CN115531324A - Ginseng and poria cocos granules with high forming rate, low hygroscopicity and good fluidity and capable of strengthening spleen and stomach - Google Patents
Ginseng and poria cocos granules with high forming rate, low hygroscopicity and good fluidity and capable of strengthening spleen and stomach Download PDFInfo
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- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 5
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Classifications
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/06—Fungi, e.g. yeasts
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
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- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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Abstract
The invention discloses a ginseng-poria spleen and stomach strengthening granule with high molding rate, low hygroscopicity and good fluidity and a preparation method thereof. The ginseng-poria spleen and stomach strengthening granule with high molding rate, low hygroscopicity and good fluidity is composed of raw materials and auxiliary materials, wherein the raw materials comprise, by weight, 100 to 200 parts of radix glehniae, 90 to 150 parts of poria cocos, 100 to 200 parts of bighead atractylodes rhizome, 90 to 150 parts of fried Chinese yam, 90 to 150 parts of fried hyacinth bean, 90 to 150 parts of lotus seed, 50 to 90 parts of stir-baked fructus amomi with salt, 50 to 90 parts of dried orange peel, 50 to 90 parts of fried semen coicis and 50 to 90 parts of liquorice, and the auxiliary material is lactose. The preparation method comprises the steps of pretreatment, extraction and post-treatment. The preparation process is stable and reliable, the conditions are reasonable and feasible, the reproducibility is good, the molding rate of the prepared particles is high, the hygroscopicity is low, and the fluidity is good.
Description
Technical Field
The invention belongs to the technical field of medicines, and particularly relates to a ginseng and poria cocos spleen and stomach strengthening granule with high forming rate, low hygroscopicity and good fluidity and a preparation method thereof.
Background
At present, from the production angle of most granules, the compressibility and the adhesive effect of sucrose as an auxiliary material are relatively good, most of conventional auxiliary materials in the granules are selected from sucrose, and the ginseng and poria cocos granules with the functions of invigorating spleen and stomach, promoting diuresis and relieving diarrhea are mainly used for tonifying spleen and invigorating stomach, and are used for treating weakness of spleen and stomach, indigestion, diarrhea or vomiting, emaciation and color atrophy, and mental fatigue and weakness.
Disclosure of Invention
The invention considers the problem of patient compliance, considers the problems of forming rate, hygroscopicity and the like of the Shenling spleen and stomach strengthening granules, deeply researches and analyzes the auxiliary materials of the Shenling spleen and stomach strengthening granules, develops a preparation process which has stable process, reasonable and feasible production conditions, high forming rate, low hygroscopicity and good fluidity and is used for preparing the Shenling spleen and stomach strengthening granules, and simultaneously expands the applicable population of the Shenling spleen and stomach strengthening granules, in particular expands the population of diabetes patients.
The invention aims to provide the ginseng-poria cocos granules with high molding rate, low hygroscopicity and good fluidity for strengthening the spleen and stomach;
the invention aims to realize that the Shenling spleen and stomach strengthening granules with high molding rate, low hygroscopicity and good fluidity are composed of raw materials and auxiliary materials, wherein the raw materials comprise 100 to 200 parts by weight of radix glehniae, 90 to 150 parts by weight of tuckahoe, 100 to 200 parts by weight of bighead atractylodes rhizome, 90 to 150 parts by weight of stir-fried Chinese yam, 90 to 150 parts by weight of stir-fried hyacinth bean, 90 to 150 parts by weight of lotus seed, 50 to 90 parts by weight of stir-fried fructus amomi with salt, 50 to 90 parts by weight of dried orange peel, 50 to 90 parts by weight of stir-fried semen coicis and 50 to 90 parts by weight of liquorice, the auxiliary materials are lactose, and the preparation method comprises the steps of pretreatment, extraction and post-treatment, and specifically comprises the following steps:
A. pretreatment: mixing and crushing the raw materials of coix seeds and Chinese yams in a formula ratio, and sieving the mixture with a 80-mesh sieve to obtain a material a;
B. extraction:
1) Adding an ethanol solution with the volume percentage concentration of 50-70% and the mass of 2-3 times of that of fructus amomi into the raw material fructus amomi in the formula ratio, and distilling and extracting to obtain fructus amomi volatile oil b and medicine residues c;
2) Recovering ethanol from the residue c, decocting with radix Glehniae, poria, atractylodis rhizoma, parched semen lablab album, semen Nelumbinis, pericarpium Citri Tangerinae and Glycyrrhrizae radix in water, and filtering to obtain medicinal liquid d and residue e;
C. and (3) post-treatment:
1) Concentrating the liquid medicine d to obtain an extract g;
3) Uniformly mixing the material a, the fructus amomi volatile oil b, the extract g and auxiliary materials, and then granulating to obtain the ginseng and poria cocos spleen and stomach strengthening granules with high target object forming rate, low hygroscopicity and good fluidity;
the mass ratio of the material a, the fructus amomi volatile oil b, the extract g and auxiliary materials lactose is 1: (0.2 to 0.3) 1: (1.3 to 1.6).
