CN106420986A - Traditional Chinese medicine granules for treating postinfectious cough and CVA (cough variant asthma), preparation method and application - Google Patents
Traditional Chinese medicine granules for treating postinfectious cough and CVA (cough variant asthma), preparation method and application Download PDFInfo
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Abstract
The invention discloses traditional Chinese medicine granules for treating postinfectious cough and CVA (cough variant asthma) as well as a preparation method and an application of the traditional Chinese medicine granules. The traditional Chinese medicine granules comprise effective medicine components and pharmaceutically proper pharmaceutical excipients, wherein the traditional Chinese medicine raw materials for preparing the effective medicine components comprise 1-12 parts by weight of mix-fried ephedra, 1-12 parts by weight of perilla leaf, 1-12 parts by weight of earthworm, 1-12 parts by weight of prepared loquat leaf, 1-8 parts by weight of perilla fruit, 1-10 parts by weight of cicada slough, 1-10 parts by weight of hogfennel root, 1-12 parts by weight of great burdock achene and 1-10 parts by weight of Chinese magnoliavine fruit; the pharmaceutically proper pharmaceutical excipients comprise beta-cyclodextrin, mannitol, sodium carboxymethyl starch and dextrin.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation and preparation method thereof is and in particular to one kind treats postinfectious cough and cough becomes
The Chinese medicine granules of different in nature asthma and preparation method
Background technology
Cough variant asthma (Cough variant asthma, CVA), also known as concealment type asthma or cough variant asthma, is
A kind of specific type of asthma.Its particularity be that it almost do not have any pant or dyspnea symptom, therefore often leaked
Examine, mistaken diagnosis, wrong treatment, many patients, by prolonged and repeated ineffectually application antibiotic and antitussive medicine, lead to protracted inflammation to increase.Closely
Nian Lai, progressively intensification CVA being recognized with people, Chinese medicine achieves good effect in terms for the treatment of CVA.Pass in the traditional Chinese medical science
In system book, there is no the name of disease completely not corresponding with CVA.Ancient medicine, can only be whole from macroscopic view due to being limited by prevailing condition
The angle understanding cause of disease of body, not yet to divide difference CVA from many cough symptoms is an independent disease.This disease is mainly faced
Bed shows as dry cough, few expectorant, itching throat, notably may occur in which uncomfortable in chest, asthma etc.；And primary disease has a chronic delay again, obstinate refractory and
The features such as recurrent exerbation.From the shown clinical signs characteristic analysis of the generation of this disease, development it is believed that CVA is when belonging to the traditional Chinese medical science
" wind is coughed " category.
CN1605349A discloses a kind of Chinese medicine composition treating postinfectious cough and cough variant asthma and its system
Preparation Method.But active compound thing does not have the record of process for producing granula.Granule is compared dustability, tack, gathers with powder
Collection property, hygroscopicity are all less, are conducive to divided dose；It had both maintained decoction and had acted on rapid advantage, overcame interim decoction again
Trouble and easily mould evil idea go bad shortcoming；Granule can dissolve or is suspended in water, is conducive to medicine to absorb in vivo, maintains
The rapid-action feature of liquid preparation, but compared with liquid preparation stable in properties, be easy to take, carry, store；Be suitably added aromatic,
Correctivess, coloring agent etc., can be made into the various pharmaceutical preparation of color, patient is happy to take, particularly suitable to children.
Content of the invention
It is an object of the invention to provide a kind of granule treating postinfectious cough and cough variant asthma, it includes
Effective ingredient and pharmaceutically suitable pharmaceutic adjuvant, the raw material of Chinese medicine preparing described effective ingredient is：
Herba Ephedrae (processed), Folium Perillae, Pheretima, Folium Eriobotryae (processed), Fructus Perillae, Periostracum Cicadae, Radix Peucedani, Fructus Arctii and Fructus Schisandrae Chinensis；
Pharmaceutically suitable pharmaceutic adjuvant includes betacyclodextrin, Mannitol, carboxymethylstach sodium, dextrin.
A kind of granule treating postinfectious cough and cough variant asthma of the present invention, it is effective that it includes medicine
Composition and pharmaceutically suitable pharmaceutic adjuvant, the raw material of Chinese medicine preparing described effective ingredient is：
Herba Ephedrae (processed) 1-12 weight portion, Folium Perillae 1-12 weight portion, Pheretima 1-12 weight portion, Folium Eriobotryae (processed) 1-12 weight portion,
Fructus Perillae 1-8 weight portion, Periostracum Cicadae 1-10 weight portion, Radix Peucedani 1-10 weight portion, Fructus Arctii 1-12 weight portion and Fructus Schisandrae Chinensis 1-10 weight
Part；
Pharmaceutically suitable pharmaceutic adjuvant includes betacyclodextrin, Mannitol, carboxymethylstach sodium, dextrin.
Wherein, the consumption of pharmaceutically suitable pharmaceutic adjuvant can be betacyclodextrin 0.05-0.3 weight portion, Mannitol
0.5-3 weight portion, carboxymethylstach sodium 1-5 weight portion, appropriate dextrin.
A kind of granule treating postinfectious cough and cough variant asthma of the present invention, it is effective that it includes medicine
Composition and pharmaceutically suitable pharmaceutic adjuvant, the raw material of Chinese medicine preparing described effective ingredient is：
Herba Ephedrae (processed) 4-6 weight portion, Folium Perillae 4-6 weight portion, Pheretima 4-6 weight portion, Folium Eriobotryae (processed) 4-6 weight portion, Fructus Perillae
2-4 weight portion, Periostracum Cicadae 3-5 weight portion, Radix Peucedani 3-5 weight portion, Fructus Arctii 4-6 weight portion and Fructus Schisandrae Chinensis 3-5 weight portion；
Pharmaceutically suitable pharmaceutic adjuvant includes betacyclodextrin 0.05-0.3 weight portion, Mannitol 0.5-3 weight portion, carboxylic
First Starch Sodium 1-5 weight portion, appropriate dextrin.
Treatment postinfectious cough of the present invention and the granule of cough variant asthma, pharmaceutic adjuvant also includes Flos Chrysanthemi
Plain 0.05-1 weight portion.
