CN108283627A - A method of preparing starch capsule by major ingredient of hair sweet potato starch - Google Patents
A method of preparing starch capsule by major ingredient of hair sweet potato starch Download PDFInfo
- Publication number
- CN108283627A CN108283627A CN201810320071.8A CN201810320071A CN108283627A CN 108283627 A CN108283627 A CN 108283627A CN 201810320071 A CN201810320071 A CN 201810320071A CN 108283627 A CN108283627 A CN 108283627A
- Authority
- CN
- China
- Prior art keywords
- starch
- parts
- hair
- capsule
- sweet potato
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B30/00—Preparation of starch, degraded or non-chemically modified starch, amylose, or amylopectin
- C08B30/02—Preparatory treatment, e.g. crushing of raw materials or steeping process
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B30/00—Preparation of starch, degraded or non-chemically modified starch, amylose, or amylopectin
- C08B30/04—Extraction or purification
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B30/00—Preparation of starch, degraded or non-chemically modified starch, amylose, or amylopectin
- C08B30/06—Drying; Forming
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B30/00—Preparation of starch, degraded or non-chemically modified starch, amylose, or amylopectin
- C08B30/12—Degraded, destructured or non-chemically modified starch, e.g. mechanically, enzymatically or by irradiation; Bleaching of starch
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Materials Engineering (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a kind of methods preparing starch capsule as major ingredient using hair sweet potato starch, include the following steps：(1) preparation of hair sweet potato starch；(2) preparation of porous-starch：Hair sweet potato starch, enzymolysis buffer solution are put into enzymatic vessel, 4h~5h is reacted, the pH value for adjusting reaction system is 7.5~8.5, forms suspension, after suspension is filtered with plate and frame filter, takes filter residue to carry out infra-red drying processing, obtains porous-starch；(3) preparation of capsule：Porous-starch, pure water, sodium alginate, emulsifier and collagen are put into reactor, 95 DEG C is warming up to the heating rate of 5 DEG C/min, stirs 2h~3h, until material gelatinization completely is transparent, it is cooled to room temperature, compression molding, it is dry, obtain starch capsule.Hair sweet potato starch capsule disintegration time prepared by the present invention is short.Water-retaining property is high, can replacing gelatin capsule completely, the market to widen starch capsule provides new research direction.
Description
【Technical field】
The present invention relates to starch field of capsules, more particularly to a kind of side preparing starch capsule using hair sweet potato starch as major ingredient
Method.
【Background technology】
Capsule has more than 160 years applicating history, can be used as the carrier of medicament in medicine, health products and functional food
There is very extensive application in industry.Currently, the primary raw material of production hard capsule is gelatin both at home and abroad.Gelatin is using dynamic
Animal protein colloid made of the skin of object, bone, tendon are made through techniques such as slagging-off, disinfection, boiling, dehydrations, but certainly due to gelatin
The generation of body defect and food and drug safety problem, the deficiency and security risk of gelatine capsule are by it has been found that main performance
：(1) protein molecule is easy to be crosslinked with drug ingedients such as recuding sugars compound and vitamin Cs in gelatin, both influences capsule
Disintegration again influence drug stability；(2) capsule water-retaining property is poor, and the long time stored toughness in dry environment reduces, and becomes
It is crisp, cause capsule intensity low, cracky；(3) wide-scale distribution due to rabid ox disease worldwide, North America, Latin American
Country is all forbidden to use this area as the production country that the hereditary area of rabid ox disease is also main gelatin in the world, many countries
Capsule for medicine.
In order to overcome defect existing for gelatine capsule, domestic and international Research Center in one's power business unit put into one after another a large amount of manpowers,
Material resources, financial resources research and develop non-gelatin capsules.Starch and its derivative are also obtained as one of the important source material for preparing capsule
The extensive research of domestic and foreign scholars.
Hair potato also known as multitude hole potato, sweet potato, chicken coop potato etc., are one kinds of Dioscorea, ripe to eat a mao potato energy invigorating the spleen to arrest diarrhea, beneficial lung
Nourshing kidney, removing toxic substances sore.Since ancient times, hair potato is liked by the general common people deeply.The Medical Nutritional value of hair potato is very high,
Stem tuber can promote the granulation of ulcer to grow, and have and receive aquatic flesh, make the effect of scabbing of sore face；Soup can be controlled by, which smashing, injures face
Rotten sore.Therefore, a kind of method preparing starch capsule as major ingredient using hair sweet potato starch of research has the market for widening starch capsule
There is profound significance.
【Invention content】
Present invention aims at a kind of method preparing starch capsule as major ingredient using hair sweet potato starch is provided, first it is being passed through dioxy
The hair sweet potato starch of high-efficiency low-toxicity is prepared under conditions of change carbon and nitrogen gas；Then porous-starch is precipitated at the low ph；
Finally starch capsule is prepared under conditions of slow heating.Hair sweet potato starch capsule disintegration time prepared by the present invention is short.Water-retaining property
Height, can replacing gelatin capsule completely, the market to widen starch capsule provides new research direction.