The mass ratio of the material a to the fructus amomi volatile oil b to the extract g to the auxiliary material lactose is 1:0.25:1: (1.3 to 1.5).
The material a, the fructus amomi volatile oil b, the extract g and the auxiliary material lactose are in the following mass ratio: 1:0.25:1:1.4.
The invention adopts the formula proportion of the lactose as the specific auxiliary material and the specific lactose, and realizes the specific technical scheme of high molding rate of the prepared particles, low hygroscopicity and good fluidity; meanwhile, the preparation process of the invention is stable and reliable, the conditions are reasonable and feasible, and the reproducibility is good.
Detailed Description
The present invention is further illustrated by the following examples, which are not intended to be limiting in any way, and any modifications or alterations based on the teachings of the present invention are intended to fall within the scope of the present invention.
The ginseng-poria spleen and stomach strengthening granules with high molding rate, low hygroscopicity and good fluidity comprise raw materials and auxiliary materials, wherein the raw materials comprise, by weight, 100 to 200 parts of radix glehniae, 90 to 150 parts of poria cocos, 100 to 200 parts of bighead atractylodes rhizome, 90 to 150 parts of fried Chinese yam, 90 to 150 parts of fried hyacinth bean, 90 to 150 parts of lotus seed, 50 to 90 parts of fructus amomi stir-baked with salt, 50 to 90 parts of dried orange peel, 50 to 90 parts of fried semen coicis and 50 to 90 parts of liquorice, and the auxiliary materials are lactose, and the preparation method comprises the steps of pretreatment, extraction and post-treatment, and specifically comprises the following steps:
A. pretreatment: mixing and crushing the raw materials of coix seeds and Chinese yams in a formula ratio, and sieving the mixture with a 80-mesh sieve to obtain a material a;
B. extraction:
1) Adding an ethanol solution with the volume percentage concentration of 50 to 70 percent and the mass of 2 to 3 times that of the amomum villosum into a raw material amomum villosum in a formula ratio, and distilling and extracting to obtain an amomum villosum volatile oil b and dregs c;
2) Recovering ethanol from the residue c, decocting with radix Glehniae, poria, atractylodis rhizoma, parched semen lablab album, semen Nelumbinis, pericarpium Citri Tangerinae and Glycyrrhrizae radix in water, and filtering to obtain medicinal liquid d and residue e;
C. and (3) post-treatment:
1) Concentrating the liquid medicine d to obtain an extract g;
3) Uniformly mixing the material a, the fructus amomi volatile oil b, the extract g and auxiliary materials, and then granulating to obtain the ginseng tuckahoe spleen and stomach strengthening granules with high target object forming rate, low hygroscopicity and good fluidity;
the mass ratio of the material a to the fructus amomi volatile oil to the extract g to the auxiliary material lactose is 1: (0.2 to 0.3) 1: (1.3 to 1.6).
The raw materials comprise, by weight, 100 to 150 parts of radix glehniae, 90 to 120 parts of poria cocos, 100 to 150 parts of bighead atractylodes rhizome, 90 to 120 parts of fried Chinese yam, 90 to 120 parts of fried hyacinth bean, 90 to 120 parts of lotus seed, 70 to 90 parts of stir-baked fructus amomi with salt, 70 to 90 parts of dried orange peel, 70 to 90 parts of fried semen coicis and 70 to 90 parts of liquorice.
