CN105232656A - Processing method of white peony root decoction pieces containing wine and wheat bran - Google Patents
Processing method of white peony root decoction pieces containing wine and wheat bran Download PDFInfo
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- CN105232656A CN105232656A CN201510670108.6A CN201510670108A CN105232656A CN 105232656 A CN105232656 A CN 105232656A CN 201510670108 A CN201510670108 A CN 201510670108A CN 105232656 A CN105232656 A CN 105232656A
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- radix paeoniae
- paeoniae alba
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Abstract
The invention discloses a processing method of white peony root decoction pieces containing wine and wheat bran and relates to the field of processing of traditional Chinese medicinal materials. The processing method combines traditional processing methods including wine moistening and stir-baking with bran and is improved based on the traditional processing methods. Compared with the traditional processing methods, the processing method has the advantages that content of active ingredients in the white peony root decoction pieces prepared by the processing method is increased; processing time is shortened greatly, and production efficiency is improved; the white peony root decoction pieces processed by the processing method are improved in taste, has slightly bitter taste and is beneficial to clinical application.
Description
Technical field
The present invention relates to the processing technique field of Chinese crude drug, be specifically related to the concocting method of a kind of wine bran Radix Paeoniae Alba.
Background technology
The Radix Paeoniae Alba is the dry root of ranunculaceae plant Radix Paeoniae (Paeonialactiflora), one of " eight Zhe's ", the ministerial drug in classics recipe Baizhu Shaoyao San is conventional Chinese medicine, main product in Zhejiang, Anhui, Sichuan, Guizhou, the province such as Shandong, be all artificial culture.Containing compositions such as peoniflorin, paeonol, peonin, lactone glucoside of Radix Paeoniae, oxypaeoniflorins in the Radix Paeoniae Alba, Radix Paeoniae Alba total glucosides comprises the monoterpene glycosides compositions such as peoniflorin, Hydroxy peoniflorin, benzoylpaeoniflorin and lactone glucoside of Radix Paeoniae.The Radix Paeoniae Alba is cool in nature, and bitter in the mouth acid, is slightly cold, has the effects such as blood-supplementing blood-nourishing, suppressing liver-YANG, easing the affected liver to relieve pain, astringing YIN to stop sweating, is applicable to fever due to yin deficiency, menoxenia, the breast abdomen pain over the hypochondriac region, extremity contraction suddenly, dysentery stomachache, spontaneous sweating, metrorrhagia, the inferior disease of band.Paeoniflorin has antibacterial, antipyretic, antiinflammatory, increase coronary flow, improves the effect of myocardial nutritional flow, blood vessel dilating, antagonism acute myocardial ischemia, anticoagulant, calmness, analgesia, spasmolytic, antiulcer, adjustment blood glucose.Modern medicine study shows: paeoniflorin has antibacterial, antipyretic, antiinflammatory, increase coronary flow, improves the effect of myocardial nutritional flow, blood vessel dilating, antagonism acute myocardial ischemia, anticoagulant, calmness, analgesia, spasmolytic, antiulcer, adjustment blood glucose.The Radix Paeoniae Alba has multiple concocting method, and traditional concocting method has wine stir-fry, vinegar is fried, parching with earth.After traditional concocting method is concocted, paeoniflorin content all significantly reduces, and mouthfeel is poor, bitter in the mouth, is unfavorable for that clinical drug uses.In recent years, the report that Radix Paeoniae Alba concocting method is improved is rarely had.
Summary of the invention
The object of the invention is to avoid the deficiencies in the prior art, the concocting method of a kind of wine bran Radix Paeoniae Alba is provided.
In order to realize object of the present invention, concrete technical scheme is as follows:
1, clean the dry root of ranunculaceae plant Radix Paeoniae (Paeonialactiflora), section, is placed in moistening cylinder;
2, by the weight of the Radix Paeoniae Alba, take 1.0 ~ 1.5 times of 15% yellow wine, be placed in aerosol apparatus, stir, while yellow wine is sprayed on equably Radix Paeoniae Alba section, to moistened surface;
3, after moistening 1.5-3.0 hour, stir, then spray appropriate yellow wine, moistening, and stir every now and then, add yellow wine and run through completely to Radix Paeoniae Alba section, and container bottom remains without yellow wine; Take out, natural drying;
4, Radix Paeoniae Alba section fully mixed with 15% Testa Tritici, be placed in baking oven, high temperature (150-200 DEG C) baking time is 10-15min; Take out, filter, removing Testa Tritici, naturally cools, obtains Radix Paeoniae Alba decoction pieces.
