CN108272933A - Infantile heat-clearing and antitussive ball and preparation method thereof - Google Patents
Infantile heat-clearing and antitussive ball and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to a kind of infantile heat-clearing and antitussive balls and preparation method thereof, belong to technical field of Chinese patent medicine, it is intended to reduce the hydroscopicity of infantile heat-clearing and antitussive ball.This kind of infantile heat-clearing and antitussive ball, is mixed by Chinese medicine material and refined honey；The Chinese medicine material, it counts in parts by weight, including 85 95 parts of Chinese ephedra, 70 80 parts of frying semen armeniacae amarae, 160 200 parts of gypsum, 43 47 parts of Radix Glycyrrhizae, 85 95 parts of frying perilla seed, 85 95 parts of lepidium seed, 43 47 parts of frying radish seed, 70 80 parts of Cynanchum glaucescens, 70 80 parts of arisaema cum bile, 43 47 parts of radix scutellariae of wine toast, 140 160 parts of jujube；Modified starch is added in the refined honey.Hydroscopicity is relatively low before the deadline for the infantile heat-clearing and antitussive ball being prepared, and ensure that the quality of infantile heat-clearing and antitussive ball.
Description
Technical field
The present invention relates to technical field of Chinese patent medicine, more specifically, it is related to a kind of infantile heat-clearing and antitussive ball and preparation method thereof.
Background technology
Chinese Pharmacopoeia one, which records infantile heat-clearing and antitussive ball, has the effect of heat-clearing, resolving sputum, Dingchuan.It is mainly used for treating small
The cough with lung heat of youngster, abundant expectoration asthma.The preparation process of infantile heat-clearing and antitussive ball is to enter fecula in Chinese Pharmacopoeia preparation method
Medicine is added refined honey and big honeyed bolus is made later.
Honey is in thick, and white crystals particle is long placed in or can be precipitated to the cold for transparent either translucent liquid,
Fragrant, sweet flavor, through being used frequently as excipient or corrigent in Chinese medicine preparation.Honey can not only mitigate medicine
Property, increase drug the effect of.
Wherein, 70% or more be glucose and fructose in honey, fructose is easy to moisture absorption compared with glucose, although this is because it
It is identical as the hydroxy number of glucose, but the hydrogen bonding site of glucose has formd the sugared hydrogen bond of sugar-, therefore, honey
Itself is easy moisture absorption.The honey usage amount of honeyed bolus is larger, therefore, during making and storage, refined honey easy to absorb moisture, so as to cause
Refined honey moldy metamorphism, the effect of influencing infantile heat-clearing and antitussive ball.
Therefore, in the manufacturing process of infantile heat-clearing and antitussive ball, controlling the quality of refined honey is necessary, research and development one
Kind quality is good, and the infantile heat-clearing and antitussive ball for preventing from occurring denaturalization phenomenon before the deadline is very necessary.
Invention content
The purpose of the present invention is to provide a kind of infantile heat-clearing and antitussive ball, this kind of infantile heat-clearing and antitussive ball is inhaled before the deadline
Wet rate is relatively low, ensure that the quality of infantile heat-clearing and antitussive ball.
The present invention above-mentioned purpose technical scheme is that：A kind of infantile heat-clearing and antitussive ball, in
Medicine raw material is mixed with refined honey；The Chinese medicine material, is counted in parts by weight, including 85-95 parts of Chinese ephedra, frying semen armeniacae amarae 70-
80 parts, 160-200 parts of gypsum, 43-47 parts of Radix Glycyrrhizae, 85-95 parts of frying perilla seed, 85-95 parts of lepidium seed, frying radish seed 43-
47 parts, 70-80 parts of Cynanchum glaucescens, 70-80 parts of arisaema cum bile, wine toast 43-47 parts of radix scutellariae, 140-160 parts of jujube；It is added and changes in the refined honey
Property starch.
Preferably, the mass ratio of the Chinese medicine material and refined honey is 1:0.6-0.7.
Preferably, the mass ratio of the refined honey and modified starch is 5:2.
Preferably, 90 parts of Chinese ephedra, 75 parts of frying semen armeniacae amarae, 180 parts of gypsum, 45 parts of Radix Glycyrrhizae, 90 parts of frying perilla seed, Roripa montana
90 parts of son, 45 parts of frying radish seed, 75 parts of Cynanchum glaucescens, 75 parts of arisaema cum bile, 45 parts of radix scutellariae of wine toast, 150 parts of jujube.
