CN108272084A - It is a kind of prevent thermoplegia composition and its application - Google Patents

It is a kind of prevent thermoplegia composition and its application Download PDF

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Publication number
CN108272084A
CN108272084A CN201810025494.7A CN201810025494A CN108272084A CN 108272084 A CN108272084 A CN 108272084A CN 201810025494 A CN201810025494 A CN 201810025494A CN 108272084 A CN108272084 A CN 108272084A
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parts
composition
thermoplegia
composition according
glutamine
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杨峰
李新方
马志强
王丹
胡鹏伟
陈敏
王骐榕
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Second Military Medical University SMMU
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Second Military Medical University SMMU
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/175—Amino acids
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Mycology (AREA)
  • Food Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Nutrition Science (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

The present invention relates to a kind of compositions preventing thermoplegia and its application, its active constituent of the composition to be made of the raw material of following weight：35~45 parts of L glutamine, 25~35 parts of glucose, 15~25 parts of sodium citrate, 4~6 parts of sodium chloride, 1~3 part of potassium chloride.Through mouse thermoplegia prophylactic tria, biochemical indicator detection and pathological study, it was demonstrated that the present composition can compensate for nutrition and electrolyte metabolism, and induction heat shock protein generates, and has good prevention thermoplegia and heat stress damage effect.The composition can be made into food, health products or the drug for preventing thermoplegia effect, the auxiliary product etc. as staff's health under protection high temperature, high humidity particular surroundings.