The raw materials comprise, by weight, 130.5 parts of radix glehniae, 108.5 parts of poria cocos, 144.4 parts of bighead atractylodes rhizome, 108.5 parts of fried Chinese yam, 108.5 parts of fried hyacinth bean, 108.5 parts of lotus seed, 72.8 parts of fructus amomi preparata, 72.8 parts of dried orange peel, 72.8 parts of fried coix seed and 72.8 parts of liquorice.
The raw materials comprise, by weight, 150 to 200 parts of radix glehniae, 120 to 150 parts of poria cocos, 150 to 200 parts of bighead atractylodes rhizome, 120 to 150 parts of fried Chinese yam, 120 to 150 parts of fried hyacinth bean, 120 to 150 parts of lotus seed, 50 to 70 parts of stir-baked fructus amomi with salt, 50 to 70 parts of dried orange peel, 50 to 70 parts of fried coix seed and 50 to 70 parts of liquorice.
The raw materials comprise, by weight, 158.5 parts of radix glehniae, 126.5 parts of poria cocos, 158.5 parts of bighead atractylodes rhizome, 126.5 parts of fried Chinese yam, 126.5 parts of fried hyacinth bean, 126.5 parts of lotus seed, 63.6 parts of stir-fried fructus amomi with salt, 63.6 parts of dried orange peel, 63.6 parts of fried semen coicis and 63.6 parts of liquorice.
The auxiliary material also comprises a flavoring agent.
The flavoring agent is aspartame.
The adding amount of the flavoring agent is 0.5 to 1 percent of the total mass of the granules.
The adding amount of the flavoring agent is 0.66 percent of the total mass of the granules.
The invention is further illustrated by the following specific examples:
example 1
The invention relates to a molding process research of Shenling spleen and stomach strengthening granules with high molding rate, low hygroscopicity and good fluidity:
1. standard prescription
130.5g of radix glehniae, 108.5g of tuckahoe, 108.5g of bighead atractylodes rhizome, 144.4g of Chinese yam (fried), 108.5g of hyacinth bean (fried), 108.5g of lotus seed, 108.5g of fructus amomi (stir-fried with salt), 72.8g of dried orange peel, 72.8g of coix seed (fried), 72.8g of liquorice and 72.8g.
2. Research on Molding Process
2.1 grinding
Mixing Coicis semen and rhizoma Dioscoreae, pulverizing into fine powder, sieving with 80 mesh sieve, and mixing;
fine powder of medicinal materials =181g ± 3%.
2.2 extraction
Oil extraction: distilling fructus Amomi with 2 times (145.6 g) of 60% ethanol to extract volatile oil, collecting volatile oil, recovering ethanol from residue, and keeping residue.
Boiling in water: decocting the rest 7 materials in water for 1.5 hr, adding fructus Amomi residue, and decocting for 1 hr for 2 times. Adding water: 3 to 4 times of the medicinal materials for the first time, 2 to 3 times of the medicinal materials for the second time, and 1.5 to 2.5 times of the medicinal materials for the third time, and filtering the liquid medicine for later use.
2.3 concentration
The filtrates are combined and concentrated (50-80 ℃) to obtain extractum with the relative density of 1.30-1.34 g/ml (room temperature).
2.4 screening of Single adjuvants
Wet granulation is adopted, and dextrin, lactose, soluble starch and dextrin are selected: lactose (1: soluble starch (1: soluble starch (1). The moldability, hygroscopicity, and flowability of the extract after granulation were used as indicators for examination. The type of adjuvant used in the granules was selected based on the composite score. The results are shown in Table 2.
Measurement of Molding Rate: the particle size and particle size distribution were measured by 0982 (second double screening method) according to the general rules of the Chinese pharmacopoeia (fourth pharmacopoeia) 2020 edition. Granules that could pass through sieve No. 1 and could not pass through sieve No. 5 were defined as acceptable granules, and the molding ratio (%) = (acceptable granule weight)/total weight of granules × 100%.
Determination of moisture absorption rate: the desiccator with NaCl supersaturated solution at the bottom was incubated in a constant temperature incubator at 20 ℃ for 48 hours to reach 75% RH. And (3) putting a certain amount of particle samples into a weighing bottle dried to constant weight, uniformly spreading the particle samples to the thickness of about 2mm, precisely weighing the particle samples, putting the particle samples into a dryer with the relative humidity of 75%, opening a weighing bottle cap, weighing the particle samples after 48 hours, and calculating the moisture absorption rate. Moisture absorption (%) = (weight after particulate moisture absorption-original weight before particulate moisture absorption)/original weight before particulate moisture absorption × 100%.
