CN108309291A - A kind of flexible contact electrode for encephalograms and preparation method thereof - Google Patents

A kind of flexible contact electrode for encephalograms and preparation method thereof Download PDF

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CN108309291A
CN108309291A CN201810198860.9A CN201810198860A CN108309291A CN 108309291 A CN108309291 A CN 108309291A CN 201810198860 A CN201810198860 A CN 201810198860A CN 108309291 A CN108309291 A CN 108309291A
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陈炜
陶林锴
陈晨
袁伟
崔铮
王泽宇
李巍
袁心宇
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Abstract

The invention belongs to electrophysiologicalsignal signal detection technical field, specially a kind of flexible electrode for encephalograms and preparation method thereof.Electrode for encephalograms is made of flexible silicon gel electrode piece and electrode base.Flexible silicon gel electrode piece upper layer is flexible layer of silica gel, and lower layer is composite conductive layers, and the electrode slice after cutting includes circular electrode and connection handle;Electrode base includes:The fixing nut of the outer fixed card buckle of electrode slice, electrode cable, brain electricity cap fixed pedestal, electrode slice outer fixed card buckle, electrode cable fixing buckle;Wherein, it is buckled outside electrode slice and silica gel flexible electrical pole piece is fixed on electrode base, be fixed by outer fixed card buckle fixing nut.Electrode cable is closely pressed with flexible silicon gel electrode piece by the high spot for buckling inner wall outside electrode slice, and is fixed on brain electricity cap fixed pedestal by fixed card buckle fixing nut.The present invention has good contact, and convenient, comfortable to wear, impedance is low between electrode-skin, and electric conductivity is excellent, can collect high quality EEG signals.

Description

一种柔性接触脑电电极及其制备方法A kind of flexible contact EEG electrode and preparation method thereof

技术领域technical field

本发明属于电生理信号检测技术领域,具体涉及一种脑电电极及其制备方法。The invention belongs to the technical field of electrophysiological signal detection, and in particular relates to an electroencephalogram electrode and a preparation method thereof.

背景技术Background technique

脑电波(Electroencephalogram, EEG)信号是由大脑皮层或头皮表面神经元细胞体生理活动产生的电位信息的综合,包含有大脑丰富的节律信息[1],可广泛应用于脑疾病诊断,康复,脑机接口(BCI),疲劳检测等领域。它被认为是检测癫痫发作,心理性非癫痫发作,偏头痛,脑病等疾病的主要方法[2],同时也是睡眠疾病诊断的重要依据。然而脑电信号幅度一般小于100μV[3],因此脑电信号的捕获对脑电电极本身以及后级调理电路提出了很高的要求。其中,后级调理电路技术已经趋于成熟。相比而言,由于电极复杂的电学特性、以及生物电信号采集的特殊要求,脑电电极的研究方兴未艾。Electroencephalogram (Electroencephalogram, EEG) signal is a synthesis of potential information generated by the physiological activities of neuron cells on the surface of the cerebral cortex or scalp. machine interface (BCI), fatigue detection and other fields. It is considered to be the main method for detecting epileptic seizures, psychogenic non-epileptic seizures, migraine, encephalopathy and other diseases [2], and it is also an important basis for the diagnosis of sleep disorders. However, the amplitude of the EEG signal is generally less than 100 μV [3], so the capture of the EEG signal puts forward very high requirements on the EEG electrode itself and the subsequent conditioning circuit. Among them, the post-stage conditioning circuit technology has become mature. In contrast, due to the complex electrical characteristics of electrodes and the special requirements for bioelectrical signal acquisition, research on EEG electrodes is in the ascendant.

现有技术中,脑电电极可以分为湿式电极和干式电极两大类。湿式电极指的是需要配合导电膏使用的电极。通过前期的皮肤准备以及在采集位置涂抹导电膏操作,使得在电极与人体皮肤表面形成一个金属-电解液界面,从而降低皮肤的超高电阻抗获得高信噪比的信号。现有的湿式电极以金杯电极(Gold Cup Electrode)[4]和Ag/AgCl电极[5]为代表。金杯电极是在纯银电极的基础上电镀金金属制备而成,克服了纯银电极长时间使用的氧化问题。使用时,需要使用导电膏将金杯电极和皮肤进行连接,等待充分接触并且信号稳定之后进行信号的采集。其作为EEG信号采集的标准电极,具有导电性能优良、信号稳定、信号信噪比高等优点。但是导电膏的涂覆需要在医护人员的帮助下使用大量的时间完成,并且长时间的采集将会导致被试者的不适,严重时将会导致过敏红肿反应。此外,实验后的清洗也非常麻烦。对于Ag/AgCl电极,由于其制备方便、价格便宜,并且具有电信号基线稳定、抗干扰能力强等电子学特点,因而被业界广泛使用。但是由于电极中的导电凝胶存在脱水干燥的现象,因而在长时间使用的时候其电特性会发生变化,在高精度的实验中将引入较大的噪声和误差。In the prior art, EEG electrodes can be divided into two types: wet electrodes and dry electrodes. Wet electrodes refer to electrodes that need to be used with conductive paste. Through the previous skin preparation and the application of conductive paste at the collection site, a metal-electrolyte interface is formed between the electrode and the surface of the human skin, thereby reducing the ultra-high electrical impedance of the skin and obtaining a signal with a high signal-to-noise ratio. The existing wet electrodes are represented by Gold Cup Electrode [4] and Ag/AgCl electrode [5]. The gold cup electrode is prepared by electroplating gold metal on the basis of pure silver electrodes, which overcomes the oxidation problem of pure silver electrodes after long-term use. When in use, it is necessary to use conductive paste to connect the gold cup electrode and the skin, wait for sufficient contact and the signal is stable before collecting the signal. As a standard electrode for EEG signal acquisition, it has the advantages of excellent electrical conductivity, stable signal, and high signal-to-noise ratio. However, the application of conductive paste requires a lot of time with the help of medical staff, and long-term collection will cause discomfort to the subjects, and in severe cases, it will cause allergic redness and swelling reactions. In addition, cleaning after the experiment is also very troublesome. As for the Ag/AgCl electrode, it is widely used in the industry because of its convenient preparation, low price, stable electrical signal baseline, strong anti-interference ability and other electronic characteristics. However, due to the phenomenon of dehydration and drying of the conductive gel in the electrode, its electrical characteristics will change when it is used for a long time, and large noise and errors will be introduced in high-precision experiments.