Treatment postinfectious cough of the present invention and granule, effective ingredient and the pharmacy of cough variant asthma
Above suitable pharmaceutic adjuvant is：
The present invention also aims to providing a kind of system of the granule treating postinfectious cough and cough variant asthma
Preparation Method, it includes：
Folium Perillae, Radix Peucedani are soaked, and extract volatile oil, collect volatile oil, add water and betacyclodextrin, grind, and do
Dry, it is ground into fine powder, make volatile oil betacyclodextrin clathrate, standby；The another device of aqueous solution after distillation is collected standby；
The five tastes such as Fructus Arctii (parched) and Pheretima, Periostracum Cicadae, sweet Folium Eriobotryae, Fructus Perillae (parched) add water to cook, filtration, filtrate with above-mentioned
Aqueous extract after distillation merges, and is concentrated into thick paste, cold preservation, filtration, decompression filtrate recycling ethanol, and concentrates as thick paste, standby；
Fructus Schisandrae Chinensis and Herba Ephedrae add alcohol heating reflux and extract, filtration, and merging filtrate stands overnight, centrifuging and taking supernatant,
Add Mannitol concentrating under reduced pressure, add 1/6 carboxymethylstach sodium and water extract-alcohol precipitation concentrated solution, be evaporated to thick paste, add remaining
5/6 carboxymethylstach sodium be uniformly mixed, drying under reduced pressure, dry cream pulverize sieve for subsequent use；
Take above-mentioned dried cream powder, volatile oil betacyclodextrin clathrate and appropriate dextrin mix homogeneously, pelletized with appropriate amount of ethanol,
It is dried, pelletize, obtain final product.
The preparation method of the granule for the treatment of postinfectious cough of the present invention and cough variant asthma, it includes：
Folium Perillae, Radix Peucedani are soaked, and extract volatile oil, collect volatile oil, add water and betacyclodextrin, grind, and do
Dry, it is ground into fine powder, make volatile oil betacyclodextrin clathrate, standby；The another device of aqueous solution after distillation is collected standby；
The five tastes such as Fructus Arctii (parched) and Pheretima, Periostracum Cicadae, sweet Folium Eriobotryae, Fructus Perillae (parched) add water to cook, filtration, filtrate with above-mentioned
Aqueous extract after distillation merges, and is concentrated into thick paste, cold preservation, filtration, decompression filtrate recycling ethanol, and concentrates as thick paste, standby；
Fructus Schisandrae Chinensis and Herba Ephedrae add alcohol heating reflux and extract, filtration, and merging filtrate stands overnight, centrifuging and taking supernatant,
Add Mannitol concentrating under reduced pressure, add 1/6 carboxymethylstach sodium and water extract-alcohol precipitation concentrated solution, be evaporated to thick paste, add remaining
5/6 carboxymethylstach sodium be uniformly mixed, drying under reduced pressure, dry cream pulverize sieve for subsequent use；
Take above-mentioned dried cream powder, volatile oil betacyclodextrin clathrate, steviosin and appropriate dextrin mix homogeneously, fitted with ethanol
Amount is pelletized, and is dried, and pelletizes, obtains final product.
The preparation method of the granule for the treatment of postinfectious cough of the present invention and cough variant asthma, it includes：
Folium Perillae, Radix Peucedani add 5-12 times of water and soak 0.5-3 hour, extract volatile oil 5-10 hour, collect volatile oil, add
2-6 times amount water and 4-12 times amount betacyclodextrin, grind, dry, pulverize into fine powder, make volatile oil betacyclodextrin inclusion
Thing, standby；The another device of aqueous solution after distillation is collected standby；
The five tastes such as Fructus Arctii (parched) and Pheretima, Periostracum Cicadae, sweet Folium Eriobotryae, Fructus Perillae (parched) add water to cook 1-3 time, every time plus 5-15
Times amount decocts 0.5-2 hour, filtration, and filtrate is merged with the aqueous extract after above-mentioned distillation, concentrate (vacuum≤- 0.07MPa,
Temperature≤70 DEG C) to relative density for 1.09-1.11 (60 DEG C) thick paste, plus ethanol makes alcohol content reach 70%, cold preservation 24 hours,
Filter, decompression filtrate recycling ethanol (vacuum≤0.05-0.07MPa, temperature≤70 DEG C), and be concentrated into relative density and be
The thick paste of 1.16-1.18 (50 DEG C), standby；
Fructus Schisandrae Chinensis and Herba Ephedrae add 80% ethanol, are heated to reflux 1-3 time, add 5-10 times amount every time and extract 1-3 hour, filter,
Merging filtrate, stands overnight, centrifuging and taking supernatant, adds Mannitol concentrating under reduced pressure (vacuum≤- 0.07MPa, temperature≤70
DEG C) it is 1.05-1.06 (60 DEG C survey) to relative density, add 1/6 carboxymethylstach sodium and water extract-alcohol precipitation concentrated solution, concentrating under reduced pressure
(vacuum≤- 0.04MPa, temperature≤75 DEG C) are the thick paste of 1.20-1.25 (60 DEG C) to relative density, add remaining 5/6
Carboxymethylstach sodium is uniformly mixed, drying under reduced pressure (vacuum≤- 0.04MPa, temperature≤75 DEG C), and dry cream pulverized 100 mesh
Sieve, standby；
Take above-mentioned dried cream powder, volatile oil betacyclodextrin clathrate, steviosin and appropriate dextrin mix homogeneously, use 95% second
Alcohol is pelletized in right amount, is dried, and pelletizes, obtains final product.
The preparation method of the granule for the treatment of postinfectious cough of the present invention and cough variant asthma, it includes：
Folium Perillae, Radix Peucedani add 9 times of water and soak 1 hour, extract volatile oil 8 hours, collect volatile oil, add 4 times amount water and 8
Times amount betacyclodextrin, grinds, less than 40 DEG C dry, pulverize into fine powder, make volatile oil betacyclodextrin clathrate, standby；
The another device of aqueous solution after distillation is collected standby；
The five tastes such as Fructus Arctii (parched) and Pheretima, Periostracum Cicadae, sweet Folium Eriobotryae, Fructus Perillae (parched) add water to cook three times, add 10 times for the first time
Amount decocts 1 hour, second plus 8 times amount decoct 1 hour, third time plus 8 times amount decoct 1 hour, filtration, filtrate and above-mentioned distillation
Aqueous extract afterwards merges, and concentrating (vacuum≤- 0.07MPa, temperature≤70 DEG C) to relative density is 1.09-1.11 (60 DEG C)
Thick paste, plus ethanol makes alcohol content reach 70%, cold preservation 24 hours, filtration, decompression filtrate recycling ethanol (vacuum≤0.05-
0.07MPa, temperature≤70 DEG C), and it is concentrated into the thick paste that relative density is 1.16-1.18 (50 DEG C), standby；
Fructus Schisandrae Chinensis and Herba Ephedrae add 80% ethanol, are heated to reflux three times, add 8 times amount for the first time and extract 1.5 hours, second
Plus 6 times amount extract 1.5 hours, third time plus 6 times amount extract 1.5 hours, filtration, merging filtrate, stand overnight, centrifuging and taking supernatant
Liquid, adds Mannitol concentrating under reduced pressure (vacuum≤- 0.07MPa, temperature≤70 DEG C) to relative density to be (60 DEG C of 1.05-1.06
Survey), add 1/6 carboxymethylstach sodium and water extract-alcohol precipitation concentrated solution, concentrating under reduced pressure (vacuum≤- 0.04MPa, temperature≤75 DEG C) is extremely
Relative density is the thick paste of 1.20-1.25 (60 DEG C), adds remaining 5/6 carboxymethylstach sodium to be uniformly mixed, drying under reduced pressure
(vacuum≤- 0.04MPa, temperature≤75 DEG C), dry cream pulverized 100 mesh sieves, standby；
Take above-mentioned dried cream powder, volatile oil betacyclodextrin clathrate, steviosin and appropriate dextrin mix homogeneously, use 95% second
Alcohol is pelletized in right amount, is dried, and pelletizes, obtains final product.
