CN108310073A - A kind of prepared slices of Chinese crude drugs and preparation method thereof - Google Patents
A kind of prepared slices of Chinese crude drugs and preparation method thereof Download PDFInfo
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- CN108310073A CN108310073A CN201810321326.2A CN201810321326A CN108310073A CN 108310073 A CN108310073 A CN 108310073A CN 201810321326 A CN201810321326 A CN 201810321326A CN 108310073 A CN108310073 A CN 108310073A
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- radix paeoniae
- paeoniae alba
- chinese crude
- crude drugs
- yellow rice
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/17—Preparation or pretreatment of starting material involving drying, e.g. sun-drying or wilting
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
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- Pharmacology & Pharmacy (AREA)
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- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
It is the radix paeoniae alba ultra-fine powder of the mesh of granularity >=500 the invention discloses a kind of prepared slices of Chinese crude drugs.The invention also discloses the preparation methods of the prepared slices of Chinese crude drugs.The present invention crushes the Radix Paeoniae Alba after enzymolysis and wine bran, and the radix paeoniae alba ultra-fine powder for obtaining the mesh of granularity >=500 dissolves in vivo, infiltration rate is fast, improves uptake.Meanwhile Radix Paeoniae Alba, through digesting with after wine bran, the content of principle active component increases in radix paeoniae alba decoction pieces, if albiflorin content is higher than 2.1%, paeonol content 16.2%, paeoniflorin content 4.0%.
Description
Technical field
The present invention relates to a kind of prepared slices of Chinese crude drugs, and in particular to a kind of Radix Paeoniae Alba prepared slices of Chinese crude drugs and preparation method thereof.
Background technology
Radix Paeoniae Alba is is conventional Chinese medicine, and main product is in provinces such as Zhejiang, Anhui, Sichuan.Radix Paeoniae Alba is cool in nature, and bitter acid is slightly cold, has and mend
Blood blood-nourishing, suppressing liver-YANG, the analgesic of soft liver, astringing YIN to stop sweating and other effects are suitable for fever due to yin deficiency, irregular menstruation, four limbs contraction urgency, rush down dysentery
The diseases such as abdominal pain, spontaneous sweating, uterine bleeding.Modern medicine study shows：Paeoniflorin has antibacterial, antipyretic, anti-inflammatory, increase coronary artery stream
It measures, improves myocardial nutritional flow, expansion blood vessel, confrontation acute myocardial ischemia, inhibit platelet aggregation, calmness, analgesia, resist and burst
Ulcer, the effect for adjusting blood glucose.
There are many concocting method, traditional concocting methods parched with wine, vinegar-fried, native stir-fry for Radix Paeoniae Alba.It is processed through traditional concocting method
Afterwards, paeoniflorin content significantly reduces, and poor taste, bitter, is unfavorable for clinical drug use.In recent years, rarely have to Radix Paeoniae Alba big gun
The improved report of method processed.
Radix Paeoniae Alba traditional diamond-making technique is to be dried after removing the peel boiling, however, due to lacking specific technical parameter and index, is made
No specification, which must be processed, to be followed.Radix paeoniae alba decoction pieces traditional diamond-making technique is to be sliced, and active ingredient dissolves out in the radix paeoniae alba decoction pieces of slice processing
Speed is slow, dissolution is not thorough, disadvantages such as low of extract yield, can only generally steep in wine, Baoshang, fricassee, in immersion or high temperature for a long time
In decoction process, the nutritional ingredient in Radix Paeoniae Alba can be destroyed.
Invention content
The object of the present invention is to provide it is a kind of can retain Radix Paeoniae Alba main active, the system of Ultramicro-powder to ensure its effect
Preparation Method.
The technical solution adopted in the present invention is as follows：
A kind of prepared slices of Chinese crude drugs, the prepared slices of Chinese crude drugs are the radix paeoniae alba ultra-fine powder of the mesh of granularity >=500.
A kind of preparation method of the prepared slices of Chinese crude drugs of the present invention, includes the following steps：
1) it cleans
Fresh Radix Paeoniae Alba is chosen, after carrying out water cleaning, peeling, the bulk of 3-5mm is cut into, in the ironed 2-4min of boiling water；
2) it digests
Cellulase is added in blocky Radix Paeoniae Alba after step 1) cleaning treatment and pectase digests, hydrolysis temperature 30-35
DEG C, enzymolysis time is 2-3 hours；
3) dry
Radix Paeoniae Alba raw material after step 2) is digested is dried to water content at a temperature of being placed in 55-60 DEG C be 3-5%；
4) wine bran
After 15% yellow rice wine of Radix Paeoniae Alba raw material addition after taking step 3) dry is gradually moisturized to Radix Paeoniae Alba slice completely, it is dry to take out nature
It is dry；Radix Paeoniae Alba slice is mixed with 15% wheat bran and is placed in baking oven, in 150-200 DEG C of baking time be 10-15min；It takes out,
Filtering removes wheat bran, puts naturally spare after cool；
5) it crushes
It takes the Radix Paeoniae Alba after step 4) wine bran to be first ground into the coarse powder of 160-200 mesh, then carries out ultramicro grinding in a manner of ball milling,
A small amount of powder is taken to measure granularity, when powder size >=500 mesh, vacuum packaging.
