CN108272646A - A kind of antibacterial toothpaste and preparation method thereof of hydroxyl apatite - Google Patents
A kind of antibacterial toothpaste and preparation method thereof of hydroxyl apatite Download PDFInfo
- Publication number
- CN108272646A CN108272646A CN201810318714.5A CN201810318714A CN108272646A CN 108272646 A CN108272646 A CN 108272646A CN 201810318714 A CN201810318714 A CN 201810318714A CN 108272646 A CN108272646 A CN 108272646A
- Authority
- CN
- China
- Prior art keywords
- parts
- hydroxyl apatite
- hydroxyapatite
- antibacterial toothpaste
- borax
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/413—Nanosized, i.e. having sizes below 100 nm
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
Abstract
A kind of antibacterial toothpaste of hydroxyl apatite includes mainly 35~60 parts of abrasive, 20~33 parts of moisturizer, 0.5~2 part of surfactant, 0.1~3 part of thickener, 0.1~0.6 part of flavoring agent, 9~15 parts of Dental Erosion nursing compositions and goes 8~28 parts of deionized water.Dental Erosion nursing compositions are made of 15~25 parts of 25 parts~40 parts of hydroxyapatite, 35 parts~40 parts of micron order magnesium powder, 5 parts~13 parts of metal fluoride, 15~20 parts of borax and Yunnan Baiyao extract, the toothpaste that the formula makes not only has effects that hemostasis, anti-caries, also has certain repair to the tooth damaged.
Description
Technical field
The present invention relates to consumer goods industries, are specifically related to a kind of antibacterial toothpaste containing hydroxyapatite.
Background technology
Tooth is with human body lifelong organ, and the defect of tooth seriously affects people’s lives quality, thus tooth
Daily nursing is just particularly important.Dental care products such as toothpaste are indispensable parts in people's life, good
Cleaning efficacy determine its market position, however people to the function of toothpaste also not only rest on it is clean on the basis of,
With whitening, prevent the toothpaste of the functions such as bleeding gums, antibacterial from also coming into being.Only cleaning is far from after right tooth damage
No more, how to repair, nurse the tooth of defect is that people break problem in the urgent need to address.
Invention content
In consideration of it, the present invention is intended to provide a kind of antibacterial toothpaste of hydroxyl apatite, the product have good tooth
It repairs, nursing function.To solve the above problems, the present invention is as follows using technical solution：A kind of antibacterial tooth of hydroxyl apatite
Cream includes mainly abrasive, moisturizer, surfactant, thickener, flavoring agent, Dental Erosion nursing compositions and deionized water.
Each component is as follows by mass fraction proportion：
35~60 parts of abrasive；
20~33 parts of moisturizer；
0.5~2 part of surfactant；
0.1~3 part of thickener；
0.1~0.6 part of flavoring agent；
9~15 parts of Dental Erosion nursing compositions；
8~30 parts of deionized water.
The abrasive is the mixing of precipitated calcium carbonate, precipitated silica, Carbon Dioxide hydrogen calcium and two aqueous carbonate hydrogen calcium
Object.
The preferred abrasive uses precipitated calcium carbonate, precipitated silica, Carbon Dioxide hydrogen calcium and two aqueous carbonate hydrogen
For the mixture of calcium as abrasive, the mass ratio of various abrasives is as follows：
30~70 parts of precipitated calcium carbonate；
5~25 parts of precipitated silica；
5~20 parts of Carbon Dioxide hydrogen calcium；
Two 10~25 parts of aqueous carbonate hydrogen calcium.
The moisturizer is the composition of one or more of glycerine, propylene glycol, butanediol.
Surfactant described further uses dodecyl sodium sulfate（SDS）With the mixture of acrylic acid polymer.
Dodecyl sodium sulfate in the preferred surfactant（SDS）Ratio with acrylic acid polymer is 3:2.
Further the thickener be hydroxyethyl cellulose, xanthans, carragheen, one kind in colloidality aluminium-magnesium silicate or
It is several, preferred colloidality aluminium-magnesium silicate here.
Flavoring agent described further can select the flavoring agent of different taste according to actual needs for improving toothpaste mouthfeel
Such as：Xylitol, peppermint oil, Aspartame, STEVIA REBAUDIANA etc..