The present invention also aims to providing a kind of prepared treatment postinfectious cough of preparation method as described above and coughing
Cough the granule of variant asthma.
Present invention also offers the granule of described treatment postinfectious cough and cough variant asthma is in preparation treatment
Application in postinfectious cough and cough variant asthma medicine.
Specific embodiment
Embodiment 1
(1) medicine material
(2) pharmaceutic adjuvant
Betacyclodextrin 0.144g Mannitol 1.26g carboxymethylstach sodium 2.70g
Steviosin 0.18g dextrin is appropriate (about 1.836g)
(3) preparation method
Folium Perillae, Radix Peucedani add 9 times of water and soak 1 hour, extract volatile oil 8 hours, collect volatile oil, add 4 times amount water and 8
Times amount betacyclodextrin, grinds, less than 40 DEG C dry, pulverize into fine powder, make volatile oil betacyclodextrin clathrate, standby.
The another device of aqueous solution after distillation is collected standby.
The five tastes such as Fructus Arctii (parched) and Pheretima, Periostracum Cicadae, sweet Folium Eriobotryae, Fructus Perillae (parched) add water to cook three times, add 10 times for the first time
Amount decocts 1 hour, second plus 8 times amount decoct 1 hour, third time plus 8 times amount decoct 1 hour, filtration, filtrate and above-mentioned distillation
Aqueous extract afterwards merges, and concentrating (vacuum≤- 0.07MPa, temperature≤70 DEG C) to relative density is 1.09-1.11 (60 DEG C)
Thick paste, plus ethanol makes alcohol content reach 70%, cold preservation 24 hours, filtration, decompression filtrate recycling ethanol (vacuum≤0.05-
0.07MPa, temperature≤70 DEG C), and it is concentrated into the thick paste that relative density is 1.16-1.18 (50 DEG C), standby.
Fructus Schisandrae Chinensis and Herba Ephedrae add 80% ethanol, are heated to reflux three times, add 8 times amount for the first time and extract 1.5 hours, second
Plus 6 times amount extract 1.5 hours, third time plus 6 times amount extract 1.5 hours, filtration, merging filtrate, stand overnight, centrifuging and taking supernatant
Liquid, adds Mannitol concentrating under reduced pressure (vacuum≤- 0.07MPa, temperature≤70 DEG C) to relative density to be (60 DEG C of 1.05-1.06
Survey), add 1/6 carboxymethylstach sodium and water extract-alcohol precipitation concentrated solution, concentrating under reduced pressure (vacuum≤- 0.04MPa, temperature≤75 DEG C) is extremely
Relative density is the thick paste of 1.20-1.25 (60 DEG C), adds remaining 5/6 carboxymethylstach sodium to be uniformly mixed, drying under reduced pressure
(vacuum≤- 0.04MPa, temperature≤75 DEG C), dry cream pulverized 100 mesh sieves, standby.
Take above-mentioned dried cream powder, volatile oil betacyclodextrin clathrate, steviosin and appropriate dextrin mix homogeneously, use 95% second
Alcohol is pelletized in right amount, is dried, and pelletizes, makes 1000g, obtain final product.
Embodiment 2
(1) medicine material
(2) pharmaceutic adjuvant
Betacyclodextrin 0.176g Mannitol 0.98 carboxymethylstach sodium 2.91g
Steviosin 0.19g dextrin is appropriate (about 1.836g)
(3) preparation method
Folium Perillae, Radix Peucedani add 5 times of water and soak 0.5 hour, extract volatile oil 5 hours, collect volatile oil, add 2 times amount water
With 4 times amount betacyclodextrins, grind, less than 40 DEG C dry, pulverize into fine powder, make volatile oil betacyclodextrin clathrate, standby
With.The another device of aqueous solution after distillation is collected standby.
The five tastes such as Fructus Arctii (parched) and Pheretima, Periostracum Cicadae, sweet Folium Eriobotryae, Fructus Perillae (parched) add water to cook three times, add 8 times for the first time
Amount decocts 1 hour, second plus 5 times amount decoct 1 hour, third time plus 5 times amount decoct 1 hour, filtration, filtrate and above-mentioned distillation
Aqueous extract afterwards merges, and concentrating (vacuum≤- 0.07MPa, temperature≤70 DEG C) to relative density is 1.09-1.11 (60 DEG C)
Thick paste, plus ethanol makes alcohol content reach 70%, cold preservation 24 hours, filtration, decompression filtrate recycling ethanol (vacuum≤0.05-
0.07MPa, temperature≤70 DEG C), and it is concentrated into the thick paste that relative density is 1.16-1.18 (50 DEG C), standby.
Fructus Schisandrae Chinensis and Herba Ephedrae add 80% ethanol, are heated to reflux three times, add 10 times amount for the first time and extract 3 hours, add for second
5 times amount are extracted 2 hours, and third time plus 6 times amount are extracted 2 hours, filtration, and merging filtrate stands overnight, centrifuging and taking supernatant, plus
Entering Mannitol concentrating under reduced pressure (vacuum≤- 0.07MPa, temperature≤70 DEG C) to relative density is 1.05-1.06 (60 DEG C of surveys), plus
Enter 1/6 carboxymethylstach sodium and water extract-alcohol precipitation concentrated solution, concentrating under reduced pressure (vacuum≤- 0.04MPa, temperature≤75 DEG C) is to relatively close
Spend the thick paste for 1.20-1.25 (60 DEG C), add remaining 5/6 carboxymethylstach sodium to be uniformly mixed, drying under reduced pressure (vacuum
≤ -0.04MPa, temperature≤75 DEG C), dry cream pulverized 100 mesh sieves, standby.
Take above-mentioned dried cream powder, volatile oil betacyclodextrin clathrate, steviosin and appropriate dextrin mix homogeneously, use 95% second
Alcohol is pelletized in right amount, is dried, and pelletizes, makes 1000g, obtain final product.