Based on the above technical solution, step 2) enzymolysis process is：By the blocky Radix Paeoniae Alba after step 1) cleaning treatment
1g is pressed with deionized water:Deionized water is added in the ratio of 100mL, be then added deionized water weight 0.1% cellulase and
0.4% pectase.
Further, it is soaked described in step 4) wine bran and is：
By the weight of Radix Paeoniae Alba, 2.0-4.0 times of 15% yellow rice wine is weighed, yellow rice wine is equably sprayed on to Radix Paeoniae Alba slice under agitation, until
Until moistened surface；After moistened surface 5 hours, stirring down and spray appropriate yellow rice wine again, addition yellow rice wine to Radix Paeoniae Alba slice moisturizes completely, and
Container bottom is remained without yellow rice wine.
Compared with prior art, advantage of the invention is that：
The present invention crushes the Radix Paeoniae Alba after enzymolysis and wine bran, the radix paeoniae alba ultra-fine powder for obtaining the mesh of granularity >=500 dissolves in vivo,
Infiltration rate is fast, improves uptake.Meanwhile Radix Paeoniae Alba, through digesting with after wine bran, the content of principle active component increases in Radix Paeoniae Alba
Add, if albiflorin content is higher than 2.1%, paeonol content 16.2%, paeoniflorin content 4.0%, water-soluble leaching
Object content is higher than 25.0% higher than 35.2%, ethanol soluble extractives content.
Preparation method science of the present invention is controllable, and not only technique is compared with simple, extraction cost is relatively low, but also reduces main effective
The loss of ingredient.
Specific implementation mode
The technical scheme in the embodiments of the invention will be clearly and completely described below, it is clear that described implementation
Example is only a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, this field is common
The every other embodiment that technical staff is obtained without making creative work belongs to the model that the present invention protects
It encloses.
Embodiment 1
A kind of preparation method of the prepared slices of Chinese crude drugs, includes the following steps：
1) it cleans
Fresh Radix Paeoniae Alba is chosen, after carrying out water cleaning, peeling, is cut into bulk；
2) it digests
Blocky Radix Paeoniae Alba after step 1) cleaning treatment is pressed into 1g with deionized water:Deionized water is added in the ratio of 100mL, then adds
Enter the cellulase of deionized water weight 0.1% and 0.4% pectase；
3) dry
It is 4% that Radix Paeoniae Alba raw material after step 2) is digested, which is placed at a temperature of 60 DEG C and is dried to water content,；
4) wine bran
By the weight of Radix Paeoniae Alba, 3 times of 15% yellow rice wine is weighed, yellow rice wine is equably sprayed on to Radix Paeoniae Alba slice under agitation, until surface is moistened
Until wet；It after moistened surface 5 hours, stirs down and sprays appropriate yellow rice wine again, addition yellow rice wine to Radix Paeoniae Alba slice moisturizes completely, and container bottom
Portion is remained without yellow rice wine；It takes out and spontaneously dries；Radix Paeoniae Alba slice is mixed with 15% wheat bran and is placed in baking oven, when toasting for 180 DEG C
Between be 12min；It takes out, filtering removes wheat bran, puts naturally spare after cool；
5) it crushes
It takes the Radix Paeoniae Alba after step 4) wine bran to be first ground into the coarse powder of 160-200 mesh, then carries out ultramicro grinding in a manner of ball milling,
A small amount of powder is taken to measure granularity, when powder size >=500 mesh, vacuum packaging.
It is prepared by the measurement reference substance solution of active ingredient Paeoniflorin and paeonol content：
Precision weighs Paeoniflorin and Paeonol reference substance is appropriate, adds methanol that every 2mL is made and contains 531.44 μ g of Paeoniflorin, the root bark of tree peony respectively
The mixed reference substance solution of 4.76 μ g of phenol, shakes up, 4 DEG C of storages, spare.
It is prepared by test solution：
Precision weighs the radix paeoniae alba ultra-fine powder 0.1g of the present embodiment, sets in 5mL measuring bottles, adds 70% appropriate amount of ethanol, ultrasonic extraction
20min takes out and stands, is cooled to room temperature, is settled to scale with 70% ethyl alcohol, shakes up, through 0.22 μm of filtering with microporous membrane, take
Subsequent filtrate to get.