为了解决湿式电极存在的问题,各种研究都致力于研发不需要使用导电膏、导电凝胶的干式电极。干式电极由于不需要皮肤准备以及涂抹导电膏等操作,其非常适合应用于未来健康监护、康复、疾病诊疗以及脑机接口BCI等领域。微针电极[6]是目前脑电采集技术中最普遍采用的干电极。微针电极是一种使用微针技术设计研发的电极,其通过微细制造方法在硅材料、金属、聚合物和玻璃等材料表面制造形成的阵列式微针结构,直接刺穿角质层来减小其超高电阻抗对信号采集的影响。其使用较为方便可靠,具有较小的阻抗,较小的电化学特性,更利于长期测量使用。但是缺点在于使用时要避免伤到真皮层、避免对神经和血管的伤害。与此同时,其他的织物电极虽然在穿戴式心电、肌电信号采集系统中有着良好的应用,但是在应用于脑电采集时,由于头发带来的接触不良以及皮肤的阻抗效应使接触阻抗进一步增大,使得EEG信号的采集变得更加困难。In order to solve the problems of wet electrodes, various researches are devoted to the development of dry electrodes that do not require the use of conductive paste and conductive gel. Since dry electrodes do not require operations such as skin preparation and application of conductive paste, they are very suitable for future health monitoring, rehabilitation, disease diagnosis and treatment, and brain-computer interface BCI and other fields. Microneedle electrodes [6] are the most commonly used dry electrodes in EEG acquisition technology. The microneedle electrode is an electrode designed and developed using microneedle technology. It manufactures an array of microneedle structures on the surface of materials such as silicon, metal, polymer, and glass through microfabrication methods, and directly penetrates the stratum corneum to reduce its Effect of ultra-high electrical impedance on signal acquisition. It is more convenient and reliable to use, has smaller impedance and smaller electrochemical characteristics, and is more conducive to long-term measurement. But the disadvantage is that it should avoid damage to the dermis and nerves and blood vessels when using it. At the same time, although other fabric electrodes have a good application in wearable ECG and EMG signal acquisition systems, when they are applied to EEG acquisition, the contact impedance due to the poor contact caused by the hair and the impedance effect of the skin Further increase makes the acquisition of EEG signals more difficult.

为了克服传统湿式电极操作复杂、难以长时间可穿戴式采集信号,以及克服干式电极信号质量差等缺点,本发明提出了一种基于硅胶基底的柔性干电极。该电极与头皮结合舒适紧密,同时由于高导电材料的使用,使得在不使用导电膏、导电凝胶的前提下获得高质量的原始信号成为可能。经过电极电学性能的测试论证,表明该电极具有佩戴舒适、操作简便、灵敏精度高等优点,适用于健康监护、可穿戴式脑电信号采集等领域。In order to overcome the shortcomings of traditional wet electrodes such as complex operation, difficulty in long-term wearable signal acquisition, and poor signal quality of dry electrodes, this invention proposes a flexible dry electrode based on a silica gel substrate. The electrode is comfortably and tightly combined with the scalp. At the same time, due to the use of highly conductive materials, it is possible to obtain high-quality original signals without using conductive paste or conductive gel. After the test and demonstration of the electrical performance of the electrode, it is shown that the electrode has the advantages of comfortable wearing, easy operation, high sensitivity and precision, and is suitable for health monitoring, wearable EEG signal acquisition and other fields.

参考文献references

[1] 韩丰谈,朱险峰.医学影像设备安装与维修学[M].北京:人民卫生出版社,2008:162-172.[1] Han Fengtan, Zhu Xianfeng. Medical imaging equipment installation and maintenance [M]. Beijing: People's Health Publishing House, 2008: 162-172.

[2] Acharya, D., Rani, A., & Agarwal, S. (2015, September). EEG dataacquisition circuit system Based on ADS1299EEG FE. In Reliability, InfocomTechnologies and Optimization (ICRITO)(Trends and Future Directions), 20154th International Conference on (pp. 1-5). IEEE.[2] Acharya, D., Rani, A., & Agarwal, S. (2015, September). EEG dataacquisition circuit system Based on ADS1299EEG FE. In Reliability, InfocomTechnologies and Optimization (ICRITO) (Trends and Future Directions), 20154th International Conference on (pp. 1-5). IEEE.

[3] Oohashi, T., Kawai, N., Honda, M., Nakamura, S., Morimoto, M.,Nishina, E., & Maekawa, T. (2002). Electroencephalographic measurement ofpossession trance in the field. Clinical Neurophysiology, 113(3), 435-445.[3] Oohashi, T., Kawai, N., Honda, M., Nakamura, S., Morimoto, M.,Nishina, E., & Maekawa, T. (2002). Electroencephalographic measurement of possession trance in the field. Clinical Neurophysiology, 113(3), 435-445.

[4] Tallgren, P., Vanhatalo, S., Kaila, K., & Voipio, J. (2005).Evaluation of commercially available electrodes and gels for recording ofslow EEG potentials. Clinical Neurophysiology, 116(4), 799-806.[4] Tallgren, P., Vanhatalo, S., Kaila, K., & Voipio, J. (2005).Evaluation of commercially available electrodes and gels for recording ofslow EEG potentials. Clinical Neurophysiology, 116(4), 799- 806.

[5] Verma, N., Shoeb, A., Bohorquez, J., Dawson, J., Guttag, J., &Chandrakasan, A. P. (2010). A micro-power EEG acquisition SoC with integratedfeature extraction processor for a chronic seizure detection system. IEEEJournal of Solid-State Circuits, 45(4), 804-816.[5] Verma, N., Shoeb, A., Bohorquez, J., Dawson, J., Guttag, J., &Chandrakasan, A. P. (2010). A micro-power EEG acquisition SoC with integratedfeature extraction processor for a chronic seizure detection system. IEEE Journal of Solid-State Circuits, 45(4), 804-816.