Description

It is a kind of prevent thermoplegia composition and its application
Technical field
The present invention relates to field of food, specifically, being related to a kind of composition preventing thermoplegia, and its are eaten preparing Application in product, health products or drug.
Background technology
Thermoplegia is severe heat stroke, is a kind of fatal disease.As under high temperature, high humidity particular surroundings operation it is multiple Disease has the characteristics that incidence is high, the course of disease is hurried, invalid case fatality rate is high, seriously jeopardizes and work under high temperature, high humidity particular surroundings The health of personnel, it was reported that its death rate is up to 50% or more.
Domestic at present is that chlorpromazine injection calmness combines various Physical temperature-lowering means to make to the conventional treatments of thermoplegia Patient temperature rapid decrease, block internal inflammation waterfall reaction and correct blood coagulation-anticoagulation Balance disorders etc..It adopts in recent years Continuous blood purification technology also improves the survival rate of thermoplegia patient to a certain degree.But because the disease is often along with cross Line myolysis, endotoxin are released into the symptoms such as blood and organ failure, cause the irreversible damage of whole body popularity, report For the death rate still in 20%-80% or so, prognosis is poor, and current treatment means are still difficult to effectively improve treatment rate.And it is current Still lack its specific aim prophylactic agent, therefore, the research prevented thermoplegia is just particularly important.
Studies have shown that there is some amino acid certain thermoplegia and heat stress to damage prevention effect.Glutamine is in body The interior generation that can induce heat shock protein, and heat shock protein can protect enterocyte, delay or avoid in enteron aisle Toxin enters circulatory system threat to life, and the albumen inactivated in vivo is made to fold again, to activity recovery.There is document in cell Glutamine is demonstrated in culture model can increase HSP70 expression in cell, take precautions against cell by heat injury.Also document report Road intravenous glutamine can induce in the rat heart, lung and colonic tissue generates HSP70, prevents rat by endogenous toxic material The infringement of element.Patent document CN103623390A, publication date 2014.03.12 are provided a kind of containing pharmaceutically acceptable The therapeutic agent of single dose glutamine in carrier, for treat and prevent cell metabolism damage, prevent heart cell damage and Increase the therapeutic combination of heat shock protein expression.Periodical《The contemporary medicine collection of essay》, paper that the 4th periodical of volume 14 in 2016 goes out " combination glutamine and vitamin C prevent heatstroke and the effect analysis of endotoxemia ", has inquired into and glutamine is used in combination Prevent the effect of heatstroke and endotoxemia with vitamin C.Method：By during in August, 2015 in September, -2015 in hot conditions Under 120 soldiers that have military drill as research object, be randomly divided into joint group and conventional group, every group has 60 People.During this two groups of people have military drill, prophylactic treatment is carried out using oral rehydration salts for conventional group people, it is basic herein On, add for joint group people and carries out prophylactic treatment with glutamine and vitamin C.After military training, compare two groups of people into The preventative-therapeutic effect of row, the incidence of the incidence of heatstroke and endotoxemia.As a result：Joint group people carries out preventative control The total effective rate for the treatment of is apparently higher than conventional group people, and the two has conspicuousness (P compared to difference<0.05).The hair of joint group people's heatstroke The incidence of raw rate and endotoxemia is significantly lower than conventional group people, and the two has conspicuousness (P compared to difference<0.05).Knot By：Glutamine is used in combination and vitamin C prevents the definite effect of heatstroke and endotoxemia.This drug combination method can be made To prevent the preferred method of heatstroke and endotoxemia.
In addition, periodical《Chinese Clinical doctor's magazine》, paper " cold glucose saline that the 7th periodical of volume 29 in 2001 goes out And 26 analyses of chlorpromazine combination rescue severe heat stroke ", it was recently reported that severe heat stroke is rescued using cold glucose saline and chlorpromazine Patient obtains remarkable result.Patent document CN1449691A, publication date 2003.10.22 are disclosed a kind of with anti-heatstroke work( The effervescent beverage(s) of energy, by citric acid, sodium citrate, NaHCO3, Aspartame, essence, potassium chloride, calcium chloride, magnesium sulfate, sulfuric acid Iron, zinc sulfate, vitamin B1, vitamin B2, vitamin B6, VitAVitE, vitamin C, niacin according to a certain percentage It is made, has the function of anti-heatstroke.
To sum up, report big quantity of material in the prior art has certain effect in treating or preventing thermoplegia.However, being Fully prevent the generation of thermoplegia, it is necessary to provide a kind of significantly more product of effect.
Invention content
The purpose of the present invention is being directed to deficiency in the prior art, a kind of composition preventing thermoplegia is provided and its is answered With.
Present invention firstly provides a kind of for preventing the composition of thermoplegia, its active constituent of the composition by with The raw material of lower weight forms：35~45 parts of L-Glutamine, 25~35 parts of glucose, 15~25 parts of sodium citrate, chlorine Change 4~6 parts of sodium, 1~3 part of potassium chloride.
More preferably, the active constituent is made of the raw material of following weight：40 parts of L-Glutamine, glucose 30 parts, 23 parts of sodium citrate, 5 parts of sodium chloride, 2 parts of potassium chloride.
More preferably, the composition also includes the auxiliary material for being used to prepare food, health products or drug.
More specifically, the auxiliary material can be selected from flavoring agent, colorant, cosolvent, emulsifier, excipient, filler, glue Mixture, wetting agent, disintegrant and sorbefacient, but it is not limited only to this.
As the specific embodiment of the present invention, the flavoring agent is selected from xylitol and peppermint oil.
As the specific embodiment of the present invention, the cosolvent is selected from beta-cyclodextrin and maltodextrin.
As the specific embodiment of the present invention, the emulsifier is selected from acetylation mono-fatty acid glyceride and acetyl Change diglycerine fatty acid ester.
As the specific embodiment of the present invention, the excipient is selected from magnesium stearate and microcrystalline cellulose.
More preferably, the composition can be further made powder, capsule, granule, tablet, pill, oral solution, Electuary, effervescent tablet, beverage or food ingredient packet, but it is not limited only to this.
