CN108309383A - One kind being used for endovascular medical treatment device - Google Patents

One kind being used for endovascular medical treatment device Download PDF

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Publication number
CN108309383A
CN108309383A CN201810064436.5A CN201810064436A CN108309383A CN 108309383 A CN108309383 A CN 108309383A CN 201810064436 A CN201810064436 A CN 201810064436A CN 108309383 A CN108309383 A CN 108309383A
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China
Prior art keywords
interlude
segment
section
inner tube
capsule
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CN201810064436.5A
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Chinese (zh)
Inventor
王国辉
王震
吴建平
薛宗玉
张坤
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Shanghai Wei Wei Medical Technology Co Ltd
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Shanghai Wei Wei Medical Technology Co Ltd
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Priority to CN201810064436.5A priority Critical patent/CN108309383A/en
Publication of CN108309383A publication Critical patent/CN108309383A/en
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12099Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
    • A61B17/12109Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/12136Balloons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61M1/0023
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/84Drainage tubes; Aspiration tips
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/10Balloon catheters
    • A61M25/1011Multiple balloon catheters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22051Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for with an inflatable part, e.g. balloon, for positioning, blocking, or immobilisation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22079Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for with suction of debris
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/10Balloon catheters
    • A61M25/1011Multiple balloon catheters
    • A61M2025/1013Multiple balloon catheters with concentrically mounted balloons, e.g. being independently inflatable

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Reproductive Health (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Biophysics (AREA)
  • Pulmonology (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

The present invention provides one kind being used for endovascular medical treatment device, including slender member and expandable capsule, the slender member includes the proximal segment for being connect with handle, the distal ports for carrying the capsule and the interlude between the proximal segment and distal ports, the interlude includes at least first segment, second segment and third section, proximally to being distally arranged in order, the hardness of the first segment, second segment and third section is different from for the first segment, second segment, third section.The part of device provided by the invention in the blood vessels has better compliance compared to existing apparatus.

Description

One kind being used for endovascular medical treatment device
Technical field
The present invention relates to one kind being used for endovascular medical treatment device, more particularly to one kind can be realized effectively in a low voltage state The device that blood vessel blocks, can be used for temporary plugging vascular flow, absorbs vascular thrombosis by negative pressure or auxiliary all kinds of takes bolt instrument It completes blood vessel machinery and takes bolt, or as other interposing catheters or the accessory channel etc. of instrument, belong to the field of medical instrument technology.
Background technology
The intravascular intervention diagnosing and treating therapeutic modality minimally invasive as one, recently as iconography equipment into The introducing improvement of step, novel intervention equipment is quickly developed, and blood vessel intervention doctor, which can be handled, to become increasingly complex The case of lesion, clinical application is more and more, and the disease being related to is also more and more extensive.However, one of facing difficulty at present To solve the problems, such as to be, conduit is operated in the blood vessels or generates clast bolt when conveying the sacculus, holder or plugging device of interventional treatment Subflow causes distal vessels to occlude to blood vessel distal end.
The interventional technique of the cranial vascular disease minimally-invasive treatment mode representative as one, recently as iconography The progress of equipment, the introducing of novel intervention equipment are quickly developed, and cranial nerve intervention doctor can have been handled increasingly Complicated lesion, the case of clinical application is more and more, and the disease being related to is also more and more extensive.
The machinery of bolt instrument is taken to take bolt or led using sacculus by balloon guide catheter conveying intervention in the cerebrovascular The therapy that pipe completes to inhale bolt has many advantages, such as that bleeding is few, wound is small, few intercurrent disease, safe and reliable, post-operative recovery is fast, becomes The bright spot of acute ischemic cerebral apoplexy treatment, there is revascularization rate more higher than vein or Arterial thrombolysis and broader treatment time Window.
《Acute ischemic cerebral apoplexy China Consensus of experts 2017 editions》Middle report, take bolt access select key be whether Use balloon guide catheter and centre/suction catheter;NASA registration researchs are included in 138 of 24 centers and are led using sacculus altogether The patient of guiding tube, compared with unused balloon guide catheter person, user's recanalization rate is higher, distal embolization rate and dystopy Thrombosis rate indifference, clinical prognosis desirable rate is high within 3 months;Multinomial logistic regression shows using balloon guide catheter to be to face The independent influencing factor of bed prognosis bona.The Solumbra technologies assisted using intermediate conductor can significantly improve MCA block cabinets Tool takes the success rate of bolt, reduces distal embolization rate and dystopy thrombosis rate.Experiment in vitro further confirms, during holder takes bolt to combine Between/suction catheter suction can reduce hard and crisp thromboembolism distal vessels event, joint balloon guide catheter can significantly drop The distal embolization event of low fresh red thrombus, therefore balloon guide catheter and centre/suction catheter possibility are used in combination in embolectomy With clinical meaning.
Balloon guide catheter occupation mode is:By the interventional procedure of standard, percutaneous puncture is placed in arterial sheath, and auxiliary takes bolt device Tool reaches vascular thrombosis proximal end, so that it is attached at vascular wall by balloon inflation, temporary interruption blood flow forms partial sealing; Under external negative pressure cooperation, bolt instrument and thrombus will be taken to adsorb the inner cavity into conduit.Then the sacculus for shrinking balloon guide catheter, is returned Balloon guide catheter is removed, takes thrombus out of human body to achieve the purpose that blood flow is rebuild.
Balloon guide catheter auxiliary intervention apparatus completes the mechanical critical issue for taking bolt or individually inhaling bolt:1, sacculus compared with Under small filling pressure, it can realize that validity blocks, reduction irritates cranial nerve vascular wall;2, and sacculus position has Developing mark, the position of sacculus can be accurately positioned in doctor in interventional procedure;3, conduit itself should have preferable flexibility, Diseased region can be smoothly reached by full of twists and turns blood vessel.
Country's commercialized product is the Merci balloon guide catheters of Concentric Medical companies of U.S. production at present. Its disadvantage, which is sacculus position, does not have developing mark, doctor that can not judge the specific location of sacculus, and it is inconvenient to exist during use;Its The compliance of conduit is poor, poor by full of twists and turns vessel patency.
Therefore, those skilled in the art, which is dedicated to developing, a kind of new is used for endovascular medical treatment device.
Invention content
In view of the drawbacks described above of the prior art, new endovascular medical treatment device, institute to be used for the present invention provides a kind of Technical problems to be solved are to improve the compliance of device in the blood vessels.
To achieve the above object, the present invention provides one kind be used for endovascular medical treatment device, including slender member and Expandable capsule, the slender member include the proximal segment for being connect with handle, the distal ports for carrying the capsule and Interlude between the proximal segment and distal ports, the interlude include at least first segment, second segment and third section, institute The first segment stated, second segment, third section proximally to being distally arranged in order, the first segment, second segment and third section it is hard Degree is different from.