[6]刘冉,王晓浩,&周兆英.(2004).MEMS 微针阵列及其在生物医学上的应用.生物医学工程学杂志,21(3),482-485.。[6] Liu Ran, Wang Xiaohao, & Zhou Zhaoying. (2004). MEMS microneedle array and its application in biomedicine. Journal of Biomedical Engineering, 21 (3), 482-485.

发明内容Contents of the invention

本发明的目的在于提供一种导电性能优良,抗干扰能力强,使用方便,佩戴舒适,生产成本低的新型柔性接触脑电电极及其制备方法。The purpose of the present invention is to provide a novel flexible contact EEG electrode with excellent electrical conductivity, strong anti-interference ability, convenient use, comfortable wearing, and low production cost and its preparation method.

本发明提供的柔性接触脑电电极,由柔性硅胶电极片D和电极基座两部分构成;其结构参见图2、图4所示。其中,所述柔性硅胶电极片为双层结构,上层为柔性硅胶层,下层为复合导电层,从功能上,柔性硅胶电极片D由一圆形电极和与圆形电极连接的连接柄构成;所述电极基座包括:电极导线A,固定螺母B,电极导线固定扣C,脑电帽固定基座E,电极片外固定卡扣F;其中:The flexible contact EEG electrode provided by the present invention is composed of two parts: a flexible silicone electrode piece D and an electrode base; its structure is shown in Fig. 2 and Fig. 4 . Wherein, the flexible silicone electrode sheet has a double-layer structure, the upper layer is a flexible silicone layer, and the lower layer is a composite conductive layer. Functionally, the flexible silicone electrode sheet D is composed of a circular electrode and a connecting handle connected to the circular electrode; The electrode base includes: electrode wire A, fixing nut B, electrode wire fixing buckle C, EEG cap fixing base E, electrode sheet external fixing buckle F; wherein:

所述脑电帽固定基座E,用于安置柔性硅胶电极片D以及电极导线A;脑电帽固定基座E外形基本为柱形,其上设有用于放置柔性硅胶电极片D连接柄与电极导线A前端的安置凹槽;位于安置凹槽上部,设有固定电极导线A用的导线固定凹槽 ;脑电帽固定基座E下缘为外凸的球形曲面;柔性硅胶电极片D的圆形电极部分无导电材料一面紧贴于脑电帽固定基座E下部球形曲面;柔性硅胶电极片D的连接柄另一端的涂有导电层的一面与电极导线A的一端接触,固定于电帽固定基座E上的安置凹槽内;The EEG cap fixing base E is used to place the flexible silicone electrode sheet D and the electrode wire A; the shape of the EEG cap fixing base E is basically cylindrical, and it is provided with a connecting handle and a connecting handle for placing the flexible silicone electrode sheet D on it. The placement groove at the front end of the electrode wire A; located on the upper part of the placement groove, there is a wire fixing groove for fixing the electrode wire A; the lower edge of the EEG cap fixing base E is a convex spherical surface; the flexible silicone electrode piece D One side of the circular electrode part without conductive material is closely attached to the spherical surface of the lower part of the EEG cap fixing base E; the other end of the connecting handle of the flexible silicone electrode sheet D, which is coated with a conductive layer, is in contact with one end of the electrode wire A, and is fixed on the electrode wire A. In the placement groove on the cap fixing base E;

所述固定螺母B用于固定电极片外固定卡扣F;The fixing nut B is used to fix the outer fixing buckle F of the electrode sheet;

所述电极导线A,用于传递柔性硅胶电极片D上所采集到的电信号,并连接外部电路板;电极导线A的一部分导放置在导线固定凹槽内,由电极导线固定扣C固定于脑电帽固定基座E上;The electrode wire A is used to transmit the electrical signal collected on the flexible silicone electrode sheet D, and connect to the external circuit board; a part of the electrode wire A is placed in the wire fixing groove, and is fixed on the electrode wire by the electrode wire fixing buckle C. The EEG cap is fixed on the base E;

所述电极导线固定扣C用于将电极导线A固定于脑电帽固定基座E上;The electrode wire fixing buckle C is used to fix the electrode wire A on the EEG cap fixing base E;

所述电极片外固定卡扣F,其内部为空腔,该空腔形状与脑电帽固定基座E外形匹配,空腔上口与固定螺母B的下口匹配,内侧设有隆起G,其下缘为通孔,并且电极片外固定卡扣F设有与固定螺母B内螺纹匹配的外螺纹;脑电帽固定基座E位于电极片外固定卡扣F的空腔内;电极片外固定卡扣F内侧的隆起G将位于脑电帽固定基座E上安置凹槽内的性硅胶电极片D连接柄与电极导线A前端紧密压合、固定;电极片外固定卡扣F将柔性硅胶电极片D固定于脑电帽固定基座E底部,并且,脑电帽固定基座E底部的球形面将柔性硅胶电极片D的圆形电极的一部分推出电极片外固定卡扣F下缘孔外,从而使得电极片表面可以充分接触到头皮。The outer fixing buckle F of the electrode sheet is a cavity, the shape of the cavity matches the shape of the EEG cap fixing base E, the upper opening of the cavity matches the lower opening of the fixing nut B, and the inner side is provided with a bulge G, Its lower edge is a through hole, and the external fixing buckle F of the electrode sheet is provided with an external thread matching the internal thread of the fixing nut B; the EEG cap fixing base E is located in the cavity of the external fixing buckle F of the electrode piece; the electrode piece The bulge G on the inner side of the external fixing buckle F will press and fix the silicone electrode sheet D in the groove on the EEG cap fixing base E and the front end of the electrode wire A tightly; the electrode sheet external fixing buckle F will The flexible silicone electrode sheet D is fixed on the bottom of the EEG cap fixing base E, and the spherical surface at the bottom of the EEG cap fixing base E pushes a part of the round electrode of the flexible silicone electrode sheet D out of the electrode sheet outside the fixing buckle F Outside the edge hole, so that the surface of the electrode pad can fully contact the scalp.