The present invention also provides the composition answering in preparing the food, health products or drug that prevent thermoplegia With.
Herein, the flavoring agent, colorant, cosolvent, emulsifier, excipient, filler, adhesive, wetting agent, Disintegrant and sorbefacient are to prepare customary adjuvant used in food, health products or drug, for people in the art For member, also know that the auxiliary material that can be used for the present composition is not limited only to the above-mentioned type.
The flavoring agent can be acid, sweetener, such as phosphoric acid, lactic acid, tartaric acid, metatartaric acid, malic acid, Fumaric acid, acetic acid, succinic acid, xylitol, stevioside, honey element, L-aspartyl-L-phenylalanine methylester, peppermint oil etc..It is described Colorant can be plant colorant, animal colorant or microorganism colorant, such as beet red, turmeric, chlorophyll, lac Red, alkermes, red yeast rice colouring agent etc..The cosolvent such as beta-cyclodextrin, maltodextrin, tween, ethyl alcohol, spans, Lauryl sodium sulfate, propylene glycol, polyethylene glycol, glycerine etc..The emulsifier such as acetylation mono-fatty acid glyceride, second Acylated diglycerine fatty acid ester, sucrose ester, sorbose alcohol ester, soybean lecithin, lauric monoglyceride, methyl glycol fatty acid ester, Stearyl lactate, diacetyl tartarate, glycerin monostearate, modified soy bean lipoid etc..The excipient is such as stearic The polyethylene glycol etc. of sour magnesium, microcrystalline cellulose, lactose, toffee, high molecular weight.The filler such as starch, mannitol, silicon Acid, dextrin, calcium monohydrogen phosphate, cellulose etc..The adhesive such as carboxymethyl cellulose, alginate, gelatin, polyethylene pyrrole Pyrrolidone, Arabic gum, starch slurry, hydroxypropul starch, modified starch, pregelatinized starch, dextrin, microcrystalline cellulose, polyethylene Pyrrolidones rubber cement, gelatine size.Described wetting agent glycerine etc..The disintegrant such as agar, calcium carbonate, potato Starch, tapioca, alginic acid, hydroxypropul starch, modified starch, sodium carboxymethyl starch, microcrystalline cellulose, guar gum, Siberian cocklebur Glue, xanthans etc..The sorbefacient such as quaternary ammonium compound, effervescent agent, cyclodextrin, vitamin D and its derivative, Hu Green pepper alkali etc..
Powder, capsule, granule, tablet, pill, oral solution, electuary, effervescent tablet, beverage or the food ingredient Packet be all food, the conventionally form of health products or drug regular dosage form also know this hair to those skilled in the art Bright composition can be prepared into arbitrary acceptable form according to method in the prior art.
The composition of the present invention can be used for preventing thermoplegia, and including but not limited to heatstroke, severe heat stroke, heat stress are damaged The prevention or treatment of wound.
The invention has the advantages that：
1, formula is reasonable：The present composition includes the raw material that heat shock protein can be induced to generate, and also includes that can mend Repay the raw material of nutrition and electrolyte metabolism.The selection of raw material combines the abundant research experience of inventor, and each material combination uses, It is mutually coordinated, achieve unexpected technique effect；
2, the present composition can induce heat shock protein to generate, and prevent gut barrier, enhancing intestines that work(is immunized Can, the transposition of bacterium is reduced, intestinal endotoxemia is prevented；
3, the present composition can supplement the nutrients, and supplement water salt, improve cycle decompensation；
4, present composition raw material is natural materials, is free of chemical synthesis substance, and safety is without side-effects；
5, the food of diversified forms, health food can be made in the present composition, such as capsule, tablet, electuary, effervesce Piece, beverage, food ingredient packet etc., suitable for being taken in various occasions, easy to carry and preservation.
To sum up, the present composition can be used as the auxiliary product of staff's health under protection high temperature, high humidity particular surroundings Deng.
Description of the drawings
Attached drawing 1 is thermoplegia model mice survival rate curve.
Specific implementation mode
It in order to make the object, technical scheme and advantages of the embodiment of the invention clearer, below will be in the embodiment of the present invention Technical solution be clearly and completely described, it is clear that described embodiments are some of the embodiments of the present invention, rather than Whole embodiments.It should be noted that unrelated to the invention, the common skill in this field is omitted for purposes of clarity, in explanation The expression and description of component and processing known to art personnel.Based on the embodiments of the present invention, those of ordinary skill in the art exist The every other embodiment obtained under the premise of not making the creative labor, shall fall within the protection scope of the present invention.
1 present invention of embodiment prevents the powder (one) of thermoplegia composition
1. weighing raw material according to following weight：42 parts of L-Glutamine, 30 parts of glucose, 21 parts of sodium citrate, 4.5 parts of sodium chloride, 3 parts of potassium chloride.
2. the preparation of powder
Raw material by said ratio mixing after it is finely ground, cross No. 7 sieve, subpackage to get.
2 present invention of embodiment prevents the powder (two) of thermoplegia composition
1. weighing raw material according to following weight：35 parts of L-Glutamine, 25 parts of glucose, 15 parts of sodium citrate, 5 parts of sodium chloride, 2.5 parts of potassium chloride.
2. the preparation of powder
Raw material by said ratio mixing after it is finely ground, cross No. 7 sieve, subpackage to get.
3 present invention of embodiment prevents the powder (three) of thermoplegia composition
1. weighing raw material according to following weight：35 parts of L-Glutamine, 35 parts of glucose, 15 parts of sodium citrate, 6 parts of sodium chloride, 1 part of potassium chloride.
2. the preparation of powder
Raw material by said ratio mixing after it is finely ground, cross No. 7 sieve, subpackage to get.
4 present invention of embodiment prevents the powder (four) of thermoplegia composition
1. weighing raw material according to following weight：45 parts of L-Glutamine, 25 parts of glucose, 25 parts of sodium citrate, 4 parts of sodium chloride, 3 parts of potassium chloride.
2. the preparation of powder
Raw material by said ratio mixing after it is finely ground, cross No. 7 sieve, subpackage to get.
5 present invention of embodiment prevents the powder (five) of thermoplegia composition
1. weighing raw material according to following weight：45 parts of L-Glutamine, 35 parts of glucose, 15 parts of sodium citrate, 4 parts of sodium chloride, 3 parts of potassium chloride.
2. the preparation of powder
Raw material by said ratio mixing after it is finely ground, cross No. 7 sieve, subpackage to get.
6 present invention of embodiment prevents the powder (six) of thermoplegia composition