Embodiment 3
(1) medicine material
(2) pharmaceutic adjuvant
Betacyclodextrin 0.112g Mannitol 1.54g carboxymethylstach sodium 2.70g
Steviosin 0.18g dextrin is appropriate (about 1.836g)
(3) preparation method
Folium Perillae, Radix Peucedani add 12 times of water and soak 1 hour, extract volatile oil 10 hours, collect volatile oil, add 6 times amount water
With 12 times amount betacyclodextrins, grind, less than 40 DEG C dry, pulverize into fine powder, make volatile oil betacyclodextrin clathrate, standby
With.The another device of aqueous solution after distillation is collected standby.
The five tastes such as Fructus Arctii (parched) and Pheretima, Periostracum Cicadae, sweet Folium Eriobotryae, Fructus Perillae (parched) add water to cook three times, add 10 times for the first time
Amount decocts 1 hour, second plus 8 times amount decoct 1 hour, third time plus 8 times amount decoct 1 hour, filtration, filtrate and above-mentioned distillation
Aqueous extract afterwards merges, and concentrating (vacuum≤- 0.07MPa, temperature≤70 DEG C) to relative density is 1.09-1.11 (60 DEG C)
Thick paste, plus ethanol makes alcohol content reach 70%, cold preservation 24 hours, filtration, decompression filtrate recycling ethanol (vacuum≤0.05-
0.07MPa, temperature≤70 DEG C), and it is concentrated into the thick paste that relative density is 1.16-1.18 (50 DEG C), standby.
Fructus Schisandrae Chinensis and Herba Ephedrae add 80% ethanol, are heated to reflux three times, add 10 times amount for the first time and extract 3 hours, add for second
6 times amount are extracted 2 hours, and third time plus 6 times amount are extracted 2 hours, filtration, and merging filtrate stands overnight, centrifuging and taking supernatant, plus
Entering Mannitol concentrating under reduced pressure (vacuum≤- 0.07MPa, temperature≤70 DEG C) to relative density is 1.05-1.06 (60 DEG C of surveys), plus
Enter 1/6 carboxymethylstach sodium and water extract-alcohol precipitation concentrated solution, concentrating under reduced pressure (vacuum≤- 0.04MPa, temperature≤75 DEG C) is to relatively close
Spend the thick paste for 1.20-1.25 (60 DEG C), add remaining 5/6 carboxymethylstach sodium to be uniformly mixed, drying under reduced pressure (vacuum
≤ -0.04MPa, temperature≤75 DEG C), dry cream pulverized 100 mesh sieves, standby.
Take above-mentioned dried cream powder, volatile oil betacyclodextrin clathrate, steviosin and appropriate dextrin mix homogeneously, use 95% second
Alcohol is pelletized in right amount, is dried, and pelletizes, makes 1000g, obtain final product.
Embodiment 4
(1) medicine material
(2) pharmaceutic adjuvant
Betacyclodextrin 0.176g Mannitol 1.4g carboxymethylstach sodium 3.31g
Steviosin 0.22g dextrin is appropriate (about 1.836g)
(3) preparation method
Folium Perillae, Radix Peucedani add 9 times of water and soak 1 hour, extract volatile oil 8 hours, collect volatile oil, add 4 times amount water and 8
Times amount betacyclodextrin, grinds, less than 40 DEG C dry, pulverize into fine powder, make volatile oil betacyclodextrin clathrate, standby.
The another device of aqueous solution after distillation is collected standby.
The five tastes such as Fructus Arctii (parched) and Pheretima, Periostracum Cicadae, sweet Folium Eriobotryae, Fructus Perillae (parched) add water to cook three times, add 10 times for the first time
Amount decocts 1 hour, second plus 8 times amount decoct 1 hour, third time plus 8 times amount decoct 1 hour, filtration, filtrate and above-mentioned distillation
Aqueous extract afterwards merges, and concentrating (vacuum≤- 0.07MPa, temperature≤70 DEG C) to relative density is 1.09-1.11 (60 DEG C)
Thick paste, plus ethanol makes alcohol content reach 70%, cold preservation 24 hours, filtration, decompression filtrate recycling ethanol (vacuum≤0.05-
0.07MPa, temperature≤70 DEG C), and it is concentrated into the thick paste that relative density is 1.16-1.18 (50 DEG C), standby.
Fructus Schisandrae Chinensis and Herba Ephedrae add 80% ethanol, are heated to reflux three times, add 8 times amount for the first time and extract 1.5 hours, second
Plus 6 times amount extract 1.5 hours, third time plus 6 times amount extract 1.5 hours, filtration, merging filtrate, stand overnight, centrifuging and taking supernatant
Liquid, adds Mannitol concentrating under reduced pressure (vacuum≤- 0.07MPa, temperature≤70 DEG C) to relative density to be (60 DEG C of 1.05-1.06
Survey), add 1/6 carboxymethylstach sodium and water extract-alcohol precipitation concentrated solution, concentrating under reduced pressure (vacuum≤- 0.04MPa, temperature≤75 DEG C) is extremely
Relative density is the thick paste of 1.20-1.25 (60 DEG C), adds remaining 5/6 carboxymethylstach sodium to be uniformly mixed, drying under reduced pressure
(vacuum≤- 0.04MPa, temperature≤75 DEG C), dry cream pulverized 100 mesh sieves, standby.
Take above-mentioned dried cream powder, volatile oil betacyclodextrin clathrate, steviosin and appropriate dextrin mix homogeneously, use 95% second
Alcohol is pelletized in right amount, is dried, and pelletizes, makes 1000g, obtain final product.
Embodiment 5
(1) medicine material
(2) pharmaceutic adjuvant
Betacyclodextrin 0.346g Mannitol 2.8g carboxymethylstach sodium 6.48g
Steviosin 0.43g dextrin is appropriate (about 4.406g)
(3) preparation method
Folium Perillae, Radix Peucedani add 9 times of water and soak 1 hour, extract volatile oil 8 hours, collect volatile oil, add 4 times amount water and 8
Times amount betacyclodextrin, grinds, less than 40 DEG C dry, pulverize into fine powder, make volatile oil betacyclodextrin clathrate, standby.
The another device of aqueous solution after distillation is collected standby.
The five tastes such as Fructus Arctii (parched) and Pheretima, Periostracum Cicadae, sweet Folium Eriobotryae, Fructus Perillae (parched) add water to cook three times, add 10 times for the first time
Amount decocts 1 hour, second plus 8 times amount decoct 1 hour, third time plus 8 times amount decoct 1 hour, filtration, filtrate and above-mentioned distillation
Aqueous extract afterwards merges, and concentrating (vacuum≤- 0.07MPa, temperature≤70 DEG C) to relative density is 1.09-1.11 (60 DEG C)
Thick paste, plus ethanol makes alcohol content reach 70%, cold preservation 24 hours, filtration, decompression filtrate recycling ethanol (vacuum≤0.05-
0.07MPa, temperature≤70 DEG C), and it is concentrated into the thick paste that relative density is 1.16-1.18 (50 DEG C), standby.