Further, the described Radix Paeoniae Alba and the mass ratio of Testa Tritici are 1:1.5 ~ 2.5;
Compared with prior art, advantage of the present invention is: concocting method of the present invention combines traditional concocting method wine and fries and parched with bran, and concocting method is improved, compared with traditional concocting method, in the Radix Paeoniae Alba decoction pieces that concocting method of the present invention obtains, the content of effective ingredient all increases, the processing in production place research of the Radix Paeoniae Alba mainly concentrate on softening, whether remove the peel, cooking technology, cutting process, stove drying and take advantage of fresh processing technique etc., generally need 2 ~ 4 days, time-consuming.Concocting method of the present invention reduces process time greatly, improves production efficiency.And improve through the Radix Paeoniae Alba decoction pieces mouthfeel that the present invention concocts, mildly bitter flavor, is conducive to Clinical practice.Through the Radix Paeoniae Alba decoction pieces that the present invention concocts, lactone glucoside of Radix Paeoniae content is higher than 1.5%, and paeoniflorin content 3.7%, water-soluble extractives content is higher than 35%, and ethanol-soluble extractives content is higher than 25.12%.
Accompanying drawing explanation
Fig. 1 is Radix Paeoniae Alba reference substance (A) and Radix Paeoniae Alba test sample (B) HPLC chromatogram
Detailed description of the invention
Embodiment 1
1, clean the dry root of 2.0kg ranunculaceae plant Radix Paeoniae (Paeonialactiflora), section, is placed in moistening cylinder;
2, take 3.0kg15% yellow wine, be placed in aerosol apparatus, stir, while yellow wine is sprayed on equably Radix Paeoniae Alba section, to moistened surface;
3, moistening is after 1.5 hours, stirs, then sprays appropriate yellow wine, moistening, and stirs every now and then, add yellow wine and run through completely to Radix Paeoniae Alba section, and container bottom remains without yellow wine; Take out, natural drying;
4, Radix Paeoniae Alba section is fully mixed with 3.0kg15% Testa Tritici, be placed in baking oven, 150 DEG C of high-temperature baking 10min; Take out, filter, removing Testa Tritici, naturally cools, obtains Radix Paeoniae Alba decoction pieces.
Embodiment 2
The determination test of wine bran Radix Paeoniae Alba decoction pieces effective ingredient
1, water-soluble extractives measures
With reference to " water-soluble extractives algoscopy (hot dipping) " under " Chinese Pharmacopoeia " version (one) " Extract mensuration " (annex XA) item in 2010.Sample thief powder, puts 60 DEG C of dry 1h in baking oven, cools, get 2g, accurately weighed, put in 250mL conical flask, precision adds distilled water 100mL, jam-pack, weighed weight, leave standstill 1h, condensing reflux, keeps micro-1h that boils, let cool rear taking-up conical flask, weigh, mend heavy, shake up, dry filter filters, and precision measures 25mL and puts in the dry evaporating dish of constant weight, water bath method, 105 DEG C of dry 3h, put exsiccator cooling, fast precision weighing.Measure its leaching rate, leaching rate (%)=(M ware+leaching.
Table 1 alcoholic solution determination of extractives result
2, the mensuration of peoniflorin, lactone glucoside of Radix Paeoniae, benzoylpaeoniflorin, paeonol content
2.1 reference substance solution preparations
It is appropriate that precision takes lactone glucoside of Radix Paeoniae, peoniflorin, benzoylpaeoniflorin and paeonol reference substance, add methanol and make every 1mL respectively containing lactone glucoside of Radix Paeoniae 117.86 μ g, peoniflorin 265.72 μ g, benzoylpaeoniflorin 7.84 μ g, the mixing reference substance solution of paeonol 2.38 μ g, shake up, 4 DEG C of storages, for subsequent use.
2.2 need testing solution preparations
Precision takes Radix Paeoniae Alba decoction pieces powder (crossing No. 4 sieves) 0.1g, puts in 5mL measuring bottle, adds 70% appropriate amount of ethanol, supersound extraction 20min (supersonic frequency: 40KHz; Ultrasonic electric power: 150W), take out and leave standstill, be cooled to room temperature, be settled to scale with 70% ethanol, shake up, through 0.22 μm of filtering with microporous membrane, get subsequent filtrate, to obtain final product.