The Dental Erosion nursing compositions are by hydroxyapatite, micron order magnesium powder, metal fluoride, borax, Yunnan Baiyao
The mixture of extract composition.
Hydroxyapatite, micron order magnesium powder, metal fluoride, borax, cloud in the preferred Dental Erosion nursing compositions
The weight ratio of southern baiyao extract is as follows：
25 parts~40 parts of hydroxyapatite；
15 parts~40 parts of micron order magnesium powder；
5 parts~15 parts of metal fluoride；
15~20 parts of borax；
10~25 parts of Yunnan Baiyao extract.
The size of micron order magnesium powder described further is between 75-150 microns.
Hydroxyapatite and micron order magnesium powder described further needs advanced pretreatment, processing mode as follows：
（1）The hydroxy apatite powder of selected mass fraction and pure magnesium powder are uniformly mixed with powder batch mixer；
（2）By mixed pressed by powder at sintering precast body under the conditions of the uniaxial pressure of 150Mpa-300Mpa；
（3）The step（2）Precast body be put into crucible, it is spare after high steam carries out disinfection；
（4）The step（3）The crucible equipped with precast body be put into high temperature sintering furnace, burnt between 1090-1250 degrees Celsius
Knot 2-4 hours；
（5）The step（4）Sintered sintered body carries out disinfection with high pressure steam, drying.
The preferred hydroxyapatite uses chemical precipitation method using a water calcium dihydrogen phosphate and hydroxide calcium salt as raw material
It prepares.
Metal fluoride described further can be used one or both of sodium fluoride, potassium fluoride, calcirm-fluoride, magnesium fluoride with
On mixture, preferred fluorinated potassium and magnesium fluoride in mass ratio 1 here:1 mixture.
The antibacterial toothpaste and preparation method thereof of hydroxyl apatite described further includes the following steps：
（1）A certain amount of hydroxyapatite and micron order magnesium powder are located in advance according to the pretreatment of 14 segment description of this specification
Reason, obtained product is uniformly mixed with abrasive, metal fluoride, borax, Yunnan Baiyao extract.
（2）A certain amount of moisturizer, surfactant, thickener, flavoring agent, deionized water are uniformly mixed, solid-state is made
Substance fully dissolves.
（3）By step（1）With step（2）Products therefrom mixes, and stirs.
（4）By step（3）Products therefrom sealing, high-temperature sterilization, cooling, encapsulation.
The advantages and positive effects of the present invention are：
(1) present invention is with chemical precipitation method easy to operate, with an inexpensive water calcium dihydrogen phosphate and hydroxide calcium salt for preceding body
Nano hydroxyapatite powder is made in body, and technique is simple, of low cost；
(2) nano hydroxyapatite powder mixing prepared by present invention micron order magnesium powder and above-mentioned chemical precipitation method, utilizes height
Sintering prepares the composite material of magnesium containing nanoscale, synthos and hydroxyapatite, low for equipment requirements, work in warm air
Process is simple；
(3) in a kind of pretreatment based on hydroxyapatite prepared by method of the present invention, due in high-temperature sintering process
In, magnesium powder gasification reacts with oxygen in air, generates the tiny nano oxidized magnesium powder of crystallite dimension, so that material is had antibacterial
Property；
(4) nano magnesia that oxidation reaction generates can inhibit hydroxyapatite crystal grain growing up under the high temperature conditions, make material
There are a large amount of micropore, the hydroxyapatite after crystal grain refinement has higher osteoinductive, thus has Dental Erosion for inside
The effect of.
Description of the drawings
Fig. 1 is the processing process of hydroxyapatite of the present invention and micron order magnesium powder.
Specific implementation mode
Embodiment one
A kind of antibacterial toothpaste of hydroxyl apatite includes following component by its parts by weight：
10.5 parts of precipitated calcium carbonate；
8.75 parts of precipitated silica；
7 parts of Carbon Dioxide hydrogen calcium；
Two 8.75 parts of aqueous carbonate hydrogen calcium；
20 parts of propylene glycol；
0.3 part of dodecyl sodium sulfate；
0.2 part of acrylic acid polymer；
3 parts of colloidality aluminium-magnesium silicate；
0.1 part of STEVIA REBAUDIANA；
6.25 parts of hydroxyapatite；
10 parts of micron order magnesium powder；
0.25 part of sodium fluoride；
0.25 part of potassium fluoride；
0.25 part of calcirm-fluoride；
0.5 part of magnesium fluoride；
3.75 parts of borax；
3.75 parts of Yunnan Baiyao extract；
16.4 parts of deionized water.