Fructus Schisandrae Chinensis and Herba Ephedrae add 80% ethanol, are heated to reflux three times, add 8 times amount for the first time and extract 1.5 hours, second
Plus 6 times amount extract 1.5 hours, third time plus 6 times amount extract 1.5 hours, filtration, merging filtrate, stand overnight, centrifuging and taking supernatant
Liquid, adds Mannitol concentrating under reduced pressure (vacuum≤- 0.07MPa, temperature≤70 DEG C) to relative density to be (60 DEG C of 1.05-1.06
Survey), add 1/6 carboxymethylstach sodium and water extract-alcohol precipitation concentrated solution, concentrating under reduced pressure (vacuum≤- 0.04MPa, temperature≤75 DEG C) is extremely
Relative density is the thick paste of 1.20-1.25 (60 DEG C), adds remaining 5/6 carboxymethylstach sodium to be uniformly mixed, drying under reduced pressure
(vacuum≤- 0.04MPa, temperature≤75 DEG C), dry cream pulverized 100 mesh sieves, standby.
Take above-mentioned dried cream powder, volatile oil betacyclodextrin clathrate, steviosin and appropriate dextrin mix homogeneously, use 95% second
Alcohol is pelletized in right amount, is dried, and pelletizes, makes 1000g, obtain final product.
Experiment comparative example
1. increase the screening test of centrifugation step
In embodiment 1 prescription ratio and extraction process, prepare Herba Ephedrae, schisandrol extract, with 80 mesh sieve net filtrations, filtrate
Slightly cloudy；There is a small amount of precipitation, shaking postprecipitation dispersibles after standing overnight.With slightly cloudy extracting solution concentrating under reduced pressure, it is also easy to produce
Precipitation, affects granule melting.Centrifugation precipitate, microexamination, find that there is cell structure, show to contain in alcohol extract
There is a small amount of fine medicinal material powder, 80 eye mesh screens can be passed through, removal can be centrifuged.
Take Herba Ephedrae 50g, Fructus Schisandrae Chinensis 40g, prepare alcohol extract about 1440ml by embodiment 1 methods described, with 80 eye mesh screen mistakes
Filter, filtrate is divided into two parts.A copy of it is centrifuged (4000 turns/min, 5min), collects precipitation with distilled water flushing centrifuge tube,
Drying under reduced pressure, mensure precipitation capacity is medical material amount 0.27%, accounts for the 2.96% of extract amount.Take detached supernatant and be not centrifuged
Alcohol extract respectively be evaporated to appearance precipitation, measure the volume of concentrate.Result is as follows：
The impact that in table 1 alcohol extract, contained fine medicinal material powder produces to precipitation in concentration process
Result shows, alcohol extract is mixed with the fine medicinal material powder that can pass through extraction pot bottom sieve net (80 mesh), is medical material amount 0.27%,
Account for the 2.96% of extract amount, amount is less, can cause precipitation in concentration process.Centrifugation can remove fine medicinal material powder, and can slow down
In concentration process, precipitation produces.Determine that Herba Ephedrae, schisandrol extract concentrate, stand overnight, centrifugation supernatant, standby.
2. Herba Ephedrae, the screening test of schisandrol extract adjuvant
Take Herba Ephedrae 105g, Fructus Schisandrae Chinensis 84g to prepare alcohol extract by embodiment 1 method, filter, filtrate centrifugation (4000 turns/min,
5min), take detached supernatant to be divided into 7 parts (being equivalent to medical material 27g), every part of about 480ml, be separately added into different auxiliary material 2.7g
(consumption is the 10% of medical material amount), concentrating under reduced pressure (vacuum≤- 0.07MPa, temperature≤70 DEG C) precipitates to appearance, to occur sinking
The minimum index of volume formed sediment, screens supplementary product kind.Result is as follows：
Variety classes adjuvant is added to stop the investigation that precipitation produces in table 2 concentration process
Result shows, maltose alcohol and Mannitol are dissolved in ethanol solution, all can stop and produce precipitation in concentration process.Because of wheat
Bud sugar alcohol no pharmaceutic adjuvant standard, determines and selects Mannitol.
3. the investigation of Mannitol consumption
Take Herba Ephedrae 75g, Fructus Schisandrae Chinensis 60g to prepare alcohol extract by embodiment 1 methods described, filter, filtrate centrifugation (4000 turns/
Min, 5min), take detached supernatant to be divided into 5 parts (being equivalent to medical material 27g), every part of about 480ml, be separately added into different amounts
Mannitol, concentrating under reduced pressure (vacuum≤- 0.07MPa, temperature≤70 DEG C) to occur precipitation, with occur precipitate volume minimum
Index, determines Mannitol consumption.Result is as follows：
The investigation of Mannitol consumption is added in table 3 concentration process
Result shows, to be concentrated into the minimum volume occurring without precipitation as index, determines that Mannitol consumption is medical material amount
14%, extracting solution is concentrated into 2 times of medical material amount.
4. the investigation of adjuvant when alcohol extracting concentrate, water extract-alcohol precipitation concentrated solution merge concentration
Take Folium Perillae 45g, Radix Peucedani 36g, Pheretima 45g, sweet Folium Eriobotryae 45g, Fructus Perillae (parched) 27g, Periostracum Cicadae 36g, Fructus Arctii (parched)
45g (common 279g), preparation method as described in embodiment 1, extract volatile oil, water extract-alcohol precipitation, concentrating under reduced pressure (vacuum≤-
0.07MPa, temperature≤70 DEG C) to 0.8 times of medical material amount, it is divided into 3 parts (every part of 75ml is equivalent to medical material 93g) respectively, standby
With.
Take Herba Ephedrae 45g, Fructus Schisandrae Chinensis 36g by previous process parameter, alcohol extraction, filtrate is centrifuged (4000 turns/min, 5min), takes point
From supernatant add Mannitol 11.34g (the 14% of medical material amount) be evaporated to 2 times of medical material amounts, be divided into 3 parts (every part
54ml, is equivalent to medical material 27g), standby.
Merge alcohol extracting concentrate, water extract-alcohol precipitation concentrated solution (every part of 129ml is equivalent to medical material 120g), be separately added into difference
Species adjuvant 1.2g (1% medical material amount), concentrating under reduced pressure (vacuum≤- 0.04MPa, temperature≤75 DEG C) precipitates to appearance, to go out
The minimum index of volume now precipitating, screens supplementary product kind.Result is as follows：
Variety classes adjuvant is added to stop the investigation that precipitation produces in the low concentrated solution of table 4 amount of alcohol
Result shows, reduces with the volume of concentrate, and determining alcohol reduces, and maltodextrin and carboxymethylstach sodium all dissolve, all
Can stop and in concentration process, produce precipitation.The aqueous solution that carboxymethylstach sodium is formed is sticky, stops the effect that precipitation produces from being better than wheat
Bud dextrin, the minimum index of volume precipitating, determines that carboxymethylstach sodium selected by adjuvant.