In order to achieve the above objectives, the technical solution adopted in the present invention is：One kind preparing starch using hair sweet potato starch as major ingredient
The method of capsule, includes the following steps：
(1) preparation of hair sweet potato starch：It counts in parts by weight, 1000 parts of hair potato slurries and 3~5 parts of cellulases is put into enzyme
It solves in tank, is passed through carbon dioxide gas and nitrogen gas, pressure is 0.2MPa~0.3MPa, temperature is 55 DEG C~70 DEG C
Under the conditions of digest 1h, then add 1~3 part of protease, under the conditions of 40 DEG C~55 DEG C constant pressure digest 2h~3h, make material
Viscosity reach 150mPa ﹒ s, obtain enzymolysis liquid, by enzymolysis liquid after centrifugal treating, taking precipitate washes clean is put into vacuum
In spray dryer, the hair sweet potato starch that water content is 0.3%~0.8% is obtained；
(2) preparation of porous-starch：It counts in parts by weight, 100 parts of hair sweet potato starch, 680~800 portions of enzymolysis buffer solutions is put
Enter in enzymatic vessel, under conditions of temperature is 65 DEG C~75 DEG C, mixing speed is 200r/min~400r/min react 4h~
5h, the pH value that reaction system is then adjusted with sodium hydroxide solution are 7.5~8.5, suspension are formed, by suspension sheet frame
After formula filter is filtered, takes filter residue to carry out infra-red drying processing, obtain porous-starch；
(3) preparation of capsule：It counts in parts by weight, by 100 parts of porous-starch, 25~35 parts of pure water, 5~10 portions of seaweed
Sour sodium, 1 part of emulsifier and 5 parts of collagens are put into reactor, and 95 DEG C are warming up to the heating rate of 5 DEG C/min, heating
2h~3h is stirred with the speed of 100r/min simultaneously, until material gelatinization completely is transparent, is cooled to room temperature, material is put into
Compression molding in mold, finally the dry 12h~for 24 hours at 40 DEG C, obtains the starch capsule that moisture content is 8%~12%.
In the present invention, as further explanation, the hair potato slurries described in step (1) are prepared by following methods：By weight
Number meter, after 100 parts of hair potato wedge stems are removed the peel, slice is put into immersion 10h~12h in running water, takes out, be put into ultra-fine grinding
In machine, 1000 parts of deionized waters are added, 35min~45min is stirred with the speed of 2000r/min~3000r/min, are formed viscous
Degree is the hair potato slurries of 500mPa ﹒ s.
In the present invention, as further explanation, carbon dioxide gas and the nitrogen gas described in step (1)
Volume ratio is 3：1.
In the present invention, as further explanation, the technological parameter of the centrifugal treating described in step (1) is in 1000r/
The speed centrifugal treating 10min of min.
In the present invention, as further explanation, the running parameter of the vacuum spray dehydrator described in step (1) is：Very
Reciprocal of duty cycle -0.06MPa, inlet air temperature be 85 DEG C and charging rate be 0.5m/min under conditions of be spray-dried.
In the present invention, as further explanation, the enzymolysis buffer solution described in step (2) is to use weight ratio for 1：50
The sodium acetate solution that complex enzyme and pH value are 6.5 mixes.
In the present invention, as further explanation, the complex enzyme is by being 10 by weight：1 alpha-amylase and different
Amylase mixes.
The function introduction of part material is as follows：
Cellulase is used to digest cellulose in the present invention.
Carbon dioxide gas is used to adjust the acidity of the pH value of material in the present invention.
Nitrogen gas is used as protective gas in the present invention, while being also used for increasing the gaseous environment pressure of enzymolysis.
Protease is used for enzymolysis protein matter in the present invention.
Sodium alginate is used as preparing the raw material of starch capsule, the mouth for being used as stabilizer, improving starch capsule in the present invention
Sense.
Collagen is used as preparing the raw material of starch capsule in the present invention.
The invention has the advantages that：
1, the method for preparing hair sweet potato starch of use of the present invention can not only efficiently digest the fiber in mao potato wedge stem
Element and protein reduce the content of total alkaloid in hair potato wedge stem, moreover it is possible to improve the recovery rate of hair sweet potato starch.The present invention first adopts
It is passed through the technological means of carbon dioxide gas in the enzymolysis process of cellulase and protease, the material of enzymolysis is made to be in
Weak acid environment promotes the progress of enzymolysis；Simultaneously under the conditions of the hyperbaric environment of nitrogen, total alkaloid is made to suffer oppression and be in
In anaerobic environment, the degradation of total alkaloid is promoted.Above-mentioned technological means can reduce total alkaloid in material, cellulose
With the content of protein, the recovery rate of hair sweet potato starch is improved, protein molecule is also reduced and is given birth to recuding sugars compound and dimension
The crosslinked probability of the drug ingedients such as plain C further shortens the disintegration time of starch capsule.At the same time, the technological means of enzymolysis
The viscosity of material can also be made to decline, the resistance of material mucus suffered in drying process is reduced, be conducive to follow-up porous-starch
The progress of preparation process.
2, the present invention can efficiently prepare porous-starch.Because using the skill of enzymolysis processing in the preparation process of above-mentioned hair sweet potato starch
Art means so that the ingredient of hair sweet potato starch is more pure, and hair sweet potato starch itself contains a large amount of diastase, therefore hair
Sweet potato starch only needs further to be digested under the compound enzyme effect that alpha-amylase and isoamylase are composed, and pH value is
So that starch is precipitated under the conditions of 7.5~8.5 low alkalinity, the internal structure of mao sweet potato starch can be protected as possible, avoid basicity mistake
Generation that is high and leading to starch denaturalization phenomenon, makes mao sweet potato starch have good water-retaining property.