Preferably, described includes balloon guide catheter for endovascular medical treatment device.
Preferably, the first segment, second segment and third section abut successively.
Preferably, the hardness of the first segment, second segment and third section is sequentially reduced.
Preferably, the interlude further includes the proximal end linkage section for being connect with proximal segment, is adjacent to the first segment Proximal end, the hardness of the proximal end linkage section is more than the hardness of the first segment.
Preferably, the interlude further includes the distal end linkage section for being connect with distal ports, is adjacent to the third section Distal end, the hardness of the distal end linkage section is less than the hardness of the third section.
Preferably, the interlude includes interlude outer tube and interlude inner tube;The interlude outer tube includes interlude Outer tube first segment, interlude outer tube second segment, intermediate outer tube third section;The interlude inner tube includes interlude inner tube first Section, interlude inner tube second segment, intermediate inner tube third section;The interlude outer tube first segment and the interlude inner tube first segment The first segment of the interlude is constituted, the interlude outer tube second segment and the interlude inner tube second segment constitute the centre The second segment of section, the interlude outer tube third section and the interlude inner tube first segment constitute the third section of the interlude.
Preferably, during the interlude inner tube first segment, interlude inner tube second segment, intermediate inner tube third section include at least Between section inner tube first layer, the interlude inner tube second layer, interlude inner tube third layer, wherein the interlude inner tube first layer and The material of interlude inner tube third layer is plastics, and the material of the interlude inner tube second layer is wire braid.
Preferably, the wire braid of the interlude inner tube second layer is that netted braided fabric and/or spring-like weave Object.
Preferably, first layer, the intermediate inner tube of the first layer of the interlude inner tube first segment, interlude inner tube second segment The hardness of the first layer of third section is sequentially reduced and/or the second layer of the interlude inner tube first segment, interlude inner tube second The second layer of section, the hardness of the second layer of intermediate inner tube third section are sequentially reduced.
Preferably, the interlude outer tube first segment, interlude outer tube second segment, intermediate outer tube third section material be modeling Material.
Preferably, the interlude outer tube first segment, interlude outer tube second segment, intermediate outer tube third section hardness successively Reduce.
Preferably, during the interlude outer tube first segment, interlude outer tube second segment, intermediate outer tube third section include at least Between section outer tube first layer, the interlude outer tube second layer, interlude outer tube third layer, wherein the interlude inner tube first layer and The material of interlude inner tube third layer is plastics, and the material of the interlude inner tube second layer is wire braid.
Preferably, the wire braid of the interlude inner tube second layer is spring-like braided fabric.
Preferably, first layer, the intermediate inner tube of the first layer of the interlude inner tube first segment, interlude inner tube second segment The hardness of the first layer of third section is sequentially reduced.
Preferably, the distal ports and the interlude have the first chamber that the axis for prolonging the slender member extends and Second chamber.
Preferably, the distal ports include distal ports outer tube and distal ports inner tube, and the interlude includes interlude outer tube With interlude inner tube;First chamber includes the inner cavity of the inner cavity and interlude inner tube of the distal ports inner tube, second chamber Space and the interlude inner tube between outer wall and the inner wall of the distal ports outer tube including the distal ports inner tube Space between outer wall and the inner wall of the interlude outer tube.
Preferably, the slender member further includes proximal segment, and the proximal segment includes proximal segment outer tube and proximal segment inner tube; First chamber includes the inner cavity of the proximal segment inner tube, and second chamber includes the outer wall of the proximal segment inner tube and described close Hold the space between the inner wall of section outer tube;Described further includes the hand for being connected to the proximal segment for endovascular medical treatment device Handle.
Preferably, described to be configured to for endovascular medical treatment device, it is described when the capsule is in the second shape There is third chamber, the distal ports outer tube there is hole, the third chamber to pass through institute between the outer wall of distal ports outer tube and the capsule Hole is stated to be connected to second chamber.
Preferably, described further includes the marker that can be shown under ray for endovascular medical treatment device, it is close or It is close to the proximal end and/or distal end of the capsule.
Preferably, the marker is ring-type, is socketed in the outside of the slender member.
Preferably, the marker is developing material, is embedded into inside the cyst wall of the capsule.
The present invention advantageous effects be:The interlude of slender member is designed using the multisection type of different hardness material, The flexibility for improving the intravascular part of device, to improve ability of the device by full of twists and turns blood vessel.
The technique effect of the design of the present invention, concrete structure and generation is described further below with reference to attached drawing, with It is fully understood from the purpose of the present invention, feature and effect.
Description of the drawings
Fig. 1 is the knot of the first preferred embodiment provided by the present invention for endovascular medical treatment device Structure section schematic diagram.
Fig. 2 is the structure vertical section signal of the part interlude of the conduit shown in FIG. 1 for endovascular medical treatment device Figure.
Fig. 3 is the structure vertical section signal of the complete interlude of the conduit shown in FIG. 1 for endovascular medical treatment device Figure.
Fig. 4 is the feature cross-section schematic diagram of the interlude of the conduit shown in FIG. 1 for endovascular medical treatment device.
Fig. 5 is the structure vertical section of the distal ports and top section of the conduit shown in FIG. 1 for endovascular medical treatment device Schematic diagram (capsule is in contraction state).
Fig. 6 is the structure vertical section of the distal ports and top section of the conduit shown in FIG. 1 for endovascular medical treatment device Schematic diagram (capsule is in swelling state).
Fig. 7 is the structure vertical section of the distal ports and top section of the conduit shown in FIG. 1 for endovascular medical treatment device Schematic diagram (being encapsulated stifled blood vessel of expansion).
Fig. 8 is that the proximal segment of the conduit shown in FIG. 1 for endovascular medical treatment device and the structure vertical section of handle show It is intended to.
Fig. 9 is in second of preferred embodiment provided by the present invention for endovascular medical treatment device Between section structure vertical section schematic diagram.
Figure 10 is second of preferred embodiment provided by the present invention for endovascular medical treatment device The feature cross-section schematic diagram of interlude.
Figure 11 is the third preferred embodiment provided by the present invention for endovascular medical treatment device Structure vertical section schematic diagram.
Figure 12 is the 4th kind of preferred specific embodiment provided by the present invention for endovascular medical treatment device Structure vertical section schematic diagram.
Figure 13 is the 5th kind of preferred embodiment provided by the present invention for endovascular medical treatment device Structure vertical section schematic diagram.
Specific implementation mode
Multiple preferred embodiments that the present invention is introduced below with reference to Figure of description, keep its technology contents more clear and just In understanding.The present invention can be emerged from by many various forms of embodiments, and protection scope of the present invention not only limits The embodiment that Yu Wenzhong is mentioned.
In the accompanying drawings, the identical component of structure is indicated with same numbers label, everywhere the similar component of structure or function with Like numeral label indicates.The size and thickness of each component shown in the drawings are to be arbitrarily shown, and there is no limit by the present invention The size and thickness of each component.In order to keep diagram apparent, some places suitably exaggerate the thickness of component in attached drawing.