固定螺母B与电极片外固定卡扣F通过螺纹结合后将电帽固定基座E及柔性硅胶电极片D和电极导线A接头固定在其内部。The fixing nut B and the electrode sheet external fixing buckle F are threadedly combined to fix the electric cap fixing base E, the flexible silicone electrode sheet D and the electrode lead A joint inside it.

本发明中,所述脑电帽固定基座E上安置凹槽,其尺寸为:长4mm,宽5mm,深1mm。In the present invention, a groove is arranged on the fixing base E of the EEG cap, and its size is: length 4mm, width 5mm, depth 1mm.

本发明中,所述电极导线固定扣C内测的隆起G其宽为5mm,该隆起顶点距离电极片外固定卡扣F的内表面高度为0.5mm。In the present invention, the bulge G on the inside of the electrode wire fixing buckle C has a width of 5 mm, and the height of the bulge apex from the inner surface of the electrode sheet outer fixing buckle F is 0.5 mm.

本发明中,柔性硅胶电极片圆形部分直径略大于电极片外固定卡扣F下底面内孔径。电极片外固定卡扣F下底面通孔内径尺寸为12-14mm.。In the present invention, the diameter of the circular part of the flexible silicone electrode sheet is slightly larger than the inner aperture of the lower bottom surface of the outer fixing buckle F of the electrode sheet. The inner diameter of the through hole on the lower bottom surface of the electrode piece external fixing buckle F is 12-14mm.

本发明中,柔性硅胶电极片D的圆形电极部分的顶点凸出于电极片外固定卡扣F下缘孔外1.5mm-2mm,以确保电极片表面充分接触到头皮。In the present invention, the vertex of the circular electrode part of the flexible silicone electrode sheet D protrudes 1.5mm-2mm outside the lower edge hole of the outer fixing buckle F of the electrode sheet to ensure that the surface of the electrode sheet fully contacts the scalp.

使用时,所述电极紧贴头皮,电极柔软,信号良好,保证了长期反复佩戴的属性。When in use, the electrode is close to the scalp, the electrode is soft, and the signal is good, which ensures the property of long-term repeated wearing.

本发明提供的柔性接触脑电电极的制备方法,具体步骤为:The preparation method of the flexible contact EEG electrode provided by the invention, the specific steps are:

(一)柔性硅胶电极片制备:(1) Preparation of flexible silicone electrode sheet:

(1)将金属纳米线分散液滴涂在光滑衬底表面,在60-100℃下加热,干燥,形成三维导电网络薄膜;这里,金属纳米线可以为银纳米线、铜纳米线、金纳米线等,金属纳米线分散液的浓度可以为1-10 wt%;所述衬底可以为玻璃、硅片、陶瓷等;(1) Apply the metal nanowire dispersion droplet on the surface of a smooth substrate, heat at 60-100°C, and dry to form a three-dimensional conductive network film; here, the metal nanowires can be silver nanowires, copper nanowires, gold nanowires, etc. wire, etc., the concentration of the metal nanowire dispersion can be 1-10 wt%; the substrate can be glass, silicon wafer, ceramics, etc.;

(2)将硅胶溶液浇筑到步骤(1)制备得到的三维导电网络薄膜表面,静置0.5-5h,待溶液完全渗透到三维导电网络空隙中,在60-100℃下加热2-12h,待硅胶完全固化后从衬底表面小心剥离,得柔性硅胶电极材料;这里,所述硅胶溶液可以选自聚二甲基硅氧烷(PDMS)、苯乙烯-丁二烯-苯乙烯嵌段共聚物(SBS)或聚氨酯(PU)等;(2) Pour the silica gel solution onto the surface of the three-dimensional conductive network film prepared in step (1), and let it stand for 0.5-5 hours. After the solution completely penetrates into the voids of the three-dimensional conductive network, heat it at 60-100°C for 2-12 hours, and wait for After the silica gel is completely cured, it is carefully peeled off from the surface of the substrate to obtain a flexible silica gel electrode material; here, the silica gel solution can be selected from polydimethylsiloxane (PDMS), styrene-butadiene-styrene block copolymer (SBS) or polyurethane (PU), etc.;

(3)将制备得到的柔性硅胶电极材料切割成电极形状:包括圆形部分和连接柄;如图3所示;(3) Cut the prepared flexible silicone electrode material into an electrode shape: including a circular part and a connecting handle; as shown in Figure 3;

一般地,电极片圆形部分直径a为12mm-14mm。连接柄长度b为4mm,宽度c为5mm。其中,导电层厚度e为1-10 μm,硅胶层厚度d为100-500 μm。Generally, the diameter a of the circular part of the electrode sheet is 12mm-14mm. The length b of the connecting handle is 4mm, and the width c is 5mm. Wherein, the thickness e of the conductive layer is 1-10 μm, and the thickness d of the silica gel layer is 100-500 μm.

(二)干燥柔性脑电电极的组装:(2) Assembly of dry flexible EEG electrodes:

(1)将电极导线(B)从脑电帽固定基座E与固定螺母B之间的缝隙穿入;(1) Insert the electrode lead (B) through the gap between the EEG cap fixing base E and the fixing nut B;

(2)将电极导线A前段(长约4mm)部分安置在脑电帽固定基座E上的安置槽内;电极导线采用FPC;(2) Place the front part of the electrode lead A (about 4mm in length) in the placement groove on the EEG cap fixing base E; the electrode lead uses FPC;

(3)将电极导线固定扣C插入脑电帽固定基座E上的位于导线固定凹槽内内,将放置在凹槽内的电极导线A固定在脑电帽固定基座E上,并且将电极导线A前端(4mm长度)部分放入安置凹槽内;(3) Insert the electrode wire fixing buckle C into the wire fixing groove on the EEG cap fixing base E, fix the electrode wire A placed in the groove on the EEG cap fixing base E, and place Put the front end (4mm length) of the electrode lead A into the placement groove;