3, the present invention prepares starch capsule using the technological means slowly to heat up, porous-starch can be precipitated in low ph value
Under precondition, the internal structure of starch is further protected, starch water-retaining property is made to tend towards stability.The present invention is with the slow of 5 DEG C/min
Slow heating rate prepares starch capsule, and the high heating rate of 10~20 DEG C more typical/min can make the molecular structure of starch
The variation of gradual adaptive temperature, avoid because temperature increase it is too fast due to lead to the molecular link fracture suddenly inside starch and generate
Water-retaining property reduce problem generation, further make starch capsule water-retaining property keep stablize.
4, pulping process of the present invention can efficiently prepare the hair potato slurries containing Nanoparticle, be follow-up hair
The preparation of sweet potato starch hides the foreshadowing.Hair potato is put into dispersed ultrafine machine by the present invention, utilizes 2000r/min~3000r/min's
Hair potato particle is sufficiently sheared by high mixing speed, formed Nanoparticle and it is fully dispersed in deionized water.Height stirring
Speed can effectively weaken the servo-actuated phenomenon of mao potato wedge stem, accelerate shearing dispersion effect, overcome mao potato slurries mucus compared with
Greatly, the shortcomings that particle is not easy to disperse hides the foreshadowing for the preparation of follow-up hair sweet potato starch.
【Specific implementation mode】
Embodiment 1：
1, early-stage preparations
The preparation of hair potato slurries：It counts in parts by weight, after 100 parts of hair potato wedge stems are removed the peel, slice is put into running water and impregnates
10h takes out, is put into ultra-fine grinding machine, and 1000 parts of deionized waters are added, and 35min, shape are stirred with the speed of 2000r/min
At the hair potato slurries that viscosity is 500mPa ﹒ s.
Digest the preparation of buffer solution：It counts in parts by weight, after mixing by 10 parts of alpha-amylases and 1 part of isoamylase,
The sodium acetate solution that 550 parts of pH value are 6.5 is added, after stirring evenly, obtains enzymolysis buffer solution.
By above-mentioned prepared substance in following preparation methods.
2, a kind of method preparing starch capsule as major ingredient using hair sweet potato starch, includes the following steps：
(1) preparation of hair sweet potato starch：It counts in parts by weight, 1000 parts of hair potato slurries and 3 parts of cellulases is put into enzymolysis
In tank, it is passed through carbon dioxide gas and nitrogen gas, digests 1h under conditions of pressure is 0.2MPa, temperature is 55 DEG C, then
1 part of protease is added, constant pressure digests 2h under the conditions of 40 DEG C, so that the viscosity of material is reached 150mPa ﹒ s, obtains enzymolysis liquid, will
For enzymolysis liquid after the speed centrifugal treating 10min of 1000r/min, taking precipitate washes clean is put into vacuum spray dehydrator
In, it is spray-dried, is obtained under conditions of vacuum degree -0.06MPa, inlet air temperature are 85 DEG C and charging rate is 0.5m/min
The hair sweet potato starch for being 0.3% to water content；The volume ratio of the carbon dioxide gas and the nitrogen gas is 3：1；Institute
The running parameter for the vacuum spray dehydrator stated is：
(2) preparation of porous-starch：It counts in parts by weight, 100 parts of hair sweet potato starch, 680 portions of enzymolysis buffer solutions is put into enzyme
It solves in tank, reacts 4h under conditions of temperature is 65 DEG C, mixing speed is 200r/min, then adjusted with sodium hydroxide solution
The pH value of reaction system is 7.5, forms suspension, after suspension is filtered with plate and frame filter, takes filter residue to carry out red
Outer drying process, obtains porous-starch；
(3) preparation of capsule：It counts in parts by weight, by 100 parts of porous-starch, 25 parts of pure water, 5 parts of sodium alginates, 1
Part emulsifier and 5 parts of collagens are put into reactor, and 95 DEG C are warming up to the heating rate of 5 DEG C/min, while heating with
The speed of 100r/min stirs 2h, until material gelatinization completely is transparent, is cooled to room temperature, material is put into mold and is molded
Molding, finally the dry 12h at 40 DEG C, obtains the starch capsule that moisture content is 12%.
Embodiment 2：
1, early-stage preparations
The preparation of hair potato slurries：It counts in parts by weight, after 100 parts of hair potato wedge stems are removed the peel, slice is put into running water and impregnates
10.5h takes out, is put into ultra-fine grinding machine, and 1000 parts of deionized waters are added, and 36min is stirred with the speed of 2200r/min,
Form the hair potato slurries that viscosity is 500mPa ﹒ s.
Digest the preparation of buffer solution：It counts in parts by weight, after mixing by 10 parts of alpha-amylases and 1 part of isoamylase,
The sodium acetate solution that 550 parts of pH value are 6.5 is added, after stirring evenly, obtains enzymolysis buffer solution.
By above-mentioned prepared substance in following preparation methods.