Chromatographic condition：
Instrument is Agilent 1020；Chromatographic column is：C18；Mobile phase is acetonitrile：0.1% disodium hydrogen phosphate aqueous solution (50：
50), gradient elution；Detection wavelength is 230nm；Flow velocity is 0.6mL/min；Column temperature is 30 DEG C.
Testing result shows the Paeoniflorin of the present embodiment（Average out to 4.0%）, Paeonol（Average out to 16.2%）Content
Obviously higher than traditional concocting method（Compared with the present embodiment, the difference is that without last pulverising step, Paeoniflorin
Average content is 3.0%, Paeonol average content is 15.1%）, it is white to illustrate that the processing procedure of the present invention can effectively ensure
The content of active ingredient in Chinese herbaceous peony medicine materical crude slice.
Embodiment 2
A kind of preparation method of the prepared slices of Chinese crude drugs, includes the following steps：
1) it cleans
Fresh Radix Paeoniae Alba is chosen, after carrying out water cleaning, peeling, is cut into bulk；
2) it digests
Blocky Radix Paeoniae Alba after step 1) cleaning treatment is pressed into 1g with deionized water:Deionized water is added in the ratio of 100mL, then adds
Enter the cellulase of deionized water weight 0.1% and 0.4% pectase；
3) dry
It is 3% that Radix Paeoniae Alba raw material after step 2) is digested, which is placed at a temperature of 55 DEG C and is dried to water content,；
4) wine bran
By the weight of Radix Paeoniae Alba, 3 times of 15% yellow rice wine is weighed, yellow rice wine is equably sprayed on to Radix Paeoniae Alba slice under agitation, until surface is moistened
Until wet；It after moistened surface 5 hours, stirs down and sprays appropriate yellow rice wine again, addition yellow rice wine to Radix Paeoniae Alba slice moisturizes completely, and container bottom
Portion is remained without yellow rice wine；It takes out and spontaneously dries；Radix Paeoniae Alba slice is mixed with 15% wheat bran and is placed in baking oven, when toasting for 200 DEG C
Between be 10min；It takes out, filtering removes wheat bran, puts naturally spare after cool；
5) it crushes
It takes the Radix Paeoniae Alba after step 4) wine bran to be first ground into the coarse powder of 160-200 mesh, then carries out ultramicro grinding in a manner of ball milling,
A small amount of powder is taken to measure granularity, when powder size >=500 mesh, vacuum packaging.
Embodiment 3
A kind of preparation method of the prepared slices of Chinese crude drugs, includes the following steps：
1) it cleans
Fresh Radix Paeoniae Alba is chosen, after carrying out water cleaning, peeling, is cut into bulk；
2) it digests
Blocky Radix Paeoniae Alba after step 1) cleaning treatment is pressed into 1g with deionized water:Deionized water is added in the ratio of 100mL, then adds
Enter the cellulase of deionized water weight 0.1% and 0.4% pectase；
3) dry
It is 5% that Radix Paeoniae Alba raw material after step 2) is digested, which is placed at a temperature of 60 DEG C and is dried to water content,；
4) wine bran
By the weight of Radix Paeoniae Alba, 4 times of 15% yellow rice wine is weighed, yellow rice wine is equably sprayed on to Radix Paeoniae Alba slice under agitation, until surface is moistened
Until wet；It after moistened surface 5 hours, stirs down and sprays appropriate yellow rice wine again, addition yellow rice wine to Radix Paeoniae Alba slice moisturizes completely, and container bottom
Portion is remained without yellow rice wine；It takes out and spontaneously dries；Radix Paeoniae Alba slice is mixed with 15% wheat bran and is placed in baking oven, when toasting for 150 DEG C
Between be 15min；It takes out, filtering removes wheat bran, puts naturally spare after cool；
5) it crushes
It takes the Radix Paeoniae Alba after step 4) wine bran to be first ground into the coarse powder of 160-200 mesh, then carries out ultramicro grinding in a manner of ball milling,
A small amount of powder is taken to measure granularity, when powder size >=500 mesh, vacuum packaging.
Claims (4)
1. a kind of prepared slices of Chinese crude drugs, it is characterised in that：The prepared slices of Chinese crude drugs are the radix paeoniae alba ultra-fine powder of the mesh of granularity >=500.