Another object of the present invention is to provide the preparation methods of infantile heat-clearing and antitussive ball described above.
The present invention above-mentioned purpose technical scheme is that, a kind of preparation of infantile heat-clearing and antitussive ball
Method includes the following steps:
Chinese medicine material is prepared：Take Chinese ephedra, frying semen armeniacae amarae, gypsum, Radix Glycyrrhizae, frying perilla seed, lepidium seed, frying radish seed, white
Before, arisaema cum bile, wine toast radix scutellariae, jujube, be ground into fine powder, mixing is rear to be sieved；
Refined honey:Fresh Honey is taken, honey is heated to 116-118 DEG C, until when there is the uniformly product of faint yellow thin bubble, is stopped
Only heat；
Starch conversion：Extracting corn starch, ethyl alcohol, sodium hydroxide, water after uniform stirring, increase temperature of reaction system to 40-42
DEG C, after reacting 1.2-1.4h, monoxone is added in reaction system, after the reaction was continued later 2-2.4h, reaction system is cooled down
To room temperature, the acid-base value of reaction system is adjusted to neutrality, is washed later with 80% ethanol solution, after dry, crush；
It is prepared by infantile heat-clearing and antitussive ball：Modified starch, refined honey are taken, under conditions of pressure is 30MPa, inlet air temperature is 170 DEG C,
Under conditions of leaving air temp is 65 DEG C, is dried, Chinese medicine material be added later, after mixing, pill, it is dry to get.
Preferably, 60-90 mesh sieve is crossed after Chinese medicine material grinding.
Preferably, in the starch conversion step, cornstarch, ethyl alcohol, sodium hydroxide, water, chloroacetic mass ratio are
100:56:23:300:26。
Preferably, in the starch conversion step, after completion of the reaction, the pH to 7-7.2 of reaction system is adjusted.
In conclusion the invention has the advantages that：
1, hydroscopicity is relatively low before the deadline for the infantile heat-clearing and antitussive ball that the present invention is prepared, and ensure that infantile heat-clearing and antitussive ball
Quality.
2, for the present invention during preparing infantile heat-clearing and antitussive ball, modified cornstarch is former by refined honey and Chinese medicine
Feed powder end coats, and reduces the contact area of refined honey and air, meanwhile, modified cornstarch is combined with the moisture in air
Reduced capability, therefore modified cornstarch has apparent inhibiting effect to the hygroscopicity of infantile heat-clearing and antitussive ball, ensure that
The quality of infantile heat-clearing and antitussive ball before the deadline.
Specific implementation mode
Involved all substances are commercially available in the embodiment of the present invention.
One, embodiment is made.
Embodiment 1
Chinese medicine material is prepared：Take Chinese ephedra 90kg, frying semen armeniacae amarae 75kg, gypsum 180kg, Radix Glycyrrhizae 45kg, frying perilla seed 90kg,
Lepidium seed 90kg, frying radish seed 45kg, Cynanchum glaucescens 75kg, arisaema cum bile 75kg, wine toast radix scutellariae 45kg, jujube 150kg, are ground into thin
Powder, mixing, 75 mesh of rear mistake sieve；
Refined honey:Fresh Honey is taken, honey is heated to 117 DEG C, until when there is the uniformly product of faint yellow thin bubble, stops adding
Heat；Starch conversion：Extracting corn starch 100kg, ethyl alcohol 56kg, sodium hydroxide 23kg, water 300kg after uniform stirring, increase reaction
System temperature is to 41 DEG C, after reacting 1.3h, is added monoxone 26kg in reaction system, will be anti-after the reaction was continued later 2.2h
It answers system to be cooled to room temperature, adjusts the pH to 7.1 of reaction system, washed later with 80% ethanol solution, after dry, crush；
It is prepared by infantile heat-clearing and antitussive ball：Modified starch 24kg, refined honey 60kg are taken, under conditions of pressure is 30MPa, inlet air temperature
It is 170 DEG C, under conditions of leaving air temp is 65 DEG C, is dried, Chinese medicine material 100kg is added later, after mixing, system
Ball, it is dry to get.