2, a kind of method preparing starch capsule as major ingredient using hair sweet potato starch, includes the following steps：
(1) preparation of hair sweet potato starch：It counts in parts by weight, 1000 parts of hair potato slurries and 3.4 parts of cellulases is put into enzyme
It solves in tank, is passed through carbon dioxide gas and nitrogen gas, 1h is digested under conditions of pressure is 0.23MPa, temperature is 60 DEG C,
Then 2 parts of protease are added, constant pressure digests 2.5h under the conditions of 45 DEG C, so that the viscosity of material is reached 150mPa ﹒ s, is digested
Liquid, by enzymolysis liquid after the speed centrifugal treating 10min of 1000r/min, it is dry to be put into vacuum spraying for taking precipitate washes clean
In dry machine, it is dry that spraying is carried out under conditions of vacuum degree -0.06MPa, inlet air temperature are 85 DEG C and charging rate is 0.5m/min
It is dry, obtain the hair sweet potato starch that water content is 0.4%；The volume ratio of the carbon dioxide gas and the nitrogen gas is
3：1；The running parameter of the vacuum spray dehydrator is：
(2) preparation of porous-starch：It counts in parts by weight, 100 parts of hair sweet potato starch, 700 portions of enzymolysis buffer solutions is put into enzyme
It solves in tank, 4.5h is reacted under conditions of temperature is 66 DEG C, mixing speed is 260r/min, then with sodium hydroxide solution tune
The pH value for saving reaction system is 7.7, forms suspension, after suspension is filtered with plate and frame filter, filter residue is taken to carry out
Infra-red drying processing, obtains porous-starch；
(3) preparation of capsule：It counts in parts by weight, by 100 parts of porous-starch, 30 parts of pure water, 6 parts of sodium alginates, 1
Part emulsifier and 5 parts of collagens are put into reactor, and 95 DEG C are warming up to the heating rate of 5 DEG C/min, while heating with
The speed of 100r/min stirs 2.5h, until material gelatinization completely is transparent, is cooled to room temperature, material is put into mould in mold
Molded, finally the dry 15h at 40 DEG C, obtains the starch capsule that moisture content is 11%.
Embodiment 3：
1, early-stage preparations
The preparation of hair potato slurries：It counts in parts by weight, after 100 parts of hair potato wedge stems are removed the peel, slice is put into running water and impregnates
11h takes out, is put into ultra-fine grinding machine, and 1000 parts of deionized waters are added, and 40min, shape are stirred with the speed of 2700r/min
At the hair potato slurries that viscosity is 500mPa ﹒ s.
Digest the preparation of buffer solution：It counts in parts by weight, after mixing by 10 parts of alpha-amylases and 1 part of isoamylase,
The sodium acetate solution that 550 parts of pH value are 6.5 is added, after stirring evenly, obtains enzymolysis buffer solution.
By above-mentioned prepared substance in following preparation methods.
2, a kind of method preparing starch capsule as major ingredient using hair sweet potato starch, includes the following steps：
(1) preparation of hair sweet potato starch：It counts in parts by weight, 1000 parts of hair potato slurries and 4.2 parts of cellulases is put into enzyme
It solves in tank, is passed through carbon dioxide gas and nitrogen gas, 1h is digested under conditions of pressure is 0.24MPa, temperature is 63 DEG C,
Then 2.5 parts of protease are added, constant pressure digests 3h under the conditions of 47 DEG C, so that the viscosity of material is reached 150mPa ﹒ s, is digested
Liquid, by enzymolysis liquid after the speed centrifugal treating 10min of 1000r/min, it is dry to be put into vacuum spraying for taking precipitate washes clean
In dry machine, it is dry that spraying is carried out under conditions of vacuum degree -0.06MPa, inlet air temperature are 85 DEG C and charging rate is 0.5m/min
It is dry, obtain the hair sweet potato starch that water content is 0.5%；The volume ratio of the carbon dioxide gas and the nitrogen gas is
3：1；The running parameter of the vacuum spray dehydrator is：
(2) preparation of porous-starch：It counts in parts by weight, 100 parts of hair sweet potato starch, 750 portions of enzymolysis buffer solutions is put into enzyme
It solves in tank, reacts 5h under conditions of temperature is 71 DEG C, mixing speed is 300r/min, then adjusted with sodium hydroxide solution
The pH value of reaction system is 7.8, forms suspension, after suspension is filtered with plate and frame filter, takes filter residue to carry out red
Outer drying process, obtains porous-starch；
(3) preparation of capsule：It counts in parts by weight, by 100 parts of porous-starch, 33 parts of pure water, 8 parts of sodium alginates, 1
Part emulsifier and 5 parts of collagens are put into reactor, and 95 DEG C are warming up to the heating rate of 5 DEG C/min, while heating with
The speed of 100r/min stirs 2h, until material gelatinization completely is transparent, is cooled to room temperature, material is put into mold and is molded
Molding, finally the dry 20h at 40 DEG C, obtains the starch capsule that moisture content is 9%.
Embodiment 4：
1, early-stage preparations
The preparation of hair potato slurries：It counts in parts by weight, after 100 parts of hair potato wedge stems are removed the peel, slice is put into running water and impregnates
11.5h takes out, is put into ultra-fine grinding machine, and 1000 parts of deionized waters are added, and 41min is stirred with the speed of 2600r/min,
Form the hair potato slurries that viscosity is 500mPa ﹒ s.
Digest the preparation of buffer solution：It counts in parts by weight, after mixing by 10 parts of alpha-amylases and 1 part of isoamylase,
The sodium acetate solution that 550 parts of pH value are 6.5 is added, after stirring evenly, obtains enzymolysis buffer solution.