Embodiment two
A kind of antibacterial toothpaste of hydroxyl apatite includes following component by its parts by weight：
14 parts of precipitated calcium carbonate；
10 parts of precipitated silica；
6 parts of Carbon Dioxide hydrogen calcium；
Two 10 parts of aqueous carbonate hydrogen calcium；
20 parts of glycerine；
0.6 part of dodecyl sodium sulfate；
0.4 part of acrylic acid polymer；
2 parts of xanthans；
0.3 part of xylitol；
6 parts of hydroxyapatite；
7 parts of micron order magnesium powder；
0.5 part of potassium fluoride；Part；
0.5 part of magnesium fluoride；
3 parts of borax；
3 parts of Yunnan Baiyao extract；
16.7 parts of deionized water.
Embodiment three
A kind of antibacterial toothpaste of hydroxyl apatite includes following component by its parts by weight：
18 parts of precipitated calcium carbonate；
11.25 parts of precipitated silica；
4.5 parts of Carbon Dioxide hydrogen calcium；
Two 11.25 parts of aqueous carbonate hydrogen calcium；
25 parts of butanediol；
0.9 part of dodecyl sodium sulfate；
0.6 part of acrylic acid polymer；
1 part of hydroxyethyl cellulose；
0.1 part of STEVIA REBAUDIANA；
0.1 part of xylitol；
0.3 part of peppermint oil；
0.1 part of Aspartame；
5.25 parts of hydroxyapatite；
4.5 parts of micron order magnesium powder；
0.5 part of sodium fluoride；
0.25 part of calcirm-fluoride；
2.25 parts of borax；
2.25 parts of Yunnan Baiyao extract；
11.9 parts of deionized water.
Example IV
A kind of antibacterial toothpaste of hydroxyl apatite includes following component by its parts by weight：
22.5 parts of precipitated calcium carbonate；
10 parts of precipitated silica；
5 parts of Carbon Dioxide hydrogen calcium；
Two 12.5 parts of aqueous carbonate hydrogen calcium；
12 parts of glycerine；
13 parts of butanediol；
1.2 parts of dodecyl sodium sulfate；
0.8 part of acrylic acid polymer；
0.5 part of carragheen；
0.1 part of STEVIA REBAUDIANA；
0.3 part of xylitol；
0.1 part of Aspartame；
4 parts of hydroxyapatite；
2.5 parts of micron order magnesium powder；
0.25 part of potassium fluoride；
0.25 part of magnesium fluoride；
1.5 parts of borax；
1.5 parts of Yunnan Baiyao extract；
12 parts of deionized water.
Embodiment five
A kind of antibacterial toothpaste of hydroxyl apatite includes following component by its parts by weight：
30 parts of precipitated calcium carbonate；
12 parts of precipitated silica；
3 parts of Carbon Dioxide hydrogen calcium；
Two 15 parts of aqueous carbonate hydrogen calcium；
5 parts of propylene glycol；
15 parts of glycerine；
1.2 parts of dodecyl sodium sulfate；
0.8 part of acrylic acid polymer；
0.05 part of hydroxyethyl cellulose；
0.05 part of carragheen；
0.3 part of STEVIA REBAUDIANA；
0.2 part of xylitol；
0.1 part of peppermint oil；
1.7 parts of hydroxyapatite；
1 part of micron order magnesium powder；
0.25 part of sodium fluoride；
0.25 part of calcirm-fluoride；
0.9 part of borax；
0.9 part of Yunnan Baiyao extract；
12.3 parts of deionized water.