2. a kind of preparation method of prepared slices of Chinese crude drugs as described in claim 1, which is characterized in that include the following steps：
1) it cleans
Fresh Radix Paeoniae Alba is chosen, after carrying out water cleaning, peeling, is cut into bulk；
2) it digests
Cellulase is added in blocky Radix Paeoniae Alba after step 1) cleaning treatment and pectase digests, hydrolysis temperature 30-35
DEG C, enzymolysis time is 2-3 hours；
3) dry
Radix Paeoniae Alba raw material after step 2) is digested is dried to water content at a temperature of being placed in 55-60 DEG C be 3-5%；
4) wine bran
After 15% yellow rice wine of Radix Paeoniae Alba raw material addition after taking step 3) dry is gradually moisturized to Radix Paeoniae Alba slice completely, it is dry to take out nature
It is dry；Radix Paeoniae Alba slice is mixed with 15% wheat bran and is placed in baking oven, in 150-200 DEG C of baking time be 10-15min；It takes out,
Filtering removes wheat bran, puts naturally spare after cool；
5) it crushes
It takes the Radix Paeoniae Alba after step 4) wine bran to be first ground into the coarse powder of 160-200 mesh, then carries out ultramicro grinding in a manner of ball milling,
A small amount of powder is taken to measure granularity, when powder size >=500 mesh, vacuum packaging.
3. a kind of preparation method of the prepared slices of Chinese crude drugs as described in claim 1, which is characterized in that enzymolysis described in step 2)
Cheng Wei：Blocky Radix Paeoniae Alba after step 1) cleaning treatment is pressed into 1g with deionized water:Deionized water is added in the ratio of 100mL, then
The cellulase of deionized water weight 0.1% and 0.4% pectase is added.
4. a kind of preparation method of the prepared slices of Chinese crude drugs as described in claim 1, which is characterized in that moisten described in step 4) wine bran
It is wet to be：By the weight of Radix Paeoniae Alba, 2.0-4.0 times of 15% yellow rice wine is weighed, yellow rice wine is equably sprayed on to Radix Paeoniae Alba slice under agitation, until
Until moistened surface；After moistened surface 5 hours, stirring down and spray appropriate yellow rice wine again, addition yellow rice wine to Radix Paeoniae Alba slice moisturizes completely, and
Container bottom is remained without yellow rice wine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201810321326.2A CN108310073A (en) | 2018-04-11 | 2018-04-11 | A kind of prepared slices of Chinese crude drugs and preparation method thereof |
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| CN201810321326.2A CN108310073A (en) | 2018-04-11 | 2018-04-11 | A kind of prepared slices of Chinese crude drugs and preparation method thereof |
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| CN108310073A true CN108310073A (en) | 2018-07-24 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115381897A (en) * | 2021-05-25 | 2022-11-25 | 四川新荷花中药饮片股份有限公司 | Preparation method of fritillaria cirrhosa powder |
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| CN102908412A (en) * | 2012-09-28 | 2013-02-06 | 浙江百草中药饮片有限公司 | Radix paeoniae alba ultra-fine powder and preparation method thereof |
| CN103300412A (en) * | 2013-06-27 | 2013-09-18 | 叶建斌 | Health-care baked egg for nourishing blood and removing blood stasis and preparation method thereof |
| CN103315021A (en) * | 2013-06-27 | 2013-09-25 | 叶建斌 | Vitality nourishing bread and preparation method thereof |
| CN103392764A (en) * | 2013-06-27 | 2013-11-20 | 叶建斌 | Milk cake for nourishing vital energy and preparation method of milk cake |
| CN104771460A (en) * | 2015-04-20 | 2015-07-15 | 安徽精诚本草中药饮片有限公司 | Fabrication method of radix paeoniae alba decoction pieces |
| CN105232656A (en) * | 2015-10-13 | 2016-01-13 | 王茜 | Processing method of white peony root decoction pieces containing wine and wheat bran |
-
2018
- 2018-04-11 CN CN201810321326.2A patent/CN108310073A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102908412A (en) * | 2012-09-28 | 2013-02-06 | 浙江百草中药饮片有限公司 | Radix paeoniae alba ultra-fine powder and preparation method thereof |
| CN103300412A (en) * | 2013-06-27 | 2013-09-18 | 叶建斌 | Health-care baked egg for nourishing blood and removing blood stasis and preparation method thereof |
| CN103315021A (en) * | 2013-06-27 | 2013-09-25 | 叶建斌 | Vitality nourishing bread and preparation method thereof |
| CN103392764A (en) * | 2013-06-27 | 2013-11-20 | 叶建斌 | Milk cake for nourishing vital energy and preparation method of milk cake |
| CN104771460A (en) * | 2015-04-20 | 2015-07-15 | 安徽精诚本草中药饮片有限公司 | Fabrication method of radix paeoniae alba decoction pieces |
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| Title |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115381897A (en) * | 2021-05-25 | 2022-11-25 | 四川新荷花中药饮片股份有限公司 | Preparation method of fritillaria cirrhosa powder |
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Application publication date: 20180724 |