(4)将裁剪好的柔性硅胶电极片D的连接柄插入电极导线A与安置槽内壁之间的空隙中;(4) Insert the connection handle of the cut flexible silicone electrode sheet D into the gap between the electrode wire A and the inner wall of the placement groove;

(5)将电极片外固定卡扣F内壁上的隆起处(G)对齐于安置凹槽,将电极片外固定卡扣F套在脑电帽固定基座E外面,并确保柔性硅胶电极片D因脑电帽固定基座下部球形曲面挤压而高于电极片外固定卡扣F下地面1.5mm-2mm;(5) Align the bulge (G) on the inner wall of the external fixing buckle F of the electrode piece with the placement groove, put the outer fixing buckle F of the electrode piece on the outside of the fixing base E of the EEG cap, and ensure the flexible silicone electrode piece D is 1.5mm-2mm higher than the ground under the external fixing buckle F of the electrode sheet due to the extrusion of the spherical surface of the lower part of the EEG cap fixing base;

(6)旋转固定螺母B,将电极片外固定卡扣F固定。(6) Rotate the fixing nut B to fix the outer fixing buckle F of the electrode piece.

本发明的柔性脑电电极具有良好的接触,方便的佩戴方式,舒适的佩戴体验,良好的体表皮肤贴合度,并且电极-皮肤间阻抗低,导电性能优良,能够采集到高质量的脑电信号。另外,柔性硅胶电极片生成成本极低,可大大降低使用成本。本发明操作简便,制作周期短,易于大规模生产。The flexible EEG electrode of the present invention has good contact, convenient wearing mode, comfortable wearing experience, good body surface skin fit, low electrode-skin impedance, excellent electrical conductivity, and can collect high-quality brain data. electric signal. In addition, the production cost of the flexible silicone electrode sheet is extremely low, which can greatly reduce the cost of use. The invention has the advantages of simple and convenient operation, short production period and easy large-scale production.

本发明的特点Features of the invention

所述柔性接触脑电电极具有良好的接触柔性。The flexible contact EEG electrode has good contact flexibility.

所述硅胶柔性电极具有很好的柔韧性,可以在任意角度范围内任意弯折而不影响其导电性。The silicone flexible electrode has good flexibility and can be bent at any angle without affecting its conductivity.

所述电极基座为可拆卸结构设计,该设计保证了硅胶柔性电极片替换操作的简易性。The electrode base is designed as a detachable structure, which ensures the ease of replacement of the silicone flexible electrode sheet.

所述硅胶柔性电极片与导线通过固定在电极片外卡扣上的导电扣压合,无需任何焊接,黏胶并具备良好的导电性。The silicone flexible electrode sheet and the wire are pressed together by the conductive buckle fixed on the outer buckle of the electrode sheet, without any welding, glue and good conductivity.

所述电极基座与硅胶柔性电极片接触面上设置了硅胶基座,进一步保证了使用者头皮与硅胶柔性电极片的柔性接触。A silicone base is provided on the contact surface between the electrode base and the silicone flexible electrode sheet, which further ensures the flexible contact between the user's scalp and the silicone flexible electrode sheet.

所述柔性接触脑电电极所采型号具有良好导电性能,能够采集到高质量的脑电信号。The model of the flexible contact EEG electrode has good electrical conductivity and can collect high-quality EEG signals.

附图说明Description of drawings

图1.电极实物图。Figure 1. The physical picture of the electrode.

图2.新型柔性脑电电极内部结构示意图。Figure 2. Schematic diagram of the internal structure of the new flexible EEG electrode.

图3.柔性硅胶电极片尺寸。Figure 3. Flexible silicone electrode sheet dimensions.

图4.柔性电极安装步骤示意图。Figure 4. Schematic diagram of flexible electrode installation steps.

图5.柔性硅胶电极截面和导电层表面电镜照片。Figure 5. Electron micrographs of the cross-section of the flexible silicone electrode and the surface of the conductive layer.

图6.柔性脑电电极与Ag/AgCl电极、金杯电极在Fp1区域的皮肤-电极间阻抗对比。Figure 6. Skin-electrode impedance comparison of flexible EEG electrodes, Ag/AgCl electrodes, and gold cup electrodes in the Fp1 region.

图7.柔性脑电电极与Ag/AgCl电极、金杯电极在F3区域的皮肤-电极间阻抗对比。Figure 7. Skin-electrode impedance comparison of flexible EEG electrodes, Ag/AgCl electrodes, and gold cup electrodes in the F3 region.

图8.柔性脑电电极与Ag/AgCl电极、金杯电极在Fp1区域采集到的脑电信号对比。Figure 8. Comparison of EEG signals collected by flexible EEG electrodes, Ag/AgCl electrodes, and gold cup electrodes in the Fp1 area.

图9.柔性脑电电极与Ag/AgCl电极、柔性硅胶电机、金杯电极在Fp1区域采集到的脑电信号频域对比。Figure 9. Frequency-domain comparison of EEG signals collected by flexible EEG electrodes, Ag/AgCl electrodes, flexible silicone motors, and gold cup electrodes in the Fp1 region.

图10.柔性脑电电极与金杯电极在F3区域采集到的脑电信号对比。Figure 10. Comparison of the EEG signals collected by the flexible EEG electrode and the Jinbei electrode in the F3 area.

图11.柔性脑电电极与金杯电极在F3区域采集到的脑电信号频域对比。Figure 11. Frequency-domain comparison of EEG signals collected by flexible EEG electrodes and Jinbei electrodes in the F3 area.

图中标号:A为电极导线,B为卡扣固定螺母,C为固定扣,D为柔性硅胶电极片,E为脑电帽固定基座,F为电极片外固定卡扣,G为内侧隆起。Labels in the figure: A is the electrode wire, B is the buckle fixing nut, C is the fixing buckle, D is the flexible silicone electrode piece, E is the fixing base of the EEG cap, F is the outer fixing buckle of the electrode piece, G is the inner bulge .