Embodiment six
A kind of antibacterial toothpaste of hydroxyl apatite includes following component by its parts by weight：
19.25 parts of precipitated calcium carbonate；
5.25 parts of precipitated silica；
3.5 parts of Carbon Dioxide hydrogen calcium；
Two 7 parts of aqueous carbonate hydrogen calcium；
13 parts of propylene glycol；
20 parts of butanediol；
0.3 part of dodecyl sodium sulfate；
0.2 part of acrylic acid polymer；
2 parts of xanthans；
1 part of carragheen；
0.2 part of xylitol；
0.2 part of peppermint oil；
0.2 part of Aspartame；
6.981 parts of hydroxyapatite；
2.685 parts of micron order magnesium powder；
0.79 part of sodium fluoride；
0.5 part of potassium fluoride；
0.5 part of magnesium fluoride；
3.222 parts of borax；
3.222 parts of Yunnan Baiyao extract；
10 parts of deionized water.
Embodiment seven
A kind of antibacterial toothpaste of hydroxyl apatite includes following component by its parts by weight：
21.9 parts of precipitated calcium carbonate；
3.65 parts of precipitated silica；
5.475 parts of Carbon Dioxide hydrogen calcium；
Two 5.475 parts of aqueous carbonate hydrogen calcium；
5 parts of propylene glycol；
10 parts of glycerine；
10 parts of butanediol；
0.6 part of dodecyl sodium sulfate；
0.4 part of acrylic acid polymer；
1 part of colloidality aluminium-magnesium silicate；
1 part of carragheen；
0.15 part of STEVIA REBAUDIANA；
0.15 part of xylitol；
0.2 part of peppermint oil；
5 parts of hydroxyapatite；
4 parts of micron order magnesium powder；
3 parts of sodium fluoride；
4 parts of borax；
4 parts of Yunnan Baiyao extract；
15 parts of deionized water.
Embodiment eight
A kind of antibacterial toothpaste of hydroxyl apatite includes following component by its parts by weight：
26.78 parts of precipitated calcium carbonate；
4.12 parts of precipitated silica；
4.12 parts of Carbon Dioxide hydrogen calcium；
Two 6.18 parts of aqueous carbonate hydrogen calcium；
10 parts of propylene glycol；
10 parts of glycerine；
1.2 parts of dodecyl sodium sulfate；
0.8 part of acrylic acid polymer；
0.5 part of xanthans；
1 part of hydroxyethyl cellulose；
0.2 part of xylitol；
0.1 part of peppermint oil；
4.5 parts of hydroxyapatite；
2.25 parts of micron order magnesium powder；
2.25 parts of potassium fluoride；
3 parts of borax；
3 parts of Yunnan Baiyao extract；
20 parts of deionized water.
Embodiment nine
A kind of antibacterial toothpaste of hydroxyl apatite includes following component by its parts by weight：
28.35 parts of precipitated calcium carbonate；
6.075 parts of precipitated silica；
2.025 parts of Carbon Dioxide hydrogen calcium；
Two 4.05 parts of aqueous carbonate hydrogen calcium；
10 parts of propylene glycol；
10 parts of butanediol；
1.2 parts of dodecyl sodium sulfate；
0.8 part of acrylic acid polymer；
1 part of colloidality aluminium-magnesium silicate；
1 part of hydroxyethyl cellulose；
0.2 part of STEVIA REBAUDIANA；
0.15 part of peppermint oil；
0.15 part of Aspartame；
3 parts of hydroxyapatite；
2.4 parts of micron order magnesium powder；
0.8 part of calcirm-fluoride；
1.6 parts of borax；
2.2 parts of Yunnan Baiyao extract；
25 parts of deionized water.
Embodiment ten
A kind of antibacterial toothpaste of hydroxyl apatite includes following component by its parts by weight：
Precipitated calcium carbonate 22
2 parts of precipitated silica；
8 parts of Carbon Dioxide hydrogen calcium；
Two 8 parts of aqueous carbonate hydrogen calcium；
10 parts of glycerine；
10 parts of butanediol；
1.2 parts of dodecyl sodium sulfate；
0.8 part of acrylic acid polymer；
1 part of colloidality aluminium-magnesium silicate；
0.5 part of xanthans；
1 part of hydroxyethyl cellulose；
0.1 part of carragheen；
0.2 part of peppermint oil；
0.2 part of Aspartame；
1.25 parts of hydroxyapatite；
0.9 part of micron order magnesium powder；
0.65 part of magnesium fluoride；
0.95 part of borax；
1.25 parts of Yunnan Baiyao extract；
30 parts of deionized water.