The term in term as used herein " proximal end " or similar description direction should be understood as:Device or component One end close to user's (or handle) or the target location of separate blood vessel to be treated;Term as used herein " distal end " Or the term in similar description direction should be understood as:The separate user (or handle) of device or component or close to needing to locate One end of the target location of the blood vessel of reason.Term as used herein " close end " should be understood as:It is leaned in device or component Close or adjacent proximal ends a parts (being not required for certain adjacent proximal ends);Term as used herein " distal portion " should be appreciated that For:Close to or close to a part for distal end (being not required for centainly close to distal end) in device or component.
Term as used herein " balloon guide catheter " should be understood as:Including elongated guiding catheter, and remote What end carried expandable capsule stretches into endoceliac device.The meaning of " guiding catheter " meaning in " balloon guide catheter " Think of is, which can be transported to target location by other medical instruments (for example, removing instrument of thrombus) or reagent, that is, Play the role of " guiding ";It should be noted that need not be by other medical instruments for directly removing obstruction, the device It itself can also implement the operation (for example, by negative-pressure ward thrombus) of removal body cavity internal congestion.Therefore, " balloon guide catheter " It is understood not to that the device of body cavity internal congestion must could be removed by other medical instruments.
Fig. 1-Fig. 6 shows that the first for endovascular medical treatment device provided by the present invention is preferably embodied Mode.
As shown in figs 1 to 6, the device in the specific implementation mode is used for from intravascular removal thrombus, object and/or resistance Plug property substance, a kind of most typical application are to remove thrombus.The device includes slender member 100, by the distal end of slender member 100 The handle 300 of the expandable capsule 200 that section carries and the proximal segment positioned at slender member.The device can in many ways into Row operation, for executing various processing functions or other functions in the blood vessels.For example, the device can be carried out with the first pattern Operation, makes the shape of the device minimize, consequently facilitating being imported to endovascular target location;The device can also be with second Pattern is operated, for example, with will go removing thrombus instrument reach target thrombi, and by remove thrombus after instrument inspiration Inner cavity;The device can also be operated with the third pattern, for example, removing blood vessel internal congestion, such as blood for directly suction Bolt;The device can also be operated with the 4th kind of pattern, for example, balloon expandable Basilar artery blood flow, and carry out angiography.
The generally elongated shape of slender member 100, including proximal segment 110, interlude 120, distal ports 130, top section 140. Interlude 120, distal ports 130 and top section 140 be sized to import it is intravascular, proximal segment 110, interlude 120, Distal ports 130, top section 140 have the first interconnected chamber 510 extended along its axis.First chamber 510 is for directly inhaling It takes and removes blood vessel internal congestion, such as thrombus, or target site is sent to the instrument that will remove obstruction, and after obstruction being removed Instrument sucks, or passes through channel for other instruments.
As shown in Fig. 2, interlude 120 includes the interlude outer tube 121 extended along same axis and interlude inner tube 122, First chamber 510 is the inner cavity of interlude inner tube 122.Have along interlude between interlude outer tube 121 and interlude inner tube 122 The second chamber 520 that 120 axis extends.Device in the specific implementation mode is mainly used for removing the thrombus of intracranial vessel, because This, the length of interlude 120 can be 30 centimetres -160 centimetres, and the outer diameter of interlude outer tube 121 can be 1.5 millimeter of -4.0 milli The diameter of rice, the first chamber 510 can be 0.8 millimeter -3.5 millimeters.In view of interlude outer tube 121 and interlude inner tube 122 The space of necessary thickness and the second enough chamber 520, the internal diameter (i.e. the outer diameter of the second chamber 520) of interlude outer tube 121 can be with It it is 1.45-3.95 millimeters, the outer diameter (i.e. the internal diameter of the second chamber 520) of interlude inner tube 122 can be 1.43-3.93 millimeters.
The main function of interlude 120 is the target location that distal ports 130 and top section 140 are delivered to blood vessel, and The second chamber 520 is provided to transmit the pressure for making capsule 200 expand, therefore the configuration of interlude 120 mainly considers its mechanical property.
As shown in figure 3, the interlude of the slender member 100 for endovascular medical treatment device in the specific implementation mode Outer tube 121 and interlude inner tube 122 are all divided into five sections.Interlude outer tube 121 divides proximally to extend to distal end and abut successively 's:Interlude proximal outer tube linkage section 1214, interlude outer tube first segment 1211, interlude outer tube second segment 1212, centre are outer Pipe third section 1213, interlude distal outer tube linkage section 1215.Wherein, interlude proximal outer tube linkage section 1214 and proximal segment 110 outer tube connection, interlude distal outer tube linkage section 1215 are connect with the outer tube of distal ports 130.Interlude inner tube 122, which is divided, is Proximally to distal end extend and successively abut:Interlude inner tube proximal end linkage section 1224, interlude inner tube first segment 1221, in Between section inner tube second segment 1222, intermediate inner tube third section 1223, interlude inner tube distal end linkage section 1225.Wherein, in interlude Pipe proximal end linkage section 1224 is connect with the inner tube of proximal segment 110, and interlude inner tube distal end linkage section 1225 is interior with distal ports 130 Pipe connects.
In this specific embodiment, interlude proximal outer tube linkage section 1214 and interlude inner tube proximal end linkage section 1224 Length it is consistent, constitute the proximal end linkage section of entire interlude 120;Interlude outer tube first segment 1211 and interlude inner tube One section 1221 of length is consistent, constitutes the first segment of entire interlude 120;In interlude outer tube second segment 1212 and interlude The length of pipe second segment 1222 is consistent, constitutes the second segment of entire interlude 120;In intermediate outer tube third section 1213 and centre The length of pipe third section 1223 is consistent, constitutes the third section of entire interlude 120;1215 He of interlude distal outer tube linkage section The length of interlude inner tube distal end linkage section 1225 is consistent, constitutes the distal end linkage section of entire interlude 120.Entire interlude 120 proximal end linkage section, first segment, second segment, third section, the hardness of distal end linkage section are sequentially reduced.Wherein, second segment, Three sections of major parts for being to provide desired compliance, typically for the application for typically removing removing thrombus, second segment and third The length of section is respectively about 40-60mm, it is further preferred that the length of second segment and third section is respectively 48-52mm.Proximal end connects It connects section and first segment is to provide the desired major part for turning round control property, typically for the application for typically removing removing thrombus, proximal end The length of linkage section is about 80-120mm, it is further preferred that the length of proximal end linkage section is about 90-110mm;First segment Length configures as needed.