具体实施方式Detailed ways

按前述步骤制备新型柔性脑电电极:Prepare new flexible EEG electrodes according to the above steps:

(一)柔性硅胶电极片的制备:(1) Preparation of flexible silicone electrode sheet:

(1)将2 ml浓度为5 wt%的银纳米线(Ag NWs)分散液滴涂在5cm×5cm玻璃衬底表面,60℃加热干燥10min得到三维银纳米线导电网络薄膜;(1) 2 ml of silver nanowire (Ag NWs) dispersion with a concentration of 5 wt% was drop-coated on the surface of a 5 cm × 5 cm glass substrate, and heated and dried at 60 °C for 10 min to obtain a three-dimensional silver nanowire conductive network film;

(2)将1mlPDMS溶液浇筑到步骤(1)制备得到的银纳米线导电网络薄膜表面,静置1h,然后60℃加热固化5h,待PDMS完全固化后小心从玻璃衬底表面剥离得到柔性硅胶电极,其具体结构见附图2,纯PDMS硅胶层作为柔性衬底,厚度为100μm,Ag NWs/PDMS复合层作为导电层,厚度为10μm。需要说明的是,Ag NWs三维导电网络是嵌在PDMS表面内的,而不是只是简单的覆盖在其表面,因此在满足导电性的情况下,同时具有很好的附着力,在弯曲、扭曲、甚至拉伸的情况下不会发生脱落,完全满足脑电电极的应用需求。(2) Pour 1ml of PDMS solution onto the surface of the silver nanowire conductive network film prepared in step (1), let it stand for 1h, then heat and cure at 60°C for 5h, and carefully peel off the PDMS from the surface of the glass substrate after the PDMS is completely cured to obtain a flexible silicone electrode , its specific structure is shown in Figure 2, the pure PDMS silica gel layer is used as a flexible substrate with a thickness of 100 μm, and the Ag NWs/PDMS composite layer is used as a conductive layer with a thickness of 10 μm. It should be noted that the three-dimensional conductive network of Ag NWs is embedded in the surface of PDMS, rather than simply covering its surface, so it has good adhesion under the condition of satisfying the conductivity, and can withstand bending, twisting, Even in the case of stretching, it will not fall off, which fully meets the application requirements of EEG electrodes.

将新型柔性硅胶脑电电极的按图4进行安装并测试。首先将FPC电极导线A从脑电帽固定基座E与电极片外固定卡扣固定螺母B之间的缝隙穿入;然后将FPC电极导线A前段长约4mm部分安置在脑电帽固定基座E上的安置槽内;紧接着将电极导线固定卡扣F插入在脑电帽固定基座上位于安置槽上方的卡槽内;随后再将按照图3裁剪好的柔性硅胶电极片D的连接柄插入FPC电极导线A与安置槽内壁之间的空隙中;此外,将电极片外固定卡扣F内壁上的隆起处对齐于安置槽后,将电极片外固定卡扣F套在脑电帽固定基座外面,并确保柔性硅胶电极因脑电帽固定基座下部球形面挤压而高于电极片外固定卡扣F下缘约为1.5mm;最后将旋转电极片外固定卡扣固定螺母B将电极片外固定卡扣F固定。Install and test the new flexible silicone EEG electrodes according to Figure 4. First, insert the FPC electrode wire A through the gap between the EEG cap fixing base E and the electrode sheet external fixing buckle fixing nut B; then place the front part of the FPC electrode wire A about 4mm long on the EEG cap fixing base In the placement slot on E; then insert the electrode wire fixing buckle F into the card slot above the placement slot on the EEG cap fixing base; then connect the flexible silicone electrode sheet D cut according to Figure 3 Insert the handle into the gap between the FPC electrode wire A and the inner wall of the placement groove; in addition, after aligning the bulge on the inner wall of the outer fixing buckle F of the electrode piece with the placement groove, put the outer fixing buckle F of the electrode piece on the EEG cap Fix the outer surface of the base, and ensure that the flexible silicone electrode is about 1.5mm higher than the lower edge of the outer fixing buckle F of the electrode piece due to the extrusion of the spherical surface of the lower part of the EEG cap fixing base; finally, fix the fixing nut of the outer fixing buckle of the rotating electrode piece B Fix the external fixing buckle F of the electrode piece.

目前,在临床上广泛使用的脑电电极是金杯电极或者Ag/AgCl电极,往往在电极与皮肤接触部分附有导电凝胶提升贴合程度和导电性能、降低皮肤-电极间阻抗。然而,随着使用时间的增加,导电凝胶趋于硬化、有关性能显著下降。At present, the EEG electrodes widely used clinically are gold cup electrodes or Ag/AgCl electrodes, often with conductive gel attached to the contact part of the electrode and the skin to improve the fit and conductivity, and reduce the skin-electrode impedance. However, as the use time increases, the conductive gel tends to harden, and the related performance decreases significantly.