Determination of flowability: the angle of repose (alpha) of particles is measured by adopting a fixed funnel method, 3 funnels are placed in series and fixed on an iron support, the height of the funnels from coordinate paper on a horizontal desktop is enabled to be appropriate, the height of the lower mouth end of the lowest funnel from the coordinate paper is h, sample particles are slowly poured into the funnel along the wall of the uppermost funnel until the particles on the coordinate paper are piled up and touch the lower mouth end of the lowest funnel, the radius r of the bottom of the cone is measured, and the alpha calculation formula is (tg alpha = h/r).
And (3) comprehensive scoring: the weight coefficient of each index was defined as a molding ratio of 0.4, a moisture absorption rate of 0.3, a fluidity of 0.3, and a composite score (%) = [ (particle size/maximum particle size) × 0.4+ (minimum moisture absorption rate/moisture absorption rate) × 0.3+ (minimum angle of repose/angle of repose) × 0.3].
TABLE 1 compatibility prescription of different adjuvants and principal drugs
TABLE 2 compatibility of different adjuvants and principal drugs, hygroscopicity, moldability, fluidity and comprehensive score
And (4) analyzing results: the results in table 2 show that dextrin is used as an auxiliary material, so that the moisture absorption rate is high, and the prepared particles are hard and have poor taste; the lactose has excellent properties in all aspects, and has good dissolving property and compression resistance, and the prepared granules have good quality, high first-pass percent and high comprehensive score by taking the lactose as an auxiliary material; soluble starch, lactose: dextrin (1), dextrin: starch (1: starch (1. Therefore, in order to keep better physicochemical properties of the granules, lactose is selected as an auxiliary material to prepare the granules.
2.5 orthogonal test optimized preparation forming process
On the basis of single auxiliary material investigation, the influence of different feeding proportions of the auxiliary materials on the hygroscopicity, the formability and the flowability of the granules is further investigated, and a more proper auxiliary material proportion is selected for the granule forming. The use amount of the auxiliary materials is selected as a factor A (the ratio of the extract to the fine powder to the auxiliary materials), the volume fraction of the wetting agent ethanol is selected as a factor B, the use amount of the wetting agent is selected as a factor C (the ratio of the extract to the ethanol) to serve as an investigation index, and the experimental level is designed according to different factors. See table 3.
TABLE 3 orthogonal test design factor horizon
TABLE 4 orthogonal test design Table and results
TABLE 5 analysis of variance results
Note: f 0.05 （2，2）=19。
According to the analysis result of the orthogonal test, the optimal process is A 2 B 3 C 1 And (3) obtaining an extract: fine powder: the dosage ratio of the auxiliary materials is 1.
2.6 proportion and amount of adjuvants and extract
According to the analysis result of the orthogonal test, the adding amount of the lactose as the auxiliary material has significant influence on the comprehensive score of the granules, so under the condition, a single-factor test is adopted, the hygroscopicity, the formability and the angle of repose of the granules are taken as indexes, the influence of different proportions of the lactose and the extract on the indexes is further considered, and further optimization is carried out.
2.6.1 selection of amount of adjuvant
Taking 5 parts of ginseng and poria cocos spleen and stomach strengthening granular medicinal material fine powder, fructus amomi volatile oil and extract respectively, uniformly mixing the medicinal material fine powder, the fructus amomi volatile oil and the extract with different amounts of auxiliary materials (lactose) according to the specified amount in the following table 6, granulating and drying to obtain the traditional Chinese medicine.
TABLE 6 compatibility prescription of adjuvants and extracts in different proportions
And (3) investigating each index: the ratio of lactose to extract is selected according to the operability, properties, hygroscopicity, moldability and angle of repose during granulation of the granules, and the hygroscopicity, moldability and angle of repose are used as indicators to comprehensively evaluate, preferably the optimum ratio, wherein the comprehensive indicator = (40/maximum molding ratio) × molding ratio + (minimum angle of repose × 30)/angle of repose + (minimum angle of moisture absorption × 30)/moisture absorption rate.