The technical principle of the present invention is described above in association with specific embodiment.These descriptions are intended merely to explain the present invention's
Principle, and it cannot be construed to limiting the scope of the invention in any way.Based on the explanation herein, the technology of this field
Personnel would not require any inventive effort the other specific implementation modes that can associate the present invention, these modes are fallen within
Within protection scope of the present invention.
Claims (7)
1. a kind of antibacterial toothpaste of hydroxyl apatite, including abrasive, moisturizer, surfactant, thickener, flavoring agent,
Dental Erosion nursing compositions and deionized water are it is characterized in that each component is as follows by mass fraction proportion：
35~60 parts of abrasive；
20~33 parts of moisturizer；
0.5~2 part of surfactant；
0.1~3 part of thickener；
0.1~0.6 part of flavoring agent；
5~15 parts of Dental Erosion nursing compositions；
10~30 parts of deionized water.
2. a kind of antibacterial toothpaste of hydroxyl apatite according to claim 1, it is characterised in that the abrasive uses
The mixture of precipitated calcium carbonate, precipitated silica, Carbon Dioxide hydrogen calcium and two aqueous carbonate hydrogen calcium, each component are heavy such as in mass ratio
Under：
30~70 parts of precipitated calcium carbonate；
5~25 parts of precipitated silica；
5~20 parts of Carbon Dioxide hydrogen calcium；
Two 10~25 parts of aqueous carbonate hydrogen calcium.
3. a kind of antibacterial toothpaste of hydroxyl apatite according to claim 1, it is characterised in that the moisturizer is sweet
The composition of one or more of oil, propylene glycol, butanediol.
4. a kind of antibacterial toothpaste of hydroxyl apatite according to claim 1, it is characterised in that the surfactant
For dodecyl sodium sulfate（SDS）With the mixture of acrylic acid polymer, the preferred dodecyl sodium sulfate（SDS）With
The mass ratio of acrylic acid polymer is 3：2.
5. a kind of antibacterial toothpaste of hydroxyl apatite according to claim 1, it is characterised in that the thickener is hydroxyl
The mixture of one or more of ethyl cellulose, xanthans, carragheen, colloidality aluminium-magnesium silicate, preferred thickener use
Colloidality aluminium-magnesium silicate.
6. a kind of antibacterial toothpaste of hydroxyl apatite according to claim 1, it is characterised in that the Dental Erosion shield
The mixture that reason ingredient is made of hydroxyapatite, micron order magnesium powder, metal fluoride, borax, Yunnan Baiyao extract, institute
It is as follows to state hydroxyapatite, micron order magnesium powder, metal fluoride, borax, the weight ratio of Yunnan Baiyao extract：
25 parts~40 parts of hydroxyapatite；
15 parts~40 parts of micron order magnesium powder；
5 parts~15 parts of metal fluoride；
15~20 parts of borax；
10~25 parts of Yunnan Baiyao extract；The size of the preferred micron order magnesium powder is between 75-150 microns.