Embodiment 2
Chinese medicine material is prepared：Take Chinese ephedra 85kg, frying semen armeniacae amarae 70kg, gypsum 160kg, Radix Glycyrrhizae 47kg, frying perilla seed 95kg,
Lepidium seed 85kg, frying radish seed 45kg, Cynanchum glaucescens 80kg, arisaema cum bile 70kg, wine toast radix scutellariae 43kg, jujube 140kg, are ground into thin
Powder, mixing, 75 mesh of rear mistake sieve；
Refined honey:Fresh Honey is taken, honey is heated to 118 DEG C, until when there is the uniformly product of faint yellow thin bubble, stops adding
Heat；Starch conversion：Extracting corn starch 90kg, ethyl alcohol 54kg, sodium hydroxide 21kg, water 280kg after uniform stirring, increase reaction
System temperature is to 42 DEG C, after reacting 1.4h, is added monoxone 24kg in reaction system, will be anti-after the reaction was continued later 2.2h
It answers system to be cooled to room temperature, adjusts the pH to 7.2 of reaction system, washed later with 80% ethanol solution, after dry, crush；
It is prepared by infantile heat-clearing and antitussive ball：Modified starch 28kg, refined honey 70kg are taken, under conditions of pressure is 30MPa, inlet air temperature
It is 170 DEG C, under conditions of leaving air temp is 65 DEG C, is dried, Chinese medicine material 100kg is added later, after mixing, system
Ball, it is dry to get.
Embodiment 3
Chinese medicine material is prepared：Take Chinese ephedra 95kg, frying semen armeniacae amarae 70kg, gypsum 160kg, Radix Glycyrrhizae 47kg, frying perilla seed 85kg,
Lepidium seed 95kg, frying radish seed 47kg, Cynanchum glaucescens 80kg, arisaema cum bile 70kg, wine toast radix scutellariae 47kg, jujube 140kg, are ground into thin
Powder, mixing, 90 mesh of rear mistake sieve；
Refined honey:Fresh Honey is taken, honey is heated to 118 DEG C, until when there is the uniformly product of faint yellow thin bubble, stops adding
Heat；Starch conversion：Extracting corn starch 90kg, ethyl alcohol 58kg, sodium hydroxide 21kg, water 280kg after uniform stirring, increase reaction
System temperature is to 42 DEG C, after reacting 1.2h, is added monoxone 28kg in reaction system, will be anti-after the reaction was continued later 2.4h
It answers system to be cooled to room temperature, adjusts the pH to 7.2 of reaction system, washed later with 80% ethanol solution, after dry, crush；
It is prepared by infantile heat-clearing and antitussive ball：Modified starch 28kg, refined honey 65kg are taken, under conditions of pressure is 30MPa, inlet air temperature
It is 170 DEG C, under conditions of leaving air temp is 65 DEG C, is dried, Chinese medicine material 100kg is added later, after mixing, system
Ball, it is dry to get.
Embodiment 4
Chinese medicine material is prepared：Take Chinese ephedra 85kg, frying semen armeniacae amarae 70kg, gypsum 200kg, Radix Glycyrrhizae 43kg, frying perilla seed 95kg,
Lepidium seed 90kg, frying radish seed 43kg, Cynanchum glaucescens 75kg, arisaema cum bile 80kg, wine toast radix scutellariae 43kg, jujube 140kg, are ground into thin
Powder, mixing, 60 mesh of rear mistake sieve；
Refined honey:Fresh Honey is taken, honey is heated to 117 DEG C, until when there is the uniformly product of faint yellow thin bubble, stops adding
Heat；Starch conversion：Extracting corn starch 110kg, ethyl alcohol 54kg, sodium hydroxide 21kg, water 320kg after uniform stirring, increase reaction
System temperature is to 40 DEG C, after reacting 1.4h, is added monoxone 26kg in reaction system, after the reaction was continued later 2h, will react
System is cooled to room temperature, and is adjusted the pH to 7.1 of reaction system, is washed later with 80% ethanol solution, after dry, is crushed；
It is prepared by infantile heat-clearing and antitussive ball：Modified starch 28kg, refined honey 70kg are taken, under conditions of pressure is 30MPa, inlet air temperature
It is 170 DEG C, under conditions of leaving air temp is 65 DEG C, is dried, Chinese medicine material 100kg is added later, after mixing, system
Ball, it is dry to get.