2.6.2 measurement of moldability
The particle formability was measured according to the experimental procedure and the formability score was calculated using the formula: (40/maximum molding ratio). Times.molding ratio, the results are shown in Table 7. As is clear from Table 7, formulation 3 is the most excellent in moldability.
TABLE 7 measurement of moldability
2.6.3 determination of the angle of repose
The angle of repose of the particles was determined according to the experimental procedure and 3 times and the average was calculated. The angle of repose score calculation uses the formula: (minimum angle of repose. Times.30)/angle of repose, the results are shown in Table 8. As is clear from Table 8, the flowability of formula 4 is the best.
TABLE 8 determination of angle of repose
2.6.4 determination of hygroscopicity
The hygroscopicity of the granules was measured according to the experimental procedure, and 2 groups were made in total, and the average value was calculated. The moisture absorption rate value is calculated by the following formula: (minimum moisture absorption rate. Times.30)/moisture absorption rate, the results are shown in Table 9. As can be seen from Table 9, formula 5 has the lowest moisture absorption rate and is not easily affected by moisture.
TABLE 9 determination of hygroscopicity
2.6.5 description of the traits
TABLE 10 description of the properties
2.6.6 composite score
The results of the three tests on the moldability, moisture absorption rate and angle of repose were evaluated in combination and are shown in Table 11.
TABLE 11 composite score
According to the comprehensive score of the data in the table, the comprehensive score of the prescription 3 (namely the ratio of lactose to extract is 1.4. However, the comprehensive score of the prescription 4 (i.e. the ratio of lactose to extract is 1.5) is 95.90, which reaches 97.84% of the prescription 3, but the optimal ratio is selected from lactose: extract (1.4.
3. Best process verification test
In order to verify the reproducibility and feasibility of the preferred ginseng and poria cocos spleen and stomach strengthening particle forming process, repeated tests are carried out for 3 times according to the preferred process, and as a verification test, the process is found to be stable and reliable, the conditions are reasonable and feasible, the reproducibility is good, the forming rate of the prepared particles is high, the hygroscopicity is low, and the flowability is good. The results of the validation experiment are shown in Table 12.
TABLE 12 results of 3 validation tests
Determination of a flavoring agent: the prescription uses lactose as an auxiliary material, the prepared granules have poor taste, and a certain amount of flavoring agent is added for improving the compliance and the compliance of patients to the medicine. The aspartame is added into the materials, and people with different tastes are used for testing, so that when the addition of the aspartame is increased to 0.66%, the purpose of taste correction is achieved, and meanwhile, the applicable population can be increased, and the aspartame can be popularized and used in diabetes patients.
4. Comparison of samples with lactose and sucrose as adjuvants
Respectively taking lactose and sucrose as auxiliary materials to prepare 3 batches of ginseng and poria cocos spleen and stomach strengthening particle samples, and detecting and comparing the samples. The experimental result shows that compared with the original common auxiliary material sucrose of the Shenling spleen and stomach strengthening granules, the sample prepared by taking the optimized lactose as the auxiliary material has good forming rate, hygroscopicity and fluidity and higher comprehensive score, is a more ideal auxiliary material and can ensure that the preparation quality is more stable. The data are shown in Table 13.