By above-mentioned prepared substance in following preparation methods.
2, a kind of method preparing starch capsule as major ingredient using hair sweet potato starch, includes the following steps：
(1) preparation of hair sweet potato starch：It counts in parts by weight, 1000 parts of hair potato slurries and 3.8 parts of cellulases is put into enzyme
It solves in tank, is passed through carbon dioxide gas and nitrogen gas, 1h is digested under conditions of pressure is 0.27MPa, temperature is 65 DEG C,
Then 1.7 parts of protease are added, constant pressure digests 3h under the conditions of 48 DEG C, so that the viscosity of material is reached 150mPa ﹒ s, is digested
Liquid, by enzymolysis liquid after the speed centrifugal treating 10min of 1000r/min, it is dry to be put into vacuum spraying for taking precipitate washes clean
In dry machine, it is dry that spraying is carried out under conditions of vacuum degree -0.06MPa, inlet air temperature are 85 DEG C and charging rate is 0.5m/min
It is dry, obtain the hair sweet potato starch that water content is 0.6%；The volume ratio of the carbon dioxide gas and the nitrogen gas is
3：1；The running parameter of the vacuum spray dehydrator is：
(2) preparation of porous-starch：It counts in parts by weight, 100 parts of hair sweet potato starch, 750 portions of enzymolysis buffer solutions is put into enzyme
It solves in tank, 4.5h is reacted under conditions of temperature is 72 DEG C, mixing speed is 360r/min, then with sodium hydroxide solution tune
The pH value for saving reaction system is 8.1, forms suspension, after suspension is filtered with plate and frame filter, filter residue is taken to carry out
Infra-red drying processing, obtains porous-starch；
(3) preparation of capsule：It counts in parts by weight, by 100 parts of porous-starch, 32 parts of pure water, 8 parts of sodium alginates, 1
Part emulsifier and 5 parts of collagens are put into reactor, and 95 DEG C are warming up to the heating rate of 5 DEG C/min, while heating with
The speed of 100r/min stirs 2.5h, until material gelatinization completely is transparent, is cooled to room temperature, material is put into mould in mold
Molded, finally the dry 18h at 40 DEG C, obtains the starch capsule that moisture content is 10%.
Embodiment 5：
1, early-stage preparations
The preparation of hair potato slurries：It counts in parts by weight, after 100 parts of hair potato wedge stems are removed the peel, slice is put into running water and impregnates
10.5h takes out, is put into ultra-fine grinding machine, and 1000 parts of deionized waters are added, and 41min is stirred with the speed of 2700r/min,
Form the hair potato slurries that viscosity is 500mPa ﹒ s.
Digest the preparation of buffer solution：It counts in parts by weight, after mixing by 10 parts of alpha-amylases and 1 part of isoamylase,
The sodium acetate solution that 550 parts of pH value are 6.5 is added, after stirring evenly, obtains enzymolysis buffer solution.
By above-mentioned prepared substance in following preparation methods.
2, a kind of method preparing starch capsule as major ingredient using hair sweet potato starch, includes the following steps：
(1) preparation of hair sweet potato starch：It counts in parts by weight, 1000 parts of hair potato slurries and 4 parts of cellulases is put into enzymolysis
In tank, it is passed through carbon dioxide gas and nitrogen gas, digests 1h under conditions of pressure is 0.23MPa, temperature is 63 DEG C, so
After add 2 parts of protease, under the conditions of 49 DEG C constant pressure digest 2.5h, make material viscosity reach 150mPa ﹒ s, digested
Liquid, by enzymolysis liquid after the speed centrifugal treating 10min of 1000r/min, it is dry to be put into vacuum spraying for taking precipitate washes clean
In dry machine, it is dry that spraying is carried out under conditions of vacuum degree -0.06MPa, inlet air temperature are 85 DEG C and charging rate is 0.5m/min
It is dry, obtain the hair sweet potato starch that water content is 0.6%；The volume ratio of the carbon dioxide gas and the nitrogen gas is
3：1；The running parameter of the vacuum spray dehydrator is：
(2) preparation of porous-starch：It counts in parts by weight, 100 parts of hair sweet potato starch, 760 portions of enzymolysis buffer solutions is put into enzyme
It solves in tank, 4.5h is reacted under conditions of temperature is 72 DEG C, mixing speed is 380r/min, then with sodium hydroxide solution tune
The pH value for saving reaction system is 7.9, forms suspension, after suspension is filtered with plate and frame filter, filter residue is taken to carry out
Infra-red drying processing, obtains porous-starch；
(3) preparation of capsule：It counts in parts by weight, by 100 parts of porous-starch, 32 parts of pure water, 8 parts of sodium alginates, 1
Part emulsifier and 5 parts of collagens are put into reactor, and 95 DEG C are warming up to the heating rate of 5 DEG C/min, while heating with
The speed of 100r/min stirs 2.5h, until material gelatinization completely is transparent, is cooled to room temperature, material is put into mould in mold
Molded, finally the dry 19h at 40 DEG C, obtains the starch capsule that moisture content is 9%.
Embodiment 6：
1, early-stage preparations
The preparation of hair potato slurries：It counts in parts by weight, after 100 parts of hair potato wedge stems are removed the peel, slice is put into running water and impregnates
12h takes out, is put into ultra-fine grinding machine, and 1000 parts of deionized waters are added, and 45min, shape are stirred with the speed of 3000r/min
At the hair potato slurries that viscosity is 500mPa ﹒ s.
