are, in 35 DEG C of temperature
The lower drying finished product of degree.
7. preparation method according to claim 6, which is characterized in that described the step of preparing sweet wormwood, polygonum flaccidum, Siberian cocklebur seedling decocting liquid,
Specially：It will be added water to cook after sweet wormwood, polygonum flaccidum, the chopping of Siberian cocklebur seedling, filtered after boiling and concentrate filtrate to flour and wheat bran total amount
75% decocting liquid.
8. preparation method according to claim 7, which is characterized in that the fermentation condition of all mixed fermentation steps of raw material
For, 30~35 DEG C of fermentation temperature, humidity 70~80% of fermenting, fermentation time 2~3 days.
9. preparation method according to claim 8, which is characterized in that the rde bean fermentation step includes processing rde bean
At coarse powder, 2 hours are added water to cook into atherosclerotic, it is spare that fermentation obtains fermentate in 2 days.
10. according to Medicated Leaven composition made from claim 1~9 any one of them preparation method.
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| CN110201099A (en) * | 2019-06-14 | 2019-09-06 | 四川辅正药业股份有限公司 | The method of Pediococcus pentosaceus pure-blood ferment Medicated Leaven |
| CN112022971A (en) * | 2020-08-07 | 2020-12-04 | 中国中药有限公司 | Medicated leaven composition and preparation method thereof |
| CN112603969A (en) * | 2020-12-18 | 2021-04-06 | 河北林益堂药业有限公司 | Large-scale controllable fermentation method of Massa Medicata Fermentata with ten thousand-level cleanliness |
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