CN108295105B

CN108295105B - New application of trifoliate acanthopanax extract

Info

Publication number: CN108295105B
Application number: CN201810311312.2A
Authority: CN
Inventors: 武文敬; 何燕; 梁立尹; 易如婷; 蔡浛; 张焜
Original assignee: Guangdong University of Technology
Current assignee: Guangdong University of Technology
Priority date: 2018-04-09
Filing date: 2018-04-09
Publication date: 2021-05-11
Anticipated expiration: 2038-04-09
Also published as: CN108295105A

Abstract

The invention relates to the technical field of medicines, in particular to application of an Acanthopanax trifoliatus extract in preparing a medicine for treating mosquito bites. Experiments prove that the acanthopanax trifoliatus extract for external use after mosquito bites can quickly relieve swelling and itching, has small irritation to skin, is wide in applicable population, and can be widely used for treating mosquito bites.

Description

New application of trifoliate acanthopanax extract

Technical Field

The invention relates to the technical field of medicines, in particular to a new application of an acanthus ilicifolius extract.

Background

The mosquito belongs to the family of the Insecta diptera, is a tiny winged insect with piercing-sucking mouthparts, about 3000 species are found in the world, and more than 300 species are found in China. Mosquitoes usually feed on the blood of the female, while the male sucks in the sap of the plant. The mosquito stabs skin through the mouth organ, saliva or venom invades skin, and the saliva or venom of the mosquito contains a plurality of antigen components, and the antigens can generate allergic reaction with antibodies after entering the skin of a human body to cause inflammation. Round or oval, large rice grains or red pimples, cold sores or edematous erythema of soybean size, accompanied by severe itching, especially at night, occur on exposed or directly contacted parts of the skin after being bitten by mosquitoes. In a word, the mosquito bites not only influence the sleep of people, but also bite the skin of people, so that people can feel painful and itchy, other diseases can be infected, and great harm is brought to the life, work and health of people.

At present, products for repelling mosquitoes and relieving itching of people mainly comprise cooling oil, toilet water, essential balm and the like, the products are difficult to rapidly relieve swelling and itching, contain a certain alcohol component, are not suitable for people with sensitive skin, and have high taste irritation. In addition, there are some hormone drugs of glycyrrhetinic acid, which are not suitable for children though having good therapeutic effect.

Disclosure of Invention

The invention aims to provide application of an acanthus ilicifolius extract. Experiments prove that after being bitten by mosquitoes, the acanthopanax trifoliatus extract is externally applied to the skin, can quickly reduce swelling and relieve itching, has small irritation to the skin and is suitable for wide crowds.

The invention provides application of an acanthopanax trifoliatus extract in preparing a medicine for treating mosquito bites.

The researches of the invention find that the trifoliate acanthopanax extract can quickly relieve swelling and itching after being bitten by mosquitoes, and the trifoliate acanthopanax extract can be prepared into a medicine for treating the bites by the mosquitoes.

In the application, the medicine comprises the acanthopanax trifoliatus extract, the diphenhydramine hydrochloride and pharmaceutically acceptable auxiliary materials.

In the application, the medicine also comprises one or more of menthol, camphor, wintergreen oil, menthol, amur cork tree bark extract, hydrolyzed pearl, honeysuckle flower extract, olive oil, turpentine oil, thyme oil, clove oil, cassia oil, cinnamon oil, angelica, patchouli, liquorice, cinnamon, dried orange peel, gardenia, ligusticum wallichii, dragon's blood and borneol.

In some embodiments provided herein, the medicament further comprises menthol and camphor.

Preferably, the pharmaceutically acceptable auxiliary materials are selected from one or more than two of artificial musk, artificial bezoar, agar, EDTA disodium, essence and the like.

Preferably, the medicament is in the form of a spray, liquid or paste.

In some embodiments provided herein, the ointment is a topical ointment, including ointments and plasters.

In some embodiments provided herein, the topical ointment comprises acanthus trifoliatus extract, diphenhydramine hydrochloride, menthol, camphor, starch, and essence.

Preferably, the preparation method of the acanthopanax trifoliatus extract comprises the following steps: the trifoliate acanthopanax extract is obtained by extracting and concentrating trifoliate acanthopanax through an organic solvent.

Wherein the organic solvent is one or more of ethanol, acetone, n-butanol, and ethyl acetate.

Preferably, the ethanol concentration is 20% to 100%, more preferably 70% to 95%.

Preferably, the concentration is a concentration under reduced pressure.

Preferably, the preparation method of the acanthopanax trifoliatus extract comprises the following steps:

cleaning trifoliate acanthopanax, and airing for later use;

adding 10-100 times of ethanol for extraction at the extraction temperature of-10-60 ℃, extracting for 1-4 times for 1-12 hours each time, filtering, combining filtrate, and concentrating under reduced pressure and vacuum to obtain the acanthopanax trifoliatus extract.