Digest the preparation of buffer solution：It counts in parts by weight, after mixing by 10 parts of alpha-amylases and 1 part of isoamylase,
The sodium acetate solution that 550 parts of pH value are 6.5 is added, after stirring evenly, obtains enzymolysis buffer solution.
By above-mentioned prepared substance in following preparation methods.
2, a kind of method preparing starch capsule as major ingredient using hair sweet potato starch, includes the following steps：
(1) preparation of hair sweet potato starch：It counts in parts by weight, 1000 parts of hair potato slurries and 5 parts of cellulases is put into enzymolysis
In tank, it is passed through carbon dioxide gas and nitrogen gas, digests 1h under conditions of pressure is 0.3MPa, temperature is 70 DEG C, then
3 parts of protease are added, constant pressure digests 3h under the conditions of 55 DEG C, so that the viscosity of material is reached 150mPa ﹒ s, obtains enzymolysis liquid, will
For enzymolysis liquid after the speed centrifugal treating 10min of 1000r/min, taking precipitate washes clean is put into vacuum spray dehydrator
In, it is spray-dried, is obtained under conditions of vacuum degree -0.06MPa, inlet air temperature are 85 DEG C and charging rate is 0.5m/min
The hair sweet potato starch for being 0.8% to water content；The volume ratio of the carbon dioxide gas and the nitrogen gas is 3：1；Institute
The running parameter for the vacuum spray dehydrator stated is：
(2) preparation of porous-starch：It counts in parts by weight, 100 parts of hair sweet potato starch, 800 portions of enzymolysis buffer solutions is put into enzyme
It solves in tank, reacts 5h under conditions of temperature is 75 DEG C, mixing speed is 400r/min, then adjusted with sodium hydroxide solution
The pH value of reaction system is 8.5, forms suspension, after suspension is filtered with plate and frame filter, takes filter residue to carry out red
Outer drying process, obtains porous-starch；
(3) preparation of capsule：It counts in parts by weight, by 100 parts of porous-starch, 35 parts of pure water, 10 parts of sodium alginates, 1
Part emulsifier and 5 parts of collagens are put into reactor, and 95 DEG C are warming up to the heating rate of 5 DEG C/min, while heating with
The speed of 100r/min stirs 3h, until material gelatinization completely is transparent, is cooled to room temperature, material is put into mold and is molded
Molding, finally drying for 24 hours, obtains the starch capsule that moisture content is 8% at 40 DEG C.
Comparative example 1：Specific preparation method is substantially the same manner as Example 1, and difference is：The preparation process of hair sweet potato starch
In do not have using being passed through the technological means of carbon dioxide gas and nitrogen gas；
Comparative example 2：Specific preparation method is substantially the same manner as Example 1, and difference is：The preparation process of porous-starch
Is porous-starch is precipitated under conditions of 10.0 in the middle pH value used；
Comparative example 3：Specific preparation method is substantially the same manner as Example 1, and difference is：The preparation process of starch capsule
The middle heating rate used is 10~20 DEG C/min；
Contrast test 1：
Capsule disintegrating property measures：Disintegration time limited refers to solid pharmaceutical preparation in the regulation method of inspection and liquid medium, disintegration
To less than the limit the time required to 2.0mm powders.Capsule disintegrating property simulated experiment is carried out according to document.Take made capsule 6
Grain, fills talcum powder, after fitting, is placed in the glass tube of hanging basket, and disintegration liquid uses the phosphate buffer solution of pH value 6.8,
Under (37 ± 0.5) DEG C temperature condition, when starch capsule detection prepared by comparative example 1-3 and embodiment 1-6 being selected to be disintegrated respectively
Limit.5 repetitions are done respectively, its average value, specific testing result is taken to be shown in Table 1.
Contrast test 2：
Rate-of-loss of coolant is tested：Rate-of-loss of coolant refers to the matter of unit mass water-retaining agent lost moisture within the flat evaporator time
Amount weighs each 20g of starch capsule prepared by comparative example 1-3 and embodiment 1-6, waits for that it absorbs water to saturation, claims mass M a.It is placed in
Constant temperature forced air drying (30 DEG C) in electric heating constant-temperature blowing drying box claim mass M b when time interval is 96h.Meanwhile record is each
Starch capsule reaches the time of permanent quality.According to formula rate-of-loss of coolant=(Ma-Mb)/Ma, rate-of-loss of coolant is calculated (when a represents initial
Between point；B represents time point to be measured).
Table 1
| Disintegration time limited/min | Percentage of water loss/% | |
| Comparative example 1 | 6.5 | 0.114 |
| Comparative example 2 | 5.0 | 0.102 |
| Comparative example 3 | 8.0 | 0.168 |
| Embodiment 1 | 2.5 | 0.001 |
| Embodiment 2 | 3.0 | 0.001 |
| Embodiment 3 | 2.0 | 0.002 |
| Embodiment 4 | 2.5 | 0.001 |
| Embodiment 5 | 3.0 | 0.001 |
| Embodiment 6 | 3.0 | 0.002 |
Table 1 the result shows that：Disintegration time is shorter, illustrates that mao disintegration of sweet potato starch capsule is better, amylan is intracapsular
Drug is more early to play a role.The disintegration time longest of comparative example 2, the disintegration time of embodiment 3 is most short, illustrates to pass through amylan
It uses heating rate for the technological means of 5 DEG C/min slowly to heat up in the preparation process of capsule, significant decrease starch can be reached
The purpose of the disintegration time of capsule；
Percentage of water loss is lower, illustrates that mao water-retaining property of sweet potato starch capsule is better.The percentage of water loss highest of comparative example 3, embodiment 1,
Embodiment 2, embodiment 4, the percentage of water loss of embodiment 5 are minimum, illustrate to use heating rate in the preparation process by starch capsule
For the technological means of 5 DEG C/min slowly to heat up, can reach significantly reduces the percentage of water loss of starch capsule, improves water-retaining property
Purpose.