5. in concentration process, add the investigation of carboxymethylstach sodium consumption
By embodiment 1 methods described preparation alcohol extracting concentrate, water extract-alcohol precipitation concentrated solution, (every part of 129ml, is equivalent to for merging
Medical material 120g), it is separately added into the carboxymethylstach sodium of different amounts, concentrating under reduced pressure (vacuum≤- 0.04MPa, temperature≤75 DEG C)
To precipitation occurs, measure the volume that precipitation occurs.Result is as follows：
The investigation of carboxymethylstach sodium consumption is added in table 5 concentration process
Result shows, to be concentrated into the minimum volume occurring without precipitation as index, determines that carboxymethylstach sodium consumption is medical material
Amount 1.125%, can be concentrated into 0.7 times of medical material amount, and mensure relative density is 1.20-1.23 (60 DEG C), and concentrated solution is substantially not
Containing ethanol, can be dried safely.
6. concentrated solution drying process is investigated
Homogeneous when above-mentioned concentration liquid temp is high, no precipitate；After cooling, produce bulky grain precipitation；Heating postprecipitation can not be molten
Solution.Carboxymethylstach sodium is dissolved in water, can form thick gel.Intend adding in concentrated solution and adopt carboxymethylstach sodium, it is to avoid concentrated solution
Precipitation is produced after cooling.
Prepare alcohol extracting concentrate, water extract-alcohol precipitation concentrated solution as stated above respectively, (every part of 129ml, is equivalent to medical material for merging
120g), it is separately added into the carboxymethylstach sodium of medical material amount 1.125%, concentrating under reduced pressure (vacuum≤- 0.04MPa, temperature≤75 DEG C)
To being concentrated into 0.7 times of medical material amount, mensure relative density is 1.20-1.23 (60 DEG C), and the carboxylic first being separately added into different proportion is formed sediment
Powder sodium, is stirred to dissolve, mix homogeneously, cooling, places 24 hours, drying under reduced pressure (vacuum≤- 0.04MPa, temperature≤75
DEG C), the phenomenon during seeing drying, dry cream pulverized 100 mesh sieves, checked melting.Result is as follows：
The investigation of carboxymethylstach sodium consumption is added in table 6 dry run
Result shows：Dry run adds 5.625% carboxymethylstach sodium of medical material amount (for adding carboxylic first to form sediment in concentration process
5 times of powder sodium), do not produce precipitation after cooling, dried cream powder melting is qualified.Drying under reduced pressure process is rapider, and dry cream is difficult moisture absorption,
Matter is crisp to pass through 100 mesh sieves it is easy to pulverize.
7. concentration, the checking of drying process
With Herba Ephedrae alkaloid content and granule melting as index, concentration technology is investigated.
As stated above, extracted, precipitate with ethanol, concentration, drying, dry cream (being equivalent to medical material 200g) is extracted in preparation, pulverizes
100 mesh sieves, measure Herba Ephedrae alkaloid content, paste volume and melting, and result is as follows.
Table 7 concentrated solution drying process is investigated
By aforementioned Study on extraction result, Herba Ephedrae, schisandra chinensis medicinal material 45g, alcohol extracting thing 4.5g (paste-forming rate about 10%)；
Fructus Arctii etc. 7 taste medical material 155g, water extract-alcohol precipitation extract 9.9g (paste-forming rate about 6.4%)；Add adjuvant Mannitol 6.3g, carboxylic first
Starch Sodium 13.5g, total 19.8g；Extract amounts to and should be 34.2g.Actual extract powder 34.06g, shows to extract paste volume
Substantially it is consistent.
By aforementioned Study on extraction result, the rate of transform of ethanol extraction ephedrine and pseudoephedrine sum is about 71%,
After concentrated, dry, the rate of transform is 64.2%, shows that concentration, dry run epheday intermedia alkaloid are volatilized with vapor less.
The melting of extract powder is qualified, can be made into granule.
8. the mensure of extract powder moisture absorption rate
This product extract is placed in temperature and is 25 DEG C, in the environment of relative humidity is 58%, through different time continuous precision
Weigh,
Measure this product extract powder hygroscopic capacity in such circumstances.It is shown in Table 8.
The mensure (relative humidity 58%) of table 8 moisture absorption rate
Result shows, the environment that this product is 58% in relative humidity is placed 24 hours, and the hygroscopic capacity of extract is 2.10%.
The result of above-mentioned critical relative humidity and moisture absorption rate shows, this product extract powder is difficult moisture absorption, produces ring in GMP
Preparation can be completed under border produce.
9. the investigation of granulating process parameter
Granulating process adopts extract dried cream powder and volatile oil clathrate compound, adds granule to commonly use adjuvant (dextrin) and in right amount
Correctivess (steviosin) mix homogeneously, using wet granulation, adds ethanol in proper amount, through pelletizing, is dried, granulate and obtain.
The investigation of 9.1 correctivess (steviosin) consumption
By embodiment 1 method, prepare extract dried cream powder 2.65g and volatile oil clathrate compound 0.046g and (be equivalent to medical material
13.3g), not commensurability steviosin is added to mix, heating water 200ml stirring and dissolving, with taste as index, determine steviosin consumption,
Result is as follows.
The investigation of table 9 steviosin consumption
| Steviosin consumption (g) | Taste |
| 0.04 | Bitter |
| 0.06 | Sweeter, taste is soft |
| 0.08 | Cross sweet |
Determine that steviosin consumption is 0.06g, be equivalent to the 0.45% of medical material weight.
The determination of 9.2 dextrin consumptions
This product daily Herba Ephedrae, schisandra chinensis medicinal material 9g, alcohol extracting thing 0.9g (paste-forming rate 10%)；Fructus Arctii etc. 7 taste medicine
Material 31g, water extract-alcohol precipitation extract 1.98g (paste-forming rate about 6.4%)；Volatile oil clathrate compound about 0.144g；Mannitol 1.26g；Carboxylic
First Starch Sodium 2.7g；Stevioside 0.18g；Amount to 7.164g, design granule specification is accordingly：Add appropriate amount of auxiliary materials dextrin to 9g
(3g/ bag, daily 3 times), about plus dextrin 1.836g.Daily amount 9g, wherein extract 3.024g, adjuvant 5.796g,
Adjuvant is about 2 times of extract.
The investigation of 9.3 granulating process concentration of alcohol
Take extract powder, volatile oil clathrate compound, steviosin, dextrin mix homogeneously in embodiment 1 prescription ratio, add appropriate
Alcohol granulation, with the character of granule, granularity, melting as index, is investigated with the concentration of ethanol, consumption to granulation, result
As follows
Table 10 granulating process parameter is investigated
Determine that, with 95% alcohol granulation, consumption is about the 10%. of mixed powder
9.4 mobility of particles are investigated
The angle of repose measuring granule is 27 °, shows that mobility of particle is good.