1. weighing raw material according to following weight：35 parts of L-Glutamine, 25 parts of glucose, 25 parts of sodium citrate, 4 parts of sodium chloride, 1 part of potassium chloride.
2. the preparation of powder
Raw material by said ratio mixing after it is finely ground, cross No. 7 sieve, subpackage to get.
7 present invention of embodiment prevents the powder (seven) of thermoplegia composition
1. weighing raw material according to following weight：40 parts of L-Glutamine, 30 parts of glucose, 23 parts of sodium citrate, 5 parts of sodium chloride, 2 parts of potassium chloride.
2. the preparation of powder
Raw material by said ratio mixing after it is finely ground, cross No. 7 sieve, subpackage to get.
8 present invention of embodiment prevents the granule of thermoplegia composition
1. weighing raw material according to following weight：42 parts of L-Glutamine, 30 parts of glucose, 21 parts of sodium citrate, 4.5 parts of sodium chloride, 3 parts of potassium chloride, hydroxypropyl methyl cellulose 5g.
2. the preparation of granule
After raw material is by said ratio mixing, with ethyl alcohol softwood, the sieve pelleting of 16 mesh, dry, whole grain, packing to get.
9 present invention of embodiment prevents the beverage of thermoplegia composition
1. weighing raw material according to following weight：42 parts of L-Glutamine, 30 parts of glucose, 21 parts of sodium citrate, 4.5 parts of sodium chloride, 3 parts of potassium chloride.
2. the preparation of beverage
After raw material is by said ratio mixing, add acetylation mono-fatty acid glyceride and acetylation diglycerine fatty acid ester and pure Water purification mixes well, disinfection, packing to get.
10 present invention of embodiment prevents the tablet of thermoplegia composition
1. weighing raw material according to following weight：42 parts of L-Glutamine, 30 parts of glucose, 21 parts of sodium citrate, 4.5 parts of sodium chloride, 3 parts of potassium chloride.
2. the preparation of tablet
After raw material is by said ratio mixing, add 5 parts of xylitols, 2 portions of peppermint oils, it is dry with ethyl alcohol softwood, it is tabletted Agent to get.
11 present invention of embodiment prevents the oral solution of thermoplegia composition
1. weighing raw material according to following weight：42 parts of L-Glutamine, 30 parts of glucose, 21 parts of sodium citrate, 4.5 parts of sodium chloride, 3 parts of potassium chloride.
2. the preparation of oral solution
After raw material is by said ratio mixing, 5 parts of beta-cyclodextrins, 5 portions of maltodextrins, appropriate distilled water is added to mix well, filled Dress to get.
The mouse thermoplegia prophylactic tria of 12 present composition of embodiment
1. thermoplegia Establishment of mouse model
Select male mouse of kunming (20 ± 2) g in the case where standardize rearing conditions (12 hours illumination/dark, tap water, oneself By searching for food) raising.When experiment, mouse is placed in heat chamber (being provided by environmental sanitation teaching and research room of The 2nd Army Medical College), temperature is： (40 ± 1) DEG C, humidity are：Under (60 ± 5) %, 120min to 150min is generally the time required to modeling, with anus temperature (41 ± 1) DEG C Judge whether modeling succeeds.
2. experimental animal is grouped and experimental observation record
18 male mouse of kunming (20 ± 2) g are randomly divided into 3 groups：Normal group (A groups), Heat-temperature stress group (B Group), present composition prevention group (C groups).It stress preceding about 1h gavages.B groups give distilled water 0.4ml/ only, and C groups give this hair The composition of bright embodiment 7 0.4ml/, dosage 4000mg/kg.It is heat-treated by above-mentioned modeling method, when recording mouse survival Between, the results are shown in Table 1, draws survival rate curve, as shown in Figure 1.
1 thermoplegia model mice amount of survival of table and survival rate
3. sample is collected and detection
Each group takes 1 mouse after thermoplegia occurs, and blood, 3000rpm is taken to centrifuge 15min, take supernatant, survey following internal organs after 2h Functional parameter：The lactic dehydrogenase (LDH) and creatine kinase (CK)-CRO for representing cardiac function, the millet straw for representing liver function turn Ammonia enzyme (ALT), aspartate amino transferase (AST), alkaline phosphatase (ALP), total bilirubin (TBIL) and blood glucose (Glu), the urea (UREA) and creatinine (CR) of renal function are represented, the results are shown in Table 2.Take thermoplegia that may damage dirty Device：Heart, lung, liver, spleen, kidney and small intestine are fixed in tissue fixative solution immediately after materials, and paraffin is dehydrated, embeds, cuts After piece, HE dyeing carries out the pathological study of internal organs.
2 thermoplegia model mice biochemical indicator of table
Note：Group difference significance analysis is carried out to data using Excel2013.*, compared with A groups, P<0.05；#, B group Compare with C groups, P<0.05.
Test result shows that the present invention prevents thermoplegia composition and has preferable preventive effect, mouse to exist thermoplegia There are higher survival rate, biochemical indicator to be intended to normal value under hot environment, organs and tissues are without apparent damage.The pre- solar heat protection of the present invention Penetrating disease composition can be as staff under specific aim prevention food, health products or medicament protection high temperature, high humidity particular surroundings Health.
13 composite formula screening test of embodiment
Enlarged sample amount, screens composite formula, is provided with many experiments group, wherein including following experimental group (being shown in Table 3).1 administered volume of experimental group is 0.4ml/, remaining each group administered volume 0.4ml/, dosage 4000mg/kg.
3 composite formula screening test of table is grouped
It is tested according to the method for embodiment 12, records each time point mouse survival situation, each group after thermoplegia occurs Take 3 mouse detection mouse biochemical indicators.Each time point survival rate statistical result of mouse is shown in Table 4.Mouse biochemical indicator statistics knot Fruit is shown in Table 5.For mouse biochemical indicator, group difference significance analysis is carried out to data using Excel2013, as a result experimental group For 2 indices compared with the corresponding indexs of experimental group 3-5, difference all has statistical significance (P<0.05).
4 thermoplegia model mice survival rate of table
5 thermoplegia model mice biochemical indicator of table
Note：Data are average value in table.
Test result shows that assembling for present invention prevention thermoplegia composition active constituent is appropriate, in each active constituent Under synergistic effect, more significant prevention effect can be played compared to other each groups.
The above is only a preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art Member, under the premise of not departing from the method for the present invention, can also make several improvement and supplement, these are improved and supplement also should be regarded as Protection scope of the present invention.