The inventors of the present application found that in the device of existing similar balloon guide catheter, the mechanical property of interlude Ideal effect is often not achieved, compliance is poor, poor by full of twists and turns vessel patency, is brought greatly to operation It is inconvenient.If with single material be made interlude outer tube and inner tube or be difficult to realize desired compliance (be convenient for Predetermined position is reached by curved blood vessel) and property (adjustment direction when person easy to operation uses) is controlled in torsion or material expensive arrives It can not popularize.In this specific embodiment, present inventor creatively proposes a kind of new solution, that is, uses Material of the composite layer including braided fabric as interlude inner tube 122.
Fig. 4 shows the cross section of interlude inner tube 122, interlude inner tube proximal end linkage section 1224, interlude inner tube One section 1221, interlude inner tube second segment 1222, intermediate inner tube third section 1223, interlude inner tube distal end linkage section 1225 all adopt With structure shown in Fig. 4.As shown in figure 4, interlude inner tube 122 is divided into three layers from outside to inside, respectively:Interlude inner tube first Layer 1227, the interlude inner tube second layer 1228, interlude inner tube third layer 1229, wherein 1227 He of interlude inner tube first layer The material of interlude inner tube third layer 1229 is plastics, and the material of the interlude inner tube second layer 1228 is wire braid.
In this specific embodiment, the weaving manner of wire fabric used by the interlude inner tube second layer 1228 For netted braiding, (in general, if other parameters are identical, netted braided fabric is harder than spring-like braided fabric with spring-like braided fabric; Spring-like braided fabric has better flexibility, is conducive to curved.And for identical weaving manner, braided wires size is bigger, compiles Fabric is then harder;Netted count is bigger, then braided fabric is harder, i.e., mesh is smaller harder, that is, the numerical value of ppi is bigger, Braided fabric is harder;For spring-like braided fabric, the distance of adjacent filaments is closer, and braided fabric is harder), wire is (for example, stainless steel Silk) braided fabric after braiding can provide desired basic hardness as needed.In general, for desired torsion control property And compliance, the hardness of interlude inner tube proximal end linkage section 1224 is relatively large, and in interlude inner tube second segment 1222, centre Pipe third section 1223, the hardness of interlude inner tube distal end linkage section 1225 are relatively small, in order to realize desired hardness gradually The purpose of change, can be at least there are three types of mode.First way is the gradual change of hardness to be realized in the second layer, using different thicknesses Wire or using the wire of unlike material or using different netted counts or use different weaving manners (for example, using netted weaving manner in proximal end, spring-like weaving manner is used in distal end), can realize the mesh of hardness gradient 's;The second way is the gradual change of hardness to be realized in first layer, for example, using the different plastics of hardness;The third mode is, The combination of first way and the second way, for example, the metal mesh shaped braided fabric that the second layer uses hardness different, meanwhile, First layer is using the different plastics of hardness.Present inventor is intermediate it was unexpectedly observed that a preferred embodiment is The first layer of section inner tube proximal end linkage section 1224 uses nylon, the first layer of interlude inner tube first segment 1221 to use Pebax7233, the first layer of interlude inner tube second segment 1222 use Pebax5533, and the of interlude inner tube third section 1223 One layer uses Pebax4033, the first layer of interlude inner tube distal end linkage section 1225 to use Pebax2533, such configuration Ideal torsion control and compliance can be obtained, meanwhile, first layer has the function of support and anti-folding.Interlude inner tube Polytetrafluoroethylene (PTFE) (PTFE) may be used in three layer 1229 of material, reduces the frictional force of inner wall in this way, enables other instrument more Small resistance passes through.A kind of preferred embodiment is that the material of interlude inner tube third layer 1229 uses PTFE WT0.025, i.e. wall thickness are the PTFE of 0.025mm.
In this specific embodiment, interlude proximal outer tube linkage section 1214, interlude outer tube first segment 1211, centre Section outer tube second segment 1212, intermediate outer tube third section 1213, the material of interlude distal outer tube linkage section 1215 all use plastics, For example, using Pebax.The main function of interlude outer tube is support and anti-folding, in this way, interlude proximal outer tube linkage section 1214, interlude outer tube first segment 1211, interlude outer tube second segment 1212, intermediate outer tube third section 1213, interlude outer tube The identical Pebax of hardness may be used in distal end linkage section 1215.As a preferred solution, interlude proximal outer tube linkage section 1214, interlude outer tube first segment 1211, interlude outer tube second segment 1212, intermediate outer tube third section 1213, interlude outer tube The different Pebax of hardness may be used in distal end linkage section 1215, further to strengthen the performance of the hardness gradient of interlude.This Shen Please inventor it was unexpectedly observed that a preferred embodiment is, interlude proximal outer tube linkage section 1214 uses nylon, Interlude outer tube first segment 1211 uses Pebax7233, interlude outer tube second segment 1212 to use Pebax5533, intermediate outer tube Third section 1213 uses Pebax4033, interlude distal outer tube linkage section 1215 to use Pebax2533, such configuration can be with Ideal torsion control and compliance are obtained, meanwhile, ideal support and anti-folding are provided.
As shown in figure 5, distal ports 130 include distal ports outer tube 131 and distal ports inner tube 132, the first chamber 510 is distal ports The inner cavity of inner tube 132, that is to say, that the first chamber 510 extends to distal ports 130 along its axis from interlude 120.Distal ports outer tube There is the second chamber 520 that the axis of distally section 130 extends, that is to say, that the second chamber 520 between 131 and distal ports inner tube 132 Along its axis distal ports 130 are extended to from interlude 120.Expandable capsule 200 is located at the outside of distal ports outer tube 131.As The outer diameter of a kind of preferred mode, distal ports outer tube 131 can be suitably less than the outer diameter of interlude outer tube 121, in this way, working as capsule 200 when shrinking, and the outer diameter of the outer diameter in the capsule portion of device and entire endovascular part is the same or smaller, convenient for the stream of blood It moves in the blood vessels logical and device intravascular part.Distal ports outer tube 131 and distal ports inner tube 132 may be used and interlude 1225 identical material of distal outer tube linkage section 1215 and interlude inner tube distal end linkage section, for example, outside directly as interlude The extended segment of pipe distal end linkage section 1215 and interlude inner tube distal end linkage section 1225;Distal ports outer tube 131 and distal ports inner tube 132 can also use the material with interlude distal outer tube linkage section 1215 and interlude inner tube distal end linkage section 1225, for example, Compared to interlude distal outer tube linkage section 1215 and interlude inner tube distal end linkage section 1225, distal ports outer tube 131 and distal ports Inner tube 132 uses more rigid material.These are also all technologies known in the art, and this will not be detailed here.
Fig. 5-Fig. 7 shows the distal ports 130 and capsule 200 of the slender member 100 in the specific implementation mode.In figure 3, Capsule 200 is in the first shape of contraction state;In Fig. 4, capsule 200 is in the second shape of swelling state;In Figure 5, capsule 200 The second shape in swelling state, and block blood vessel.