Claims (10)
1. a kind of granule treating postinfectious cough and cough variant asthma it is characterised in that include effective ingredient and
Pharmaceutically suitable pharmaceutic adjuvant, the raw material of Chinese medicine preparing described effective ingredient is：
Herba Ephedrae (processed) 1-12 weight portion, Folium Perillae 1-12 weight portion, Pheretima 1-12 weight portion, Folium Eriobotryae (processed) 1-12 weight portion, Fructus Perillae
1-8 weight portion, Periostracum Cicadae 1-10 weight portion, Radix Peucedani 1-10 weight portion, Fructus Arctii 1-12 weight portion and Fructus Schisandrae Chinensis 1-10 weight portion；Medicine
On, suitable pharmaceutic adjuvant includes betacyclodextrin, Mannitol, carboxymethylstach sodium, dextrin.
2. a kind of granule treating postinfectious cough and cough variant asthma it is characterised in that include effective ingredient and
Pharmaceutically suitable pharmaceutic adjuvant, the raw material of Chinese medicine preparing described effective ingredient is：
Herba Ephedrae (processed) 4-6 weight portion, Folium Perillae 4-6 weight portion, Pheretima 4-6 weight portion, Folium Eriobotryae (processed) 4-6 weight portion, Fructus Perillae 2-4 weight
Amount part, Periostracum Cicadae 3-5 weight portion, Radix Peucedani 3-5 weight portion, Fructus Arctii 4-6 weight portion and Fructus Schisandrae Chinensis 3-5 weight portion；
Pharmaceutically suitable pharmaceutic adjuvant includes betacyclodextrin 0.05-0.3 weight portion, Mannitol 0.5-3 weight portion, carboxylic first shallow lake
Powder sodium 1-5 weight portion, appropriate dextrin.
3. the granule for the treatment of postinfectious cough as claimed in claim 2 and cough variant asthma is it is characterised in that medicinal
Adjuvant also includes steviosin 0.05-1 weight portion.
4. the granule for the treatment of postinfectious cough as claimed in claim 3 and cough variant asthma is it is characterised in that medicine
The raw material of Chinese medicine of effective ingredient and pharmaceutically suitable pharmaceutic adjuvant are：
5. the preparation side of the granule of the treatment postinfectious cough as described in any one of claim 1-2 and cough variant asthma
Method, its feature includes：
Folium Perillae, Radix Peucedani are soaked, and extract volatile oil, collect volatile oil, add water and betacyclodextrin, grind, and are dried, powder
It is broken into fine powder, make volatile oil betacyclodextrin clathrate, standby；The another device of aqueous solution after distillation is collected standby；
Fructus Arctii (parched) is added water to cook with five tastes such as Pheretima, Periostracum Cicadae, sweet Folium Eriobotryae, Fructus Perillae (parched), filtration, filtrate and above-mentioned distillation
Rear aqueous extract merges, and is concentrated into thick paste, cold preservation, filtration, decompression filtrate recycling ethanol, and concentrates as thick paste, standby；
Fructus Schisandrae Chinensis and Herba Ephedrae add alcohol heating reflux and extract, filtration, and merging filtrate stands overnight, centrifuging and taking supernatant, adds
Mannitol concentrating under reduced pressure, adds 1/6 carboxymethylstach sodium and water extract-alcohol precipitation concentrated solution, is evaporated to thick paste, adds remaining 5/6
Carboxymethylstach sodium is uniformly mixed, drying under reduced pressure, and dry cream is pulverized and sieved for subsequent use；
Take above-mentioned dried cream powder, volatile oil betacyclodextrin clathrate and appropriate dextrin mix homogeneously, pelletized with appropriate amount of ethanol, do
Dry, pelletize, obtain final product.
6. the preparation side of the granule of the treatment postinfectious cough as described in any one of claim 1-4 and cough variant asthma
Method, its feature includes：
Folium Perillae, Radix Peucedani are soaked, and extract volatile oil, collect volatile oil, add water and betacyclodextrin, grind, and are dried, powder
It is broken into fine powder, make volatile oil betacyclodextrin clathrate, standby；The another device of aqueous solution after distillation is collected standby；
Fructus Arctii (parched) is added water to cook with five tastes such as Pheretima, Periostracum Cicadae, sweet Folium Eriobotryae, Fructus Perillae (parched), filtration, filtrate and above-mentioned distillation
Rear aqueous extract merges, and is concentrated into thick paste, cold preservation, filtration, decompression filtrate recycling ethanol, and concentrates as thick paste, standby；
Fructus Schisandrae Chinensis and Herba Ephedrae add alcohol heating reflux and extract, filtration, and merging filtrate stands overnight, centrifuging and taking supernatant, adds
Mannitol concentrating under reduced pressure, adds 1/6 carboxymethylstach sodium and water extract-alcohol precipitation concentrated solution, is evaporated to thick paste, adds remaining 5/6
Carboxymethylstach sodium is uniformly mixed, drying under reduced pressure, and dry cream is pulverized and sieved for subsequent use；
Take above-mentioned dried cream powder, volatile oil betacyclodextrin clathrate, steviosin and appropriate dextrin mix homogeneously, use appropriate amount of ethanol system
Grain, is dried, and pelletizes, obtains final product.
7. the preparation method of the granule of the treatment postinfectious cough described in claim 6 and cough variant asthma, its feature
Including：
Folium Perillae, Radix Peucedani add 5-12 times of water and soak 0.5-3 hour, extract volatile oil 5-10 hour, collect volatile oil, add 2-6
Times amount water and 4-12 times amount betacyclodextrin, grind, dry, pulverize into fine powder, make volatile oil betacyclodextrin clathrate, standby
With；The another device of aqueous solution after distillation is collected standby；
The five tastes such as Fructus Arctii (parched) and Pheretima, Periostracum Cicadae, sweet Folium Eriobotryae, Fructus Perillae (parched) add water to cook 1-3 time, add 5-15 times amount every time
Decoct 0.5-2 hour, filtration, filtrate is merged with the aqueous extract after above-mentioned distillation, concentrate (vacuum≤- 0.07MPa, temperature
≤ 70 DEG C) to relative density for 1.09-1.11 (60 DEG C) thick paste, plus ethanol makes alcohol content reach 70%, cold preservation 24 hours, filter
Cross, decompression filtrate recycling ethanol (vacuum≤0.05-0.07MPa, temperature≤70 DEG C), and be concentrated into relative density for 1.16-
The thick paste of 1.18 (50 DEG C), standby；
Fructus Schisandrae Chinensis and Herba Ephedrae add 80% ethanol, are heated to reflux 1-3 time, add 5-10 times amount every time and extract 1-3 hour, filtration, merge
Filtrate, stands overnight, centrifuging and taking supernatant, adds Mannitol concentrating under reduced pressure (vacuum≤- 0.07MPa, temperature≤70 DEG C) extremely
Relative density is 1.05-1.06 (60 DEG C of survey), adds 1/6 carboxymethylstach sodium and water extract-alcohol precipitation concentrated solution, concentrating under reduced pressure (vacuum
≤ -0.04MPa, temperature≤75 DEG C) it is the thick paste of 1.20-1.25 (60 DEG C) to relative density, add remaining 5/6 carboxymethylstarch
Sodium is uniformly mixed, drying under reduced pressure (vacuum≤- 0.04MPa, temperature≤75 DEG C), and dry cream pulverized 100 mesh sieves, standby；
Take above-mentioned dried cream powder, volatile oil betacyclodextrin clathrate, steviosin and appropriate dextrin mix homogeneously, fitted with 95% ethanol
Amount is pelletized, and is dried, and pelletizes, obtains final product.