Claims (10)

1. a kind of composition for preventing thermoplegia, which is characterized in that its active constituent of the composition is by following weight The raw material composition of part proportioning：35~45 parts of L-Glutamine, 25~35 parts of glucose, 15~25 parts of sodium citrate, sodium chloride 4~ 6 parts, 1~3 part of potassium chloride.
2. composition according to claim 1, which is characterized in that the active constituent by following weight original Material composition：40 parts of L-Glutamine, 30 parts of glucose, 23 parts of sodium citrate, 5 parts of sodium chloride, 2 parts of potassium chloride.
3. composition according to claim 1, which is characterized in that the composition also includes to be used to prepare food, protect The auxiliary material of strong product or drug.
4. composition according to claim 3, which is characterized in that the auxiliary material is selected from flavoring agent, colorant, hydrotropy Agent, emulsifier, excipient, filler, adhesive, wetting agent, disintegrant and sorbefacient.
5. composition according to claim 4, which is characterized in that the flavoring agent is selected from xylitol and peppermint oil.
6. composition according to claim 4, which is characterized in that the cosolvent is selected from beta-cyclodextrin and malt is pasted Essence.
7. composition according to claim 4, which is characterized in that the emulsifier is selected from acetylation list glycerine fatty acid Ester and acetylation diglycerine fatty acid ester.
8. composition according to claim 4, which is characterized in that the excipient is selected from magnesium stearate and microcrystalline cellulose Element.
9. composition according to claim 1, which is characterized in that powder, capsule is further made in the composition Agent, granule, tablet, pill, oral solution, electuary, effervescent tablet, beverage or food ingredient packet.
10. application of the composition as claimed in claim 1 or 2 in preparing the food, health products or drug that prevent thermoplegia.
CN201810025494.7A 2018-01-11 2018-01-11 It is a kind of prevent thermoplegia composition and its application Pending CN108272084A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112933151A (en) * 2021-01-29 2021-06-11 中国人民解放军空军特色医学中心 Liquid supplementing salt composition for preventing labor type heatstroke

Citations (3)

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Application publication date: 20180713