TABLE 13 detection and comparison data of Shenling spleen and stomach strengthening granule sample
Claims (9)
1. The Shenling spleen and stomach strengthening granules with high molding rate, low hygroscopicity and good fluidity are characterized by comprising raw materials and auxiliary materials, wherein the raw materials comprise 100 to 200 parts by weight of radix glehniae, 90 to 150 parts by weight of poria cocos, 100 to 200 parts by weight of bighead atractylodes rhizome, 90 to 150 parts by weight of fried Chinese yam, 90 to 150 parts by weight of stir-fried hyacinth bean, 90 to 150 parts by weight of lotus seed, 50 to 90 parts by weight of stir-fried fructus amomi with salt, 50 to 90 parts by weight of dried orange peel, 50 to 90 parts by weight of stir-fried semen coicis and 50 to 90 parts by weight of liquorice, the auxiliary materials are lactose, and the preparation method comprises the steps of pretreatment, extraction and post-treatment, and specifically comprises the following steps:
A. pretreatment: mixing, crushing and sieving raw materials of coix seeds and Chinese yams in a formula ratio by a sieve of 80 meshes to obtain a material a;
B. extraction:
1) Adding an ethanol solution with the volume percentage concentration of 50-70% and the mass of 2-3 times of that of fructus amomi into the raw material fructus amomi in the formula ratio, and distilling and extracting to obtain fructus amomi volatile oil b and medicine residues c;
2) Recovering ethanol from the residue c, and decocting radix Glehniae, poria, atractylodis rhizoma, parched semen lablab album, semen Nelumbinis, pericarpium Citri Tangerinae and Glycyrrhrizae radix in water, filtering to obtain medicinal liquid d and residue e;
C. and (3) post-treatment:
1) Concentrating the liquid medicine d to obtain an extract g;
3) Uniformly mixing the material a, the fructus amomi volatile oil b, the extract g and auxiliary materials, and then granulating to obtain the ginseng tuckahoe spleen and stomach strengthening granules with high target object forming rate, low hygroscopicity and good fluidity;
the mass ratio of the material a to the fructus amomi volatile oil b to the extract g to the auxiliary material lactose is 1: (0.2 to 0.3) 1: (1.3 to 1.6).
2. The Shenling spleen and stomach invigorating granule with high molding rate, low hygroscopicity and good fluidity as claimed in claim 1, wherein the raw materials comprise, by weight, 100 to 150 parts of radix glehniae, 90 to 120 parts of Poria cocos, 100 to 150 parts of Atractylodes macrocephala, 90 to 120 parts of fried Chinese yam, 90 to 120 parts of fried hyacinth bean, 90 to 120 parts of lotus seed, 70 to 90 parts of stir-baked fructus Amomi with salt, 70 to 90 parts of dried orange peel, 70 to 90 parts of fried coix seed and 70 to 90 parts of licorice.
3. The Shenling spleen and stomach invigorating granule as claimed in claim 2, wherein the raw materials comprise (by weight parts) radix Glehniae 130.5, poria 108.5, atractylodis rhizoma 144.4, rhizoma Dioscoreae 108.5, semen lablab album 108.5, semen Nelumbinis 108.5, fructus Amomi (processed with salt) 72.8, pericarpium Citri Tangerinae 72.8, coicis semen 72.8, and Glycyrrhrizae radix 72.8.
4. The Shenling spleen and stomach invigorating granule with high forming rate, low hygroscopicity and good fluidity according to claim 1, which is characterized in that the raw materials comprise, by weight, 150 to 200 parts of radix glehniae, 120 to 150 parts of Poria cocos, 150 to 200 parts of rhizoma Atractylodis Macrocephalae, 120 to 150 parts of fried Chinese yam, 120 to 150 parts of fried hyacinth bean, 120 to 150 parts of lotus seed, 50 to 70 parts of stir-baked fructus Amomi with salt, 50 to 70 parts of dried orange peel, 50 to 70 parts of fried semen coicis and 50 to 70 parts of liquorice.
5. The Shenling spleen and stomach invigorating granule as claimed in claim 4, wherein the raw materials include (by weight parts) radix Glehniae 158.5 parts, poria 126.5 parts, atractylodis rhizoma 158.5 parts, rhizoma Dioscoreae 126.5 parts, semen lablab album 126.5 parts, semen Nelumbinis 126.5 parts, fructus Amomi (processed with salt) 63.6 parts, pericarpium Citri Tangerinae 63.6 parts, coicis semen 63.6 parts, and Glycyrrhrizae radix 63.6 parts.
6. The Shenling spleen-stomach strengthening granule with high molding rate, low hygroscopicity and good fluidity as claimed in claim 1, wherein the adjuvant further comprises a flavoring agent.
7. The Shenling spleen and stomach invigorating granule with high molding rate, low hygroscopicity and good fluidity as claimed in claim 1, wherein the flavoring agent is aspartame.
8. The Shenling spleen and stomach strengthening granule with high forming rate, low hygroscopicity and good fluidity according to claim 6 or 7, wherein the addition amount of the flavoring agent is 0.5 to 1 percent of the total mass of the granule.
9. The Shenling spleen-stomach strengthening granule with high forming rate, low hygroscopicity and good fluidity as claimed in claim 8, wherein the addition amount of the flavoring agent is 0.66% of the total mass of the granule.
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