8. the preparation method of the granule for the treatment of postinfectious cough as claimed in claim 7 and cough variant asthma, it is special
Levy including：
Folium Perillae, Radix Peucedani add 9 times of water and soak 1 hour, extract volatile oil 8 hours, collect volatile oil, add 4 times amount water and 8 times amount
Betacyclodextrin, grinds, less than 40 DEG C dry, pulverize into fine powder, make volatile oil betacyclodextrin clathrate, standby；Distillation
The another device of aqueous solution afterwards is collected standby；
The five tastes such as Fructus Arctii (parched) and Pheretima, Periostracum Cicadae, sweet Folium Eriobotryae, Fructus Perillae (parched) add water to cook three times, add 10 times amount for the first time and decoct
Boil 1 hour, add 8 times amount decoction 1 hour for second, third time plus 8 times amount decoct 1 hour, filter, after filtrate and above-mentioned distillation
Aqueous extract merges, and concentrates (vacuum≤- 0.07MPa, temperature≤70 DEG C) thick for 1.09-1.11 (60 DEG C) to relative density
Cream, plus ethanol makes alcohol content reach 70%, cold preservation 24 hours, filtration, decompression filtrate recycling ethanol (vacuum≤0.05-
0.07MPa, temperature≤70 DEG C), and it is concentrated into the thick paste that relative density is 1.16-1.18 (50 DEG C), standby；
Fructus Schisandrae Chinensis and Herba Ephedrae add 80% ethanol, are heated to reflux three times, add 8 times amount for the first time and extract 1.5 hours, second plus 6 times
Amount is extracted 1.5 hours, and third time plus 6 times amount are extracted 1.5 hours, filtration, and merging filtrate stands overnight, centrifuging and taking supernatant, plus
Entering Mannitol concentrating under reduced pressure (vacuum≤- 0.07MPa, temperature≤70 DEG C) to relative density is 1.05-1.06 (60 DEG C of surveys), plus
Enter 1/6 carboxymethylstach sodium and water extract-alcohol precipitation concentrated solution, concentrating under reduced pressure (vacuum≤- 0.04MPa, temperature≤75 DEG C) is to relatively close
Spend the thick paste for 1.20-1.25 (60 DEG C), add remaining 5/6 carboxymethylstach sodium to be uniformly mixed, drying under reduced pressure (vacuum
≤ -0.04MPa, temperature≤75 DEG C), dry cream pulverized 100 mesh sieves, standby；
Take above-mentioned dried cream powder, volatile oil betacyclodextrin clathrate, steviosin and appropriate dextrin mix homogeneously, fitted with 95% ethanol
Amount is pelletized, and is dried, and pelletizes, obtains final product.
9. any one of claim 5-8 preparation method is obtained treatment postinfectious cough and the granule of cough variant asthma.
10. the granule of the treatment postinfectious cough described in any one of claim 1-4 and cough variant asthma is controlled in preparation
Treat the application in postinfectious cough and cough variant asthma medicine.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2016105501284 | 2016-07-14 | ||
| CN201610550128 | 2016-07-14 |
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| Publication Number | Publication Date |
|---|---|
| CN106420986A true CN106420986A (en) | 2017-02-22 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109576715A (en) * | 2018-12-29 | 2019-04-05 | 福建金源泉科技发展有限公司 | Anti-mildew stainless steel cleaning compositions |
| CN111157633A (en) * | 2018-11-07 | 2020-05-15 | 中日友好医院 | Detection method of traditional Chinese medicine composition preparation |
| CN114224849A (en) * | 2022-01-26 | 2022-03-25 | 北京东方运嘉科技发展有限公司 | Suhuang cough relieving granules for children and preparation method thereof |
| CN114984105A (en) * | 2022-07-11 | 2022-09-02 | 深圳九华华源药业有限公司 | Traditional Chinese medicine composition for treating cough variant asthma and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1605349A (en) * | 2003-10-08 | 2005-04-13 | 晁恩祥 | Chinese traditional medicine for treating cough and variable asthma after cold and its preparation |
| CN104435294A (en) * | 2014-10-16 | 2015-03-25 | 北京东方运嘉科技发展有限公司 | Traditional Chinese medicine for treating respiratory viral infection and pharmaceutical application thereof |
-
2016
- 2016-10-21 CN CN201610916653.3A patent/CN106420986A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1605349A (en) * | 2003-10-08 | 2005-04-13 | 晁恩祥 | Chinese traditional medicine for treating cough and variable asthma after cold and its preparation |
| CN104435294A (en) * | 2014-10-16 | 2015-03-25 | 北京东方运嘉科技发展有限公司 | Traditional Chinese medicine for treating respiratory viral infection and pharmaceutical application thereof |
Non-Patent Citations (1)
| Title |
|---|
| 杨明: "《中药药剂学》", 31 July 2016, 中国中医药出版社 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111157633A (en) * | 2018-11-07 | 2020-05-15 | 中日友好医院 | Detection method of traditional Chinese medicine composition preparation |
| CN109576715A (en) * | 2018-12-29 | 2019-04-05 | 福建金源泉科技发展有限公司 | Anti-mildew stainless steel cleaning compositions |
| CN114224849A (en) * | 2022-01-26 | 2022-03-25 | 北京东方运嘉科技发展有限公司 | Suhuang cough relieving granules for children and preparation method thereof |
| CN116270821A (en) * | 2022-01-26 | 2023-06-23 | 北京东方运嘉科技发展有限公司 | Perilla Huang Zhihai granule and preparation method and quality standard thereof |
| CN114984105A (en) * | 2022-07-11 | 2022-09-02 | 深圳九华华源药业有限公司 | Traditional Chinese medicine composition for treating cough variant asthma and preparation method thereof |
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