Embodiment 5
Chinese medicine material is prepared：Take Chinese ephedra 95kg, frying semen armeniacae amarae 80kg, gypsum 200kg, Radix Glycyrrhizae 43kg, frying perilla seed 85kg,
Lepidium seed 85kg, frying radish seed 45kg, Cynanchum glaucescens 75kg, arisaema cum bile 80kg, wine toast radix scutellariae 47kg, jujube 160kg, are ground into thin
Powder, mixing, 75 mesh of rear mistake sieve；
Refined honey:Fresh Honey is taken, honey is heated to 117 DEG C, until when there is the uniformly product of faint yellow thin bubble, stops adding
Heat；Starch conversion：Extracting corn starch 110kg, ethyl alcohol 58kg, sodium hydroxide 25kg, water 320kg after uniform stirring, increase reaction
System temperature is to 40 DEG C, after reacting 1.2h, is added monoxone 24kg in reaction system, will be anti-after the reaction was continued later 2.2h
It answers system to be cooled to room temperature, adjusts the pH to 7.1 of reaction system, washed later with 80% ethanol solution, after dry, crush；
It is prepared by infantile heat-clearing and antitussive ball：Modified starch 26kg, refined honey 65kg are taken, under conditions of pressure is 30MPa, inlet air temperature
It is 170 DEG C, under conditions of leaving air temp is 65 DEG C, is dried, Chinese medicine material 100kg is added later, after mixing, system
Ball, it is dry to get.
Embodiment 6
Chinese medicine material is prepared：Take Chinese ephedra 85kg, frying semen armeniacae amarae 80kg, gypsum 160kg, Radix Glycyrrhizae 43kg, frying perilla seed 95kg,
Lepidium seed 95kg, frying radish seed 47kg, Cynanchum glaucescens 70kg, arisaema cum bile 80kg, wine toast radix scutellariae 43kg, jujube 160kg, are ground into thin
Powder, mixing, 90 mesh of rear mistake sieve；
Refined honey:Fresh Honey is taken, honey is heated to 116 DEG C, until when there is the uniformly product of faint yellow thin bubble, stops adding
Heat；Starch conversion：Extracting corn starch 110kg, ethyl alcohol 54kg, sodium hydroxide 25kg, water 280kg after uniform stirring, increase reaction
System temperature is to 40 DEG C, after reacting 1.4h, is added monoxone 28kg in reaction system, will be anti-after the reaction was continued later 2.4h
It answers system to be cooled to room temperature, adjusts the pH to 7 of reaction system, washed later with 80% ethanol solution, after dry, crush；
It is prepared by infantile heat-clearing and antitussive ball：Modified starch 26kg, refined honey 70kg are taken, under conditions of pressure is 30MPa, inlet air temperature
It is 170 DEG C, under conditions of leaving air temp is 65 DEG C, is dried, Chinese medicine material 100kg is added later, after mixing, system
Ball, it is dry to get.
Two, comparative example is made.
Comparative example 1
Chinese medicine material is prepared：Take Chinese ephedra 90kg, frying semen armeniacae amarae 75kg, gypsum 180kg, Radix Glycyrrhizae 45kg, frying perilla seed 90kg,
Lepidium seed 90kg, frying radish seed 45kg, Cynanchum glaucescens 75kg, arisaema cum bile 75kg, wine toast radix scutellariae 45kg, jujube 150kg, are ground into thin
Powder, mixing, 75 mesh of rear mistake sieve；
Refined honey:Fresh Honey is taken, honey is heated to 117 DEG C, until when there is the uniformly product of faint yellow thin bubble, stops adding
Heat；It is prepared by infantile heat-clearing and antitussive ball：Refined honey 84kg is taken, under conditions of pressure is 30MPa, inlet air temperature is 170 DEG C, goes out wind-warm syndrome
Chinese medicine material 100kg is added under conditions of 65 DEG C, to be dried in degree later, after mixing, pill, it is dry to get.
Comparative example 2
Chinese medicine material is prepared：Take Chinese ephedra 90kg, frying semen armeniacae amarae 75kg, gypsum 180kg, Radix Glycyrrhizae 45kg, frying perilla seed 90kg,
Lepidium seed 90kg, frying radish seed 45kg, Cynanchum glaucescens 75kg, arisaema cum bile 75kg, wine toast radix scutellariae 45kg, jujube 150kg, are ground into thin
Powder, mixing, 75 mesh of rear mistake sieve；
Refined honey:Fresh Honey is taken, honey is heated to 117 DEG C, until when there is the uniformly product of faint yellow thin bubble, stops adding
Heat；It is prepared by infantile heat-clearing and antitussive ball：Extracting corn starch 24kg, refined honey 60kg, under conditions of pressure is 30MPa, inlet air temperature
It is 170 DEG C, under conditions of leaving air temp is 65 DEG C, is dried, Chinese medicine material 100kg is added later, after mixing, system
Ball, it is dry to get.
Three, the performance of the infantile heat-clearing and antitussive ball to being prepared in above example and comparative example is tested.