As shown in Figure 5 and Figure 6, capsule 200 includes proximal end interconnecting piece 210, distal connection 220 and inflatable portion 230.Proximal end The effect of interconnecting piece 210 and distal connection 220 is exactly to be connected with distal ports 130 and/or top section 140 so that third chamber 530 Relative to the outer closures of capsule 200, so that inflatable portion 230 is expanded under the effect of the pressure.The proximal end interconnecting piece of capsule 200 210 and the connection type of distal connection 220 and distal ports 130 and/or top section 140 can there are many, for example, can be by viscous Mixture bonding, interference fit, laser welding, sound wave welding, melting, closely noose, by other connectors (such as lock ring, Wire or high score sub-line bind) it is closely bonded or/and the modes such as adhesive bonding is coordinated to be attached.
Capsule 200 by medial surface pressure when it is inflatable, that is to say, that capsule 200 at least have that there are two types of shapes, that is, is in receipts The first shape (Fig. 5) of contracting state and the second shape (Fig. 6 and Fig. 7) in swelling state.When capsule 200 is in first shape When, slender member 100 and capsule 200 are suitble to move in the blood vessels as a whole;When capsule 200 is in the second shape, capsule 200 plays Block the effect of blood vessel.
When capsule 200 is in swelling state, inflatable portion 230 is with having third chamber 530 between distal ports outer tube 131.The It is connected to by one or more holes 133 on distal ports outer tube 131 between three chambers 530 and the second chamber 520 so that come from handle 300 pressure is transmitted to bulge 230 between distal ports outer tube 131 by the second chamber 520 so that capsule 200 carry out it is swollen It is swollen.The pressure that capsule 200 is expanded is allow to be hydraulic pressure or air pressure, preferably hydraulic pressure (such as developer or physiological saline). Capsule 200 can be made up of single tubular material of molding, blowing or other means.The proximal end interconnecting piece 210 of capsule 200 and distal end Interconnecting piece 220 can be sufficiently thick and/or rigid sufficiently strong, to provide enough sealing functions;And inflatable portion 230 can compare Proximal end interconnecting piece 210 and distal connection 220 are made thinner, shape when in order to provide desired expansion.Alternatively, capsule 200 Proximal end interconnecting piece 210, distal connection 220 and inflatable portion 230 or same thickness also may be used in this case To provide the shape of desired expansion.
Capsule 200 can be made of elastic material, such as compliance or semi-compliant capsule.Compliance or semi-compliant capsule can be with It is launched into sizes and/or shape according to the amount of the fluid in third chamber 530 and/or pressure.Capsule 200 can also be by basic Inelastic material is made, for example, non-compliance capsule, unfolded to predetermined size when inflated, it is unrelated with pressure (to work as addition Minimum volume and/or pressure are come after reaching predetermined size).One benefit of non-compliance capsule is, even if using relatively high pressure Power, capsule 200 expand when be not more than predetermined size, just not will produce in this way it is to blood vessel it is not expected that stronger pressure Compel.One benefit of compliance capsule is that, when the pressure for making capsule 200 expand is released, capsule 200, which may be collapsed to, is close to distal ports The outer wall of outer tube 131 so that the outer diameter in the capsule portion of whole device is as small as possible, convenient for the blood vessel of the circulation and device of blood Inside points move in the blood vessels.The preferred compliance capsule of the specific implementation mode, such as be made of the materials such as silica gel, PU, TPU.
As shown in Figure 6 and Figure 7, in this specific embodiment, when the inflatable portion 230 of capsule 200 is in swelling state, Capsule 200 is fitted closely with blood vessel 400, to block blood vessel.
In this specific embodiment, which further includes marker 240.The effect of marker 240 be ray (such as X-ray) under show that the preferable or more stable metal or metal alloy of biocompatibility, example can be selected in the position of capsule 200, material Such as platinum group metal (such as platinumiridio), gold are addition developing material (such as barium salt (BaSO4), bismuth salt (BiOCl) Deng) high molecular material.Alternatively, can also capsule 200 material may be addition developing material (such as barium salt (BaSO4), bismuth Salt (BiOCl etc.) etc.) high molecular material.
In this specific embodiment, as shown in Figures 6 and 7, marker 240 is ring-type, is socketed on distal ports outer tube 131 Outer wall, also, marker 240 is between capsule 200 and distal ports outer tube 131, that is to say, that when capsule 200 is in expansion shape body When, marker 240 is located at the inside of third chamber 530.It will be apparent that the deformation as the specific implementation mode, is socketed on distal ports The cricoid marker 240 of the outer wall of outer tube 131 can also be located at the outside of third chamber 530, for example, the position other than capsule 200 It sets.Alternatively, marker 240 can also directly be socketed on capsule 200 proximal end interconnecting piece 210 and/or distal connection 220 it is outer Face, in this case, marker 240 are also used as lock ring, help between capsule 200 and the outer wall of distal ports outer tube 131 Closed connection.Either it is located at the outside of third chamber 530, or positioned at the inside of third chamber 530, marker 240 is preferably both Both ends that are close or being close to capsule 200, that is to say, that close or be close to proximal end interconnecting piece 210 and distal connection 220.In the tool In body embodiment, there are two ring-shaped mark objects 240 altogether, are close to proximal end interconnecting piece 210 and distal connection 220 respectively.This The configuration of sample can most clearly show the position of capsule 200 under ray.It will be apparent that the deformation as the specific implementation mode, Ring-shaped mark object 240 can also be arranged more, for example, corresponding position configures ring at its maximum outside diameter when capsule 200 expands Shape marker.
As shown in figure 5, in this specific embodiment, top section 140 has the first chamber 510, that is to say, that the first chamber 510 extend to top section 140 along its axis from distal ports 130.Distal end namely the first chamber of first chamber 510 of top section 140 510 openings towards internal tube, thrombus and/or other instruments for removing thrombus just pass in and out the first chamber 510 from the opening. The top for functioning as slender member 100 of top section 140, proximal end and distal ports outer tube 131 and distal ports inner tube 132 Distal end connection.The material preferred hardness of top end part 140 is smaller but has the material of certain elasticity;To be pushed away in slender member There is better protection to blood vessel when entering the bending section in blood vessel;Specific material such as Pebax2533, Pebax3533, TPU3585A and TPU3595A etc..In order to allow operator that can judge that the position of the device in the blood vessels, top end part 140 also may be used With setting flag object, such as metal or metal alloy that biocompatibility said before is preferable or more stable, such as platinum family Metal (such as platinumiridio), gold or the material of top end part 140 are addition developing material (such as barium salt (BaSO4), bismuth salt (BiOCl etc.) etc.) high molecular material.When the manufacturing, top section 140 and distal ports outer tube 131 and/or distal ports inner tube 132 can be manufactured separately, and be then connected to together;Top section 140 and distal ports outer tube 131 and/or distal ports inner tube 132 can also manufacture integrally.