本发明提出的柔性脑电电极不需要导电凝胶,材料自身的力学性能使其能长期保持与皮肤的良好接触。电化学工作站测试结果显示,所提出的电极的皮肤-电极间阻抗在0.1 Hz-100k Hz范围内与金杯电极和Ag/AgCl电极可比,而几乎所有生理信号(如脑电、心电、肌电等)的频率都分布在0.1 Hz 到 1k Hz的 范围内。其不需要导电凝胶的特点使其在可穿戴设备的应用场景中相较于Ag/AgCl电极具有明显优势,跟金杯电极相比,采集到的质量不分上下,且适宜长期监护。图6和图7分别给出了本专利所提出的电极与金杯电极、Ag/AgCl电极的皮肤-电极间阻抗在0.1 Hz-100k Hz范围内在Fp1(左额极,无头发附着)和F3(左额,有头发附着)位置的对比。在0.1Hz到200KHz频段内,专利提出的柔性硅胶电极具有最小的皮肤电极界面阻抗,在直流频段附近大约为金杯电极的一半(15K欧姆左右),同时阻抗分布与EEG标准金杯电极相似。较小的皮肤电极界面阻抗使得等效信号源内阻较小,从而减弱由于信号源内阻较大带来的信号畸变问题。三种电极中Ag/AgCl电极具有最大的阻抗,对应在实际应用中很难使用Ag/AgCl电极进行EEG信号的采集。The flexible EEG electrode proposed by the present invention does not require conductive gel, and the mechanical properties of the material itself enable it to maintain good contact with the skin for a long time. The results of the electrochemical workstation test show that the skin-electrode impedance of the proposed electrode is comparable to that of the gold cup electrode and Ag/AgCl electrode in the range of 0.1 Hz-100k Hz, while almost all physiological signals (such as EEG, ECG, EMG) etc.) are distributed in the range of 0.1 Hz to 1k Hz. It does not require conductive gel, so it has obvious advantages over Ag/AgCl electrodes in the application scenarios of wearable devices. Compared with Jinbei electrodes, the quality of the collected data is comparable, and it is suitable for long-term monitoring. Figure 6 and Figure 7 respectively show the skin-electrode impedance between the electrode proposed in this patent and the gold cup electrode and Ag/AgCl electrode in the range of 0.1 Hz-100k Hz at Fp1 (left frontal pole, no hair attached) and F3 ( The contrast of the position of the left forehead, with hair attached). In the 0.1Hz to 200KHz frequency band, the flexible silicone electrode proposed by the patent has the smallest skin electrode interface impedance, which is about half of the gold cup electrode (about 15K ohms) near the DC frequency band, and the impedance distribution is similar to the EEG standard gold cup electrode. The smaller skin electrode interface impedance makes the internal resistance of the equivalent signal source smaller, thereby reducing the signal distortion problem caused by the large internal resistance of the signal source. Among the three electrodes, the Ag/AgCl electrode has the largest impedance, which means that it is difficult to use the Ag/AgCl electrode to collect EEG signals in practical applications.

此外,对于电极而言,除了电学性能表现要优良之外,能够采集到有效的信号才是最终的目的。因此使用医疗级商用多导睡眠监护仪PSG(Compumedics Grael)设备进行信号采集验证。实验条件如下:为了保证严格的变量控制,受试者要求在实验前进行清洗保证试验不受汗水、油渍等的干扰,并且试验在一个小时内结束,假定在这段时间受试者身体状态保持不变(皮肤接触以及阻抗状态不会随时间推移发生大的变化导致试验失败),采样频率为256Hz。在Fp1区域利用三种电极进行对比测试。在F3区域,由于头发的干扰,Ag/AgCl电极采集到的信号质量较差,故在F3区域只进行了新型柔性脑电电极与金杯电极的对比测试。本实验对采集得到的原始信号进行时域以及频域分析,根据其特征论证电极设计的可行性。图8和图9分别给出了新型柔性脑电电极与Ag/AgCl电极、金杯电极在Fp1区域采集到的脑电信号以及频域分析对比图。图10和图11新型柔性脑电电极与金杯电极在F3区域采集到的脑电信号以及频域分析对比图。从时域来看,二者具有相同的波形,表明二者信号采集的有效性。从频域来看,二者采集信号的频谱结构完全一致,再一次论证了电极设计的合理性。In addition, for electrodes, in addition to excellent electrical performance, the ultimate goal is to be able to collect effective signals. Therefore, a medical grade commercial polysomnography PSG (Compumedics Grael) device was used for signal acquisition verification. The experimental conditions are as follows: In order to ensure strict variable control, the subjects are required to wash before the experiment to ensure that the test is not disturbed by sweat, oil stains, etc., and the test is over within one hour. Constant (skin contact and impedance state will not change greatly over time to cause the test to fail), the sampling frequency is 256Hz. In the Fp1 area, three kinds of electrodes were used for comparative testing. In the F3 area, due to the interference of the hair, the quality of the signal collected by the Ag/AgCl electrode was poor, so in the F3 area only the comparison test between the new flexible EEG electrode and the Jinbei electrode was carried out. In this experiment, time domain and frequency domain analysis are performed on the collected original signal, and the feasibility of electrode design is demonstrated according to its characteristics. Figure 8 and Figure 9 respectively show the comparison of the EEG signals collected by the new flexible EEG electrode, the Ag/AgCl electrode, and the Jinbei electrode in the Fp1 area and the frequency domain analysis. Figure 10 and Figure 11 compare the EEG signals collected by the new flexible EEG electrode and the Jinbei electrode in the F3 area and the frequency domain analysis. From the perspective of time domain, the two have the same waveform, indicating the validity of the signal acquisition of the two. From the perspective of the frequency domain, the spectrum structures of the two collected signals are completely consistent, which once again demonstrates the rationality of the electrode design.

Claims (9)