Above description is the detailed description for the present invention preferably possible embodiments, but embodiment is not limited to this hair
Bright patent claim, it is all the present invention suggested by technical spirit under completed same changes or modifications change, should all belong to
In the covered the scope of the claims of the present invention.
Claims (7)
1. a kind of method preparing starch capsule as major ingredient using hair sweet potato starch, it is characterised in that：Include the following steps：
(1) preparation of hair sweet potato starch：It counts in parts by weight, 1000 parts of hair potato slurries and 3~5 parts of cellulases is put into enzymatic vessel
In, it is passed through carbon dioxide gas and nitrogen gas, under conditions of pressure is 0.2MPa~0.3MPa, temperature is 55 DEG C~70 DEG C
1h is digested, 1~3 part of protease is then added, constant pressure digests 2h~3h under the conditions of 40 DEG C~55 DEG C, and the viscosity of material is made to reach
150mPa ﹒ s, obtain enzymolysis liquid, and by enzymolysis liquid after centrifugal treating, taking precipitate washes clean is put into vacuum spray drying
In machine, the hair sweet potato starch that water content is 0.3%~0.8% is obtained；
(2) preparation of porous-starch：It counts in parts by weight, 100 parts of hair sweet potato starch, 680~800 portions of enzymolysis buffer solutions is put into enzyme
It solves in tank, 4h~5h is reacted under conditions of temperature is 65 DEG C~75 DEG C, mixing speed is 200r/min~400r/min, then
The pH value that reaction system is adjusted with sodium hydroxide solution is 7.5~8.5, suspension is formed, by suspension plate and frame filter
After being filtered, takes filter residue to carry out infra-red drying processing, obtain porous-starch；
(3) preparation of capsule：It counts in parts by weight, by 100 parts of porous-starch, 25~35 parts of pure water, 5~10 parts of alginic acids
Sodium, 1 part of emulsifier and 5 parts of collagens are put into reactor, and 95 DEG C are warming up to the heating rate of 5 DEG C/min, heating it is same
When 2h~3h stirred with the speed of 100r/min, until material gelatinization completely is transparent, is cooled to room temperature, material be put into mould
Compression molding in tool, finally the dry 12h~for 24 hours at 40 DEG C, obtains the starch capsule that moisture content is 8%~12%.
2. a kind of method preparing starch capsule as major ingredient using hair sweet potato starch according to claim 1, it is characterised in that：Step
Suddenly the hair potato slurries described in (1) are prepared by following methods：It counts in parts by weight, after 100 parts of hair potato wedge stems are removed the peel, slice is put
Enter in running water immersion 10h~12h, take out, be put into ultra-fine grinding machine, 1000 parts of deionized waters are added, with 2000r/min~
The speed of 3000r/min stirs 35min~45min, forms the hair potato slurries that viscosity is 500mPa ﹒ s.
3. a kind of method preparing starch capsule as major ingredient using hair sweet potato starch according to claim 1, it is characterised in that：Step
Suddenly the volume ratio of the carbon dioxide gas described in (1) and the nitrogen gas is 3：1.
4. a kind of method preparing starch capsule as major ingredient using hair sweet potato starch according to claim 1, it is characterised in that：Step
Suddenly the technological parameter of the centrifugal treating described in (1) is the speed centrifugal treating 10min in 1000r/min.
5. a kind of method preparing starch capsule as major ingredient using hair sweet potato starch according to claim 1, it is characterised in that：Step
Suddenly the running parameter of the vacuum spray dehydrator described in (1) is：Vacuum degree -0.06MPa, inlet air temperature are 85 DEG C and charging rate
To be spray-dried under conditions of 0.5m/min.
6. a kind of method preparing starch capsule as major ingredient using hair sweet potato starch according to claim 1, it is characterised in that：Step
Suddenly the enzymolysis buffer solution described in (2) is to use weight ratio for 1：50 complex enzyme and pH value for 6.5 sodium acetate solution mixing and
At.