As shown in figure 8, in this specific embodiment, proximal segment 110 includes proximal segment outer tube 111 and proximal segment inner tube 112, the first chamber 510 is the inner cavity of proximal segment inner tube 112, that is to say, that along its axis, proximally section 110 extends the first chamber 510 To interlude 120.There is the second chamber that the axis along proximal segment 110 extends between proximal segment outer tube 111 and proximal segment inner tube 112 520, that is to say, that along its axis, proximally section 110 extends to interlude 120 to the second chamber 520.
The main function of proximal segment 110 is exactly to connect handle 300, and provide the first chamber 510 from handle 300 and the The channel of two chambers 520.As shown in fig. 6, handle is used to holding and operating whole device, for example, by slender member 100 and capsule 200 It is pushed to endovascular target location.Handle at least has there are two mutually isolated chamber, a chamber and the first of slender member 100 Chamber 510 is connected to, for removing thrombus;Another chamber is connected to the second chamber 520 of slender member 100, is made for providing pressure Capsule 200 expands and removal pressure makes capsule 200 shrink.In order to complete this function, handle 300 need by interface in addition Device connection, for example, generating the device (such as syringe, full device, vacuum pump, be used for the first chamber 510) of negative pressure and carrying For hydraulic pressure or the device of air pressure (such as syringe, full device etc. be used for the second chamber 520).The configuration of proximal segment 110 and handle 300 It is all technology known in the art, this will not be detailed here.
Can directly be stretched into from skin through puncture or notch for endovascular medical treatment device in the specific implementation mode It is intravascular, alternatively, the device also using one or more other instruments enter it is intravascular, for example, guide sheath (leading by conduit and capsule Draw and pass through inside sheath or guide sheath is passed through in the first intracavitary of conduit), (conduit and capsule pass through guide wire outside guide wire, lead Draw silk and be located at the first intracavitary).The position that marker 240 is monitored under the irradiation of ray promotes injection after reaching target location Device provides hydraulic pressure or air pressure makes capsule 200 expand and block blood vessel, and remove the operation of thrombus, for example, opening vacuum pump Aspirate thrombi.After completing suction, pumpback syringe makes the liquid in the second chamber 520 or gas backstreaming, to make capsule 200 receive Contracting.Finally by whole device from intravascular extraction.It in the process, can also be by 510 delivery of therapeutic agents of the first chamber to intravascular Target location, alternatively, conveying for directly removal thrombus other instruments.
Fig. 9 and Figure 10 shows second of preferred specific reality provided by the present invention for endovascular medical treatment device Apply mode.
Device in the specific implementation mode is identical as the capsule 200 of the first specific implementation mode and the structure of handle 300, Primary difference is that the structure of slender member 100.
In this specific embodiment, slender member 100 equally also includes proximal segment 110, interlude 120, distal ports 130, top section 140.Proximal segment 110, interlude 120, distal ports 130 equally include inner and outer tubes, equally also have first Chamber 510 and the second chamber 520.Interlude outer tube 121 and interlude inner tube 122 are equally all divided into five sections.Interlude outer tube 121, which divides, is Proximally to distal end extend and successively abut:Interlude proximal outer tube linkage section 1214, interlude outer tube first segment 1211, in Between section outer tube second segment 1212, intermediate outer tube third section 1213, interlude distal outer tube linkage section 1215.Interlude inner tube 122 Be divided into proximally to distal end extend and successively abut:Interlude inner tube proximal end linkage section 1224, interlude inner tube first segment 1221, interlude inner tube second segment 1222, intermediate inner tube third section 1223, interlude inner tube distal end linkage section 1225.
The structure of interlude inner tube 122 in the specific implementation mode is identical as the first specific implementation mode, different It is the structure of interlude outer tube 121.
Figure 10 shows the cross section of the interlude outer tube 121 in the specific implementation mode, the connection of interlude proximal outer tube Section 1214, interlude outer tube first segment 1211, interlude outer tube second segment 1212, intermediate outer tube third section 1213, outside interlude Pipe distal end linkage section 1215 all uses structure shown in Fig. 10.As shown in Figure 10, interlude outer tube 121 is divided into three from outside to inside Layer, respectively:Interlude outer tube first layer 1217, the interlude outer tube second layer 1218, interlude outer tube third layer 1219, In, the material of interlude outer tube first layer 1217 and interlude outer tube third layer 1219 is plastics, the interlude outer tube second layer 1218 material is wire braid.
It is therefore, in this specific embodiment, intermediate because the main function of interlude outer tube is to provide support and anti-folding The weaving manner of wire fabric used by the section outer tube second layer 1218 is non-mesh braiding, a kind of preferred embodiment It is spring-like braiding, i.e. braided fabric is mainly made of spring-like metal silk (for example, stainless steel wire) crosslinking.Interlude outer tube first The identical plastics of hardness, such as Pebax, the plastics that hardness can also be used different may be used in layer 1217.A kind of preferred implementation Scheme is using the different plastics of hardness, and the first layer of interlude proximal outer tube linkage section 1214 uses nylon, interlude outer tube The first layer of first segment 1211 uses Pebax7233, the first layer of interlude outer tube second segment 1212 to use Pebax5533, in Between the first layer of section outer tube third section 1213 use Pebax4033, the first layer of interlude distal outer tube linkage section 1215 adopts With Pebax2533, such configuration can further strengthen the performance of the hardness gradient of interlude.Interlude outer tube third layer Polytetrafluoroethylene (PTFE) (PTFE) may be used in 1219 material, reduces the frictional force of inner wall in this way.A kind of preferred specific embodiment party Case is that PTFE WT0.025 may be used in the material of interlude inner tube third layer 1219.
Figure 11 shows the third preferred specific embodiment party provided by the present invention for endovascular medical treatment device Formula.
Device in the specific implementation mode and the slender member 100 of the first specific implementation mode and the knot of handle 300 Structure is identical, primary difference is that the structure of capsule 200.
In this specific embodiment, equally also there are two types of shapes for tool for capsule 200, that is, are in the first shape of contraction state (not shown) and the second shape (Fig. 7) in swelling state.Similarly, when capsule 200 is in first shape, elongated structure Part 100 and capsule 200 are suitble to move in the blood vessels as a whole;When capsule 200 is in the second shape, capsule 200 plays closure blood vessel Effect.
It as shown in figure 11, in this specific embodiment, can when the inflatable portion 230 of capsule 200 is in swellable state Bulge 230 has the position that blood vessel can be blocked at two.Because blocking the outer surface mainly by inflatable portion 230 and blood vessel 400 fit closely to realize, therefore, inflatable portion 200 has be close to and block blood vessel with vascular wall first to block appearance Face 231 and for be close to vascular wall and block blood vessel second block outer surface 232, first block outer surface 231 and second Block outer surface 232 be separated from each other in position, that is to say, that first block outer surface 231 and second block outer surface 232 with There is the 4th chamber 540 between the blood vessel 400 being close to.The shape of capsule 200 generally Pear-Shaped shown in Figure 11.It is so-called " Pear-Shaped " refers to be, from the appearance, there are two the parts of sphere or approximate spheres for the main body of capsule 200.The capsule of Pear-Shaped exists It may be more prone to than other shapes in manufacture, it will be clear that according to the principle that the specific implementation mode provides, capsule 200 can also For other shapes.For example, first block outer surface 231 and second block outer surface 232 closer to plane rather than spherical surface.