In some embodiments provided by the invention, the extraction temperature is-4 ℃ to 35 ℃, and the extraction is carried out for 2 to 3 times, 10 to 12 hours each time.

The invention provides a new application of acanthopanax trifoliatus extract. Researches show that the acanthopanax trifoliatus extract can quickly relieve swelling and itching after being bitten by mosquitoes, has small irritation to skin and is suitable for wide crowds. Further research shows that the external medicament prepared from the acanthopanax trifoliatus extract, the diphenhydramine hydrochloride, the menthol and the camphor has more remarkable effect of treating mosquito bites.

Detailed Description

The invention discloses a new application of acanthopanax trifoliatus extract, and a person skilled in the art can appropriately improve process parameters by taking the contents into account. It is expressly intended that all such similar substitutes and modifications which would be obvious to one skilled in the art are deemed to be included in the invention. While the methods and applications of this invention have been described in terms of preferred embodiments, it will be apparent to those of ordinary skill in the art that variations and modifications in the methods and applications described herein, as well as other suitable variations and combinations, may be made to implement and use the techniques of this invention without departing from the spirit and scope of the invention.

The description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

The invention is further illustrated by the following examples:

example 1 preparation of Acanthopanax trifoliatus extract

Cleaning trifoliate acanthopanax, and airing for later use;

adding 10 times of 70% ethanol for extraction, controlling the temperature at 0 ℃, extracting for 2 times, each time for 12 hours, filtering, combining filtrate, and concentrating under reduced pressure and vacuum to obtain the trifoliate acanthopanax extract.

Example 2 preparation of Acanthopanax trifoliatus extract

Cleaning trifoliate acanthopanax, and airing for later use;

adding 20 times of n-butanol to extract, controlling the temperature at 0 ℃, extracting for 2 times, each time for 12 hours, filtering, combining filtrate, and concentrating under reduced pressure and vacuum to obtain the trifoliate acanthopanax extract.

EXAMPLE 3 preparation of Acanthopanax trifoliatus extract

Cleaning trifoliate acanthopanax, and airing for later use;

adding 100 times of ethyl acetate for extraction, controlling the temperature at 20 ℃, extracting for 3 times, each time for 10 hours, filtering, combining filtrate, and concentrating under reduced pressure and vacuum to obtain the trifoliate acanthopanax extract.

Example 4 the ointment of the present invention for treating mosquito bites

The formula comprises the following components:

acanthopanax trifoliatus extract of example 1: 0.5 g;

diphenhydramine hydrochloride: 2.0 g;

menthol: 5.0 g;

camphor: 1.0 g;

mixing the above materials, adding adjuvants, and making into unguent by conventional method.

Example 5 the ointment of the present invention for treating mosquito bites

The formula comprises the following components:

acanthopanax trifoliatus extract of example 2: 2.0 g;

diphenhydramine hydrochloride: 3.0 g;

menthol: 4.0 g;

camphor: 2.0 g;

Embodiment 6 the ointment for treating mosquito bite of the invention

The formula comprises the following components:

acanthopanax trifoliatus extract of example 3: 2.0 g;

diphenhydramine hydrochloride: 3.0 g;

menthol: 4.0 g;

camphor: 2.0 g;

EXAMPLE 7 Observation of therapeutic Effect

Randomly selecting 50 volunteers, putting hands into a cage for 2 minutes, smearing the extract of the embodiments 1-3 and the ointment of the embodiments 4-6 on the bitten part, and observing the treatment condition of the bitten part.

The experimental results are as follows: after the ointment of the embodiment 1-6 of the invention is applied to an affected part, the affected part is applied once, and pain and itching can be relieved after 1-3 min; the preparation is applied at an interval of 5min for detumescence.

By observation, after the extract of examples 1 to 3 and the ointment of examples 4 to 6 of the present invention were applied, there was no allergic reaction and any discomfort at the affected part.

The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.

Claims

1. Application of Acanthopanax trifoliatus extract in preparing medicine for treating mosquito bite;

the medicine comprises a trifoliate acanthopanax extract, diphenhydramine hydrochloride and pharmaceutically acceptable auxiliary materials;

the preparation method of the acanthopanax trifoliatus extract comprises the following steps:

extracting and concentrating trifoliate acanthopanax by using an organic solvent to obtain a trifoliate acanthopanax extract;

wherein the organic solvent is one or more of ethanol, acetone, n-butanol and ethyl acetate;

the extraction temperature is-4 ℃ to 35 ℃, and the extraction is carried out for 2 to 3 times in total, and each time lasts for 10 to 12 hours.

2. The use of claim 1, wherein the medicament further comprises one or more of menthol, camphor.

3. The use of claim 1, wherein the pharmaceutically acceptable adjuvant is one or more selected from artificial musk, artificial bezoar, agar, disodium EDTA, starch and essence.

4. The use according to claim 1, wherein the medicament is in the form of a spray, liquid or paste.

5. Use according to claim 1, wherein the concentration is a concentration under reduced pressure.