7. being included the following steps according to a kind of preparation method of the antibacterial toothpaste of hydroxyl apatite described in claim 1 to 6：
（1）The nano hydroxyapatite powder of selected mass fraction and pure magnesium powder are uniformly mixed with powder batch mixer；
（2）By mixed pressed by powder at sintering precast body under the conditions of the uniaxial pressure of 150Mpa-300Mpa；
（3）The step（2）Precast body be put into crucible, it is spare after high steam carries out disinfection；
（4）The step（3）The crucible equipped with precast body be put into high temperature sintering furnace, burnt between 1090-1250 degrees Celsius
Knot 2-4 hours；
（5）The step（4）Sintered sintered body carries out disinfection with high pressure steam, drying；
（6）The step（5）Obtained product is uniformly mixed with abrasive, metal fluoride, borax, Yunnan Baiyao extract；
（7）A certain amount of moisturizer, surfactant, thickener, flavoring agent, deionized water are uniformly mixed, solid matter is made
Fully dissolving；
（8）By step（1）With step（2）Products therefrom mixes, and stirs；
（9）By step（3）Products therefrom sealing, high-temperature sterilization, cooling, encapsulation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810318714.5A CN108272646A (en) | 2018-04-11 | 2018-04-11 | A kind of antibacterial toothpaste and preparation method thereof of hydroxyl apatite |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810318714.5A CN108272646A (en) | 2018-04-11 | 2018-04-11 | A kind of antibacterial toothpaste and preparation method thereof of hydroxyl apatite |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108272646A true CN108272646A (en) | 2018-07-13 |
Family
ID=62811532
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810318714.5A Pending CN108272646A (en) | 2018-04-11 | 2018-04-11 | A kind of antibacterial toothpaste and preparation method thereof of hydroxyl apatite |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108272646A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111773166A (en) * | 2020-08-10 | 2020-10-16 | 浙江埃普瑞纳米材料有限公司 | Hydroxyapatite type toothpaste |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103495174A (en) * | 2013-09-13 | 2014-01-08 | 中国人民解放军第四军医大学 | Multi-effect external preparation used for treating superficial skin injury and application thereof |
| CN106074195A (en) * | 2016-07-06 | 2016-11-09 | 杭州皎洁口腔保健用品有限公司 | A kind of toothpaste of hydroxyl apatite and calcium carbonate and preparation method thereof |
| CN107049828A (en) * | 2017-06-22 | 2017-08-18 | 缪来耿 | A kind of anti-caries toothpaste and preparation method thereof |
-
2018
- 2018-04-11 CN CN201810318714.5A patent/CN108272646A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103495174A (en) * | 2013-09-13 | 2014-01-08 | 中国人民解放军第四军医大学 | Multi-effect external preparation used for treating superficial skin injury and application thereof |
| CN106074195A (en) * | 2016-07-06 | 2016-11-09 | 杭州皎洁口腔保健用品有限公司 | A kind of toothpaste of hydroxyl apatite and calcium carbonate and preparation method thereof |
| CN107049828A (en) * | 2017-06-22 | 2017-08-18 | 缪来耿 | A kind of anti-caries toothpaste and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111773166A (en) * | 2020-08-10 | 2020-10-16 | 浙江埃普瑞纳米材料有限公司 | Hydroxyapatite type toothpaste |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5690567B2 (en) | Hydrogel particles | |
| JP4702561B2 (en) | Dentifrice composition | |
| JP5444854B2 (en) | Dentifrice composition | |
| WO2013117913A2 (en) | Multicomponent oral care composition | |
| BR112012030590B1 (en) | Non-aqueous Composition for Oral Care and Process for Preparing a Non-aqueous Composition for Oral Care | |
| EP3723699A1 (en) | Novel composition | |
| CN108272646A (en) | A kind of antibacterial toothpaste and preparation method thereof of hydroxyl apatite | |
| JP2011195552A (en) | Composition for oral cavity | |
| BR112014002498B1 (en) | NON-WATERY ORAL TREATMENT COMPOSITION | |
| WO2015019601A1 (en) | Dentinal tubule sealing material | |
| JP5444855B2 (en) | Dentifrice composition | |
| EP2833859B1 (en) | Non-aqueous oral care composition | |
| JP2566676B2 (en) | Dental composition | |
| JP2010111647A (en) | Dentifrice composition | |
| EP3522855B1 (en) | Process for manufacture of non-aqueous oral care compositions | |
| JP2609909B2 (en) | Medical or dental curable composition | |
| Gul et al. | Comparative fluoride release and antimicrobial analysis of commercial and experimental bioactive glass/nano-oxide-based dentifrices | |
| JP2016069291A (en) | Tooth bleaching composition | |
| JPH02311413A (en) | Composition for tooth paste | |
| CN115429709A (en) | Preparation method of toothpaste containing bioactive glass | |
| JP6555722B2 (en) | Tooth surface restoration material | |
| WO2024046751A1 (en) | Process for the manufacture of a non-aqueous composition | |
| WO2022264811A1 (en) | Dentifrice composition | |
| JP5720416B2 (en) | Gel oral composition and method for producing the same | |
| JPH03200712A (en) | Composition for oral cavity application |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20180713 |
|
| WD01 | Invention patent application deemed withdrawn after publication |