Relative to the first specific implementation mode, the device in the specific implementation mode utilizes mutually to be divided in position at two The position opened blocks blood vessel, and benefit is to mitigate the compressing and stimulation to blood vessel, to reduce the generation of complication.
For example, one kind typically, needs to handle the internal diameter of the blood vessel of thrombus to be about 6mm.In existing skill In art, capsule 200 only has position at one to block blood vessel, for example, coming from shape, there are one spheres for entire capsule 200.This In the case of, in order to reach desired plugging effect, when capsule is in the second shape of expansion, the outer diameter of capsule would generally reach The length of 7mm or so, capsule would generally reach 8mm or so, and the area for blocking face is usually 311mm2Left and right.
In this specific embodiment, blood vessel is blocked using position at two, than one at the efficiency that blocks of position improve Very much, the outer diameter, width and area that closure face can be greatly reduced in this way, to greatly reduce the pressure to blood vessel It forces to make peace stimulation.Present inventor it was unexpectedly observed that for be about typically 6mm vessel diameter, when capsule 200 be expanded into it is outer When diameter is 7mm, if configuring the length of capsule 200 to 10-14mm can be realized ideal plugging effect.At this moment, it first blocks The area that outer surface 231 and second blocks one in outer surface 232 is about 100~160mm2.Present inventor is into one Step is found, for the blood vessel of internal diameter bigger, for example, when it is 9mm that capsule 200, which is expanded into outer diameter, if the length of capsule 200 configured For 10-16mm, you can realize ideal plugging effect;When it is 10mm that capsule 200, which is expanded into outer diameter, if by the length of capsule 200 It is configured to 10-18mm, you can realize ideal plugging effect.In the prior art, a certain company of face vascular compression is individually blocked Continuous position, it is larger to vascular stimulation;And multiple bag pressures compel the different location in blood vessel, reduce the continued stimulus to blood vessel, reduce Blood vessel stress reaction, to reduce complication.
For compliance capsule, it is desirable to be expanded into desired Pear-Shaped, can configure capsule 200 makes the dilatancy at in-between position It is poor, for example, the wall at intermediate position is thicker, alternatively, using the poor material of dilatancy, develop alternatively, being embedded at intermediate position Material (such as barium salt (BaSO4), bismuth salt (BiOCl etc.) etc.) etc..
Figure 12 shows the 4th kind of preferred specific embodiment party provided by the present invention for endovascular medical treatment device Formula.
Device in the specific implementation mode and the slender member 100 of the third specific implementation mode and the knot of handle 300 Structure is identical, primary difference is that the structure of capsule 200.
In this specific embodiment, capsule 200 equally also has the first closure for being close to and blocking blood vessel with vascular wall outer Surface 231 and for be close to vascular wall and block blood vessel second block outer surface 232, in the first specific implementation mode The shape and size that outer surface 232 is blocked in relation to the first closure outer surface 231 and second provided are also applied for the specific reality Apply mode.
With the first specific implementation mode the difference is that the capsule 200 in the specific implementation mode divides for the first capsule portion 201 With the second capsule portion 202.Wherein, the first closure outer surface 231 is located at the first capsule portion 201, and second, which blocks outer surface 232, is located at second Capsule portion 202.When the first capsule portion 201 is in swelling state, the first capsule portion 201 is with having third chamber between distal ports outer tube 131 First point of chamber 531;When the second capsule portion 202 is in swelling state, the second capsule portion 202 is with having the between distal ports outer tube 131 Three chambers second divide chamber 532.Third chamber first is divided to chamber 531 and third chamber second that chamber 532 is divided to be independent from each other two chambers, also It says, third chamber first is divided chamber 531 and third chamber second that chamber 532 is divided closely to be isolated by the first capsule portion 201 and the second capsule portion 202 Two chambers.Third chamber first divides between chamber 531 and the second chamber 520 to be connected to by the hole on distal ports outer tube 131, third chamber second Divide between chamber 532 and the second chamber 520 and be connected to also by the other hole on distal ports outer tube 131 so that comes from handle 300 Pressure is transmitted to bulge 230 between distal ports outer tube 131, so that the first capsule portion 201 and second by the second chamber 520 Capsule portion 202 is expanded.Therefore, referring to " third chamber first divides chamber and third chamber second to divide chamber mutual indepedent " mentioned here and Be not be not connected between third chamber first divides chamber and third chamber second to divide chamber (they are connected to indirectly by the second chamber 520), and It is for capsule 200 itself, third chamber first is divided to chamber and third chamber second that the wall of chamber tunica is divided to be divided into two independent chambers.Make It equally can be hydraulic pressure or air pressure, preferably air pressure to obtain the pressure that the first capsule portion 201 and the second capsule portion 202 are expanded.
Capsule 200 is divided into a benefit in the first capsule portion 201 and the second capsule portion 202 is, manufacture is relatively easy.At the first In specific embodiment, the generally Pear-Shaped of capsule 200, when capsule 200 is in contraction state, capsule 200 is tight as far as possible It pastes the outer wall of distal ports outer tube and makes the outer diameter of capsule 200 as small as possible, to move in the blood vessels;When capsule 200 is in swollen When swollen state, capsule 200 should be expanded into desired Pear-Shaped;It realizes this point, either uses elastic material or non-ballistic Property material, cost of manufacture are generally relatively high.In this specific embodiment, capsule 200 is separated out 201 He of independent first capsule portion Second capsule portion 202, in the expanded state, the first capsule portion 201 and the second capsule portion 202 only need to be expanded into almost spherical, Realize that this point is easily more than the first specific implementation mode.During fabrication, the first capsule portion 201 and the second capsule portion 202 can To be manufactured separately, it is then respectively connected to the outer wall of distal ports outer tube.Also it just says, the first capsule portion 201 and the second capsule portion 202 are respectively provided with respective proximal end interconnecting piece, distal connection and inflatable portion.In this case, the first capsule portion 201 and Two capsule portions 202 can be considered as two independent capsules in fact.First capsule portion 201 and the second capsule portion 202 can also be manufactured into one Body, and it is coupled together to the outer wall of distal ports outer tube.Also it just says, the first capsule portion 201 and the second capsule portion 202 are as a whole With proximal end interconnecting piece, distal connection, middle interconnecting piece (the first capsule portion 201 and the second capsule portion 202 share), the first capsule portion The bulge of bulge and the second capsule portion.First capsule portion 201 and the second capsule portion 202 and the connection of distal ports outer tube can also use The mode that the first specific implementation mode is provided, for example, can be welded, be melted by adhesive bonding, interference fit, sound wave, Closely noose, the modes such as be closely bonded by other connectors and be attached.