7. a kind of method preparing starch capsule as major ingredient using hair sweet potato starch according to claim 6, it is characterised in that：Institute
The complex enzyme stated is by being 10 by weight：1 alpha-amylase and isoamylase mixes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810320071.8A CN108283627A (en) | 2018-04-11 | 2018-04-11 | A method of preparing starch capsule by major ingredient of hair sweet potato starch |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810320071.8A CN108283627A (en) | 2018-04-11 | 2018-04-11 | A method of preparing starch capsule by major ingredient of hair sweet potato starch |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108283627A true CN108283627A (en) | 2018-07-17 |
Family
ID=62834428
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810320071.8A Pending CN108283627A (en) | 2018-04-11 | 2018-04-11 | A method of preparing starch capsule by major ingredient of hair sweet potato starch |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108283627A (en) |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1236885A (en) * | 1968-09-28 | 1971-06-23 | Fuji Photo Film Co Ltd | Method of making multi-wall capsules |
| CN1911966A (en) * | 2006-08-23 | 2007-02-14 | 华南理工大学 | Pretreatment method of starch |
| CN101942119A (en) * | 2010-09-28 | 2011-01-12 | 武汉绿舟环保科技有限公司 | Modified starch catalyzed by compound bio-enzymes and preparation method and application thereof |
| CN103830736A (en) * | 2014-03-05 | 2014-06-04 | 中国科学院青岛生物能源与过程研究所 | Production method of starch empty capsule |
| CN104805156A (en) * | 2015-05-13 | 2015-07-29 | 宜春学院 | Preparation method for dioscorea batatas decne resistant starch |
| CN106751922A (en) * | 2016-12-11 | 2017-05-31 | 孙祎 | A kind of preparation method of the resistance to embrittlement capsule shells of biomass |
| CN107456581A (en) * | 2017-08-11 | 2017-12-12 | 广西壮族自治区农业科学院农业资源与环境研究所 | A kind of selenium-rich rice Selenium in Plants protein capsule material and preparation method thereof |
-
2018
- 2018-04-11 CN CN201810320071.8A patent/CN108283627A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1236885A (en) * | 1968-09-28 | 1971-06-23 | Fuji Photo Film Co Ltd | Method of making multi-wall capsules |
| CN1911966A (en) * | 2006-08-23 | 2007-02-14 | 华南理工大学 | Pretreatment method of starch |
| CN101942119A (en) * | 2010-09-28 | 2011-01-12 | 武汉绿舟环保科技有限公司 | Modified starch catalyzed by compound bio-enzymes and preparation method and application thereof |
| CN103830736A (en) * | 2014-03-05 | 2014-06-04 | 中国科学院青岛生物能源与过程研究所 | Production method of starch empty capsule |
| CN104805156A (en) * | 2015-05-13 | 2015-07-29 | 宜春学院 | Preparation method for dioscorea batatas decne resistant starch |
| CN106751922A (en) * | 2016-12-11 | 2017-05-31 | 孙祎 | A kind of preparation method of the resistance to embrittlement capsule shells of biomass |
| CN107456581A (en) * | 2017-08-11 | 2017-12-12 | 广西壮族自治区农业科学院农业资源与环境研究所 | A kind of selenium-rich rice Selenium in Plants protein capsule material and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 何娇，等: "毛薯粉浆酶法水解的响应面法优化及其动力学研究", 《食品科学》 * |
| 潘颉: "木薯微孔淀粉微胶囊化罗非鱼技术研究", 《中国优秀硕士学位论文全文数据库工程科技Ⅰ辑》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104187746B (en) | The technique that fermentation method prepares Testa Phaseoli radiati water soluble dietary fiber | |
| CN108740283B (en) | Preparation method of high-whiteness injection type soybean protein isolate | |
| CN106722501B (en) | Preparation method of mango peel residue dietary fiber and application of obtained product | |
| CN104472851A (en) | Method for producing selenium-enriched protein powder by treating selenium-enriched rice in enzymatic method | |
| CN106858593A (en) | A kind of double ginseng colla corii asini cakes and preparation method thereof | |
| CN109288072A (en) | A kind of preparation method of mandarin orange pomace nano-dietary fiber | |
| CN108948227A (en) | A kind of method that high-voltage pulse extracts okra pectin | |
| CN108902676A (en) | Wheat-based polypeptide and modified starch compounding wheat analogies and preparation method thereof | |
| CN104031172A (en) | Method for extracting pectin from banana peel by ultrasonic synergistic ammonium oxalate method | |
| CN112029603A (en) | Fructus cannabis beer and preparation method thereof | |
| CN105104989B (en) | High cyanine vegetarian noodles and preparation method thereof | |
| CN111000181B (en) | Preparation method of black tea jelly | |
| CN109287905A (en) | Fermented type soybean residue beverage preparation method | |
| CN107495327A (en) | Instant tremella wall cell disruption powder and preparation method | |
| CN108283627A (en) | A method of preparing starch capsule by major ingredient of hair sweet potato starch | |
| CN106262322A (en) | The processing method of red ferrum fruit nourishing jam powder | |
| CN108659136B (en) | A kind of preparation process of high-efficiency low-toxicity hair sweet potato starch | |
| CN103518943A (en) | Method for extracting proteins from rape seed cakes by utilizing multi-frequency ultrasonic waves | |
| CN105285587A (en) | Pear vinegar beverage containing green tea polysaccharide and preparation method of pear vinegar beverage | |
| CN107259511A (en) | A kind of preparation method without alum sweet potato noodles | |
| CN107114553A (en) | A kind of production method of high-purity black rice albumen | |
| CN108587331A (en) | A kind of special white-out agent of citrus fruit | |
| CN107034075A (en) | The brewing method of Fructus Corni sun lotus health liquor | |
| CN111000182B (en) | Preparation method of Pu' er tea jelly | |
| CN103451254A (en) | Method for preparing gingko microporous starch with high specific surface area by bio-enzyme method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180717 |
|
| RJ01 | Rejection of invention patent application after publication |