2.3 chromatographic condition
Adopt ACQUITYUPLCHSST3 chromatographic column (2.1mm × 100mm, 1.8 μm); Mobile phase is acetonitrile (A)-0.05% phosphate aqueous solution (B), gradient elution; Determined wavelength is 230nm; Flow velocity is 0.4mLmin-1; Column temperature is 30 DEG C; Sample size be 2 μ L under above-mentioned chromatographic condition, Radix Paeoniae Alba need testing solution is detecting chromatographic peak to the corresponding retention time place of lactone glucoside of Radix Paeoniae, peoniflorin, benzoylpaeoniflorin and paeonol reference substance chromatographic peak.(shown in note figure, 1,2,3,4 are respectively lactone glucoside of Radix Paeoniae as shown in Figure 1 for reference substance and test sample chromatogram; Peoniflorin; Benzoylpaeoniflorin; Paeonol) content of peoniflorin, lactone glucoside of Radix Paeoniae, benzoylpaeoniflorin, paeonol in sample, the results are shown in Table 2.
The assay of effective ingredient in table 2 sample
Experimental result shows, peoniflorin is easily destroyed in the Radix Paeoniae course of processing, peoniflorin, benzoylpaeoniflorin, paeonol average content, all apparently higher than traditional concocting method, illustrate that processing procedure of the present invention effectively can ensure the content of effective ingredient in Radix Paeoniae Alba decoction pieces.
With reference to 2010 editions " Chinese Pharmacopoeia " high effective liquid chromatography for measuring, measurement result: be not less than 3.3% containing peoniflorin in every gram of processed product.
The Radix Paeoniae Alba decoction pieces of tradition Preparation process and the Radix Paeoniae Alba decoction pieces of this Preparation process carry out comparative study by under " Chinese Pharmacopoeia " 2010 editions detections.Result of the test shows, after adopting concocting method of the present invention to concoct, reduce the loss of effective component of paeonia lactiflora, make the content of effective ingredient without significant change and change obviously compared with the increase mouthfeel of the more traditional processed white peony root of finished product concocted out of the finished product content that traditional method is concocted, bitterness removes substantially, reduces the property of the bitter cold of crude drug.And can make its cell wall breaking, thus macromole changes micromolecule into, is more conducive to absorbing.
Claims (2)
1. a concocting method for wine bran Radix Paeoniae Alba decoction pieces, is characterized in that: comprise the following steps:
(1), clean the dry root of ranunculaceae plant Radix Paeoniae (Paeonialactiflora), section, is placed in moistening cylinder;
(2), by the weight of the Radix Paeoniae Alba, take 1.0 ~ 1.5 times of 15% yellow wine, be placed in aerosol apparatus, stir, yellow wine is sprayed on equably the Radix Paeoniae Alba on one side and cuts into slices, to moistened surface;
(3), after moistening 1.5-3.0 hour, stir, then spray appropriate yellow wine, moistening, and stir every now and then, add yellow wine and run through completely to Radix Paeoniae Alba section, and container bottom remains without yellow wine; Take out, natural drying;
(4), by Radix Paeoniae Alba section fully mix with 15% Testa Tritici, be placed in baking oven, high temperature (150-200 DEG C) baking time is 10-15min; Take out, filter, removing Testa Tritici, naturally cools, obtains Radix Paeoniae Alba decoction pieces.
2. the concocting method of a kind of wine bran Radix Paeoniae Alba decoction pieces according to claim 1, is characterized in that: in step (4), the mass ratio of the Radix Paeoniae Alba and Testa Tritici is 1:1.5 ~ 2.5.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108310073A (en) * | 2018-04-11 | 2018-07-24 | 亳州市天济药业有限公司 | A kind of prepared slices of Chinese crude drugs and preparation method thereof |
| CN110522799A (en) * | 2019-10-15 | 2019-12-03 | 安徽协和成药业饮片有限公司 | A kind of concocting method of radix paeoniae alba decoction pieces |
-
2015
- 2015-10-13 CN CN201510670108.6A patent/CN105232656A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108310073A (en) * | 2018-04-11 | 2018-07-24 | 亳州市天济药业有限公司 | A kind of prepared slices of Chinese crude drugs and preparation method thereof |
| CN110522799A (en) * | 2019-10-15 | 2019-12-03 | 安徽协和成药业饮片有限公司 | A kind of concocting method of radix paeoniae alba decoction pieces |
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