Evaluation index and detection method used by infantile heat-clearing and antitussive ball prepared by the above various embodiments and comparative example
It is as follows：Hydroscopicity：The infantile heat-clearing and antitussive ball sample being prepared in each embodiment and comparative example is taken, constant weight is respectively placed in
It in measuring cup, is put in glass desicator after accurate weighing, hydroscopicity is measured under conditions of being 60% in humidity.
The performance indicator of the above various embodiments and comparative example is as shown in table 1.
The performance test results for the infantile heat-clearing and antitussive ball that 1 each embodiment of table is prepared with comparative example
As can be seen from the above table, hydroscopicity is relatively low before the deadline for the infantile heat-clearing and antitussive ball that the present invention is prepared, and ensures
The quality of infantile heat-clearing and antitussive ball.
This specific embodiment is only explanation of the invention, is not limitation of the present invention, people in the art
Member can as needed make the present embodiment the modification of not creative contribution after reading this specification, but as long as at this
It is all protected by Patent Law in the right of invention.
Claims (8)
1. a kind of infantile heat-clearing and antitussive ball, characterized in that be mixed by Chinese medicine material and refined honey；The Chinese medicine material, by weight
Measure number meter, including 85-95 parts of Chinese ephedra, 70-80 parts of frying semen armeniacae amarae, 160-200 parts of gypsum, 43-47 parts of Radix Glycyrrhizae, frying purple perilla
85-95 parts sub-, 85-95 parts of lepidium seed, 43-47 parts of frying radish seed, 70-80 parts of Cynanchum glaucescens, 70-80 parts of arisaema cum bile, wine process radix scutellariae
43-47 parts, 140-160 parts of jujube；Modified starch is added in the refined honey.
2. infantile heat-clearing and antitussive ball according to claim 1, characterized in that the mass ratio of the Chinese medicine material and refined honey is
1:0.6-0.7。
3. infantile heat-clearing and antitussive ball according to claim 1, characterized in that the mass ratio of the refined honey and modified starch is
5:2。
4. infantile heat-clearing and antitussive ball according to claim 1, characterized in that 90 parts of Chinese ephedra, 75 parts of frying semen armeniacae amarae, gypsum
180 parts, 45 parts of Radix Glycyrrhizae, 90 parts of frying perilla seed, 90 parts of lepidium seed, 45 parts of frying radish seed, 75 parts of Cynanchum glaucescens, 75 parts of arisaema cum bile,
Wine processs 45 parts of radix scutellariae, 150 parts of jujube.
5. the preparation method of infantile heat-clearing and antitussive ball as described in claim 1, characterized in that include the following steps:
Chinese medicine material is prepared：Take Chinese ephedra, frying semen armeniacae amarae, gypsum, Radix Glycyrrhizae, frying perilla seed, lepidium seed, frying radish seed, white
Before, arisaema cum bile, wine toast radix scutellariae, jujube, be ground into fine powder, mixing is rear to be sieved；
Refined honey:Fresh Honey is taken, honey is heated to 116-118 DEG C, until when there is the uniformly product of faint yellow thin bubble, is stopped
Only heat；
Starch conversion：Extracting corn starch, ethyl alcohol, sodium hydroxide, water after uniform stirring, increase temperature of reaction system to 40-42
DEG C, after reacting 1.2-1.4h, monoxone is added in reaction system, after the reaction was continued later 2-2.4h, reaction system is cooled down
To room temperature, the acid-base value of reaction system is adjusted to neutrality, is washed later with 80% ethanol solution, after dry, crush；
It is prepared by infantile heat-clearing and antitussive ball：Modified starch, refined honey are taken, under conditions of pressure is 30MPa, inlet air temperature is 170 DEG C,
Under conditions of leaving air temp is 65 DEG C, is dried, Chinese medicine material be added later, after mixing, pill, it is dry to get.
6. the preparation method of infantile heat-clearing and antitussive ball according to claim 5, characterized in that mistake after Chinese medicine material grinding
60-90 mesh sieves.
7. the preparation method of infantile heat-clearing and antitussive ball according to claim 5, characterized in that the starch conversion step
In, cornstarch, ethyl alcohol, sodium hydroxide, water, chloroacetic mass ratio are 100:56:23:300:26.
8. the preparation method of infantile heat-clearing and antitussive ball according to claim 5, characterized in that the starch conversion step
In, after completion of the reaction, adjust the pH to 7-7.2 of reaction system.
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| JP5686452B2 (en) * | 2013-03-01 | 2015-03-18 | 塩野義製薬株式会社 | Tablets containing irbesartan |
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