1. a kind of flexible contact electrode for encephalograms, which is characterized in that by flexible silicon gel electrode piece(D)With electrode base two parts structure At;The flexible silicon gel electrode piece is double-layer structure, and upper layer is flexible layer of silica gel, and lower layer is composite conductive layers, functionally, soft Property silica gel electrode slice(D)The connection handle being connect by a circular electrode and with circular electrode is constituted;The electrode base includes:Electrode Conducting wire(A), fixing nut(B), electrode cable fixing buckle(C), brain electricity cap fixed pedestal(E), the outer fixed card buckle of electrode slice(F); Wherein:
The brain electricity cap fixed pedestal(E), for disposing flexible silicon gel electrode piece(D)And electrode cable(A);Brain electricity cap is fixed Pedestal(E)Shape is substantially cylindrical, which is provided with for placing flexible silicon gel electrode piece(D)Connection handle and electrode cable(A)Before The placement groove at end;Positioned at placement groove top, it is equipped with fixed electrode cable(A)Conducting wire fixed groove;Brain electricity cap is fixed Pedestal(E)Lower edge is the sphere curved surface of evagination;Flexible silicon gel electrode piece(D)Circular electrode portion be close on one side without conductive material In brain electricity cap fixed pedestal(E)Lower spherical curved surface;Flexible silicon gel electrode piece(D)The connection handle other end be coated with conductive layer On one side with electrode cable(A)End thereof contacts, be fixed on electric cap fixed pedestal(E)On placement groove in;
The electrode cable(A), for transmitting flexible silicon gel electrode piece(D)The upper collected electric signal of institute, and connect external electrical Road plate;Electrode cable(A)A part lead and be placed in conducting wire fixed groove, by electrode cable fixing buckle(C)It is fixed on brain electricity Cap fixed pedestal(E)On;
The electrode cable fixing buckle(C)For by electrode cable(A)It is fixed on brain electricity cap fixed pedestal(E)On;
The outer fixed card buckle of the electrode slice(F), internal is cavity, the cavity shape and brain electricity cap fixed pedestal(E)Shape Match, cavity is suitable for reading and fixing nut(B)Lower mouth matching, inside be equipped with protuberance(G), lower edge is through-hole, and outside electrode slice Fixed card buckle(F)It is equipped with and fixing nut(B)The matched external screw thread of internal thread;Brain electricity cap fixed pedestal(E)Outside electrode slice Fixed card buckle(F)Cavity in;The outer fixed card buckle of electrode slice(F)The protuberance of inside(G)Brain electricity cap fixed pedestal will be located at(E)On Dispose the property silica gel electrode slice in groove(D)Connection handle and electrode cable(A)Front end closely presses, is fixed;It is fixed outside electrode slice Buckle(F)By flexible silicon gel electrode piece(D)It is fixed on brain electricity cap fixed pedestal(E)Bottom, also, brain electricity cap fixed pedestal(E) The spherical of bottom is by flexible silicon gel electrode piece(D)The part of circular electrode release the outer fixed card buckle of electrode slice(F)Lower edge Outside hole, so that electrode slice surface can be adequately exposed to scalp;
Fixing nut(B)With fixed card buckle outside electrode slice(F)By electric cap fixed pedestal after engaged through the thread(E)And flexible silica gel Electrode slice(D)And electrode cable(A)Connector is fixed therein portion.
2. flexible contact electrode for encephalograms according to claim 1, which is characterized in that the brain electricity cap fixed pedestal(E)On Placement groove, size are:Long 4mm, wide 5mm, deep 1mm.
3. flexible contact electrode for encephalograms according to claim 1, which is characterized in that the electrode cable fixing buckle(C)It is interior The protuberance of survey(G), width 5mm, the outer fixed card buckle of the protuberance vertex distance electrode slice(F)Inner surface height be 0.5mm.
4. flexible contact electrode for encephalograms according to claim 1, which is characterized in that the flexible silicon gel electrode piece rounded portions Diameter is divided to be more than the outer fixed card buckle of electrode slice(F)Bottom surface internal orifice dimension;The outer fixed card buckle of electrode slice(F)Bottom surface through-hole internal diameter ruler Very little is 12-14mm..
5. flexible contact electrode for encephalograms according to claim 1, which is characterized in that the flexible silicon gel electrode piece(D)'s The vertex of circular electrode portion protrudes from the outer fixed card buckle of electrode slice(F)The outer 1.5mm-2mm of lower marginal pore, to ensure electrode slice surface It is adequately exposed to scalp.
6. a kind of preparation method of flexible contact electrode for encephalograms as described according to one of claim 1-5, which is characterized in that tool Body step is:
(One)It is prepared by flexible silicon gel electrode piece:
(1)Metal nanometer line dispersant liquid drop is coated in smooth substrates surface, is heated at 60-100 DEG C, it is dry, it forms three-dimensional and leads Electric network film;
(2)Silica gel solution is poured into step(1)The three-dimensional conductive network thin-film surface being prepared stands 0.5-5h, waits for molten Liquid completely penetrates in three-dimensional conductive network gap, and 2-12h is heated at 60-100 DEG C, from substrate table after silica gel is fully cured Face is removed, and flexible silicon gel electrode material is obtained;
(3)The flexible silicon gel electrode material being prepared is cut into electrode shape:Including circular portion and connection handle;
(Two)The assembling of dry flexibility electrode for encephalograms:
(1)By electrode cable(A)From brain electricity cap fixed pedestal(E)With fixing nut(B)Between gap penetrate;
(2)By electrode cable(A)Fore-end is placed in brain electricity cap fixed pedestal(E)On resettlement groove in;
(3)By electrode cable fixing buckle(C)It is inserted into brain electricity cap fixed pedestal(E)On be located at conducting wire fixed groove in, will put Set the electrode cable in groove(A)It is fixed on brain electricity cap fixed pedestal(E)On, and by electrode cable(A)Fore-end is put Enter to dispose in groove;
(4)The flexible silicon gel electrode piece that will be cut(D)Connection handle be inserted into electrode cable(A)With the sky between resettlement groove inner wall In gap;
(5)By fixed card buckle outside electrode slice(F)Bump pad on inner wall(G)It is aligned in placement groove, by fixing card outside electrode slice Button(F)It is sleeved on brain electricity cap fixed pedestal(E)Outside, and ensure flexible silicon gel electrode piece(D)Because of brain electricity cap fixed pedestal lower ball Shape curved surface squeezes and is higher than the outer fixed card buckle of electrode slice(F)Lower ground 1.5mm-2mm;
(6)Rotary fixing screw is female(B), by fixed card buckle outside electrode slice(F)It is fixed.
7. preparation method according to claim 6, which is characterized in that step(1)In, the metal nanometer line is received for silver Rice noodles, copper nano-wire or nanowires of gold, a concentration of 1-10 wt% of metal nanometer line dispersion liquid.
8. preparation method according to claim 6, which is characterized in that step(2)In, the silica gel solution is selected from poly- two Methylsiloxane, Styrene-Butadiene-Styrene Block Copolymer or polyurethane.
9. preparation method according to claim 6, which is characterized in that step(3)In, electrode slice circular portion diameter a is 12mm-14mm;Connection handle length b is 4mm, and width c is 5mm;Wherein, conductive layer thickness e is 1-10 μm, and layer of silica gel thickness d is 100-500 μm。
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