It is identical as the first specific implementation mode, the distal ports of the slender member 100 of the device in the specific implementation mode 130 also carry marker 240.Marker 240 is also ring-type, is socketed on the outer wall of distal ports outer tube 131.In the specific implementation In mode, marker 240 is all located at the outside in capsule 200 (including the first capsule portion 201 and second capsule portion 202) there are three having altogether, In two markers 240 be close to capsule 200 proximally and distally, another marker 240 is located at the first capsule portion 201 and the second capsule portion 202 centre position can clearly illustrate the position in the first capsule portion 201 and the second capsule portion 202 under ray in this way.
Figure 13 shows the 5th kind of preferred specific embodiment party provided by the present invention for endovascular medical treatment device Formula.
In the specific implementation mode for the thin of endovascular medical treatment device and the third preferred embodiment The structure of long component 100 and handle 300 is identical, primary difference is that the structure of marker 240 and position.
In this specific embodiment, marker 240 is developing material (such as barium salt (BaSO4), the bismuth salt of strip (BiOCl etc.) etc.), it is embedded into inside the cyst wall of capsule 200.When capsule 200 expands, marker 240 and then expands together.It is such Mark mode is obviously more advantageous to position and the swelling state that operator observes capsule 200.
It will be apparent that the device provided in above-mentioned 4th kind of specific implementation mode can also be deformed in this way, i.e., Developing material is embedded into inside the cyst wall of capsule 200, this will not be detailed here.

Claims (10)

1. one kind being used for endovascular medical treatment device, including slender member and expandable capsule, the slender member includes using In the proximal segment being connect with handle, the distal ports for carrying the capsule and between the proximal segment and distal ports Between section, which is characterized in that the interlude include at least first segment, second segment and third section, the first segment, second segment, Proximally to being distally arranged in order, the hardness of the first segment, second segment and third section is different from third section.
2. being used for endovascular medical treatment device as described in claim 1, which is characterized in that described is used for endovascular medical treatment Device includes balloon guide catheter.
3. being used for endovascular medical treatment device as described in claim 1, which is characterized in that the first segment, second segment and Third section abuts successively.
4. being used for endovascular medical treatment device as described in claim 1, which is characterized in that the first segment, second segment and The hardness of third section is sequentially reduced.
5. as described in claim 1 be used for endovascular medical treatment device, which is characterized in that the interlude further include for The proximal end linkage section of proximal segment connection, is adjacent to the proximal end of the first segment, and the hardness of the proximal end linkage section is more than described the One section of hardness.
6. as described in claim 1 be used for endovascular medical treatment device, which is characterized in that the interlude further include for The distal end linkage section of distal ports connection, is adjacent to the distal end of the third section, and the hardness of the distal end linkage section is less than described the Three sections of hardness.
7. being used for endovascular medical treatment device as described in claim 1, which is characterized in that the interlude includes outside interlude Pipe and interlude inner tube;The interlude outer tube includes interlude outer tube first segment, interlude outer tube second segment, intermediate outer tube the Three sections;The interlude inner tube includes interlude inner tube first segment, interlude inner tube second segment, intermediate inner tube third section;It is described Interlude outer tube first segment and the interlude inner tube first segment constitute the first segment of the interlude, the interlude outer tube Two sections and the interlude inner tube second segment constitute the second segments of the interlude, the interlude outer tube third section and it is described in Between section inner tube first segment constitute the third section of the interlude.
8. being used for endovascular medical treatment device as claimed in claim 7, which is characterized in that the interlude inner tube first segment, Interlude inner tube second segment, intermediate inner tube third section include at least interlude inner tube first layer, the interlude inner tube second layer, centre Section inner tube third layer, wherein the material of the interlude inner tube first layer and interlude inner tube third layer is plastics, the centre The material of the section inner tube second layer is wire braid.
9. being used for endovascular medical treatment device as described in claim 1, which is characterized in that the distal ports and the interlude The first chamber and the second chamber extended with the axis for prolonging the slender member.
10. being used for endovascular medical treatment device as described in claim 1, which is characterized in that described is used for endovascular doctor It further includes the marker that can be shown under ray to treat device, proximal end and/or distal end close or that be close to the capsule.
CN201810064436.5A 2018-01-23 2018-01-23 One kind being used for endovascular medical treatment device Pending CN108309383A (en)

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109620351A (en) * 2018-12-31 2019-04-16 邓萍 A kind of thrombus dredge for medical operating
CN109701140A (en) * 2018-12-29 2019-05-03 先健科技(深圳)有限公司 Foley's tube and its lancing system
CN113855992A (en) * 2020-06-30 2021-12-31 微创神通医疗科技(上海)有限公司 A catheter
WO2022002280A1 (en) * 2020-06-30 2022-01-06 微创神通医疗科技(上海)有限公司 Catheter
WO2022127536A1 (en) * 2020-12-17 2022-06-23 微创神通医疗科技(上海)有限公司 Medical catheter and preparation method therefor

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US20120265233A1 (en) * 2009-08-28 2012-10-18 Lea Waisman Inverted balloon neck on catheter
US20160114125A1 (en) * 2014-10-27 2016-04-28 Qxmedical, Llc Variable Stiffness Balloon Catheter and Related Systems and Methods
CN208511116U (en) * 2018-01-23 2019-02-19 上海心玮医疗科技有限公司 One kind being used for endovascular medical device

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US20020026145A1 (en) * 1997-03-06 2002-02-28 Bagaoisan Celso J. Method and apparatus for emboli containment
US20120265233A1 (en) * 2009-08-28 2012-10-18 Lea Waisman Inverted balloon neck on catheter
US20160114125A1 (en) * 2014-10-27 2016-04-28 Qxmedical, Llc Variable Stiffness Balloon Catheter and Related Systems and Methods
CN208511116U (en) * 2018-01-23 2019-02-19 上海心玮医疗科技有限公司 One kind being used for endovascular medical device

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109701140A (en) * 2018-12-29 2019-05-03 先健科技(深圳)有限公司 Foley's tube and its lancing system
CN109701140B (en) * 2018-12-29 2022-04-22 先健科技(深圳)有限公司 Balloon catheter and puncture system thereof
CN109620351A (en) * 2018-12-31 2019-04-16 邓萍 A kind of thrombus dredge for medical operating
CN113855992A (en) * 2020-06-30 2021-12-31 微创神通医疗科技(上海)有限公司 A catheter
WO2022002280A1 (en) * 2020-06-30 2022-01-06 微创神通医疗科技(上海)有限公司 Catheter
WO2022127536A1 (en) * 2020-12-17 2022-06-23 微创神通医疗科技(上海)有限公司 Medical catheter and preparation method therefor

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